LRRC52

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1plasma membrane fusion (GO:0045026)9.74570924
2motile cilium assembly (GO:0044458)9.06960791
3cell-cell recognition (GO:0009988)9.01860794
4epithelial cilium movement (GO:0003351)8.95569158
5cilium or flagellum-dependent cell motility (GO:0001539)8.87776213
6binding of sperm to zona pellucida (GO:0007339)8.86073190
7reproduction (GO:0000003)8.79229764
8axonemal dynein complex assembly (GO:0070286)8.45654054
9spermatid development (GO:0007286)8.44808143
10response to pheromone (GO:0019236)8.35292260
11regulation of cilium movement (GO:0003352)7.63420685
12cilium movement (GO:0003341)7.25333654
13epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.09893348
14sperm capacitation (GO:0048240)6.89684338
15organic cation transport (GO:0015695)6.81300971
16single fertilization (GO:0007338)6.68979540
17negative regulation of inclusion body assembly (GO:0090084)6.44707350
18piRNA metabolic process (GO:0034587)6.40641436
19rRNA methylation (GO:0031167)6.34639687
20protein targeting to Golgi (GO:0000042)6.19532516
21synaptonemal complex organization (GO:0070193)6.08383331
22establishment of protein localization to Golgi (GO:0072600)5.93989524
23microtubule depolymerization (GO:0007019)5.86300991
24retrograde transport, vesicle recycling within Golgi (GO:0000301)5.81720797
25spermatogenesis (GO:0007283)5.77576490
26male gamete generation (GO:0048232)5.74928095
27male meiosis (GO:0007140)5.72297454
28synaptonemal complex assembly (GO:0007130)5.71560150
29fertilization (GO:0009566)5.63820776
30cellular ketone body metabolic process (GO:0046950)5.63744803
31phosphatidylethanolamine biosynthetic process (GO:0006646)5.61459642
32centriole replication (GO:0007099)5.49182631
33regulation of inclusion body assembly (GO:0090083)5.35973795
34rRNA modification (GO:0000154)5.32778788
35gamete generation (GO:0007276)5.27330561
36phosphatidylethanolamine metabolic process (GO:0046337)5.27222805
37coenzyme catabolic process (GO:0009109)5.08110496
38ketone body metabolic process (GO:1902224)4.97036674
39regulation of transcription involved in cell fate commitment (GO:0060850)4.93773240
40antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.93356731
41centriole assembly (GO:0098534)4.85249328
42amino-acid betaine transport (GO:0015838)4.81540564
43carnitine transport (GO:0015879)4.81540564
44calcium ion-dependent exocytosis (GO:0017156)4.78666610
45cellular process involved in reproduction in multicellular organism (GO:0022412)4.68782963
46regulation of Rab GTPase activity (GO:0032313)4.68603026
47positive regulation of Rab GTPase activity (GO:0032851)4.68603026
48carnitine transmembrane transport (GO:1902603)4.65498392
49glycerol ether metabolic process (GO:0006662)4.65397894
50ventricular system development (GO:0021591)4.61350439
51germ cell development (GO:0007281)4.59115448
52protein localization to Golgi apparatus (GO:0034067)4.51879174
53glomerular visceral epithelial cell development (GO:0072015)4.43263510
54RNA destabilization (GO:0050779)4.42585152
55regulation of microtubule-based movement (GO:0060632)4.40808164
56cell recognition (GO:0008037)4.39515451
57glomerular epithelial cell development (GO:0072310)4.28429426
58ether metabolic process (GO:0018904)4.27235453
59multicellular organismal reproductive process (GO:0048609)4.18917480
60gonadal mesoderm development (GO:0007506)4.10858347
61spermatid nucleus differentiation (GO:0007289)4.10597414
62male meiosis I (GO:0007141)4.06622492
63microtubule severing (GO:0051013)4.06398892
64left/right pattern formation (GO:0060972)4.01790295
65chromosome condensation (GO:0030261)4.01243268
66DNA methylation involved in gamete generation (GO:0043046)3.99369692
67chromosome organization involved in meiosis (GO:0070192)3.81985356
68single strand break repair (GO:0000012)3.80501229
69quaternary ammonium group transport (GO:0015697)3.79781721
70DNA packaging (GO:0006323)3.78211910
71negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.77694671
72multicellular organismal movement (GO:0050879)3.77402336
73musculoskeletal movement (GO:0050881)3.77402336
74negative regulation of Rho protein signal transduction (GO:0035024)3.74622996
75regulation of somitogenesis (GO:0014807)3.71704161
76regulation of centriole replication (GO:0046599)3.65113822
77urinary tract smooth muscle contraction (GO:0014848)3.62465955
78outflow tract septum morphogenesis (GO:0003148)3.62378669
79nucleus organization (GO:0006997)3.61698815
80chromatin silencing (GO:0006342)3.55276406
81seminiferous tubule development (GO:0072520)3.54611991
82multicellular organismal development (GO:0007275)3.50693036
83meiotic nuclear division (GO:0007126)3.43222163
84glycolytic process (GO:0006096)3.41170756
85negative regulation of potassium ion transmembrane transport (GO:1901380)3.32005897
86chaperone-mediated protein complex assembly (GO:0051131)3.26520013
87growth hormone secretion (GO:0030252)3.22054252
88microtubule polymerization or depolymerization (GO:0031109)3.20920974
89carnitine shuttle (GO:0006853)3.16858625
90sexual reproduction (GO:0019953)3.16803599
91cofactor catabolic process (GO:0051187)3.12163485
92metanephric mesenchyme development (GO:0072075)3.11739703
93genitalia morphogenesis (GO:0035112)3.10197532
94otic vesicle formation (GO:0030916)3.07240974
95protein polyglutamylation (GO:0018095)3.05814339
96meiosis I (GO:0007127)3.04247166
97protein depolymerization (GO:0051261)3.03299887
98alditol metabolic process (GO:0019400)2.97801042
99peptidyl-threonine dephosphorylation (GO:0035970)2.94262843
100cellular response to pH (GO:0071467)2.94062884
101NAD biosynthetic process (GO:0009435)2.94007702
102male sex determination (GO:0030238)2.93085437
103cerebral cortex neuron differentiation (GO:0021895)2.92459807
104membrane protein intracellular domain proteolysis (GO:0031293)2.87756223
105nephron tubule morphogenesis (GO:0072078)2.83508989
106nephron epithelium morphogenesis (GO:0072088)2.83508989
107polyol catabolic process (GO:0046174)2.83429400
108cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.82917328
109histone H3-K9 demethylation (GO:0033169)2.81469302
110cranial nerve morphogenesis (GO:0021602)2.76852879
111negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.76079711
112cellular carbohydrate catabolic process (GO:0044275)2.76051262
113muscle filament sliding (GO:0030049)2.75474561
114actin-myosin filament sliding (GO:0033275)2.75474561
115positive regulation of growth hormone secretion (GO:0060124)2.73760197
116Golgi to endosome transport (GO:0006895)2.72186744
117homeostasis of number of cells within a tissue (GO:0048873)2.68603309
118negative regulation of organelle assembly (GO:1902116)2.68322146
119cellular component assembly involved in morphogenesis (GO:0010927)2.66355803
120glycerol metabolic process (GO:0006071)2.66205878
121negative regulation of skeletal muscle tissue development (GO:0048642)2.64085292
122fatty acid transmembrane transport (GO:1902001)2.63883127
123protein K11-linked deubiquitination (GO:0035871)2.62396772
124regulation of skeletal muscle contraction (GO:0014819)2.60892333
125monoubiquitinated protein deubiquitination (GO:0035520)2.60857283
126regulation of spindle checkpoint (GO:0090231)2.56684625
127left/right axis specification (GO:0070986)2.56544226
128intestinal epithelial cell development (GO:0060576)2.56293546
129tricarboxylic acid cycle (GO:0006099)2.55514492
130interferon-gamma secretion (GO:0072643)2.54313093
131protein localization to cilium (GO:0061512)2.49805243
132meiotic cell cycle (GO:0051321)2.49254863
133axoneme assembly (GO:0035082)2.48217150
134polyamine biosynthetic process (GO:0006596)2.47484937
135regulation of meiosis I (GO:0060631)2.47415014
136nucleoside diphosphate phosphorylation (GO:0006165)2.44696731
137regulation of acrosome reaction (GO:0060046)2.44353170
138sequestering of actin monomers (GO:0042989)2.42773766
139plasma membrane repair (GO:0001778)2.42244485
140sarcomere organization (GO:0045214)2.41438670
141pyruvate metabolic process (GO:0006090)2.40779586
142protein refolding (GO:0042026)2.38684278
143cell wall macromolecule catabolic process (GO:0016998)13.1437340
144cell wall macromolecule metabolic process (GO:0044036)13.1437340
145fusion of sperm to egg plasma membrane (GO:0007342)12.8120991
146sperm motility (GO:0030317)11.9421979
147acrosome assembly (GO:0001675)10.5922040
148acrosome reaction (GO:0007340)10.5853293
149multicellular organism reproduction (GO:0032504)10.3992295
150sperm-egg recognition (GO:0035036)10.1090169

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse7.32082938
2MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human4.11754343
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.96456697
4EZH2_22144423_ChIP-Seq_EOC_Human3.74432873
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.60835415
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.59416682
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.33900379
8PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse3.16930936
9BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.45709868
10VDR_22108803_ChIP-Seq_LS180_Human2.31747571
11STAT6_21828071_ChIP-Seq_BEAS2B_Human2.21965053
12CTBP1_25329375_ChIP-Seq_LNCAP_Human2.19686210
13GATA1_26923725_Chip-Seq_HPCs_Mouse2.10333300
14GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.08632923
15FLI1_27457419_Chip-Seq_LIVER_Mouse2.05670269
16DROSHA_22980978_ChIP-Seq_HELA_Human2.03561170
17CBX2_27304074_Chip-Seq_ESCs_Mouse2.03359825
18FUS_26573619_Chip-Seq_HEK293_Human2.01773383
19ZNF274_21170338_ChIP-Seq_K562_Hela1.99745077
20EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.92785993
21PCGF2_27294783_Chip-Seq_ESCs_Mouse1.86095760
22KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.84608935
23VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.81990423
24NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.77030432
25UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.74070466
26ERA_21632823_ChIP-Seq_H3396_Human1.72881529
27MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.72108967
28ER_23166858_ChIP-Seq_MCF-7_Human1.70849316
29RAC3_21632823_ChIP-Seq_H3396_Human1.69674642
30PCGF2_27294783_Chip-Seq_NPCs_Mouse1.66429799
31PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.62833962
32EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.62606443
33* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.60498412
34TDRD3_21172665_ChIP-Seq_MCF-7_Human1.58054862
35WDR5_24793694_ChIP-Seq_LNCAP_Human1.54362246
36BCL6_27268052_Chip-Seq_Bcells_Human1.53754715
37STAT1_17558387_ChIP-Seq_HELA_Human1.53740278
38ELF1_20517297_ChIP-Seq_JURKAT_Human1.53622939
39E2F1_20622854_ChIP-Seq_HELA_Human1.47087390
40ELK4_26923725_Chip-Seq_MESODERM_Mouse1.44031895
41EZH2_27294783_Chip-Seq_ESCs_Mouse1.42921286
42ARNT_22903824_ChIP-Seq_MCF-7_Human1.40953991
43P300_19829295_ChIP-Seq_ESCs_Human1.40886046
44AR_25329375_ChIP-Seq_VCAP_Human1.40525693
45TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.40412325
46OCT4_20526341_ChIP-Seq_ESCs_Human1.40244991
47TAF2_19829295_ChIP-Seq_ESCs_Human1.39905395
48TAF15_26573619_Chip-Seq_HEK293_Human1.39858922
49KDM2B_26808549_Chip-Seq_REH_Human1.39545736
50SMAD3_21741376_ChIP-Seq_EPCs_Human1.38787444
51GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.38701095
52SMAD4_21741376_ChIP-Seq_EPCs_Human1.37513071
53BCOR_27268052_Chip-Seq_Bcells_Human1.36902471
54CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.36779033
55SMC4_20622854_ChIP-Seq_HELA_Human1.36692320
56TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36423310
57PHF8_20622854_ChIP-Seq_HELA_Human1.35749805
58ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.35670903
59SOX2_22085726_ChIP-Seq_NPCs_Mouse1.34729728
60FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.34365005
61PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.34172187
62TAL1_26923725_Chip-Seq_HPCs_Mouse1.33332277
63ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.33279750
64CTCF_20526341_ChIP-Seq_ESCs_Human1.32301974
65AUTS2_25519132_ChIP-Seq_293T-REX_Human1.31476225
66TP53_18474530_ChIP-ChIP_U2OS_Human1.30760385
67ZFP57_27257070_Chip-Seq_ESCs_Mouse1.30591510
68* HNFA_21074721_ChIP-Seq_CACO-2_Human1.30411492
69IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.30216267
70CBP_20019798_ChIP-Seq_JUKART_Human1.30216267
71* CBX2_22325352_ChIP-Seq_293T-Rex_Human1.28829519
72ETV2_25802403_ChIP-Seq_MESCs_Mouse1.27995316
73RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.27972037
74GATA3_21878914_ChIP-Seq_MCF-7_Human1.27704427
75CTBP2_25329375_ChIP-Seq_LNCAP_Human1.27570711
76CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.26156776
77KAP1_22055183_ChIP-Seq_ESCs_Mouse1.25454643
78TOP2B_26459242_ChIP-Seq_MCF-7_Human1.24069691
79* TP63_22573176_ChIP-Seq_HFKS_Human1.23877500
80* ETV1_20927104_ChIP-Seq_GIST48_Human1.23676676
81GF1_26923725_Chip-Seq_HPCs_Mouse1.23540555
82REST_21632747_ChIP-Seq_MESCs_Mouse1.22744498
83* CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.22587585
84* RBPJ_21746931_ChIP-Seq_IB4_Human1.21768466
85ERG_20517297_ChIP-Seq_VCAP_Human1.20622972
86RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.19661592
87TBX20_22080862_ChIP-Seq_HEART_Mouse1.18404984
88TBX20_22328084_ChIP-Seq_HEART_Mouse1.18404984
89SMAD3_21741376_ChIP-Seq_ESCs_Human1.18374562
90* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.18016230
91* NFE2_27457419_Chip-Seq_LIVER_Mouse1.17832695
92LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.17426865
93EZH2_27304074_Chip-Seq_ESCs_Mouse1.17291997
94RAD21_21589869_ChIP-Seq_MESCs_Mouse1.17162066
95FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.17037273
96* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.15970274
97* PHF8_20622853_ChIP-Seq_HELA_Human1.15676162
98SA1_27219007_Chip-Seq_Bcells_Human1.15554385
99P300_27268052_Chip-Seq_Bcells_Human1.15496297
100* GATA3_21867929_ChIP-Seq_CD8_Mouse1.14689166
101RUNX2_22187159_ChIP-Seq_PCA_Human1.14185049
102P68_20966046_ChIP-Seq_HELA_Human1.13709361
103PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.13692521
104P53_21459846_ChIP-Seq_SAOS-2_Human1.13181419
105NFIB_24661679_ChIP-Seq_LUNG_Mouse1.12799370
106* NFYA_21822215_ChIP-Seq_K562_Human1.12702483
107SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.11821473
108* SOX2_19829295_ChIP-Seq_ESCs_Human1.11249379
109* NANOG_19829295_ChIP-Seq_ESCs_Human1.11249379
110ESET_19884257_ChIP-Seq_ESCs_Mouse1.10987145
111KLF5_20875108_ChIP-Seq_MESCs_Mouse1.10464205
112* CRX_20693478_ChIP-Seq_RETINA_Mouse1.10151435
113RUNX_20019798_ChIP-Seq_JUKART_Human1.09824464
114BMI1_23680149_ChIP-Seq_NPCS_Mouse1.09642401
115SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.08632888
116EP300_21415370_ChIP-Seq_HL-1_Mouse1.08352589
117TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08071776
118POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.08071776
119LXR_22292898_ChIP-Seq_THP-1_Human1.07970540
120JARID2_20075857_ChIP-Seq_MESCs_Mouse1.07162505
121P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.07039280
122BP1_19119308_ChIP-ChIP_Hs578T_Human1.05836745
123* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.05741693
124ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.04555935
125RNF2_27304074_Chip-Seq_NSC_Mouse1.04036205
126TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03661169
127MYC_27129775_Chip-Seq_CORNEA_Mouse1.03436472
128CEBPB_22108803_ChIP-Seq_LS180_Human1.02770581
129GATA1_19941827_ChIP-Seq_MEL86_Mouse1.02379076
130* GATA6_21074721_ChIP-Seq_CACO-2_Human1.02280943
131PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.02031972
132SMAD4_21741376_ChIP-Seq_HESCs_Human1.01877231
133SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01560302
134FLI1_21867929_ChIP-Seq_TH2_Mouse1.00814114
135SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.00753656
136NANOG_20526341_ChIP-Seq_ESCs_Human1.00029897
137AR_21572438_ChIP-Seq_LNCaP_Human0.99889734
138PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99880199
139* CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.99345986
140* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.98801142
141EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.98357751
142CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98328377
143* NANOG_18555785_Chip-Seq_ESCs_Mouse0.98160845
144SPI1_26923725_Chip-Seq_HPCs_Mouse0.97274582
145GATA3_21867929_ChIP-Seq_TH1_Mouse0.96757995
146STAT3_18555785_ChIP-Seq_MESCs_Mouse0.96742336
147RUNX1_26923725_Chip-Seq_HPCs_Mouse0.96637382
148* OCT4_18555785_Chip-Seq_ESCs_Mouse0.96470089
149CTCF_27219007_Chip-Seq_Bcells_Human0.95880824
150KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.94280947
151* NFYB_21822215_ChIP-Seq_K562_Human0.94010060
152JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.93396814
153SUZ12_27294783_Chip-Seq_ESCs_Mouse0.93286154
154SOX11_22085726_ChIP-Seq_ESNs_Mouse0.92036477
155OCT1_27270436_Chip-Seq_PROSTATE_Human0.91332494
156TBL1_22424771_ChIP-Seq_293T_Human0.90917191
157* P53_22387025_ChIP-Seq_ESCs_Mouse0.90108224
158EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.89662726
159MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.88994004
160* EZH2_27294783_Chip-Seq_NPCs_Mouse0.88528748
161* KLF4_18555785_Chip-Seq_ESCs_Mouse0.88064414
162* OCT4_21477851_ChIP-Seq_ESCs_Mouse0.87895356
163CDX2_19796622_ChIP-Seq_MESCs_Mouse0.87866488
164* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.87492211
165SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.87184287
166YY1_22570637_ChIP-Seq_MALME-3M_Human0.86572011
167MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.86054535
168MYC_19829295_ChIP-Seq_ESCs_Human0.85938776
169SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.84816502

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive4.87465774
2MP0005377_hearing/vestibular/ear_phenot4.33862747
3MP0003878_abnormal_ear_physiology4.33862747
4MP0001929_abnormal_gametogenesis4.20484682
5MP0003646_muscle_fatigue3.90209951
6MP0000566_synostosis3.25213678
7MP0003283_abnormal_digestive_organ3.14113415
8MP0004145_abnormal_muscle_electrophysio3.04936451
9MP0005670_abnormal_white_adipose2.82518318
10MP0000751_myopathy2.76062197
11MP0004233_abnormal_muscle_weight2.64463598
12MP0002161_abnormal_fertility/fecundity2.57006295
13MP0000749_muscle_degeneration2.53071473
14MP0002210_abnormal_sex_determination2.40676088
15MP0002837_dystrophic_cardiac_calcinosis2.38299225
16MP0008877_abnormal_DNA_methylation2.37990101
17MP0001348_abnormal_lacrimal_gland2.34748396
18MP0004036_abnormal_muscle_relaxation2.25453120
19MP0001145_abnormal_male_reproductive2.19754585
20MP0001501_abnormal_sleep_pattern2.18655448
21MP0002822_catalepsy2.17220910
22MP0005410_abnormal_fertilization13.1364041
23MP0002269_muscular_atrophy1.99950739
24MP0000678_abnormal_parathyroid_gland1.88318799
25MP0000653_abnormal_sex_gland1.84067868
26MP0000569_abnormal_digit_pigmentation1.82139240
27MP0005423_abnormal_somatic_nervous1.80196969
28MP0004084_abnormal_cardiac_muscle1.79685548
29MP0002653_abnormal_ependyma_morphology1.79504619
30MP0002106_abnormal_muscle_physiology1.77119591
31MP0001486_abnormal_startle_reflex1.75748361
32MP0004087_abnormal_muscle_fiber1.74679604
33MP0002132_abnormal_respiratory_system1.70076225
34MP0004215_abnormal_myocardial_fiber1.70009477
35MP0000372_irregular_coat_pigmentation1.57479932
36MP0000759_abnormal_skeletal_muscle1.55749718
37MP0001485_abnormal_pinna_reflex1.49933275
38MP0009053_abnormal_anal_canal1.49115266
39MP0000747_muscle_weakness1.47540681
40MP0001765_abnormal_ion_homeostasis1.46480634
41MP0005330_cardiomyopathy1.46463634
42MP0005620_abnormal_muscle_contractility1.45875034
43MP0005369_muscle_phenotype1.45187099
44MP0004130_abnormal_muscle_cell1.45100685
45MP0002234_abnormal_pharynx_morphology1.43730953
46MP0000750_abnormal_muscle_regeneration1.39525371
47MP0003718_maternal_effect1.37919809
48MP0005666_abnormal_adipose_tissue1.36121358
49MP0006036_abnormal_mitochondrial_physio1.35379001
50MP0005623_abnormal_meninges_morphology1.27908507
51MP0005551_abnormal_eye_electrophysiolog1.27823694
52MP0001968_abnormal_touch/_nociception1.26695826
53MP0004742_abnormal_vestibular_system1.25818286
54MP0003950_abnormal_plasma_membrane1.25178209
55MP0004510_myositis1.24142289
56MP0000026_abnormal_inner_ear1.20746755
57MP0001963_abnormal_hearing_physiology1.17311489
58MP0002332_abnormal_exercise_endurance1.14273071
59MP0001440_abnormal_grooming_behavior1.13163165
60MP0005451_abnormal_body_composition1.11020024
61MP0003137_abnormal_impulse_conducting1.09958822
62MP0004859_abnormal_synaptic_plasticity1.07302248
63MP0005367_renal/urinary_system_phenotyp1.07007050
64MP0000516_abnormal_urinary_system1.07007050
65MP0010630_abnormal_cardiac_muscle1.05284433
66MP0004043_abnormal_pH_regulation1.02265630
67MP0005248_abnormal_Harderian_gland0.99904218
68MP0002249_abnormal_larynx_morphology0.99077191
69MP0008961_abnormal_basal_metabolism0.98333041
70MP0008569_lethality_at_weaning0.96058202
71MP0000003_abnormal_adipose_tissue0.95347679
72MP0002972_abnormal_cardiac_muscle0.94526684
73MP0005379_endocrine/exocrine_gland_phen0.94400131
74MP0004085_abnormal_heartbeat0.93851549
75MP0002067_abnormal_sensory_capabilities0.93369979
76MP0005647_abnormal_sex_gland0.92433132
77MP0002108_abnormal_muscle_morphology0.89036906
78MP0002160_abnormal_reproductive_system0.88838800
79MP0002735_abnormal_chemical_nociception0.88309373
80MP0006138_congestive_heart_failure0.88290809
81MP0004484_altered_response_of0.84005157
82MP0002229_neurodegeneration0.82027614
83MP0002733_abnormal_thermal_nociception0.80238827
84MP0004142_abnormal_muscle_tone0.78565959
85MP0006035_abnormal_mitochondrial_morpho0.77940074
86MP0000681_abnormal_thyroid_gland0.75584412
87MP0001346_abnormal_lacrimal_gland0.74643362
88MP0002572_abnormal_emotion/affect_behav0.74425051
89MP0002557_abnormal_social/conspecific_i0.74323091
90MP0005385_cardiovascular_system_phenoty0.72489148
91MP0001544_abnormal_cardiovascular_syste0.72489148
92MP0001299_abnormal_eye_distance/0.72265230
93MP0003011_delayed_dark_adaptation0.71669389
94MP0009046_muscle_twitch0.71468937
95MP0005310_abnormal_salivary_gland0.71268754
96MP0001666_abnormal_nutrient_absorption0.70991586
97MP0000955_abnormal_spinal_cord0.70356020
98MP0001984_abnormal_olfaction0.69724496
99MP0008775_abnormal_heart_ventricle0.69678334
100MP0006276_abnormal_autonomic_nervous0.69236265
101MP0003638_abnormal_response/metabolism_0.68337890
102MP0004134_abnormal_chest_morphology0.66623515
103MP0006072_abnormal_retinal_apoptosis0.65063498
104MP0002971_abnormal_brown_adipose0.63850739
105MP0000733_abnormal_muscle_development0.63827161
106MP0005266_abnormal_metabolism0.62370095
107MP0003221_abnormal_cardiomyocyte_apopto0.61653727
108MP0003045_fibrosis0.61491952
109MP0001879_abnormal_lymphatic_vessel0.60804964
110MP0005636_abnormal_mineral_homeostasis0.60642657
111MP0002736_abnormal_nociception_after0.59549521
112MP0009745_abnormal_behavioral_response0.59477550
113MP0002734_abnormal_mechanical_nocicepti0.58821869
114MP0003936_abnormal_reproductive_system0.58348823
115MP0002282_abnormal_trachea_morphology0.58166787
116MP0002064_seizures0.57888445
117MP0005595_abnormal_vascular_smooth0.57362151
118MP0005084_abnormal_gallbladder_morpholo0.56729717
119MP0002272_abnormal_nervous_system0.55730695
120MP0010030_abnormal_orbit_morphology0.55555605
121MP0005375_adipose_tissue_phenotype0.55513114
122MP0002102_abnormal_ear_morphology0.55471898
123MP0004270_analgesia0.54950030
124MP0005395_other_phenotype0.52759868
125MP0000631_abnormal_neuroendocrine_gland0.52137272
126MP0000462_abnormal_digestive_system0.50934772
127MP0008789_abnormal_olfactory_epithelium0.49831820
128MP0003880_abnormal_central_pattern0.48853155
129MP0001905_abnormal_dopamine_level0.48018029
130MP0004133_heterotaxia0.47960281
131MP0001970_abnormal_pain_threshold0.47908654
132MP0003635_abnormal_synaptic_transmissio0.47095301
133MP0000534_abnormal_ureter_morphology0.45842521
134MP0005319_abnormal_enzyme/_coenzyme0.45234730
135MP0001661_extended_life_span0.45192247
136MP0002127_abnormal_cardiovascular_syste0.41446461
137MP0000266_abnormal_heart_morphology0.40680042
138MP0003959_abnormal_lean_body0.40067840
139MP0003890_abnormal_embryonic-extraembry0.38220393
140MP0009250_abnormal_appendicular_skeleto0.38057216
141MP0005253_abnormal_eye_physiology0.37437044
142MP0009115_abnormal_fat_cell0.35650205
143MP0003119_abnormal_digestive_system0.35626986
144MP0010386_abnormal_urinary_bladder0.35107402
145MP0002114_abnormal_axial_skeleton0.34267562
146MP0008995_early_reproductive_senescence0.34195143
147MP0005389_reproductive_system_phenotype0.34150253
148MP0004019_abnormal_vitamin_homeostasis0.32798433
149MP0005187_abnormal_penis_morphology0.31646184
150MP0003172_abnormal_lysosome_physiology0.30543878
151MP0003115_abnormal_respiratory_system0.30130370
152MP0005535_abnormal_body_temperature0.29730072
153MP0002909_abnormal_adrenal_gland0.27792847
154MP0002009_preneoplasia0.27551906
155MP0002752_abnormal_somatic_nervous0.27464267
156MP0000230_abnormal_systemic_arterial0.26569113
157MP0003879_abnormal_hair_cell0.26446561
158MP0003828_pulmonary_edema0.25058887
159MP0004858_abnormal_nervous_system0.24410088
160MP0003948_abnormal_gas_homeostasis0.24367414
161MP0000358_abnormal_cell_content/0.24132054
162MP0002932_abnormal_joint_morphology0.23871144
163MP0001324_abnormal_eye_pigmentation0.23822707
164MP0000049_abnormal_middle_ear0.23681904

Predicted human phenotypes

RankGene SetZ-score
1Severe visual impairment (HP:0001141)8.06863518
2Abnormal respiratory epithelium morphology (HP:0012253)7.89352129
3Abnormal respiratory motile cilium morphology (HP:0005938)7.89352129
4Abnormal respiratory motile cilium physiology (HP:0012261)7.87476931
5Abnormal ciliary motility (HP:0012262)6.28746886
6Rhinitis (HP:0012384)6.18915544
7Chronic bronchitis (HP:0004469)6.06085648
8Infertility (HP:0000789)5.79227040
9Bell-shaped thorax (HP:0001591)5.77954543
10Nasal polyposis (HP:0100582)5.28915338
11Exercise-induced myalgia (HP:0003738)5.01050814
12Abnormality of the nasal mucosa (HP:0000433)4.43766216
13Bony spicule pigmentary retinopathy (HP:0007737)4.26966791
14Exercise-induced muscle cramps (HP:0003710)4.20751872
15Attenuation of retinal blood vessels (HP:0007843)4.12265542
16Hypoplastic ischia (HP:0003175)4.00120828
17Hyporeflexia of lower limbs (HP:0002600)3.83808200
18Male infertility (HP:0003251)3.78917808
19Chronic hepatic failure (HP:0100626)3.66658794
20Abnormality of the ischium (HP:0003174)3.63759269
21Recurrent corneal erosions (HP:0000495)3.61187510
22Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.55855283
23Myoglobinuria (HP:0002913)3.53848329
24Aplasia/Hypoplasia of the earlobes (HP:0009906)3.48934163
25Facial shape deformation (HP:0011334)3.46619006
26Potter facies (HP:0002009)3.46619006
27Muscle fiber inclusion bodies (HP:0100299)3.44721847
28Enlarged epiphyses (HP:0010580)3.44397160
29Bronchiectasis (HP:0002110)3.42944425
30Resting tremor (HP:0002322)3.39984116
31Sensory axonal neuropathy (HP:0003390)3.38399192
32Bronchitis (HP:0012387)3.37121881
33Muscle hypertrophy of the lower extremities (HP:0008968)3.33908964
34Calf muscle hypertrophy (HP:0008981)3.33898460
35Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.32831960
36Asymmetric septal hypertrophy (HP:0001670)3.15687026
37Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.13919374
38Postural instability (HP:0002172)3.11236650
39Muscle fiber splitting (HP:0003555)3.10368916
40Abnormality of macular pigmentation (HP:0008002)3.05720213
41Nephronophthisis (HP:0000090)2.99495061
42Difficulty running (HP:0009046)2.89743448
43Spastic paraparesis (HP:0002313)2.88505744
44Mixed hearing impairment (HP:0000410)2.87339999
45Abnormal rod and cone electroretinograms (HP:0008323)2.85577219
46Nemaline bodies (HP:0003798)2.83354795
47Cone-rod dystrophy (HP:0000548)2.82071514
48Menstrual irregularities (HP:0000858)2.75294499
49Rhabdomyolysis (HP:0003201)2.72781131
50Bundle branch block (HP:0011710)2.70693379
51Abnormality of the pubic bones (HP:0003172)2.61461714
52Cerebral hypomyelination (HP:0006808)2.55286663
53Abnormal spermatogenesis (HP:0008669)2.54553657
54Renal dysplasia (HP:0000110)2.53582322
55Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.50862512
56Absent epiphyses (HP:0010577)2.50862512
57Type 1 muscle fiber predominance (HP:0003803)2.47274653
58Amelogenesis imperfecta (HP:0000705)2.43533985
59Sudden death (HP:0001699)2.42912997
60Difficulty climbing stairs (HP:0003551)2.41475492
61Recurrent otitis media (HP:0000403)2.41366457
62Ventricular tachycardia (HP:0004756)2.37949938
63Abnormality of the calf musculature (HP:0001430)2.36299047
64Aplasia involving bones of the extremities (HP:0009825)2.33327061
65Aplasia involving bones of the upper limbs (HP:0009823)2.33327061
66Aplasia of the phalanges of the hand (HP:0009802)2.33327061
67Abnormality of the renal medulla (HP:0100957)2.32078277
68Recurrent sinusitis (HP:0011108)2.31854822
69Renal Fanconi syndrome (HP:0001994)2.27507279
70Abnormality of the costochondral junction (HP:0000919)2.27433001
71Hypoplastic left heart (HP:0004383)2.25914723
72Fatigable weakness (HP:0003473)2.25749541
73Abnormality of the neuromuscular junction (HP:0003398)2.25749541
74Partial duplication of thumb phalanx (HP:0009944)2.25262362
75Esophageal atresia (HP:0002032)2.24193745
76Hypoplasia of the thymus (HP:0000778)2.22325169
77Pancreatic fibrosis (HP:0100732)2.22035738
78Focal segmental glomerulosclerosis (HP:0000097)2.20845248
79Hyperkalemia (HP:0002153)2.19055102
80Generalized muscle weakness (HP:0003324)2.18985657
81Unilateral renal agenesis (HP:0000122)2.18863735
82Abnormality of the aortic arch (HP:0012303)2.17247337
83Impulsivity (HP:0100710)2.16540389
84Hypoplastic heart (HP:0001961)2.15661848
85EMG: myopathic abnormalities (HP:0003458)2.13922886
86Abnormality of incisor morphology (HP:0011063)2.13583981
87Congenital sensorineural hearing impairment (HP:0008527)2.13078331
88Amblyopia (HP:0000646)2.12321691
89Abnormality of potassium homeostasis (HP:0011042)2.12024337
90Hypoalphalipoproteinemia (HP:0003233)2.10568146
91Increased connective tissue (HP:0009025)2.08501422
92Increased purine levels (HP:0004368)2.08096848
93Hyperuricemia (HP:0002149)2.08096848
94Tubulointerstitial fibrosis (HP:0005576)2.06235160
95Abnormality of dental color (HP:0011073)2.05117488
96Muscle stiffness (HP:0003552)2.05009043
97Generalized aminoaciduria (HP:0002909)2.03514533
98Easy fatigability (HP:0003388)2.02751981
99Occipital encephalocele (HP:0002085)2.02400551
100Medial flaring of the eyebrow (HP:0010747)2.02308426
101Abnormal drinking behavior (HP:0030082)2.01414617
102Polydipsia (HP:0001959)2.01414617
103Progressive cerebellar ataxia (HP:0002073)2.00405835
104Dynein arm defect of respiratory motile cilia (HP:0012255)11.5491180
105Absent/shortened dynein arms (HP:0200106)11.5491180
106Respiratory insufficiency due to defective ciliary clearance (HP:0200073)11.0700467
107EMG: neuropathic changes (HP:0003445)1.98533759
108Alacrima (HP:0000522)1.94929324
109Gowers sign (HP:0003391)1.94489079
110Synostosis of carpal bones (HP:0005048)1.93834428
111Partial duplication of the phalanx of hand (HP:0009999)1.92195695
112Tubulointerstitial nephritis (HP:0001970)1.91467283
113Insulin-resistant diabetes mellitus (HP:0000831)1.91406945
114Abnormality of the epiphysis of the femoral head (HP:0010574)1.91065551
115Glomerulosclerosis (HP:0000096)1.90978365
116Tubular atrophy (HP:0000092)1.90892946
117Abnormality of the dental pulp (HP:0006479)1.87259995
118Portal hypertension (HP:0001409)1.87002858
119Failure to thrive in infancy (HP:0001531)1.86415548
120Ulnar deviation of the wrist (HP:0003049)1.86190445
121Bulbous nose (HP:0000414)1.84799590
122Abnormality of renal excretion (HP:0011036)1.84453254
123Bulbar palsy (HP:0001283)1.83666791
124Decreased central vision (HP:0007663)1.82556757
125Distal arthrogryposis (HP:0005684)1.81178295
126Abnormality of the femoral head (HP:0003368)1.81037315
127Abnormality of the left ventricular outflow tract (HP:0011103)1.80229198
128Subaortic stenosis (HP:0001682)1.80229198
129Slow saccadic eye movements (HP:0000514)1.79936477
130Intellectual disability, moderate (HP:0002342)1.79914724
131Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.79512977
132Spastic tetraparesis (HP:0001285)1.77524563
133Gonadotropin excess (HP:0000837)1.74157689
134Areflexia of lower limbs (HP:0002522)1.69185820
135Abnormality of midbrain morphology (HP:0002418)1.68522042
136Molar tooth sign on MRI (HP:0002419)1.68522042
137Azoospermia (HP:0000027)1.68357823
138Tubulointerstitial abnormality (HP:0001969)1.64373460
139Abnormal urine output (HP:0012590)1.63955080
140Heart block (HP:0012722)1.60863128
141Weak cry (HP:0001612)1.59241178
142Abnormal gallbladder physiology (HP:0012438)1.58713354
143Cholecystitis (HP:0001082)1.58713354
144Decreased electroretinogram (ERG) amplitude (HP:0000654)1.58382103
145Nonprogressive disorder (HP:0003680)1.58122095
146Recurrent bronchitis (HP:0002837)1.57812703
147Dyschromatopsia (HP:0007641)1.55895540
148Atrial fibrillation (HP:0005110)1.55354534
149Myotonia (HP:0002486)1.55298505
150Abnormality of chloride homeostasis (HP:0011422)1.54657531
151Neck muscle weakness (HP:0000467)1.52199445
152Lipoatrophy (HP:0100578)1.50511688
153Stage 5 chronic kidney disease (HP:0003774)1.50443024
154Heterotopia (HP:0002282)1.50436534
155Round ear (HP:0100830)1.49736100
156Short ribs (HP:0000773)1.48920153
157Abnormal atrioventricular conduction (HP:0005150)1.48449882
158Ventricular fibrillation (HP:0001663)1.44928855
159Muscular dystrophy (HP:0003560)1.44225581
160Polyuria (HP:0000103)1.43477203
161Congenital malformation of the right heart (HP:0011723)1.43421705
162Double outlet right ventricle (HP:0001719)1.43421705
163Distal lower limb muscle weakness (HP:0009053)1.42451693
164Left ventricular hypertrophy (HP:0001712)1.41746809
165Gout (HP:0001997)1.39484748
166Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.39240783
167Increased variability in muscle fiber diameter (HP:0003557)1.39046023
168Myopathic facies (HP:0002058)1.37784131
169Primary atrial arrhythmia (HP:0001692)1.37695479
170Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.37418685

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK47.52811435
2PDK37.52811435
3PLK46.70343793
4PDK24.93293880
5TESK14.15254899
6ICK4.10885432
7MAP4K23.91070097
8PRKD33.38770123
9STK393.25075849
10OBSCN2.84736549
11FGFR22.76715841
12WNK42.74104676
13PLK22.60545159
14BRD42.22198279
15TTN2.14488134
16PNCK1.86537127
17PHKG11.84095730
18PHKG21.84095730
19STK381.74386939
20DYRK1B1.53202822
21WNK11.51109394
22PTK2B1.43008678
23MAP3K121.40608153
24LMTK21.39647605
25MST1R1.28962417
26STK38L1.27732970
27PINK11.26115777
28MAP3K61.23339947
29MUSK1.17318394
30TAOK11.05498566
31LATS11.05103831
32PDK11.02033684
33MAP3K111.01661440
34CAMK1G0.96176568
35OXSR10.95549615
36CDK120.95402838
37AKT30.94084316
38TYRO30.89452545
39PIK3CG0.89232999
40CDK70.89008670
41MARK10.80735473
42KSR20.79981864
43ERN10.77148739
44CAMK1D0.74775008
45CDK30.74223867
46DMPK0.73261262
47NEK20.71908758
48BCKDK0.71883563
49MAPK150.67359891
50PDPK10.66962073
51MAP2K60.64460844
52PRKAA10.63070411
53DYRK30.61186837
54GRK10.60907708
55PKN10.54819998
56ROCK10.53661891
57NEK60.51664480
58STK30.50791885
59ERBB30.50449871
60EPHA30.50214430
61GRK70.48918329
62STK240.46100762
63MAP2K20.45207742
64SIK20.44037335
65TESK20.43589044
66LATS20.43485118
67SGK4940.42427961
68SGK2230.42427961
69PRKCH0.41560942
70CHEK20.40836859
71IRAK10.40582065
72CASK0.39833958
73ABL20.38057797
74FGFR10.37600856
75RPS6KA20.36557878
76MTOR0.36255988
77MAP3K20.35598110
78UHMK10.34444038
79GRK50.33861313
80MAP3K70.32828374
81CDK190.31999476
82PIK3CA0.31762433
83TAOK30.31603215
84MAP2K40.31597583
85MAP3K10.30386877
86PDGFRA0.29709882
87CAMK40.29616857
88GSK3B0.29321736
89PRKAA20.26654375
90MYLK0.25855709
91CHUK0.25770134
92MAP2K10.25707748
93NTRK30.24667752
94RIPK10.24619501
95TLK10.24296067
96MAPK120.23939104
97MAPK70.23215421
98SGK20.22464830
99TTK0.21240792
100PRKCB0.20452860
101KDR0.20314298
102MAPK10.20107274
103PRKG20.19919030
104NTRK20.19553091
105CDK20.19542283
106MAPK80.19471325
107DDR20.18177867
108BRSK20.17992078
109NEK10.17628279
110PRKACG0.17569037
111NME10.16804610
112BMPR1B0.16315407
113SGK10.15503811
114MARK20.15326102
115TXK0.15160215
116TIE10.14975524
117CAMKK10.14971966
118PRKCQ0.14929579
119MAP2K70.14631093
120PRKG10.14474346
121PRKCG0.14395022
122PRKACA0.14173502
123MAP3K40.13932643
124EPHB10.13458829
125CDK10.13408177
126PRKACB0.13263220
127ERBB20.12819849
128NUAK10.12395025
129PASK0.12149165
130CAMK2A0.12130357
131PDGFRB0.11952487
132MAP3K90.11840761
133TNK20.10561036
134CDC42BPA0.10553138
135RPS6KA30.10227412
136CHEK10.09878486
137TRIB30.09460685
138GSK3A0.09139387
139RIPK40.09104314
140CAMK2D0.08873718
141RPS6KA10.08732601
142MAP3K50.08572328
143MAP2K30.07984975
144CAMK10.07578620
145WNK30.07449505
146MATK0.07335430
147PAK20.06969870
148MAP3K30.06651326
149PAK10.06527973
150PRKCZ0.06525906
151STK110.06334234
152INSRR0.05910376

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000727.23813480
2Propanoate metabolism_Homo sapiens_hsa006403.91490891
3Fatty acid biosynthesis_Homo sapiens_hsa000613.82996923
4Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.81165716
5Olfactory transduction_Homo sapiens_hsa047403.62221217
6Pyruvate metabolism_Homo sapiens_hsa006203.27492666
7Cardiac muscle contraction_Homo sapiens_hsa042602.75739977
8Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.56367464
9Fatty acid degradation_Homo sapiens_hsa000712.48658731
10Vitamin B6 metabolism_Homo sapiens_hsa007502.44969510
11Glucagon signaling pathway_Homo sapiens_hsa049222.41189907
12alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.38769196
13Fatty acid metabolism_Homo sapiens_hsa012122.17348703
14Linoleic acid metabolism_Homo sapiens_hsa005912.11862942
15Carbon metabolism_Homo sapiens_hsa012002.10760467
16Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.00794176
17PPAR signaling pathway_Homo sapiens_hsa033201.85934349
18Primary bile acid biosynthesis_Homo sapiens_hsa001201.83908256
19Antigen processing and presentation_Homo sapiens_hsa046121.77071914
20Fructose and mannose metabolism_Homo sapiens_hsa000511.76876839
21Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.64505044
22Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.62854811
23Autoimmune thyroid disease_Homo sapiens_hsa053201.62681040
24Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.59986087
25Graft-versus-host disease_Homo sapiens_hsa053321.55441006
26Allograft rejection_Homo sapiens_hsa053301.55440640
27Dorso-ventral axis formation_Homo sapiens_hsa043201.55092215
28Glycerolipid metabolism_Homo sapiens_hsa005611.48290104
29Glycosaminoglycan degradation_Homo sapiens_hsa005311.47901187
30Carbohydrate digestion and absorption_Homo sapiens_hsa049731.46241200
31Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.45404339
32Type I diabetes mellitus_Homo sapiens_hsa049401.44673681
33Phenylalanine metabolism_Homo sapiens_hsa003601.42848971
34Maturity onset diabetes of the young_Homo sapiens_hsa049501.40770476
35Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.35828170
36Other glycan degradation_Homo sapiens_hsa005111.31941255
37Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.31371311
38Huntingtons disease_Homo sapiens_hsa050161.29122667
39Dilated cardiomyopathy_Homo sapiens_hsa054141.28737352
40Biosynthesis of amino acids_Homo sapiens_hsa012301.26146844
41Pentose phosphate pathway_Homo sapiens_hsa000301.24024091
42Nitrogen metabolism_Homo sapiens_hsa009101.20615044
43Phototransduction_Homo sapiens_hsa047441.17948784
44Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.16391331
45Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.15281612
46Selenocompound metabolism_Homo sapiens_hsa004501.13410281
47Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.13326794
48Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.12906624
49Mineral absorption_Homo sapiens_hsa049781.12780711
50Glycerophospholipid metabolism_Homo sapiens_hsa005641.09204110
51Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.09045600
52Adipocytokine signaling pathway_Homo sapiens_hsa049201.07249215
53Type II diabetes mellitus_Homo sapiens_hsa049301.06658993
54Nicotine addiction_Homo sapiens_hsa050331.02601346
55Sulfur relay system_Homo sapiens_hsa041221.02274938
562-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.00675699
57Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.98710396
58Calcium signaling pathway_Homo sapiens_hsa040200.95684885
59RNA transport_Homo sapiens_hsa030130.95473151
60Renin secretion_Homo sapiens_hsa049240.94309790
61Cysteine and methionine metabolism_Homo sapiens_hsa002700.93094143
62AMPK signaling pathway_Homo sapiens_hsa041520.92386978
63cGMP-PKG signaling pathway_Homo sapiens_hsa040220.91531838
64Circadian entrainment_Homo sapiens_hsa047130.90579799
65Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.90308974
66Basal transcription factors_Homo sapiens_hsa030220.89196639
67Renin-angiotensin system_Homo sapiens_hsa046140.83983357
68Glutamatergic synapse_Homo sapiens_hsa047240.83596662
69Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.82755537
70Arginine and proline metabolism_Homo sapiens_hsa003300.80721976
71Ether lipid metabolism_Homo sapiens_hsa005650.79707999
72Oocyte meiosis_Homo sapiens_hsa041140.79066369
73Amphetamine addiction_Homo sapiens_hsa050310.76916690
74Fat digestion and absorption_Homo sapiens_hsa049750.76644445
75Serotonergic synapse_Homo sapiens_hsa047260.75719267
76Collecting duct acid secretion_Homo sapiens_hsa049660.72794584
77Pentose and glucuronate interconversions_Homo sapiens_hsa000400.72427359
78Circadian rhythm_Homo sapiens_hsa047100.71436789
79Steroid hormone biosynthesis_Homo sapiens_hsa001400.70941665
80Gastric acid secretion_Homo sapiens_hsa049710.70921206
81Aldosterone synthesis and secretion_Homo sapiens_hsa049250.70885990
82Insulin secretion_Homo sapiens_hsa049110.70008260
83Insulin resistance_Homo sapiens_hsa049310.69568712
84Sulfur metabolism_Homo sapiens_hsa009200.69044388
85Starch and sucrose metabolism_Homo sapiens_hsa005000.68721542
86MAPK signaling pathway_Homo sapiens_hsa040100.68438947
87Glutathione metabolism_Homo sapiens_hsa004800.67321680
88Bile secretion_Homo sapiens_hsa049760.64251261
89Influenza A_Homo sapiens_hsa051640.63688211
90Oxidative phosphorylation_Homo sapiens_hsa001900.63427033
91Vascular smooth muscle contraction_Homo sapiens_hsa042700.63329514
92ABC transporters_Homo sapiens_hsa020100.63239114
93Morphine addiction_Homo sapiens_hsa050320.62437084
94Arachidonic acid metabolism_Homo sapiens_hsa005900.61362357
95Protein digestion and absorption_Homo sapiens_hsa049740.61332539
96Insulin signaling pathway_Homo sapiens_hsa049100.58346917
97Tight junction_Homo sapiens_hsa045300.58241748
98Alzheimers disease_Homo sapiens_hsa050100.56103889
99Central carbon metabolism in cancer_Homo sapiens_hsa052300.54544862
100Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.54520317
101Thyroid hormone synthesis_Homo sapiens_hsa049180.53797878
102Salivary secretion_Homo sapiens_hsa049700.53758128
103Hedgehog signaling pathway_Homo sapiens_hsa043400.52248991
104Synaptic vesicle cycle_Homo sapiens_hsa047210.51769833
105Butanoate metabolism_Homo sapiens_hsa006500.51534054
106Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.51426531
107Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.51175670
108Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.50592989
109Metabolic pathways_Homo sapiens_hsa011000.49788251
110Fatty acid elongation_Homo sapiens_hsa000620.49444079
111Thyroid hormone signaling pathway_Homo sapiens_hsa049190.48490302
112Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.48427288
113Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.48345895
114Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.47284650
115Pancreatic secretion_Homo sapiens_hsa049720.47130560
116Tryptophan metabolism_Homo sapiens_hsa003800.46404507
117Parkinsons disease_Homo sapiens_hsa050120.45708473
118Tyrosine metabolism_Homo sapiens_hsa003500.45143117
119Retinol metabolism_Homo sapiens_hsa008300.44589262
120cAMP signaling pathway_Homo sapiens_hsa040240.43407682
121Oxytocin signaling pathway_Homo sapiens_hsa049210.41985801
122Histidine metabolism_Homo sapiens_hsa003400.41546957
123Purine metabolism_Homo sapiens_hsa002300.40074257
124Fanconi anemia pathway_Homo sapiens_hsa034600.39030211
125Inositol phosphate metabolism_Homo sapiens_hsa005620.38289464
126Estrogen signaling pathway_Homo sapiens_hsa049150.37475954
127Peroxisome_Homo sapiens_hsa041460.35447369
128Galactose metabolism_Homo sapiens_hsa000520.35418419
129Taste transduction_Homo sapiens_hsa047420.34950594
130mRNA surveillance pathway_Homo sapiens_hsa030150.33617912
131Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.32705762
132Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.30049920
133Viral myocarditis_Homo sapiens_hsa054160.28328452
134Chemical carcinogenesis_Homo sapiens_hsa052040.28101891
135Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.28089222
136ECM-receptor interaction_Homo sapiens_hsa045120.27712066
137Endocytosis_Homo sapiens_hsa041440.25183468
138Longevity regulating pathway - mammal_Homo sapiens_hsa042110.24638900
139Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.24318233

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