LRRC38

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of retinoic acid receptor signaling pathway (GO:0048387)8.27234780
2actin-myosin filament sliding (GO:0033275)7.82684627
3muscle filament sliding (GO:0030049)7.82684627
4sarcoplasmic reticulum calcium ion transport (GO:0070296)7.25184684
5regulation of skeletal muscle contraction (GO:0014819)7.10908389
6regulation of retinoic acid receptor signaling pathway (GO:0048385)6.75496231
7skeletal muscle contraction (GO:0003009)6.49489702
8actin-mediated cell contraction (GO:0070252)6.47020634
9membrane depolarization during cardiac muscle cell action potential (GO:0086012)6.13784288
10neuronal action potential propagation (GO:0019227)5.95354665
11regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)5.59071408
12relaxation of smooth muscle (GO:0044557)5.55863379
13sodium ion export (GO:0071436)5.52454199
14negative regulation of cytosolic calcium ion concentration (GO:0051481)5.45646143
15positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)5.40848350
16cell communication by electrical coupling involved in cardiac conduction (GO:0086064)5.19600687
17striated muscle contraction (GO:0006941)5.06977989
18skeletal muscle tissue regeneration (GO:0043403)4.96927001
19skeletal muscle adaptation (GO:0043501)4.81859343
20actin filament-based movement (GO:0030048)4.76761812
21tricarboxylic acid cycle (GO:0006099)4.60059345
22cardiac myofibril assembly (GO:0055003)4.59731364
23skeletal muscle tissue development (GO:0007519)4.51089375
24NADH metabolic process (GO:0006734)4.50456337
25actomyosin structure organization (GO:0031032)4.48992472
26membrane depolarization during action potential (GO:0086010)4.45211980
27glycogen catabolic process (GO:0005980)4.44293260
28response to activity (GO:0014823)4.42330521
29cell communication by electrical coupling (GO:0010644)4.41972058
30striated muscle atrophy (GO:0014891)4.27811931
31purine nucleotide salvage (GO:0032261)4.21202875
32oxaloacetate metabolic process (GO:0006107)4.21176197
33cardiac muscle contraction (GO:0060048)4.20153098
34glucan catabolic process (GO:0009251)4.12955489
35regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.10974247
36carnitine shuttle (GO:0006853)4.08323446
37cardiac muscle hypertrophy (GO:0003300)4.05811265
38regulation of cell communication by electrical coupling (GO:0010649)4.03671694
39skeletal muscle fiber development (GO:0048741)4.02099055
40glycolytic process (GO:0006096)4.01818774
41striated muscle hypertrophy (GO:0014897)3.98760740
42synaptic vesicle exocytosis (GO:0016079)3.94409588
43cellular polysaccharide catabolic process (GO:0044247)3.94325678
44negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.93497543
45relaxation of muscle (GO:0090075)3.92603170
46muscle cell fate commitment (GO:0042693)3.91283492
47muscle atrophy (GO:0014889)3.87919352
48muscle adaptation (GO:0043500)3.87436563
49sarcomere organization (GO:0045214)3.85083882
50calcium ion import (GO:0070509)3.84064213
51regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.83006585
52muscle structure development (GO:0061061)3.82237261
53pyrimidine ribonucleoside catabolic process (GO:0046133)3.82067717
54response to muscle activity (GO:0014850)3.81905968
55succinate metabolic process (GO:0006105)3.80767653
56muscle organ development (GO:0007517)3.80687552
57positive regulation of myotube differentiation (GO:0010831)3.79403046
58fructose metabolic process (GO:0006000)3.75640442
59muscle contraction (GO:0006936)3.72200059
60polysaccharide catabolic process (GO:0000272)3.70535506
61G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.63128037
62myotube cell development (GO:0014904)3.58243124
63regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.57608398
64plasma membrane repair (GO:0001778)3.57573642
65muscle hypertrophy (GO:0014896)3.57081093
66gluconeogenesis (GO:0006094)3.54244075
67muscle fiber development (GO:0048747)3.49787497
68striated muscle cell development (GO:0055002)3.45888841
69muscle organ morphogenesis (GO:0048644)3.43011779
70myofibril assembly (GO:0030239)3.42490616
71negative regulation of calcium ion transmembrane transport (GO:1903170)3.39008304
72negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.39008304
73mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.38331834
74muscle system process (GO:0003012)3.38089332
75positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.36204178
76cellular sodium ion homeostasis (GO:0006883)3.35609689
77cellular potassium ion homeostasis (GO:0030007)3.33548483
78synaptic vesicle maturation (GO:0016188)3.32333232
79neuromuscular synaptic transmission (GO:0007274)3.31753939
80muscle cell cellular homeostasis (GO:0046716)3.31704228
81lactate metabolic process (GO:0006089)3.30312130
82creatine metabolic process (GO:0006600)3.27680646
83negative regulation of potassium ion transmembrane transport (GO:1901380)3.27586461
84response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.25053631
85mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.24600446
86gamma-aminobutyric acid signaling pathway (GO:0007214)3.24061757
87fatty acid transmembrane transport (GO:1902001)3.23521666
88striated muscle adaptation (GO:0014888)3.22284507
89regulation of sarcomere organization (GO:0060297)3.22079867
90negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)3.21309662
91cardiac muscle hypertrophy in response to stress (GO:0014898)3.19150774
92muscle hypertrophy in response to stress (GO:0003299)3.19150774
93cardiac muscle adaptation (GO:0014887)3.19150774
94oxidative phosphorylation (GO:0006119)3.18856075
95glucan biosynthetic process (GO:0009250)3.18370939
96glycogen biosynthetic process (GO:0005978)3.18370939
97AMP metabolic process (GO:0046033)3.17914153
98regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.15804704
99respiratory electron transport chain (GO:0022904)3.15320059
100regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.14078933
101IMP metabolic process (GO:0046040)3.13920012
102negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.13369246
103hexose biosynthetic process (GO:0019319)3.12875711
104pyruvate metabolic process (GO:0006090)3.09119494
105ADP metabolic process (GO:0046031)3.08983671
106negative regulation of muscle contraction (GO:0045932)3.08591089
107relaxation of cardiac muscle (GO:0055119)3.08127877
108muscle cell development (GO:0055001)3.07354216
109response to caffeine (GO:0031000)3.06971913
110regulation of skeletal muscle cell differentiation (GO:2001014)3.06304209
111positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.05919847
112regulation of myoblast differentiation (GO:0045661)3.05070271
113glycogen metabolic process (GO:0005977)3.04068180
114electron transport chain (GO:0022900)3.03667273
115regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.03548130
116regulation of striated muscle contraction (GO:0006942)3.03033805
117regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.02704008
118energy coupled proton transport, down electrochemical gradient (GO:0015985)3.01890113
119ATP synthesis coupled proton transport (GO:0015986)3.01890113
120striated muscle tissue development (GO:0014706)3.00266651
121cellular glucan metabolic process (GO:0006073)2.97058948
122glucan metabolic process (GO:0044042)2.97058948
1232-oxoglutarate metabolic process (GO:0006103)2.96711363
124heart process (GO:0003015)2.96204757
125heart contraction (GO:0060047)2.96204757
126regulation of cofactor metabolic process (GO:0051193)2.95918089
127regulation of coenzyme metabolic process (GO:0051196)2.95918089
128regulation of acyl-CoA biosynthetic process (GO:0050812)2.94245232
129cardiac muscle cell development (GO:0055013)2.93999147
130regulation of membrane repolarization (GO:0060306)2.92312743
131mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.89695797
132regulation of calcium ion transmembrane transport (GO:1903169)2.89650749
133regulation of calcium ion transmembrane transporter activity (GO:1901019)2.89650749
134regulation of short-term neuronal synaptic plasticity (GO:0048172)2.87456020
135regulation of muscle system process (GO:0090257)2.86164245
136positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.85576424
137muscle tissue morphogenesis (GO:0060415)2.85428052
138myoblast fusion (GO:0007520)2.83828320
139response to inactivity (GO:0014854)2.83586762
140cell communication involved in cardiac conduction (GO:0086065)2.82891721
141retinal rod cell development (GO:0046548)2.81899414
142positive regulation of cation channel activity (GO:2001259)2.80166052
143regulation of relaxation of muscle (GO:1901077)2.77286847
144regulation of actin filament-based movement (GO:1903115)2.76761277
145calcium ion transport into cytosol (GO:0060402)2.76634185
146detection of light stimulus involved in visual perception (GO:0050908)2.76391072
147detection of light stimulus involved in sensory perception (GO:0050962)2.76391072

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.70515030
2GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.66580731
3EZH2_22144423_ChIP-Seq_EOC_Human3.63021361
4IGF1R_20145208_ChIP-Seq_DFB_Human3.20205507
5ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.86987717
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.79654401
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.69552484
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.60695870
9SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.59674920
10* EZH2_27304074_Chip-Seq_ESCs_Mouse2.37002589
11JARID2_20064375_ChIP-Seq_MESCs_Mouse2.35276788
12EZH2_27294783_Chip-Seq_ESCs_Mouse2.32749084
13* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.29425815
14* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.19745034
15* REST_21632747_ChIP-Seq_MESCs_Mouse2.19200045
16BP1_19119308_ChIP-ChIP_Hs578T_Human2.16968340
17DROSHA_22980978_ChIP-Seq_HELA_Human2.15869019
18EZH2_18974828_ChIP-Seq_MESCs_Mouse2.13882815
19RNF2_18974828_ChIP-Seq_MESCs_Mouse2.13882815
20MTF2_20144788_ChIP-Seq_MESCs_Mouse2.12997553
21* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.07793628
22SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.07138305
23CTBP1_25329375_ChIP-Seq_LNCAP_Human2.06706407
24REST_18959480_ChIP-ChIP_MESCs_Mouse2.00993340
25SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.98674081
26RARB_27405468_Chip-Seq_BRAIN_Mouse1.89065581
27VDR_22108803_ChIP-Seq_LS180_Human1.88588944
28CBX2_27304074_Chip-Seq_ESCs_Mouse1.79953706
29GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.78032597
30BMI1_23680149_ChIP-Seq_NPCS_Mouse1.77144579
31SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.74687141
32AR_21572438_ChIP-Seq_LNCaP_Human1.73145422
33RNF2_27304074_Chip-Seq_ESCs_Mouse1.72968650
34ZNF274_21170338_ChIP-Seq_K562_Hela1.72361080
35PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.69319173
36EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.69055125
37TAF15_26573619_Chip-Seq_HEK293_Human1.66584901
38ERG_21242973_ChIP-ChIP_JURKAT_Human1.63090024
39FUS_26573619_Chip-Seq_HEK293_Human1.61484435
40SMAD4_21799915_ChIP-Seq_A2780_Human1.59578412
41ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.58871442
42LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.58042204
43EED_16625203_ChIP-ChIP_MESCs_Mouse1.57806533
44CTBP2_25329375_ChIP-Seq_LNCAP_Human1.52889145
45ZFP57_27257070_Chip-Seq_ESCs_Mouse1.52503087
46NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.47423549
47OCT4_20526341_ChIP-Seq_ESCs_Human1.47415269
48TOP2B_26459242_ChIP-Seq_MCF-7_Human1.43827720
49ESR1_20079471_ChIP-ChIP_T-47D_Human1.43088336
50SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.42711955
51P53_22127205_ChIP-Seq_FIBROBLAST_Human1.42678028
52EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.41999565
53SOX2_21211035_ChIP-Seq_LN229_Gbm1.38652409
54EP300_21415370_ChIP-Seq_HL-1_Mouse1.37522185
55CDX2_19796622_ChIP-Seq_MESCs_Mouse1.36431264
56HTT_18923047_ChIP-ChIP_STHdh_Human1.32128365
57POU3F2_20337985_ChIP-ChIP_501MEL_Human1.29720731
58SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.27298575
59FLI1_27457419_Chip-Seq_LIVER_Mouse1.26538519
60NANOG_19829295_ChIP-Seq_ESCs_Human1.26004001
61SOX2_19829295_ChIP-Seq_ESCs_Human1.26004001
62UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.25825641
63STAT1_20625510_ChIP-Seq_HELA_Human1.25506167
64RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24712135
65CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.23917847
66AR_19668381_ChIP-Seq_PC3_Human1.23411249
67ER_23166858_ChIP-Seq_MCF-7_Human1.22788819
68PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.22615396
69STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.20569556
70CBP_20019798_ChIP-Seq_JUKART_Human1.19296380
71IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.19296380
72BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.18995697
73CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.18627033
74EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.17903276
75TP53_20018659_ChIP-ChIP_R1E_Mouse1.17733447
76SMAD4_21741376_ChIP-Seq_EPCs_Human1.16654817
77P300_19829295_ChIP-Seq_ESCs_Human1.15972289
78SMAD3_21741376_ChIP-Seq_EPCs_Human1.14754630
79PHF8_20622853_ChIP-Seq_HELA_Human1.12444760
80CRX_20693478_ChIP-Seq_RETINA_Mouse1.12396980
81TBL1_22424771_ChIP-Seq_293T_Human1.12301790
82CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.11957868
83NANOG_20526341_ChIP-Seq_ESCs_Human1.11712550
84PCGF2_27294783_Chip-Seq_ESCs_Mouse1.11372483
85PIAS1_25552417_ChIP-Seq_VCAP_Human1.11228315
86PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.10914563
87TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.09630272
88SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.09610107
89SMAD4_21741376_ChIP-Seq_HESCs_Human1.08761964
90BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.08707708
91POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.07972350
92TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07972350
93PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.07757596
94AUTS2_25519132_ChIP-Seq_293T-REX_Human1.07210768
95NFYB_21822215_ChIP-Seq_K562_Human1.06271093
96TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05364229
97RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.04624621
98AR_25329375_ChIP-Seq_VCAP_Human1.04495704
99SUZ12_27294783_Chip-Seq_NPCs_Mouse1.03669828
100CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.03437499
101STAT3_23295773_ChIP-Seq_U87_Human1.02695267
102VDR_24787735_ChIP-Seq_THP-1_Human1.02389811
103CTCF_27219007_Chip-Seq_Bcells_Human1.02032989
104CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.01637082
105RING1B_27294783_Chip-Seq_ESCs_Mouse1.00850100
106GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.00496698
107FLI1_21867929_ChIP-Seq_TH2_Mouse1.00431778
108OCT4_21477851_ChIP-Seq_ESCs_Mouse0.98841987
109ETV1_20927104_ChIP-Seq_GIST48_Human0.98785676
110YAP1_20516196_ChIP-Seq_MESCs_Mouse0.97915618
111EZH2_27294783_Chip-Seq_NPCs_Mouse0.97716597
112ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.97445888
113RNF2_27304074_Chip-Seq_NSC_Mouse0.97417917
114NR3C1_21868756_ChIP-Seq_MCF10A_Human0.97267666
115RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.96872724
116SMAD3_21741376_ChIP-Seq_HESCs_Human0.96551116
117DNAJC2_21179169_ChIP-ChIP_NT2_Human0.96332877
118MYC_27129775_Chip-Seq_CORNEA_Mouse0.95880915
119RAC3_21632823_ChIP-Seq_H3396_Human0.95535971
120ARNT_22903824_ChIP-Seq_MCF-7_Human0.94488196
121RBPJ_21746931_ChIP-Seq_IB4_Human0.93708230
122HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.93440636
123BCAT_22108803_ChIP-Seq_LS180_Human0.93198270
124HNFA_21074721_ChIP-Seq_CACO-2_Human0.92232135
125CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.92213396
126PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.91749059
127TCF4_23295773_ChIP-Seq_U87_Human0.91513687
128KLF5_20875108_ChIP-Seq_MESCs_Mouse0.91128037
129MYC_19829295_ChIP-Seq_ESCs_Human0.91093289
130SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.90999861
131CBP_21632823_ChIP-Seq_H3396_Human0.90458786
132TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.90219285
133PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.90214074
134SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.90141635
135HOXB7_26014856_ChIP-Seq_BT474_Human0.90122351
136FOXH1_21741376_ChIP-Seq_ESCs_Human0.89624004
137TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.89615852
138KDM2B_26808549_Chip-Seq_REH_Human0.89198358
139TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.89090778
140GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.89045715
141OCT4_19829295_ChIP-Seq_ESCs_Human0.88054663
142ZFP281_18757296_ChIP-ChIP_E14_Mouse0.87741966
143NR3C1_23031785_ChIP-Seq_PC12_Mouse0.87518048
144OCT1_27270436_Chip-Seq_PROSTATE_Human0.87358619
145TBX20_22328084_ChIP-Seq_HEART_Mouse0.87304473
146TBX20_22080862_ChIP-Seq_HEART_Mouse0.87304473
147CJUN_26792858_Chip-Seq_BT549_Human0.86965927
148LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85524603

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004145_abnormal_muscle_electrophysio6.62940376
2MP0003646_muscle_fatigue5.14391793
3MP0000749_muscle_degeneration4.89874569
4MP0000751_myopathy4.18586726
5MP0004036_abnormal_muscle_relaxation4.05854681
6MP0005451_abnormal_body_composition3.40028676
7MP0004233_abnormal_muscle_weight3.35492183
8MP0000747_muscle_weakness3.30647499
9MP0002106_abnormal_muscle_physiology3.08563458
10MP0002837_dystrophic_cardiac_calcinosis2.89895144
11MP0002269_muscular_atrophy2.82797089
12MP0000759_abnormal_skeletal_muscle2.77583858
13MP0004084_abnormal_cardiac_muscle2.74093485
14MP0005620_abnormal_muscle_contractility2.61454404
15MP0004087_abnormal_muscle_fiber2.56461483
16MP0005369_muscle_phenotype2.56124736
17MP0004130_abnormal_muscle_cell2.37998182
18MP0002332_abnormal_exercise_endurance2.35050825
19MP0009046_muscle_twitch2.23572063
20MP0004859_abnormal_synaptic_plasticity2.20067733
21MP0004215_abnormal_myocardial_fiber2.19214735
22MP0006036_abnormal_mitochondrial_physio2.07729947
23MP0006035_abnormal_mitochondrial_morpho1.93974187
24MP0003221_abnormal_cardiomyocyte_apopto1.83813507
25MP0004270_analgesia1.79225639
26MP0003635_abnormal_synaptic_transmissio1.67684669
27MP0003136_yellow_coat_color1.66558520
28MP0005551_abnormal_eye_electrophysiolog1.65238982
29MP0008775_abnormal_heart_ventricle1.64884298
30MP0002127_abnormal_cardiovascular_syste1.57928433
31MP0002064_seizures1.55228318
32MP0000750_abnormal_muscle_regeneration1.53930975
33MP0004510_myositis1.53413516
34MP0004484_altered_response_of1.45427043
35MP0008569_lethality_at_weaning1.39596070
36MP0002272_abnormal_nervous_system1.39315545
37MP0009745_abnormal_behavioral_response1.36866614
38MP0002090_abnormal_vision1.34583305
39MP0001486_abnormal_startle_reflex1.30715518
40MP0000013_abnormal_adipose_tissue1.30297615
41MP0003806_abnormal_nucleotide_metabolis1.30142935
42MP0002972_abnormal_cardiac_muscle1.26607719
43MP0002067_abnormal_sensory_capabilities1.25985464
44MP0002108_abnormal_muscle_morphology1.25658790
45MP0005623_abnormal_meninges_morphology1.25472059
46MP0006072_abnormal_retinal_apoptosis1.24425761
47MP0005167_abnormal_blood-brain_barrier1.22773406
48MP0003880_abnormal_central_pattern1.18526742
49MP0002063_abnormal_learning/memory/cond1.17921388
50MP0004142_abnormal_muscle_tone1.16119327
51MP0002822_catalepsy1.14613373
52MP0002734_abnormal_mechanical_nocicepti1.13093288
53MP0005266_abnormal_metabolism1.11183950
54MP0005330_cardiomyopathy1.08280009
55MP0003137_abnormal_impulse_conducting1.07026761
56MP0004085_abnormal_heartbeat1.05472922
57MP0009780_abnormal_chondrocyte_physiolo1.04831162
58MP0003879_abnormal_hair_cell1.04411916
59MP0004043_abnormal_pH_regulation1.02928173
60MP0004858_abnormal_nervous_system1.02668772
61MP0009840_abnormal_foam_cell1.01453717
62MP0005410_abnormal_fertilization0.98394139
63MP0003045_fibrosis0.96154470
64MP0005171_absent_coat_pigmentation0.92443931
65MP0002572_abnormal_emotion/affect_behav0.91495897
66MP0001501_abnormal_sleep_pattern0.89862995
67MP0003122_maternal_imprinting0.87688830
68MP0001440_abnormal_grooming_behavior0.86590059
69MP0001968_abnormal_touch/_nociception0.86199304
70MP0002066_abnormal_motor_capabilities/c0.86064792
71MP0002184_abnormal_innervation0.85759584
72MP0005385_cardiovascular_system_phenoty0.85337667
73MP0001544_abnormal_cardiovascular_syste0.85337667
74MP0000733_abnormal_muscle_development0.82441299
75MP0001502_abnormal_circadian_rhythm0.81756463
76MP0003787_abnormal_imprinting0.79673009
77MP0001299_abnormal_eye_distance/0.78439301
78MP0000566_synostosis0.77507923
79MP0005646_abnormal_pituitary_gland0.77019287
80MP0006138_congestive_heart_failure0.76807313
81MP0001984_abnormal_olfaction0.76765173
82MP0005423_abnormal_somatic_nervous0.74981966
83MP0010630_abnormal_cardiac_muscle0.74943436
84MP0002557_abnormal_social/conspecific_i0.74624232
85MP0009672_abnormal_birth_weight0.72694461
86MP0002736_abnormal_nociception_after0.72691947
87MP0002234_abnormal_pharynx_morphology0.70792633
88MP0003195_calcinosis0.70049418
89MP0003123_paternal_imprinting0.69386468
90MP0002229_neurodegeneration0.68438589
91MP0005386_behavior/neurological_phenoty0.67758163
92MP0004924_abnormal_behavior0.67758163
93MP0002882_abnormal_neuron_morphology0.61010630
94MP0002735_abnormal_chemical_nociception0.59983493
95MP0002078_abnormal_glucose_homeostasis0.59710035
96MP0005375_adipose_tissue_phenotype0.58117084
97MP0002971_abnormal_brown_adipose0.57858002
98MP0005670_abnormal_white_adipose0.57789547
99MP0002752_abnormal_somatic_nervous0.57500460
100MP0004134_abnormal_chest_morphology0.57450428
101MP0000372_irregular_coat_pigmentation0.56757532
102MP0002638_abnormal_pupillary_reflex0.56379709
103MP0005253_abnormal_eye_physiology0.56303859
104MP0005666_abnormal_adipose_tissue0.55921332
105MP0004147_increased_porphyrin_level0.55766003
106MP0002909_abnormal_adrenal_gland0.55761322
107MP0003950_abnormal_plasma_membrane0.55688779
108MP0010030_abnormal_orbit_morphology0.54862848
109MP0000534_abnormal_ureter_morphology0.54341588
110MP0001346_abnormal_lacrimal_gland0.53981790
111MP0005535_abnormal_body_temperature0.53534242
112MP0009697_abnormal_copulation0.53439223
113MP0005187_abnormal_penis_morphology0.53193165
114MP0000955_abnormal_spinal_cord0.52587394
115MP0001963_abnormal_hearing_physiology0.51619923
116MP0003959_abnormal_lean_body0.49948862
117MP0004811_abnormal_neuron_physiology0.49813421
118MP0005376_homeostasis/metabolism_phenot0.48057052
119MP0003718_maternal_effect0.44431394
120MP0000003_abnormal_adipose_tissue0.43898432
121MP0000230_abnormal_systemic_arterial0.41565700
122MP0008789_abnormal_olfactory_epithelium0.41549099
123MP0000266_abnormal_heart_morphology0.40063273
124MP0002876_abnormal_thyroid_physiology0.38837597
125MP0003828_pulmonary_edema0.38381493
126MP0010368_abnormal_lymphatic_system0.37381090
127MP0001661_extended_life_span0.37170536
128MP0005319_abnormal_enzyme/_coenzyme0.36846023
129MP0002138_abnormal_hepatobiliary_system0.36461753
130MP0002168_other_aberrant_phenotype0.36229440
131MP0000343_altered_response_to0.35481185
132MP0003633_abnormal_nervous_system0.34718236
133MP0006276_abnormal_autonomic_nervous0.32569562
134MP0004185_abnormal_adipocyte_glucose0.32011511
135MP0009764_decreased_sensitivity_to0.30935297
136MP0005166_decreased_susceptibility_to0.30565329
137MP0008877_abnormal_DNA_methylation0.30537827
138MP0004381_abnormal_hair_follicle0.29254945

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced muscle cramps (HP:0003710)9.10306177
2Exercise-induced myalgia (HP:0003738)8.60759533
3Muscle fiber inclusion bodies (HP:0100299)7.66395768
4Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)7.29954763
5Nemaline bodies (HP:0003798)6.84495046
6Muscle hypertrophy of the lower extremities (HP:0008968)5.97179988
7Myoglobinuria (HP:0002913)5.71431000
8Type 1 muscle fiber predominance (HP:0003803)5.50150214
9Myopathic facies (HP:0002058)5.48346638
10Distal arthrogryposis (HP:0005684)5.42161079
11Calf muscle hypertrophy (HP:0008981)5.05660858
12Round ear (HP:0100830)4.88988558
13Ulnar deviation of the wrist (HP:0003049)4.67570440
14Muscle stiffness (HP:0003552)4.60101043
15Rhabdomyolysis (HP:0003201)4.52522689
16Absent phalangeal crease (HP:0006109)4.13556875
17Centrally nucleated skeletal muscle fibers (HP:0003687)4.13401286
18Difficulty running (HP:0009046)3.94083638
19Hyporeflexia of lower limbs (HP:0002600)3.90384370
20Focal motor seizures (HP:0011153)3.90002229
21Myotonia (HP:0002486)3.86060264
22EMG: myopathic abnormalities (HP:0003458)3.84440887
23Muscle fiber splitting (HP:0003555)3.67686875
24Calcaneovalgus deformity (HP:0001848)3.65984211
25Abnormal finger flexion creases (HP:0006143)3.44850918
26Abnormality of the calf musculature (HP:0001430)3.39122749
27Congenital stationary night blindness (HP:0007642)3.35044350
28Febrile seizures (HP:0002373)3.29817204
29Deformed tarsal bones (HP:0008119)3.25351351
30Atonic seizures (HP:0010819)3.11140863
31Abnormal mitochondria in muscle tissue (HP:0008316)3.06756129
32Acute necrotizing encephalopathy (HP:0006965)2.89230190
33Bundle branch block (HP:0011710)2.87768320
34Shoulder girdle muscle weakness (HP:0003547)2.79435679
35Increased connective tissue (HP:0009025)2.77431102
36Scapular winging (HP:0003691)2.77125759
37Neuroendocrine neoplasm (HP:0100634)2.75134871
38Absence seizures (HP:0002121)2.72383619
39Abnormality of skeletal muscle fiber size (HP:0012084)2.70730496
40Weak cry (HP:0001612)2.69342449
41Rimmed vacuoles (HP:0003805)2.67041161
42Bulbar palsy (HP:0001283)2.65766249
43Cholecystitis (HP:0001082)2.65079655
44Abnormal gallbladder physiology (HP:0012438)2.65079655
45Central scotoma (HP:0000603)2.61822335
46Pheochromocytoma (HP:0002666)2.60451900
47Neck muscle weakness (HP:0000467)2.59690925
48Malignant hyperthermia (HP:0002047)2.58241807
49Areflexia of lower limbs (HP:0002522)2.56629284
50Pelvic girdle muscle weakness (HP:0003749)2.55208055
51Popliteal pterygium (HP:0009756)2.51422073
52Increased variability in muscle fiber diameter (HP:0003557)2.51313180
53Hyperkalemia (HP:0002153)2.49979612
54Abnormality of the hip-girdle musculature (HP:0001445)2.47878287
55Abnormality of the musculature of the pelvis (HP:0001469)2.47878287
56Abnormality of the left ventricular outflow tract (HP:0011103)2.46346270
57Subaortic stenosis (HP:0001682)2.46346270
58Progressive macrocephaly (HP:0004481)2.44562771
59Exercise intolerance (HP:0003546)2.39673298
60Gowers sign (HP:0003391)2.39254500
61Hip contracture (HP:0003273)2.38450425
62Cholelithiasis (HP:0001081)2.35157856
63Acute encephalopathy (HP:0006846)2.31384617
64Sudden death (HP:0001699)2.31227721
65Generalized tonic-clonic seizures (HP:0002069)2.30662086
66Progressive muscle weakness (HP:0003323)2.29546593
67Oligomenorrhea (HP:0000876)2.27921640
68Dilated cardiomyopathy (HP:0001644)2.27456114
69Epileptic encephalopathy (HP:0200134)2.27184418
70Hepatocellular necrosis (HP:0001404)2.26781605
71Mitochondrial inheritance (HP:0001427)2.26375431
72Mildly elevated creatine phosphokinase (HP:0008180)2.26096851
73Abnormality of the shoulder girdle musculature (HP:0001435)2.25586828
74Distal lower limb muscle weakness (HP:0009053)2.24684271
75Limb-girdle muscle atrophy (HP:0003797)2.22974909
76Asymmetric septal hypertrophy (HP:0001670)2.22558162
77Spinal rigidity (HP:0003306)2.15798706
78Type 2 muscle fiber atrophy (HP:0003554)2.12353465
79EMG: neuropathic changes (HP:0003445)2.11737933
80Abnormal gallbladder morphology (HP:0012437)2.10709513
81Heart block (HP:0012722)2.10443175
82Slender build (HP:0001533)2.06494983
83Paralysis (HP:0003470)2.06221945
84Visual hallucinations (HP:0002367)2.04677271
85Hepatic necrosis (HP:0002605)2.03992003
86Nonprogressive disorder (HP:0003680)2.03715807
87Dialeptic seizures (HP:0011146)2.03635882
88Gout (HP:0001997)2.03386421
89Difficulty climbing stairs (HP:0003551)2.02894523
90Frequent falls (HP:0002359)2.00924933
91Increased CSF lactate (HP:0002490)1.99396085
92Prolonged QT interval (HP:0001657)1.98024887
93Increased purine levels (HP:0004368)1.97731976
94Hyperuricemia (HP:0002149)1.97731976
95Abnormality of the calcaneus (HP:0008364)1.96192223
96Metatarsus adductus (HP:0001840)1.95202307
97Increased serum pyruvate (HP:0003542)1.93349294
98Abnormality of glycolysis (HP:0004366)1.93349294
99Hemiparesis (HP:0001269)1.93347255
100Facial diplegia (HP:0001349)1.92767809
101Lipoatrophy (HP:0100578)1.92408462
102Abnormal atrioventricular conduction (HP:0005150)1.91056869
103Abnormality of the foot musculature (HP:0001436)1.90319384
104Muscle fiber atrophy (HP:0100295)1.89296262
105Respiratory insufficiency due to muscle weakness (HP:0002747)1.85838053
106Distal lower limb amyotrophy (HP:0008944)1.83979467
107Abnormality of placental membranes (HP:0011409)1.80119604
108Amniotic constriction ring (HP:0009775)1.80119604
109Foot dorsiflexor weakness (HP:0009027)1.80110380
110Hypoplastic ischia (HP:0003175)1.76974661
111Palpitations (HP:0001962)1.75854171
112Fetal akinesia sequence (HP:0001989)1.75752715
113Waddling gait (HP:0002515)1.75064647
114Proximal amyotrophy (HP:0007126)1.74416854
115Limb-girdle muscle weakness (HP:0003325)1.74161179
116Fatigable weakness (HP:0003473)1.72014279
117Abnormality of the neuromuscular junction (HP:0003398)1.72014279
118Optic disc pallor (HP:0000543)1.70317569
119Difficulty walking (HP:0002355)1.69286030
120Ragged-red muscle fibers (HP:0003200)1.67727060
121Muscular dystrophy (HP:0003560)1.67714588
122Ventricular tachycardia (HP:0004756)1.67652750
123Left ventricular hypertrophy (HP:0001712)1.67289628
124Hypokalemia (HP:0002900)1.64136930
125Abnormality of potassium homeostasis (HP:0011042)1.64065551
126Generalized muscle weakness (HP:0003324)1.63483254
127Scotoma (HP:0000575)1.62686584
128Ulnar deviation of finger (HP:0009465)1.62055296
129Neoplasm of the peripheral nervous system (HP:0100007)1.61866914
130Long clavicles (HP:0000890)1.60859776
131Myokymia (HP:0002411)1.60554922
132Focal seizures (HP:0007359)1.59955661
133Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.57373463
134Steppage gait (HP:0003376)1.54181484
135Limited hip movement (HP:0008800)1.51876964
136Aplasia of the musculature (HP:0100854)1.45538606
137Ulnar deviation of the hand or of fingers of the hand (HP:0001193)1.44720544
138Tarsal synostosis (HP:0008368)1.44361359
139Ventricular arrhythmia (HP:0004308)1.36498776
140Easy fatigability (HP:0003388)1.33381175

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN6.32109653
2PHKG15.36097812
3PHKG25.36097812
4TTN4.21594729
5LATS14.20042581
6NME14.06877979
7NEK13.96984881
8MAP3K72.37450481
9PINK12.34453057
10PDK32.32842748
11PDK42.32842748
12PIK3CG2.27118678
13MAP2K42.03924252
14MAP2K31.93205221
15MOS1.75987905
16CDK81.70004449
17INSRR1.69536444
18MAP3K41.61816137
19MAPKAPK31.53167568
20PIK3CA1.52388073
21NTRK31.48206148
22RIPK11.44689466
23PDK21.27448346
24TAOK21.26903211
25MUSK1.18797202
26MAPK121.13538435
27MAP3K91.08533006
28MAP2K71.05147422
29MAP2K61.03607376
30PAK61.02342490
31CASK1.01952158
32MYLK0.97679459
33PRKAA10.96540926
34EEF2K0.94808635
35TIE10.94083739
36LATS20.93141054
37MINK10.93036558
38DMPK0.89738283
39MARK30.89075693
40PLK20.88161015
41STK30.86322342
42IRAK20.85352593
43CCNB10.83594870
44ERBB40.81586560
45FRK0.81077174
46LIMK10.80631335
47PRKAA20.77659049
48GRK70.76010468
49PRKCG0.73594155
50MARK10.73068408
51TNIK0.73025872
52ACVR1B0.71996379
53PRPF4B0.71929761
54AKT20.70747426
55CAMK40.70250382
56CAMK2G0.67787754
57AKT30.66965805
58NEK90.61497289
59STK380.61405370
60MAP3K10.61211475
61MAP3K120.60978082
62ZAK0.58716310
63PDPK10.58124024
64TGFBR20.56967441
65PAK30.56207653
66MAPK70.54445675
67NEK60.53898260
68ERBB30.53526809
69PRKACB0.50656523
70RPS6KA30.50627404
71PRKACA0.50566016
72ICK0.50478464
73CAMK2A0.49846813
74KSR10.49313042
75DYRK1A0.48582172
76STK240.48109163
77SGK10.47834711
78NLK0.47547295
79CDK50.47494528
80MAPK110.47462162
81CDC42BPA0.46734365
82CAMK2D0.46552626
83TRIB30.45198460
84BCKDK0.44895679
85PKN20.44794179
86EIF2AK30.44681324
87CAMK2B0.43610355
88EPHA40.41977137
89ARAF0.40892886
90MAP2K10.40874264
91PDK10.38048556
92IRAK30.37976741
93CDK40.37964533
94SGK2230.37946941
95SGK4940.37946941
96PTK60.36615418
97CDK140.36505828
98PRKG10.36391530
99STK38L0.36009070
100NTRK20.35956186
101FGFR10.34154808
102TNK20.33936519
103CDK150.33527047
104PRKCH0.33257578
105MAPK40.32314673
106BRAF0.32030170
107CDK180.31773396
108ROCK10.31528008
109PTK2B0.31198387
110GRK50.31129964
111MELK0.31054510
112CAMK10.30964868
113SGK20.29354655
114SGK30.29065383
115DDR20.28980424
116PRKD10.28116731
117NUAK10.27973063
118MAPK130.27720321
119ADRBK20.27660571
120PKN10.27099372
121DAPK20.26190189
122IRAK10.25270737
123PRKD30.25152341
124CDK11A0.24674514
125PRKCA0.24449178
126MAP2K20.23291017
127MAP3K130.23185921
128BMPR1B0.22605965
129PRKCB0.22579061
130CAMKK20.22483324
131PRKCE0.22355564
132CDK30.22343043
133TRPM70.20925935
134RPS6KB10.20838606
135CDK190.20605806
136PRKACG0.19752907
137KSR20.19590229
138NEK20.19261242
139MAPK100.18093116
140MAPKAPK50.17372306
141TGFBR10.17212347
142CSNK1D0.14628747
143PAK10.13586159
144DYRK1B0.13285826

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.04119770
2Cardiac muscle contraction_Homo sapiens_hsa042603.52346791
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.99489908
42-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.90667967
5Oxidative phosphorylation_Homo sapiens_hsa001902.65071139
6Nicotine addiction_Homo sapiens_hsa050332.56685579
7Synaptic vesicle cycle_Homo sapiens_hsa047212.50621539
8Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.49682807
9Parkinsons disease_Homo sapiens_hsa050122.31288039
10Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.20396712
11Dilated cardiomyopathy_Homo sapiens_hsa054142.12839724
12GABAergic synapse_Homo sapiens_hsa047272.09456124
13Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.07617111
14Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.02211506
15Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.97645599
16Circadian rhythm_Homo sapiens_hsa047101.93374251
17Carbon metabolism_Homo sapiens_hsa012001.93358383
18Alzheimers disease_Homo sapiens_hsa050101.90122351
19Oxytocin signaling pathway_Homo sapiens_hsa049211.85565334
20Pyruvate metabolism_Homo sapiens_hsa006201.80593507
21Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.78722658
22Collecting duct acid secretion_Homo sapiens_hsa049661.75861093
23Biosynthesis of amino acids_Homo sapiens_hsa012301.70588709
24Circadian entrainment_Homo sapiens_hsa047131.69921615
25Glucagon signaling pathway_Homo sapiens_hsa049221.69627672
26Fructose and mannose metabolism_Homo sapiens_hsa000511.66677043
27Calcium signaling pathway_Homo sapiens_hsa040201.63521300
28Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.62294953
29Morphine addiction_Homo sapiens_hsa050321.62081682
30Insulin secretion_Homo sapiens_hsa049111.43355445
31cGMP-PKG signaling pathway_Homo sapiens_hsa040221.39294142
32Nitrogen metabolism_Homo sapiens_hsa009101.39206630
33Olfactory transduction_Homo sapiens_hsa047401.38991182
34Huntingtons disease_Homo sapiens_hsa050161.34870207
35Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.30890473
36Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.30432265
37Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.27223770
38Dopaminergic synapse_Homo sapiens_hsa047281.22645317
39Galactose metabolism_Homo sapiens_hsa000521.21730276
40Insulin signaling pathway_Homo sapiens_hsa049101.21454744
41Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.21367309
42Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.17010731
43Starch and sucrose metabolism_Homo sapiens_hsa005001.16204683
44Ovarian steroidogenesis_Homo sapiens_hsa049131.14503853
45Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.06834441
46Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.03593904
47Long-term depression_Homo sapiens_hsa047301.02512201
48Propanoate metabolism_Homo sapiens_hsa006401.01779810
49Type II diabetes mellitus_Homo sapiens_hsa049300.99515074
50Vibrio cholerae infection_Homo sapiens_hsa051100.98623602
51Long-term potentiation_Homo sapiens_hsa047200.97325608
52Renin secretion_Homo sapiens_hsa049240.95885765
53Glutamatergic synapse_Homo sapiens_hsa047240.95735523
54Dorso-ventral axis formation_Homo sapiens_hsa043200.93833781
55AMPK signaling pathway_Homo sapiens_hsa041520.93556499
56Serotonergic synapse_Homo sapiens_hsa047260.91437174
57Gastric acid secretion_Homo sapiens_hsa049710.90976062
58Tryptophan metabolism_Homo sapiens_hsa003800.89643305
59Vascular smooth muscle contraction_Homo sapiens_hsa042700.89568367
60Amphetamine addiction_Homo sapiens_hsa050310.86694851
61Aldosterone synthesis and secretion_Homo sapiens_hsa049250.86641366
62Salivary secretion_Homo sapiens_hsa049700.85738390
63Phenylalanine metabolism_Homo sapiens_hsa003600.84173695
64Insulin resistance_Homo sapiens_hsa049310.80599815
65Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.80520349
66Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.79616543
67Cholinergic synapse_Homo sapiens_hsa047250.78954257
68Cysteine and methionine metabolism_Homo sapiens_hsa002700.77484283
69Central carbon metabolism in cancer_Homo sapiens_hsa052300.77227381
70Pentose phosphate pathway_Homo sapiens_hsa000300.77099757
71Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.73898360
72Folate biosynthesis_Homo sapiens_hsa007900.72340716
73GnRH signaling pathway_Homo sapiens_hsa049120.71616614
74Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.70155989
75Basal transcription factors_Homo sapiens_hsa030220.68959606
76beta-Alanine metabolism_Homo sapiens_hsa004100.68545047
77Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.66419053
78Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.65606405
79Taste transduction_Homo sapiens_hsa047420.64217038
80Phototransduction_Homo sapiens_hsa047440.62881520
81Butanoate metabolism_Homo sapiens_hsa006500.61472764
82Arginine and proline metabolism_Homo sapiens_hsa003300.60869328
83Adipocytokine signaling pathway_Homo sapiens_hsa049200.58961768
84Lysine degradation_Homo sapiens_hsa003100.56178706
85Sulfur metabolism_Homo sapiens_hsa009200.55339060
86Arginine biosynthesis_Homo sapiens_hsa002200.55284379
87Tight junction_Homo sapiens_hsa045300.54186487
88Longevity regulating pathway - mammal_Homo sapiens_hsa042110.50808135
89MAPK signaling pathway_Homo sapiens_hsa040100.50680169
90Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.48769798
91Histidine metabolism_Homo sapiens_hsa003400.47306290
92HIF-1 signaling pathway_Homo sapiens_hsa040660.45143865
93Fatty acid metabolism_Homo sapiens_hsa012120.44161138
94Fatty acid elongation_Homo sapiens_hsa000620.43503131
95PPAR signaling pathway_Homo sapiens_hsa033200.42009953
96Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.41024313
97Carbohydrate digestion and absorption_Homo sapiens_hsa049730.39486200
98Amoebiasis_Homo sapiens_hsa051460.38450254
99Oocyte meiosis_Homo sapiens_hsa041140.37602195
100Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.37020874
101Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.36895061
102Thyroid hormone synthesis_Homo sapiens_hsa049180.36144191
103Mineral absorption_Homo sapiens_hsa049780.35903834
104cAMP signaling pathway_Homo sapiens_hsa040240.35529571
105ABC transporters_Homo sapiens_hsa020100.34653741
106Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.33283486
107Focal adhesion_Homo sapiens_hsa045100.32867090
108Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.32537163
109FoxO signaling pathway_Homo sapiens_hsa040680.31885370
110Phosphatidylinositol signaling system_Homo sapiens_hsa040700.31396123
111Gap junction_Homo sapiens_hsa045400.31190034
112Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.31155379
113Pancreatic secretion_Homo sapiens_hsa049720.27609142
114mTOR signaling pathway_Homo sapiens_hsa041500.25411182
115Tyrosine metabolism_Homo sapiens_hsa003500.25211239
116Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.24334215
117Purine metabolism_Homo sapiens_hsa002300.23559666
118Melanogenesis_Homo sapiens_hsa049160.22400678
119Fatty acid biosynthesis_Homo sapiens_hsa000610.21300749
120Metabolic pathways_Homo sapiens_hsa011000.19721423
121Rheumatoid arthritis_Homo sapiens_hsa053230.19552961
122Regulation of autophagy_Homo sapiens_hsa041400.19524319
123Inositol phosphate metabolism_Homo sapiens_hsa005620.19259047
124Fatty acid degradation_Homo sapiens_hsa000710.18823974

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