LRRC41

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)7.56734601
2Golgi transport vesicle coating (GO:0048200)7.56734601
3fusion of sperm to egg plasma membrane (GO:0007342)5.75963627
4sperm-egg recognition (GO:0035036)5.25287373
5binding of sperm to zona pellucida (GO:0007339)5.21968620
6sperm motility (GO:0030317)5.11102711
7piRNA metabolic process (GO:0034587)5.09963871
8maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.97123057
9exocrine pancreas development (GO:0031017)4.52646839
10axonemal dynein complex assembly (GO:0070286)4.51590663
11protein retention in ER lumen (GO:0006621)4.50951602
12plasma membrane fusion (GO:0045026)4.41757322
13cell-cell recognition (GO:0009988)4.40867920
14COPII vesicle coating (GO:0048208)4.33614713
15acrosome reaction (GO:0007340)4.22363716
16motile cilium assembly (GO:0044458)4.22306898
17retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.09393289
18synaptonemal complex organization (GO:0070193)4.00967607
19synaptonemal complex assembly (GO:0007130)3.95197642
20multicellular organism reproduction (GO:0032504)3.92971926
21cilium or flagellum-dependent cell motility (GO:0001539)3.89428384
22activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.86337371
23gonadal mesoderm development (GO:0007506)3.79443273
24spermatid development (GO:0007286)3.78092265
25cellular response to unfolded protein (GO:0034620)3.65046707
26acrosome assembly (GO:0001675)3.64298868
27positive regulation of nuclease activity (GO:0032075)3.64221138
28positive regulation of male gonad development (GO:2000020)3.64183618
29endoplasmic reticulum unfolded protein response (GO:0030968)3.63499027
30reproduction (GO:0000003)3.57515626
31GDP-mannose metabolic process (GO:0019673)3.55808244
32vascular endothelial growth factor signaling pathway (GO:0038084)3.50585600
33cellular response to topologically incorrect protein (GO:0035967)3.49614754
34gene silencing by RNA (GO:0031047)3.48925220
35seminiferous tubule development (GO:0072520)3.47883886
36regulation of male gonad development (GO:2000018)3.46629089
37planar cell polarity pathway involved in neural tube closure (GO:0090179)3.46374243
38male meiosis (GO:0007140)3.42925979
39type B pancreatic cell proliferation (GO:0044342)3.42128932
40endosome to melanosome transport (GO:0035646)3.39147187
41endosome to pigment granule transport (GO:0043485)3.39147187
42regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.37895416
43vesicle coating (GO:0006901)3.34806433
44regulation of nuclease activity (GO:0032069)3.21989372
45ER-nucleus signaling pathway (GO:0006984)3.21017286
46hemidesmosome assembly (GO:0031581)3.18739815
47proline biosynthetic process (GO:0006561)3.15649523
48peptidyl-proline hydroxylation (GO:0019511)3.12873348
49negative regulation of cell size (GO:0045792)3.12001273
50snRNA metabolic process (GO:0016073)3.11912081
51low-density lipoprotein particle clearance (GO:0034383)3.10480719
52type B pancreatic cell development (GO:0003323)3.09399134
53snRNA processing (GO:0016180)3.07326767
54regulation of mitochondrial translation (GO:0070129)3.05270962
55left/right pattern formation (GO:0060972)3.04149862
56positive regulation of macrophage activation (GO:0043032)3.02358804
57barbed-end actin filament capping (GO:0051016)3.01176299
58endocardial cushion development (GO:0003197)3.00736574
59response to unfolded protein (GO:0006986)2.97523805
60purine ribonucleotide transport (GO:0015868)2.97085099
61protein heterotrimerization (GO:0070208)2.95734266
62cell wall macromolecule catabolic process (GO:0016998)2.95704776
63cell wall macromolecule metabolic process (GO:0044036)2.95704776
64regulation of translational fidelity (GO:0006450)2.94951868
65DNA methylation involved in gamete generation (GO:0043046)2.93934271
66protein hydroxylation (GO:0018126)2.93100498
67chondrocyte proliferation (GO:0035988)2.92761313
68anatomical structure regression (GO:0060033)2.91263713
69protein maturation by protein folding (GO:0022417)2.90829770
70cell migration involved in heart development (GO:0060973)2.89680679
71regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.89078631
72organic cation transport (GO:0015695)2.88601033
73collagen fibril organization (GO:0030199)2.88514193
74UV protection (GO:0009650)2.88371002
75response to topologically incorrect protein (GO:0035966)2.86631178
76peptidyl-arginine omega-N-methylation (GO:0035247)2.85359565
77regulation of cilium movement (GO:0003352)2.84765149
78response to endoplasmic reticulum stress (GO:0034976)2.84387320
79bone trabecula formation (GO:0060346)2.84140368
80phosphate ion transmembrane transport (GO:0035435)2.84102427
81cell-substrate junction assembly (GO:0007044)2.83908273
824-hydroxyproline metabolic process (GO:0019471)2.82588351
83nuclear envelope reassembly (GO:0031468)2.82545387
84mitotic nuclear envelope reassembly (GO:0007084)2.82545387
85ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)2.79734446
86regulation of vitamin D biosynthetic process (GO:0060556)2.79694313
87epithelial cilium movement (GO:0003351)2.78934368
88apoptotic cell clearance (GO:0043277)2.74810852
89adherens junction assembly (GO:0034333)2.74633409
90epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.74316724
91proline metabolic process (GO:0006560)2.72731225
92skin morphogenesis (GO:0043589)2.72728008
93spermatogenesis (GO:0007283)2.71630772
94adenine nucleotide transport (GO:0051503)2.71000420
95Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.70117094
96male gamete generation (GO:0048232)2.70008711
97single fertilization (GO:0007338)2.69953621
98endothelial cell chemotaxis (GO:0035767)2.69386169
99regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.68308605
100regulation of establishment of planar polarity (GO:0090175)2.68271597
101cellular response to vitamin D (GO:0071305)2.67736494
102tooth mineralization (GO:0034505)2.67626217
103regulation of apoptotic process involved in morphogenesis (GO:1902337)2.65513273
104negative regulation of fatty acid transport (GO:2000192)2.63781323
105basement membrane organization (GO:0071711)2.62185022
106regulation of mammary gland epithelial cell proliferation (GO:0033599)2.61812975
107desmosome organization (GO:0002934)2.61105470
108ER to Golgi vesicle-mediated transport (GO:0006888)2.60487130
109extracellular fibril organization (GO:0043206)2.60470483
110galactose catabolic process (GO:0019388)2.59867312
111fertilization (GO:0009566)2.59375905
112growth hormone secretion (GO:0030252)2.58623137
113polarized epithelial cell differentiation (GO:0030859)2.54598135
114cell-substrate adherens junction assembly (GO:0007045)2.53855704
115focal adhesion assembly (GO:0048041)2.53855704
116sex differentiation (GO:0007548)2.51715858
117phosphate ion transport (GO:0006817)2.50866069
118cellular response to vitamin (GO:0071295)2.50141021
119positive regulation of natural killer cell differentiation (GO:0032825)2.49673615
120sex determination (GO:0007530)2.46726696
121glandular epithelial cell development (GO:0002068)2.46113906
122cochlea morphogenesis (GO:0090103)2.45302198
123positive regulation of epithelial to mesenchymal transition (GO:0010718)2.43895292
124adhesion of symbiont to host (GO:0044406)2.43812235
125positive regulation of hormone biosynthetic process (GO:0046886)2.42894868
126ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.42144063
127oocyte development (GO:0048599)2.42117879
128nucleosome disassembly (GO:0006337)2.41981915
129protein-DNA complex disassembly (GO:0032986)2.41981915
130gamete generation (GO:0007276)2.41428241
131membrane protein intracellular domain proteolysis (GO:0031293)2.40986795
132peptidyl-asparagine modification (GO:0018196)2.40889590
133protein N-linked glycosylation via asparagine (GO:0018279)2.40767538
134endodermal cell differentiation (GO:0035987)2.40266290
135positive regulation of protein kinase C signaling (GO:0090037)2.40200417
136non-canonical Wnt signaling pathway (GO:0035567)2.39403633
137glomerular basement membrane development (GO:0032836)2.38875676
138germ cell development (GO:0007281)2.38515867
139atrioventricular valve morphogenesis (GO:0003181)2.38458019
140convergent extension (GO:0060026)2.37725001
141regulation of tight junction assembly (GO:2000810)2.36918043
142regulation of hippo signaling (GO:0035330)2.36332542
143purine nucleoside bisphosphate biosynthetic process (GO:0034033)2.36263195
144ribonucleoside bisphosphate biosynthetic process (GO:0034030)2.36263195
145nucleoside bisphosphate biosynthetic process (GO:0033866)2.36263195
146regulation of fatty acid beta-oxidation (GO:0031998)2.34553253
147establishment of apical/basal cell polarity (GO:0035089)2.34075621
148embryonic skeletal joint morphogenesis (GO:0060272)2.30300073
149fibril organization (GO:0097435)2.30162472
150endothelial cell morphogenesis (GO:0001886)2.30092521
151cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.29581972
152misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.29302303
153spliceosomal tri-snRNP complex assembly (GO:0000244)2.28051832
154positive regulation of receptor biosynthetic process (GO:0010870)2.27829964
155positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.27460989
156semaphorin-plexin signaling pathway (GO:0071526)2.26854561
157purine nucleotide transport (GO:0015865)2.26593551
158cranial nerve morphogenesis (GO:0021602)2.25945093
159vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.25122995
160positive regulation of transforming growth factor beta receptor signaling pathway (GO:0030511)2.24982084
161folic acid metabolic process (GO:0046655)2.24688888
162heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.23176450
163mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.22343005
164protein insertion into membrane (GO:0051205)2.22206172
165peptidyl-glutamic acid carboxylation (GO:0017187)2.21102238
166protein carboxylation (GO:0018214)2.21102238
167biotin metabolic process (GO:0006768)2.20648404
168positive regulation of smoothened signaling pathway (GO:0045880)2.20072616
169G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.18705238
170positive regulation of hormone metabolic process (GO:0032352)2.16801646
171paraxial mesoderm development (GO:0048339)2.16444257
172regulation of cardioblast differentiation (GO:0051890)2.16061211
173mannose metabolic process (GO:0006013)2.15651856
174lens fiber cell development (GO:0070307)2.14597337

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse6.58561772
2STAT6_21828071_ChIP-Seq_BEAS2B_Human3.72253059
3RARG_19884340_ChIP-ChIP_MEFs_Mouse3.16108139
4TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.73509990
5PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.63102583
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.54516627
7TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.42594988
8TP63_17297297_ChIP-ChIP_HaCaT_Human2.37602003
9DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.29835529
10PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.26842229
11RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.26536711
12ZNF263_19887448_ChIP-Seq_K562_Human2.23012040
13EGR1_19374776_ChIP-ChIP_THP-1_Human2.10427235
14TRIM28_21343339_ChIP-Seq_HEK293_Human1.93309641
15* HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.91985559
16CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.91870036
17EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.90864515
18XRN2_22483619_ChIP-Seq_HELA_Human1.85496231
19STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.80201701
20HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.75921598
21ELK3_25401928_ChIP-Seq_HUVEC_Human1.70992118
22EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.70006705
23* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.68730711
24TP53_22127205_ChIP-Seq_IMR90_Human1.66973875
25ELF1_20517297_ChIP-Seq_JURKAT_Human1.63181553
26FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.60960644
27SRY_22984422_ChIP-ChIP_TESTIS_Rat1.58784003
28JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.58753922
29RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.53710387
30* LXR_22292898_ChIP-Seq_THP-1_Human1.52991877
31CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.51833442
32ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.50680473
33CLOCK_20551151_ChIP-Seq_293T_Human1.49048087
34KDM2B_26808549_Chip-Seq_SUP-B15_Human1.46420879
35CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.45998168
36NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.45730828
37ESR1_21235772_ChIP-Seq_MCF-7_Human1.43303668
38ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.42160381
39WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.41523778
40* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.41518670
41CREB1_26743006_Chip-Seq_LNCaP_Human1.39481403
42THAP11_20581084_ChIP-Seq_MESCs_Mouse1.37753815
43TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.36316058
44ERG_21242973_ChIP-ChIP_JURKAT_Human1.36265584
45ZNF274_21170338_ChIP-Seq_K562_Hela1.35494477
46YY1_22570637_ChIP-Seq_MALME-3M_Human1.34538162
47SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.34159877
48AR_21909140_ChIP-Seq_LNCAP_Human1.34115691
49BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.33633286
50EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.32285602
51* CTCF_27219007_Chip-Seq_Bcells_Human1.31644243
52* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.31585215
53DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.31557891
54* RACK7_27058665_Chip-Seq_MCF-7_Human1.30881341
55HIF1A_21447827_ChIP-Seq_MCF-7_Human1.29758082
56* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.29460184
57* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.27246711
58CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.26672395
59KDM5A_27292631_Chip-Seq_BREAST_Human1.25530095
60NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.23857056
61PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.22691928
62TET1_21451524_ChIP-Seq_MESCs_Mouse1.22141350
63ATF3_27146783_Chip-Seq_COLON_Human1.21537394
64* KDM2B_26808549_Chip-Seq_DND41_Human1.20615629
65SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.20114526
66RARA_24833708_ChIP-Seq_LIVER_Mouse1.18494693
67TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.17298111
68TET1_21490601_ChIP-Seq_MESCs_Mouse1.17008410
69* BCL6_27268052_Chip-Seq_Bcells_Human1.15683990
70DNAJC2_21179169_ChIP-ChIP_NT2_Human1.15591144
71ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.15367971
72ESR2_21235772_ChIP-Seq_MCF-7_Human1.15246624
73CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.15075811
74KDM2B_26808549_Chip-Seq_K562_Human1.15006363
75ZFP281_18757296_ChIP-ChIP_E14_Mouse1.14581981
76* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.13871144
77FOXP1_21924763_ChIP-Seq_HESCs_Human1.13844121
78TP53_20018659_ChIP-ChIP_R1E_Mouse1.13615221
79P68_20966046_ChIP-Seq_HELA_Human1.13352182
80TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13287099
81ESR1_15608294_ChIP-ChIP_MCF-7_Human1.13076164
82RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.12876286
83CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.12840654
84TP63_22573176_ChIP-Seq_HFKS_Human1.11901088
85ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.10571308
86DCP1A_22483619_ChIP-Seq_HELA_Human1.10530697
87MYC_22102868_ChIP-Seq_BL_Human1.10224273
88TBX5_21415370_ChIP-Seq_HL-1_Mouse1.09910498
89LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.09834745
90KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.09575218
91* UBF1/2_26484160_Chip-Seq_HMECs_Human1.09574672
92PHF8_20622854_ChIP-Seq_HELA_Human1.09276523
93POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.08684935
94CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.08642472
95TP53_23651856_ChIP-Seq_MEFs_Mouse1.08554588
96* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.07575694
97SMC3_22415368_ChIP-Seq_MEFs_Mouse1.07523610
98SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.07371874
99* CTCF_20526341_ChIP-Seq_ESCs_Human1.06874994
100NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.06738056
101TP63_19390658_ChIP-ChIP_HaCaT_Human1.06522572
102* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.06445969
103NELFA_20434984_ChIP-Seq_ESCs_Mouse1.06136054
104E2F1_18555785_ChIP-Seq_MESCs_Mouse1.04752400
105GABP_19822575_ChIP-Seq_HepG2_Human1.04654804
106ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.04307826
107TFEB_21752829_ChIP-Seq_HELA_Human1.03574115
108FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.03286807
109* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.03070984
110JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.02281095
111EED_16625203_ChIP-ChIP_MESCs_Mouse1.01779795
112MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.01336124
113GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.01147521
114VDR_21846776_ChIP-Seq_THP-1_Human1.01095034
115MYC_18358816_ChIP-ChIP_MESCs_Mouse1.00928777
116ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.00825491
117* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.00672157
118CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.00143084
119NCOR1_26117541_ChIP-Seq_K562_Human0.99746566
120BCOR_27268052_Chip-Seq_Bcells_Human0.99286243
121* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.99272390
122MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.99150845
123* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.98745585
124P63_26484246_Chip-Seq_KERATINOCYTES_Human0.97784140
125SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.97403222
126RARB_24833708_ChIP-Seq_LIVER_Mouse0.96871828
127NFI_21473784_ChIP-Seq_ESCs_Mouse0.96490743
128BRD4_25478319_ChIP-Seq_HGPS_Human0.95684978
129CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.95539837
130SMC4_20622854_ChIP-Seq_HELA_Human0.94208591
131FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93748484
132* SA1_27219007_Chip-Seq_ERYTHROID_Human0.93497990
133MYC_18555785_ChIP-Seq_MESCs_Mouse0.92441746
134TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.92268659
135PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.91888936
136THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.91269103
137SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.91037750
138RAD21_21589869_ChIP-Seq_MESCs_Mouse0.90343667
139JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.90282716
140TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.89818674
141CTCF_18555785_ChIP-Seq_MESCs_Mouse0.89409107
142EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.89383538

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization5.02332119
2MP0008438_abnormal_cutaneous_collagen4.71125058
3MP0005503_abnormal_tendon_morphology3.23506096
4MP0006054_spinal_hemorrhage2.94345416
5MP0003705_abnormal_hypodermis_morpholog2.86612259
6MP0004858_abnormal_nervous_system2.33116376
7MP0003279_aneurysm2.29716307
8MP0005275_abnormal_skin_tensile2.28159945
9MP0005171_absent_coat_pigmentation2.07649165
10MP0000751_myopathy2.07095906
11MP0004272_abnormal_basement_membrane2.06934738
12MP0005257_abnormal_intraocular_pressure2.04181060
13MP0009384_cardiac_valve_regurgitation1.98466738
14MP0003942_abnormal_urinary_system1.86507600
15MP0001958_emphysema1.84622737
16MP0010352_gastrointestinal_tract_polyps1.74773863
17MP0000534_abnormal_ureter_morphology1.74395153
18MP0002877_abnormal_melanocyte_morpholog1.72749937
19MP0003122_maternal_imprinting1.66661403
20MP0005220_abnormal_exocrine_pancreas1.66263754
21MP0003698_abnormal_male_reproductive1.64185882
22MP0004233_abnormal_muscle_weight1.63306430
23MP0001929_abnormal_gametogenesis1.62641658
24MP0005623_abnormal_meninges_morphology1.62586436
25MP0000678_abnormal_parathyroid_gland1.57757855
26MP0010368_abnormal_lymphatic_system1.53300149
27MP0005508_abnormal_skeleton_morphology1.50893663
28MP0009278_abnormal_bone_marrow1.50778105
29MP0002295_abnormal_pulmonary_circulatio1.49299573
30MP0005670_abnormal_white_adipose1.49032652
31MP0000462_abnormal_digestive_system1.47032898
32MP0002938_white_spotting1.45866135
33MP0001727_abnormal_embryo_implantation1.42553520
34MP0002249_abnormal_larynx_morphology1.41775198
35MP0000013_abnormal_adipose_tissue1.40613697
36MP0000538_abnormal_urinary_bladder1.40270844
37MP0005023_abnormal_wound_healing1.40177769
38MP0003566_abnormal_cell_adhesion1.39834627
39MP0009250_abnormal_appendicular_skeleto1.39259405
40MP0004264_abnormal_extraembryonic_tissu1.38654801
41MP0002896_abnormal_bone_mineralization1.35531297
42MP0002089_abnormal_postnatal_growth/wei1.35510837
43MP0003385_abnormal_body_wall1.32562523
44MP0005076_abnormal_cell_differentiation1.32168997
45MP0002060_abnormal_skin_morphology1.27945994
46MP0003123_paternal_imprinting1.27935507
47MP0004134_abnormal_chest_morphology1.27102405
48MP0001299_abnormal_eye_distance/1.26873692
49MP0003091_abnormal_cell_migration1.26685552
50MP0003195_calcinosis1.26478112
51MP0008877_abnormal_DNA_methylation1.25628095
52MP0003115_abnormal_respiratory_system1.23975003
53MP0002282_abnormal_trachea_morphology1.22147444
54MP0002653_abnormal_ependyma_morphology1.21051924
55MP0009053_abnormal_anal_canal1.20742904
56MP0000733_abnormal_muscle_development1.18812219
57MP0010030_abnormal_orbit_morphology1.17202271
58MP0001661_extended_life_span1.16487671
59MP0002210_abnormal_sex_determination1.16101286
60MP0003941_abnormal_skin_development1.16037316
61MP0000569_abnormal_digit_pigmentation1.15159843
62MP0000537_abnormal_urethra_morphology1.14922739
63MP0005451_abnormal_body_composition1.12786351
64MP0009780_abnormal_chondrocyte_physiolo1.11662546
65MP0003283_abnormal_digestive_organ1.11507033
66MP0001944_abnormal_pancreas_morphology1.11432784
67MP0005367_renal/urinary_system_phenotyp1.10885926
68MP0000516_abnormal_urinary_system1.10885926
69MP0000750_abnormal_muscle_regeneration1.08658332
70MP0001243_abnormal_dermal_layer1.06416355
71MP0003315_abnormal_perineum_morphology1.06108762
72MP0004133_heterotaxia1.04950837
73MP0001145_abnormal_male_reproductive1.04724019
74MP0003959_abnormal_lean_body1.04565452
75MP0009840_abnormal_foam_cell1.03441825
76MP0000762_abnormal_tongue_morphology1.02335262
77MP0003300_gastrointestinal_ulcer1.01746122
78MP0002168_other_aberrant_phenotype1.01545077
79MP0005330_cardiomyopathy0.99855254
80MP0000759_abnormal_skeletal_muscle0.98948091
81MP0008007_abnormal_cellular_replicative0.98577887
82MP0002932_abnormal_joint_morphology0.98466276
83MP0002161_abnormal_fertility/fecundity0.97908122
84MP0005083_abnormal_biliary_tract0.96964272
85MP0005375_adipose_tissue_phenotype0.95046567
86MP0000003_abnormal_adipose_tissue0.94892533
87MP0005390_skeleton_phenotype0.94011923
88MP0000767_abnormal_smooth_muscle0.92903148
89MP0000467_abnormal_esophagus_morphology0.92737344
90MP0002693_abnormal_pancreas_physiology0.92282384
91MP0008932_abnormal_embryonic_tissue0.90547440
92MP0004197_abnormal_fetal_growth/weight/0.88599253
93MP0002115_abnormal_skeleton_extremities0.87009611
94MP0000163_abnormal_cartilage_morphology0.86224098
95MP0000653_abnormal_sex_gland0.86215072
96MP0003795_abnormal_bone_structure0.85831154
97MP0010386_abnormal_urinary_bladder0.85579103
98MP0004808_abnormal_hematopoietic_stem0.85429090
99MP0001849_ear_inflammation0.85113936
100MP0003755_abnormal_palate_morphology0.84074217
101MP0000428_abnormal_craniofacial_morphol0.83879635
102MP0002113_abnormal_skeleton_development0.83839280
103MP0005501_abnormal_skin_physiology0.83000709
104MP0001270_distended_abdomen0.82316491
105MP0001915_intracranial_hemorrhage0.80930129
106MP0003172_abnormal_lysosome_physiology0.80328462
107MP0001879_abnormal_lymphatic_vessel0.79972272
108MP0003111_abnormal_nucleus_morphology0.79092168
109MP0002114_abnormal_axial_skeleton0.78868205
110MP0008260_abnormal_autophagy0.78846296
111MP0005197_abnormal_uvea_morphology0.77868616
112MP0001502_abnormal_circadian_rhythm0.77840050
113MP0002108_abnormal_muscle_morphology0.76948490
114MP0003937_abnormal_limbs/digits/tail_de0.76553166
115MP0002933_joint_inflammation0.76153949
116MP0001756_abnormal_urination0.75930523
117MP0002396_abnormal_hematopoietic_system0.75422327
118MP0000358_abnormal_cell_content/0.74564998
119MP0005621_abnormal_cell_physiology0.74188234
120MP0001545_abnormal_hematopoietic_system0.73648761
121MP0005397_hematopoietic_system_phenotyp0.73648761
122MP0003878_abnormal_ear_physiology0.73604999
123MP0005377_hearing/vestibular/ear_phenot0.73604999
124MP0002697_abnormal_eye_size0.73424480
125MP0000049_abnormal_middle_ear0.72947789
126MP0002160_abnormal_reproductive_system0.72832393
127MP0003984_embryonic_growth_retardation0.72171287
128MP0000566_synostosis0.71938653
129MP0002111_abnormal_tail_morphology0.71864166
130MP0003935_abnormal_craniofacial_develop0.71715688
131MP0001614_abnormal_blood_vessel0.71515043
132MP0000858_altered_metastatic_potential0.71248187
133MP0010771_integument_phenotype0.71243267
134MP0002128_abnormal_blood_circulation0.70528317
135MP0002116_abnormal_craniofacial_bone0.69791595
136MP0002109_abnormal_limb_morphology0.68953867
137MP0005464_abnormal_platelet_physiology0.68597847
138MP0005058_abnormal_lysosome_morphology0.67888551
139MP0001533_abnormal_skeleton_physiology0.67527417
140MP0002177_abnormal_outer_ear0.67476834
141MP0002085_abnormal_embryonic_tissue0.65547185
142MP0002088_abnormal_embryonic_growth/wei0.65401502
143MP0000579_abnormal_nail_morphology0.64673825
144MP0000747_muscle_weakness0.64296551

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)5.63185613
2Premature rupture of membranes (HP:0001788)4.76557855
3Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.89879364
4Hand muscle atrophy (HP:0009130)3.84833212
5Ulnar bowing (HP:0003031)3.73495598
6Abnormality of dentin (HP:0010299)3.56169957
7Dynein arm defect of respiratory motile cilia (HP:0012255)3.50908807
8Absent/shortened dynein arms (HP:0200106)3.50908807
9Peritonitis (HP:0002586)3.47646260
10Natal tooth (HP:0000695)3.43200867
11Upper limb amyotrophy (HP:0009129)3.33467314
12Distal upper limb amyotrophy (HP:0007149)3.33467314
13Cervical subluxation (HP:0003308)3.18274146
14Ankle contracture (HP:0006466)3.07769368
15Bladder diverticulum (HP:0000015)3.03595251
16Aortic aneurysm (HP:0004942)2.90907780
17Chronic bronchitis (HP:0004469)2.88267416
18Aortic dissection (HP:0002647)2.85713491
19Soft skin (HP:0000977)2.81141102
20Thin bony cortex (HP:0002753)2.79468545
21Male infertility (HP:0003251)2.73832914
22Premature skin wrinkling (HP:0100678)2.73582424
23Hyperinsulinemic hypoglycemia (HP:0000825)2.60535212
24Bell-shaped thorax (HP:0001591)2.57618143
25Testicular atrophy (HP:0000029)2.56522128
26Spinal rigidity (HP:0003306)2.52993409
27Cerebral aneurysm (HP:0004944)2.52397430
28Infertility (HP:0000789)2.50322229
29Fragile skin (HP:0001030)2.49770486
30Nasal polyposis (HP:0100582)2.47975020
31Follicular hyperkeratosis (HP:0007502)2.44836334
32Difficulty climbing stairs (HP:0003551)2.42771492
33Abnormality of the acetabulum (HP:0003170)2.41142062
34Bowel diverticulosis (HP:0005222)2.40561020
3511 pairs of ribs (HP:0000878)2.39897730
36Bowed forearm bones (HP:0003956)2.38056757
37Bowing of the arm (HP:0006488)2.38056757
38Hypoglycemic seizures (HP:0002173)2.36211208
39Achilles tendon contracture (HP:0001771)2.35690214
40Shallow orbits (HP:0000586)2.35287812
41Atrophic scars (HP:0001075)2.32036572
42Abnormal respiratory epithelium morphology (HP:0012253)2.30454895
43Abnormal respiratory motile cilium morphology (HP:0005938)2.30454895
44Gonadotropin excess (HP:0000837)2.28277170
45Fibular hypoplasia (HP:0003038)2.26778219
46Broad metatarsal (HP:0001783)2.25475952
47Tetraparesis (HP:0002273)2.22974932
48Abnormal delivery (HP:0001787)2.21880121
49Rhinitis (HP:0012384)2.21325986
50Advanced eruption of teeth (HP:0006288)2.20912702
51Renal duplication (HP:0000075)2.20822263
52Blue sclerae (HP:0000592)2.20779022
53Congenital glaucoma (HP:0001087)2.20449608
54Wrist flexion contracture (HP:0001239)2.19659411
55Elbow flexion contracture (HP:0002987)2.18075287
56Dilatation of the ascending aorta (HP:0005111)2.13861138
57Vertebral compression fractures (HP:0002953)2.13641247
58Breech presentation (HP:0001623)2.13195051
59Abnormality of the nasal mucosa (HP:0000433)2.12293955
60Abnormality of the peritoneum (HP:0002585)2.11475075
61Hyperacusis (HP:0010780)2.10605909
62Abnormality of the Achilles tendon (HP:0005109)2.10160167
63Entropion (HP:0000621)2.06582879
64Coronal craniosynostosis (HP:0004440)2.06189283
65Mildly elevated creatine phosphokinase (HP:0008180)2.05995195
66Abnormality of the distal phalanges of the toes (HP:0010182)2.05720937
67Hypoglycemic coma (HP:0001325)2.05119033
68Femoral bowing (HP:0002980)2.03846480
69Abnormality of endocrine pancreas physiology (HP:0012093)2.02687625
70Abnormality of the pancreatic islet cells (HP:0006476)2.02687625
71Asymmetry of the thorax (HP:0001555)2.00359132
72Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.99145678
73Upper limb muscle weakness (HP:0003484)1.99070835
74Disproportionate tall stature (HP:0001519)1.96423798
75Ectopia lentis (HP:0001083)1.95568959
76Wormian bones (HP:0002645)1.95363740
77Breast hypoplasia (HP:0003187)1.94893742
78Abnormal gallbladder physiology (HP:0012438)1.93680795
79Cholecystitis (HP:0001082)1.93680795
80Stridor (HP:0010307)1.93667111
81Aneurysm (HP:0002617)1.93585490
82Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.93573620
83Turricephaly (HP:0000262)1.93281589
84Nonimmune hydrops fetalis (HP:0001790)1.93089267
85Congenital hip dislocation (HP:0001374)1.92604711
86Reticulocytosis (HP:0001923)1.92319522
87Elfin facies (HP:0004428)1.91931566
88Abnormal respiratory motile cilium physiology (HP:0012261)1.91355363
89Biconcave vertebral bodies (HP:0004586)1.90661741
90Inguinal hernia (HP:0000023)1.90626337
91Hypoventilation (HP:0002791)1.89583785
92Joint laxity (HP:0001388)1.87825336
93Radial bowing (HP:0002986)1.85599262
94Hyperextensible skin (HP:0000974)1.84998162
95Degeneration of anterior horn cells (HP:0002398)1.84538688
96Abnormality of the anterior horn cell (HP:0006802)1.84538688
97Genu recurvatum (HP:0002816)1.84284776
98Platyspondyly (HP:0000926)1.84091881
99Lymphangioma (HP:0100764)1.84075365
100Wide anterior fontanel (HP:0000260)1.83485264
101Rhizomelia (HP:0008905)1.82849965
102Short nail (HP:0001799)1.81815061
103Aplasia/Hypoplasia of the fibula (HP:0006492)1.81593015
104Pterygium (HP:0001059)1.81032272
105Sparse lateral eyebrow (HP:0005338)1.80844397
106Pancreatic islet-cell hyperplasia (HP:0004510)1.80258882
107Neonatal short-limb short stature (HP:0008921)1.80172265
108Symptomatic seizures (HP:0011145)1.80008576
109Mitral valve prolapse (HP:0001634)1.79936031
110Poikiloderma (HP:0001029)1.79844304
111Buphthalmos (HP:0000557)1.78918928
112Missing ribs (HP:0000921)1.78713935
113Trismus (HP:0000211)1.77510309
114Spinal cord compression (HP:0002176)1.77054550
115Broad face (HP:0000283)1.77019561
116Atelectasis (HP:0100750)1.76911663
117Selective tooth agenesis (HP:0001592)1.76717878
118Short 4th metacarpal (HP:0010044)1.75990842
119Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.75990842
120Insulin-resistant diabetes mellitus (HP:0000831)1.75563803
121Broad ribs (HP:0000885)1.74789292
122Hypoplasia of the capital femoral epiphysis (HP:0003090)1.73825264
123Mitral stenosis (HP:0001718)1.73769053
124Osteoarthritis (HP:0002758)1.73310584
125Abnormal umbilical cord blood vessels (HP:0011403)1.72868251
126Single umbilical artery (HP:0001195)1.72868251
127Abnormality of the fetal cardiovascular system (HP:0010948)1.72868251
128Increased variability in muscle fiber diameter (HP:0003557)1.72620743
129Abnormality of the calcaneus (HP:0008364)1.72202446
130Tibial bowing (HP:0002982)1.72060408
131Tubulointerstitial fibrosis (HP:0005576)1.71996958
132Tubular atrophy (HP:0000092)1.71859434
133Aplasia/Hypoplasia of the clavicles (HP:0006710)1.71209774
134Thin ribs (HP:0000883)1.70795924
135Distal lower limb amyotrophy (HP:0008944)1.70379994
136Aplastic anemia (HP:0001915)1.70114972
137Long toe (HP:0010511)1.70037424
138Joint stiffness (HP:0001387)1.69999456
139Hyperparathyroidism (HP:0000843)1.69983712
140Deviation of the hallux (HP:0010051)1.69681116
141Insulin resistance (HP:0000855)1.69653237
142Facial cleft (HP:0002006)1.69559802
143Abnormality of the umbilical cord (HP:0010881)1.68744435
144Back pain (HP:0003418)1.66853741
145Broad distal phalanx of finger (HP:0009836)1.66573006
146Mitral regurgitation (HP:0001653)1.65858435
147Short 5th finger (HP:0009237)1.65480722
148Slender long bone (HP:0003100)1.65425212
149Flat acetabular roof (HP:0003180)1.65233649
150Hypoplasia of the iris (HP:0007676)1.64256645
151Type 1 muscle fiber predominance (HP:0003803)1.63858432
152Mesangial abnormality (HP:0001966)1.62933891
153Ovoid vertebral bodies (HP:0003300)1.62437794
154Abnormality of carpal bone ossification (HP:0006257)1.61282520
155Arachnodactyly (HP:0001166)1.60113994
156Fibular aplasia (HP:0002990)1.58177033
157Patellar aplasia (HP:0006443)1.57631611
158Bronchomalacia (HP:0002780)1.57228351
159Protruding ear (HP:0000411)1.57187123
160Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.55446755
161Long palpebral fissure (HP:0000637)1.54858628
162Athetosis (HP:0002305)1.54807505

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.38864714
2PRKD34.30519815
3TESK14.18405285
4PDK33.00525222
5PDK43.00525222
6PASK2.87009077
7ERN12.86306469
8ICK2.79709742
9MAP3K32.70788640
10EEF2K2.67550475
11SMG12.54810783
12CDK122.27698748
13PDGFRA2.02119057
14PRKD21.94793140
15INSRR1.85467814
16MAPK151.84473411
17PTK61.83260117
18AKT31.79289549
19PDK21.76596878
20RPS6KA41.66863606
21PKN21.65294806
22NME21.59023677
23BLK1.56777004
24DYRK1B1.54450659
25PAK21.52931195
26DDR21.52254715
27PIM21.51963937
28FLT31.49757159
29MAP3K21.47893455
30EPHA31.44492055
31EPHB11.43893275
32SIK11.42040204
33DAPK31.36804499
34MAP3K101.35578157
35PIK3CG1.32187211
36MAP2K21.29915767
37PTK21.27808750
38MTOR1.22892609
39LATS21.22879684
40TAOK31.18999213
41TTN1.18504040
42RIPK11.17002948
43LMTK21.13241672
44CCNB11.09758623
45MAPK111.08332446
46CSNK1A1L1.00555435
47NEK20.98331887
48IRAK30.97687277
49MAPKAPK30.96749029
50MET0.95628167
51MAP3K60.93189765
52BCKDK0.91952075
53TBK10.91862563
54EPHB20.90858281
55TGFBR10.90055456
56STK380.88704370
57PAK40.87593479
58WNK30.87286210
59LIMK10.86176098
60MST1R0.84392429
61PTK2B0.82764526
62CSNK1G30.82374463
63PAK60.81810644
64PRPF4B0.80702613
65CHEK20.80484847
66KDR0.80260152
67MAP2K10.77844103
68VRK20.76729350
69RPS6KL10.76297380
70RPS6KC10.76297380
71CAMK1D0.76230911
72LATS10.72925416
73PRKAA10.70111719
74EPHA20.69474842
75BRSK10.68839891
76PAK10.68371688
77RET0.67751078
78RPS6KA60.66675635
79MARK20.66445674
80ARAF0.66308949
81CDK70.65984186
82MAP3K80.65318324
83FER0.64926035
84DYRK30.64307631
85AURKA0.63824227
86PAK30.63435114
87BMX0.61495509
88PDPK10.59973140
89CAMK1G0.59700574
90BRD40.59278002
91FGFR40.59195981
92ABL20.58559373
93BUB10.56895802
94FRK0.56476482
95KIT0.55439555
96SCYL20.55141702
97CHUK0.54895219
98PDGFRB0.54605837
99BTK0.53648739
100CSNK1G10.53493518
101LRRK20.53304807
102MAPKAPK50.52727374
103GSK3A0.52634323
104RPS6KB20.51811712
105RPS6KB10.51366796
106NTRK10.48309900
107STK30.47928903
108TESK20.47307385
109PRKD10.44861243
110TAOK20.43159507
111CDK11A0.42803597
112MAP3K70.42506841
113IRAK10.42273484
114PRKAA20.41938280
115MAP3K110.41152484
116CDC42BPA0.40867856
117ATR0.40627605
118CDK150.39702437
119JAK30.38997014
120MYLK0.37638929
121WNK40.36146954
122PBK0.35274872
123ERBB30.35216186
124MAP3K10.34708949
125ZAP700.33888011
126CDK180.33654513
127PKN10.33519634
128PRKCI0.33448560
129PHKG10.33040660
130PHKG20.33040660
131AKT20.32806835
132TYRO30.31334828
133RPS6KA20.30712488
134CDK80.30175191
135MAPKAPK20.29055376
136CAMK2G0.27988205
137HIPK20.26128786
138NEK90.25571935
139RPS6KA50.23690170
140MELK0.23683072
141CDK40.23554329
142PRKG20.22750519
143CHEK10.22096855
144ILK0.21046423

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein processing in endoplasmic reticulum_Homo sapiens_hsa041413.95730642
2Sulfur relay system_Homo sapiens_hsa041223.82241637
3Maturity onset diabetes of the young_Homo sapiens_hsa049503.28640291
42-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.64500295
5Protein export_Homo sapiens_hsa030602.48350420
6Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.46470982
7Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.37892175
8Protein digestion and absorption_Homo sapiens_hsa049742.18833861
9Legionellosis_Homo sapiens_hsa051342.14742711
10ECM-receptor interaction_Homo sapiens_hsa045122.11377764
11Lysine degradation_Homo sapiens_hsa003102.05078643
12N-Glycan biosynthesis_Homo sapiens_hsa005102.02303778
13Biosynthesis of amino acids_Homo sapiens_hsa012301.98681574
14Selenocompound metabolism_Homo sapiens_hsa004501.88892185
15Sulfur metabolism_Homo sapiens_hsa009201.77645591
16Cyanoamino acid metabolism_Homo sapiens_hsa004601.73297081
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.64768675
18Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.61091986
19Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.57616945
20Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.57150626
21Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.52683603
22Focal adhesion_Homo sapiens_hsa045101.49022857
23Glycosaminoglycan degradation_Homo sapiens_hsa005311.44630241
24Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.44434182
25Carbon metabolism_Homo sapiens_hsa012001.36177865
26Bladder cancer_Homo sapiens_hsa052191.35211332
27Chronic myeloid leukemia_Homo sapiens_hsa052201.33011829
28Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.32522111
29Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.30947363
30One carbon pool by folate_Homo sapiens_hsa006701.29707939
31Fatty acid elongation_Homo sapiens_hsa000621.28226890
32Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.25562883
33Pentose phosphate pathway_Homo sapiens_hsa000301.24797613
34Fat digestion and absorption_Homo sapiens_hsa049751.24382295
35Shigellosis_Homo sapiens_hsa051311.22666615
36Central carbon metabolism in cancer_Homo sapiens_hsa052301.22104918
37Vitamin digestion and absorption_Homo sapiens_hsa049771.20416888
38Vitamin B6 metabolism_Homo sapiens_hsa007501.19265054
39Viral carcinogenesis_Homo sapiens_hsa052031.18137603
40Adherens junction_Homo sapiens_hsa045201.16422047
41Lysosome_Homo sapiens_hsa041421.11630086
42Hedgehog signaling pathway_Homo sapiens_hsa043401.08996716
43Carbohydrate digestion and absorption_Homo sapiens_hsa049731.05532432
44SNARE interactions in vesicular transport_Homo sapiens_hsa041301.04349341
45Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.02299777
46Hippo signaling pathway_Homo sapiens_hsa043901.01502272
47Arginine and proline metabolism_Homo sapiens_hsa003301.01226268
48Proteoglycans in cancer_Homo sapiens_hsa052051.01092806
49Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.00512307
50Renin-angiotensin system_Homo sapiens_hsa046140.99929578
51TGF-beta signaling pathway_Homo sapiens_hsa043500.99654289
52Amoebiasis_Homo sapiens_hsa051460.98618559
53RNA transport_Homo sapiens_hsa030130.97780233
54Acute myeloid leukemia_Homo sapiens_hsa052210.97012523
55AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.97005032
56Arginine biosynthesis_Homo sapiens_hsa002200.95870738
57Pancreatic cancer_Homo sapiens_hsa052120.95056779
58Sphingolipid metabolism_Homo sapiens_hsa006000.94586637
59Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.92345364
60Small cell lung cancer_Homo sapiens_hsa052220.92216370
61alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.91246474
62Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.90129818
63Phenylalanine metabolism_Homo sapiens_hsa003600.86980792
64Toxoplasmosis_Homo sapiens_hsa051450.86108541
65PI3K-Akt signaling pathway_Homo sapiens_hsa041510.86020276
66Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.86013345
67Fructose and mannose metabolism_Homo sapiens_hsa000510.85580034
68Phagosome_Homo sapiens_hsa041450.84760554
69Tyrosine metabolism_Homo sapiens_hsa003500.82890861
70Vibrio cholerae infection_Homo sapiens_hsa051100.82779714
71Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.82029644
72Fatty acid biosynthesis_Homo sapiens_hsa000610.81673102
73Thyroid hormone signaling pathway_Homo sapiens_hsa049190.80926609
74Antigen processing and presentation_Homo sapiens_hsa046120.80542288
75Galactose metabolism_Homo sapiens_hsa000520.80102707
76Glucagon signaling pathway_Homo sapiens_hsa049220.80096960
77Pyruvate metabolism_Homo sapiens_hsa006200.80040041
78mTOR signaling pathway_Homo sapiens_hsa041500.79616609
79MicroRNAs in cancer_Homo sapiens_hsa052060.77656045
80Adipocytokine signaling pathway_Homo sapiens_hsa049200.77268768
81Other glycan degradation_Homo sapiens_hsa005110.76033497
82Insulin resistance_Homo sapiens_hsa049310.74884682
83Folate biosynthesis_Homo sapiens_hsa007900.74829254
84Apoptosis_Homo sapiens_hsa042100.74562239
85Basal cell carcinoma_Homo sapiens_hsa052170.74437709
86Notch signaling pathway_Homo sapiens_hsa043300.73429565
87p53 signaling pathway_Homo sapiens_hsa041150.73030867
88Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.72375481
89Melanoma_Homo sapiens_hsa052180.72109772
90Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.72034369
91HTLV-I infection_Homo sapiens_hsa051660.71964506
92Prion diseases_Homo sapiens_hsa050200.71013997
93TNF signaling pathway_Homo sapiens_hsa046680.70274102
94Fatty acid metabolism_Homo sapiens_hsa012120.69487706
95Cell cycle_Homo sapiens_hsa041100.69320412
96Alcoholism_Homo sapiens_hsa050340.68759415
97Linoleic acid metabolism_Homo sapiens_hsa005910.67112840
98Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.67025737
99Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.66881306
100Glutathione metabolism_Homo sapiens_hsa004800.64908199
101Hepatitis B_Homo sapiens_hsa051610.64162833
102AMPK signaling pathway_Homo sapiens_hsa041520.63940543
103Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.63710601
104Systemic lupus erythematosus_Homo sapiens_hsa053220.62644330
105Dilated cardiomyopathy_Homo sapiens_hsa054140.61147455
106Prostate cancer_Homo sapiens_hsa052150.58920889
107HIF-1 signaling pathway_Homo sapiens_hsa040660.58825962
108Pyrimidine metabolism_Homo sapiens_hsa002400.56363094
109Influenza A_Homo sapiens_hsa051640.55858646
110Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.55820229
111Salmonella infection_Homo sapiens_hsa051320.54778131
112Malaria_Homo sapiens_hsa051440.54392126
113Cysteine and methionine metabolism_Homo sapiens_hsa002700.53187488
114Prolactin signaling pathway_Homo sapiens_hsa049170.52310058
115Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.48781671
116Toll-like receptor signaling pathway_Homo sapiens_hsa046200.48170458
117Glioma_Homo sapiens_hsa052140.47402533
118Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.46519443
119PPAR signaling pathway_Homo sapiens_hsa033200.46255798
120Basal transcription factors_Homo sapiens_hsa030220.46015409
121Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.45860668
122Type II diabetes mellitus_Homo sapiens_hsa049300.45578398
123Tight junction_Homo sapiens_hsa045300.45573132
124Steroid biosynthesis_Homo sapiens_hsa001000.45295592
125Estrogen signaling pathway_Homo sapiens_hsa049150.45202802
126Metabolic pathways_Homo sapiens_hsa011000.45010233
127Melanogenesis_Homo sapiens_hsa049160.44855833
128Axon guidance_Homo sapiens_hsa043600.42424957
129Neurotrophin signaling pathway_Homo sapiens_hsa047220.41794883
130Viral myocarditis_Homo sapiens_hsa054160.41333224
131Base excision repair_Homo sapiens_hsa034100.41227277
132Insulin signaling pathway_Homo sapiens_hsa049100.40096414
133Longevity regulating pathway - mammal_Homo sapiens_hsa042110.39483203
134Fatty acid degradation_Homo sapiens_hsa000710.38393324
135Epstein-Barr virus infection_Homo sapiens_hsa051690.38327159
136Pathways in cancer_Homo sapiens_hsa052000.37906297
137Endometrial cancer_Homo sapiens_hsa052130.36786664
138Inositol phosphate metabolism_Homo sapiens_hsa005620.36532574
139Endocytosis_Homo sapiens_hsa041440.35868493
140Butanoate metabolism_Homo sapiens_hsa006500.35403687
141Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.31651604

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