LRRC56

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm-egg recognition (GO:0035036)9.63917298
2acrosome reaction (GO:0007340)9.31655810
3piRNA metabolic process (GO:0034587)9.25708695
4epithelial cilium movement (GO:0003351)9.10319709
5binding of sperm to zona pellucida (GO:0007339)9.01517113
6motile cilium assembly (GO:0044458)8.96429965
7acrosome assembly (GO:0001675)8.60467901
8cell-cell recognition (GO:0009988)8.56553249
9multicellular organism reproduction (GO:0032504)8.54529097
10spermatid development (GO:0007286)8.39520338
11cell wall macromolecule metabolic process (GO:0044036)8.28000882
12cell wall macromolecule catabolic process (GO:0016998)8.28000882
13cilium movement (GO:0003341)8.09489250
14epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)8.08629410
15plasma membrane fusion (GO:0045026)7.97861963
16male meiosis (GO:0007140)7.58363844
17synaptonemal complex organization (GO:0070193)7.48580605
18regulation of cilium movement (GO:0003352)7.34154681
19synaptonemal complex assembly (GO:0007130)7.24557106
20reproduction (GO:0000003)7.16166206
21single fertilization (GO:0007338)5.97816732
22DNA methylation involved in gamete generation (GO:0043046)5.78574854
23sperm capacitation (GO:0048240)5.75612520
24primary alcohol catabolic process (GO:0034310)5.75062964
25microtubule bundle formation (GO:0001578)5.74666222
26male meiosis I (GO:0007141)5.66087695
27spermatogenesis (GO:0007283)5.52482166
28male gamete generation (GO:0048232)5.50778525
29vitamin transmembrane transport (GO:0035461)5.45679995
30left/right axis specification (GO:0070986)5.40900593
31fertilization (GO:0009566)5.36800666
32negative regulation of inclusion body assembly (GO:0090084)5.22957338
33negative regulation of T cell differentiation in thymus (GO:0033085)5.20240305
34organic cation transport (GO:0015695)5.19591022
35lung epithelium development (GO:0060428)5.17612404
36chromosome organization involved in meiosis (GO:0070192)5.11990182
37tolerance induction (GO:0002507)5.08695839
38microtubule depolymerization (GO:0007019)5.04396465
39gamete generation (GO:0007276)5.04315196
40meiotic nuclear division (GO:0007126)4.98386317
41left/right pattern formation (GO:0060972)4.97570499
42establishment of apical/basal cell polarity (GO:0035089)4.96168608
43meiosis I (GO:0007127)4.91556157
44ethanol metabolic process (GO:0006067)4.89324423
45diterpenoid biosynthetic process (GO:0016102)4.85323392
46germ cell development (GO:0007281)4.83697710
47establishment of monopolar cell polarity (GO:0061162)4.68488514
48establishment or maintenance of monopolar cell polarity (GO:0061339)4.68488514
49cellular process involved in reproduction in multicellular organism (GO:0022412)4.68081370
50one-carbon compound transport (GO:0019755)4.64570577
51ventricular system development (GO:0021591)4.57840538
52meiotic cell cycle (GO:0051321)4.56651841
53response to xenobiotic stimulus (GO:0009410)4.56377820
54regulation of microtubule-based movement (GO:0060632)4.50580060
55regulation of inclusion body assembly (GO:0090083)4.27253350
56seminiferous tubule development (GO:0072520)4.24179377
57intraciliary transport (GO:0042073)4.18782638
58chromosome condensation (GO:0030261)4.07649160
59pyrimidine-containing compound transmembrane transport (GO:0072531)4.05821112
60DNA packaging (GO:0006323)3.96532357
61microtubule severing (GO:0051013)3.95741052
62multicellular organismal reproductive process (GO:0048609)3.94003727
63cellular component assembly involved in morphogenesis (GO:0010927)3.92841291
64cell recognition (GO:0008037)3.86369020
65axoneme assembly (GO:0035082)3.83202103
66calcium ion-dependent exocytosis (GO:0017156)3.75819450
67regulation of interleukin-5 production (GO:0032674)3.66745317
68cell projection assembly (GO:0030031)3.64808245
69retinoic acid metabolic process (GO:0042573)3.63873507
70protein localization to cilium (GO:0061512)3.60838033
71regulation of germinal center formation (GO:0002634)3.60696951
72regulation of interleukin-13 production (GO:0032656)3.59881574
73gene silencing by RNA (GO:0031047)3.59410778
74negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.58981882
75genitalia morphogenesis (GO:0035112)3.58278492
76glomerular epithelial cell development (GO:0072310)3.57432840
77protein polyglutamylation (GO:0018095)3.56975284
78nucleoside diphosphate phosphorylation (GO:0006165)3.56938443
79cytoplasmic microtubule organization (GO:0031122)3.42615152
80chaperone-mediated protein complex assembly (GO:0051131)3.40819328
81phosphatidylethanolamine biosynthetic process (GO:0006646)3.39915197
82spermatid nucleus differentiation (GO:0007289)3.39801469
83terpenoid biosynthetic process (GO:0016114)3.39107472
84ethanol oxidation (GO:0006069)3.35699559
85negative regulation of B cell mediated immunity (GO:0002713)3.35655687
86negative regulation of immunoglobulin mediated immune response (GO:0002890)3.35655687
87meiotic cell cycle process (GO:1903046)3.30191913
88protein refolding (GO:0042026)3.30114861
89amino-acid betaine transport (GO:0015838)3.29431691
90carnitine transport (GO:0015879)3.29431691
91nuclear pore complex assembly (GO:0051292)3.28985895
92phosphatidylcholine biosynthetic process (GO:0006656)3.26202738
93nucleosome disassembly (GO:0006337)3.25487560
94protein-DNA complex disassembly (GO:0032986)3.25487560
95monoubiquitinated protein deubiquitination (GO:0035520)3.25365825
96centriole assembly (GO:0098534)3.22372072
97glycerol ether metabolic process (GO:0006662)3.19980110
98RNA localization (GO:0006403)3.19339923
99carnitine transmembrane transport (GO:1902603)3.18419183
100phosphatidylethanolamine metabolic process (GO:0046337)3.17791166
101multicellular organismal development (GO:0007275)3.13075221
102exogenous drug catabolic process (GO:0042738)3.09895277
103positive regulation of tolerance induction (GO:0002645)3.09167414
104lactate metabolic process (GO:0006089)3.08863097
105negative regulation of organelle assembly (GO:1902116)3.07853912
106cilium organization (GO:0044782)3.05457714
107centriole replication (GO:0007099)3.04567635
108regulation of meiosis I (GO:0060631)3.04447032
109translesion synthesis (GO:0019985)3.02999431
110microtubule-based movement (GO:0007018)3.01654189
111regulation of cilium assembly (GO:1902017)3.00161208
112rRNA catabolic process (GO:0016075)3.00019644
113synapsis (GO:0007129)2.96528022
114ear development (GO:0043583)2.96509823
115phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.96427006
116gene silencing (GO:0016458)2.93824803
117cilium assembly (GO:0042384)2.92488554
118nucleus organization (GO:0006997)2.92483218
119ether metabolic process (GO:0018904)2.89206764
120cilium morphogenesis (GO:0060271)2.88669345
121cellular ketone body metabolic process (GO:0046950)2.88595004
122DNA replication-dependent nucleosome organization (GO:0034723)2.84464230
123DNA replication-dependent nucleosome assembly (GO:0006335)2.84464230
124regulation of spindle checkpoint (GO:0090231)2.84223294
125regulation of chromatin binding (GO:0035561)2.82710417
126peptidyl-glutamic acid modification (GO:0018200)2.80518776
127O-glycan processing (GO:0016266)2.79635493
128nuclear pore organization (GO:0006999)2.79345052
129microtubule polymerization or depolymerization (GO:0031109)2.76163893
130lateral ventricle development (GO:0021670)2.74815386
131histone exchange (GO:0043486)2.73883526
132regulation of autophagic vacuole assembly (GO:2000785)2.73710145
133DNA methylation (GO:0006306)2.70096521
134DNA alkylation (GO:0006305)2.70096521
135regulation of histone H3-K9 methylation (GO:0051570)2.69485772
136phenol-containing compound catabolic process (GO:0019336)2.68589801
137establishment of tissue polarity (GO:0007164)2.66706854
138establishment of planar polarity (GO:0001736)2.66706854
139cellular response to exogenous dsRNA (GO:0071360)2.66025666
140alditol metabolic process (GO:0019400)2.65390836
141histone H2A acetylation (GO:0043968)2.65216375
142fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.64708722
143retinol metabolic process (GO:0042572)2.62912513
144primary alcohol metabolic process (GO:0034308)2.62780623
145single strand break repair (GO:0000012)2.61419720
146glutathione biosynthetic process (GO:0006750)2.61328679
147calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.59270507
148negative regulation of humoral immune response (GO:0002921)2.57748368
149excretion (GO:0007588)2.55186163
150drug catabolic process (GO:0042737)2.54337098
151sensory perception of taste (GO:0050909)2.52534709
152L-fucose metabolic process (GO:0042354)2.52094612
153L-fucose catabolic process (GO:0042355)2.52094612
154fucose catabolic process (GO:0019317)2.52094612
155regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.51527133
156aldehyde catabolic process (GO:0046185)2.50822784
157response to pheromone (GO:0019236)2.50070523
158regulation of ruffle assembly (GO:1900027)2.49208046
159hydrogen peroxide biosynthetic process (GO:0050665)2.48234807
160photoreceptor cell maintenance (GO:0045494)2.46542428
161glutathione derivative metabolic process (GO:1901685)2.46165369
162glutathione derivative biosynthetic process (GO:1901687)2.46165369
163ketone body metabolic process (GO:1902224)2.45824160
164nonmotile primary cilium assembly (GO:0035058)2.44308852
165determination of left/right symmetry (GO:0007368)2.42205069
166regulation of vacuole organization (GO:0044088)2.38110964
167neurotransmitter catabolic process (GO:0042135)2.36654952
168smoothened signaling pathway (GO:0007224)2.36532289
169cilium or flagellum-dependent cell motility (GO:0001539)11.4596415
170sperm motility (GO:0030317)10.7499213
171fusion of sperm to egg plasma membrane (GO:0007342)10.6949570
172axonemal dynein complex assembly (GO:0070286)10.1059011

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.36596486
2BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.98493502
3DROSHA_22980978_ChIP-Seq_HELA_Human2.96289818
4FOXM1_23109430_ChIP-Seq_U2OS_Human2.93119017
5CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.85615964
6EZH2_22144423_ChIP-Seq_EOC_Human2.41537444
7STAT6_21828071_ChIP-Seq_BEAS2B_Human2.32648802
8TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.31836854
9SMC4_20622854_ChIP-Seq_HELA_Human2.24230713
10PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.10207686
11CTCF_27219007_Chip-Seq_Bcells_Human2.10100023
12MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse11.6592873
13* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.95663495
14LXR_22292898_ChIP-Seq_THP-1_Human1.93363048
15ELK4_26923725_Chip-Seq_MESODERM_Mouse1.91687798
16RUNX1_27514584_Chip-Seq_MCF-7_Human1.91430653
17TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.86234374
18* TP63_22573176_ChIP-Seq_HFKS_Human1.84069082
19TDRD3_21172665_ChIP-Seq_MCF-7_Human1.83879052
20GATA1_26923725_Chip-Seq_HPCs_Mouse1.78959794
21EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.78601440
22P300_27268052_Chip-Seq_Bcells_Human1.75950905
23FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.72157583
24* ERA_21632823_ChIP-Seq_H3396_Human1.71252942
25ESR2_21235772_ChIP-Seq_MCF-7_Human1.66354811
26FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.64589810
27FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.61892250
28ESR1_21235772_ChIP-Seq_MCF-7_Human1.61878423
29SOX2_22085726_ChIP-Seq_NPCs_Mouse1.58899304
30SA1_27219007_Chip-Seq_Bcells_Human1.56110826
31GATA3_21867929_ChIP-Seq_CD8_Mouse1.54221269
32EZH2_27294783_Chip-Seq_ESCs_Mouse1.52870675
33OCT4_20526341_ChIP-Seq_ESCs_Human1.52278973
34SA1_27219007_Chip-Seq_ERYTHROID_Human1.51790161
35* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.51052671
36RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.48015083
37E2F7_22180533_ChIP-Seq_HELA_Human1.48003584
38P63_26484246_Chip-Seq_KERATINOCYTES_Human1.45847552
39YY1_22570637_ChIP-Seq_MALME-3M_Human1.44757134
40ZNF274_21170338_ChIP-Seq_K562_Hela1.42297339
41FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.41199374
42RACK7_27058665_Chip-Seq_MCF-7_Human1.39988268
43CREB1_26743006_Chip-Seq_LNCaP_Human1.39650758
44TET1_21451524_ChIP-Seq_MESCs_Mouse1.39286299
45ESR1_20079471_ChIP-ChIP_T-47D_Human1.37653347
46MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.36896038
47WDR5_24793694_ChIP-Seq_LNCAP_Human1.35405285
48STAT1_17558387_ChIP-Seq_HELA_Human1.34008141
49P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.31775352
50EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.31520561
51KLF5_25053715_ChIP-Seq_YYC3_Human1.29541069
52E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.29402264
53ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.29303012
54VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.29156119
55TAF2_19829295_ChIP-Seq_ESCs_Human1.29062223
56* ELF1_20517297_ChIP-Seq_JURKAT_Human1.28735087
57SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.28114522
58THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.28015165
59ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.27947479
60EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.27881026
61OCT4_19829295_ChIP-Seq_ESCs_Human1.26823140
62EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.26802472
63RARA_24833708_ChIP-Seq_LIVER_Mouse1.26665297
64STAT1_20625510_ChIP-Seq_HELA_Human1.25839836
65RXRA_24833708_ChIP-Seq_LIVER_Mouse1.24128193
66DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.23530209
67MYC_19829295_ChIP-Seq_ESCs_Human1.23171459
68ELF1_17652178_ChIP-ChIP_JURKAT_Human1.22901792
69SUZ12_27294783_Chip-Seq_ESCs_Mouse1.21021177
70SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.20386904
71PHF8_20622854_ChIP-Seq_HELA_Human1.19700448
72AR_21909140_ChIP-Seq_LNCAP_Human1.18554835
73SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.17269828
74* BCOR_27268052_Chip-Seq_Bcells_Human1.16576972
75KAP1_22055183_ChIP-Seq_ESCs_Mouse1.15787651
76SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.15773092
77P53_21459846_ChIP-Seq_SAOS-2_Human1.15733510
78RAD21_21589869_ChIP-Seq_MESCs_Mouse1.14562683
79BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human1.14391310
80TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.13467842
81SOX2_21211035_ChIP-Seq_LN229_Human1.11959727
82EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.11815465
83IKZF1_21737484_ChIP-ChIP_HCT116_Human1.10922482
84TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.09951170
85ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.08886638
86GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.08580986
87SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.08400209
88CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.07659229
89CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.07541737
90ERG_20517297_ChIP-Seq_VCAP_Human1.07360602
91CEBPB_22108803_ChIP-Seq_LS180_Human1.06800560
92CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.06703145
93ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.06659167
94GATA3_21878914_ChIP-Seq_MCF-7_Human1.06549936
95FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.06183818
96SPI1_26923725_Chip-Seq_HPCs_Mouse1.06165636
97CTCF_20526341_ChIP-Seq_ESCs_Human1.05964611
98MYCN_18555785_ChIP-Seq_MESCs_Mouse1.05375222
99E2F1_20622854_ChIP-Seq_HELA_Human1.04440114
100HOXB7_26014856_ChIP-Seq_BT474_Human1.04400720
101GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02947703
102* FOXP1_21924763_ChIP-Seq_HESCs_Human1.02202136
103RUNX1_26923725_Chip-Seq_HPCs_Mouse1.01218485
104* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.00991872
105CTCF_26484167_Chip-Seq_Bcells_Mouse1.00277625
106SMRT_27268052_Chip-Seq_Bcells_Human1.00271068
107BCL6_27268052_Chip-Seq_Bcells_Human0.99898701
108RARB_24833708_ChIP-Seq_LIVER_Mouse0.99708273
109IRF8_22096565_ChIP-ChIP_GC-B_Human0.99273969
110SOX11_22085726_ChIP-Seq_ESNs_Mouse0.98992807
111RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.98574161
112PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98376754
113LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.97982021
114RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.97412417
115AHR_22903824_ChIP-Seq_MCF-7_Human0.96718683
116FOXA1_25329375_ChIP-Seq_VCAP_Human0.96577740
117FOXA1_27270436_Chip-Seq_PROSTATE_Human0.96577740
118BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.96147348
119PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.95845856
120NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.95359116
121SPI1_20517297_ChIP-Seq_HL60_Human0.94293772
122TP53_22127205_ChIP-Seq_IMR90_Human0.94138516
123LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.93485778
124CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.93447283
125VDR_22108803_ChIP-Seq_LS180_Human0.93414366
126NFIB_24661679_ChIP-Seq_LUNG_Mouse0.93003256
127PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.92936018
128CTCF_18555785_ChIP-Seq_MESCs_Mouse0.92690738
129DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.92681412
130NANOG_20526341_ChIP-Seq_ESCs_Human0.92490920
131CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.92424490
132FLI1_21867929_ChIP-Seq_CD8_Mouse0.92416602
133SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.91974775
134MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.91822016
135TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.91144362
136STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.90662481
137KLF4_19829295_ChIP-Seq_ESCs_Human0.90590713
138E2F4_17652178_ChIP-ChIP_JURKAT_Human0.89745755
139SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.89564534
140SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.89305062
141RBPJ_22232070_ChIP-Seq_NCS_Mouse0.88839233
142CTCF_27219007_Chip-Seq_ERYTHROID_Human0.88525254
143SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.88328748
144GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.88274272
145* TET1_21490601_ChIP-Seq_MESCs_Mouse0.87782933
146KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.87723862
147AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.87654259
148SRY_22984422_ChIP-ChIP_TESTIS_Rat0.87210425
149ETS1_21867929_ChIP-Seq_TH2_Mouse0.86168928
150HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.86133465
151MYC_18358816_ChIP-ChIP_MESCs_Mouse0.85887519
152MYC_27129775_Chip-Seq_CORNEA_Mouse0.85738039
153MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.85504466
154ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.84939932
155RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.84490363
156JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.84108479
157KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.83994780
158RAC3_21632823_ChIP-Seq_H3396_Human0.83254263
159KLF4_18555785_ChIP-Seq_MESCs_Mouse0.82868822
160P68_20966046_ChIP-Seq_HELA_Human0.82561047
161NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.81268754
162GF1_26923725_Chip-Seq_HPCs_Mouse0.80082109
163RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.79931320
164JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.79863278

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.21650525
2MP0001929_abnormal_gametogenesis4.95948724
3MP0008877_abnormal_DNA_methylation4.60542347
4MP0002210_abnormal_sex_determination3.42046901
5MP0002653_abnormal_ependyma_morphology3.28985025
6MP0009780_abnormal_chondrocyte_physiolo3.16337556
7MP0001145_abnormal_male_reproductive2.98429258
8MP0002161_abnormal_fertility/fecundity2.91468584
9MP0002277_abnormal_respiratory_mucosa2.85042161
10MP0000653_abnormal_sex_gland2.56864806
11MP0000566_synostosis2.53756783
12MP0000383_abnormal_hair_follicle2.13893875
13MP0002876_abnormal_thyroid_physiology2.03478870
14MP0002160_abnormal_reproductive_system2.03042532
15MP0002249_abnormal_larynx_morphology2.02993139
16MP0002822_catalepsy2.00551481
17MP0005410_abnormal_fertilization12.6376032
18MP0008058_abnormal_DNA_repair1.95144153
19MP0010094_abnormal_chromosome_stability1.92064925
20MP0003283_abnormal_digestive_organ1.89694500
21MP0001984_abnormal_olfaction1.86445512
22MP0008789_abnormal_olfactory_epithelium1.83037915
23MP0005670_abnormal_white_adipose1.81926699
24MP0005645_abnormal_hypothalamus_physiol1.81729206
25MP0002139_abnormal_hepatobiliary_system1.80445336
26MP0005360_urolithiasis1.68707846
27MP0001873_stomach_inflammation1.65799122
28MP0002168_other_aberrant_phenotype1.60253566
29MP0003111_abnormal_nucleus_morphology1.60010428
30MP0004133_heterotaxia1.56387520
31MP0005310_abnormal_salivary_gland1.48285525
32MP0001502_abnormal_circadian_rhythm1.46916272
33MP0010678_abnormal_skin_adnexa1.46642324
34MP0005365_abnormal_bile_salt1.46416908
35MP0003787_abnormal_imprinting1.46096743
36MP0003045_fibrosis1.43941885
37MP0008872_abnormal_physiological_respon1.37271052
38MP0002735_abnormal_chemical_nociception1.35467167
39MP0002282_abnormal_trachea_morphology1.33668634
40MP0001485_abnormal_pinna_reflex1.32761722
41MP0003866_abnormal_defecation1.31530073
42MP0009379_abnormal_foot_pigmentation1.30749585
43MP0001968_abnormal_touch/_nociception1.30463170
44MP0001348_abnormal_lacrimal_gland1.29579375
45MP0003115_abnormal_respiratory_system1.28354367
46MP0004885_abnormal_endolymph1.28191212
47MP0003136_yellow_coat_color1.25907144
48MP0005551_abnormal_eye_electrophysiolog1.24867656
49MP0002909_abnormal_adrenal_gland1.24577748
50MP0010155_abnormal_intestine_physiology1.23848656
51MP0003656_abnormal_erythrocyte_physiolo1.20112746
52MP0004233_abnormal_muscle_weight1.19068170
53MP0005636_abnormal_mineral_homeostasis1.16548869
54MP0003077_abnormal_cell_cycle1.14384708
55MP0008995_early_reproductive_senescence1.12997881
56MP0004043_abnormal_pH_regulation1.12122023
57MP0000026_abnormal_inner_ear1.11465777
58MP0008057_abnormal_DNA_replication1.10672568
59MP0005389_reproductive_system_phenotype1.09409715
60MP0002928_abnormal_bile_duct1.08285780
61MP0005083_abnormal_biliary_tract1.05165184
62MP0005499_abnormal_olfactory_system1.03684138
63MP0005394_taste/olfaction_phenotype1.03684138
64MP0004147_increased_porphyrin_level1.03589321
65MP0005220_abnormal_exocrine_pancreas1.03497107
66MP0005387_immune_system_phenotype1.00947031
67MP0001790_abnormal_immune_system1.00947031
68MP0002234_abnormal_pharynx_morphology1.00501810
69MP0001188_hyperpigmentation1.00369641
70MP0003693_abnormal_embryo_hatching1.00099099
71MP0003806_abnormal_nucleotide_metabolis0.99750258
72MP0001765_abnormal_ion_homeostasis0.99732477
73MP0005395_other_phenotype0.99027097
74MP0002638_abnormal_pupillary_reflex0.97484276
75MP0001986_abnormal_taste_sensitivity0.96971182
76MP0001346_abnormal_lacrimal_gland0.94895296
77MP0003011_delayed_dark_adaptation0.94890000
78MP0008875_abnormal_xenobiotic_pharmacok0.94259746
79MP0002098_abnormal_vibrissa_morphology0.93862958
80MP0009053_abnormal_anal_canal0.92523375
81MP0003195_calcinosis0.91288297
82MP0002136_abnormal_kidney_physiology0.91153835
83MP0001730_embryonic_growth_arrest0.90357902
84MP0005623_abnormal_meninges_morphology0.90177828
85MP0004742_abnormal_vestibular_system0.87627974
86MP0002734_abnormal_mechanical_nocicepti0.87059638
87MP0006036_abnormal_mitochondrial_physio0.87032676
88MP0002229_neurodegeneration0.86570709
89MP0005646_abnormal_pituitary_gland0.86562570
90MP0000358_abnormal_cell_content/0.85898205
91MP0001293_anophthalmia0.85012463
92MP0003890_abnormal_embryonic-extraembry0.84842150
93MP0009046_muscle_twitch0.83762916
94MP0000427_abnormal_hair_cycle0.83610717
95MP0000685_abnormal_immune_system0.83384986
96MP0003119_abnormal_digestive_system0.82542756
97MP0001663_abnormal_digestive_system0.81555019
98MP0001970_abnormal_pain_threshold0.80560859
99MP0001944_abnormal_pancreas_morphology0.79201017
100MP0001764_abnormal_homeostasis0.79077967
101MP0004381_abnormal_hair_follicle0.78309506
102MP0005377_hearing/vestibular/ear_phenot0.78245801
103MP0003878_abnormal_ear_physiology0.78245801
104MP0008007_abnormal_cellular_replicative0.77198209
105MP0000681_abnormal_thyroid_gland0.75512666
106MP0008961_abnormal_basal_metabolism0.75414127
107MP0009745_abnormal_behavioral_response0.74310244
108MP0003252_abnormal_bile_duct0.74025834
109MP0000462_abnormal_digestive_system0.74018256
110MP0010329_abnormal_lipoprotein_level0.73524052
111MP0002693_abnormal_pancreas_physiology0.72618933
112MP0010234_abnormal_vibrissa_follicle0.72547120
113MP0004957_abnormal_blastocyst_morpholog0.72433990
114MP0003879_abnormal_hair_cell0.72229052
115MP0000613_abnormal_salivary_gland0.71064382
116MP0001963_abnormal_hearing_physiology0.69791645
117MP0004808_abnormal_hematopoietic_stem0.69531930
118MP0003942_abnormal_urinary_system0.69285600
119MP0005085_abnormal_gallbladder_physiolo0.67936519
120MP0002084_abnormal_developmental_patter0.67834536
121MP0002272_abnormal_nervous_system0.67802539
122MP0002557_abnormal_social/conspecific_i0.65791585
123MP0001849_ear_inflammation0.65159995
124MP0001672_abnormal_embryogenesis/_devel0.64925134
125MP0005380_embryogenesis_phenotype0.64925134
126MP0000467_abnormal_esophagus_morphology0.64284642
127MP0003646_muscle_fatigue0.63988803
128MP0005075_abnormal_melanosome_morpholog0.63431345
129MP0002736_abnormal_nociception_after0.63288664
130MP0009672_abnormal_birth_weight0.63279906
131MP0002254_reproductive_system_inflammat0.63250308
132MP0003638_abnormal_response/metabolism_0.63008866
133MP0005397_hematopoietic_system_phenotyp0.62082259
134MP0001545_abnormal_hematopoietic_system0.62082259
135MP0003786_premature_aging0.61611828
136MP0001905_abnormal_dopamine_level0.60910375
137MP0001800_abnormal_humoral_immune0.60674996
138MP0008932_abnormal_embryonic_tissue0.60081221
139MP0009643_abnormal_urine_homeostasis0.59889951
140MP0006276_abnormal_autonomic_nervous0.59091756
141MP0000313_abnormal_cell_death0.58706549
142MP0003699_abnormal_female_reproductive0.58344470
143MP0002085_abnormal_embryonic_tissue0.57952653
144MP0000534_abnormal_ureter_morphology0.57919272
145MP0004264_abnormal_extraembryonic_tissu0.57564786
146MP0001664_abnormal_digestion0.57275623
147MP0005253_abnormal_eye_physiology0.56574569
148MP0003938_abnormal_ear_development0.55836166
149MP0004019_abnormal_vitamin_homeostasis0.53679544
150MP0002080_prenatal_lethality0.53157782
151MP0001119_abnormal_female_reproductive0.52989786
152MP0001697_abnormal_embryo_size0.52499991
153MP0003861_abnormal_nervous_system0.52455773
154MP0000609_abnormal_liver_physiology0.52395354
155MP0010307_abnormal_tumor_latency0.52249085
156MP0009278_abnormal_bone_marrow0.51935524
157MP0005647_abnormal_sex_gland0.50138635
158MP0002092_abnormal_eye_morphology0.47127651
159MP0000350_abnormal_cell_proliferation0.46812505
160MP0000678_abnormal_parathyroid_gland0.46496642
161MP0000537_abnormal_urethra_morphology0.46150969
162MP0004197_abnormal_fetal_growth/weight/0.45359898
163MP0003984_embryonic_growth_retardation0.45111474
164MP0006072_abnormal_retinal_apoptosis0.45019291
165MP0009703_decreased_birth_body0.43580762
166MP0002132_abnormal_respiratory_system0.43048401
167MP0002697_abnormal_eye_size0.42819523
168MP0001666_abnormal_nutrient_absorption0.42330914
169MP0002118_abnormal_lipid_homeostasis0.41871683

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)8.86466651
2Abnormal respiratory epithelium morphology (HP:0012253)8.33644116
3Abnormal respiratory motile cilium morphology (HP:0005938)8.33644116
4Rhinitis (HP:0012384)7.66645190
5Chronic bronchitis (HP:0004469)7.61369721
6Abnormal ciliary motility (HP:0012262)7.18531092
7Nasal polyposis (HP:0100582)6.16592572
8Infertility (HP:0000789)5.96109067
9Abnormality of the nasal mucosa (HP:0000433)5.26824675
10Bronchiectasis (HP:0002110)4.71049118
11Bronchitis (HP:0012387)4.58683252
12Nephronophthisis (HP:0000090)4.34894374
13Tubulointerstitial nephritis (HP:0001970)3.71074391
14Abnormality of the renal medulla (HP:0100957)3.49408331
15Atelectasis (HP:0100750)3.17585421
16Recurrent otitis media (HP:0000403)3.14581554
17Male infertility (HP:0003251)3.08481685
18Impulsivity (HP:0100710)3.01783916
19Recurrent sinusitis (HP:0011108)2.97836914
20Abnormal spermatogenesis (HP:0008669)2.85207289
21Chronic hepatic failure (HP:0100626)2.83236113
22Hyperactive renin-angiotensin system (HP:0000841)2.73936507
23Tubulointerstitial abnormality (HP:0001969)2.70006705
24Chronic otitis media (HP:0000389)2.66332760
25Aplasia/Hypoplasia of the spleen (HP:0010451)2.61915243
26Abnormality of midbrain morphology (HP:0002418)2.61625933
27Molar tooth sign on MRI (HP:0002419)2.61625933
28Gonadotropin excess (HP:0000837)2.61530897
29Asplenia (HP:0001746)2.57005903
30Recurrent bronchitis (HP:0002837)2.56892273
31Tubular atrophy (HP:0000092)2.40892915
32Postaxial foot polydactyly (HP:0001830)2.40047284
33Abnormal rod and cone electroretinograms (HP:0008323)2.39471252
34Medial flaring of the eyebrow (HP:0010747)2.38309423
35Male pseudohermaphroditism (HP:0000037)2.34326389
36Absent rod-and cone-mediated responses on ERG (HP:0007688)2.28791946
37Sclerocornea (HP:0000647)2.28567237
38Cystic liver disease (HP:0006706)2.28271547
39Abnormality of the lower motor neuron (HP:0002366)2.27182416
40Decreased circulating renin level (HP:0003351)2.27143103
41Fibular hypoplasia (HP:0003038)2.22165245
42Broad distal phalanx of finger (HP:0009836)2.19638691
43Hypoplasia of the capital femoral epiphysis (HP:0003090)2.17822372
44Heterotopia (HP:0002282)2.16612564
45Azoospermia (HP:0000027)2.08613270
46Renal salt wasting (HP:0000127)2.04003755
47Furrowed tongue (HP:0000221)2.03473353
48Congenital hepatic fibrosis (HP:0002612)2.01642804
49Respiratory insufficiency due to defective ciliary clearance (HP:0200073)11.9087353
50Absent/shortened dynein arms (HP:0200106)10.9782543
51Dynein arm defect of respiratory motile cilia (HP:0012255)10.9782543
52Abnormal biliary tract physiology (HP:0012439)1.98480595
53Bile duct proliferation (HP:0001408)1.98480595
54Chronic sinusitis (HP:0011109)1.96053202
55Renal dysplasia (HP:0000110)1.95104619
56Abnormal gallbladder physiology (HP:0012438)1.93027989
57Cholecystitis (HP:0001082)1.93027989
58Tubulointerstitial fibrosis (HP:0005576)1.90941626
59Stridor (HP:0010307)1.89198964
60Abnormality of the renal cortex (HP:0011035)1.86469461
61Supernumerary spleens (HP:0009799)1.86323924
62Pancreatic fibrosis (HP:0100732)1.83177455
63Oculomotor apraxia (HP:0000657)1.82196079
64Short ribs (HP:0000773)1.80904400
65Stage 5 chronic kidney disease (HP:0003774)1.79749070
66Abnormality of renin-angiotensin system (HP:0000847)1.79039497
67Abnormal drinking behavior (HP:0030082)1.75967776
68Polydipsia (HP:0001959)1.75967776
69True hermaphroditism (HP:0010459)1.75899257
70Hyperkalemia (HP:0002153)1.74481940
71Spastic tetraparesis (HP:0001285)1.72729258
72Pancreatic cysts (HP:0001737)1.72456039
73Type II lissencephaly (HP:0007260)1.72390275
7411 pairs of ribs (HP:0000878)1.70239121
75Abnormality of renal excretion (HP:0011036)1.70132079
76Postaxial hand polydactyly (HP:0001162)1.69836108
77Renovascular hypertension (HP:0100817)1.67280804
78Occipital encephalocele (HP:0002085)1.64816481
79Facial cleft (HP:0002006)1.63998652
80Absent epiphyses (HP:0010577)1.62550968
81Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.62550968
82Degeneration of anterior horn cells (HP:0002398)1.59659348
83Abnormality of the anterior horn cell (HP:0006802)1.59659348
84Aplasia/Hypoplasia of the tongue (HP:0010295)1.59291638
85Insomnia (HP:0100785)1.55240002
86Impaired proprioception (HP:0010831)1.55025105
87Hyperinsulinemic hypoglycemia (HP:0000825)1.54833470
88Amelogenesis imperfecta (HP:0000705)1.52829879
89Obstructive sleep apnea (HP:0002870)1.52490809
90Poikilocytosis (HP:0004447)1.50454857
91Abnormal urine output (HP:0012590)1.50453337
92Nephropathy (HP:0000112)1.49698118
93Hyperaldosteronism (HP:0000859)1.49496939
94Congenital stationary night blindness (HP:0007642)1.46698853
95Median cleft lip (HP:0000161)1.46473590
96Bell-shaped thorax (HP:0001591)1.46174728
97Acanthocytosis (HP:0001927)1.45171421
98Elfin facies (HP:0004428)1.44245510
99Ketosis (HP:0001946)1.42909784
100Abnormality of chloride homeostasis (HP:0011422)1.40508518
101Bifid tongue (HP:0010297)1.40485458
102Polyuria (HP:0000103)1.40263225
103Hand muscle atrophy (HP:0009130)1.38680293
104Reticulocytosis (HP:0001923)1.37896841
105Hyperacusis (HP:0010780)1.37872499
106Hemorrhage of the eye (HP:0011885)1.37837740
107Abnormality of the heme biosynthetic pathway (HP:0010472)1.36982660
108Amyotrophic lateral sclerosis (HP:0007354)1.36547566
109Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.35342298
110Sloping forehead (HP:0000340)1.35215931
111Bony spicule pigmentary retinopathy (HP:0007737)1.34772286
112Short thorax (HP:0010306)1.34029444
113Short femoral neck (HP:0100864)1.32034586
114Optic nerve coloboma (HP:0000588)1.31820017
115Congenital primary aphakia (HP:0007707)1.30736151
116Selective tooth agenesis (HP:0001592)1.30662240
117Anencephaly (HP:0002323)1.30268558
118Gait imbalance (HP:0002141)1.30250592
119Aplasia/Hypoplasia of the lens (HP:0008063)1.27791964
120Retinal atrophy (HP:0001105)1.26003923
121Retinitis pigmentosa (HP:0000510)1.25538712
122Hypokalemic alkalosis (HP:0001949)1.23709104
123Aplasia/Hypoplasia of the fibula (HP:0006492)1.23476298
124Preaxial hand polydactyly (HP:0001177)1.23005324
125Decreased central vision (HP:0007663)1.22374976
126Renal duplication (HP:0000075)1.22373667
127Nephrogenic diabetes insipidus (HP:0009806)1.21593475
128Polycystic kidney dysplasia (HP:0000113)1.21473212
129Gout (HP:0001997)1.20898813
130Abnormality of macular pigmentation (HP:0008002)1.19670282
131Attenuation of retinal blood vessels (HP:0007843)1.17904921
132Cone-rod dystrophy (HP:0000548)1.17378999
133Sleep apnea (HP:0010535)1.15667805
134Large for gestational age (HP:0001520)1.15011281
135Abnormality of the distal phalanges of the toes (HP:0010182)1.14715233
136Hyponatremia (HP:0002902)1.13192123
137Hyperthyroidism (HP:0000836)1.12289590
138Elevated erythrocyte sedimentation rate (HP:0003565)1.11636121
139Diaphragmatic weakness (HP:0009113)1.11614393
140Multicystic kidney dysplasia (HP:0000003)1.11613073
141Disproportionate short-trunk short stature (HP:0003521)1.11436054
142Severe visual impairment (HP:0001141)1.11113330
143Aplasia/Hypoplasia of the sacrum (HP:0008517)1.08860293
144Self-mutilation (HP:0000742)1.08560624
145Aplasia/hypoplasia of the femur (HP:0005613)1.06058760

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK46.97137783
2PDK36.97137783
3TESK15.26736294
4PRKD34.22199926
5PDK24.18234647
6EPHA24.14535109
7ICK3.86867120
8MST42.97544096
9NEK22.78794581
10WNK42.53353759
11NME12.51537808
12TLK12.48330751
13SMG12.36961740
14PASK2.04408791
15MAPK152.03540538
16BRSK21.95959395
17DYRK1B1.90189111
18SIK21.85119800
19PNCK1.81406486
20CDC71.77455737
21DYRK31.69755970
22EEF2K1.65877361
23BRSK11.65608075
24FRK1.51966261
25TNK21.50909568
26PTK2B1.50444635
27STK391.49218067
28GRK11.48392756
29PRKCI1.44528193
30MAP2K21.43907417
31WEE11.39842862
32MAP2K61.38792018
33MAP3K101.36085616
34GRK61.31428771
35ADRBK21.31281651
36MST1R1.20833222
37SIK31.15531803
38RIPK41.15490094
39STK381.14596032
40CDK121.14482452
41CHEK21.11474540
42TTK1.11021526
43CCNB11.10071351
44EPHB11.06301140
45MAP3K71.02257380
46MAP3K21.02007143
47TXK0.98479621
48TBK10.97888204
49EPHA30.97010316
50ATR0.95162775
51STK30.93157692
52ERBB20.92618857
53CAMKK10.92484489
54PHKG20.89062918
55PHKG10.89062918
56TRPM70.85464998
57IKBKB0.84741349
58ITK0.83922434
59NEK10.81882155
60INSRR0.77946294
61ERN10.76608236
62OXSR10.76558853
63MARK30.75381534
64LMTK20.73345490
65BCKDK0.73076934
66BTK0.72643573
67CSK0.72247765
68BUB10.71097081
69MATK0.70617433
70PRKAA20.68249017
71PRKCQ0.67502026
72PRKD20.67429668
73TEC0.66626352
74CHEK10.65886628
75MUSK0.64698475
76MTOR0.63164883
77PTK60.62889445
78WNK10.62657577
79AURKA0.62429403
80STK100.61493655
81CDK70.60257619
82PLK10.59916372
83MAP4K10.58850884
84STK40.58214604
85CAMK1G0.57260328
86MAPKAPK30.56905077
87MARK20.55522970
88TESK20.55167867
89PDK10.54403815
90HIPK20.53897865
91MAP3K130.51753380
92RPS6KB20.51739879
93STK240.51143467
94RPS6KA60.51041248
95MAP4K20.50536897
96EIF2AK10.48741638
97IKBKE0.47520268
98TRIB30.47407570
99TYRO30.45695524
100ATM0.42256807
101IRAK10.42051762
102MAPK130.40575929
103MAP3K10.40372894
104MAPK110.39952769
105STK160.39906287
106RPS6KA40.39622905
107LRRK20.39019565
108TAOK30.38619066
109PAK10.38369234
110BRD40.38315426
111MAP3K110.38009787
112PRKAA10.37417308
113VRK10.37193999
114ADRBK10.37172889
115FER0.37077852
116RPS6KC10.36346129
117RPS6KL10.36346129
118AURKB0.35950599
119PRKCD0.35017733
120MAP3K30.34118051
121TGFBR20.33907778
122CDK80.31711671
123PRKCZ0.31076902
124MELK0.30569072
125RPS6KA10.29127863
126CDK40.28860666
127IRAK30.28609996
128WNK30.28358963
129SIK10.26351497
130PRKACA0.26287953
131NEK60.24866314
132PRKCH0.24416567
133PAK40.24143572
134BMPR1B0.24102798
135RIPK10.23309122
136TAOK10.22057846
137DYRK20.21565273
138PRKCA0.21491033
139CDK20.20985202
140MAPK80.19511908
141MAP2K10.19328871
142LYN0.19207121
143ZAP700.19192918
144PIM20.18907373
145CDK30.18630095
146RPS6KB10.18627428
147PLK30.17999521
148MAPKAPK20.17430102
149IRAK20.17316705
150RPS6KA50.17256451
151CDK10.17175155
152CHUK0.15743043
153RPS6KA20.15564602
154SRPK10.14663932
155PDPK10.13787861
156STK38L0.12943648
157CSNK2A10.12661612
158PIM10.12306833
159NTRK20.11648511
160PRKCG0.11520414
161CDK60.11369242
162YES10.11033375
163CDC42BPA0.09802846
164PAK20.09509784
165FGFR40.08938108
166PINK10.08086593
167BRAF0.07722629
168MAPKAPK50.07676803
169PKN10.07670279

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007504.02303879
2Selenocompound metabolism_Homo sapiens_hsa004503.40817324
3Pyruvate metabolism_Homo sapiens_hsa006203.34100344
4Histidine metabolism_Homo sapiens_hsa003403.32733494
5Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.17952672
6Propanoate metabolism_Homo sapiens_hsa006402.72736642
7Tyrosine metabolism_Homo sapiens_hsa003502.51631026
8Maturity onset diabetes of the young_Homo sapiens_hsa049502.50889811
9Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.46182197
10Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.28970768
11alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.17227918
12Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.14055218
13DNA replication_Homo sapiens_hsa030302.12464831
14Linoleic acid metabolism_Homo sapiens_hsa005912.10870300
15Fatty acid biosynthesis_Homo sapiens_hsa000612.09847309
16beta-Alanine metabolism_Homo sapiens_hsa004102.06528041
17Phototransduction_Homo sapiens_hsa047442.00513377
18Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.00134951
19Glucagon signaling pathway_Homo sapiens_hsa049221.98329721
20Pentose phosphate pathway_Homo sapiens_hsa000301.95863007
21Basal transcription factors_Homo sapiens_hsa030221.94441473
22Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.92464531
23Carbohydrate digestion and absorption_Homo sapiens_hsa049731.92224666
24Intestinal immune network for IgA production_Homo sapiens_hsa046721.85511631
25Fanconi anemia pathway_Homo sapiens_hsa034601.85253427
26Glycerolipid metabolism_Homo sapiens_hsa005611.80543517
27Fatty acid degradation_Homo sapiens_hsa000711.79043688
28Fat digestion and absorption_Homo sapiens_hsa049751.77360828
29Caffeine metabolism_Homo sapiens_hsa002321.73733169
30PPAR signaling pathway_Homo sapiens_hsa033201.57982814
31RNA transport_Homo sapiens_hsa030131.54909149
32Notch signaling pathway_Homo sapiens_hsa043301.53729451
33Cysteine and methionine metabolism_Homo sapiens_hsa002701.53319894
34Mismatch repair_Homo sapiens_hsa034301.47676801
35Carbon metabolism_Homo sapiens_hsa012001.47015467
36Fructose and mannose metabolism_Homo sapiens_hsa000511.45891991
37Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.45844675
38Asthma_Homo sapiens_hsa053101.45591225
39Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.45414223
40Fatty acid metabolism_Homo sapiens_hsa012121.40155604
41Type I diabetes mellitus_Homo sapiens_hsa049401.39234711
42Base excision repair_Homo sapiens_hsa034101.37629155
43Taste transduction_Homo sapiens_hsa047421.33329238
44Nitrogen metabolism_Homo sapiens_hsa009101.31036385
45Allograft rejection_Homo sapiens_hsa053301.30633604
46Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.30240688
47Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.29155729
48Autoimmune thyroid disease_Homo sapiens_hsa053201.27624010
49Sphingolipid metabolism_Homo sapiens_hsa006001.27580802
50Cell cycle_Homo sapiens_hsa041101.27513586
51Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.23979856
52mRNA surveillance pathway_Homo sapiens_hsa030151.23828722
53Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.23736534
54Biosynthesis of amino acids_Homo sapiens_hsa012301.23257933
55Glutathione metabolism_Homo sapiens_hsa004801.23209168
56Pyrimidine metabolism_Homo sapiens_hsa002401.20960827
57Dorso-ventral axis formation_Homo sapiens_hsa043201.18494367
58Systemic lupus erythematosus_Homo sapiens_hsa053221.17477041
59ABC transporters_Homo sapiens_hsa020101.16435476
60Spliceosome_Homo sapiens_hsa030401.14890859
61Glycerophospholipid metabolism_Homo sapiens_hsa005641.14709054
62Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.13333238
63Oocyte meiosis_Homo sapiens_hsa041141.12254566
64Graft-versus-host disease_Homo sapiens_hsa053321.10612978
65Nucleotide excision repair_Homo sapiens_hsa034201.08736957
66Purine metabolism_Homo sapiens_hsa002301.07853644
67Huntingtons disease_Homo sapiens_hsa050161.05409085
68Salivary secretion_Homo sapiens_hsa049701.05215223
69Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.04502817
70Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.03260374
71Primary bile acid biosynthesis_Homo sapiens_hsa001201.01194433
72Homologous recombination_Homo sapiens_hsa034401.00595323
73Olfactory transduction_Homo sapiens_hsa047400.99439621
74Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.98574256
75Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.98573901
76Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.98406314
77Collecting duct acid secretion_Homo sapiens_hsa049660.95880309
78Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.94980785
79Steroid hormone biosynthesis_Homo sapiens_hsa001400.94503187
80Antigen processing and presentation_Homo sapiens_hsa046120.94180804
81N-Glycan biosynthesis_Homo sapiens_hsa005100.94007182
82Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.93469867
83Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.92658206
84Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.91164819
85Regulation of autophagy_Homo sapiens_hsa041400.89119438
86Sulfur relay system_Homo sapiens_hsa041220.88194879
87Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.87358805
88Chemical carcinogenesis_Homo sapiens_hsa052040.85564755
89Sulfur metabolism_Homo sapiens_hsa009200.84299561
90Tryptophan metabolism_Homo sapiens_hsa003800.80932477
91Oxidative phosphorylation_Homo sapiens_hsa001900.80567861
92Glycosaminoglycan degradation_Homo sapiens_hsa005310.79627247
93Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.78371414
94Peroxisome_Homo sapiens_hsa041460.77486161
95Nicotine addiction_Homo sapiens_hsa050330.76754425
96Drug metabolism - other enzymes_Homo sapiens_hsa009830.73511998
97Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.72118415
98Pentose and glucuronate interconversions_Homo sapiens_hsa000400.71794923
99Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.70517362
100Hedgehog signaling pathway_Homo sapiens_hsa043400.70274804
101Insulin secretion_Homo sapiens_hsa049110.69935075
102RNA degradation_Homo sapiens_hsa030180.69561515
103Tight junction_Homo sapiens_hsa045300.66999884
104Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.65355015
105AMPK signaling pathway_Homo sapiens_hsa041520.65020799
106Lysine degradation_Homo sapiens_hsa003100.64226117
107Cyanoamino acid metabolism_Homo sapiens_hsa004600.63747851
108Primary immunodeficiency_Homo sapiens_hsa053400.63424480
109Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.62648919
110Ovarian steroidogenesis_Homo sapiens_hsa049130.62371784
111Arachidonic acid metabolism_Homo sapiens_hsa005900.61149913
112Hepatitis C_Homo sapiens_hsa051600.60675393
113RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.60254079
114Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.60065065
115Ether lipid metabolism_Homo sapiens_hsa005650.58804630
116Retinol metabolism_Homo sapiens_hsa008300.58366425
117Metabolic pathways_Homo sapiens_hsa011000.57616522
118Choline metabolism in cancer_Homo sapiens_hsa052310.56290822
119Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.54132478
120Arginine and proline metabolism_Homo sapiens_hsa003300.53914237
121Cardiac muscle contraction_Homo sapiens_hsa042600.52414653
122Calcium signaling pathway_Homo sapiens_hsa040200.51646715
123Serotonergic synapse_Homo sapiens_hsa047260.49859817
124Alcoholism_Homo sapiens_hsa050340.49329924
125Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.48838727
126Insulin resistance_Homo sapiens_hsa049310.48834268
127Mineral absorption_Homo sapiens_hsa049780.48713097
128Adipocytokine signaling pathway_Homo sapiens_hsa049200.48614814
129Vitamin digestion and absorption_Homo sapiens_hsa049770.48096088
130Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.46647420
131Jak-STAT signaling pathway_Homo sapiens_hsa046300.46101355
132Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.46082337
133Basal cell carcinoma_Homo sapiens_hsa052170.44057287
134Bile secretion_Homo sapiens_hsa049760.43955802
135Central carbon metabolism in cancer_Homo sapiens_hsa052300.41547134
136Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.41082257
137Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.40404415
138One carbon pool by folate_Homo sapiens_hsa006700.39477575
139Viral carcinogenesis_Homo sapiens_hsa052030.36658245
140Protein export_Homo sapiens_hsa030600.36552044
141T cell receptor signaling pathway_Homo sapiens_hsa046600.34389014
142Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.34368349
143Circadian entrainment_Homo sapiens_hsa047130.33807931
144Hematopoietic cell lineage_Homo sapiens_hsa046400.33675408
145NOD-like receptor signaling pathway_Homo sapiens_hsa046210.33658168
146Rheumatoid arthritis_Homo sapiens_hsa053230.33170153
147Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.32836210
148VEGF signaling pathway_Homo sapiens_hsa043700.32087000
149Type II diabetes mellitus_Homo sapiens_hsa049300.30781577
150Butanoate metabolism_Homo sapiens_hsa006500.29981571
151RNA polymerase_Homo sapiens_hsa030200.29720516
152cAMP signaling pathway_Homo sapiens_hsa040240.29613174
153Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.29586171
154Thyroid hormone synthesis_Homo sapiens_hsa049180.29340868
155Circadian rhythm_Homo sapiens_hsa047100.28484818
156Cocaine addiction_Homo sapiens_hsa050300.28157387
157Complement and coagulation cascades_Homo sapiens_hsa046100.27463179
158Oxytocin signaling pathway_Homo sapiens_hsa049210.26883615
159B cell receptor signaling pathway_Homo sapiens_hsa046620.26191237
160Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.25933245
161Phenylalanine metabolism_Homo sapiens_hsa003600.25757701
162Epstein-Barr virus infection_Homo sapiens_hsa051690.25638153
163Aldosterone synthesis and secretion_Homo sapiens_hsa049250.25621729
164Glutamatergic synapse_Homo sapiens_hsa047240.22907013

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