LRRC3B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a tumor suppressor, with lowered expression levels found in gastric, renal, colorectal, lung, and breast cancer tissues. The promoter of this gene is frequently hypermethylated in these cancer tissues, although the hypermethylation does not appear to be the cause of the reduced expression of this gene. Several transcript variants encoding the same protein have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sensory perception of smell (GO:0007608)7.13391290
2postsynaptic membrane organization (GO:0001941)6.20859802
3mechanosensory behavior (GO:0007638)5.18474591
4synaptic vesicle exocytosis (GO:0016079)5.09017242
5regulation of short-term neuronal synaptic plasticity (GO:0048172)4.90780613
6neuron cell-cell adhesion (GO:0007158)4.89367058
7glutamate secretion (GO:0014047)4.58816784
8regulation of cilium movement (GO:0003352)4.51857510
9pyrimidine nucleobase catabolic process (GO:0006208)4.50875670
10C4-dicarboxylate transport (GO:0015740)4.45164583
11otic vesicle formation (GO:0030916)4.44773144
12regulation of synapse structural plasticity (GO:0051823)4.38981110
13cerebral cortex radially oriented cell migration (GO:0021799)4.36386698
14response to auditory stimulus (GO:0010996)4.34800797
15vocalization behavior (GO:0071625)4.32323468
16positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.27255645
17behavioral response to cocaine (GO:0048148)4.19253094
18sensory perception of chemical stimulus (GO:0007606)4.09382908
19positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.03941353
20negative regulation of cytosolic calcium ion concentration (GO:0051481)4.01659621
21presynaptic membrane organization (GO:0097090)3.94517891
22regulation of synaptic vesicle exocytosis (GO:2000300)3.87797077
23neurotransmitter secretion (GO:0007269)3.81172568
24positive regulation of dendritic spine morphogenesis (GO:0061003)3.80969061
25detection of calcium ion (GO:0005513)3.78265010
26short-term memory (GO:0007614)3.76746622
27activation of protein kinase A activity (GO:0034199)3.75683448
28negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.74901935
29L-amino acid import (GO:0043092)3.71648932
30presynaptic membrane assembly (GO:0097105)3.68939771
31regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.66817952
32synaptic vesicle maturation (GO:0016188)3.62585431
33epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.61003071
34membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.60535764
35nucleobase catabolic process (GO:0046113)3.60232868
36regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.59069309
37striatum development (GO:0021756)3.57386718
38regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.57348119
39cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.56717258
40dopamine biosynthetic process (GO:0042416)3.53788103
41prepulse inhibition (GO:0060134)3.53718552
42dopamine transport (GO:0015872)3.52904931
43regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.52467610
44positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.51915813
45positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.50771689
46calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.50664648
47synaptic vesicle endocytosis (GO:0048488)3.49567667
48central nervous system projection neuron axonogenesis (GO:0021952)3.49227908
49regulation of protein kinase A signaling (GO:0010738)3.47946404
50regulation of voltage-gated calcium channel activity (GO:1901385)3.47817602
51regulation of glutamate receptor signaling pathway (GO:1900449)3.46887205
52regulation of long-term neuronal synaptic plasticity (GO:0048169)3.45294343
53regulation of synaptic vesicle transport (GO:1902803)3.44332927
54synaptic transmission, dopaminergic (GO:0001963)3.42122949
55axonal fasciculation (GO:0007413)3.41095589
56protein localization to synapse (GO:0035418)3.40399482
57calcium-mediated signaling using intracellular calcium source (GO:0035584)3.39931641
58neuron-neuron synaptic transmission (GO:0007270)3.39818364
59glutamate receptor signaling pathway (GO:0007215)3.39092759
60positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.34822803
61ionotropic glutamate receptor signaling pathway (GO:0035235)3.32537870
62mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.32074684
63negative regulation of synaptic transmission, GABAergic (GO:0032229)3.31008681
64regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.29995777
65regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.29995777
66mating behavior (GO:0007617)3.26269533
67regulation of cell communication by electrical coupling (GO:0010649)3.24796656
68neurotransmitter transport (GO:0006836)3.24600423
69response to histamine (GO:0034776)3.22765021
70regulation of neurotransmitter levels (GO:0001505)3.22656875
71G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.20909084
72transmission of nerve impulse (GO:0019226)3.19975722
73neuron recognition (GO:0008038)3.19749593
74regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.18605573
75positive regulation of synapse maturation (GO:0090129)3.17785859
76regulation of microtubule-based movement (GO:0060632)3.17732281
77negative regulation of microtubule polymerization (GO:0031115)3.16679173
78gamma-aminobutyric acid transport (GO:0015812)3.16327624
79cell communication by electrical coupling (GO:0010644)3.15366450
80neuronal action potential propagation (GO:0019227)3.14246306
81cellular potassium ion homeostasis (GO:0030007)3.13737773
82gamma-aminobutyric acid signaling pathway (GO:0007214)3.13473209
83layer formation in cerebral cortex (GO:0021819)3.12169002
84regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.11781422
85positive regulation of synapse assembly (GO:0051965)3.11698416
86neurotransmitter biosynthetic process (GO:0042136)3.11685672
87nonmotile primary cilium assembly (GO:0035058)3.10296274
88exploration behavior (GO:0035640)3.10074354
89limb bud formation (GO:0060174)3.09869422
90neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.08965946
91auditory behavior (GO:0031223)3.07848307
92regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.07695419
93synaptic vesicle docking involved in exocytosis (GO:0016081)3.07313791
94cerebellar Purkinje cell differentiation (GO:0021702)3.06809682
95locomotory exploration behavior (GO:0035641)3.06712137
96retinal ganglion cell axon guidance (GO:0031290)3.05973898
97mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.04279757
98catecholamine transport (GO:0051937)3.02665792
99membrane depolarization during action potential (GO:0086010)3.02446657
100regulation of neuronal synaptic plasticity (GO:0048168)3.02055581
101positive regulation of neurotransmitter transport (GO:0051590)3.02028144
102response to cocaine (GO:0042220)3.01204512
103cell communication involved in cardiac conduction (GO:0086065)2.99314267
104positive regulation of potassium ion transmembrane transport (GO:1901381)2.99230552
105synaptic transmission, glutamatergic (GO:0035249)2.98430758
106neurotransmitter uptake (GO:0001504)2.98411396
107regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.98402694
108protein localization to cilium (GO:0061512)2.98364430
109positive regulation of dendritic spine development (GO:0060999)2.97974685
110sodium ion export (GO:0071436)2.96698198
111negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.95291278
112positive regulation of membrane potential (GO:0045838)2.94821303
113negative regulation of astrocyte differentiation (GO:0048712)2.94139131
114central nervous system neuron axonogenesis (GO:0021955)2.93827110
115behavioral fear response (GO:0001662)2.93654074
116behavioral defense response (GO:0002209)2.93654074
117neurotransmitter-gated ion channel clustering (GO:0072578)2.93345223
118regulation of dendritic spine morphogenesis (GO:0061001)2.93204227
119behavioral response to ethanol (GO:0048149)2.92868370
120regulation of membrane repolarization (GO:0060306)2.92757866
121regulation of dopamine secretion (GO:0014059)2.91650730
122protein polyglutamylation (GO:0018095)2.90718977
123regulation of synapse maturation (GO:0090128)2.90341607
124regulation of acyl-CoA biosynthetic process (GO:0050812)2.90076820
125fear response (GO:0042596)2.89729016
126regulation of heart rate by cardiac conduction (GO:0086091)2.89171327
127regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.89098754
128ATP synthesis coupled proton transport (GO:0015986)2.87712052
129energy coupled proton transport, down electrochemical gradient (GO:0015985)2.87712052
130regulation of excitatory postsynaptic membrane potential (GO:0060079)2.87627853
131amino acid import (GO:0043090)2.85572418
132respiratory electron transport chain (GO:0022904)2.85027466
133regulation of neurotransmitter transport (GO:0051588)2.83910652
134negative regulation of cation channel activity (GO:2001258)2.83578441
135glycosphingolipid biosynthetic process (GO:0006688)2.83325705
136regulation of neurotransmitter secretion (GO:0046928)2.83196619
137synapse assembly (GO:0007416)2.83159357
138regulation of synaptic transmission, glutamatergic (GO:0051966)2.82874492
139regulation of timing of cell differentiation (GO:0048505)2.80786020
140oligodendrocyte differentiation (GO:0048709)2.78207760
141startle response (GO:0001964)2.77200365
142regulation of cardiac muscle cell contraction (GO:0086004)2.71323275
143synapse organization (GO:0050808)2.70789435
144regulation of development, heterochronic (GO:0040034)2.69481107
145epithelial cilium movement (GO:0003351)2.69017667
146cerebral cortex cell migration (GO:0021795)2.66295082
147regulation of dendritic spine development (GO:0060998)2.64475428
148microtubule depolymerization (GO:0007019)2.64147348
149microtubule polymerization or depolymerization (GO:0031109)2.63668292
150dendritic spine morphogenesis (GO:0060997)2.63663271
151neuromuscular synaptic transmission (GO:0007274)2.62157089
152regulation of respiratory system process (GO:0044065)2.60832085
153hindbrain development (GO:0030902)2.60402679
154proline transport (GO:0015824)2.59582144
155regulation of postsynaptic membrane potential (GO:0060078)2.58092744
156axonogenesis (GO:0007409)2.57955100
157olfactory bulb development (GO:0021772)2.57620829
158retinal cone cell development (GO:0046549)2.56989227
159synaptic vesicle transport (GO:0048489)2.56620914
160establishment of synaptic vesicle localization (GO:0097480)2.56620914
161negative regulation of transcription regulatory region DNA binding (GO:2000678)2.54183001
162dendrite morphogenesis (GO:0048813)2.53545161
163behavioral response to nicotine (GO:0035095)2.53304853
164membrane depolarization (GO:0051899)2.52344025
165positive regulation of synaptic transmission, GABAergic (GO:0032230)2.52167030
166cochlea development (GO:0090102)2.49250901

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.00476169
2GBX2_23144817_ChIP-Seq_PC3_Human4.10563108
3* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.94501548
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.93390022
5* TAF15_26573619_Chip-Seq_HEK293_Human2.86407654
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.76528496
7SALL1_21062744_ChIP-ChIP_HESCs_Human2.61966179
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.56486862
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.56486862
10* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.50225799
11REST_21632747_ChIP-Seq_MESCs_Mouse2.42566749
12DROSHA_22980978_ChIP-Seq_HELA_Human2.38926265
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.35253547
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.33693399
15* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.32685027
16JARID2_20075857_ChIP-Seq_MESCs_Mouse2.31681096
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.30472865
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.29323476
19* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.28930492
20RBPJ_22232070_ChIP-Seq_NCS_Mouse2.19063430
21NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.08604478
22CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.07826975
23* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.01163430
24EZH2_27294783_Chip-Seq_ESCs_Mouse1.98012279
25GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.96696056
26ZFP57_27257070_Chip-Seq_ESCs_Mouse1.94200371
27GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.92651367
28TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.91670146
29REST_18959480_ChIP-ChIP_MESCs_Mouse1.90403218
30RARB_27405468_Chip-Seq_BRAIN_Mouse1.89921092
31CTBP1_25329375_ChIP-Seq_LNCAP_Human1.89373725
32ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.89087903
33RNF2_27304074_Chip-Seq_ESCs_Mouse1.87479991
34* SMAD4_21799915_ChIP-Seq_A2780_Human1.87360084
35CTBP2_25329375_ChIP-Seq_LNCAP_Human1.80497553
36P300_19829295_ChIP-Seq_ESCs_Human1.76377489
37CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.74428886
38BMI1_23680149_ChIP-Seq_NPCS_Mouse1.69301800
39EWS_26573619_Chip-Seq_HEK293_Human1.66647100
40MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.64751485
41ZNF274_21170338_ChIP-Seq_K562_Hela1.59081787
42* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.58780625
43IKZF1_21737484_ChIP-ChIP_HCT116_Human1.58545239
44PIAS1_25552417_ChIP-Seq_VCAP_Human1.58073294
45VDR_22108803_ChIP-Seq_LS180_Human1.56640039
46NR3C1_23031785_ChIP-Seq_PC12_Mouse1.54016465
47SMAD3_21741376_ChIP-Seq_EPCs_Human1.50823586
48* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.48440731
49SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.42530891
50POU3F2_20337985_ChIP-ChIP_501MEL_Human1.40952123
51PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.39875782
52SOX2_21211035_ChIP-Seq_LN229_Gbm1.37503391
53HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.37373862
54OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37133437
55SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37028325
56SOX9_26525672_Chip-Seq_HEART_Mouse1.36668225
57AR_21572438_ChIP-Seq_LNCaP_Human1.36506287
58SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.36105527
59KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.34423705
60RNF2_27304074_Chip-Seq_NSC_Mouse1.33579484
61TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.31734615
62TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.30813656
63MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.29007916
64PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.28794814
65EP300_21415370_ChIP-Seq_HL-1_Mouse1.28409905
66* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27941766
67CBX2_27304074_Chip-Seq_ESCs_Mouse1.27806919
68UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.26663342
69NANOG_18555785_Chip-Seq_ESCs_Mouse1.26085471
70CDX2_19796622_ChIP-Seq_MESCs_Mouse1.25542671
71RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.24609204
72POU5F1_16153702_ChIP-ChIP_HESCs_Human1.24357855
73BCAT_22108803_ChIP-Seq_LS180_Human1.23409431
74STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.22031878
75IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.21560415
76CBP_20019798_ChIP-Seq_JUKART_Human1.21560415
77IGF1R_20145208_ChIP-Seq_DFB_Human1.20768235
78* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.19876084
79STAT3_23295773_ChIP-Seq_U87_Human1.19331717
80SMAD_19615063_ChIP-ChIP_OVARY_Human1.19100729
81RING1B_27294783_Chip-Seq_ESCs_Mouse1.18141991
82AHR_22903824_ChIP-Seq_MCF-7_Human1.17972580
83ARNT_22903824_ChIP-Seq_MCF-7_Human1.17917647
84AR_25329375_ChIP-Seq_VCAP_Human1.17176006
85TP53_16413492_ChIP-PET_HCT116_Human1.14991702
86TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.14932738
87MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.14484005
88FUS_26573619_Chip-Seq_HEK293_Human1.13625213
89MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.13458434
90EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.12278981
91FLI1_21867929_ChIP-Seq_TH2_Mouse1.12223849
92POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.11979479
93TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11979479
94ERG_21242973_ChIP-ChIP_JURKAT_Human1.11269727
95ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.09642577
96* PRDM14_20953172_ChIP-Seq_ESCs_Human1.08440543
97* RUNX2_22187159_ChIP-Seq_PCA_Human1.08299619
98SUZ12_27294783_Chip-Seq_NPCs_Mouse1.08089963
99* TAL1_26923725_Chip-Seq_HPCs_Mouse1.07482700
100NR3C1_21868756_ChIP-Seq_MCF10A_Human1.05804807
101KDM2B_26808549_Chip-Seq_REH_Human1.05179315
102RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.05168678
103RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.05125017
104* ER_23166858_ChIP-Seq_MCF-7_Human1.04771049
105* AR_19668381_ChIP-Seq_PC3_Human1.04212430
106TCF4_23295773_ChIP-Seq_U87_Human1.04009687
107FLI1_27457419_Chip-Seq_LIVER_Mouse1.03604288
108TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.03433871
109BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.02215042
110GATA1_26923725_Chip-Seq_HPCs_Mouse1.01958656
111YAP1_20516196_ChIP-Seq_MESCs_Mouse0.97557698
112CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.97131381
113JUN_21703547_ChIP-Seq_K562_Human0.95239595
114FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.94709334
115SMAD4_21741376_ChIP-Seq_HESCs_Human0.94619167
116TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94123507
117EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.93058035
118WT1_25993318_ChIP-Seq_PODOCYTE_Human0.92571347
119ZNF217_24962896_ChIP-Seq_MCF-7_Human0.92145147
120SMAD4_21741376_ChIP-Seq_EPCs_Human0.90229979
121P53_22127205_ChIP-Seq_FIBROBLAST_Human0.88825715
122TP53_18474530_ChIP-ChIP_U2OS_Human0.88447852
123LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87238757
124* TCF4_22108803_ChIP-Seq_LS180_Human0.86004098
125GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.86001276
126* CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.85861895

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001984_abnormal_olfaction5.82877209
2MP0003880_abnormal_central_pattern4.57745677
3MP0004859_abnormal_synaptic_plasticity4.00896211
4MP0002822_catalepsy3.40080728
5MP0003635_abnormal_synaptic_transmissio3.34002819
6MP0009046_muscle_twitch2.95520000
7MP0006292_abnormal_olfactory_placode2.91274524
8MP0009745_abnormal_behavioral_response2.83032436
9MP0000566_synostosis2.81181418
10MP0002064_seizures2.69115481
11MP0002837_dystrophic_cardiac_calcinosis2.66410590
12MP0002063_abnormal_learning/memory/cond2.62521420
13MP0006276_abnormal_autonomic_nervous2.42196764
14MP0002272_abnormal_nervous_system2.38583835
15MP0004270_analgesia2.37050686
16MP0002572_abnormal_emotion/affect_behav2.36597672
17MP0001968_abnormal_touch/_nociception2.35661399
18MP0002734_abnormal_mechanical_nocicepti2.20706721
19MP0001529_abnormal_vocalization2.20678879
20MP0002184_abnormal_innervation2.15652112
21MP0001486_abnormal_startle_reflex2.14671261
22MP0002735_abnormal_chemical_nociception2.13497827
23MP0002653_abnormal_ependyma_morphology2.11240929
24MP0000751_myopathy2.10602789
25MP0000569_abnormal_digit_pigmentation2.07024753
26MP0004215_abnormal_myocardial_fiber2.03571253
27MP0001905_abnormal_dopamine_level2.03123673
28MP0002736_abnormal_nociception_after1.94965791
29MP0005248_abnormal_Harderian_gland1.91830008
30MP0001501_abnormal_sleep_pattern1.89462977
31MP0001188_hyperpigmentation1.88846360
32MP0009780_abnormal_chondrocyte_physiolo1.88516089
33MP0002909_abnormal_adrenal_gland1.86708978
34MP0002067_abnormal_sensory_capabilities1.83844042
35MP0005499_abnormal_olfactory_system1.83708433
36MP0005394_taste/olfaction_phenotype1.83708433
37MP0003646_muscle_fatigue1.82548217
38MP0005423_abnormal_somatic_nervous1.80864727
39MP0001970_abnormal_pain_threshold1.76889985
40MP0001440_abnormal_grooming_behavior1.76691484
41MP0002733_abnormal_thermal_nociception1.74681051
42MP0002234_abnormal_pharynx_morphology1.72620740
43MP0002557_abnormal_social/conspecific_i1.70353404
44MP0004924_abnormal_behavior1.65801949
45MP0005386_behavior/neurological_phenoty1.65801949
46MP0002332_abnormal_exercise_endurance1.60759723
47MP0003136_yellow_coat_color1.60217654
48MP0003122_maternal_imprinting1.59560303
49MP0004885_abnormal_endolymph1.57698742
50MP0006072_abnormal_retinal_apoptosis1.55003483
51MP0000631_abnormal_neuroendocrine_gland1.54549095
52MP0002233_abnormal_nose_morphology1.50849034
53MP0008789_abnormal_olfactory_epithelium1.48874464
54MP0004084_abnormal_cardiac_muscle1.47860128
55MP0005646_abnormal_pituitary_gland1.45211493
56MP0010030_abnormal_orbit_morphology1.42481913
57MP0005645_abnormal_hypothalamus_physiol1.41174374
58MP0002938_white_spotting1.39348739
59MP0004811_abnormal_neuron_physiology1.39280119
60MP0004145_abnormal_muscle_electrophysio1.39036242
61MP0008569_lethality_at_weaning1.37939032
62MP0000778_abnormal_nervous_system1.36577159
63MP0004036_abnormal_muscle_relaxation1.36146992
64MP0004484_altered_response_of1.31843740
65MP0000049_abnormal_middle_ear1.30187036
66MP0004085_abnormal_heartbeat1.30062314
67MP0004142_abnormal_muscle_tone1.29749000
68MP0001299_abnormal_eye_distance/1.27896553
69MP0002638_abnormal_pupillary_reflex1.24932781
70MP0005409_darkened_coat_color1.23887986
71MP0005253_abnormal_eye_physiology1.22916172
72MP0001293_anophthalmia1.21558057
73MP0003937_abnormal_limbs/digits/tail_de1.20136526
74MP0002882_abnormal_neuron_morphology1.19952457
75MP0004858_abnormal_nervous_system1.18488740
76MP0002066_abnormal_motor_capabilities/c1.17790350
77MP0003938_abnormal_ear_development1.15449081
78MP0003121_genomic_imprinting1.14308665
79MP0000955_abnormal_spinal_cord1.12689748
80MP0000026_abnormal_inner_ear1.12180342
81MP0003011_delayed_dark_adaptation1.11735282
82MP0000579_abnormal_nail_morphology1.10177451
83MP0003329_amyloid_beta_deposits1.07819677
84MP0002751_abnormal_autonomic_nervous1.06355415
85MP0001346_abnormal_lacrimal_gland1.05869768
86MP0003137_abnormal_impulse_conducting1.05237559
87MP0004130_abnormal_muscle_cell1.03276996
88MP0003633_abnormal_nervous_system1.02819996
89MP0005535_abnormal_body_temperature1.02652623
90MP0005330_cardiomyopathy1.01463664
91MP0002102_abnormal_ear_morphology1.00901949
92MP0003755_abnormal_palate_morphology0.99524313
93MP0001963_abnormal_hearing_physiology0.98871057
94MP0002249_abnormal_larynx_morphology0.97751892
95MP0003879_abnormal_hair_cell0.97597819
96MP0008874_decreased_physiological_sensi0.95049806
97MP0003861_abnormal_nervous_system0.94176788
98MP0005620_abnormal_muscle_contractility0.94009739
99MP0002972_abnormal_cardiac_muscle0.92889186
100MP0001177_atelectasis0.92765397
101MP0005391_vision/eye_phenotype0.90599337
102MP0002152_abnormal_brain_morphology0.89675836
103MP0004133_heterotaxia0.87081374
104MP0001502_abnormal_circadian_rhythm0.86872381
105MP0003567_abnormal_fetal_cardiomyocyte0.86767125
106MP0005187_abnormal_penis_morphology0.86211812
107MP0005195_abnormal_posterior_eye0.86170445
108MP0008775_abnormal_heart_ventricle0.85943887
109MP0002752_abnormal_somatic_nervous0.85217776
110MP0003631_nervous_system_phenotype0.84863651
111MP0004233_abnormal_muscle_weight0.84317912
112MP0002282_abnormal_trachea_morphology0.83448463
113MP0004510_myositis0.83365522
114MP0008872_abnormal_physiological_respon0.82817833
115MP0005551_abnormal_eye_electrophysiolog0.80042438
116MP0003787_abnormal_imprinting0.79841776
117MP0000747_muscle_weakness0.79256564
118MP0000534_abnormal_ureter_morphology0.78611370
119MP0001664_abnormal_digestion0.77777998
120MP0005171_absent_coat_pigmentation0.77435475
121MP0002229_neurodegeneration0.77058885
122MP0001485_abnormal_pinna_reflex0.76893635
123MP0000013_abnormal_adipose_tissue0.76363278
124MP0006138_congestive_heart_failure0.76235108
125MP0000428_abnormal_craniofacial_morphol0.76151967
126MP0003632_abnormal_nervous_system0.74296289
127MP0002697_abnormal_eye_size0.73976791
128MP0005623_abnormal_meninges_morphology0.72708937
129MP0006035_abnormal_mitochondrial_morpho0.72103099
130MP0002092_abnormal_eye_morphology0.71990693
131MP0001324_abnormal_eye_pigmentation0.71150664
132MP0002069_abnormal_eating/drinking_beha0.70231240
133MP0000749_muscle_degeneration0.68790052
134MP0004087_abnormal_muscle_fiber0.68477440
135MP0006036_abnormal_mitochondrial_physio0.67694402
136MP0010386_abnormal_urinary_bladder0.66041597
137MP0003634_abnormal_glial_cell0.63591458
138MP0004742_abnormal_vestibular_system0.60928595
139MP0002106_abnormal_muscle_physiology0.60706651
140MP0002876_abnormal_thyroid_physiology0.59174932
141MP0004043_abnormal_pH_regulation0.58629731
142MP0000372_irregular_coat_pigmentation0.57908066
143MP0002090_abnormal_vision0.56794264
144MP0005369_muscle_phenotype0.56124001

Predicted human phenotypes

RankGene SetZ-score
1Limb dystonia (HP:0002451)6.36673875
2Focal motor seizures (HP:0011153)5.43289553
3Myokymia (HP:0002411)4.97048967
4Retinal dysplasia (HP:0007973)4.76407410
5Atonic seizures (HP:0010819)4.72000852
6Focal seizures (HP:0007359)4.61282259
7Visual hallucinations (HP:0002367)4.51109070
8Pheochromocytoma (HP:0002666)4.16347323
9True hermaphroditism (HP:0010459)4.00555322
10Febrile seizures (HP:0002373)3.95261119
11Neuroendocrine neoplasm (HP:0100634)3.88723537
12Hemiparesis (HP:0001269)3.84921387
13Acute necrotizing encephalopathy (HP:0006965)3.80984768
14Absence seizures (HP:0002121)3.66007976
15Abnormal mitochondria in muscle tissue (HP:0008316)3.62091563
16Sudden death (HP:0001699)3.57244285
17Progressive macrocephaly (HP:0004481)3.46345834
18Syncope (HP:0001279)3.44228833
19Epileptic encephalopathy (HP:0200134)3.36896732
20Dialeptic seizures (HP:0011146)3.34523174
21Progressive cerebellar ataxia (HP:0002073)3.27722347
22Palpitations (HP:0001962)3.24555633
23Acute encephalopathy (HP:0006846)3.19350785
24Pancreatic fibrosis (HP:0100732)3.17731448
25Generalized tonic-clonic seizures (HP:0002069)3.15375805
26Pancreatic cysts (HP:0001737)3.06259529
27Drooling (HP:0002307)3.03131339
28Hypothermia (HP:0002045)3.01142626
29Anxiety (HP:0000739)2.95596394
30Primary atrial arrhythmia (HP:0001692)2.91750346
31Hemiplegia (HP:0002301)2.91618772
32Atrial fibrillation (HP:0005110)2.91344044
33Prolonged QT interval (HP:0001657)2.88953304
34Colon cancer (HP:0003003)2.85476604
35Megalencephaly (HP:0001355)2.82010658
36Failure to thrive in infancy (HP:0001531)2.80791013
37Hyperventilation (HP:0002883)2.80751163
38Supraventricular tachycardia (HP:0004755)2.79487043
39Myotonia (HP:0002486)2.75930175
40Excessive salivation (HP:0003781)2.75589885
41Mitochondrial inheritance (HP:0001427)2.72495679
42Supraventricular arrhythmia (HP:0005115)2.72075348
43Nephronophthisis (HP:0000090)2.71232413
44Depression (HP:0000716)2.69333147
45Aplasia/Hypoplasia of the tongue (HP:0010295)2.65606963
46Progressive inability to walk (HP:0002505)2.61554867
47Action tremor (HP:0002345)2.60326689
48Gait imbalance (HP:0002141)2.59169140
49Ventricular fibrillation (HP:0001663)2.55238740
50Torticollis (HP:0000473)2.55224721
51Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.52347057
52Abnormality of the labia minora (HP:0012880)2.49434887
53Calf muscle hypertrophy (HP:0008981)2.49263300
54Aplasia/Hypoplasia of the tibia (HP:0005772)2.47024093
55Abnormal EKG (HP:0003115)2.43959852
56Abnormal ciliary motility (HP:0012262)2.39796210
57Muscle hypertrophy of the lower extremities (HP:0008968)2.39492419
58Exercise-induced myalgia (HP:0003738)2.37162139
59Neoplasm of the peripheral nervous system (HP:0100007)2.37154364
60Truncal ataxia (HP:0002078)2.36127269
61Volvulus (HP:0002580)2.35749409
62Gaze-evoked nystagmus (HP:0000640)2.33885871
63Increased CSF lactate (HP:0002490)2.33773887
64Medial flaring of the eyebrow (HP:0010747)2.33551823
65Optic nerve hypoplasia (HP:0000609)2.33307180
66Dysmetria (HP:0001310)2.31504946
67Postaxial hand polydactyly (HP:0001162)2.31405757
68Congenital primary aphakia (HP:0007707)2.30190692
69Broad-based gait (HP:0002136)2.30049652
70Ankle clonus (HP:0011448)2.28633651
71Dysdiadochokinesis (HP:0002075)2.26039773
72Inability to walk (HP:0002540)2.25743254
73Anencephaly (HP:0002323)2.25334748
74Focal dystonia (HP:0004373)2.22987825
75Abnormal respiratory epithelium morphology (HP:0012253)2.21388074
76Abnormal respiratory motile cilium morphology (HP:0005938)2.21388074
77Craniofacial dystonia (HP:0012179)2.21224261
78Bifid tongue (HP:0010297)2.20968237
79Tented upper lip vermilion (HP:0010804)2.20130772
80Hepatoblastoma (HP:0002884)2.20030580
81Left ventricular hypertrophy (HP:0001712)2.19564111
82Dynein arm defect of respiratory motile cilia (HP:0012255)2.19141504
83Absent/shortened dynein arms (HP:0200106)2.19141504
84Septo-optic dysplasia (HP:0100842)2.17773241
85Sclerocornea (HP:0000647)2.17631475
86Abnormality of the calf musculature (HP:0001430)2.16989332
87Postaxial foot polydactyly (HP:0001830)2.15894945
88Lissencephaly (HP:0001339)2.13857785
89Nephrogenic diabetes insipidus (HP:0009806)2.13813007
90Vaginal atresia (HP:0000148)2.13156315
91Poor coordination (HP:0002370)2.13156086
92Protruding tongue (HP:0010808)2.12495061
93Short tibia (HP:0005736)2.12382184
94Genital tract atresia (HP:0001827)2.10887868
95Broad foot (HP:0001769)2.10599103
96Abnormal eating behavior (HP:0100738)2.10501752
97Cerebral edema (HP:0002181)2.09841897
98Hypoventilation (HP:0002791)2.09445789
99Scanning speech (HP:0002168)2.06356493
100Cerebral hemorrhage (HP:0001342)2.06125161
101Optic disc pallor (HP:0000543)2.04604686
102Pachygyria (HP:0001302)2.04476989
103Renal hypoplasia (HP:0000089)2.03763103
104Cystic liver disease (HP:0006706)2.02864578
105Hepatocellular necrosis (HP:0001404)2.02829086
106Absent speech (HP:0001344)2.02524477
107Amblyopia (HP:0000646)2.01305591
108Preaxial hand polydactyly (HP:0001177)2.00471130
109Termporal pattern (HP:0011008)1.99695641
110Insidious onset (HP:0003587)1.99695641
111Central scotoma (HP:0000603)1.99027276
112Intestinal atresia (HP:0011100)1.99004846
113Short 4th metacarpal (HP:0010044)1.98551599
114Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.98551599
115Abnormality of the vocal cords (HP:0008777)1.98027341
116Abnormality of midbrain morphology (HP:0002418)1.97957941
117Molar tooth sign on MRI (HP:0002419)1.97957941
118Abnormality of binocular vision (HP:0011514)1.97684336
119Diplopia (HP:0000651)1.97684336
120Specific learning disability (HP:0001328)1.96933258
121Split foot (HP:0001839)1.95978471
122Impaired vibration sensation in the lower limbs (HP:0002166)1.95464405
123Dysmetric saccades (HP:0000641)1.95163507
124Bradykinesia (HP:0002067)1.94544668
125Oligomenorrhea (HP:0000876)1.94042943
126Abnormal respiratory motile cilium physiology (HP:0012261)1.93783732
127Abnormality of the renal medulla (HP:0100957)1.93782570
128Bundle branch block (HP:0011710)1.93701235
129Abnormal hair whorl (HP:0010721)1.91784546
130Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.91761370
131Aplasia/Hypoplasia of the sternum (HP:0006714)1.91206315
132Agitation (HP:0000713)1.90921505
133Impaired pain sensation (HP:0007328)1.90628758
134Abnormality of pain sensation (HP:0010832)1.90628758
135Epileptiform EEG discharges (HP:0011182)1.90563959
136Supranuclear gaze palsy (HP:0000605)1.90132637
137Rib fusion (HP:0000902)1.89649033
138Bradycardia (HP:0001662)1.89346709
139Cerebral inclusion bodies (HP:0100314)1.87452621
140Abnormal lung lobation (HP:0002101)1.87337866
141Incomplete penetrance (HP:0003829)1.85764676
142Fibular hypoplasia (HP:0003038)1.84802283
143EEG with generalized epileptiform discharges (HP:0011198)1.84618731
144Poor eye contact (HP:0000817)1.83734535
145Neoplasm of the oral cavity (HP:0100649)1.83709208
146Decreased testicular size (HP:0008734)1.83293158
147Poor suck (HP:0002033)1.82638062
148Abnormality of salivation (HP:0100755)1.82226630
149Stomach cancer (HP:0012126)1.81130388
150Respiratory failure (HP:0002878)1.80953959
151Aplasia/Hypoplasia of the lens (HP:0008063)1.80176637
152Anosmia (HP:0000458)1.80167586
153Abnormal social behavior (HP:0012433)1.79748945
154Impaired social interactions (HP:0000735)1.79748945
155Abnormality of macular pigmentation (HP:0008002)1.79258085
156Epidermoid cyst (HP:0200040)1.78946490
157Ulnar claw (HP:0001178)1.78918944
158Polyphagia (HP:0002591)1.78892064
159Conjunctival hamartoma (HP:0100780)1.78075150
160Renal cortical cysts (HP:0000803)1.77592912
161Narrow forehead (HP:0000341)1.75914803
162Preaxial foot polydactyly (HP:0001841)1.74396333
163Humeroradial synostosis (HP:0003041)1.72196186
164Synostosis involving the elbow (HP:0003938)1.72196186
165Gastroesophageal reflux (HP:0002020)1.70509427
166Micropenis (HP:0000054)1.69852784
167Exercise-induced muscle cramps (HP:0003710)1.69626994
168Exotropia (HP:0000577)1.69461203
169Abnormality of the diencephalon (HP:0010662)1.68842871

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK3.14805026
2MAP3K123.08470690
3NTRK33.00192871
4MAP3K43.00085399
5MAP2K72.74451045
6PHKG12.59368829
7PHKG22.59368829
8MAP3K92.57879318
9GRK52.49337903
10WNK32.41932253
11MINK12.35800705
12MARK12.17484020
13MAP4K22.13759509
14PNCK2.13206405
15MAP2K41.95848677
16EPHA41.95764804
17ARAF1.93305277
18PLK21.90860214
19DAPK21.90233934
20DYRK21.88432726
21CAMK2D1.71906162
22NEK21.71889839
23PLK41.60105948
24LMTK21.59577049
25CAMK2A1.52793892
26CAMK2B1.52198545
27CAMKK21.51806906
28PAK31.49898193
29EPHB21.47766552
30CSNK1G21.47337169
31PRKCG1.44126035
32NUAK11.42500746
33CSNK1G31.40208734
34CAMK2G1.38766795
35NTRK21.37331021
36GRK71.34721481
37MAPK151.34258120
38PAK61.33590046
39MAPKAPK51.32855815
40DAPK11.32569504
41MYLK1.31776048
42MKNK21.24237430
43KSR21.22730190
44MAPK131.22414036
45CDK51.20651932
46NTRK11.15875964
47DYRK31.13255249
48KSR11.13052242
49PRPF4B1.09339670
50CAMK1G1.08674407
51PTK2B1.07121286
52NEK11.04650278
53SIK21.01896892
54FER1.00805698
55CAMKK11.00788240
56CCNB10.96631234
57FGFR20.91913471
58SRPK10.91132968
59SGK4940.89573158
60SGK2230.89573158
61CDK190.88407498
62PRKCE0.87953488
63CSNK1G10.87838728
64CAMK10.87485554
65PKN10.87079985
66STK390.86213114
67WNK40.86182466
68PDK30.83594126
69PDK40.83594126
70MKNK10.83259342
71WNK10.82130494
72RPS6KA40.81695603
73FES0.80681666
74UHMK10.79300940
75ADRBK20.78979216
76CDK140.78255550
77GRK60.77233318
78ZAK0.76742494
79TRIM280.76178555
80CDK180.75625913
81NME10.75310945
82OXSR10.74875049
83TNIK0.74458913
84BMPR1B0.73887145
85CSNK1A1L0.71757413
86CDK150.70788214
87PINK10.70752429
88SGK20.68526360
89LATS20.68140059
90DMPK0.67933593
91EPHA30.66956882
92ADRBK10.66073955
93TIE10.65831077
94RET0.65710824
95AKT30.64875646
96CSNK1A10.64665539
97DYRK1A0.64566519
98STK380.64475242
99ERBB30.63903124
100STK110.62113770
101RAF10.62012320
102RIPK10.60766320
103FGR0.60546772
104CDK11A0.57517817
105ROCK20.57468894
106MAP3K10.57355374
107BCR0.57061873
108MAP3K130.55468583
109RIPK40.54582951
110CAMK40.54293062
111CDK30.54174431
112YES10.53971362
113DAPK30.53909895
114ILK0.53166623
115SIK30.51379043
116PRKACA0.50738712
117ROCK10.50597447
118WEE10.49900297
119PRKACB0.49026195
120MAP2K10.48282260
121FRK0.47955751
122BCKDK0.47689617
123PRKCZ0.47381522
124PRKD30.46636300
125SGK10.46533516
126STK240.45459656
127MARK20.45239805
128TTN0.44881620
129PRKCH0.44704327
130TNK20.42483137
131OBSCN0.42314122
132VRK10.42169809
133PRKG10.40041194
134CSNK1D0.37655414
135PLK30.34553374
136CSNK1E0.32559271
137PIK3CA0.32484391
138TAOK10.30235852
139RPS6KA30.28631687
140MAPK40.25503918
141MAPK100.24810284
142PRKCB0.24334658

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047404.81052863
2Synaptic vesicle cycle_Homo sapiens_hsa047213.35543231
3Nicotine addiction_Homo sapiens_hsa050333.26363939
4Oxidative phosphorylation_Homo sapiens_hsa001902.56048114
5Parkinsons disease_Homo sapiens_hsa050122.45970358
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.44527869
7Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.38697036
8GABAergic synapse_Homo sapiens_hsa047272.35485410
9Steroid biosynthesis_Homo sapiens_hsa001002.33734472
10Circadian entrainment_Homo sapiens_hsa047132.29713613
11Morphine addiction_Homo sapiens_hsa050322.29117943
12Cardiac muscle contraction_Homo sapiens_hsa042602.17270597
13Collecting duct acid secretion_Homo sapiens_hsa049662.17086673
14Amphetamine addiction_Homo sapiens_hsa050312.13831530
15Dopaminergic synapse_Homo sapiens_hsa047282.11616676
16Vitamin B6 metabolism_Homo sapiens_hsa007502.06128679
17Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.04015675
18Glutamatergic synapse_Homo sapiens_hsa047242.02169909
19Taste transduction_Homo sapiens_hsa047421.93506807
20Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.90961493
21Alzheimers disease_Homo sapiens_hsa050101.88394202
22Insulin secretion_Homo sapiens_hsa049111.86728420
23Long-term potentiation_Homo sapiens_hsa047201.86347910
24Cocaine addiction_Homo sapiens_hsa050301.83391723
25Salivary secretion_Homo sapiens_hsa049701.77519549
26Cholinergic synapse_Homo sapiens_hsa047251.71462578
27Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.63862008
28Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.62504120
29Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.56565523
30Serotonergic synapse_Homo sapiens_hsa047261.54424405
31Vibrio cholerae infection_Homo sapiens_hsa051101.53855875
32Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.52892123
33Renin secretion_Homo sapiens_hsa049241.50948337
34Gastric acid secretion_Homo sapiens_hsa049711.50009943
35Aldosterone synthesis and secretion_Homo sapiens_hsa049251.48860375
36Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.47485945
37Calcium signaling pathway_Homo sapiens_hsa040201.47167297
38Nitrogen metabolism_Homo sapiens_hsa009101.46997511
39Huntingtons disease_Homo sapiens_hsa050161.44977542
40Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.35029431
41Dilated cardiomyopathy_Homo sapiens_hsa054141.29989003
42Oxytocin signaling pathway_Homo sapiens_hsa049211.27839000
43Gap junction_Homo sapiens_hsa045401.27168663
44cAMP signaling pathway_Homo sapiens_hsa040241.25930939
45Long-term depression_Homo sapiens_hsa047301.18946756
46Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.11273268
47Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.08764229
48Basal cell carcinoma_Homo sapiens_hsa052171.06999879
49Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.06956421
50GnRH signaling pathway_Homo sapiens_hsa049121.06232491
51Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.06061743
52Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.02444789
53Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.01832361
54cGMP-PKG signaling pathway_Homo sapiens_hsa040220.99951796
55Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.98863703
562-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.96806459
57Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.94701889
58Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.92328678
59Estrogen signaling pathway_Homo sapiens_hsa049150.91687521
60Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.91073411
61Vascular smooth muscle contraction_Homo sapiens_hsa042700.87436107
62Fatty acid elongation_Homo sapiens_hsa000620.85611902
63Primary bile acid biosynthesis_Homo sapiens_hsa001200.83174471
64Fatty acid metabolism_Homo sapiens_hsa012120.82970860
65Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.81895843
66Phototransduction_Homo sapiens_hsa047440.81460733
67Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.80804667
68Pyruvate metabolism_Homo sapiens_hsa006200.76851721
69Basal transcription factors_Homo sapiens_hsa030220.75523591
70Thyroid hormone synthesis_Homo sapiens_hsa049180.74355284
71Hedgehog signaling pathway_Homo sapiens_hsa043400.73030307
72Melanogenesis_Homo sapiens_hsa049160.72175432
73Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.71869650
74Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.71708126
75Pancreatic secretion_Homo sapiens_hsa049720.69976378
76Hippo signaling pathway_Homo sapiens_hsa043900.69292147
77Alcoholism_Homo sapiens_hsa050340.66974201
78Glucagon signaling pathway_Homo sapiens_hsa049220.65915511
79Peroxisome_Homo sapiens_hsa041460.65640111
80Phosphatidylinositol signaling system_Homo sapiens_hsa040700.65504921
81Propanoate metabolism_Homo sapiens_hsa006400.64958258
82Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.61712911
83Axon guidance_Homo sapiens_hsa043600.61524499
84Type II diabetes mellitus_Homo sapiens_hsa049300.61308630
85Oocyte meiosis_Homo sapiens_hsa041140.59445204
86Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.57969988
87Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.56789157
88Circadian rhythm_Homo sapiens_hsa047100.54452869
89Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.53679969
90Regulation of autophagy_Homo sapiens_hsa041400.53264826
91Fanconi anemia pathway_Homo sapiens_hsa034600.51735583
92Wnt signaling pathway_Homo sapiens_hsa043100.51014999
93Glioma_Homo sapiens_hsa052140.50862755
94Arginine and proline metabolism_Homo sapiens_hsa003300.50558138
95Tryptophan metabolism_Homo sapiens_hsa003800.49514542
96Dorso-ventral axis formation_Homo sapiens_hsa043200.47510436
97Histidine metabolism_Homo sapiens_hsa003400.47455743
98Butanoate metabolism_Homo sapiens_hsa006500.45945082
99Bile secretion_Homo sapiens_hsa049760.43745436
100ErbB signaling pathway_Homo sapiens_hsa040120.43031960
101Protein export_Homo sapiens_hsa030600.42861691
102Rheumatoid arthritis_Homo sapiens_hsa053230.42049827
103Ovarian steroidogenesis_Homo sapiens_hsa049130.41502080
104Rap1 signaling pathway_Homo sapiens_hsa040150.41481910
105TGF-beta signaling pathway_Homo sapiens_hsa043500.40421842
106Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.39715516
107RNA degradation_Homo sapiens_hsa030180.39173372
108Ether lipid metabolism_Homo sapiens_hsa005650.38623451
109Insulin signaling pathway_Homo sapiens_hsa049100.38600627
110alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.37776365
111Fatty acid biosynthesis_Homo sapiens_hsa000610.37691674
112Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.37539714
113MAPK signaling pathway_Homo sapiens_hsa040100.37152797
114Caffeine metabolism_Homo sapiens_hsa002320.36119714
115Phospholipase D signaling pathway_Homo sapiens_hsa040720.35580320
116Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.35548332
117beta-Alanine metabolism_Homo sapiens_hsa004100.35255514
118Ras signaling pathway_Homo sapiens_hsa040140.34256806
119Carbon metabolism_Homo sapiens_hsa012000.33984091
120Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.32732238
121Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.32011747
122Phenylalanine metabolism_Homo sapiens_hsa003600.31580958
123Longevity regulating pathway - mammal_Homo sapiens_hsa042110.29782917
124Phagosome_Homo sapiens_hsa041450.28101482
125Sulfur metabolism_Homo sapiens_hsa009200.26612802
126SNARE interactions in vesicular transport_Homo sapiens_hsa041300.25735223
127Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.25684290
128Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.25491383
129Inositol phosphate metabolism_Homo sapiens_hsa005620.24242224
130Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.24025059
131Neurotrophin signaling pathway_Homo sapiens_hsa047220.23492724
132Thyroid hormone signaling pathway_Homo sapiens_hsa049190.22550469
133Tyrosine metabolism_Homo sapiens_hsa003500.21508884
134Type I diabetes mellitus_Homo sapiens_hsa049400.20792565
135Melanoma_Homo sapiens_hsa052180.18467756
136Renal cell carcinoma_Homo sapiens_hsa052110.17788625

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »