LRRC47

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1heterochromatin organization (GO:0070828)5.32073487
2pre-miRNA processing (GO:0031054)5.26835886
3DNA unwinding involved in DNA replication (GO:0006268)4.88334620
4protein localization to kinetochore (GO:0034501)4.81237258
5nuclear pore complex assembly (GO:0051292)4.78502324
6nuclear pore organization (GO:0006999)4.59723714
7histone arginine methylation (GO:0034969)4.15390672
8L-serine metabolic process (GO:0006563)4.12148219
9protein localization to chromosome, centromeric region (GO:0071459)4.08441051
10intracellular estrogen receptor signaling pathway (GO:0030520)4.05028862
11regulation of translational termination (GO:0006449)4.03709278
12regulation of translational fidelity (GO:0006450)4.03638269
13mitotic nuclear envelope disassembly (GO:0007077)4.03537445
14chromatin assembly (GO:0031497)4.00959148
15negative regulation of histone methylation (GO:0031061)4.00722889
16mRNA stabilization (GO:0048255)4.00160622
17RNA stabilization (GO:0043489)4.00160622
18mitotic sister chromatid cohesion (GO:0007064)3.95726135
19folic acid-containing compound biosynthetic process (GO:0009396)3.93335524
20regulation of RNA export from nucleus (GO:0046831)3.93123159
21ribosomal small subunit biogenesis (GO:0042274)3.90876315
22creatine metabolic process (GO:0006600)3.90611360
23mitotic chromosome condensation (GO:0007076)3.89611771
24nuclear envelope disassembly (GO:0051081)3.85148049
25membrane disassembly (GO:0030397)3.85148049
26mitotic sister chromatid segregation (GO:0000070)3.80158179
27DNA replication-dependent nucleosome organization (GO:0034723)3.77420693
28DNA replication-dependent nucleosome assembly (GO:0006335)3.77420693
29proline biosynthetic process (GO:0006561)3.76536422
30sister chromatid segregation (GO:0000819)3.69699719
31DNA duplex unwinding (GO:0032508)3.59944087
32negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.58470021
33DNA geometric change (GO:0032392)3.54479183
34NLS-bearing protein import into nucleus (GO:0006607)3.52607146
35pore complex assembly (GO:0046931)3.52503183
36trophectodermal cell differentiation (GO:0001829)3.51737515
37histone H2A monoubiquitination (GO:0035518)3.50720748
38regulation of gene silencing by RNA (GO:0060966)3.50455070
39regulation of posttranscriptional gene silencing (GO:0060147)3.50455070
40regulation of gene silencing by miRNA (GO:0060964)3.50455070
41peptidyl-lysine dimethylation (GO:0018027)3.46857579
42monoubiquitinated protein deubiquitination (GO:0035520)3.44821011
43formation of translation preinitiation complex (GO:0001731)3.43997050
44regulation of hippo signaling (GO:0035330)3.40568417
45maternal placenta development (GO:0001893)3.39713599
46regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.39294068
47histone H4-K12 acetylation (GO:0043983)3.37613865
48glucocorticoid receptor signaling pathway (GO:0042921)3.34325636
49DNA strand renaturation (GO:0000733)3.31758418
50regulation of histone H3-K9 methylation (GO:0051570)3.31013598
51nuclear envelope organization (GO:0006998)3.28954434
52regulation of nucleobase-containing compound transport (GO:0032239)3.27043135
53chromatin silencing (GO:0006342)3.25694594
54cellular protein complex localization (GO:0034629)3.24164828
553-UTR-mediated mRNA stabilization (GO:0070935)3.23680734
56actin-myosin filament sliding (GO:0033275)3.22858084
57muscle filament sliding (GO:0030049)3.22858084
58positive regulation of gene expression, epigenetic (GO:0045815)3.21460583
59negative regulation of mRNA metabolic process (GO:1903312)3.21171948
60gene silencing (GO:0016458)3.17425964
61viral transcription (GO:0019083)3.16741026
62positive regulation of chromosome segregation (GO:0051984)3.16680782
63sarcoplasmic reticulum calcium ion transport (GO:0070296)3.16206646
64negative regulation of cell size (GO:0045792)3.15356837
65NADH metabolic process (GO:0006734)3.15249495
66positive regulation of histone deacetylation (GO:0031065)3.12047536
67protein insertion into membrane (GO:0051205)3.11616319
68positive regulation of synapse maturation (GO:0090129)3.11509520
69regulation of sister chromatid cohesion (GO:0007063)3.10956437
70regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.10200976
71gene silencing by RNA (GO:0031047)3.08471238
72regulation of mRNA stability (GO:0043488)3.07985326
73peptidyl-arginine omega-N-methylation (GO:0035247)3.07933671
74negative regulation of RNA splicing (GO:0033119)3.05095355
75negative regulation of mRNA processing (GO:0050686)3.04755305
76positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling3.03219928
77establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.02970460
78mitochondrion transport along microtubule (GO:0047497)3.02970460
79negative regulation of gene expression, epigenetic (GO:0045814)3.02363017
80nuclear envelope reassembly (GO:0031468)2.98798865
81mitotic nuclear envelope reassembly (GO:0007084)2.98798865
82regulation of mammary gland epithelial cell proliferation (GO:0033599)2.98367642
83mitotic G1 DNA damage checkpoint (GO:0031571)2.98169689
84regulation of spindle organization (GO:0090224)2.98064768
85negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.97994053
86planar cell polarity pathway involved in neural tube closure (GO:0090179)2.95646688
87regulation of translational elongation (GO:0006448)2.94139784
88protein localization to chromosome (GO:0034502)2.92882998
89gluconeogenesis (GO:0006094)2.92856245
90chromatin assembly or disassembly (GO:0006333)2.92614904
91establishment of mitochondrion localization (GO:0051654)2.92317327
92spliceosomal tri-snRNP complex assembly (GO:0000244)2.92219063
93translational termination (GO:0006415)2.92041567
94regulation of RNA stability (GO:0043487)2.90309785
95cytoplasmic mRNA processing body assembly (GO:0033962)2.89737560
96oxidative phosphorylation (GO:0006119)2.87561746
97ribonucleoprotein complex biogenesis (GO:0022613)2.87536416
98histone H4-K5 acetylation (GO:0043981)2.87417995
99histone H4-K8 acetylation (GO:0043982)2.87417995
100rRNA transcription (GO:0009303)2.87326407
101histone H4-K16 acetylation (GO:0043984)2.85995477
102ribosome biogenesis (GO:0042254)2.85443179
103protein complex localization (GO:0031503)2.84583639
104peptidyl-arginine methylation (GO:0018216)2.83360441
105peptidyl-arginine N-methylation (GO:0035246)2.83360441
106IMP biosynthetic process (GO:0006188)2.82022173
107positive regulation of SMAD protein import into nucleus (GO:0060391)2.81487155
108negative regulation of gene silencing (GO:0060969)2.80996118
109nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.79551685
110DNA conformation change (GO:0071103)2.79392175
111DNA replication checkpoint (GO:0000076)2.79333866
112mitotic metaphase plate congression (GO:0007080)2.79330256
113protein-DNA complex disassembly (GO:0032986)2.79001088
114nucleosome disassembly (GO:0006337)2.79001088
115mitochondrial fusion (GO:0008053)2.78761523
116translational elongation (GO:0006414)2.78740172
1172-oxoglutarate metabolic process (GO:0006103)2.77936280
118regulation of synapse maturation (GO:0090128)2.77676142
119apoptotic process involved in morphogenesis (GO:0060561)2.76408896
120chromosome condensation (GO:0030261)2.76141524
121corticosteroid receptor signaling pathway (GO:0031958)2.75402263
122respiratory system process (GO:0003016)2.73461269
123regulation of mitochondrial translation (GO:0070129)2.73000088
124mitotic G1/S transition checkpoint (GO:0044819)2.72086580
125regulation of mitotic spindle organization (GO:0060236)2.72063689
126DNA replication initiation (GO:0006270)2.71121347
127hexose biosynthetic process (GO:0019319)2.69076045
128alternative mRNA splicing, via spliceosome (GO:0000380)2.68894848
129dosage compensation (GO:0007549)2.67589192
130monosaccharide biosynthetic process (GO:0046364)2.65121360
131positive regulation of cell cycle G2/M phase transition (GO:1902751)2.64551911
132positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)2.64551911
133negative regulation of catenin import into nucleus (GO:0035414)2.64414915
134convergent extension (GO:0060026)2.63887600
135mRNA transport (GO:0051028)2.63601671
136regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.63484037
137cell migration in hindbrain (GO:0021535)2.62568078
138IMP metabolic process (GO:0046040)2.61526969
139establishment of integrated proviral latency (GO:0075713)2.61115085
140nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.60818321
141DNA strand elongation involved in DNA replication (GO:0006271)2.59500332
142regulation of gene silencing (GO:0060968)2.58928603
143proline metabolic process (GO:0006560)2.58848773
144regulation of telomere maintenance via telomerase (GO:0032210)2.58525715
145muscle cell fate commitment (GO:0042693)2.57847260
146negative regulation of histone modification (GO:0031057)2.56456628
147negative regulation of microtubule polymerization (GO:0031115)2.55075635
148protein maturation by protein folding (GO:0022417)2.53329359
149ribosomal small subunit assembly (GO:0000028)2.52848480
150mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.52048504
151transcription from mitochondrial promoter (GO:0006390)2.51820550
152regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.50397737
153skeletal muscle fiber development (GO:0048741)2.50034378
154DNA strand elongation (GO:0022616)2.49729969
155oxaloacetate metabolic process (GO:0006107)2.49069382
156regulation of NFAT protein import into nucleus (GO:0051532)2.48250839
157regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 2.48185397
158serine family amino acid biosynthetic process (GO:0009070)2.48077380
159protein complex disassembly (GO:0043241)2.42255332
160skeletal muscle contraction (GO:0003009)2.41910505
161tricarboxylic acid cycle (GO:0006099)2.39850599
162negative regulation of DNA-templated transcription, elongation (GO:0032785)2.39254771
163translational initiation (GO:0006413)2.38753872
164maturation of SSU-rRNA (GO:0030490)2.37538305
165tRNA methylation (GO:0030488)2.36619060
166protein targeting to mitochondrion (GO:0006626)2.34018680
167viral life cycle (GO:0019058)2.33953861
168cellular protein complex disassembly (GO:0043624)2.31962500
169ribosomal large subunit biogenesis (GO:0042273)2.29347337
170positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling2.28639492
171regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 2.28639492
172actin-mediated cell contraction (GO:0070252)2.28065175
173macromolecular complex disassembly (GO:0032984)2.26066359
174cerebellar Purkinje cell layer development (GO:0021680)2.24963857
175determination of adult lifespan (GO:0008340)2.24531919
176sarcomere organization (GO:0045214)2.24456720

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.77855663
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.56898652
3MYC_22102868_ChIP-Seq_BL_Human3.73497177
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.36562380
5HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.26764450
6EGR1_19374776_ChIP-ChIP_THP-1_Human3.14904715
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.88479531
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.81974786
9MYC_18555785_ChIP-Seq_MESCs_Mouse2.54897310
10THAP11_20581084_ChIP-Seq_MESCs_Mouse2.46533350
11E2F4_17652178_ChIP-ChIP_JURKAT_Human2.43195156
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.34847235
13MYC_19079543_ChIP-ChIP_MESCs_Mouse2.15115400
14VDR_21846776_ChIP-Seq_THP-1_Human2.11218568
15TCF7_22412390_ChIP-Seq_EML_Mouse2.02063479
16* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.00773744
17* KDM2B_26808549_Chip-Seq_DND41_Human1.97156414
18* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.94405265
19ERG_21242973_ChIP-ChIP_JURKAT_Human1.90504321
20NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.86593419
21KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.86029397
22AR_21909140_ChIP-Seq_LNCAP_Human1.85294167
23THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.78757968
24* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.78607919
25CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.78306702
26STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.77200316
27STAT6_21828071_ChIP-Seq_BEAS2B_Human1.74206344
28SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.72860879
29PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.72708556
30TET1_21451524_ChIP-Seq_MESCs_Mouse1.71189655
31* ELK3_25401928_ChIP-Seq_HUVEC_Human1.69416011
32KDM2B_26808549_Chip-Seq_SUP-B15_Human1.67499260
33POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.66000977
34CIITA_25753668_ChIP-Seq_RAJI_Human1.65204419
35DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.64531053
36E2F1_21310950_ChIP-Seq_MCF-7_Human1.64309400
37* ETS1_20019798_ChIP-Seq_JURKAT_Human1.63907152
38KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.63812260
39TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.62394182
40ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.62086683
41MYC_19030024_ChIP-ChIP_MESCs_Mouse1.61088737
42* KDM5A_27292631_Chip-Seq_BREAST_Human1.60939051
43YY1_21170310_ChIP-Seq_MESCs_Mouse1.60616931
44ZFP281_18757296_ChIP-ChIP_E14_Mouse1.60341018
45ZNF263_19887448_ChIP-Seq_K562_Human1.59660472
46ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.55741212
47SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.48458102
48UTX_26944678_Chip-Seq_JUKART_Human1.47416960
49KLF4_18555785_ChIP-Seq_MESCs_Mouse1.46760016
50ZFP281_27345836_Chip-Seq_ESCs_Mouse1.44096906
51KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.43760112
52KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.43760112
53KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.43760112
54ATF3_27146783_Chip-Seq_COLON_Human1.42690608
55CREB1_15753290_ChIP-ChIP_HEK293T_Human1.42235816
56* XRN2_22483619_ChIP-Seq_HELA_Human1.41389237
57E2F1_18555785_ChIP-Seq_MESCs_Mouse1.39864634
58STAT3_1855785_ChIP-Seq_MESCs_Mouse1.39763124
59SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.37948202
60ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.37481897
61MYC_18358816_ChIP-ChIP_MESCs_Mouse1.37359458
62MYCN_18555785_ChIP-Seq_MESCs_Mouse1.36989379
63SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.36555440
64* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.36383902
65EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.35726387
66* SA1_27219007_Chip-Seq_ERYTHROID_Human1.35695145
67* RACK7_27058665_Chip-Seq_MCF-7_Human1.35381497
68CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.34130511
69TTF2_22483619_ChIP-Seq_HELA_Human1.33415354
70SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.33114387
71* CTCF_27219007_Chip-Seq_Bcells_Human1.33024395
72SRY_22984422_ChIP-ChIP_TESTIS_Rat1.32607481
73CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.31601197
74* MAF_26560356_Chip-Seq_TH1_Human1.29549626
75MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.29482917
76P300_27058665_Chip-Seq_ZR-75-30cells_Human1.29350001
77TP63_19390658_ChIP-ChIP_HaCaT_Human1.28704580
78SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.28430612
79* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.27935829
80CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.27841530
81DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.27821998
82* NCOR1_26117541_ChIP-Seq_K562_Human1.27145181
83FOXP1_21924763_ChIP-Seq_HESCs_Human1.25760951
84CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.25545718
85KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.25330331
86BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.24876997
87LXR_22292898_ChIP-Seq_THP-1_Human1.24757672
88NANOG_21062744_ChIP-ChIP_HESCs_Human1.24698265
89KDM2B_26808549_Chip-Seq_JURKAT_Human1.23835561
90NELFA_20434984_ChIP-Seq_ESCs_Mouse1.22918091
91* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.22793325
92KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.21690037
93* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.21518307
94DCP1A_22483619_ChIP-Seq_HELA_Human1.20671371
95* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.19157843
96NANOG_18555785_ChIP-Seq_MESCs_Mouse1.19099986
97OCT4_18692474_ChIP-Seq_MEFs_Mouse1.17873464
98* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.16790906
99PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.16083605
100CTCF_18555785_ChIP-Seq_MESCs_Mouse1.15150656
101* CHD1_26751641_Chip-Seq_LNCaP_Human1.14817496
102* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.14510961
103* SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.13910168
104TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.13631274
105YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.12776496
106MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.12692440
107NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.12654865
108* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.11796108
109SMC4_20622854_ChIP-Seq_HELA_Human1.10887140
110POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.10839725
111SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.10155846
112DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.09951204
113HIF1A_21447827_ChIP-Seq_MCF-7_Human1.09772456
114CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.09041299
115MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.08659216
116KDM2B_26808549_Chip-Seq_K562_Human1.08523761
117E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.07956340
118DNAJC2_21179169_ChIP-ChIP_NT2_Human1.07599618
119TFEB_21752829_ChIP-Seq_HELA_Human1.07577024
120NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.07254481
121ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.06420096
122* CREB1_26743006_Chip-Seq_LNCaP_Human1.06311465
123TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.06304734
124* P68_20966046_ChIP-Seq_HELA_Human1.06080456
125RARG_19884340_ChIP-ChIP_MEFs_Mouse1.06065934
126* GABP_19822575_ChIP-Seq_HepG2_Human1.06009641
127RARB_27405468_Chip-Seq_BRAIN_Mouse1.03838818
128SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.03294615
129TCF3_18692474_ChIP-Seq_MEFs_Mouse1.03243975
130TBX5_21415370_ChIP-Seq_HL-1_Mouse1.01558115
131E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.01398605
132RARA_24833708_ChIP-Seq_LIVER_Mouse1.00650788
133NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.98975776
134* MAF_26560356_Chip-Seq_TH2_Human0.98322117
135TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.97944954
136* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.97928026
137PKCTHETA_26484144_Chip-Seq_BREAST_Human0.97591910
138FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.96492540
139* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.96375241
140MYB_26560356_Chip-Seq_TH1_Human0.95841656
141* TP53_22127205_ChIP-Seq_IMR90_Human0.95286266
142RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.95157635
143* ELF1_20517297_ChIP-Seq_JURKAT_Human0.95120277
144* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.94478237
145GATA6_25053715_ChIP-Seq_YYC3_Human0.93248348
146TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.92837248
147SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.92056700
148MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.91735568
149TCF3_18692474_ChIP-Seq_MESCs_Mouse0.91519453
150BRD4_27068464_Chip-Seq_AML-cells_Mouse0.88372968

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog3.93002532
2MP0003111_abnormal_nucleus_morphology3.20806967
3MP0004957_abnormal_blastocyst_morpholog3.18065381
4MP0010352_gastrointestinal_tract_polyps3.17874048
5MP0005076_abnormal_cell_differentiation2.96221237
6MP0000751_myopathy2.94702528
7MP0003646_muscle_fatigue2.94269948
8MP0003693_abnormal_embryo_hatching2.90685172
9MP0005451_abnormal_body_composition2.81122182
10MP0003077_abnormal_cell_cycle2.73432599
11MP0001730_embryonic_growth_arrest2.72158710
12MP0004145_abnormal_muscle_electrophysio2.67997441
13MP0004859_abnormal_synaptic_plasticity2.49189694
14MP0010094_abnormal_chromosome_stability2.46180793
15MP0008057_abnormal_DNA_replication2.34550988
16MP0009379_abnormal_foot_pigmentation2.27666750
17MP0001849_ear_inflammation2.27220682
18MP0002822_catalepsy2.24346719
19MP0000350_abnormal_cell_proliferation2.21766781
20MP0002396_abnormal_hematopoietic_system2.20179873
21MP0001672_abnormal_embryogenesis/_devel2.20039881
22MP0005380_embryogenesis_phenotype2.20039881
23MP0004185_abnormal_adipocyte_glucose2.18910466
24MP0003984_embryonic_growth_retardation2.14138381
25MP0002088_abnormal_embryonic_growth/wei2.11689830
26MP0000749_muscle_degeneration2.10485466
27MP0003123_paternal_imprinting2.04475245
28MP0002084_abnormal_developmental_patter2.02790424
29MP0003890_abnormal_embryonic-extraembry2.00187906
30MP0010307_abnormal_tumor_latency1.95734487
31MP0000759_abnormal_skeletal_muscle1.91558912
32MP0004197_abnormal_fetal_growth/weight/1.91357186
33MP0001697_abnormal_embryo_size1.90906000
34MP0002086_abnormal_extraembryonic_tissu1.90743512
35MP0005423_abnormal_somatic_nervous1.90155301
36MP0001188_hyperpigmentation1.87922059
37MP0002085_abnormal_embryonic_tissue1.86430054
38MP0003315_abnormal_perineum_morphology1.83270203
39MP0004270_analgesia1.83200728
40MP0004264_abnormal_extraembryonic_tissu1.77738332
41MP0002653_abnormal_ependyma_morphology1.73863611
42MP0002080_prenatal_lethality1.73182597
43MP0009278_abnormal_bone_marrow1.65951666
44MP0009672_abnormal_birth_weight1.62402368
45MP0002106_abnormal_muscle_physiology1.59752529
46MP0008877_abnormal_DNA_methylation1.56258028
47MP0008961_abnormal_basal_metabolism1.55927296
48MP0000733_abnormal_muscle_development1.49511410
49MP0000537_abnormal_urethra_morphology1.48848156
50MP0006036_abnormal_mitochondrial_physio1.46134169
51MP0003300_gastrointestinal_ulcer1.43934544
52MP0002877_abnormal_melanocyte_morpholog1.43422020
53MP0003566_abnormal_cell_adhesion1.42545725
54MP0001661_extended_life_span1.40436050
55MP0004036_abnormal_muscle_relaxation1.37987208
56MP0003303_peritoneal_inflammation1.34112482
57MP0004808_abnormal_hematopoietic_stem1.32770510
58MP0009703_decreased_birth_body1.31171838
59MP0010234_abnormal_vibrissa_follicle1.30717557
60MP0003119_abnormal_digestive_system1.29915952
61MP0008007_abnormal_cellular_replicative1.29652460
62MP0003121_genomic_imprinting1.26598829
63MP0009053_abnormal_anal_canal1.24907304
64MP0001293_anophthalmia1.24891230
65MP0005330_cardiomyopathy1.24650248
66MP0005397_hematopoietic_system_phenotyp1.22276215
67MP0001545_abnormal_hematopoietic_system1.22276215
68MP0004233_abnormal_muscle_weight1.21687584
69MP0000428_abnormal_craniofacial_morphol1.21175139
70MP0005369_muscle_phenotype1.20544538
71MP0008770_decreased_survivor_rate1.20119010
72MP0000678_abnormal_parathyroid_gland1.18048669
73MP0000313_abnormal_cell_death1.16762845
74MP0002249_abnormal_larynx_morphology1.16645757
75MP0001346_abnormal_lacrimal_gland1.15666722
76MP0002019_abnormal_tumor_incidence1.15489850
77MP0003567_abnormal_fetal_cardiomyocyte1.14874923
78MP0003941_abnormal_skin_development1.14765100
79MP0008932_abnormal_embryonic_tissue1.13906687
80MP0002925_abnormal_cardiovascular_devel1.12162822
81MP0001915_intracranial_hemorrhage1.09654540
82MP0002332_abnormal_exercise_endurance1.08823157
83MP0003329_amyloid_beta_deposits1.08287160
84MP0006035_abnormal_mitochondrial_morpho1.06901596
85MP0002092_abnormal_eye_morphology1.06345999
86MP0000490_abnormal_crypts_of1.06004575
87MP0003635_abnormal_synaptic_transmissio1.05651131
88MP0002796_impaired_skin_barrier1.04882744
89MP0005501_abnormal_skin_physiology1.03962665
90MP0003942_abnormal_urinary_system1.03819126
91MP0000703_abnormal_thymus_morphology1.03808934
92MP0002697_abnormal_eye_size1.03217929
93MP0005023_abnormal_wound_healing1.02833250
94MP0004130_abnormal_muscle_cell1.01943767
95MP0003385_abnormal_body_wall1.01209555
96MP0005623_abnormal_meninges_morphology1.01126715
97MP0005257_abnormal_intraocular_pressure1.00724369
98MP0003879_abnormal_hair_cell1.00043092
99MP0003122_maternal_imprinting0.99873931
100MP0000049_abnormal_middle_ear0.99513045
101MP0010630_abnormal_cardiac_muscle0.98923499
102MP0005666_abnormal_adipose_tissue0.96977412
103MP0003221_abnormal_cardiomyocyte_apopto0.96678223
104MP0004858_abnormal_nervous_system0.96636635
105MP0001529_abnormal_vocalization0.96395004
106MP0010030_abnormal_orbit_morphology0.95872398
107MP0000955_abnormal_spinal_cord0.95329742
108MP0005499_abnormal_olfactory_system0.95051530
109MP0005394_taste/olfaction_phenotype0.95051530
110MP0000266_abnormal_heart_morphology0.93992462
111MP0002269_muscular_atrophy0.93008202
112MP0009840_abnormal_foam_cell0.92881553
113MP0004811_abnormal_neuron_physiology0.88759567
114MP0000750_abnormal_muscle_regeneration0.87986343
115MP0005621_abnormal_cell_physiology0.87778928
116MP0000003_abnormal_adipose_tissue0.87605473
117MP0000566_synostosis0.86837223
118MP0003115_abnormal_respiratory_system0.85039080
119MP0004087_abnormal_muscle_fiber0.84120422
120MP0003935_abnormal_craniofacial_develop0.84054848
121MP0004133_heterotaxia0.83207921
122MP0002970_abnormal_white_adipose0.82715315
123MP0000747_muscle_weakness0.82410833
124MP0005375_adipose_tissue_phenotype0.82402317
125MP0003137_abnormal_impulse_conducting0.81565682
126MP0002152_abnormal_brain_morphology0.81470191
127MP0000778_abnormal_nervous_system0.80760635
128MP0005384_cellular_phenotype0.79515833
129MP0008058_abnormal_DNA_repair0.79323328
130MP0005620_abnormal_muscle_contractility0.78792813
131MP0001348_abnormal_lacrimal_gland0.77278739
132MP0002398_abnormal_bone_marrow0.77025778
133MP0000462_abnormal_digestive_system0.76213109
134MP0002063_abnormal_learning/memory/cond0.76106210
135MP0001727_abnormal_embryo_implantation0.75419411
136MP0002734_abnormal_mechanical_nocicepti0.74936672
137MP0002081_perinatal_lethality0.74482867
138MP0001784_abnormal_fluid_regulation0.74224828
139MP0002184_abnormal_innervation0.73710646
140MP0002089_abnormal_postnatal_growth/wei0.73202896
141MP0002114_abnormal_axial_skeleton0.72842699
142MP0002722_abnormal_immune_system0.72202725
143MP0001145_abnormal_male_reproductive0.71655177
144MP0000432_abnormal_head_morphology0.71050580
145MP0003861_abnormal_nervous_system0.70573615
146MP0003763_abnormal_thymus_physiology0.67302447
147MP0005187_abnormal_penis_morphology0.65762494
148MP0004084_abnormal_cardiac_muscle0.64831104
149MP0000477_abnormal_intestine_morphology0.63893882
150MP0000358_abnormal_cell_content/0.63557172
151MP0009333_abnormal_splenocyte_physiolog0.62176277
152MP0002111_abnormal_tail_morphology0.61030357
153MP0002210_abnormal_sex_determination0.60882531
154MP0000689_abnormal_spleen_morphology0.59428595
155MP0003172_abnormal_lysosome_physiology0.58775836

Predicted human phenotypes

RankGene SetZ-score
1Nemaline bodies (HP:0003798)5.27161412
2Muscle fiber inclusion bodies (HP:0100299)5.26529014
3Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)5.16416749
4Myopathic facies (HP:0002058)4.56025072
5Exercise-induced myalgia (HP:0003738)4.11445620
6Centrally nucleated skeletal muscle fibers (HP:0003687)4.07101679
7Ependymoma (HP:0002888)3.87463365
8Type 1 muscle fiber predominance (HP:0003803)3.85835681
9Exercise-induced muscle cramps (HP:0003710)3.52753564
10Progressive muscle weakness (HP:0003323)3.49412883
11Abnormality of the lower motor neuron (HP:0002366)3.25752490
12Hyperacusis (HP:0010780)3.14675648
13Calcaneovalgus deformity (HP:0001848)3.11636794
14Ragged-red muscle fibers (HP:0003200)3.11039015
15Abnormality of the astrocytes (HP:0100707)3.06289417
16Astrocytoma (HP:0009592)3.06289417
17Rhabdomyolysis (HP:0003201)2.95962894
18Multiple enchondromatosis (HP:0005701)2.94799115
19Distal lower limb amyotrophy (HP:0008944)2.92995446
20Myokymia (HP:0002411)2.90528674
21Neoplasm of striated muscle (HP:0009728)2.86031577
22Increased nuchal translucency (HP:0010880)2.83514611
23Abnormality of skeletal muscle fiber size (HP:0012084)2.75658642
24EMG: myopathic abnormalities (HP:0003458)2.74916415
25Aplasia/Hypoplasia of the sacrum (HP:0008517)2.73340512
26Rhabdomyosarcoma (HP:0002859)2.61682649
27Myoglobinuria (HP:0002913)2.60849867
28Abnormality of the fingertips (HP:0001211)2.59146233
29Truncus arteriosus (HP:0001660)2.59140391
30Genu recurvatum (HP:0002816)2.58220607
31Lower limb amyotrophy (HP:0007210)2.58172111
32Muscle stiffness (HP:0003552)2.53249693
33Achilles tendon contracture (HP:0001771)2.50690583
34Hand muscle atrophy (HP:0009130)2.50611793
35Ulnar bowing (HP:0003031)2.48548389
36Renal duplication (HP:0000075)2.45413947
37Cerebral aneurysm (HP:0004944)2.45117099
38Deformed tarsal bones (HP:0008119)2.44837106
39Upper limb amyotrophy (HP:0009129)2.44363221
40Distal upper limb amyotrophy (HP:0007149)2.44363221
41Distal lower limb muscle weakness (HP:0009053)2.43311341
42Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.39212776
43Short 4th metacarpal (HP:0010044)2.39212776
44Medulloblastoma (HP:0002885)2.38611303
45Abnormality of the calcaneus (HP:0008364)2.38063690
46Increased variability in muscle fiber diameter (HP:0003557)2.35459213
47Prominent nose (HP:0000448)2.35019843
48Rimmed vacuoles (HP:0003805)2.34448813
49Long eyelashes (HP:0000527)2.34265863
50Rectal prolapse (HP:0002035)2.33355682
51Glioma (HP:0009733)2.33141002
52Distal arthrogryposis (HP:0005684)2.32735384
53Stridor (HP:0010307)2.30917403
54Abnormality of the Achilles tendon (HP:0005109)2.30511243
55Volvulus (HP:0002580)2.27378591
56Insomnia (HP:0100785)2.24549324
57Overlapping toe (HP:0001845)2.24202458
58Deviation of the thumb (HP:0009603)2.23904853
59Proximal placement of thumb (HP:0009623)2.22037261
60Neoplasm of the oral cavity (HP:0100649)2.22023634
61Skin tags (HP:0010609)2.21752698
62Pseudobulbar signs (HP:0002200)2.21459393
63Basal cell carcinoma (HP:0002671)2.20821871
64Macroorchidism (HP:0000053)2.20003636
65Heterotopia (HP:0002282)2.19408027
66Angiofibromas (HP:0010615)2.18527539
67Adenoma sebaceum (HP:0009720)2.18527539
68Increased muscle lipid content (HP:0009058)2.16195449
69Broad palm (HP:0001169)2.14851063
70Rib fusion (HP:0000902)2.13425346
71Bulbar palsy (HP:0001283)2.11272208
72Increased intramyocellular lipid droplets (HP:0012240)2.10855943
73Neoplasm of the heart (HP:0100544)2.10417418
74Urethral obstruction (HP:0000796)2.09895934
75Lymphangioma (HP:0100764)2.08164738
76Shallow orbits (HP:0000586)2.06026819
77Hyperthyroidism (HP:0000836)2.03994879
78Selective tooth agenesis (HP:0001592)2.03696583
79Atrioventricular block (HP:0001678)2.03608618
80Fibroma (HP:0010614)2.03208663
81Ankle clonus (HP:0011448)2.02321113
82Ulnar deviation of the wrist (HP:0003049)2.01931679
83Muscle hypertrophy of the lower extremities (HP:0008968)2.01205358
84Muscle fiber atrophy (HP:0100295)2.00784988
85Hyporeflexia of lower limbs (HP:0002600)1.99610438
86Long palpebral fissure (HP:0000637)1.98494554
87Elfin facies (HP:0004428)1.98247588
88Round ear (HP:0100830)1.97979430
89Broad thumb (HP:0011304)1.97398746
90Preauricular skin tag (HP:0000384)1.96838888
91Malignant gastrointestinal tract tumors (HP:0006749)1.96432421
92Gastrointestinal carcinoma (HP:0002672)1.96432421
93Fibrous tissue neoplasm (HP:0012316)1.95694059
94Atresia of the external auditory canal (HP:0000413)1.95584254
95Abnormality of the 4th metacarpal (HP:0010012)1.95118546
96Overriding aorta (HP:0002623)1.94459616
97Renovascular hypertension (HP:0100817)1.94215406
98Shawl scrotum (HP:0000049)1.93560857
99Exercise intolerance (HP:0003546)1.93492164
100Trismus (HP:0000211)1.93462661
101Back pain (HP:0003418)1.93197490
102Broad distal phalanx of finger (HP:0009836)1.91776526
103Vertebral arch anomaly (HP:0008438)1.90365069
104Bowel incontinence (HP:0002607)1.90138326
105Facial hemangioma (HP:0000329)1.89908622
106Myotonia (HP:0002486)1.88568711
107Generalized muscle weakness (HP:0003324)1.86806259
108Difficulty climbing stairs (HP:0003551)1.86165134
109Dysphonia (HP:0001618)1.85478194
110Neck muscle weakness (HP:0000467)1.85344935
111Turricephaly (HP:0000262)1.84308323
112Abnormality of cells of the erythroid lineage (HP:0012130)1.82946852
113Cafe-au-lait spot (HP:0000957)1.82399101
114Pelvic girdle muscle weakness (HP:0003749)1.81043634
115Abnormal large intestine physiology (HP:0012700)1.80574441
116Abnormal atrioventricular conduction (HP:0005150)1.79985091
117Heart block (HP:0012722)1.79907928
118Calf muscle hypertrophy (HP:0008981)1.79861504
119Vertebral clefting (HP:0008428)1.79755701
120Reduced subcutaneous adipose tissue (HP:0003758)1.79340430
121Colon cancer (HP:0003003)1.79169768
122Areflexia of lower limbs (HP:0002522)1.79077162
123Metatarsus adductus (HP:0001840)1.78565378
124Spinal rigidity (HP:0003306)1.78013799
125Abnormality of the calf musculature (HP:0001430)1.77697021
126Mildly elevated creatine phosphokinase (HP:0008180)1.77550000
127Double outlet right ventricle (HP:0001719)1.76495213
128Congenital malformation of the right heart (HP:0011723)1.76495213
129Short humerus (HP:0005792)1.76160688
130Mitral valve prolapse (HP:0001634)1.76069176
131Microvesicular hepatic steatosis (HP:0001414)1.75463804
132High pitched voice (HP:0001620)1.75392088
133Difficulty running (HP:0009046)1.74860649
134Dysmetric saccades (HP:0000641)1.73212062
135Progressive external ophthalmoplegia (HP:0000590)1.72616633
136Male infertility (HP:0003251)1.72598543
137Aneurysm (HP:0002617)1.72229317
138Adducted thumb (HP:0001181)1.71236549
139Scapular winging (HP:0003691)1.70489861
140Amyotrophic lateral sclerosis (HP:0007354)1.70251998
141Hypopigmentation of the fundus (HP:0007894)1.69916272
142Subaortic stenosis (HP:0001682)1.69815864
143Abnormality of the left ventricular outflow tract (HP:0011103)1.69815864
144Transposition of the great arteries (HP:0001669)1.69538063
145Abnormal connection of the cardiac segments (HP:0011545)1.69538063
146Abnormal ventriculo-arterial connection (HP:0011563)1.69538063
147Reticulocytosis (HP:0001923)1.69091459
148Muscle fiber splitting (HP:0003555)1.69071975
149Short 5th finger (HP:0009237)1.68907050
150Hypoplastic left heart (HP:0004383)1.68612233
151Respiratory difficulties (HP:0002880)1.68106340
152Reticulocytopenia (HP:0001896)1.67919196
153Hallux valgus (HP:0001822)1.67680564
154Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.67504402
155Decreased activity of mitochondrial respiratory chain (HP:0008972)1.67504402
156Vertebral fusion (HP:0002948)1.66971259
157Abnormality of the labia minora (HP:0012880)1.65919340
158Sensory axonal neuropathy (HP:0003390)1.65777199
159Foot dorsiflexor weakness (HP:0009027)1.65140513
160Disproportionate tall stature (HP:0001519)1.64488050
161Ventricular tachycardia (HP:0004756)1.63744325
162Peripheral hypomyelination (HP:0007182)1.63327926
163Missing ribs (HP:0000921)1.63008011
164Spastic diplegia (HP:0001264)1.62980035
165Bilateral microphthalmos (HP:0007633)1.62907249
166Megalocornea (HP:0000485)1.62478107
167Cortical dysplasia (HP:0002539)1.62369024
168Pointed chin (HP:0000307)1.62160686
169Testicular atrophy (HP:0000029)1.61614255
170Aplasia/hypoplasia of the humerus (HP:0006507)1.61364933
171Attention deficit hyperactivity disorder (HP:0007018)1.60892440
172Abnormality of the foot musculature (HP:0001436)1.60421472
173Deviation of the hallux (HP:0010051)1.60008891
174Global brain atrophy (HP:0002283)1.59855070
175Spina bifida occulta (HP:0003298)1.59644502
176External ophthalmoplegia (HP:0000544)1.59614717
177EMG: neuropathic changes (HP:0003445)1.59459166
178Increased density of long bones (HP:0006392)1.59181254
179Increased connective tissue (HP:0009025)1.58857599
180Self-mutilation (HP:0000742)1.58798217
181Large earlobe (HP:0009748)1.58251506
182Sandal gap (HP:0001852)1.58250480
183Impulsivity (HP:0100710)1.58048015
184Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.57627155
185Short phalanx of the thumb (HP:0009660)1.57325894
186Abnormal gallbladder physiology (HP:0012438)1.56835039
187Cholecystitis (HP:0001082)1.56835039
188Intestinal polyp (HP:0005266)1.56059588

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK125.24755040
2SMG14.47109093
3TRIB34.09863384
4PKN23.50602932
5EEF2K3.38560533
6CDC73.03700317
7MAP3K103.03402597
8OBSCN2.61168406
9NME22.54844264
10PHKG22.48770383
11PHKG12.48770383
12VRK22.42551390
13NEK22.37167357
14LATS12.34896269
15ICK2.01048912
16STK101.99843780
17TAOK11.86008758
18ALK1.84656074
19LATS21.82467551
20ARAF1.72933567
21IRAK31.70153706
22ERN11.68417094
23TTK1.64661433
24TYRO31.57186067
25NEK11.55060237
26CDK41.47812273
27MTOR1.44080449
28GRK61.41114706
29MAP4K11.40926216
30TAF11.40349888
31PRKD31.37994045
32NME11.35815028
33PRPF4B1.34400227
34CDK71.33158190
35STK161.29658981
36SIK11.28946702
37BRAF1.23869742
38LRRK21.17022776
39PIM21.15128226
40MAP3K81.14947349
41SCYL21.13752500
42STK31.12723960
43PAK41.11607809
44PTK61.11384091
45CHEK11.09348773
46CDK61.05553121
47NTRK11.04857554
48PDGFRA1.03201069
49RIPK11.02861053
50MAP2K41.00556851
51BRD40.99934209
52WEE10.96254384
53RPS6KB20.95958916
54CHEK20.94609967
55BMX0.94580583
56RPS6KA40.94220666
57BCKDK0.92979022
58DYRK20.92650797
59DMPK0.90705492
60CDK190.89604110
61MARK10.89068189
62SRPK10.88154601
63TTN0.87976065
64DYRK1B0.87616939
65MOS0.87420236
66FLT30.86940040
67SIK20.85283590
68CAMK1D0.83313072
69MAPK120.82911295
70CDK20.82903968
71BUB10.81980791
72MAP3K10.81821006
73MAP2K70.80178587
74MAP2K20.77911312
75MAP2K30.77104539
76LMTK20.76167289
77PAK20.75928315
78MELK0.74479725
79PLK10.73964766
80ATR0.73664220
81DAPK30.73604797
82CDK11A0.71152478
83CDK150.69716011
84HIPK20.68888481
85CDK140.68446723
86EPHA20.68354777
87ATM0.66578290
88TAOK20.66147040
89TESK20.65910356
90CSF1R0.65557724
91KSR20.65384014
92MAP3K90.64713605
93CAMK1G0.64318855
94MAP3K110.64115330
95RET0.63948678
96AURKB0.62898171
97CDK180.61265571
98CSNK1E0.58910503
99PDGFRB0.58672737
100PTK20.57967645
101RPS6KA20.57171842
102MARK30.56573417
103DAPK10.56002334
104MARK20.55590078
105STK40.55413444
106AKT20.55322593
107MAP3K70.54930316
108FGFR10.54715918
109RPS6KL10.54029676
110RPS6KC10.54029676
111MAP3K60.53541526
112BRSK10.53491567
113NTRK20.51653171
114IRAK20.50132857
115CSNK1G30.49956279
116CSNK1D0.49678490
117ZAP700.49553643
118CSNK1G20.49459334
119CDK10.49351748
120ABL20.49195667
121PASK0.48936758
122FGFR40.48693973
123PRKAA10.48149411
124STK380.46463885
125RPS6KA10.46259902
126TSSK60.45288816
127PIM10.45098046
128CLK10.44856388
129ILK0.42269216
130EIF2AK20.42205827
131STK38L0.41782735
132PAK60.41248373
133MAPK110.40829155
134BRSK20.40375658
135DYRK30.39397830
136MAPK140.37535164
137PAK10.37347788
138MAPK100.35912428
139AURKA0.35369804
140PRKCH0.33443130
141CDK90.33101349
142GSK3B0.32898538
143WNK10.32877992
144STK110.31114916
145MAPK10.30588834
146PRKDC0.30386204
147CAMK40.27734857

Predicted pathways (KEGG)

RankGene SetZ-score
1RNA transport_Homo sapiens_hsa030132.74314525
2Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.66499286
3Ribosome_Homo sapiens_hsa030102.55145262
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.47674397
5DNA replication_Homo sapiens_hsa030302.40194308
6mRNA surveillance pathway_Homo sapiens_hsa030152.23116095
7Cell cycle_Homo sapiens_hsa041102.21321411
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.12527098
9mTOR signaling pathway_Homo sapiens_hsa041502.11263527
10Spliceosome_Homo sapiens_hsa030402.08695683
11Nitrogen metabolism_Homo sapiens_hsa009101.96141261
12Chronic myeloid leukemia_Homo sapiens_hsa052201.88324054
13Arginine and proline metabolism_Homo sapiens_hsa003301.83667224
14Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.77387702
15One carbon pool by folate_Homo sapiens_hsa006701.73165573
16Selenocompound metabolism_Homo sapiens_hsa004501.68125249
17Mismatch repair_Homo sapiens_hsa034301.66956880
18Cardiac muscle contraction_Homo sapiens_hsa042601.65610462
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.64718250
20Lysine degradation_Homo sapiens_hsa003101.60940273
21Thyroid cancer_Homo sapiens_hsa052161.52398425
22Non-small cell lung cancer_Homo sapiens_hsa052231.51814319
23Pyruvate metabolism_Homo sapiens_hsa006201.50590363
24MicroRNAs in cancer_Homo sapiens_hsa052061.47573563
25Central carbon metabolism in cancer_Homo sapiens_hsa052301.41019002
26Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.39427272
27Acute myeloid leukemia_Homo sapiens_hsa052211.31224233
28Colorectal cancer_Homo sapiens_hsa052101.30668383
29Thyroid hormone signaling pathway_Homo sapiens_hsa049191.30482480
30Small cell lung cancer_Homo sapiens_hsa052221.28871958
31Folate biosynthesis_Homo sapiens_hsa007901.24920938
32Bladder cancer_Homo sapiens_hsa052191.24040452
33Base excision repair_Homo sapiens_hsa034101.23858741
34Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.23408991
35Parkinsons disease_Homo sapiens_hsa050121.22242434
36Pancreatic cancer_Homo sapiens_hsa052121.21924651
37Notch signaling pathway_Homo sapiens_hsa043301.19639178
38Adherens junction_Homo sapiens_hsa045201.19621832
39Renal cell carcinoma_Homo sapiens_hsa052111.18695011
40Fructose and mannose metabolism_Homo sapiens_hsa000511.18360870
41Biosynthesis of amino acids_Homo sapiens_hsa012301.17718444
42Endometrial cancer_Homo sapiens_hsa052131.17340627
43Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.16915356
44VEGF signaling pathway_Homo sapiens_hsa043701.14985846
45Dilated cardiomyopathy_Homo sapiens_hsa054141.12968191
46Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.12830030
47RNA polymerase_Homo sapiens_hsa030201.12545830
48Oocyte meiosis_Homo sapiens_hsa041141.12160831
49Viral carcinogenesis_Homo sapiens_hsa052031.11179519
50Hippo signaling pathway_Homo sapiens_hsa043901.10520103
51Glioma_Homo sapiens_hsa052141.10201608
52Longevity regulating pathway - mammal_Homo sapiens_hsa042111.09880522
53Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.09254155
54HTLV-I infection_Homo sapiens_hsa051661.08378136
55Pyrimidine metabolism_Homo sapiens_hsa002401.08360059
56Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.06292015
57Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.05349952
58Neurotrophin signaling pathway_Homo sapiens_hsa047221.02920728
59p53 signaling pathway_Homo sapiens_hsa041151.02734409
60AMPK signaling pathway_Homo sapiens_hsa041521.02238455
61Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.01505329
62Proteoglycans in cancer_Homo sapiens_hsa052051.01239312
63Huntingtons disease_Homo sapiens_hsa050160.99371456
64Synaptic vesicle cycle_Homo sapiens_hsa047210.99130331
65Insulin resistance_Homo sapiens_hsa049310.99075409
662-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.98813341
67Galactose metabolism_Homo sapiens_hsa000520.97607858
68Vitamin B6 metabolism_Homo sapiens_hsa007500.97603744
69Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.96790829
70Cyanoamino acid metabolism_Homo sapiens_hsa004600.96267646
71Alzheimers disease_Homo sapiens_hsa050100.94308248
72Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.94097620
73Oxidative phosphorylation_Homo sapiens_hsa001900.93565175
74Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.92387416
75Dorso-ventral axis formation_Homo sapiens_hsa043200.92110090
76RNA degradation_Homo sapiens_hsa030180.90976342
77B cell receptor signaling pathway_Homo sapiens_hsa046620.89449458
78Prostate cancer_Homo sapiens_hsa052150.87972465
79Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.85841820
80Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.85690599
81Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.83882067
82Basal cell carcinoma_Homo sapiens_hsa052170.83727680
83Cysteine and methionine metabolism_Homo sapiens_hsa002700.81845951
84Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.80892920
85Insulin signaling pathway_Homo sapiens_hsa049100.79955238
86Estrogen signaling pathway_Homo sapiens_hsa049150.79299445
87Phenylalanine metabolism_Homo sapiens_hsa003600.79006318
88Long-term potentiation_Homo sapiens_hsa047200.73868728
89Prolactin signaling pathway_Homo sapiens_hsa049170.72334914
90TGF-beta signaling pathway_Homo sapiens_hsa043500.72278573
91Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.71952521
92HIF-1 signaling pathway_Homo sapiens_hsa040660.71818687
93Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.71122537
94Regulation of actin cytoskeleton_Homo sapiens_hsa048100.70453753
95Herpes simplex infection_Homo sapiens_hsa051680.70068747
96Transcriptional misregulation in cancer_Homo sapiens_hsa052020.69369476
97Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.69020368
98T cell receptor signaling pathway_Homo sapiens_hsa046600.68853422
99Viral myocarditis_Homo sapiens_hsa054160.68283090
100Antigen processing and presentation_Homo sapiens_hsa046120.68219670
101Epstein-Barr virus infection_Homo sapiens_hsa051690.68092959
102Pathways in cancer_Homo sapiens_hsa052000.67956412
103Glucagon signaling pathway_Homo sapiens_hsa049220.67881291
104Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.67875372
105Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.65049376
106Pentose phosphate pathway_Homo sapiens_hsa000300.64991964
107Adipocytokine signaling pathway_Homo sapiens_hsa049200.64754155
108Focal adhesion_Homo sapiens_hsa045100.64460889
109Hepatitis B_Homo sapiens_hsa051610.64320676
110Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.64151380
111Tight junction_Homo sapiens_hsa045300.63755707
112Nucleotide excision repair_Homo sapiens_hsa034200.63586642
113Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.62256938
114Alcoholism_Homo sapiens_hsa050340.61739748
115Leukocyte transendothelial migration_Homo sapiens_hsa046700.61456373
116Carbon metabolism_Homo sapiens_hsa012000.60887987
117Hedgehog signaling pathway_Homo sapiens_hsa043400.60852361
118FoxO signaling pathway_Homo sapiens_hsa040680.60817758
119Apoptosis_Homo sapiens_hsa042100.59931869
120AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.59578746
121ErbB signaling pathway_Homo sapiens_hsa040120.58314532
122Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.58028040
123Homologous recombination_Homo sapiens_hsa034400.57793076
124Fatty acid elongation_Homo sapiens_hsa000620.56981632
125Wnt signaling pathway_Homo sapiens_hsa043100.56451726
126Purine metabolism_Homo sapiens_hsa002300.55918575
127Vibrio cholerae infection_Homo sapiens_hsa051100.53726393
128Arginine biosynthesis_Homo sapiens_hsa002200.53436081
129Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.52031050
130Endocytosis_Homo sapiens_hsa041440.51886053
131Type II diabetes mellitus_Homo sapiens_hsa049300.51529082
132Fatty acid metabolism_Homo sapiens_hsa012120.48902652
133Inositol phosphate metabolism_Homo sapiens_hsa005620.48418882
134Prion diseases_Homo sapiens_hsa050200.48360250
135Melanogenesis_Homo sapiens_hsa049160.47771091
136Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.46905414
137Rap1 signaling pathway_Homo sapiens_hsa040150.46494084
138Basal transcription factors_Homo sapiens_hsa030220.45677312
139Sulfur relay system_Homo sapiens_hsa041220.44473431
140Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.44374953
141MAPK signaling pathway_Homo sapiens_hsa040100.44101957
142Phospholipase D signaling pathway_Homo sapiens_hsa040720.43642758
143Toxoplasmosis_Homo sapiens_hsa051450.43027454
144beta-Alanine metabolism_Homo sapiens_hsa004100.40731577
145Metabolic pathways_Homo sapiens_hsa011000.39838974
146Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.39484472
147Oxytocin signaling pathway_Homo sapiens_hsa049210.38641897
148GnRH signaling pathway_Homo sapiens_hsa049120.37900867

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