LRRC49

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.38364957
2synaptic vesicle maturation (GO:0016188)5.35968563
3synaptic vesicle exocytosis (GO:0016079)5.31989770
4glutamate secretion (GO:0014047)5.03846712
5regulation of synaptic vesicle exocytosis (GO:2000300)5.01763030
6pyrimidine nucleobase catabolic process (GO:0006208)4.99449995
7positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.95842075
8neuronal action potential propagation (GO:0019227)4.81201643
9locomotory exploration behavior (GO:0035641)4.79207191
10synaptic vesicle docking involved in exocytosis (GO:0016081)4.78605786
11protein localization to synapse (GO:0035418)4.76931526
12regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.73088141
13positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.71588056
14vocalization behavior (GO:0071625)4.68717215
15neuron cell-cell adhesion (GO:0007158)4.50021620
16regulation of synaptic vesicle transport (GO:1902803)4.35340592
17neurotransmitter secretion (GO:0007269)4.30217477
18regulation of glutamate receptor signaling pathway (GO:1900449)4.28537913
19behavioral response to nicotine (GO:0035095)4.24991125
20nucleobase catabolic process (GO:0046113)4.13016938
21neurofilament cytoskeleton organization (GO:0060052)4.08939373
22ionotropic glutamate receptor signaling pathway (GO:0035235)3.99724617
23cerebellar Purkinje cell differentiation (GO:0021702)3.97874160
24cell migration in hindbrain (GO:0021535)3.97048665
25epithelial cilium movement (GO:0003351)3.95730116
26exploration behavior (GO:0035640)3.91622049
27epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.89716808
28regulation of synapse structural plasticity (GO:0051823)3.88956995
29regulation of neuronal synaptic plasticity (GO:0048168)3.83105328
30regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.81495313
31neural tube formation (GO:0001841)3.80754083
32proline transport (GO:0015824)3.78663473
33synaptic transmission, glutamatergic (GO:0035249)3.73028935
34negative regulation of dendrite morphogenesis (GO:0050774)3.71882021
35cilium movement (GO:0003341)3.67993474
36membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.65900307
37regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.64795566
38positive regulation of synaptic transmission, GABAergic (GO:0032230)3.63451285
39neuron-neuron synaptic transmission (GO:0007270)3.62998016
40layer formation in cerebral cortex (GO:0021819)3.62595921
41negative regulation of microtubule polymerization (GO:0031115)3.60839097
42glutamate receptor signaling pathway (GO:0007215)3.60637779
43regulation of long-term neuronal synaptic plasticity (GO:0048169)3.60567141
44neurotransmitter-gated ion channel clustering (GO:0072578)3.56208710
45membrane depolarization during action potential (GO:0086010)3.50301834
46neuromuscular process controlling posture (GO:0050884)3.45885171
47innervation (GO:0060384)3.45151948
48regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.42910554
49postsynaptic membrane organization (GO:0001941)3.42592015
50neurotransmitter transport (GO:0006836)3.40837337
51axonemal dynein complex assembly (GO:0070286)3.38528606
52limb bud formation (GO:0060174)3.38326065
53central nervous system projection neuron axonogenesis (GO:0021952)3.37508849
54gamma-aminobutyric acid transport (GO:0015812)3.36660838
55negative regulation of dendrite development (GO:2000171)3.35879346
56cellular potassium ion homeostasis (GO:0030007)3.35196801
57synaptic vesicle endocytosis (GO:0048488)3.35150083
58regulation of neurotransmitter secretion (GO:0046928)3.31996136
59activation of protein kinase A activity (GO:0034199)3.30933747
60neuron recognition (GO:0008038)3.30429138
61positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.29042139
62cilium or flagellum-dependent cell motility (GO:0001539)3.28248682
63neuromuscular process controlling balance (GO:0050885)3.27451610
64regulation of cilium movement (GO:0003352)3.26369211
65positive regulation of membrane potential (GO:0045838)3.24664097
66intraciliary transport (GO:0042073)3.24295508
67protein localization to cilium (GO:0061512)3.24217655
68regulation of excitatory postsynaptic membrane potential (GO:0060079)3.23494763
69regulation of neurotransmitter levels (GO:0001505)3.23321247
70positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.20819846
71calcium ion-dependent exocytosis (GO:0017156)3.16549261
72axon cargo transport (GO:0008088)3.16235422
73vesicle transport along microtubule (GO:0047496)3.16198253
74regulation of synaptic transmission, glutamatergic (GO:0051966)3.15493327
75axonal fasciculation (GO:0007413)3.13794739
76presynaptic membrane assembly (GO:0097105)3.13321355
77regulation of postsynaptic membrane potential (GO:0060078)3.13201502
78cell communication by electrical coupling (GO:0010644)3.12758220
79response to auditory stimulus (GO:0010996)3.12460967
80cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.11861224
81dendrite morphogenesis (GO:0048813)3.09781790
82nonmotile primary cilium assembly (GO:0035058)3.09596703
83negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.09256974
84positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.08750413
85positive regulation of synapse maturation (GO:0090129)3.08713713
86regulation of neurotransmitter transport (GO:0051588)3.08713686
87regulation of vesicle fusion (GO:0031338)3.08216447
88membrane hyperpolarization (GO:0060081)3.05489247
89synapse assembly (GO:0007416)3.05386864
90membrane depolarization (GO:0051899)3.04543980
91presynaptic membrane organization (GO:0097090)3.04161959
92regulation of synaptic plasticity (GO:0048167)3.03190464
93dendritic spine morphogenesis (GO:0060997)3.01955429
94response to pheromone (GO:0019236)3.01955134
95regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.01916738
96retinal cone cell development (GO:0046549)3.01835611
97central nervous system neuron axonogenesis (GO:0021955)3.01316515
98axoneme assembly (GO:0035082)3.01155888
99neuromuscular process (GO:0050905)2.98335371
100cilium morphogenesis (GO:0060271)2.98178076
101negative regulation of synaptic transmission, GABAergic (GO:0032229)2.97852480
102organelle transport along microtubule (GO:0072384)2.96861134
103behavioral response to ethanol (GO:0048149)2.96187889
104prepulse inhibition (GO:0060134)2.95022565
105sodium ion export (GO:0071436)2.95004899
106long-term memory (GO:0007616)2.94212890
107auditory behavior (GO:0031223)2.94161092
108transmission of nerve impulse (GO:0019226)2.92492518
109retinal ganglion cell axon guidance (GO:0031290)2.92484056
110long-term synaptic potentiation (GO:0060291)2.91540544
111cilium organization (GO:0044782)2.90504123
112glycine transport (GO:0015816)2.89233185
113positive regulation of potassium ion transmembrane transport (GO:1901381)2.88816113
114synaptic transmission (GO:0007268)2.88604119
115protein polyglutamylation (GO:0018095)2.88321606
116positive regulation of neurotransmitter transport (GO:0051590)2.88043815
117gamma-aminobutyric acid signaling pathway (GO:0007214)2.87946586
118regulation of voltage-gated calcium channel activity (GO:1901385)2.86438235
119G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.86291493
120cilium assembly (GO:0042384)2.85034354
121neuronal ion channel clustering (GO:0045161)2.77680117
122neuronal action potential (GO:0019228)2.77383006
123regulation of collateral sprouting (GO:0048670)2.77154971
124regulation of synaptic transmission, GABAergic (GO:0032228)2.76885124
125adult walking behavior (GO:0007628)2.76704646
126sex differentiation (GO:0007548)2.75805288
127cerebral cortex radially oriented cell migration (GO:0021799)2.75431296
128somite development (GO:0061053)2.75269630
129head development (GO:0060322)2.72640794
130cornea development in camera-type eye (GO:0061303)2.70313045
131kynurenine metabolic process (GO:0070189)2.68798931
132fucose catabolic process (GO:0019317)2.65643887
133L-fucose metabolic process (GO:0042354)2.65643887
134L-fucose catabolic process (GO:0042355)2.65643887
135regulation of action potential (GO:0098900)2.65417106
136inner ear receptor stereocilium organization (GO:0060122)2.65150635
137spinal cord development (GO:0021510)2.64486117
138calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.64206347
139startle response (GO:0001964)2.63616027
140sympathetic nervous system development (GO:0048485)2.62572276
141negative regulation of multicellular organism growth (GO:0040015)2.62349100
142synaptic transmission, cholinergic (GO:0007271)2.60515285
143detection of light stimulus involved in visual perception (GO:0050908)2.58519329
144detection of light stimulus involved in sensory perception (GO:0050962)2.58519329
145olfactory bulb development (GO:0021772)2.58283652
146negative regulation of cytosolic calcium ion concentration (GO:0051481)2.55872325
147detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.55299968
148mechanosensory behavior (GO:0007638)2.52559703
149kidney morphogenesis (GO:0060993)2.49626769
150tryptophan catabolic process (GO:0006569)2.49607736
151indole-containing compound catabolic process (GO:0042436)2.49607736
152indolalkylamine catabolic process (GO:0046218)2.49607736
153regulation of microtubule-based movement (GO:0060632)2.49091493
154positive regulation of synapse assembly (GO:0051965)2.46507139
155spinal cord motor neuron differentiation (GO:0021522)2.46170405
156water-soluble vitamin biosynthetic process (GO:0042364)2.43899753
157positive regulation of mitochondrial fission (GO:0090141)2.42465173
158photoreceptor cell development (GO:0042461)2.40432014
159limb development (GO:0060173)2.40386917
160appendage development (GO:0048736)2.40386917
161negative regulation of telomere maintenance (GO:0032205)2.40242371
162somite rostral/caudal axis specification (GO:0032525)2.38293474
163DNA double-strand break processing (GO:0000729)2.37805891
164glycosphingolipid biosynthetic process (GO:0006688)2.37517174
165indolalkylamine metabolic process (GO:0006586)2.35510826
166short-term memory (GO:0007614)2.35391070
167cellular component assembly involved in morphogenesis (GO:0010927)2.34075017

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.84888276
2GBX2_23144817_ChIP-Seq_PC3_Human3.63667700
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.09455714
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.97401629
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.92706115
6VDR_22108803_ChIP-Seq_LS180_Human2.80241839
7REST_21632747_ChIP-Seq_MESCs_Mouse2.78200787
8HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.71242249
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.62326097
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.60851461
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.60851461
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.50812910
13EZH2_27304074_Chip-Seq_ESCs_Mouse2.48403802
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.47993477
15SALL1_21062744_ChIP-ChIP_HESCs_Human2.47762504
16SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.47356936
17SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.43687013
18MTF2_20144788_ChIP-Seq_MESCs_Mouse2.41114416
19NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.32702431
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.29215473
21SUZ12_27294783_Chip-Seq_ESCs_Mouse2.26032234
22REST_18959480_ChIP-ChIP_MESCs_Mouse2.24126203
23RARB_27405468_Chip-Seq_BRAIN_Mouse2.23541643
24EED_16625203_ChIP-ChIP_MESCs_Mouse2.23192257
25FUS_26573619_Chip-Seq_HEK293_Human2.21492535
26GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.15779297
27RNF2_27304074_Chip-Seq_ESCs_Mouse2.14708003
28DROSHA_22980978_ChIP-Seq_HELA_Human2.12249043
29AR_21572438_ChIP-Seq_LNCaP_Human2.03516915
30CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.02413370
31TAF15_26573619_Chip-Seq_HEK293_Human2.00598101
32EWS_26573619_Chip-Seq_HEK293_Human1.89898136
33IKZF1_21737484_ChIP-ChIP_HCT116_Human1.88235976
34CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.86168612
35CTBP2_25329375_ChIP-Seq_LNCAP_Human1.82963872
36EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.75540499
37SMAD4_21799915_ChIP-Seq_A2780_Human1.72255497
38BMI1_23680149_ChIP-Seq_NPCS_Mouse1.70738340
39FLI1_27457419_Chip-Seq_LIVER_Mouse1.64608885
40SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.59958128
41PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.59332738
42BCAT_22108803_ChIP-Seq_LS180_Human1.58447719
43* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.54130202
44ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.52687207
45MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.52429636
46ZFP57_27257070_Chip-Seq_ESCs_Mouse1.49896959
47P300_19829295_ChIP-Seq_ESCs_Human1.48693915
48NR3C1_23031785_ChIP-Seq_PC12_Mouse1.48302242
49IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.47893468
50CBP_20019798_ChIP-Seq_JUKART_Human1.47893468
51PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.47499903
52RNF2_27304074_Chip-Seq_NSC_Mouse1.46747108
53CTBP1_25329375_ChIP-Seq_LNCAP_Human1.46735563
54RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.46564455
55CBX2_27304074_Chip-Seq_ESCs_Mouse1.45316709
56TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.44882421
57MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.40558791
58HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.39708435
59* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36764033
60PCGF2_27294783_Chip-Seq_ESCs_Mouse1.33355979
61TOP2B_26459242_ChIP-Seq_MCF-7_Human1.33002203
62RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.32685786
63IGF1R_20145208_ChIP-Seq_DFB_Human1.32353736
64ZNF274_21170338_ChIP-Seq_K562_Hela1.31299299
65AR_25329375_ChIP-Seq_VCAP_Human1.30143053
66MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.29558192
67SOX2_21211035_ChIP-Seq_LN229_Gbm1.27980302
68GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27107904
69SMAD3_21741376_ChIP-Seq_EPCs_Human1.26561904
70RING1B_27294783_Chip-Seq_ESCs_Mouse1.25583915
71ERG_21242973_ChIP-ChIP_JURKAT_Human1.24846197
72OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24049658
73STAT3_23295773_ChIP-Seq_U87_Human1.22742283
74RBPJ_22232070_ChIP-Seq_NCS_Mouse1.21697384
75TCF4_22108803_ChIP-Seq_LS180_Human1.18406232
76POU5F1_16153702_ChIP-ChIP_HESCs_Human1.16994886
77KLF5_20875108_ChIP-Seq_MESCs_Mouse1.16844505
78IRF1_19129219_ChIP-ChIP_H3396_Human1.15687696
79* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15473254
80RING1B_27294783_Chip-Seq_NPCs_Mouse1.13222878
81AR_19668381_ChIP-Seq_PC3_Human1.12932763
82* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.12581021
83GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.11156381
84P53_22127205_ChIP-Seq_FIBROBLAST_Human1.10974773
85TAL1_26923725_Chip-Seq_HPCs_Mouse1.10537449
86WT1_25993318_ChIP-Seq_PODOCYTE_Human1.09500267
87* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.09140103
88SUZ12_27294783_Chip-Seq_NPCs_Mouse1.08691957
89TP53_22573176_ChIP-Seq_HFKS_Human1.08683024
90* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.08643896
91NANOG_19829295_ChIP-Seq_ESCs_Human1.07760069
92SOX2_19829295_ChIP-Seq_ESCs_Human1.07760069
93TCF4_23295773_ChIP-Seq_U87_Human1.07635467
94TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07556581
95SMAD_19615063_ChIP-ChIP_OVARY_Human1.07013952
96KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.06742312
97TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.06539379
98EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.06178798
99PIAS1_25552417_ChIP-Seq_VCAP_Human1.06132986
100SMAD3_21741376_ChIP-Seq_ESCs_Human1.05200010
101FLI1_21867929_ChIP-Seq_TH2_Mouse1.04506882
102EZH2_27294783_Chip-Seq_NPCs_Mouse1.03728012
103RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.01983567
104YAP1_20516196_ChIP-Seq_MESCs_Mouse1.01966690
105TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.01512189
106DNAJC2_21179169_ChIP-ChIP_NT2_Human1.01321632
107AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.01037888
108ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.00913989
109PCGF2_27294783_Chip-Seq_NPCs_Mouse1.00553892
110CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00440429
111RUNX2_22187159_ChIP-Seq_PCA_Human0.99122806
112ZFP281_18757296_ChIP-ChIP_E14_Mouse0.99045147
113POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.98687239
114TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98687239
115P53_22387025_ChIP-Seq_ESCs_Mouse0.98389334
116EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.97994038
117ARNT_22903824_ChIP-Seq_MCF-7_Human0.96961734
118UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.96915303
119PRDM14_20953172_ChIP-Seq_ESCs_Human0.95882483
120CDX2_19796622_ChIP-Seq_MESCs_Mouse0.94774205
121AHR_22903824_ChIP-Seq_MCF-7_Human0.94505471
122TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.93797337
123KDM2B_26808549_Chip-Seq_K562_Human0.90735193
124TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.90610273
125NANOG_18555785_Chip-Seq_ESCs_Mouse0.89463786
126BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.89369862
127OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.87162719
128EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.86727919
129NR3C1_21868756_ChIP-Seq_MCF10A_Human0.86709794
130JUN_21703547_ChIP-Seq_K562_Human0.86513205
131WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.86230410
132ER_23166858_ChIP-Seq_MCF-7_Human0.86011851
133LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85308050
134ZNF217_24962896_ChIP-Seq_MCF-7_Human0.84907473
135SMAD4_21741376_ChIP-Seq_EPCs_Human0.84846605

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.23920925
2MP0003880_abnormal_central_pattern4.65104739
3MP0004270_analgesia3.88491765
4MP0003635_abnormal_synaptic_transmissio3.64215719
5MP0001968_abnormal_touch/_nociception3.59283486
6MP0002735_abnormal_chemical_nociception3.30107847
7MP0002736_abnormal_nociception_after3.10168102
8MP0009046_muscle_twitch3.08590723
9MP0002734_abnormal_mechanical_nocicepti2.95603908
10MP0009745_abnormal_behavioral_response2.94361910
11MP0002063_abnormal_learning/memory/cond2.93219651
12MP0002064_seizures2.76654018
13MP0005423_abnormal_somatic_nervous2.75695607
14MP0002272_abnormal_nervous_system2.58532961
15MP0006276_abnormal_autonomic_nervous2.55360403
16MP0002572_abnormal_emotion/affect_behav2.48579015
17MP0002733_abnormal_thermal_nociception2.43740597
18MP0001486_abnormal_startle_reflex2.31529991
19MP0004858_abnormal_nervous_system2.29773492
20MP0002102_abnormal_ear_morphology2.25516875
21MP0001970_abnormal_pain_threshold2.24686081
22MP0002067_abnormal_sensory_capabilities2.19713182
23MP0002184_abnormal_innervation2.10503324
24MP0000778_abnormal_nervous_system2.00680484
25MP0004811_abnormal_neuron_physiology1.96267504
26MP0001501_abnormal_sleep_pattern1.84452092
27MP0006292_abnormal_olfactory_placode1.83712930
28MP0001440_abnormal_grooming_behavior1.82763113
29MP0003122_maternal_imprinting1.82041411
30MP0001984_abnormal_olfaction1.80429612
31MP0002822_catalepsy1.80368126
32MP0008569_lethality_at_weaning1.78502537
33MP0000955_abnormal_spinal_cord1.74705030
34MP0002557_abnormal_social/conspecific_i1.74501546
35MP0009780_abnormal_chondrocyte_physiolo1.65312646
36MP0005386_behavior/neurological_phenoty1.64618208
37MP0004924_abnormal_behavior1.64618208
38MP0002837_dystrophic_cardiac_calcinosis1.63039786
39MP0008789_abnormal_olfactory_epithelium1.62805279
40MP0003787_abnormal_imprinting1.61301370
41MP0003011_delayed_dark_adaptation1.61193874
42MP0002882_abnormal_neuron_morphology1.53587123
43MP0002234_abnormal_pharynx_morphology1.53486840
44MP0002909_abnormal_adrenal_gland1.52396625
45MP0004133_heterotaxia1.51307350
46MP0001986_abnormal_taste_sensitivity1.46982786
47MP0005646_abnormal_pituitary_gland1.46855417
48MP0005645_abnormal_hypothalamus_physiol1.45918181
49MP0003890_abnormal_embryonic-extraembry1.44391364
50MP0001188_hyperpigmentation1.43348063
51MP0003136_yellow_coat_color1.40253966
52MP0002066_abnormal_motor_capabilities/c1.36061421
53MP0001529_abnormal_vocalization1.34669500
54MP0003329_amyloid_beta_deposits1.33931678
55MP0003879_abnormal_hair_cell1.32631610
56MP0004142_abnormal_muscle_tone1.32195612
57MP0000566_synostosis1.30946595
58MP0004885_abnormal_endolymph1.30502224
59MP0000569_abnormal_digit_pigmentation1.28534257
60MP0001502_abnormal_circadian_rhythm1.28177607
61MP0002938_white_spotting1.21953257
62MP0005187_abnormal_penis_morphology1.19511219
63MP0003183_abnormal_peptide_metabolism1.17654485
64MP0004215_abnormal_myocardial_fiber1.16530709
65MP0003633_abnormal_nervous_system1.16415093
66MP0001905_abnormal_dopamine_level1.14400989
67MP0000049_abnormal_middle_ear1.12569555
68MP0003119_abnormal_digestive_system1.11713508
69MP0004043_abnormal_pH_regulation1.10679420
70MP0002229_neurodegeneration1.10044640
71MP0000751_myopathy1.08584259
72MP0002152_abnormal_brain_morphology1.07916751
73MP0005410_abnormal_fertilization1.07269061
74MP0005551_abnormal_eye_electrophysiolog1.06860613
75MP0003631_nervous_system_phenotype1.06496509
76MP0000026_abnormal_inner_ear1.06418804
77MP0010386_abnormal_urinary_bladder1.06314784
78MP0002751_abnormal_autonomic_nervous1.05458654
79MP0003718_maternal_effect1.03574798
80MP0000427_abnormal_hair_cycle1.02867220
81MP0008995_early_reproductive_senescence1.01815558
82MP0004145_abnormal_muscle_electrophysio1.01249850
83MP0001293_anophthalmia1.00615260
84MP0004742_abnormal_vestibular_system1.00312663
85MP0002752_abnormal_somatic_nervous0.99246197
86MP0008877_abnormal_DNA_methylation0.98760965
87MP0002638_abnormal_pupillary_reflex0.97936587
88MP0003937_abnormal_limbs/digits/tail_de0.97739368
89MP0005195_abnormal_posterior_eye0.97545926
90MP0003938_abnormal_ear_development0.96377928
91MP0003634_abnormal_glial_cell0.92873265
92MP0005499_abnormal_olfactory_system0.92071255
93MP0005394_taste/olfaction_phenotype0.92071255
94MP0002282_abnormal_trachea_morphology0.91250596
95MP0002928_abnormal_bile_duct0.90802495
96MP0001963_abnormal_hearing_physiology0.90667919
97MP0002160_abnormal_reproductive_system0.90500595
98MP0002233_abnormal_nose_morphology0.89848789
99MP0003195_calcinosis0.89083827
100MP0008875_abnormal_xenobiotic_pharmacok0.87719575
101MP0005391_vision/eye_phenotype0.86768894
102MP0005623_abnormal_meninges_morphology0.86124999
103MP0000647_abnormal_sebaceous_gland0.85712281
104MP0003252_abnormal_bile_duct0.85464094
105MP0005084_abnormal_gallbladder_morpholo0.84382341
106MP0000631_abnormal_neuroendocrine_gland0.84069510
107MP0004147_increased_porphyrin_level0.82564449
108MP0001299_abnormal_eye_distance/0.80548540
109MP0003632_abnormal_nervous_system0.80071277
110MP0004085_abnormal_heartbeat0.75661664
111MP0002069_abnormal_eating/drinking_beha0.75428481
112MP0002653_abnormal_ependyma_morphology0.75090046
113MP0001485_abnormal_pinna_reflex0.70351025
114MP0003121_genomic_imprinting0.69101851
115MP0005171_absent_coat_pigmentation0.68036552
116MP0008872_abnormal_physiological_respon0.67441082
117MP0001348_abnormal_lacrimal_gland0.66788370
118MP0001664_abnormal_digestion0.66721261
119MP0002876_abnormal_thyroid_physiology0.65211478
120MP0005253_abnormal_eye_physiology0.65210446
121MP0000534_abnormal_ureter_morphology0.65048912
122MP0003861_abnormal_nervous_system0.64718914
123MP0004233_abnormal_muscle_weight0.64431948
124MP0002090_abnormal_vision0.64243764
125MP0006072_abnormal_retinal_apoptosis0.63950569
126MP0004036_abnormal_muscle_relaxation0.63783803
127MP0001943_abnormal_respiration0.62508379
128MP0003698_abnormal_male_reproductive0.61120858
129MP0000013_abnormal_adipose_tissue0.61071331
130MP0008874_decreased_physiological_sensi0.59974400
131MP0003137_abnormal_impulse_conducting0.57881345
132MP0004084_abnormal_cardiac_muscle0.57540239
133MP0003283_abnormal_digestive_organ0.57441466
134MP0001177_atelectasis0.55467854

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)6.62171349
2Focal motor seizures (HP:0011153)6.16271477
3Progressive cerebellar ataxia (HP:0002073)4.90138909
4Focal seizures (HP:0007359)4.77247621
5Atonic seizures (HP:0010819)4.41526227
6Febrile seizures (HP:0002373)4.35244045
7Action tremor (HP:0002345)4.33253563
8Epileptic encephalopathy (HP:0200134)4.19543868
9Visual hallucinations (HP:0002367)4.17304356
10Pancreatic fibrosis (HP:0100732)3.95810435
11True hermaphroditism (HP:0010459)3.87108859
12Pancreatic cysts (HP:0001737)3.84419985
13Abnormality of midbrain morphology (HP:0002418)3.78936838
14Molar tooth sign on MRI (HP:0002419)3.78936838
15Neuroendocrine neoplasm (HP:0100634)3.57145111
16Nephronophthisis (HP:0000090)3.57102675
17Pheochromocytoma (HP:0002666)3.53509791
18Supranuclear gaze palsy (HP:0000605)3.42648823
19Ulnar claw (HP:0001178)3.41098502
20Absence seizures (HP:0002121)3.38850756
21Insidious onset (HP:0003587)3.37012976
22Termporal pattern (HP:0011008)3.37012976
23Ankle clonus (HP:0011448)3.27457279
24Generalized tonic-clonic seizures (HP:0002069)3.21988020
25Abnormal respiratory motile cilium morphology (HP:0005938)3.09881146
26Abnormal respiratory epithelium morphology (HP:0012253)3.09881146
27Abnormal ciliary motility (HP:0012262)3.05342951
28Dialeptic seizures (HP:0011146)3.02708957
29Abnormal respiratory motile cilium physiology (HP:0012261)3.02136983
30Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.01494430
31Bundle branch block (HP:0011710)3.01437318
32Chronic hepatic failure (HP:0100626)2.94871293
33Abnormality of the renal medulla (HP:0100957)2.90008930
34Abnormal eating behavior (HP:0100738)2.86333410
35Amblyopia (HP:0000646)2.85811139
36Truncal ataxia (HP:0002078)2.84519000
37Abnormality of the labia minora (HP:0012880)2.82598354
38Gaze-evoked nystagmus (HP:0000640)2.82405553
39Neoplasm of the peripheral nervous system (HP:0100007)2.80496948
40Hypoplasia of the brainstem (HP:0002365)2.79216582
41Aplasia/Hypoplasia of the brainstem (HP:0007362)2.79216582
42Progressive inability to walk (HP:0002505)2.76914188
43Limb dystonia (HP:0002451)2.72419144
44Pendular nystagmus (HP:0012043)2.69151500
45Depression (HP:0000716)2.66524999
46Cystic liver disease (HP:0006706)2.66247908
47Impaired vibration sensation in the lower limbs (HP:0002166)2.64913384
48Poor eye contact (HP:0000817)2.60899386
49Urinary bladder sphincter dysfunction (HP:0002839)2.58919851
50Failure to thrive in infancy (HP:0001531)2.56786272
51Gait imbalance (HP:0002141)2.56343448
52Broad-based gait (HP:0002136)2.54503567
53Lissencephaly (HP:0001339)2.51778586
54Aplasia/Hypoplasia of the tongue (HP:0010295)2.50165364
55Rhinitis (HP:0012384)2.49411679
56Anxiety (HP:0000739)2.46648265
57Sclerocornea (HP:0000647)2.46009325
58Urinary urgency (HP:0000012)2.45388005
59Anterior segment dysgenesis (HP:0007700)2.44606549
60Type II lissencephaly (HP:0007260)2.42262210
61Abnormality of the lower motor neuron (HP:0002366)2.41576401
62Mutism (HP:0002300)2.39549084
63Nephrogenic diabetes insipidus (HP:0009806)2.39076168
64Impaired smooth pursuit (HP:0007772)2.36718885
65Scanning speech (HP:0002168)2.35709812
66Specific learning disability (HP:0001328)2.35452946
67Polyphagia (HP:0002591)2.34080473
68Abnormality of the renal cortex (HP:0011035)2.33406775
69Dysdiadochokinesis (HP:0002075)2.32032946
70Occipital encephalocele (HP:0002085)2.31800003
71Hemiparesis (HP:0001269)2.31339859
72Absent speech (HP:0001344)2.29145016
73Hyperventilation (HP:0002883)2.28032040
74Retinal dysplasia (HP:0007973)2.27525378
75Impaired social interactions (HP:0000735)2.26077896
76Abnormal social behavior (HP:0012433)2.26077896
77Anencephaly (HP:0002323)2.25022328
78Spastic gait (HP:0002064)2.23945076
79Postaxial hand polydactyly (HP:0001162)2.22325422
80Central scotoma (HP:0000603)2.20017218
81Congenital stationary night blindness (HP:0007642)2.18916995
82Congenital primary aphakia (HP:0007707)2.18751476
83Inability to walk (HP:0002540)2.18272057
84Narrow forehead (HP:0000341)2.16375431
85Annular pancreas (HP:0001734)2.14155444
86Postaxial foot polydactyly (HP:0001830)2.13923256
87Impaired pain sensation (HP:0007328)2.13650184
88Abnormality of pain sensation (HP:0010832)2.13650184
89Genetic anticipation (HP:0003743)2.12652101
90Optic nerve hypoplasia (HP:0000609)2.12410385
91Lower limb muscle weakness (HP:0007340)2.12109978
92Buphthalmos (HP:0000557)2.11899970
93Torticollis (HP:0000473)2.11898046
94Abnormality of ocular smooth pursuit (HP:0000617)2.11099309
95Fetal akinesia sequence (HP:0001989)2.10475950
96Medial flaring of the eyebrow (HP:0010747)2.10396281
97Dysmetria (HP:0001310)2.07115313
98Agitation (HP:0000713)2.06377260
99Intestinal atresia (HP:0011100)2.06223194
100Postural instability (HP:0002172)2.05849633
101Steppage gait (HP:0003376)2.05142932
102Hypoventilation (HP:0002791)2.02566682
103Pachygyria (HP:0001302)2.01651647
104Abnormal hair whorl (HP:0010721)2.01044569
105Megalencephaly (HP:0001355)1.99786911
106Congenital hepatic fibrosis (HP:0002612)1.99097063
107Focal dystonia (HP:0004373)1.98477013
108Epileptiform EEG discharges (HP:0011182)1.97602560
109Methylmalonic acidemia (HP:0002912)1.97412182
110Hyperglycinemia (HP:0002154)1.97028328
111Ventricular fibrillation (HP:0001663)1.94738355
112Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.94362789
113Tubular atrophy (HP:0000092)1.94008539
114Abnormality of macular pigmentation (HP:0008002)1.93634690
115Thyroid-stimulating hormone excess (HP:0002925)1.93372649
116Hypercortisolism (HP:0001578)1.93056134
117Protruding tongue (HP:0010808)1.92236854
118Abnormality of the corticospinal tract (HP:0002492)1.92197904
119Oligodactyly (hands) (HP:0001180)1.91814424
120EEG with generalized epileptiform discharges (HP:0011198)1.90951644
121Abnormality of the vocal cords (HP:0008777)1.90652470
122Bradykinesia (HP:0002067)1.89921464
123Genital tract atresia (HP:0001827)1.89638511
124Poor coordination (HP:0002370)1.89089146
125Aplasia/Hypoplasia of the tibia (HP:0005772)1.88716765
126Pointed chin (HP:0000307)1.88655367
127Dynein arm defect of respiratory motile cilia (HP:0012255)1.88323312
128Absent/shortened dynein arms (HP:0200106)1.88323312
129Preaxial hand polydactyly (HP:0001177)1.87504319
130Intention tremor (HP:0002080)1.87352581
131Oculomotor apraxia (HP:0000657)1.86635240
132Hammertoe (HP:0001765)1.86483743
133Impaired vibratory sensation (HP:0002495)1.86161601
134Abolished electroretinogram (ERG) (HP:0000550)1.85989693
135Myotonia (HP:0002486)1.85530718
136Vaginal atresia (HP:0000148)1.85466853
137Excessive salivation (HP:0003781)1.85339283
138Drooling (HP:0002307)1.85339283
139Male pseudohermaphroditism (HP:0000037)1.84059764
140Rib fusion (HP:0000902)1.83748088
141Renal cortical cysts (HP:0000803)1.83077619
142Hypsarrhythmia (HP:0002521)1.82106976
143Abnormal drinking behavior (HP:0030082)1.81814416
144Polydipsia (HP:0001959)1.81814416
145Chorioretinal atrophy (HP:0000533)1.80307112
146Keratoconus (HP:0000563)1.79336873
147Increased corneal curvature (HP:0100692)1.79336873
148Stereotypic behavior (HP:0000733)1.78820781
149Spinal canal stenosis (HP:0003416)1.78666256
150Supernumerary spleens (HP:0009799)1.78284450
151Poor suck (HP:0002033)1.78017825
152Incomplete penetrance (HP:0003829)1.76920201
153Narrow nasal bridge (HP:0000446)1.76845407
154Hemiplegia (HP:0002301)1.75463145
155Attenuation of retinal blood vessels (HP:0007843)1.75428819
156Cerebellar dysplasia (HP:0007033)1.74602245
157Tubulointerstitial nephritis (HP:0001970)1.74197834
158Retinitis pigmentosa (HP:0000510)1.73382954
159Furrowed tongue (HP:0000221)1.70610407
160Aganglionic megacolon (HP:0002251)1.70127603
161Dandy-Walker malformation (HP:0001305)1.69550085
162Bile duct proliferation (HP:0001408)1.68685293
163Abnormal biliary tract physiology (HP:0012439)1.68685293
164Patellar aplasia (HP:0006443)1.68100309
165Acute necrotizing encephalopathy (HP:0006965)1.64220533
166Chronic bronchitis (HP:0004469)1.63357734

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.27580748
2FRK3.67177034
3MINK13.33302872
4MARK13.30656422
5MAP3K93.28926453
6MAP3K43.19561892
7CASK2.93730413
8MAP2K72.93694256
9MAP3K122.90189045
10MAP4K22.83642340
11EPHA42.72502904
12BMPR1B2.10174428
13MAP2K42.09275286
14PAK62.09245389
15ADRBK21.96901315
16TRIM281.89232172
17DAPK21.88904761
18PIK3CG1.88131063
19KSR21.84841614
20LMTK21.83210776
21MAPK131.80899321
22PRKD31.80171221
23INSRR1.71845465
24NTRK21.70575189
25CAMKK11.66405243
26GRK11.59865309
27NTRK11.56041057
28KSR11.55881763
29SIK31.52110084
30ZAK1.48175871
31CDK191.45158931
32ACVR1B1.44360924
33PLK21.44208095
34CAMKK21.40604861
35PHKG21.40320190
36PHKG11.40320190
37RIPK41.38556337
38SGK2231.35706622
39SGK4941.35706622
40MKNK21.35337870
41CDK51.32609412
42PRPF4B1.32068878
43GRK51.31582758
44ARAF1.25137031
45LIMK11.24664740
46LATS21.23536865
47DAPK11.22316251
48SGK21.18031102
49NUAK11.17082288
50STK381.15966796
51EPHA31.14390210
52CSNK1G31.14357751
53TNIK1.14143523
54CSNK1G11.13445576
55RET1.11348628
56UHMK11.10020422
57CSNK1A1L1.04723419
58MAPK151.03406345
59PRKCG1.02018950
60MAP3K21.01890893
61EPHB21.00972213
62WNK10.99692211
63CCNB10.97143411
64PKN10.94976342
65CDK180.91986949
66DYRK30.90746657
67MKNK10.89570393
68SIK20.88655427
69CDK140.88439921
70STK38L0.88078149
71STK390.85820661
72TLK10.84241353
73CDK150.83286825
74TYRO30.82256322
75CAMK2A0.79651122
76SGK30.79258709
77TAOK30.75897130
78CDK11A0.72976194
79TGFBR10.72732879
80PDK40.72025086
81PDK30.72025086
82BCR0.71768685
83FES0.70766992
84NEK10.69759699
85VRK10.69554490
86PRKCH0.66689178
87STK110.66249662
88PLK30.64482374
89PLK40.64215930
90PTK2B0.63990703
91AKT30.63072665
92RPS6KA20.62518725
93MAP2K10.62425735
94CAMK2B0.61289261
95FGFR20.61005912
96WEE10.60185402
97PAK30.59372116
98PINK10.58245076
99PNCK0.58060587
100FER0.56738369
101WNK30.56268350
102ERBB30.56154021
103OXSR10.55537954
104ADRBK10.54815068
105PRKCE0.52725672
106DYRK20.52517057
107DYRK1A0.51888326
108CSNK1G20.51470456
109SGK10.50235900
110BCKDK0.49870865
111ERBB20.49752026
112MAP3K10.48955116
113PRKACA0.48659674
114SRPK10.48232839
115TNK20.47590217
116MUSK0.46394645
117BRSK10.46239662
118PRKG10.45488078
119CAMK2G0.45058623
120SCYL20.44557197
121TAOK10.44487783
122WNK40.44371290
123PIK3CA0.44081163
124BRAF0.43833785
125CSNK1A10.43823882
126TIE10.43557192
127CSNK1D0.42962358
128RAF10.42914343
129BRSK20.41996681
130CDK30.41798651
131PRKCZ0.41751858
132CAMK10.41290026
133PLK10.41229691
134MAPK100.40792168
135MAP3K110.40263034
136MARK20.39192158
137STK30.38479431
138TESK10.38445444
139MATK0.37840597
140PRKACB0.37720529
141RPS6KA30.35884824
142TSSK60.35196794
143CAMK2D0.35113653
144BMPR20.34401658
145PDK10.32644743
146PRKAA10.32172009
147OBSCN0.31687040
148CAMK40.30644356

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.58086832
2Nicotine addiction_Homo sapiens_hsa050333.33713343
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.78011314
4Olfactory transduction_Homo sapiens_hsa047402.77472033
5Circadian entrainment_Homo sapiens_hsa047132.44939975
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.39156534
7GABAergic synapse_Homo sapiens_hsa047272.36070858
8Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.27909780
9Long-term potentiation_Homo sapiens_hsa047202.25979884
10Glutamatergic synapse_Homo sapiens_hsa047242.21966271
11Butanoate metabolism_Homo sapiens_hsa006502.17184854
12Morphine addiction_Homo sapiens_hsa050322.15101242
13Amphetamine addiction_Homo sapiens_hsa050312.13704798
14Dopaminergic synapse_Homo sapiens_hsa047282.12014722
15Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.05085973
16Cholinergic synapse_Homo sapiens_hsa047251.93334649
17Protein export_Homo sapiens_hsa030601.90020473
18Insulin secretion_Homo sapiens_hsa049111.89424183
19Taste transduction_Homo sapiens_hsa047421.86410274
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.80672052
21Salivary secretion_Homo sapiens_hsa049701.76838709
22Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.67556315
23Aldosterone synthesis and secretion_Homo sapiens_hsa049251.65389208
24Primary bile acid biosynthesis_Homo sapiens_hsa001201.58342354
25Gastric acid secretion_Homo sapiens_hsa049711.57603398
26Basal transcription factors_Homo sapiens_hsa030221.56904344
27Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.55880341
28Linoleic acid metabolism_Homo sapiens_hsa005911.54862961
29Serotonergic synapse_Homo sapiens_hsa047261.54829267
30Collecting duct acid secretion_Homo sapiens_hsa049661.53318614
31Nitrogen metabolism_Homo sapiens_hsa009101.52731237
32Oxytocin signaling pathway_Homo sapiens_hsa049211.50362985
33Fanconi anemia pathway_Homo sapiens_hsa034601.49476551
34Propanoate metabolism_Homo sapiens_hsa006401.48281610
35Cocaine addiction_Homo sapiens_hsa050301.47809157
36Long-term depression_Homo sapiens_hsa047301.47005499
37Renin secretion_Homo sapiens_hsa049241.46565269
38Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.45831986
39Huntingtons disease_Homo sapiens_hsa050161.41520687
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.39046177
41Phototransduction_Homo sapiens_hsa047441.36485014
42Gap junction_Homo sapiens_hsa045401.36396034
43GnRH signaling pathway_Homo sapiens_hsa049121.35710926
44Selenocompound metabolism_Homo sapiens_hsa004501.34495051
45RNA polymerase_Homo sapiens_hsa030201.34249811
46Ether lipid metabolism_Homo sapiens_hsa005651.33814869
47Calcium signaling pathway_Homo sapiens_hsa040201.32748663
48Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.31276986
49alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.30255693
50Type II diabetes mellitus_Homo sapiens_hsa049301.29091528
51Maturity onset diabetes of the young_Homo sapiens_hsa049501.26716848
52Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.25093492
53Phosphatidylinositol signaling system_Homo sapiens_hsa040701.25055645
54Tryptophan metabolism_Homo sapiens_hsa003801.24526844
55Glioma_Homo sapiens_hsa052141.24054134
56Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.19194642
57Estrogen signaling pathway_Homo sapiens_hsa049151.18720320
58Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.16366903
59ErbB signaling pathway_Homo sapiens_hsa040121.15959739
60Axon guidance_Homo sapiens_hsa043601.13841295
61cAMP signaling pathway_Homo sapiens_hsa040241.13355925
62Steroid biosynthesis_Homo sapiens_hsa001001.13060647
63Caffeine metabolism_Homo sapiens_hsa002321.11001434
64Vibrio cholerae infection_Homo sapiens_hsa051101.08487310
65Oocyte meiosis_Homo sapiens_hsa041141.07614760
66Dorso-ventral axis formation_Homo sapiens_hsa043201.05397644
67Cardiac muscle contraction_Homo sapiens_hsa042601.04801918
68Hedgehog signaling pathway_Homo sapiens_hsa043401.03812087
69Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.03078534
70Homologous recombination_Homo sapiens_hsa034401.02715189
71Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.98064668
72Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.96802327
73Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.95968525
74Melanogenesis_Homo sapiens_hsa049160.93990333
75Endometrial cancer_Homo sapiens_hsa052130.93674747
76Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.92815606
77cGMP-PKG signaling pathway_Homo sapiens_hsa040220.91105080
78RNA degradation_Homo sapiens_hsa030180.90519163
79Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.89922983
80Neurotrophin signaling pathway_Homo sapiens_hsa047220.89715349
81Steroid hormone biosynthesis_Homo sapiens_hsa001400.88874438
82Regulation of autophagy_Homo sapiens_hsa041400.88042481
83Carbohydrate digestion and absorption_Homo sapiens_hsa049730.87021449
84ABC transporters_Homo sapiens_hsa020100.85136891
85Phospholipase D signaling pathway_Homo sapiens_hsa040720.84230415
86VEGF signaling pathway_Homo sapiens_hsa043700.82533037
87Peroxisome_Homo sapiens_hsa041460.82341396
88Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.82174832
89Retinol metabolism_Homo sapiens_hsa008300.78937149
90beta-Alanine metabolism_Homo sapiens_hsa004100.78610934
91Chemical carcinogenesis_Homo sapiens_hsa052040.76539290
92Basal cell carcinoma_Homo sapiens_hsa052170.75356020
93Non-homologous end-joining_Homo sapiens_hsa034500.74987037
94Vascular smooth muscle contraction_Homo sapiens_hsa042700.74516234
95MAPK signaling pathway_Homo sapiens_hsa040100.73956179
96Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.72227868
97Choline metabolism in cancer_Homo sapiens_hsa052310.72011026
98Colorectal cancer_Homo sapiens_hsa052100.70802475
99Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.70210144
100Thyroid hormone signaling pathway_Homo sapiens_hsa049190.68566167
101Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.68166413
102Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.67194460
103Ras signaling pathway_Homo sapiens_hsa040140.67125424
104Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.66262818
105Inositol phosphate metabolism_Homo sapiens_hsa005620.65499056
106Glucagon signaling pathway_Homo sapiens_hsa049220.64800744
107Hippo signaling pathway_Homo sapiens_hsa043900.64415310
108Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.64330229
109Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.63247913
110Central carbon metabolism in cancer_Homo sapiens_hsa052300.62381263
111SNARE interactions in vesicular transport_Homo sapiens_hsa041300.62320970
112Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.61334254
113Alcoholism_Homo sapiens_hsa050340.60822003
114Thyroid hormone synthesis_Homo sapiens_hsa049180.60072213
115Purine metabolism_Homo sapiens_hsa002300.59624358
116Non-small cell lung cancer_Homo sapiens_hsa052230.59143523
117Dilated cardiomyopathy_Homo sapiens_hsa054140.59080955
118Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.58925229
119Endocytosis_Homo sapiens_hsa041440.58455089
120Circadian rhythm_Homo sapiens_hsa047100.58151696
121Melanoma_Homo sapiens_hsa052180.57806164
122Prolactin signaling pathway_Homo sapiens_hsa049170.57367519
123Insulin signaling pathway_Homo sapiens_hsa049100.57169397
124Renal cell carcinoma_Homo sapiens_hsa052110.57023034
125Rap1 signaling pathway_Homo sapiens_hsa040150.56896959
126Pancreatic secretion_Homo sapiens_hsa049720.56734006
127mTOR signaling pathway_Homo sapiens_hsa041500.56606089
128Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.56002207
129Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.55027526
130Sphingolipid signaling pathway_Homo sapiens_hsa040710.54141517
131Alzheimers disease_Homo sapiens_hsa050100.50722473
132Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.48277975
133Metabolic pathways_Homo sapiens_hsa011000.47991457
134Cysteine and methionine metabolism_Homo sapiens_hsa002700.47893710
135Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.43245429
136Type I diabetes mellitus_Homo sapiens_hsa049400.43107150
137Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.43102450
138Wnt signaling pathway_Homo sapiens_hsa043100.42099317
139Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.42060210
140Longevity regulating pathway - mammal_Homo sapiens_hsa042110.41408365
141Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.41273824
142Oxidative phosphorylation_Homo sapiens_hsa001900.40419958
143Parkinsons disease_Homo sapiens_hsa050120.40091922
144Fatty acid metabolism_Homo sapiens_hsa012120.40060155
145Histidine metabolism_Homo sapiens_hsa003400.39701460
146Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.39506801
147Salmonella infection_Homo sapiens_hsa051320.39238255
148Phagosome_Homo sapiens_hsa041450.38766302
149Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.36792526
150Fatty acid elongation_Homo sapiens_hsa000620.36385220
151Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.36363142
152Chemokine signaling pathway_Homo sapiens_hsa040620.34651532
153Fatty acid biosynthesis_Homo sapiens_hsa000610.34366719
154Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.33799277
155Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.32993577
156Ovarian steroidogenesis_Homo sapiens_hsa049130.31095817
157Arachidonic acid metabolism_Homo sapiens_hsa005900.30834853
158Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.30576589

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