

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | regulation of short-term neuronal synaptic plasticity (GO:0048172) | 6.08538068 |
| 2 | synaptic vesicle maturation (GO:0016188) | 6.03761176 |
| 3 | synaptic vesicle exocytosis (GO:0016079) | 5.81360390 |
| 4 | positive regulation of calcium ion-dependent exocytosis (GO:0045956) | 5.64719241 |
| 5 | glutamate secretion (GO:0014047) | 5.63912222 |
| 6 | vocalization behavior (GO:0071625) | 5.52854024 |
| 7 | locomotory exploration behavior (GO:0035641) | 5.42660529 |
| 8 | positive regulation of excitatory postsynaptic membrane potential (GO:2000463) | 5.40291537 |
| 9 | neuron cell-cell adhesion (GO:0007158) | 5.19108205 |
| 10 | regulation of synaptic vesicle exocytosis (GO:2000300) | 5.15789337 |
| 11 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act | 5.05849731 |
| 12 | synaptic vesicle docking involved in exocytosis (GO:0016081) | 4.87738777 |
| 13 | protein localization to synapse (GO:0035418) | 4.85198481 |
| 14 | establishment of mitochondrion localization (GO:0051654) | 4.81083185 |
| 15 | layer formation in cerebral cortex (GO:0021819) | 4.77990789 |
| 16 | regulation of glutamate receptor signaling pathway (GO:1900449) | 4.70908055 |
| 17 | regulation of synaptic vesicle transport (GO:1902803) | 4.59496322 |
| 18 | neurotransmitter secretion (GO:0007269) | 4.58367526 |
| 19 | exploration behavior (GO:0035640) | 4.44935496 |
| 20 | dendritic spine morphogenesis (GO:0060997) | 4.43047564 |
| 21 | regulation of long-term neuronal synaptic plasticity (GO:0048169) | 4.35331237 |
| 22 | neuronal ion channel clustering (GO:0045161) | 4.33628601 |
| 23 | proline transport (GO:0015824) | 4.29523326 |
| 24 | mitochondrion transport along microtubule (GO:0047497) | 4.20886096 |
| 25 | establishment of mitochondrion localization, microtubule-mediated (GO:0034643) | 4.20886096 |
| 26 | regulation of neuronal synaptic plasticity (GO:0048168) | 4.20541348 |
| 27 | regulation of synapse structural plasticity (GO:0051823) | 4.18559856 |
| 28 | ionotropic glutamate receptor signaling pathway (GO:0035235) | 4.15382675 |
| 29 | cerebral cortex radially oriented cell migration (GO:0021799) | 4.08288623 |
| 30 | neuron recognition (GO:0008038) | 4.06626676 |
| 31 | regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310) | 4.01564712 |
| 32 | gamma-aminobutyric acid transport (GO:0015812) | 3.99268941 |
| 33 | axonal fasciculation (GO:0007413) | 3.92797326 |
| 34 | neurotransmitter-gated ion channel clustering (GO:0072578) | 3.82293034 |
| 35 | synaptic transmission, glutamatergic (GO:0035249) | 3.77874265 |
| 36 | postsynaptic membrane organization (GO:0001941) | 3.76744227 |
| 37 | neuronal action potential propagation (GO:0019227) | 3.76121513 |
| 38 | neurotransmitter transport (GO:0006836) | 3.73212420 |
| 39 | glutamate receptor signaling pathway (GO:0007215) | 3.73141272 |
| 40 | axon ensheathment in central nervous system (GO:0032291) | 3.71357058 |
| 41 | central nervous system myelination (GO:0022010) | 3.71357058 |
| 42 | activation of protein kinase A activity (GO:0034199) | 3.69435841 |
| 43 | neuron-neuron synaptic transmission (GO:0007270) | 3.67182992 |
| 44 | positive regulation of membrane potential (GO:0045838) | 3.64129316 |
| 45 | spinal cord development (GO:0021510) | 3.63018070 |
| 46 | dendrite morphogenesis (GO:0048813) | 3.59633522 |
| 47 | regulation of excitatory postsynaptic membrane potential (GO:0060079) | 3.57115778 |
| 48 | positive regulation of synapse maturation (GO:0090129) | 3.56383018 |
| 49 | central nervous system neuron axonogenesis (GO:0021955) | 3.53360275 |
| 50 | long-term memory (GO:0007616) | 3.51906548 |
| 51 | regulation of neurotransmitter levels (GO:0001505) | 3.50842189 |
| 52 | auditory behavior (GO:0031223) | 3.48976743 |
| 53 | regulation of inhibitory postsynaptic membrane potential (GO:0060080) | 3.48381935 |
| 54 | axon extension (GO:0048675) | 3.45657029 |
| 55 | regulation of postsynaptic membrane potential (GO:0060078) | 3.45656473 |
| 56 | membrane depolarization during cardiac muscle cell action potential (GO:0086012) | 3.45178741 |
| 57 | retinal ganglion cell axon guidance (GO:0031290) | 3.43835540 |
| 58 | cerebellar Purkinje cell differentiation (GO:0021702) | 3.41233825 |
| 59 | regulation of neurotransmitter secretion (GO:0046928) | 3.40482387 |
| 60 | cell migration in hindbrain (GO:0021535) | 3.40208450 |
| 61 | negative regulation of microtubule polymerization (GO:0031115) | 3.36719684 |
| 62 | synaptic vesicle endocytosis (GO:0048488) | 3.36260554 |
| 63 | negative regulation of cytosolic calcium ion concentration (GO:0051481) | 3.35578427 |
| 64 | cellular potassium ion homeostasis (GO:0030007) | 3.26954883 |
| 65 | regulation of synaptic plasticity (GO:0048167) | 3.26862300 |
| 66 | adult walking behavior (GO:0007628) | 3.26856726 |
| 67 | behavioral response to nicotine (GO:0035095) | 3.26756096 |
| 68 | presynaptic membrane assembly (GO:0097105) | 3.25917887 |
| 69 | positive regulation of potassium ion transmembrane transporter activity (GO:1901018) | 3.25595521 |
| 70 | nonmotile primary cilium assembly (GO:0035058) | 3.25532655 |
| 71 | pyrimidine nucleobase catabolic process (GO:0006208) | 3.24949546 |
| 72 | gamma-aminobutyric acid signaling pathway (GO:0007214) | 3.21402119 |
| 73 | central nervous system projection neuron axonogenesis (GO:0021952) | 3.19991003 |
| 74 | response to auditory stimulus (GO:0010996) | 3.19099404 |
| 75 | regulation of dendritic spine morphogenesis (GO:0061001) | 3.18197125 |
| 76 | positive regulation of synaptic transmission, GABAergic (GO:0032230) | 3.18152369 |
| 77 | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339) | 3.18145160 |
| 78 | regulation of vesicle fusion (GO:0031338) | 3.17874292 |
| 79 | negative regulation of axonogenesis (GO:0050771) | 3.17189555 |
| 80 | regulation of respiratory gaseous exchange by neurological system process (GO:0002087) | 3.17024315 |
| 81 | synapse assembly (GO:0007416) | 3.16928807 |
| 82 | prepulse inhibition (GO:0060134) | 3.16639905 |
| 83 | transmission of nerve impulse (GO:0019226) | 3.16359443 |
| 84 | neuromuscular process controlling balance (GO:0050885) | 3.15556865 |
| 85 | regulation of neurotransmitter transport (GO:0051588) | 3.14716643 |
| 86 | positive regulation of neurotransmitter secretion (GO:0001956) | 3.14405354 |
| 87 | long-term synaptic potentiation (GO:0060291) | 3.12315111 |
| 88 | cerebellar Purkinje cell layer development (GO:0021680) | 3.10913449 |
| 89 | regulation of axon extension involved in axon guidance (GO:0048841) | 3.09731912 |
| 90 | regulation of axon guidance (GO:1902667) | 3.09094878 |
| 91 | vesicle transport along microtubule (GO:0047496) | 3.08512884 |
| 92 | G-protein coupled acetylcholine receptor signaling pathway (GO:0007213) | 3.07483849 |
| 93 | negative regulation of axon extension (GO:0030517) | 3.06972993 |
| 94 | presynaptic membrane organization (GO:0097090) | 3.06135919 |
| 95 | positive regulation of neurotransmitter transport (GO:0051590) | 3.05229783 |
| 96 | organelle transport along microtubule (GO:0072384) | 3.04770139 |
| 97 | mating behavior (GO:0007617) | 3.04387537 |
| 98 | intraspecies interaction between organisms (GO:0051703) | 3.03207897 |
| 99 | social behavior (GO:0035176) | 3.03207897 |
| 100 | regulation of synaptic transmission, glutamatergic (GO:0051966) | 3.03084225 |
| 101 | membrane depolarization (GO:0051899) | 3.02858672 |
| 102 | substrate-independent telencephalic tangential interneuron migration (GO:0021843) | 3.02241620 |
| 103 | substrate-independent telencephalic tangential migration (GO:0021826) | 3.02241620 |
| 104 | cerebellar granule cell differentiation (GO:0021707) | 3.00420582 |
| 105 | mechanosensory behavior (GO:0007638) | 2.99939705 |
| 106 | negative regulation of synaptic transmission, GABAergic (GO:0032229) | 2.99768468 |
| 107 | synapse organization (GO:0050808) | 2.98836231 |
| 108 | response to histamine (GO:0034776) | 2.98379247 |
| 109 | innervation (GO:0060384) | 2.97763270 |
| 110 | establishment of nucleus localization (GO:0040023) | 2.97451507 |
| 111 | positive regulation of synaptic transmission, glutamatergic (GO:0051968) | 2.96426277 |
| 112 | clathrin coat assembly (GO:0048268) | 2.95922761 |
| 113 | membrane depolarization during action potential (GO:0086010) | 2.95322690 |
| 114 | positive regulation of synapse assembly (GO:0051965) | 2.91553085 |
| 115 | cell communication by electrical coupling involved in cardiac conduction (GO:0086064) | 2.90799950 |
| 116 | olfactory bulb development (GO:0021772) | 2.90294354 |
| 117 | sodium ion export (GO:0071436) | 2.89738796 |
| 118 | neuron projection extension (GO:1990138) | 2.89416015 |
| 119 | positive regulation of synaptic transmission, dopaminergic (GO:0032226) | 2.89069612 |
| 120 | cell communication by electrical coupling (GO:0010644) | 2.88889081 |
| 121 | synaptic vesicle transport (GO:0048489) | 2.88261777 |
| 122 | establishment of synaptic vesicle localization (GO:0097480) | 2.88261777 |
| 123 | learning (GO:0007612) | 2.88242795 |
| 124 | embryonic retina morphogenesis in camera-type eye (GO:0060059) | 2.87575781 |
| 125 | regulation of dendritic spine development (GO:0060998) | 2.87183713 |
| 126 | regulation of calcium ion-dependent exocytosis (GO:0017158) | 2.87076228 |
| 127 | membrane hyperpolarization (GO:0060081) | 2.86976521 |
| 128 | nucleobase catabolic process (GO:0046113) | 2.86143446 |
| 129 | startle response (GO:0001964) | 2.85776569 |
| 130 | neuron migration (GO:0001764) | 2.85271262 |
| 131 | limb bud formation (GO:0060174) | 2.80625812 |
| 132 | hippocampus development (GO:0021766) | 2.80094238 |
| 133 | negative regulation of dendrite development (GO:2000171) | 2.78901688 |
| 134 | regulation of respiratory system process (GO:0044065) | 2.78686404 |
| 135 | regulation of neurotransmitter uptake (GO:0051580) | 2.75676863 |
| 136 | axonogenesis (GO:0007409) | 2.69251076 |
| 137 | dendrite development (GO:0016358) | 2.68329889 |
| 138 | forebrain neuron differentiation (GO:0021879) | 2.67537191 |
| 139 | regulation of axonogenesis (GO:0050770) | 2.67496018 |
| 140 | adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191) | 2.64690365 |
| 141 | cerebral cortex cell migration (GO:0021795) | 2.64336931 |
| 142 | negative regulation of axon guidance (GO:1902668) | 2.57782903 |
| 143 | neural tube formation (GO:0001841) | 2.57150179 |
| 144 | brain morphogenesis (GO:0048854) | 2.56745928 |
| 145 | regulation of axon extension (GO:0030516) | 2.56307159 |
| 146 | regulation of extent of cell growth (GO:0061387) | 2.52288714 |
| 147 | negative regulation of neuron projection development (GO:0010977) | 2.52114991 |
| 148 | negative regulation of neurotransmitter transport (GO:0051589) | 2.51935942 |
| 149 | glycosphingolipid biosynthetic process (GO:0006688) | 2.51526341 |
| 150 | appendage development (GO:0048736) | 2.47826210 |
| 151 | limb development (GO:0060173) | 2.47826210 |
| 152 | negative regulation of axon extension involved in axon guidance (GO:0048843) | 2.47441964 |
| 153 | neuromuscular synaptic transmission (GO:0007274) | 2.45982396 |
| 154 | forebrain cell migration (GO:0021885) | 2.45904162 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EZH2_22144423_ChIP-Seq_EOC_Human | 6.16864693 |
| 2 | GBX2_23144817_ChIP-Seq_PC3_Human | 3.45242592 |
| 3 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 3.09400128 |
| 4 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 2.93499985 |
| 5 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 2.91839601 |
| 6 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 2.64077000 |
| 7 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 2.64077000 |
| 8 | REST_21632747_ChIP-Seq_MESCs_Mouse | 2.62301830 |
| 9 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 2.53516143 |
| 10 | SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 2.52509703 |
| 11 | DROSHA_22980978_ChIP-Seq_HELA_Human | 2.48395317 |
| 12 | SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 2.47751695 |
| 13 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 2.47577523 |
| 14 | MTF2_20144788_ChIP-Seq_MESCs_Mouse | 2.45483063 |
| 15 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 2.45304794 |
| 16 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 2.44059203 |
| 17 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 2.42946441 |
| 18 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 2.39571812 |
| 19 | RARB_27405468_Chip-Seq_BRAIN_Mouse | 2.27220583 |
| 20 | SUZ12_27294783_Chip-Seq_ESCs_Mouse | 2.22485359 |
| 21 | AR_21572438_ChIP-Seq_LNCaP_Human | 2.22481621 |
| 22 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 2.17812657 |
| 23 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 2.16994471 |
| 24 | REST_18959480_ChIP-ChIP_MESCs_Mouse | 2.14477373 |
| 25 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 2.10639917 |
| 26 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 2.10593440 |
| 27 | RNF2_27304074_Chip-Seq_ESCs_Mouse | 2.10220357 |
| 28 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 2.05210993 |
| 29 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.87024142 |
| 30 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.86381221 |
| 31 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 1.80916444 |
| 32 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.80744592 |
| 33 | EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.76849137 |
| 34 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 1.74368939 |
| 35 | * CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.65079380 |
| 36 | SMAD4_21799915_ChIP-Seq_A2780_Human | 1.64308761 |
| 37 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.60375519 |
| 38 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.54778999 |
| 39 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 1.54677476 |
| 40 | VDR_22108803_ChIP-Seq_LS180_Human | 1.49330868 |
| 41 | MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 1.47820530 |
| 42 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.46152099 |
| 43 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.45566305 |
| 44 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.42098423 |
| 45 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.40301473 |
| 46 | * SOX2_21211035_ChIP-Seq_LN229_Gbm | 1.39057635 |
| 47 | P300_19829295_ChIP-Seq_ESCs_Human | 1.38236653 |
| 48 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 1.38158240 |
| 49 | * NR3C1_23031785_ChIP-Seq_PC12_Mouse | 1.37865443 |
| 50 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 1.35904558 |
| 51 | * KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse | 1.33706421 |
| 52 | RING1B_27294783_Chip-Seq_ESCs_Mouse | 1.32962417 |
| 53 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.29636972 |
| 54 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 1.28486924 |
| 55 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.26037548 |
| 56 | TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse | 1.25242883 |
| 57 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 1.24847088 |
| 58 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 1.24549774 |
| 59 | AR_25329375_ChIP-Seq_VCAP_Human | 1.24497225 |
| 60 | RCOR3_21632747_ChIP-Seq_MESCs_Mouse | 1.23611795 |
| 61 | RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 1.23479826 |
| 62 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.22413309 |
| 63 | STAT3_23295773_ChIP-Seq_U87_Human | 1.22325440 |
| 64 | ZNF217_24962896_ChIP-Seq_MCF-7_Human | 1.22280711 |
| 65 | AR_19668381_ChIP-Seq_PC3_Human | 1.22080209 |
| 66 | * OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.20557199 |
| 67 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 1.19795383 |
| 68 | STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse | 1.18506917 |
| 69 | NANOG_18555785_Chip-Seq_ESCs_Mouse | 1.18382452 |
| 70 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 1.18336104 |
| 71 | RING1B_27294783_Chip-Seq_NPCs_Mouse | 1.16854756 |
| 72 | * SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.15843873 |
| 73 | EWS_26573619_Chip-Seq_HEK293_Human | 1.15633666 |
| 74 | EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse | 1.15621528 |
| 75 | WT1_25993318_ChIP-Seq_PODOCYTE_Human | 1.15040419 |
| 76 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 1.13438061 |
| 77 | DNAJC2_21179169_ChIP-ChIP_NT2_Human | 1.12181707 |
| 78 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.11265416 |
| 79 | RNF2_27304074_Chip-Seq_NSC_Mouse | 1.10794120 |
| 80 | LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.10779339 |
| 81 | YAP1_20516196_ChIP-Seq_MESCs_Mouse | 1.10581854 |
| 82 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 1.10536568 |
| 83 | CBP_20019798_ChIP-Seq_JUKART_Human | 1.10536568 |
| 84 | * TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.10086986 |
| 85 | OLIG2_26023283_ChIP-Seq_AINV15_Mouse | 1.09692086 |
| 86 | ARNT_22903824_ChIP-Seq_MCF-7_Human | 1.09005675 |
| 87 | ZFP281_18757296_ChIP-ChIP_E14_Mouse | 1.08438762 |
| 88 | * TCF4_23295773_ChIP-Seq_U87_Human | 1.08430916 |
| 89 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.08174184 |
| 90 | * EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse | 1.06655057 |
| 91 | WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse | 1.06584281 |
| 92 | AHR_22903824_ChIP-Seq_MCF-7_Human | 1.04932370 |
| 93 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.04129463 |
| 94 | TCF3_18467660_ChIP-ChIP_MESCs_Mouse | 1.03929296 |
| 95 | P53_22127205_ChIP-Seq_FIBROBLAST_Human | 1.03177559 |
| 96 | KDM2B_26808549_Chip-Seq_K562_Human | 1.02834180 |
| 97 | TP53_16413492_ChIP-PET_HCT116_Human | 1.02638494 |
| 98 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.02420243 |
| 99 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.00664384 |
| 100 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 1.00430098 |
| 101 | MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse | 1.00311130 |
| 102 | * P53_22387025_ChIP-Seq_ESCs_Mouse | 1.00270712 |
| 103 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 0.98403473 |
| 104 | RUNX2_22187159_ChIP-Seq_PCA_Human | 0.97033633 |
| 105 | FUS_26573619_Chip-Seq_HEK293_Human | 0.97030880 |
| 106 | EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human | 0.96314324 |
| 107 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 0.95831155 |
| 108 | NR3C1_21868756_ChIP-Seq_MCF10A_Human | 0.94769739 |
| 109 | SMAD3_21741376_ChIP-Seq_ESCs_Human | 0.94651073 |
| 110 | SMAD4_21741376_ChIP-Seq_HESCs_Human | 0.94468704 |
| 111 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 0.94055866 |
| 112 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.94055866 |
| 113 | RCOR2_21632747_ChIP-Seq_MESCs_Mouse | 0.93731021 |
| 114 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 0.93526379 |
| 115 | CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.91985141 |
| 116 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 0.91217693 |
| 117 | * PRDM14_20953172_ChIP-Seq_ESCs_Human | 0.90947012 |
| 118 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 0.89064740 |
| 119 | TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.88852650 |
| 120 | TP53_18474530_ChIP-ChIP_U2OS_Human | 0.88850465 |
| 121 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 0.87412331 |
| 122 | BCAT_22108803_ChIP-Seq_LS180_Human | 0.87255816 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0004859_abnormal_synaptic_plasticity | 6.13860022 |
| 2 | MP0003880_abnormal_central_pattern | 4.90997625 |
| 3 | MP0003635_abnormal_synaptic_transmissio | 4.09696401 |
| 4 | MP0004270_analgesia | 3.81683532 |
| 5 | MP0002063_abnormal_learning/memory/cond | 3.25839959 |
| 6 | MP0009745_abnormal_behavioral_response | 3.21165276 |
| 7 | MP0005423_abnormal_somatic_nervous | 3.18562733 |
| 8 | MP0002064_seizures | 3.01326076 |
| 9 | MP0009046_muscle_twitch | 2.95115079 |
| 10 | MP0001968_abnormal_touch/_nociception | 2.89465302 |
| 11 | MP0002734_abnormal_mechanical_nocicepti | 2.80467044 |
| 12 | MP0002572_abnormal_emotion/affect_behav | 2.73176008 |
| 13 | MP0001486_abnormal_startle_reflex | 2.50378012 |
| 14 | MP0009780_abnormal_chondrocyte_physiolo | 2.34271115 |
| 15 | MP0002272_abnormal_nervous_system | 2.28540186 |
| 16 | MP0002822_catalepsy | 2.21573880 |
| 17 | MP0002733_abnormal_thermal_nociception | 2.21133725 |
| 18 | MP0000778_abnormal_nervous_system | 2.16931527 |
| 19 | MP0001501_abnormal_sleep_pattern | 2.11150762 |
| 20 | MP0001440_abnormal_grooming_behavior | 2.10584090 |
| 21 | MP0002735_abnormal_chemical_nociception | 2.09292777 |
| 22 | MP0006276_abnormal_autonomic_nervous | 2.09202850 |
| 23 | MP0006292_abnormal_olfactory_placode | 2.03447753 |
| 24 | MP0001970_abnormal_pain_threshold | 2.01923024 |
| 25 | MP0004924_abnormal_behavior | 1.99380779 |
| 26 | MP0005386_behavior/neurological_phenoty | 1.99380779 |
| 27 | MP0002736_abnormal_nociception_after | 1.96562463 |
| 28 | MP0002067_abnormal_sensory_capabilities | 1.93275525 |
| 29 | MP0002909_abnormal_adrenal_gland | 1.92032611 |
| 30 | MP0003122_maternal_imprinting | 1.89596620 |
| 31 | MP0002184_abnormal_innervation | 1.87615668 |
| 32 | MP0002557_abnormal_social/conspecific_i | 1.84754933 |
| 33 | MP0004811_abnormal_neuron_physiology | 1.83962160 |
| 34 | MP0001905_abnormal_dopamine_level | 1.69436441 |
| 35 | MP0001529_abnormal_vocalization | 1.67945523 |
| 36 | MP0003329_amyloid_beta_deposits | 1.67847962 |
| 37 | MP0008569_lethality_at_weaning | 1.65773086 |
| 38 | MP0000955_abnormal_spinal_cord | 1.62674297 |
| 39 | MP0003123_paternal_imprinting | 1.62608188 |
| 40 | MP0004858_abnormal_nervous_system | 1.61049186 |
| 41 | MP0001984_abnormal_olfaction | 1.60893836 |
| 42 | MP0005646_abnormal_pituitary_gland | 1.56448158 |
| 43 | MP0003890_abnormal_embryonic-extraembry | 1.53006513 |
| 44 | MP0003879_abnormal_hair_cell | 1.51557779 |
| 45 | MP0005645_abnormal_hypothalamus_physiol | 1.45409832 |
| 46 | MP0002653_abnormal_ependyma_morphology | 1.44925322 |
| 47 | MP0002066_abnormal_motor_capabilities/c | 1.41816421 |
| 48 | MP0002882_abnormal_neuron_morphology | 1.41064562 |
| 49 | MP0000751_myopathy | 1.38305123 |
| 50 | MP0003787_abnormal_imprinting | 1.35312342 |
| 51 | MP0001502_abnormal_circadian_rhythm | 1.34581775 |
| 52 | MP0004885_abnormal_endolymph | 1.34125273 |
| 53 | MP0000569_abnormal_digit_pigmentation | 1.33019478 |
| 54 | MP0008877_abnormal_DNA_methylation | 1.28445044 |
| 55 | MP0003633_abnormal_nervous_system | 1.25956653 |
| 56 | MP0004133_heterotaxia | 1.25419538 |
| 57 | MP0003119_abnormal_digestive_system | 1.19428324 |
| 58 | MP0002152_abnormal_brain_morphology | 1.17310448 |
| 59 | MP0005253_abnormal_eye_physiology | 1.16735423 |
| 60 | MP0006072_abnormal_retinal_apoptosis | 1.12823213 |
| 61 | MP0003631_nervous_system_phenotype | 1.12221404 |
| 62 | MP0001485_abnormal_pinna_reflex | 1.09441647 |
| 63 | MP0008872_abnormal_physiological_respon | 1.05197505 |
| 64 | MP0001188_hyperpigmentation | 1.04964989 |
| 65 | MP0000026_abnormal_inner_ear | 1.04437334 |
| 66 | MP0004142_abnormal_muscle_tone | 1.02781429 |
| 67 | MP0002751_abnormal_autonomic_nervous | 1.00219794 |
| 68 | MP0002837_dystrophic_cardiac_calcinosis | 0.96421711 |
| 69 | MP0002069_abnormal_eating/drinking_beha | 0.94969239 |
| 70 | MP0003938_abnormal_ear_development | 0.93701269 |
| 71 | MP0010386_abnormal_urinary_bladder | 0.93677234 |
| 72 | MP0000631_abnormal_neuroendocrine_gland | 0.92948081 |
| 73 | MP0003283_abnormal_digestive_organ | 0.91977691 |
| 74 | MP0008961_abnormal_basal_metabolism | 0.90765325 |
| 75 | MP0004085_abnormal_heartbeat | 0.89483726 |
| 76 | MP0005195_abnormal_posterior_eye | 0.89250444 |
| 77 | MP0005187_abnormal_penis_morphology | 0.88781246 |
| 78 | MP0001293_anophthalmia | 0.88742405 |
| 79 | MP0000049_abnormal_middle_ear | 0.88424658 |
| 80 | MP0008874_decreased_physiological_sensi | 0.88383631 |
| 81 | MP0003385_abnormal_body_wall | 0.87800550 |
| 82 | MP0005535_abnormal_body_temperature | 0.87273291 |
| 83 | MP0004145_abnormal_muscle_electrophysio | 0.85456095 |
| 84 | MP0003632_abnormal_nervous_system | 0.84716715 |
| 85 | MP0008789_abnormal_olfactory_epithelium | 0.83875620 |
| 86 | MP0002234_abnormal_pharynx_morphology | 0.83430976 |
| 87 | MP0004742_abnormal_vestibular_system | 0.83160221 |
| 88 | MP0005248_abnormal_Harderian_gland | 0.83154808 |
| 89 | MP0002229_neurodegeneration | 0.82182314 |
| 90 | MP0001177_atelectasis | 0.79563555 |
| 91 | MP0003942_abnormal_urinary_system | 0.78933998 |
| 92 | MP0002638_abnormal_pupillary_reflex | 0.78358913 |
| 93 | MP0003634_abnormal_glial_cell | 0.77438201 |
| 94 | MP0001963_abnormal_hearing_physiology | 0.75551860 |
| 95 | MP0000647_abnormal_sebaceous_gland | 0.75383276 |
| 96 | MP0003136_yellow_coat_color | 0.73541903 |
| 97 | MP0000534_abnormal_ureter_morphology | 0.73391638 |
| 98 | MP0002081_perinatal_lethality | 0.73346499 |
| 99 | MP0005499_abnormal_olfactory_system | 0.73079713 |
| 100 | MP0005394_taste/olfaction_phenotype | 0.73079713 |
| 101 | MP0005391_vision/eye_phenotype | 0.71861953 |
| 102 | MP0002233_abnormal_nose_morphology | 0.71710668 |
| 103 | MP0002752_abnormal_somatic_nervous | 0.71011121 |
| 104 | MP0001299_abnormal_eye_distance/ | 0.70374353 |
| 105 | MP0003121_genomic_imprinting | 0.70114769 |
| 106 | MP0000013_abnormal_adipose_tissue | 0.69427644 |
| 107 | MP0003937_abnormal_limbs/digits/tail_de | 0.68322484 |
| 108 | MP0005409_darkened_coat_color | 0.68197599 |
| 109 | MP0003861_abnormal_nervous_system | 0.66613959 |
| 110 | MP0003137_abnormal_impulse_conducting | 0.66359596 |
| 111 | MP0002090_abnormal_vision | 0.65860853 |
| 112 | MP0004215_abnormal_myocardial_fiber | 0.65544343 |
| 113 | MP0004484_altered_response_of | 0.65354342 |
| 114 | MP0003690_abnormal_glial_cell | 0.64835063 |
| 115 | MP0005551_abnormal_eye_electrophysiolog | 0.63320383 |
| 116 | MP0001664_abnormal_digestion | 0.62340012 |
| 117 | MP0000920_abnormal_myelination | 0.61638288 |
| 118 | MP0000604_amyloidosis | 0.61180958 |
| 119 | MP0001943_abnormal_respiration | 0.60558420 |
| 120 | MP0005623_abnormal_meninges_morphology | 0.60175073 |
| 121 | MP0004233_abnormal_muscle_weight | 0.59664616 |
| 122 | MP0001348_abnormal_lacrimal_gland | 0.58747201 |
| 123 | MP0010769_abnormal_survival | 0.58304560 |
| 124 | MP0010770_preweaning_lethality | 0.58097752 |
| 125 | MP0002082_postnatal_lethality | 0.58097752 |
| 126 | MP0004130_abnormal_muscle_cell | 0.55383094 |
| 127 | MP0010768_mortality/aging | 0.54293521 |
| 128 | MP0002102_abnormal_ear_morphology | 0.51761018 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Focal motor seizures (HP:0011153) | 6.45122998 |
| 2 | Myokymia (HP:0002411) | 5.96784021 |
| 3 | Focal seizures (HP:0007359) | 5.48171367 |
| 4 | Visual hallucinations (HP:0002367) | 5.12988858 |
| 5 | Epileptic encephalopathy (HP:0200134) | 4.55405129 |
| 6 | Limb dystonia (HP:0002451) | 4.31128036 |
| 7 | Atonic seizures (HP:0010819) | 4.05502359 |
| 8 | Progressive cerebellar ataxia (HP:0002073) | 4.01083561 |
| 9 | Broad-based gait (HP:0002136) | 3.86998434 |
| 10 | Papilledema (HP:0001085) | 3.86417249 |
| 11 | Supranuclear gaze palsy (HP:0000605) | 3.75672048 |
| 12 | Absence seizures (HP:0002121) | 3.74727293 |
| 13 | Mutism (HP:0002300) | 3.71019061 |
| 14 | Febrile seizures (HP:0002373) | 3.66412245 |
| 15 | Ankle clonus (HP:0011448) | 3.58037367 |
| 16 | Generalized tonic-clonic seizures (HP:0002069) | 3.57545623 |
| 17 | Hepatoblastoma (HP:0002884) | 3.51044066 |
| 18 | Poor eye contact (HP:0000817) | 3.39421633 |
| 19 | Dialeptic seizures (HP:0011146) | 3.37165731 |
| 20 | Hyperventilation (HP:0002883) | 3.36426595 |
| 21 | Abnormal eating behavior (HP:0100738) | 3.32515421 |
| 22 | Polyphagia (HP:0002591) | 3.23827666 |
| 23 | Action tremor (HP:0002345) | 3.19811131 |
| 24 | Urinary bladder sphincter dysfunction (HP:0002839) | 3.11352756 |
| 25 | Drooling (HP:0002307) | 3.05330075 |
| 26 | Excessive salivation (HP:0003781) | 3.05330075 |
| 27 | Impaired social interactions (HP:0000735) | 3.00786692 |
| 28 | Abnormal social behavior (HP:0012433) | 3.00786692 |
| 29 | Depression (HP:0000716) | 2.96275699 |
| 30 | Medial flaring of the eyebrow (HP:0010747) | 2.94985790 |
| 31 | Cerebral inclusion bodies (HP:0100314) | 2.92803336 |
| 32 | Genetic anticipation (HP:0003743) | 2.92773804 |
| 33 | Impaired vibration sensation in the lower limbs (HP:0002166) | 2.91288999 |
| 34 | Septo-optic dysplasia (HP:0100842) | 2.90142016 |
| 35 | Amblyopia (HP:0000646) | 2.87053634 |
| 36 | Torticollis (HP:0000473) | 2.82718272 |
| 37 | Abnormality of the corticospinal tract (HP:0002492) | 2.73513126 |
| 38 | Progressive inability to walk (HP:0002505) | 2.72669156 |
| 39 | Anxiety (HP:0000739) | 2.72465075 |
| 40 | Pheochromocytoma (HP:0002666) | 2.68462921 |
| 41 | Amyotrophic lateral sclerosis (HP:0007354) | 2.68203304 |
| 42 | Neurofibrillary tangles (HP:0002185) | 2.67902937 |
| 43 | Gaze-evoked nystagmus (HP:0000640) | 2.67167276 |
| 44 | Postural instability (HP:0002172) | 2.66467003 |
| 45 | Urinary urgency (HP:0000012) | 2.66241855 |
| 46 | Truncal ataxia (HP:0002078) | 2.64103901 |
| 47 | Pachygyria (HP:0001302) | 2.63622002 |
| 48 | Epileptiform EEG discharges (HP:0011182) | 2.63447369 |
| 49 | Genital tract atresia (HP:0001827) | 2.63088549 |
| 50 | Vaginal atresia (HP:0000148) | 2.61883040 |
| 51 | Insidious onset (HP:0003587) | 2.59538758 |
| 52 | Termporal pattern (HP:0011008) | 2.59538758 |
| 53 | Congenital primary aphakia (HP:0007707) | 2.58942099 |
| 54 | Spastic gait (HP:0002064) | 2.56557459 |
| 55 | EEG with generalized epileptiform discharges (HP:0011198) | 2.56398610 |
| 56 | Failure to thrive in infancy (HP:0001531) | 2.55264024 |
| 57 | Abnormality of the lower motor neuron (HP:0002366) | 2.54848473 |
| 58 | Dysmetria (HP:0001310) | 2.54018931 |
| 59 | Absent speech (HP:0001344) | 2.51354659 |
| 60 | Dysdiadochokinesis (HP:0002075) | 2.49296931 |
| 61 | Focal dystonia (HP:0004373) | 2.48708201 |
| 62 | Lissencephaly (HP:0001339) | 2.45266762 |
| 63 | Hypsarrhythmia (HP:0002521) | 2.45108539 |
| 64 | Inappropriate behavior (HP:0000719) | 2.44576137 |
| 65 | Nephrogenic diabetes insipidus (HP:0009806) | 2.41731527 |
| 66 | Bradykinesia (HP:0002067) | 2.39960249 |
| 67 | Inability to walk (HP:0002540) | 2.37718483 |
| 68 | Stereotypic behavior (HP:0000733) | 2.36963437 |
| 69 | Optic nerve hypoplasia (HP:0000609) | 2.36573435 |
| 70 | Hemiparesis (HP:0001269) | 2.35878915 |
| 71 | Agitation (HP:0000713) | 2.35251539 |
| 72 | Fetal akinesia sequence (HP:0001989) | 2.34927115 |
| 73 | Cortical dysplasia (HP:0002539) | 2.34167241 |
| 74 | Obstructive sleep apnea (HP:0002870) | 2.33724199 |
| 75 | Craniofacial dystonia (HP:0012179) | 2.33504719 |
| 76 | Akinesia (HP:0002304) | 2.32890620 |
| 77 | Hypoventilation (HP:0002791) | 2.31472355 |
| 78 | Morphological abnormality of the middle ear (HP:0008609) | 2.30949934 |
| 79 | Abnormality of binocular vision (HP:0011514) | 2.30734598 |
| 80 | Diplopia (HP:0000651) | 2.30734598 |
| 81 | Neoplasm of the adrenal cortex (HP:0100641) | 2.30575783 |
| 82 | Nephronophthisis (HP:0000090) | 2.27232097 |
| 83 | Lower limb muscle weakness (HP:0007340) | 2.26052781 |
| 84 | Neuroendocrine neoplasm (HP:0100634) | 2.25452484 |
| 85 | Sleep apnea (HP:0010535) | 2.23216711 |
| 86 | Pancreatic fibrosis (HP:0100732) | 2.23067400 |
| 87 | Growth hormone deficiency (HP:0000824) | 2.22593504 |
| 88 | Cutaneous finger syndactyly (HP:0010554) | 2.20134004 |
| 89 | Oligodactyly (hands) (HP:0001180) | 2.19430706 |
| 90 | Abnormality of the labia minora (HP:0012880) | 2.18556315 |
| 91 | Megalencephaly (HP:0001355) | 2.16158086 |
| 92 | Impaired smooth pursuit (HP:0007772) | 2.14380727 |
| 93 | Abnormal pancreas size (HP:0012094) | 2.11216144 |
| 94 | Morphological abnormality of the pyramidal tract (HP:0002062) | 2.11008346 |
| 95 | Hemiplegia (HP:0002301) | 2.10347065 |
| 96 | True hermaphroditism (HP:0010459) | 2.09965512 |
| 97 | Renal hypoplasia (HP:0000089) | 2.08714457 |
| 98 | High anterior hairline (HP:0009890) | 2.08172277 |
| 99 | Insomnia (HP:0100785) | 2.08095365 |
| 100 | Intention tremor (HP:0002080) | 2.06748823 |
| 101 | Retinal dysplasia (HP:0007973) | 2.06405646 |
| 102 | Abnormality of the renal medulla (HP:0100957) | 2.06117214 |
| 103 | Pancreatic cysts (HP:0001737) | 2.06094335 |
| 104 | Ventricular fibrillation (HP:0001663) | 2.05805393 |
| 105 | Abnormality of salivation (HP:0100755) | 2.04591011 |
| 106 | Poor coordination (HP:0002370) | 2.04534212 |
| 107 | Blue irides (HP:0000635) | 2.02940921 |
| 108 | Poor suck (HP:0002033) | 2.02225748 |
| 109 | Short 4th metacarpal (HP:0010044) | 2.01514812 |
| 110 | Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042) | 2.01514812 |
| 111 | Vitreoretinal degeneration (HP:0000655) | 1.98889915 |
| 112 | Generalized myoclonic seizures (HP:0002123) | 1.98186580 |
| 113 | Protruding tongue (HP:0010808) | 1.94868571 |
| 114 | Shawl scrotum (HP:0000049) | 1.94695006 |
| 115 | Lower limb amyotrophy (HP:0007210) | 1.93908103 |
| 116 | Aplasia/Hypoplasia of the optic nerve (HP:0008058) | 1.93021431 |
| 117 | Molar tooth sign on MRI (HP:0002419) | 1.92070614 |
| 118 | Abnormality of midbrain morphology (HP:0002418) | 1.92070614 |
| 119 | Clonus (HP:0002169) | 1.91888165 |
| 120 | Scanning speech (HP:0002168) | 1.90161166 |
| 121 | Abnormality of ocular smooth pursuit (HP:0000617) | 1.90014058 |
| 122 | Postaxial hand polydactyly (HP:0001162) | 1.89716181 |
| 123 | Impaired vibratory sensation (HP:0002495) | 1.87430489 |
| 124 | Exotropia (HP:0000577) | 1.86967286 |
| 125 | Hypoplasia of the brainstem (HP:0002365) | 1.86529849 |
| 126 | Aplasia/Hypoplasia of the brainstem (HP:0007362) | 1.86529849 |
| 127 | Type II lissencephaly (HP:0007260) | 1.86407860 |
| 128 | Aqueductal stenosis (HP:0002410) | 1.85830297 |
| 129 | Dysmetric saccades (HP:0000641) | 1.85211195 |
| 130 | Cutaneous syndactyly (HP:0012725) | 1.85050222 |
| 131 | Abnormality of the 4th metacarpal (HP:0010012) | 1.84858045 |
| 132 | Short foot (HP:0001773) | 1.83433613 |
| 133 | Gait imbalance (HP:0002141) | 1.82551184 |
| 134 | Narrow forehead (HP:0000341) | 1.82506634 |
| 135 | Intestinal atresia (HP:0011100) | 1.82063368 |
| 136 | Status epilepticus (HP:0002133) | 1.81935311 |
| 137 | Specific learning disability (HP:0001328) | 1.81412287 |
| 138 | Pointed chin (HP:0000307) | 1.81019945 |
| 139 | Congenital stationary night blindness (HP:0007642) | 1.79403841 |
| 140 | Incomplete penetrance (HP:0003829) | 1.79143910 |
| 141 | Open mouth (HP:0000194) | 1.78474789 |
| 142 | Hypoplasia of the corpus callosum (HP:0002079) | 1.77505932 |
| 143 | Generalized hypopigmentation of hair (HP:0011358) | 1.77398101 |
| 144 | Sporadic (HP:0003745) | 1.76395517 |
| 145 | Chronic hepatic failure (HP:0100626) | 1.75973952 |
| 146 | Micropenis (HP:0000054) | 1.70854093 |
| 147 | Abnormality of the ischium (HP:0003174) | 1.70645996 |
| 148 | Supernumerary spleens (HP:0009799) | 1.70287928 |
| 149 | Omphalocele (HP:0001539) | 1.68680825 |
| 150 | Neoplasm of the heart (HP:0100544) | 1.68224109 |
| 151 | Volvulus (HP:0002580) | 1.67911541 |
| 152 | Anophthalmia (HP:0000528) | 1.66687006 |
| 153 | Abnormality of the renal cortex (HP:0011035) | 1.64296378 |
| 154 | Absent septum pellucidum (HP:0001331) | 1.63478254 |
| 155 | Anencephaly (HP:0002323) | 1.63455387 |
| 156 | Esotropia (HP:0000565) | 1.63417224 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MARK1 | 5.02214279 |
| 2 | MAP3K9 | 3.87127811 |
| 3 | NTRK3 | 3.52328614 |
| 4 | MAP3K4 | 3.33008218 |
| 5 | EPHA4 | 3.01784320 |
| 6 | MAP2K7 | 2.83968124 |
| 7 | MINK1 | 2.58337547 |
| 8 | PAK6 | 2.43773208 |
| 9 | NTRK2 | 2.34910135 |
| 10 | DAPK2 | 2.31534299 |
| 11 | FRK | 2.29316256 |
| 12 | MAP3K12 | 2.18755240 |
| 13 | PINK1 | 2.15770219 |
| 14 | CASK | 2.09387184 |
| 15 | MAP2K4 | 2.07032308 |
| 16 | NTRK1 | 1.88562512 |
| 17 | CDK19 | 1.76108599 |
| 18 | LATS2 | 1.75140602 |
| 19 | KSR1 | 1.73954012 |
| 20 | KSR2 | 1.73847755 |
| 21 | MAPK13 | 1.72584128 |
| 22 | PNCK | 1.58914910 |
| 23 | PLK2 | 1.57567998 |
| 24 | CDK5 | 1.53079030 |
| 25 | PRKD3 | 1.52464882 |
| 26 | GRK5 | 1.51627189 |
| 27 | PHKG1 | 1.50989479 |
| 28 | PHKG2 | 1.50989479 |
| 29 | CAMKK1 | 1.49435182 |
| 30 | BMPR1B | 1.49295600 |
| 31 | UHMK1 | 1.42645825 |
| 32 | CSNK1G2 | 1.31331629 |
| 33 | DAPK1 | 1.30907981 |
| 34 | TNIK | 1.27453564 |
| 35 | MKNK2 | 1.20440467 |
| 36 | SIK2 | 1.15588996 |
| 37 | SCYL2 | 1.11011029 |
| 38 | PRKCG | 1.05518467 |
| 39 | STK38 | 1.04557340 |
| 40 | CDK18 | 1.04236389 |
| 41 | CDK15 | 1.02025386 |
| 42 | TAOK1 | 0.99894076 |
| 43 | TRIM28 | 0.99816751 |
| 44 | RET | 0.97912628 |
| 45 | CDK14 | 0.97578547 |
| 46 | TYRO3 | 0.96258979 |
| 47 | STK16 | 0.96157228 |
| 48 | CAMK2A | 0.94245891 |
| 49 | PAK3 | 0.92560913 |
| 50 | RIPK4 | 0.91429042 |
| 51 | STK11 | 0.90681007 |
| 52 | MAP3K2 | 0.89389196 |
| 53 | CDK11A | 0.88589088 |
| 54 | ERBB2 | 0.87963278 |
| 55 | PIK3CA | 0.86889532 |
| 56 | CAMK1G | 0.85783691 |
| 57 | OXSR1 | 0.84939973 |
| 58 | EPHA3 | 0.81043606 |
| 59 | PRPF4B | 0.80902458 |
| 60 | CAMKK2 | 0.80301835 |
| 61 | CAMK1 | 0.79951169 |
| 62 | YES1 | 0.79525459 |
| 63 | DYRK2 | 0.79422477 |
| 64 | FES | 0.77819323 |
| 65 | ADRBK2 | 0.77771062 |
| 66 | DYRK1A | 0.77696900 |
| 67 | CSNK1G3 | 0.77424905 |
| 68 | PRKCH | 0.76100122 |
| 69 | CAMK1D | 0.74633488 |
| 70 | ARAF | 0.72986453 |
| 71 | MARK2 | 0.72365183 |
| 72 | MAP4K2 | 0.68423205 |
| 73 | MKNK1 | 0.67882555 |
| 74 | MAP3K6 | 0.66529713 |
| 75 | SGK223 | 0.66483140 |
| 76 | SGK494 | 0.66483140 |
| 77 | GRK1 | 0.66439621 |
| 78 | CAMK2B | 0.66384477 |
| 79 | ERBB3 | 0.66232757 |
| 80 | ROCK2 | 0.66036808 |
| 81 | ALK | 0.65405739 |
| 82 | WNK4 | 0.63358221 |
| 83 | PTK2B | 0.62104207 |
| 84 | LATS1 | 0.62095741 |
| 85 | CCNB1 | 0.61417559 |
| 86 | ROCK1 | 0.59486349 |
| 87 | STK39 | 0.58851510 |
| 88 | CDC42BPA | 0.58485504 |
| 89 | SGK1 | 0.57772789 |
| 90 | INSRR | 0.57098133 |
| 91 | EPHB2 | 0.56405789 |
| 92 | PDK1 | 0.54652323 |
| 93 | LIMK1 | 0.54096401 |
| 94 | PRKCZ | 0.52968452 |
| 95 | LMTK2 | 0.51035358 |
| 96 | PDPK1 | 0.49670704 |
| 97 | WNK3 | 0.49360593 |
| 98 | CSNK1D | 0.48478924 |
| 99 | SGK2 | 0.48380683 |
| 100 | MAPK12 | 0.48241803 |
| 101 | MAP2K6 | 0.47947847 |
| 102 | ZAK | 0.47790311 |
| 103 | AKT3 | 0.47361221 |
| 104 | PRKCE | 0.46804618 |
| 105 | PRKG1 | 0.46355542 |
| 106 | CSNK1A1L | 0.45537304 |
| 107 | FYN | 0.45526576 |
| 108 | PKN1 | 0.45515741 |
| 109 | FGR | 0.44235371 |
| 110 | MAP3K13 | 0.43590845 |
| 111 | CSNK1E | 0.43464648 |
| 112 | DYRK1B | 0.43392342 |
| 113 | RAF1 | 0.43122571 |
| 114 | RPS6KA3 | 0.42192116 |
| 115 | RIPK1 | 0.41825441 |
| 116 | IRAK2 | 0.41471034 |
| 117 | CSNK1G1 | 0.40967784 |
| 118 | PRKAA1 | 0.40809995 |
| 119 | ADRBK1 | 0.40739049 |
| 120 | SGK3 | 0.40266017 |
| 121 | PRKACA | 0.40216319 |
| 122 | BCR | 0.38993358 |
| 123 | CSNK1A1 | 0.38203605 |
| 124 | RPS6KB1 | 0.36758057 |
| 125 | NEK6 | 0.35804268 |
| 126 | MAP2K1 | 0.34703989 |
| 127 | MAPK10 | 0.34317721 |
| 128 | MAPK8 | 0.34020911 |
| 129 | FGFR2 | 0.33704603 |
| 130 | RPS6KA2 | 0.33566411 |
| 131 | PRKDC | 0.33385483 |
| 132 | CAMK4 | 0.31312679 |
| 133 | MAP3K1 | 0.30999941 |
| 134 | CAMK2G | 0.30593764 |
| 135 | CAMK2D | 0.30495049 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Nicotine addiction_Homo sapiens_hsa05033 | 3.55753015 |
| 2 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 3.44475673 |
| 3 | GABAergic synapse_Homo sapiens_hsa04727 | 2.62354741 |
| 4 | Circadian entrainment_Homo sapiens_hsa04713 | 2.58957387 |
| 5 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 2.53384740 |
| 6 | Amphetamine addiction_Homo sapiens_hsa05031 | 2.49909408 |
| 7 | Olfactory transduction_Homo sapiens_hsa04740 | 2.46626501 |
| 8 | Long-term potentiation_Homo sapiens_hsa04720 | 2.44202276 |
| 9 | Morphine addiction_Homo sapiens_hsa05032 | 2.38600201 |
| 10 | Glutamatergic synapse_Homo sapiens_hsa04724 | 2.36753123 |
| 11 | Dopaminergic synapse_Homo sapiens_hsa04728 | 2.28740665 |
| 12 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 2.23297936 |
| 13 | Insulin secretion_Homo sapiens_hsa04911 | 2.05219256 |
| 14 | Cocaine addiction_Homo sapiens_hsa05030 | 2.00470348 |
| 15 | Salivary secretion_Homo sapiens_hsa04970 | 1.95891222 |
| 16 | Cholinergic synapse_Homo sapiens_hsa04725 | 1.95229226 |
| 17 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 1.90112263 |
| 18 | Gastric acid secretion_Homo sapiens_hsa04971 | 1.74907765 |
| 19 | Serotonergic synapse_Homo sapiens_hsa04726 | 1.69768723 |
| 20 | Renin secretion_Homo sapiens_hsa04924 | 1.69763876 |
| 21 | Taste transduction_Homo sapiens_hsa04742 | 1.64176006 |
| 22 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 1.62174056 |
| 23 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 1.61570853 |
| 24 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.61068844 |
| 25 | Long-term depression_Homo sapiens_hsa04730 | 1.59329268 |
| 26 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 1.51725887 |
| 27 | Axon guidance_Homo sapiens_hsa04360 | 1.47502404 |
| 28 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.45401426 |
| 29 | Gap junction_Homo sapiens_hsa04540 | 1.45314118 |
| 30 | GnRH signaling pathway_Homo sapiens_hsa04912 | 1.43289845 |
| 31 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 1.41535693 |
| 32 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.38867864 |
| 33 | Calcium signaling pathway_Homo sapiens_hsa04020 | 1.36736570 |
| 34 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 1.33017291 |
| 35 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 1.28589614 |
| 36 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 1.27742092 |
| 37 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 1.24209097 |
| 38 | cAMP signaling pathway_Homo sapiens_hsa04024 | 1.22329826 |
| 39 | ErbB signaling pathway_Homo sapiens_hsa04012 | 1.18006291 |
| 40 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 1.16929732 |
| 41 | Glioma_Homo sapiens_hsa05214 | 1.12731981 |
| 42 | Melanogenesis_Homo sapiens_hsa04916 | 1.08193054 |
| 43 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 1.06085060 |
| 44 | Steroid biosynthesis_Homo sapiens_hsa00100 | 1.02989689 |
| 45 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 1.00018959 |
| 46 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.98856487 |
| 47 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.98222678 |
| 48 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.96857655 |
| 49 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 0.95542585 |
| 50 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.94812744 |
| 51 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.94698734 |
| 52 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.90275776 |
| 53 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.89273510 |
| 54 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.89107743 |
| 55 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.83957313 |
| 56 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.82669769 |
| 57 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.78450541 |
| 58 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.78430899 |
| 59 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 0.74804506 |
| 60 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.72895780 |
| 61 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.72883324 |
| 62 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.72728789 |
| 63 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.71919062 |
| 64 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.71244004 |
| 65 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.70498389 |
| 66 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.70280004 |
| 67 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.70254177 |
| 68 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.68893262 |
| 69 | Endometrial cancer_Homo sapiens_hsa05213 | 0.68517266 |
| 70 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.67468702 |
| 71 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.66933063 |
| 72 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.66379206 |
| 73 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.65812500 |
| 74 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.65633497 |
| 75 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.64351702 |
| 76 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.64276843 |
| 77 | Alcoholism_Homo sapiens_hsa05034 | 0.62426037 |
| 78 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.61975158 |
| 79 | Colorectal cancer_Homo sapiens_hsa05210 | 0.58663809 |
| 80 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.57532108 |
| 81 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.56284332 |
| 82 | Tight junction_Homo sapiens_hsa04530 | 0.56118792 |
| 83 | Phototransduction_Homo sapiens_hsa04744 | 0.55691304 |
| 84 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.55457538 |
| 85 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.55208303 |
| 86 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.54929125 |
| 87 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.54785316 |
| 88 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.54533792 |
| 89 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.54075846 |
| 90 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.53808046 |
| 91 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.51764873 |
| 92 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.51608673 |
| 93 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.51305880 |
| 94 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.50288289 |
| 95 | Prion diseases_Homo sapiens_hsa05020 | 0.50262687 |
| 96 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.49724101 |
| 97 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.48509135 |
| 98 | Circadian rhythm_Homo sapiens_hsa04710 | 0.47113722 |
| 99 | Endocytosis_Homo sapiens_hsa04144 | 0.46728056 |
| 100 | ABC transporters_Homo sapiens_hsa02010 | 0.45827465 |
| 101 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.45797997 |
| 102 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 0.45711670 |
| 103 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.45285438 |
| 104 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.44699519 |
| 105 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.44689556 |
| 106 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.44670510 |
| 107 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.43559465 |
| 108 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.43441349 |
| 109 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.42742677 |
| 110 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.41847819 |
| 111 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.41224218 |
| 112 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.40472873 |
| 113 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.39605138 |
| 114 | Bile secretion_Homo sapiens_hsa04976 | 0.38594406 |
| 115 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.38120474 |
| 116 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.38021552 |
| 117 | Alzheimers disease_Homo sapiens_hsa05010 | 0.37196924 |
| 118 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.35042989 |
| 119 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.34229820 |
| 120 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 0.33463989 |
| 121 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.32865272 |
| 122 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.32261768 |
| 123 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.30579582 |

