ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	5.11185198
2	epithelial cilium movement (GO:0003351)	4.45377684
3	DNA double-strand break processing (GO:0000729)	4.23100204
4	behavioral response to nicotine (GO:0035095)	4.08639583
5	cilium movement (GO:0003341)	4.04491332
6	regulation of hippo signaling (GO:0035330)	3.81930227
7	somite development (GO:0061053)	3.74859240
8	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	3.68338762
9	negative regulation of translation, ncRNA-mediated (GO:0040033)	3.68338762
10	regulation of translation, ncRNA-mediated (GO:0045974)	3.68338762
11	cilium or flagellum-dependent cell motility (GO:0001539)	3.56362959
12	indole-containing compound catabolic process (GO:0042436)	3.56238750
13	indolalkylamine catabolic process (GO:0046218)	3.56238750
14	tryptophan catabolic process (GO:0006569)	3.56238750
15	regulation of non-canonical Wnt signaling pathway (GO:2000050)	3.53838293
16	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.51156058
17	axoneme assembly (GO:0035082)	3.48612084
18	centriole replication (GO:0007099)	3.44858714
19	regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)	3.36128069
20	regulation of posttranscriptional gene silencing (GO:0060147)	3.32736598
21	regulation of gene silencing by miRNA (GO:0060964)	3.32736598
22	regulation of gene silencing by RNA (GO:0060966)	3.32736598
23	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.23448416
24	fucose catabolic process (GO:0019317)	3.17736708
25	L-fucose metabolic process (GO:0042354)	3.17736708
26	L-fucose catabolic process (GO:0042355)	3.17736708
27	protein polyglutamylation (GO:0018095)	3.17540317
28	neural tube formation (GO:0001841)	3.17399525
29	kidney morphogenesis (GO:0060993)	3.15065519
30	limb bud formation (GO:0060174)	3.13549928
31	presynaptic membrane assembly (GO:0097105)	3.10057381
32	cilium organization (GO:0044782)	3.09675079
33	indolalkylamine metabolic process (GO:0006586)	3.08551506
34	cilium assembly (GO:0042384)	3.04346725
35	negative regulation of neurotransmitter transport (GO:0051589)	2.99869539
36	axonemal dynein complex assembly (GO:0070286)	2.99622005
37	lateral sprouting from an epithelium (GO:0060601)	2.98174218
38	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.97817786
39	postsynaptic membrane organization (GO:0001941)	2.96839245
40	cilium morphogenesis (GO:0060271)	2.94560090
41	regulation of cilium movement (GO:0003352)	2.94465995
42	negative regulation of astrocyte differentiation (GO:0048712)	2.94328084
43	tryptophan metabolic process (GO:0006568)	2.90102265
44	replication fork processing (GO:0031297)	2.89240190
45	protein localization to cilium (GO:0061512)	2.88499565
46	photoreceptor cell maintenance (GO:0045494)	2.88014792
47	protein K11-linked deubiquitination (GO:0035871)	2.86540595
48	intraciliary transport (GO:0042073)	2.86113507
49	response to pheromone (GO:0019236)	2.85834316
50	sulfation (GO:0051923)	2.85325520
51	recombinational repair (GO:0000725)	2.83693915
52	double-strand break repair via homologous recombination (GO:0000724)	2.83312108
53	sperm motility (GO:0030317)	2.75218611
54	smoothened signaling pathway (GO:0007224)	2.71346133
55	establishment of protein localization to Golgi (GO:0072600)	2.69080031
56	otic vesicle formation (GO:0030916)	2.67744697
57	reflex (GO:0060004)	2.64633551
58	presynaptic membrane organization (GO:0097090)	2.62967066
59	nonmotile primary cilium assembly (GO:0035058)	2.60722985
60	behavioral response to ethanol (GO:0048149)	2.60362960
61	regulation of neurotransmitter uptake (GO:0051580)	2.59482936
62	cellular response to sterol (GO:0036315)	2.58244427
63	detection of light stimulus involved in sensory perception (GO:0050962)	2.56264236
64	detection of light stimulus involved in visual perception (GO:0050908)	2.56264236
65	cornea development in camera-type eye (GO:0061303)	2.55846191
66	spinal cord development (GO:0021510)	2.54411526
67	determination of left/right symmetry (GO:0007368)	2.53738142
68	central nervous system myelination (GO:0022010)	2.53570665
69	axon ensheathment in central nervous system (GO:0032291)	2.53570665
70	appendage development (GO:0048736)	2.52224509
71	limb development (GO:0060173)	2.52224509
72	transmission of nerve impulse (GO:0019226)	2.52017233
73	cellular component assembly involved in morphogenesis (GO:0010927)	2.51228243
74	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.50708349
75	atrial cardiac muscle cell action potential (GO:0086014)	2.46135504
76	C4-dicarboxylate transport (GO:0015740)	2.45466640
77	negative regulation of sodium ion transport (GO:0010766)	2.44625479
78	kynurenine metabolic process (GO:0070189)	2.43856248
79	regulation of alternative mRNA splicing, via spliceosome (GO:0000381)	2.43220359
80	amine catabolic process (GO:0009310)	2.42156198
81	cellular biogenic amine catabolic process (GO:0042402)	2.42156198
82	retinal rod cell development (GO:0046548)	2.42079309
83	centriole assembly (GO:0098534)	2.41162567
84	forebrain morphogenesis (GO:0048853)	2.40971926
85	pyrimidine nucleobase catabolic process (GO:0006208)	2.39262697
86	negative regulation of DNA binding (GO:0043392)	2.37896521
87	multicellular organism reproduction (GO:0032504)	2.37853617
88	spermatid development (GO:0007286)	2.37755075
89	gamma-aminobutyric acid transport (GO:0015812)	2.37615306
90	determination of bilateral symmetry (GO:0009855)	2.37474743
91	regulation of DNA endoreduplication (GO:0032875)	2.37318901
92	left/right axis specification (GO:0070986)	2.37254223
93	protein localization to Golgi apparatus (GO:0034067)	2.36492016
94	male meiosis (GO:0007140)	2.36311728
95	reciprocal DNA recombination (GO:0035825)	2.34695448
96	reciprocal meiotic recombination (GO:0007131)	2.34695448
97	regulation of meiosis I (GO:0060631)	2.34640278
98	rRNA catabolic process (GO:0016075)	2.34044373
99	specification of symmetry (GO:0009799)	2.33643595
100	hindbrain development (GO:0030902)	2.33591037

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GBX2_23144817_ChIP-Seq_PC3_Human	3.51533946
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.35282876
3	EZH2_22144423_ChIP-Seq_EOC_Human	3.30634470
4	VDR_22108803_ChIP-Seq_LS180_Human	3.06484000
5	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.00685797
6	IGF1R_20145208_ChIP-Seq_DFB_Human	2.92373883
7	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.84179869
8	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.71155887
9	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.68403660
10	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.60555876
11	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.58557348
12	FUS_26573619_Chip-Seq_HEK293_Human	2.45010595
13	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.43311255
14	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.28296621
15	TAF15_26573619_Chip-Seq_HEK293_Human	2.17674036
16	P300_19829295_ChIP-Seq_ESCs_Human	2.14278608
17	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	2.06140571
18	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.05448512
19	EWS_26573619_Chip-Seq_HEK293_Human	2.02711670
20	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.98370035
21	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.96429404
22	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.91515684
23	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.86785391
24	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.84459905
25	SMAD4_21799915_ChIP-Seq_A2780_Human	1.77671652
26	ER_23166858_ChIP-Seq_MCF-7_Human	1.75784830
27	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.71781524
28	AR_21572438_ChIP-Seq_LNCaP_Human	1.70058735
29	STAT3_23295773_ChIP-Seq_U87_Human	1.68231876
30	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.66720476
31	CBP_20019798_ChIP-Seq_JUKART_Human	1.65660828
32	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.65660828
33	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.64564108
34	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.64107708
35	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.62581828
36	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.61823934
37	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.60011772
38	AR_25329375_ChIP-Seq_VCAP_Human	1.58826831
39	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.56366617
40	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.56366617
41	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.54235187
42	TCF4_23295773_ChIP-Seq_U87_Human	1.53151014
43	BCAT_22108803_ChIP-Seq_LS180_Human	1.52595624
44	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.45373799
45	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.41908997
46	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.40720814
47	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.38594146
48	TCF4_22108803_ChIP-Seq_LS180_Human	1.36654380
49	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.36218915
50	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.33576664
51	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.33237218
52	RUNX2_22187159_ChIP-Seq_PCA_Human	1.32096637
53	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.32066170
54	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.29851922
55	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.29405716
56	RNF2_27304074_Chip-Seq_NSC_Mouse	1.28566550
57	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.26804824
58	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.26485189
59	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.25569845
60	NANOG_19829295_ChIP-Seq_ESCs_Human	1.25172180
61	SOX2_19829295_ChIP-Seq_ESCs_Human	1.25172180
62	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.22052834
63	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.20908462
64	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.20348560
65	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.20218654
66	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.19905958
67	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.19586013
68	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.19164450
69	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.17465334
70	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.15408511
71	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.14420673
72	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.13223924
73	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.12893610
74	TP53_16413492_ChIP-PET_HCT116_Human	1.09980237
75	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.09530319
76	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.08808898
77	REST_21632747_ChIP-Seq_MESCs_Mouse	1.08047653
78	AHR_22903824_ChIP-Seq_MCF-7_Human	1.07421438
79	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.06827926
80	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.06669052
81	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.05946183
82	RXR_22108803_ChIP-Seq_LS180_Human	1.05143576
83	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.05111955
84	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.04196342
85	IRF1_19129219_ChIP-ChIP_H3396_Human	1.03816756
86	P53_22387025_ChIP-Seq_ESCs_Mouse	1.03331628
87	MYC_18940864_ChIP-ChIP_HL60_Human	1.02759163
88	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.02392769
89	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.00067733
90	CDX2_22108803_ChIP-Seq_LS180_Human	0.99892832
91	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.99551720
92	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.98689553
93	FOXM1_26456572_ChIP-Seq_MCF-7_Human	0.98045866
94	NOTCH1_21737748_ChIP-Seq_TLL_Human	0.97313765
95	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	0.96185890
96	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.95119120
97	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.92460758
98	CMYC_18555785_Chip-Seq_ESCs_Mouse	0.92271345
99	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.92123361
100	P53_22127205_ChIP-Seq_FIBROBLAST_Human	0.90996973

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003136_yellow_coat_color	3.39894159
2	MP0006292_abnormal_olfactory_placode	3.16894154
3	MP0003646_muscle_fatigue	3.16796307
4	MP0000569_abnormal_digit_pigmentation	2.62508052
5	MP0008877_abnormal_DNA_methylation	2.55082332
6	MP0003195_calcinosis	2.42981403
7	MP0002102_abnormal_ear_morphology	2.41318287
8	MP0002234_abnormal_pharynx_morphology	2.11174034
9	MP0003787_abnormal_imprinting	2.08715478
10	MP0002938_white_spotting	2.06175273
11	MP0004885_abnormal_endolymph	2.05817045
12	MP0005646_abnormal_pituitary_gland	2.04471246
13	MP0005551_abnormal_eye_electrophysiolog	1.98894248
14	MP0002653_abnormal_ependyma_morphology	1.93827412
15	MP0000631_abnormal_neuroendocrine_gland	1.89548009
16	MP0002837_dystrophic_cardiac_calcinosis	1.82367886
17	MP0004043_abnormal_pH_regulation	1.80897594
18	MP0001984_abnormal_olfaction	1.79694702
19	MP0006072_abnormal_retinal_apoptosis	1.75889291
20	MP0009046_muscle_twitch	1.65605891
21	MP0003122_maternal_imprinting	1.63940126
22	MP0001486_abnormal_startle_reflex	1.58906925
23	MP0001968_abnormal_touch/_nociception	1.57631183
24	MP0001485_abnormal_pinna_reflex	1.55510414
25	MP0000372_irregular_coat_pigmentation	1.52250122
26	MP0002876_abnormal_thyroid_physiology	1.46786030
27	MP0002233_abnormal_nose_morphology	1.45352462
28	MP0009745_abnormal_behavioral_response	1.45024351
29	MP0002736_abnormal_nociception_after	1.45016053
30	MP0005253_abnormal_eye_physiology	1.43909493
31	MP0005174_abnormal_tail_pigmentation	1.41142909
32	MP0008789_abnormal_olfactory_epithelium	1.39828367
33	MP0003937_abnormal_limbs/digits/tail_de	1.38712324
34	MP0003121_genomic_imprinting	1.38388987
35	MP0004142_abnormal_muscle_tone	1.38154325
36	MP0005645_abnormal_hypothalamus_physiol	1.37482913
37	MP0001293_anophthalmia	1.37188734
38	MP0002272_abnormal_nervous_system	1.36437411
39	MP0002160_abnormal_reproductive_system	1.34660010
40	MP0003890_abnormal_embryonic-extraembry	1.34394290
41	MP0000778_abnormal_nervous_system	1.32164453
42	MP0000566_synostosis	1.26052685
43	MP0004133_heterotaxia	1.24899545
44	MP0003880_abnormal_central_pattern	1.24488569
45	MP0003718_maternal_effect	1.21365485
46	MP0005389_reproductive_system_phenotype	1.21250924
47	MP0001919_abnormal_reproductive_system	1.20612454
48	MP0002638_abnormal_pupillary_reflex	1.19675196
49	MP0001501_abnormal_sleep_pattern	1.18775397
50	MP0000383_abnormal_hair_follicle	1.18645300
51	MP0000516_abnormal_urinary_system	1.18131867
52	MP0005367_renal/urinary_system_phenotyp	1.18131867
53	MP0005171_absent_coat_pigmentation	1.17615388
54	MP0002557_abnormal_social/conspecific_i	1.17565115
55	MP0005499_abnormal_olfactory_system	1.16717082
56	MP0005394_taste/olfaction_phenotype	1.16717082
57	MP0003938_abnormal_ear_development	1.15969071
58	MP0008872_abnormal_physiological_respon	1.14117783
59	MP0005187_abnormal_penis_morphology	1.13368907
60	MP0003119_abnormal_digestive_system	1.10395379
61	MP0002572_abnormal_emotion/affect_behav	1.10245060
62	MP0003698_abnormal_male_reproductive	1.08944293
63	MP0003283_abnormal_digestive_organ	1.07195793
64	MP0002282_abnormal_trachea_morphology	1.06445445
65	MP0003045_fibrosis	1.06323939
66	MP0008057_abnormal_DNA_replication	1.05859777
67	MP0001529_abnormal_vocalization	1.04487245
68	MP0001929_abnormal_gametogenesis	1.02802611
69	MP0005410_abnormal_fertilization	1.01959071
70	MP0000049_abnormal_middle_ear	1.00896896
71	MP0001324_abnormal_eye_pigmentation	1.00272230
72	MP0001286_abnormal_eye_development	0.99562823
73	MP0003755_abnormal_palate_morphology	0.99362874
74	MP0003635_abnormal_synaptic_transmissio	0.99224991
75	MP0004924_abnormal_behavior	0.98206849
76	MP0005386_behavior/neurological_phenoty	0.98206849
77	MP0002067_abnormal_sensory_capabilities	0.97689476
78	MP0005167_abnormal_blood-brain_barrier	0.97130588
79	MP0002064_seizures	0.96018449
80	MP0005391_vision/eye_phenotype	0.94322466
81	MP0008058_abnormal_DNA_repair	0.93004581
82	MP0002063_abnormal_learning/memory/cond	0.92042254
83	MP0004742_abnormal_vestibular_system	0.91747599
84	MP0002184_abnormal_innervation	0.91109327
85	MP0000026_abnormal_inner_ear	0.90963417
86	MP0002735_abnormal_chemical_nociception	0.90423490
87	MP0006276_abnormal_autonomic_nervous	0.90118609
88	MP0002752_abnormal_somatic_nervous	0.89627894
89	MP0002109_abnormal_limb_morphology	0.89482806
90	MP0005195_abnormal_posterior_eye	0.88515078
91	MP0001986_abnormal_taste_sensitivity	0.87497032
92	MP0005075_abnormal_melanosome_morpholog	0.87481120
93	MP0002168_other_aberrant_phenotype	0.87285801
94	MP0000427_abnormal_hair_cycle	0.86871797
95	MP0010368_abnormal_lymphatic_system	0.85002044
96	MP0000955_abnormal_spinal_cord	0.84963077
97	MP0003567_abnormal_fetal_cardiomyocyte	0.83934374
98	MP0005377_hearing/vestibular/ear_phenot	0.79462937
99	MP0003878_abnormal_ear_physiology	0.79462937
100	MP0000653_abnormal_sex_gland	0.78997405

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.71592494
2	Pancreatic fibrosis (HP:0100732)	4.20592257
3	True hermaphroditism (HP:0010459)	4.11172136
4	Abnormality of midbrain morphology (HP:0002418)	3.66182110
5	Molar tooth sign on MRI (HP:0002419)	3.66182110
6	Nephronophthisis (HP:0000090)	3.63506981
7	Abnormality of the renal cortex (HP:0011035)	3.46485970
8	Abnormality of the renal medulla (HP:0100957)	3.29764311
9	Chronic hepatic failure (HP:0100626)	3.10792789
10	Cystic liver disease (HP:0006706)	3.06377404
11	Ectopic kidney (HP:0000086)	2.91557316
12	Tubular atrophy (HP:0000092)	2.83297876
13	Hyperventilation (HP:0002883)	2.61683267
14	Medial flaring of the eyebrow (HP:0010747)	2.60353721
15	Congenital stationary night blindness (HP:0007642)	2.56685692
16	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.56478650
17	Gaze-evoked nystagmus (HP:0000640)	2.54001487
18	Polydipsia (HP:0001959)	2.52349330
19	Abnormal drinking behavior (HP:0030082)	2.52349330
20	Type II lissencephaly (HP:0007260)	2.46804713
21	Sclerocornea (HP:0000647)	2.46758325
22	Intestinal atresia (HP:0011100)	2.44812899
23	Renal cortical cysts (HP:0000803)	2.42232608
24	Progressive cerebellar ataxia (HP:0002073)	2.40968208
25	Postaxial foot polydactyly (HP:0001830)	2.35371936
26	Abnormal respiratory motile cilium morphology (HP:0005938)	2.31893027
27	Abnormal respiratory epithelium morphology (HP:0012253)	2.31893027
28	Abnormal ciliary motility (HP:0012262)	2.29719875
29	Absent/shortened dynein arms (HP:0200106)	2.29688212
30	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.29688212
31	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.28644076
32	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.27415096
33	Volvulus (HP:0002580)	2.25567213
34	Abnormal respiratory motile cilium physiology (HP:0012261)	2.22210702
35	Abnormality of the ileum (HP:0001549)	2.21740085
36	Congenital hepatic fibrosis (HP:0002612)	2.20782857
37	Male pseudohermaphroditism (HP:0000037)	2.19745765
38	Anophthalmia (HP:0000528)	2.19274472
39	Gait imbalance (HP:0002141)	2.16957914
40	Polyuria (HP:0000103)	2.15406763
41	Congenital primary aphakia (HP:0007707)	2.13503876
42	Abolished electroretinogram (ERG) (HP:0000550)	2.12685554
43	Bile duct proliferation (HP:0001408)	2.11949352
44	Abnormal biliary tract physiology (HP:0012439)	2.11949352
45	Genital tract atresia (HP:0001827)	2.10489315
46	Meckel diverticulum (HP:0002245)	2.09166768
47	Postaxial hand polydactyly (HP:0001162)	2.07730686
48	Neoplasm of the adrenal cortex (HP:0100641)	2.07670432
49	Cerebellar dysplasia (HP:0007033)	2.07103319
50	Optic nerve hypoplasia (HP:0000609)	2.06865138
51	Occipital encephalocele (HP:0002085)	2.06211925
52	Absent speech (HP:0001344)	2.06003942
53	Abnormality of chromosome stability (HP:0003220)	2.05603757
54	Chromsome breakage (HP:0040012)	2.05365572
55	Anencephaly (HP:0002323)	2.05202743
56	Genetic anticipation (HP:0003743)	2.04419981
57	Lissencephaly (HP:0001339)	2.04365220
58	Vaginal atresia (HP:0000148)	2.01108989
59	Abnormality of the nasal septum (HP:0000419)	2.00251966
60	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.00091362
61	Focal motor seizures (HP:0011153)	1.99396664
62	Hemiparesis (HP:0001269)	1.97334410
63	Abnormality of the pubic bones (HP:0003172)	1.96878968
64	Febrile seizures (HP:0002373)	1.95484666
65	Chromosomal breakage induced by crosslinking agents (HP:0003221)	1.94513339
66	Enlarged kidneys (HP:0000105)	1.94284632
67	Large for gestational age (HP:0001520)	1.94214987
68	Focal seizures (HP:0007359)	1.94144959
69	Keratoconus (HP:0000563)	1.92794672
70	Increased corneal curvature (HP:0100692)	1.92794672
71	Nephrogenic diabetes insipidus (HP:0009806)	1.91462611
72	Sloping forehead (HP:0000340)	1.90965377
73	Furrowed tongue (HP:0000221)	1.89044412
74	Preaxial hand polydactyly (HP:0001177)	1.87789753
75	Attenuation of retinal blood vessels (HP:0007843)	1.87678024
76	Stomach cancer (HP:0012126)	1.87504627
77	Atonic seizures (HP:0010819)	1.86539090
78	Broad-based gait (HP:0002136)	1.86427235
79	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.83864396
80	Dandy-Walker malformation (HP:0001305)	1.83767636
81	Abnormality of DNA repair (HP:0003254)	1.82605802
82	Median cleft lip (HP:0000161)	1.82329757
83	Highly arched eyebrow (HP:0002553)	1.82289834
84	Preaxial foot polydactyly (HP:0001841)	1.82128115
85	Protruding tongue (HP:0010808)	1.80982070
86	Dialeptic seizures (HP:0011146)	1.80782687
87	Gastrointestinal atresia (HP:0002589)	1.78996445
88	Hypoplastic iliac wings (HP:0002866)	1.78862033
89	Rhinitis (HP:0012384)	1.77773794
90	Hypothermia (HP:0002045)	1.75536059
91	Small hand (HP:0200055)	1.74537769
92	Poor coordination (HP:0002370)	1.74203355
93	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	1.73840200
94	Pachygyria (HP:0001302)	1.73752038
95	Tubulointerstitial abnormality (HP:0001969)	1.72936736
96	Abnormal urine output (HP:0012590)	1.71826451
97	Septo-optic dysplasia (HP:0100842)	1.71660979
98	Short foot (HP:0001773)	1.70139470
99	Tented upper lip vermilion (HP:0010804)	1.68346547
100	Astigmatism (HP:0000483)	1.68182706

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.43043778
2	PINK1	3.43271431
3	TNIK	3.04991638
4	PNCK	2.93475552
5	BMPR1B	2.86420244
6	ACVR1B	2.36500543
7	CASK	2.30065057
8	ZAK	2.16745250
9	WNK3	2.12707285
10	WNK4	2.09200549
11	STK38L	1.99199980
12	NLK	1.96698111
13	STK39	1.96654110
14	GRK1	1.86875155
15	MAPK13	1.84423413
16	LATS1	1.77146438
17	NUAK1	1.74632199
18	WEE1	1.69185093
19	ADRBK2	1.60431809
20	AKT3	1.55434260
21	BRSK2	1.49202397
22	MKNK2	1.47912241
23	STK24	1.42656498
24	MAP4K2	1.34688004
25	MARK3	1.30775335
26	NTRK3	1.19976178
27	FGFR2	1.19682529
28	NEK2	1.17661196
29	MAPK15	1.15102139
30	INSRR	1.10330557
31	SGK2	1.10155686
32	PLK2	1.04655824
33	CCNB1	1.04558135
34	PLK4	1.03281140
35	ERBB3	1.02961562
36	EPHA4	1.00840384
37	MAPKAPK3	1.00698064
38	TAOK3	0.99681585
39	MAP3K4	0.97541506
40	CDC7	0.96627222
41	DYRK2	0.95201806
42	NTRK2	0.95177714
43	TGFBR1	0.92397570
44	TRIM28	0.91742327
45	PAK3	0.91180481
46	CSNK1G1	0.90649606
47	TXK	0.88222992
48	MAP2K7	0.85520514
49	MARK1	0.84512058
50	SGK494	0.83510542
51	SGK223	0.83510542
52	PLK3	0.81890224
53	BCR	0.81038448
54	CSNK1G2	0.80649367
55	MAPKAPK5	0.79745271
56	MKNK1	0.79216121
57	CAMK1G	0.78311827
58	PRKCE	0.77381338
59	CSNK1A1L	0.76192218
60	OXSR1	0.71124054
61	PRKCG	0.71025326
62	STK3	0.66208569
63	CSNK1G3	0.64965436
64	MELK	0.62792822
65	CHEK2	0.59793838
66	CDK3	0.59437632
67	EIF2AK3	0.59344022
68	ATM	0.56948478
69	WNK1	0.56537947
70	PRKCQ	0.56529899
71	TIE1	0.56331559
72	CAMK1	0.54984874
73	FLT3	0.52408399
74	PIK3CA	0.52091377
75	VRK1	0.51787663
76	ADRBK1	0.50813833
77	SIK2	0.49924993
78	MAP3K2	0.49014045
79	OBSCN	0.48683180
80	PLK1	0.47305775
81	ATR	0.46021623
82	DAPK2	0.45930282
83	PRKD3	0.43530949
84	PRKAA2	0.42077190
85	CDK9	0.41811133
86	PKN1	0.41652049
87	CSNK1D	0.40969913
88	MINK1	0.40926626
89	CAMK4	0.40758774
90	ERBB2	0.40541040
91	SGK1	0.40118449
92	CAMKK2	0.39696879
93	TEC	0.39660931
94	CSNK1A1	0.38221508
95	SGK3	0.37494878
96	TRPM7	0.33815290
97	TTK	0.33290973
98	CAMK1D	0.32421712
99	PHKG1	0.31295346
100	PHKG2	0.31295346

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phototransduction_Homo sapiens_hsa04744	2.80149788
2	Nitrogen metabolism_Homo sapiens_hsa00910	2.79842060
3	Butanoate metabolism_Homo sapiens_hsa00650	2.53245976
4	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.40383332
5	Nicotine addiction_Homo sapiens_hsa05033	2.29426813
6	Fanconi anemia pathway_Homo sapiens_hsa03460	2.27654416
7	Homologous recombination_Homo sapiens_hsa03440	2.27643951
8	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.19015958
9	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.10839886
10	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.98646149
11	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.89805003
12	Lysine degradation_Homo sapiens_hsa00310	1.80989972
13	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.78886502
14	Non-homologous end-joining_Homo sapiens_hsa03450	1.73593851
15	Olfactory transduction_Homo sapiens_hsa04740	1.69485938
16	Selenocompound metabolism_Homo sapiens_hsa00450	1.69253522
17	Basal transcription factors_Homo sapiens_hsa03022	1.67610238
18	Taste transduction_Homo sapiens_hsa04742	1.62983262
19	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.60873967
20	Tryptophan metabolism_Homo sapiens_hsa00380	1.60748970
21	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.59448407
22	Propanoate metabolism_Homo sapiens_hsa00640	1.58808497
23	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.45160469
24	Basal cell carcinoma_Homo sapiens_hsa05217	1.40458808
25	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.40290586
26	Circadian entrainment_Homo sapiens_hsa04713	1.37589310
27	Protein export_Homo sapiens_hsa03060	1.36842066
28	RNA degradation_Homo sapiens_hsa03018	1.34293609
29	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.34283087
30	Linoleic acid metabolism_Homo sapiens_hsa00591	1.32083235
31	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.28703266
32	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.26243579
33	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.25826244
34	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.25052681
35	ABC transporters_Homo sapiens_hsa02010	1.24526804
36	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.20922793
37	Glutamatergic synapse_Homo sapiens_hsa04724	1.18100432
38	RNA polymerase_Homo sapiens_hsa03020	1.17091007
39	Morphine addiction_Homo sapiens_hsa05032	1.16650328
40	Steroid biosynthesis_Homo sapiens_hsa00100	1.15644048
41	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.09019414
42	Ether lipid metabolism_Homo sapiens_hsa00565	1.08316424
43	Salivary secretion_Homo sapiens_hsa04970	1.06102936
44	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.04967911
45	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.03926130
46	Hippo signaling pathway_Homo sapiens_hsa04390	1.02970783
47	Glycerolipid metabolism_Homo sapiens_hsa00561	1.02857245
48	GABAergic synapse_Homo sapiens_hsa04727	1.01218632
49	Peroxisome_Homo sapiens_hsa04146	1.00778738
50	Insulin secretion_Homo sapiens_hsa04911	1.00714427
51	Chemical carcinogenesis_Homo sapiens_hsa05204	1.00277492
52	Serotonergic synapse_Homo sapiens_hsa04726	0.92507825
53	Dopaminergic synapse_Homo sapiens_hsa04728	0.91578701
54	beta-Alanine metabolism_Homo sapiens_hsa00410	0.89228691
55	Nucleotide excision repair_Homo sapiens_hsa03420	0.82750465
56	Calcium signaling pathway_Homo sapiens_hsa04020	0.81924017
57	Regulation of autophagy_Homo sapiens_hsa04140	0.78906401
58	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.78551000
59	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.77756442
60	Amphetamine addiction_Homo sapiens_hsa05031	0.77284543
61	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.76501579
62	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.74954504
63	Histidine metabolism_Homo sapiens_hsa00340	0.74308132
64	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.69568410
65	One carbon pool by folate_Homo sapiens_hsa00670	0.69282997
66	Wnt signaling pathway_Homo sapiens_hsa04310	0.68874461
67	cAMP signaling pathway_Homo sapiens_hsa04024	0.67865276
68	Cocaine addiction_Homo sapiens_hsa05030	0.67211236
69	Circadian rhythm_Homo sapiens_hsa04710	0.66917851
70	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.64335303
71	Fatty acid degradation_Homo sapiens_hsa00071	0.63158708
72	Renin secretion_Homo sapiens_hsa04924	0.63002799
73	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.62672032
74	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.62576228
75	Retinol metabolism_Homo sapiens_hsa00830	0.61232096
76	Long-term depression_Homo sapiens_hsa04730	0.60755018
77	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.59536945
78	Sphingolipid metabolism_Homo sapiens_hsa00600	0.59104003
79	Fatty acid metabolism_Homo sapiens_hsa01212	0.55946085
80	Gastric acid secretion_Homo sapiens_hsa04971	0.55484647
81	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.55346827
82	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.54758968
83	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.54145467
84	Fat digestion and absorption_Homo sapiens_hsa04975	0.53953836
85	Purine metabolism_Homo sapiens_hsa00230	0.52575986
86	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.52441967
87	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.49758901
88	Melanogenesis_Homo sapiens_hsa04916	0.49148846
89	Cholinergic synapse_Homo sapiens_hsa04725	0.47106358
90	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.46744312
91	Axon guidance_Homo sapiens_hsa04360	0.46064698
92	Pyrimidine metabolism_Homo sapiens_hsa00240	0.45364447
93	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.44681960
94	Caffeine metabolism_Homo sapiens_hsa00232	0.43741538
95	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.41606188
96	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.39795006
97	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.38454344
98	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.36364326
99	p53 signaling pathway_Homo sapiens_hsa04115	0.35762967
100	Metabolic pathways_Homo sapiens_hsa01100	0.35636908

LRRC37BP1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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