LRRC46

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1binding of sperm to zona pellucida (GO:0007339)9.90155460
2cell-cell recognition (GO:0009988)9.83846218
3regulation of cilium movement (GO:0003352)9.55261739
4plasma membrane fusion (GO:0045026)9.49103355
5motile cilium assembly (GO:0044458)9.42002680
6cilium movement (GO:0003341)9.18984599
7piRNA metabolic process (GO:0034587)9.11641306
8spermatid development (GO:0007286)9.08095766
9reproduction (GO:0000003)8.82733977
10male meiosis (GO:0007140)8.42963937
11epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)8.17933017
12synaptonemal complex organization (GO:0070193)7.70182493
13primary alcohol catabolic process (GO:0034310)7.54969311
14synaptonemal complex assembly (GO:0007130)7.47682060
15sperm capacitation (GO:0048240)7.40960274
16single fertilization (GO:0007338)7.37620805
17left/right axis specification (GO:0070986)7.08800599
18vitamin transmembrane transport (GO:0035461)6.94552510
19ventricular system development (GO:0021591)6.66138353
20microtubule bundle formation (GO:0001578)6.49908693
21ethanol metabolic process (GO:0006067)6.32306078
22fertilization (GO:0009566)6.25912201
23diterpenoid biosynthetic process (GO:0016102)6.05799814
24spermatogenesis (GO:0007283)5.95160208
25male gamete generation (GO:0048232)5.92962637
26negative regulation of inclusion body assembly (GO:0090084)5.92566755
27microtubule severing (GO:0051013)5.84987141
28organic cation transport (GO:0015695)5.78236627
29male meiosis I (GO:0007141)5.65709108
30DNA methylation involved in gamete generation (GO:0043046)5.62410817
31regulation of microtubule-based movement (GO:0060632)5.61815846
32gamete generation (GO:0007276)5.45033838
33tolerance induction (GO:0002507)5.44842919
34pyrimidine-containing compound transmembrane transport (GO:0072531)5.35560269
35response to xenobiotic stimulus (GO:0009410)5.29773083
36chromosome organization involved in meiosis (GO:0070192)5.23081275
37cellular process involved in reproduction in multicellular organism (GO:0022412)5.19458174
38germ cell development (GO:0007281)5.18507187
39lung epithelium development (GO:0060428)5.15317548
40one-carbon compound transport (GO:0019755)5.09854344
41microtubule depolymerization (GO:0007019)5.06384036
42regulation of inclusion body assembly (GO:0090083)4.96565145
43protein polyglutamylation (GO:0018095)4.95665181
44meiotic nuclear division (GO:0007126)4.93632694
45establishment of apical/basal cell polarity (GO:0035089)4.90655134
46negative regulation of T cell differentiation in thymus (GO:0033085)4.80476309
47cell recognition (GO:0008037)4.75629655
48negative regulation of immunoglobulin mediated immune response (GO:0002890)4.73663285
49negative regulation of B cell mediated immunity (GO:0002713)4.73663285
50seminiferous tubule development (GO:0072520)4.72931482
51glomerular epithelial cell development (GO:0072310)4.66357699
52regulation of interleukin-5 production (GO:0032674)4.65089179
53calcium ion-dependent exocytosis (GO:0017156)4.64743996
54ethanol oxidation (GO:0006069)4.62112485
55protein localization to cilium (GO:0061512)4.60643994
56meiosis I (GO:0007127)4.53141186
57negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)4.50658148
58negative regulation of humoral immune response (GO:0002921)4.46216807
59left/right pattern formation (GO:0060972)4.39130091
60regulation of germinal center formation (GO:0002634)4.36578427
61positive regulation of tolerance induction (GO:0002645)4.31819587
62multicellular organismal reproductive process (GO:0048609)4.30102833
63regulation of interleukin-13 production (GO:0032656)4.27375587
64establishment or maintenance of monopolar cell polarity (GO:0061339)4.24192210
65establishment of monopolar cell polarity (GO:0061162)4.24192210
66meiotic cell cycle (GO:0051321)4.23745837
67cell projection assembly (GO:0030031)4.20819143
68terpenoid biosynthetic process (GO:0016114)4.15831199
69spermatid nucleus differentiation (GO:0007289)4.05230585
70retinoic acid metabolic process (GO:0042573)4.04393179
71cytoplasmic microtubule organization (GO:0031122)3.90410240
72genitalia morphogenesis (GO:0035112)3.87707936
73chromosome condensation (GO:0030261)3.81270095
74intraciliary transport (GO:0042073)3.76236458
75axoneme assembly (GO:0035082)3.75573457
76DNA packaging (GO:0006323)3.64955069
77monoubiquitinated protein deubiquitination (GO:0035520)3.56967693
78exogenous drug catabolic process (GO:0042738)3.49214428
79lateral ventricle development (GO:0021670)3.47158802
80multicellular organismal development (GO:0007275)3.46662133
81establishment of planar polarity (GO:0001736)3.42926979
82establishment of tissue polarity (GO:0007164)3.42926979
83cilium organization (GO:0044782)3.41986578
84gene silencing by RNA (GO:0031047)3.39789309
85regulation of response to osmotic stress (GO:0047484)3.36235841
86chaperone-mediated protein complex assembly (GO:0051131)3.32783453
87glycerol ether metabolic process (GO:0006662)3.31570288
88primary alcohol metabolic process (GO:0034308)3.31026316
89microtubule-based movement (GO:0007018)3.30584298
90nucleoside diphosphate phosphorylation (GO:0006165)3.29102779
91negative regulation of organelle assembly (GO:1902116)3.26731213
92regulation of tolerance induction (GO:0002643)3.25039540
93cilium assembly (GO:0042384)3.24194217
94O-glycan processing (GO:0016266)3.23015042
95synapsis (GO:0007129)3.20369733
96positive regulation of smoothened signaling pathway (GO:0045880)3.20114875
97retinol metabolic process (GO:0042572)3.15647162
98meiotic cell cycle process (GO:1903046)3.13903111
99regulation of microtubule depolymerization (GO:0031114)3.10469969
100glutathione derivative metabolic process (GO:1901685)3.10401901
101glutathione derivative biosynthetic process (GO:1901687)3.10401901
102hydrogen peroxide biosynthetic process (GO:0050665)3.10243768
103cellular component assembly involved in morphogenesis (GO:0010927)3.09847702
104peptidyl-glutamic acid modification (GO:0018200)3.07859139
105ether metabolic process (GO:0018904)3.05500979
106nuclear pore complex assembly (GO:0051292)3.05199756
107multicellular organismal water homeostasis (GO:0050891)3.01987340
108regulation of spindle checkpoint (GO:0090231)3.00189560
109amino-acid betaine transport (GO:0015838)3.00061270
110carnitine transport (GO:0015879)3.00061270
111cilium morphogenesis (GO:0060271)2.99395657
112aldehyde catabolic process (GO:0046185)2.96985922
113phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.95784576
114regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.95627943
115carnitine transmembrane transport (GO:1902603)2.94602917
116regulation of centriole replication (GO:0046599)2.89757806
117carnitine metabolic process (GO:0009437)2.85102316
118apical protein localization (GO:0045176)2.83753542
119determination of left/right symmetry (GO:0007368)2.83717562
120nucleus organization (GO:0006997)2.83548364
121microtubule-based process (GO:0007017)2.80592681
122hypotonic response (GO:0006971)2.79590640
123centriole assembly (GO:0098534)2.78099018
124lateral sprouting from an epithelium (GO:0060601)2.77597394
125glycolytic process (GO:0006096)2.77187396
126reactive oxygen species biosynthetic process (GO:1903409)2.75397958
127single strand break repair (GO:0000012)2.74123593
128determination of bilateral symmetry (GO:0009855)2.73579586
129progesterone metabolic process (GO:0042448)2.72625344
130centriole replication (GO:0007099)2.69592340
131protein refolding (GO:0042026)2.69431885
132GTP biosynthetic process (GO:0006183)2.68570855
133specification of symmetry (GO:0009799)2.67656307
134hydrogen peroxide catabolic process (GO:0042744)2.67138296
135drug catabolic process (GO:0042737)2.66987826
136protein localization to chromosome, centromeric region (GO:0071459)2.64308153
137dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.63190087
138regulation of autophagic vacuole assembly (GO:2000785)2.62505047
139interferon-gamma secretion (GO:0072643)2.61018005
140DNA replication-dependent nucleosome assembly (GO:0006335)2.60167591
141DNA replication-dependent nucleosome organization (GO:0034723)2.60167591
142RNA localization (GO:0006403)2.59761818
143regulation of meiosis I (GO:0060631)2.58661874
144phosphatidylcholine biosynthetic process (GO:0006656)2.57509156
145gene silencing (GO:0016458)2.57050890
146organelle assembly (GO:0070925)2.56544646
147smoothened signaling pathway (GO:0007224)2.56389545
148retinal rod cell development (GO:0046548)2.56224405
149regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 2.55516312
150excretion (GO:0007588)2.55251845
151water homeostasis (GO:0030104)2.55007554
152calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.53317950
153negative regulation of microtubule depolymerization (GO:0007026)2.52205125
154pore complex assembly (GO:0046931)2.50779393
155iron ion import (GO:0097286)2.49752870
156alditol metabolic process (GO:0019400)2.47267206
157oligosaccharide biosynthetic process (GO:0009312)2.47262631
158protein K11-linked deubiquitination (GO:0035871)2.47215934
159microtubule polymerization or depolymerization (GO:0031109)2.46847991
160lactate metabolic process (GO:0006089)2.46786405
161regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.44588140
162heart looping (GO:0001947)2.41834723
163cilium or flagellum-dependent cell motility (GO:0001539)13.3104544
164fusion of sperm to egg plasma membrane (GO:0007342)12.5316178
165sperm motility (GO:0030317)12.3097951
166acrosome assembly (GO:0001675)11.1767158
167sperm-egg recognition (GO:0035036)11.0180594
168axonemal dynein complex assembly (GO:0070286)10.9380492
169multicellular organism reproduction (GO:0032504)10.7694365
170acrosome reaction (GO:0007340)10.5973435
171cell wall macromolecule metabolic process (GO:0044036)10.4197829
172cell wall macromolecule catabolic process (GO:0016998)10.4197829
173epithelial cilium movement (GO:0003351)10.0316178

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.79199221
2EZH2_22144423_ChIP-Seq_EOC_Human4.62197727
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.69063192
4FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human3.46120744
5DROSHA_22980978_ChIP-Seq_HELA_Human3.46120445
6BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.98659493
7TRIM28_21343339_ChIP-Seq_HEK293_Human2.72601512
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.59019450
9ESR1_20079471_ChIP-ChIP_T-47D_Human2.50716242
10PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.43409023
11VDR_22108803_ChIP-Seq_LS180_Human2.35684786
12ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.28703921
13STAT6_21828071_ChIP-Seq_BEAS2B_Human2.26872168
14CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.18702322
15GATA1_26923725_Chip-Seq_HPCs_Mouse2.18509881
16FLI1_27457419_Chip-Seq_LIVER_Mouse2.12841458
17SMC4_20622854_ChIP-Seq_HELA_Human2.11704544
18RUNX1_27514584_Chip-Seq_MCF-7_Human2.11118641
19ESR2_21235772_ChIP-Seq_MCF-7_Human2.10753780
20TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.10704801
21* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.10036157
22ESR1_21235772_ChIP-Seq_MCF-7_Human2.04483036
23SOX2_27498859_Chip-Seq_STOMACH_Mouse2.01607051
24MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse10.5733027
25ELK4_26923725_Chip-Seq_MESODERM_Mouse1.98796929
26PCGF2_27294783_Chip-Seq_ESCs_Mouse1.98310826
27AHR_22903824_ChIP-Seq_MCF-7_Human1.89222417
28FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.88830499
29EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.84082508
30KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.75927178
31CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.72125470
32TP63_22573176_ChIP-Seq_HFKS_Human1.66304067
33P63_26484246_Chip-Seq_KERATINOCYTES_Human1.65981529
34CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.64826517
35FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.64785713
36KLF5_25053715_ChIP-Seq_YYC3_Human1.64671827
37ZNF274_21170338_ChIP-Seq_K562_Hela1.61870269
38PCGF2_27294783_Chip-Seq_NPCs_Mouse1.60992674
39KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.60811218
40GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.60654625
41AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.59116010
42TP63_23658742_ChIP-Seq_EP156T_Human1.57635670
43TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.56957613
44ARNT_22903824_ChIP-Seq_MCF-7_Human1.54305962
45ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.52984549
46SOX9_24532713_ChIP-Seq_HFSC_Mouse1.52564970
47KAP1_22055183_ChIP-Seq_ESCs_Mouse1.51927606
48FOXM1_26456572_ChIP-Seq_MCF-7_Human1.51147236
49ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.49762309
50TDRD3_21172665_ChIP-Seq_MCF-7_Human1.49528087
51STAT1_17558387_ChIP-Seq_HELA_Human1.47273154
52GATA3_21867929_ChIP-Seq_CD8_Mouse1.47003653
53SOX2_20726797_ChIP-Seq_SW620_Human1.44413281
54PIAS1_25552417_ChIP-Seq_VCAP_Human1.43833671
55RNF2_27304074_Chip-Seq_NSC_Mouse1.43828484
56WDR5_24793694_ChIP-Seq_LNCAP_Human1.43332579
57CBX2_27304074_Chip-Seq_ESCs_Mouse1.42496142
58* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.42138614
59GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.41725309
60IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.40963476
61CBP_20019798_ChIP-Seq_JUKART_Human1.40963476
62GATA1_19941826_ChIP-Seq_K562_Human1.40759540
63RACK7_27058665_Chip-Seq_MCF-7_Human1.40334694
64RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.39981369
65MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.39522378
66CTNNB1_20460455_ChIP-Seq_HCT116_Human1.38704932
67SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.37841658
68FOXA1_25552417_ChIP-Seq_VCAP_Human1.37231524
69CDX2_20551321_ChIP-Seq_CACO-2_Human1.37038511
70STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.36997963
71SOX2_22085726_ChIP-Seq_NPCs_Mouse1.35541572
72SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.35314244
73TAL1_26923725_Chip-Seq_HPCs_Mouse1.32185776
74ZNF217_24962896_ChIP-Seq_MCF-7_Human1.32038776
75* P68_20966046_ChIP-Seq_HELA_Human1.31697700
76NFE2_27457419_Chip-Seq_LIVER_Mouse1.31598608
77ETV1_20927104_ChIP-Seq_GIST48_Human1.30059258
78FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.29580568
79CTCF_27219007_Chip-Seq_Bcells_Human1.29530252
80PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.28124609
81CREB1_26743006_Chip-Seq_LNCaP_Human1.27051168
82TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24164031
83POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.24164031
84FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.24040306
85MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.23499950
86LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.23395215
87SMRT_27268052_Chip-Seq_Bcells_Human1.23218294
88SUZ12_27294783_Chip-Seq_NPCs_Mouse1.22975463
89PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.22550085
90RUNX1_26923725_Chip-Seq_HPCs_Mouse1.21794873
91KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.20850230
92PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.20803619
93REST_21632747_ChIP-Seq_MESCs_Mouse1.19707026
94SPI1_26923725_Chip-Seq_HPCs_Mouse1.19600470
95NR3C1_21868756_ChIP-Seq_MCF10A_Human1.19236724
96SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.19074910
97PHF8_20622853_ChIP-Seq_HELA_Human1.18914732
98HNFA_21074721_ChIP-Seq_CACO-2_Human1.18729039
99CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.18691529
100CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.18432351
101GATA3_21867929_ChIP-Seq_TH1_Mouse1.16722565
102* CTCF_20526341_ChIP-Seq_ESCs_Human1.16579545
103* PHF8_20622854_ChIP-Seq_HELA_Human1.16506400
104FOXO3_23340844_ChIP-Seq_DLD1_Human1.16103817
105GATA3_24758297_ChIP-Seq_MCF-7_Human1.15511561
106ZNF263_19887448_ChIP-Seq_K562_Human1.14658315
107KDM2B_26808549_Chip-Seq_REH_Human1.14392611
108LXR_22292898_ChIP-Seq_THP-1_Human1.14034579
109TP53_18474530_ChIP-ChIP_U2OS_Human1.13995244
110GATA4_25053715_ChIP-Seq_YYC3_Human1.13747710
111GF1_26923725_Chip-Seq_HPCs_Mouse1.13448533
112RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.12909426
113P53_21459846_ChIP-Seq_SAOS-2_Human1.12314551
114ESET_19884257_ChIP-Seq_ESCs_Mouse1.11405166
115CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.11164353
116TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11097462
117FLI1_21867929_ChIP-Seq_TH2_Mouse1.10912514
118CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09730260
119OCT4_18555785_Chip-Seq_ESCs_Mouse1.08393581
120RBPJ_21746931_ChIP-Seq_IB4_Human1.07622123
121FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.06826403
122TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.06533114
123RAD21_21589869_ChIP-Seq_MESCs_Mouse1.06532412
124PPAR_26484153_Chip-Seq_NCI-H1993_Human1.06103341
125TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.05972077
126FOXA2_19822575_ChIP-Seq_HepG2_Human1.05520810
127RXRA_24833708_ChIP-Seq_LIVER_Mouse1.05014546
128E2F1_20622854_ChIP-Seq_HELA_Human1.02607183
129EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.02485992
130ESRRB_18555785_Chip-Seq_ESCs_Mouse1.01556237
131ERG_20517297_ChIP-Seq_VCAP_Human1.01364845
132HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.00893635
133STAT3_18555785_ChIP-Seq_MESCs_Mouse1.00836351
134KLF4_18555785_Chip-Seq_ESCs_Mouse1.00762382
135PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.00312148
136GATA6_21074721_ChIP-Seq_CACO-2_Human1.00144032
137RARA_24833708_ChIP-Seq_LIVER_Mouse0.99126717
138CBX2_22325352_ChIP-Seq_293T-Rex_Human0.99031490
139GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.98835852
140SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98427062
141TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.98040347
142MYC_27129775_Chip-Seq_CORNEA_Mouse0.97376836
143PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96897912
144SOX2_21211035_ChIP-Seq_LN229_Human0.96871038
145CEBPB_22108803_ChIP-Seq_LS180_Human0.96626412
146CTBP2_25329375_ChIP-Seq_LNCAP_Human0.96494191
147* P300_27268052_Chip-Seq_Bcells_Human0.96479834
148SA1_27219007_Chip-Seq_ERYTHROID_Human0.95739300
149* YY1_22570637_ChIP-Seq_MALME-3M_Human0.95704033
150PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.94880734
151NANOG_18555785_Chip-Seq_ESCs_Mouse0.94327741
152RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94163066
153CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.93975667
154CRX_20693478_ChIP-Seq_RETINA_Mouse0.92996694
155SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.92983293
156P300_18555785_Chip-Seq_ESCs_Mouse0.92807001
157ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.92477369
158CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.92270914
159GATA2_19941826_ChIP-Seq_K562_Human0.92058885
160SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.91762352
161NFYA_21822215_ChIP-Seq_K562_Human0.91470816
162LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.91441642
163SMAD3_21741376_ChIP-Seq_HESCs_Human0.91300913
164TP63_17297297_ChIP-ChIP_HaCaT_Human0.89147414
165CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.89126779
166RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.88934128
167EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.88404555
168OCT4_21477851_ChIP-Seq_ESCs_Mouse0.88293563
169STAT3_18555785_Chip-Seq_ESCs_Mouse0.88125068
170TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.88106734
171NANOG_20526341_ChIP-Seq_ESCs_Human0.87617306
172CMYC_18555785_Chip-Seq_ESCs_Mouse0.87529671
173STAT1_20625510_ChIP-Seq_HELA_Human0.86035015
174P53_22387025_ChIP-Seq_ESCs_Mouse0.85864375
175FLI1_21867929_ChIP-Seq_CD8_Mouse0.85734040
176NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.85196437
177EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.85140302
178* BCOR_27268052_Chip-Seq_Bcells_Human0.85043105
179CTCF_18555785_Chip-Seq_ESCs_Mouse0.84159628
180P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.84136406
181* ELF1_20517297_ChIP-Seq_JURKAT_Human0.83952261
182GATA1_19941827_ChIP-Seq_MEL86_Mouse0.83866823
183SUZ12_18555785_Chip-Seq_ESCs_Mouse0.83858196
184VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.83840526
185CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.82789148

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008875_abnormal_xenobiotic_pharmacok7.02569902
2MP0003698_abnormal_male_reproductive5.85731007
3MP0001929_abnormal_gametogenesis5.33169506
4MP0008877_abnormal_DNA_methylation4.39521569
5MP0002653_abnormal_ependyma_morphology4.13532727
6MP0002277_abnormal_respiratory_mucosa3.95387978
7MP0009780_abnormal_chondrocyte_physiolo3.81835327
8MP0002210_abnormal_sex_determination3.57640967
9MP0008789_abnormal_olfactory_epithelium3.19224158
10MP0002161_abnormal_fertility/fecundity3.16313781
11MP0001145_abnormal_male_reproductive3.07136858
12MP0000566_synostosis2.82647889
13MP0005623_abnormal_meninges_morphology2.64053156
14MP0000653_abnormal_sex_gland2.60946985
15MP0000383_abnormal_hair_follicle2.24175752
16MP0003656_abnormal_erythrocyte_physiolo2.08104818
17MP0010678_abnormal_skin_adnexa2.02771214
18MP0002168_other_aberrant_phenotype2.02066343
19MP0005410_abnormal_fertilization15.0799957
20MP0005083_abnormal_biliary_tract1.99972164
21MP0003011_delayed_dark_adaptation1.99178222
22MP0005670_abnormal_white_adipose1.89443339
23MP0002160_abnormal_reproductive_system1.80993378
24MP0008057_abnormal_DNA_replication1.73152245
25MP0001346_abnormal_lacrimal_gland1.67234818
26MP0010234_abnormal_vibrissa_follicle1.62559658
27MP0002909_abnormal_adrenal_gland1.54659684
28MP0002282_abnormal_trachea_morphology1.45217092
29MP0009046_muscle_twitch1.41626442
30MP0002249_abnormal_larynx_morphology1.40483674
31MP0008058_abnormal_DNA_repair1.38247068
32MP0003646_muscle_fatigue1.37125559
33MP0005165_increased_susceptibility_to1.36319697
34MP0005248_abnormal_Harderian_gland1.35516547
35MP0005395_other_phenotype1.31556710
36MP0009379_abnormal_foot_pigmentation1.31370531
37MP0010155_abnormal_intestine_physiology1.31076198
38MP0010030_abnormal_orbit_morphology1.23220277
39MP0001984_abnormal_olfaction1.18835513
40MP0000465_gastrointestinal_hemorrhage1.14938361
41MP0005647_abnormal_sex_gland1.05174280
42MP0003303_peritoneal_inflammation1.05062482
43MP0001293_anophthalmia0.96625095
44MP0002734_abnormal_mechanical_nocicepti0.96575934
45MP0000681_abnormal_thyroid_gland0.95300337
46MP0002233_abnormal_nose_morphology0.94481187
47MP0002638_abnormal_pupillary_reflex0.93784171
48MP0010094_abnormal_chromosome_stability0.91764704
49MP0001765_abnormal_ion_homeostasis0.91131794
50MP0005408_hypopigmentation0.89852235
51MP0003453_abnormal_keratinocyte_physiol0.89433464
52MP0002876_abnormal_thyroid_physiology0.88908290
53MP0005389_reproductive_system_phenotype0.88373607
54MP0009643_abnormal_urine_homeostasis0.88083148
55MP0005164_abnormal_response_to0.87428449
56MP0005365_abnormal_bile_salt0.85415880
57MP0008995_early_reproductive_senescence0.84674425
58MP0002735_abnormal_chemical_nociception0.82148992
59MP0003950_abnormal_plasma_membrane0.81915291
60MP0002136_abnormal_kidney_physiology0.81851578
61MP0003136_yellow_coat_color0.81090953
62MP0005409_darkened_coat_color0.80340703
63MP0004233_abnormal_muscle_weight0.79245294
64MP0004264_abnormal_extraembryonic_tissu0.77734096
65MP0002098_abnormal_vibrissa_morphology0.75188105
66MP0005220_abnormal_exocrine_pancreas0.74487853
67MP0004883_abnormal_blood_vessel0.73846722
68MP0002139_abnormal_hepatobiliary_system0.73822009
69MP0002405_respiratory_system_inflammati0.73466204
70MP0004133_heterotaxia0.72138627
71MP0005253_abnormal_eye_physiology0.72069610
72MP0005310_abnormal_salivary_gland0.71844936
73MP0000858_altered_metastatic_potential0.69041368
74MP0001485_abnormal_pinna_reflex0.68770494
75MP0005391_vision/eye_phenotype0.67822729
76MP0002928_abnormal_bile_duct0.66869533
77MP0000467_abnormal_esophagus_morphology0.66435789
78MP0003075_altered_response_to0.65844182
79MP0003786_premature_aging0.64825868
80MP0005551_abnormal_eye_electrophysiolog0.64744196
81MP0009765_abnormal_xenobiotic_induced0.63444398
82MP0000358_abnormal_cell_content/0.61547802
83MP0003878_abnormal_ear_physiology0.60599326
84MP0005377_hearing/vestibular/ear_phenot0.60599326
85MP0008007_abnormal_cellular_replicative0.60469001
86MP0001324_abnormal_eye_pigmentation0.60442886
87MP0006035_abnormal_mitochondrial_morpho0.60356764
88MP0001270_distended_abdomen0.60356128
89MP0008961_abnormal_basal_metabolism0.57921818
90MP0002092_abnormal_eye_morphology0.57337797
91MP0009763_increased_sensitivity_to0.57023445
92MP0009703_decreased_birth_body0.57010489
93MP0003866_abnormal_defecation0.56621498
94MP0005085_abnormal_gallbladder_physiolo0.56072466
95MP0005394_taste/olfaction_phenotype0.55193621
96MP0005499_abnormal_olfactory_system0.55193621
97MP0001664_abnormal_digestion0.55071489
98MP0002234_abnormal_pharynx_morphology0.54273721
99MP0006082_CNS_inflammation0.53344723
100MP0005503_abnormal_tendon_morphology0.52672467
101MP0003111_abnormal_nucleus_morphology0.52626502
102MP0005023_abnormal_wound_healing0.51108538
103MP0002116_abnormal_craniofacial_bone0.50947705
104MP0003890_abnormal_embryonic-extraembry0.50910519
105MP0002896_abnormal_bone_mineralization0.49908091
106MP0002133_abnormal_respiratory_system0.49761790
107MP0005388_respiratory_system_phenotype0.49761790
108MP0001790_abnormal_immune_system0.49689000
109MP0005387_immune_system_phenotype0.49689000
110MP0005075_abnormal_melanosome_morpholog0.48411371
111MP0001502_abnormal_circadian_rhythm0.48360585
112MP0002132_abnormal_respiratory_system0.48020310
113MP0003115_abnormal_respiratory_system0.48010325
114MP0003787_abnormal_imprinting0.47884030
115MP0003699_abnormal_female_reproductive0.47675250
116MP0000026_abnormal_inner_ear0.47510190
117MP0001663_abnormal_digestive_system0.46757324
118MP0001944_abnormal_pancreas_morphology0.46561882
119MP0003806_abnormal_nucleotide_metabolis0.44457783
120MP0003191_abnormal_cellular_cholesterol0.43811781
121MP0003861_abnormal_nervous_system0.42251545
122MP0001986_abnormal_taste_sensitivity0.42224026
123MP0001545_abnormal_hematopoietic_system0.42100070
124MP0005397_hematopoietic_system_phenotyp0.42100070
125MP0001299_abnormal_eye_distance/0.41448792
126MP0004043_abnormal_pH_regulation0.41411164
127MP0009115_abnormal_fat_cell0.41299525
128MP0000313_abnormal_cell_death0.40971792
129MP0001672_abnormal_embryogenesis/_devel0.40577893
130MP0005380_embryogenesis_phenotype0.40577893
131MP0005257_abnormal_intraocular_pressure0.40466994
132MP0002135_abnormal_kidney_morphology0.40111562
133MP0001188_hyperpigmentation0.39895317
134MP0001666_abnormal_nutrient_absorption0.39786783
135MP0005636_abnormal_mineral_homeostasis0.39670790
136MP0001119_abnormal_female_reproductive0.39344506
137MP0002822_catalepsy0.38807111
138MP0006292_abnormal_olfactory_placode0.38296456
139MP0002254_reproductive_system_inflammat0.38210215
140MP0000678_abnormal_parathyroid_gland0.37276993
141MP0002084_abnormal_developmental_patter0.36943744
142MP0000569_abnormal_digit_pigmentation0.36468548
143MP0000432_abnormal_head_morphology0.35474498
144MP0006036_abnormal_mitochondrial_physio0.35430204
145MP0001730_embryonic_growth_arrest0.33351874
146MP0005195_abnormal_posterior_eye0.33284034
147MP0002332_abnormal_exercise_endurance0.32544811
148MP0003942_abnormal_urinary_system0.32256439
149MP0003984_embryonic_growth_retardation0.31641487
150MP0002269_muscular_atrophy0.31637916
151MP0002127_abnormal_cardiovascular_syste0.30743144
152MP0009278_abnormal_bone_marrow0.30165926
153MP0002088_abnormal_embryonic_growth/wei0.29995975
154MP0003045_fibrosis0.29816773
155MP0003183_abnormal_peptide_metabolism0.29057644
156MP0005666_abnormal_adipose_tissue0.28994211
157MP0001727_abnormal_embryo_implantation0.28609521
158MP0002085_abnormal_embryonic_tissue0.28293188
159MP0006072_abnormal_retinal_apoptosis0.28254495
160MP0004957_abnormal_blastocyst_morpholog0.27579810
161MP0003077_abnormal_cell_cycle0.26758926
162MP0002114_abnormal_axial_skeleton0.26514784
163MP0000049_abnormal_middle_ear0.26438524
164MP0005266_abnormal_metabolism0.25575927
165MP0002152_abnormal_brain_morphology0.25331843
166MP0004019_abnormal_vitamin_homeostasis0.25308153
167MP0001849_ear_inflammation0.25120308
168MP0002970_abnormal_white_adipose0.24095051
169MP0002752_abnormal_somatic_nervous0.23578396
170MP0000534_abnormal_ureter_morphology0.22769771
171MP0004036_abnormal_muscle_relaxation0.22654340
172MP0002102_abnormal_ear_morphology0.22439160
173MP0002971_abnormal_brown_adipose0.21666989

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.64348839
2Abnormal respiratory motile cilium morphology (HP:0005938)8.60535031
3Abnormal respiratory epithelium morphology (HP:0012253)8.60535031
4Rhinitis (HP:0012384)8.16865294
5Abnormal ciliary motility (HP:0012262)8.08882882
6Chronic bronchitis (HP:0004469)6.93708940
7Nasal polyposis (HP:0100582)6.61122662
8Infertility (HP:0000789)6.11354979
9Abnormality of the nasal mucosa (HP:0000433)5.40740823
10Bronchiectasis (HP:0002110)4.82304809
11Nephronophthisis (HP:0000090)4.57465265
12Bronchitis (HP:0012387)4.52988817
13Male infertility (HP:0003251)3.93946314
14Abnormality of the renal medulla (HP:0100957)3.45180633
15Recurrent sinusitis (HP:0011108)3.34361668
16Recurrent otitis media (HP:0000403)3.27754269
17Abnormality of the lower motor neuron (HP:0002366)3.17046778
18Atelectasis (HP:0100750)3.16408720
19Abnormality of midbrain morphology (HP:0002418)3.13236096
20Molar tooth sign on MRI (HP:0002419)3.13236096
21Chronic otitis media (HP:0000389)3.11048372
22Abnormal spermatogenesis (HP:0008669)2.99420822
23Hyperactive renin-angiotensin system (HP:0000841)2.97521547
24Recurrent bronchitis (HP:0002837)2.92508735
25Tubulointerstitial nephritis (HP:0001970)2.80159326
26Impulsivity (HP:0100710)2.73465403
27Tubular atrophy (HP:0000092)2.66222401
28Medial flaring of the eyebrow (HP:0010747)2.65967053
29Pancreatic cysts (HP:0001737)2.55632208
30Tubulointerstitial abnormality (HP:0001969)2.43387694
31Postaxial foot polydactyly (HP:0001830)2.38603485
32Bile duct proliferation (HP:0001408)2.34741615
33Abnormal biliary tract physiology (HP:0012439)2.34741615
34Gonadotropin excess (HP:0000837)2.29586226
35Congenital hepatic fibrosis (HP:0002612)2.28719274
36Amyotrophic lateral sclerosis (HP:0007354)2.27494589
37Chronic hepatic failure (HP:0100626)2.22743574
38Azoospermia (HP:0000027)2.15579548
39Facial cleft (HP:0002006)2.08748986
40Dyschromatopsia (HP:0007641)2.04706525
41Fibular hypoplasia (HP:0003038)2.04161607
42Tubulointerstitial fibrosis (HP:0005576)2.00541807
43Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.6287097
44Dynein arm defect of respiratory motile cilia (HP:0012255)11.7646134
45Absent/shortened dynein arms (HP:0200106)11.7646134
46Absent frontal sinuses (HP:0002688)1.96383240
47Spastic tetraparesis (HP:0001285)1.94022542
48Stage 5 chronic kidney disease (HP:0003774)1.91876002
49Supernumerary spleens (HP:0009799)1.87614479
50Anencephaly (HP:0002323)1.85994538
51Impaired proprioception (HP:0010831)1.85569992
52Oculomotor apraxia (HP:0000657)1.83998360
53Pancreatic fibrosis (HP:0100732)1.82058928
54Renal salt wasting (HP:0000127)1.79510231
55Short ribs (HP:0000773)1.78989830
56Postaxial hand polydactyly (HP:0001162)1.78071405
57Male pseudohermaphroditism (HP:0000037)1.77329828
58Polydipsia (HP:0001959)1.76684145
59Abnormal drinking behavior (HP:0030082)1.76684145
60Microglossia (HP:0000171)1.76657261
61Abnormal gallbladder physiology (HP:0012438)1.75319438
62Cholecystitis (HP:0001082)1.75319438
63Decreased circulating renin level (HP:0003351)1.74709002
64Abnormality of dentin (HP:0010299)1.74017733
65Asplenia (HP:0001746)1.71835501
66Hypoplasia of the capital femoral epiphysis (HP:0003090)1.71459004
67Nephroblastoma (Wilms tumor) (HP:0002667)1.70454235
68Aplasia/Hypoplasia of the spleen (HP:0010451)1.69566299
69Median cleft lip (HP:0000161)1.68237563
70Chronic sinusitis (HP:0011109)1.62515697
71Abnormality of the renal cortex (HP:0011035)1.62402055
72Renal dysplasia (HP:0000110)1.62128645
73Abnormality of the dental root (HP:0006486)1.61967512
74Taurodontia (HP:0000679)1.61967512
75Abnormality of permanent molar morphology (HP:0011071)1.61967512
76Hyperkalemia (HP:0002153)1.60345977
77Decreased central vision (HP:0007663)1.59474221
78Cystic liver disease (HP:0006706)1.58911859
79Heterotopia (HP:0002282)1.58422352
80Aplasia/Hypoplasia of the tongue (HP:0010295)1.57532501
81Embryonal renal neoplasm (HP:0011794)1.56765988
82J-shaped sella turcica (HP:0002680)1.56732538
83Congenital primary aphakia (HP:0007707)1.55150531
84Gait imbalance (HP:0002141)1.54894379
85Furrowed tongue (HP:0000221)1.53269913
86Upper motor neuron abnormality (HP:0002127)1.51544199
87Sclerocornea (HP:0000647)1.50738106
88Abnormality of molar (HP:0011077)1.50578679
89Abnormality of molar morphology (HP:0011070)1.50578679
90Short thorax (HP:0010306)1.49969775
91True hermaphroditism (HP:0010459)1.49222246
92Abnormality of the dental pulp (HP:0006479)1.44811098
93Bell-shaped thorax (HP:0001591)1.44263128
94Hyperaldosteronism (HP:0000859)1.44224759
95Tongue fasciculations (HP:0001308)1.43636746
96Abnormality of renal excretion (HP:0011036)1.41512391
97Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.41058422
98Hemiparesis (HP:0001269)1.39103310
99Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.36038515
100Hand muscle atrophy (HP:0009130)1.35934772
101Bifid tongue (HP:0010297)1.35870939
102Nephropathy (HP:0000112)1.34951580
103Aplasia/Hypoplasia of the lens (HP:0008063)1.34852275
104Abnormality of chloride homeostasis (HP:0011422)1.34238575
105Absent epiphyses (HP:0010577)1.32567344
106Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.32567344
107Nephrogenic diabetes insipidus (HP:0009806)1.31209325
108Abnormality of the distal phalanges of the toes (HP:0010182)1.30452975
109Deformed sella turcica (HP:0002681)1.30176288
110Abnormality of renin-angiotensin system (HP:0000847)1.30172828
111Occipital encephalocele (HP:0002085)1.27977760
112Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.26789287
113Short nail (HP:0001799)1.25951069
114Muscle fibrillation (HP:0010546)1.25000515
115Choroideremia (HP:0001139)1.24631691
116Glucose intolerance (HP:0000833)1.24421277
117Abnormality of the frontal sinuses (HP:0002687)1.24234961
118Sloping forehead (HP:0000340)1.24030363
119Abnormality of ocular smooth pursuit (HP:0000617)1.22012797
120Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.21540059
121Preaxial hand polydactyly (HP:0001177)1.19717260
122Bilateral microphthalmos (HP:0007633)1.19477171
123Aplasia/Hypoplasia of the fibula (HP:0006492)1.19088026
124Hypokalemic alkalosis (HP:0001949)1.19076504
125Fetal akinesia sequence (HP:0001989)1.18688948
126Genital tract atresia (HP:0001827)1.17544271
127Hyponatremia (HP:0002902)1.16709755
128Absent rod-and cone-mediated responses on ERG (HP:0007688)1.16354394
129Bifid scrotum (HP:0000048)1.15470451
130Cone-rod dystrophy (HP:0000548)1.14202545
131Obstructive sleep apnea (HP:0002870)1.11708446
132Aplasia of the musculature (HP:0100854)1.10842268
133Flat acetabular roof (HP:0003180)1.07652929
134Poor coordination (HP:0002370)1.07480849
135Muscle fiber splitting (HP:0003555)1.04205161
136Short femoral neck (HP:0100864)1.04188280
137Lip pit (HP:0100267)1.04146361
138Popliteal pterygium (HP:0009756)1.03811373
139Vaginal atresia (HP:0000148)1.02866549
140Abnormality of monocarboxylic acid metabolism (HP:0010996)1.01171504
141Distal upper limb amyotrophy (HP:0007149)0.98900385
142Upper limb amyotrophy (HP:0009129)0.98900385
143Spinal muscular atrophy (HP:0007269)0.98358521
144Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)0.93826239

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK37.89507150
2PDK47.89507150
3MST45.42828141
4TESK15.37442165
5PDK25.09306492
6EPHA24.89404418
7PRKD34.39840079
8ICK4.01462473
9WNK42.52725493
10PTK2B2.52656785
11SMG12.45684312
12STK392.42575308
13PNCK2.41089288
14NME12.25218461
15MAPKAPK32.24920795
16MAP3K22.10184291
17STK241.88514951
18NEK21.88218229
19CDK121.83290770
20STK381.79886361
21MAP3K31.68422465
22TYRO31.48268884
23WNK11.48221586
24MAPK151.42675305
25BCR1.31920495
26LRRK21.30954255
27DYRK1B1.27570874
28MST1R1.24662840
29TTK1.23530160
30EPHB11.23184108
31GRK51.16309308
32GRK11.12863122
33TRIB31.03814555
34TLK11.01287690
35MAP3K70.98611978
36TBK10.95604705
37PDK10.93106191
38DYRK30.91313360
39TRPM70.90902208
40CCNB10.83616837
41PRKCI0.83287690
42CHEK20.80246423
43MAP3K120.79530714
44WEE10.78137906
45STK30.77961087
46CAMKK10.77738936
47GRK60.74921177
48EPHA30.68389930
49ADRBK20.65768733
50ERN10.65606907
51CHEK10.63878175
52ERBB20.62616258
53STK38L0.60966507
54CSF1R0.57079208
55IRAK10.56262776
56STK160.55808512
57PASK0.55398949
58MAP2K60.54241923
59ERBB30.52565303
60LMTK20.49448287
61CDC70.48398062
62CAMK1G0.48283897
63NTRK20.48104816
64MARK20.47265405
65PLK10.47187625
66PINK10.46324927
67RPS6KB20.45454894
68STK100.44896101
69CAMK2G0.44130530
70PDPK10.41171345
71PRKG20.41064504
72HIPK20.40624787
73PRKCG0.40537897
74SGK10.39148482
75PAK10.39098681
76ATR0.38681601
77ATM0.38139722
78MTOR0.38036754
79PRKAA20.37722193
80PBK0.37489843
81CDC42BPA0.34623373
82EEF2K0.33735834
83MET0.32988311
84TSSK60.31459141
85IRAK20.30839307
86MAPK70.30792795
87CDK60.30527925
88FGFR30.30276347
89GRK70.30131348
90NEK90.30090694
91MAP2K20.29926998
92PTK60.29058266
93PAK40.29026128
94TGFBR20.28386275
95NLK0.28193928
96TYK20.25854723
97ROCK20.25413172
98PAK20.25207885
99TESK20.24260823
100AKT20.23782049
101PRKAA10.23336384
102LATS10.23120777
103BRSK20.21599475
104MATK0.20181685
105MAP3K100.20121725
106RIPK40.19995069
107FER0.19663427
108ABL10.18378458
109NEK60.17855862
110ROCK10.16646306
111FYN0.15909723
112RET0.15664713
113RPS6KA20.15446042
114DYRK1A0.15349275
115CSK0.15271003
116PRKCA0.15270649
117PRKACA0.14661946
118MAP2K70.14277926
119SRC0.14131943
120CDK70.13494387
121CDK20.12910025
122PRKD20.12571449
123PLK40.12519345
124PRKCZ0.12293821
125AURKA0.12043357
126MAP3K80.11946893
127GSK3B0.11790337
128EGFR0.11717316
129RPS6KB10.11286926
130CDK10.11173758
131ILK0.10331594
132BMPR1B0.10125831
133PIM20.10092824
134MUSK0.09979787
135CDK30.09974892
136MAP3K110.08966083
137PRKDC0.08721144
138PRKACG0.08609330
139PRKCQ0.08562845
140RIPK10.08412416
141ADRBK10.08218253
142MOS0.07750300
143CSNK2A10.07239443
144ZAP700.06970685
145MAP2K40.06577661
146CDK150.06309862
147PDGFRB0.05900333
148MAPKAPK50.05431983
149MAPK80.04635155
150CSNK1E0.04339832
151CDK180.03918733
152PRKG10.03882480
153TAOK10.03711471
154MAP3K40.03560481
155PRKCD0.03462926
156GSK3A0.03354080
157CDK11A0.03111935
158CSNK2A20.02980453
159STK110.02970713
160BRSK10.02945757

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007505.68887716
2Phenylalanine metabolism_Homo sapiens_hsa003605.32089877
3Histidine metabolism_Homo sapiens_hsa003404.82734751
4Tyrosine metabolism_Homo sapiens_hsa003504.04801546
5Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.00082951
6alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.34109920
7Pyruvate metabolism_Homo sapiens_hsa006203.32515151
8Fatty acid biosynthesis_Homo sapiens_hsa000613.29507271
9Linoleic acid metabolism_Homo sapiens_hsa005913.29176819
10beta-Alanine metabolism_Homo sapiens_hsa004103.12774746
11Basal transcription factors_Homo sapiens_hsa030222.62295179
12Propanoate metabolism_Homo sapiens_hsa006402.51301011
13Fanconi anemia pathway_Homo sapiens_hsa034602.51101009
14Pentose phosphate pathway_Homo sapiens_hsa000302.44357015
15Caffeine metabolism_Homo sapiens_hsa002322.38491227
16Dorso-ventral axis formation_Homo sapiens_hsa043202.37190529
17Glucagon signaling pathway_Homo sapiens_hsa049222.35815027
18Fructose and mannose metabolism_Homo sapiens_hsa000512.23541695
19Glycerolipid metabolism_Homo sapiens_hsa005611.85983636
20Selenocompound metabolism_Homo sapiens_hsa004501.84321448
21Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.80569919
22Glycerophospholipid metabolism_Homo sapiens_hsa005641.77212402
23Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.69052007
24Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.67863480
25Huntingtons disease_Homo sapiens_hsa050161.64095742
26Carbohydrate digestion and absorption_Homo sapiens_hsa049731.62539708
27Ether lipid metabolism_Homo sapiens_hsa005651.60850782
28Oocyte meiosis_Homo sapiens_hsa041141.59931517
29PPAR signaling pathway_Homo sapiens_hsa033201.56087877
30mRNA surveillance pathway_Homo sapiens_hsa030151.53326783
31Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.48070100
32Tight junction_Homo sapiens_hsa045301.46327455
33Arachidonic acid metabolism_Homo sapiens_hsa005901.45333420
34Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.42543876
35Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.40840221
36Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.39169738
37RNA transport_Homo sapiens_hsa030131.35247278
38Glycosaminoglycan degradation_Homo sapiens_hsa005311.33563959
39Carbon metabolism_Homo sapiens_hsa012001.26445621
40Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.25955491
41Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.15651767
42Cardiac muscle contraction_Homo sapiens_hsa042601.15464472
43Amphetamine addiction_Homo sapiens_hsa050311.14512794
44Fat digestion and absorption_Homo sapiens_hsa049751.13669906
45Cysteine and methionine metabolism_Homo sapiens_hsa002701.12055467
46Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.11043324
47Peroxisome_Homo sapiens_hsa041461.06894965
48Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.99825245
49Renin secretion_Homo sapiens_hsa049240.97973395
50Renin-angiotensin system_Homo sapiens_hsa046140.93821118
51Mineral absorption_Homo sapiens_hsa049780.92939703
52Chemical carcinogenesis_Homo sapiens_hsa052040.91722925
53Purine metabolism_Homo sapiens_hsa002300.91453776
54Circadian rhythm_Homo sapiens_hsa047100.90924047
55Notch signaling pathway_Homo sapiens_hsa043300.89698251
56Starch and sucrose metabolism_Homo sapiens_hsa005000.88586675
57ABC transporters_Homo sapiens_hsa020100.86553786
58Antigen processing and presentation_Homo sapiens_hsa046120.85599657
59Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.85205855
60Biosynthesis of amino acids_Homo sapiens_hsa012300.84248318
61Fatty acid degradation_Homo sapiens_hsa000710.83080469
62Leukocyte transendothelial migration_Homo sapiens_hsa046700.83026549
63Drug metabolism - other enzymes_Homo sapiens_hsa009830.82995322
64Hepatitis C_Homo sapiens_hsa051600.81606977
65Fatty acid metabolism_Homo sapiens_hsa012120.81572195
66Hedgehog signaling pathway_Homo sapiens_hsa043400.79452290
67Phototransduction_Homo sapiens_hsa047440.77207851
68Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.76050975
69Choline metabolism in cancer_Homo sapiens_hsa052310.76011812
70Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.75000632
71Glutathione metabolism_Homo sapiens_hsa004800.71657221
72Pentose and glucuronate interconversions_Homo sapiens_hsa000400.71593715
73Taste transduction_Homo sapiens_hsa047420.71059249
74Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.70182121
75Adherens junction_Homo sapiens_hsa045200.64137068
76Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.63813941
77Calcium signaling pathway_Homo sapiens_hsa040200.61970512
78Inositol phosphate metabolism_Homo sapiens_hsa005620.59846619
79AMPK signaling pathway_Homo sapiens_hsa041520.56163556
80Adipocytokine signaling pathway_Homo sapiens_hsa049200.55849304
81Central carbon metabolism in cancer_Homo sapiens_hsa052300.55463027
82Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.54707539
83Homologous recombination_Homo sapiens_hsa034400.53920821
84Phosphatidylinositol signaling system_Homo sapiens_hsa040700.53221844
85Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.52909639
86Hematopoietic cell lineage_Homo sapiens_hsa046400.51451476
87Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.48258610
88Estrogen signaling pathway_Homo sapiens_hsa049150.47725731
89Long-term potentiation_Homo sapiens_hsa047200.47612782
90cGMP-PKG signaling pathway_Homo sapiens_hsa040220.47290829
91Retinol metabolism_Homo sapiens_hsa008300.47058661
92RNA degradation_Homo sapiens_hsa030180.46737827
93Bile secretion_Homo sapiens_hsa049760.44871645
94Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.44823950
95Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.43746240
96Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.41664170
97Metabolic pathways_Homo sapiens_hsa011000.41400181
98Transcriptional misregulation in cancer_Homo sapiens_hsa052020.39997661
99Amoebiasis_Homo sapiens_hsa051460.39620553
100Lysosome_Homo sapiens_hsa041420.39269053
101Olfactory transduction_Homo sapiens_hsa047400.38360193
102Vascular smooth muscle contraction_Homo sapiens_hsa042700.36900204
103Endocytosis_Homo sapiens_hsa041440.36052664
104Cyanoamino acid metabolism_Homo sapiens_hsa004600.35959476
105Legionellosis_Homo sapiens_hsa051340.35733457
106Insulin secretion_Homo sapiens_hsa049110.33871709
107Systemic lupus erythematosus_Homo sapiens_hsa053220.33740409
108Protein digestion and absorption_Homo sapiens_hsa049740.31303487
109Lysine degradation_Homo sapiens_hsa003100.29517693
110Thyroid hormone synthesis_Homo sapiens_hsa049180.29251133
111Basal cell carcinoma_Homo sapiens_hsa052170.27056336
112Vitamin digestion and absorption_Homo sapiens_hsa049770.26885391
113Thyroid hormone signaling pathway_Homo sapiens_hsa049190.25917721
114VEGF signaling pathway_Homo sapiens_hsa043700.25331847
115Cocaine addiction_Homo sapiens_hsa050300.24763558
116Collecting duct acid secretion_Homo sapiens_hsa049660.24674512
117Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.24652593
118Sphingolipid signaling pathway_Homo sapiens_hsa040710.24579810
119Insulin resistance_Homo sapiens_hsa049310.23739076
120Primary bile acid biosynthesis_Homo sapiens_hsa001200.23097493
121Ovarian steroidogenesis_Homo sapiens_hsa049130.22632306
122Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.22354913
123Arginine and proline metabolism_Homo sapiens_hsa003300.22133795
124Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.21964629
125Galactose metabolism_Homo sapiens_hsa000520.21711040
126Jak-STAT signaling pathway_Homo sapiens_hsa046300.21632250
127cAMP signaling pathway_Homo sapiens_hsa040240.21425836
128Wnt signaling pathway_Homo sapiens_hsa043100.21107062
129Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.21031433
130Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.18215221
131Hippo signaling pathway_Homo sapiens_hsa043900.17771277
132Cell cycle_Homo sapiens_hsa041100.17618536
133Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.17488709
134RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.17145406
135Type I diabetes mellitus_Homo sapiens_hsa049400.16189098
136Pyrimidine metabolism_Homo sapiens_hsa002400.15624972
137Phagosome_Homo sapiens_hsa041450.15450735
138Glutamatergic synapse_Homo sapiens_hsa047240.14705625
139Sphingolipid metabolism_Homo sapiens_hsa006000.14403471
140Prostate cancer_Homo sapiens_hsa052150.13883283
141Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.12850454
142Allograft rejection_Homo sapiens_hsa053300.12399232
143Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.11833568
144Complement and coagulation cascades_Homo sapiens_hsa046100.11753538
145Salivary secretion_Homo sapiens_hsa049700.11600664
146Autoimmune thyroid disease_Homo sapiens_hsa053200.11571570
147Viral carcinogenesis_Homo sapiens_hsa052030.11415939
148Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.11309555
149Steroid hormone biosynthesis_Homo sapiens_hsa001400.10966878
150Vibrio cholerae infection_Homo sapiens_hsa051100.10298652
151Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.09501788
152Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.09394794
153Pancreatic secretion_Homo sapiens_hsa049720.08794340
154Serotonergic synapse_Homo sapiens_hsa047260.07373716
155N-Glycan biosynthesis_Homo sapiens_hsa005100.05206355
156Graft-versus-host disease_Homo sapiens_hsa053320.04982185
157Apoptosis_Homo sapiens_hsa042100.04764474
158Dilated cardiomyopathy_Homo sapiens_hsa054140.04023249
159Nicotine addiction_Homo sapiens_hsa050330.03631821
160Melanogenesis_Homo sapiens_hsa049160.03249208

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