LRRC57

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fucose catabolic process (GO:0019317)6.67397263
2L-fucose metabolic process (GO:0042354)6.67397263
3L-fucose catabolic process (GO:0042355)6.67397263
4behavioral response to nicotine (GO:0035095)6.26657518
5sperm motility (GO:0030317)5.32958982
6acrosome reaction (GO:0007340)4.94137296
7regulation of cilium movement (GO:0003352)4.83035988
8protein neddylation (GO:0045116)4.77340612
9fusion of sperm to egg plasma membrane (GO:0007342)4.63428129
10multicellular organism reproduction (GO:0032504)4.56421035
11chaperone-mediated protein transport (GO:0072321)4.37240809
12negative regulation of inclusion body assembly (GO:0090084)4.35969173
13protein deneddylation (GO:0000338)4.26144264
14sperm-egg recognition (GO:0035036)4.25688452
15indole-containing compound catabolic process (GO:0042436)4.21580326
16indolalkylamine catabolic process (GO:0046218)4.21580326
17tryptophan catabolic process (GO:0006569)4.21580326
18kynurenine metabolic process (GO:0070189)4.13250808
19response to pheromone (GO:0019236)4.11897355
20spermatid development (GO:0007286)4.11327556
21presynaptic membrane assembly (GO:0097105)4.08588726
22epithelial cilium movement (GO:0003351)4.04772910
23indolalkylamine metabolic process (GO:0006586)4.03172044
24cullin deneddylation (GO:0010388)4.00427290
25binding of sperm to zona pellucida (GO:0007339)3.97194077
26plasma membrane fusion (GO:0045026)3.95700951
27microtubule depolymerization (GO:0007019)3.85156004
28positive regulation of mitochondrial fission (GO:0090141)3.81346438
29cell-cell recognition (GO:0009988)3.78831733
30cell wall macromolecule catabolic process (GO:0016998)3.77143090
31cell wall macromolecule metabolic process (GO:0044036)3.77143090
32microtubule polymerization or depolymerization (GO:0031109)3.75493064
33microtubule severing (GO:0051013)3.73277713
34L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.72571526
35axonemal dynein complex assembly (GO:0070286)3.69116001
36tryptophan metabolic process (GO:0006568)3.65719987
37presynaptic membrane organization (GO:0097090)3.64811217
38calcium ion-dependent exocytosis (GO:0017156)3.63379373
39protein prenylation (GO:0018342)3.60557205
40prenylation (GO:0097354)3.60557205
41regulation of inclusion body assembly (GO:0090083)3.60289936
42fucosylation (GO:0036065)3.58174461
43detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.58081060
44piRNA metabolic process (GO:0034587)3.56814983
45acrosome assembly (GO:0001675)3.52546161
46reproduction (GO:0000003)3.49137075
47single fertilization (GO:0007338)3.46201003
48protein polyglutamylation (GO:0018095)3.45274664
49sulfation (GO:0051923)3.43716351
50ATP hydrolysis coupled proton transport (GO:0015991)3.42349762
51energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.42349762
52detection of light stimulus involved in visual perception (GO:0050908)3.39248038
53detection of light stimulus involved in sensory perception (GO:0050962)3.39248038
54transferrin transport (GO:0033572)3.38296999
55male meiosis (GO:0007140)3.37261619
56motile cilium assembly (GO:0044458)3.37110867
57negative regulation of telomere maintenance (GO:0032205)3.31054218
58DNA deamination (GO:0045006)3.29874106
59protein import into peroxisome matrix (GO:0016558)3.29058688
607-methylguanosine mRNA capping (GO:0006370)3.25322785
61cellular ketone body metabolic process (GO:0046950)3.25198508
62mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)3.24032687
63positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021103.24032687
64indole-containing compound metabolic process (GO:0042430)3.20561392
65regulation of mitotic spindle checkpoint (GO:1903504)3.19690219
66regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.19690219
67negative regulation of dendrite morphogenesis (GO:0050774)3.17801758
68polyol catabolic process (GO:0046174)3.16190566
69synaptonemal complex organization (GO:0070193)3.16108894
707-methylguanosine RNA capping (GO:0009452)3.15282235
71RNA capping (GO:0036260)3.15282235
72negative regulation of translation, ncRNA-mediated (GO:0040033)3.14273302
73regulation of translation, ncRNA-mediated (GO:0045974)3.14273302
74negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.14273302
75neural tube formation (GO:0001841)3.13877345
76L-methionine salvage (GO:0071267)3.13549127
77L-methionine biosynthetic process (GO:0071265)3.13549127
78amino acid salvage (GO:0043102)3.13549127
79preassembly of GPI anchor in ER membrane (GO:0016254)3.12393171
80synaptic vesicle docking involved in exocytosis (GO:0016081)3.11045679
81cilium movement (GO:0003341)3.08398053
82ferric iron transport (GO:0015682)3.06936028
83trivalent inorganic cation transport (GO:0072512)3.06936028
84oxidative demethylation (GO:0070989)3.06759476
85glutamate secretion (GO:0014047)3.06644438
86regulation of hippo signaling (GO:0035330)3.06099052
87negative regulation of mast cell activation (GO:0033004)3.05852362
88mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.04964336
89mitochondrial respiratory chain complex I assembly (GO:0032981)3.04964336
90NADH dehydrogenase complex assembly (GO:0010257)3.04964336
91primary amino compound metabolic process (GO:1901160)3.04894524
92regulation of spindle checkpoint (GO:0090231)3.04885367
93protein refolding (GO:0042026)3.03141620
94water-soluble vitamin biosynthetic process (GO:0042364)3.00968027
95serotonin metabolic process (GO:0042428)3.00854697
96synaptonemal complex assembly (GO:0007130)2.99943171
97epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.98556561
98nonmotile primary cilium assembly (GO:0035058)2.96791576
99synaptic vesicle exocytosis (GO:0016079)2.96326980
100inositol phosphate catabolic process (GO:0071545)2.96233446
101protein complex biogenesis (GO:0070271)2.95820877
102sperm capacitation (GO:0048240)2.95574952
103NAD biosynthetic process (GO:0009435)2.94993126
104monoubiquitinated protein deubiquitination (GO:0035520)2.93869531
105ketone body metabolic process (GO:1902224)2.93577003
106behavioral response to ethanol (GO:0048149)2.93547315
107signal peptide processing (GO:0006465)2.92893314
108recombinational repair (GO:0000725)2.92401481
109neuron cell-cell adhesion (GO:0007158)2.91769625
110double-strand break repair via homologous recombination (GO:0000724)2.91643569
111neuronal action potential (GO:0019228)2.90500955
112male meiosis I (GO:0007141)2.89799058
113negative regulation of synaptic transmission, GABAergic (GO:0032229)2.87717575
114reciprocal DNA recombination (GO:0035825)2.87277626
115reciprocal meiotic recombination (GO:0007131)2.87277626
116regulation of rhodopsin mediated signaling pathway (GO:0022400)2.86495111
117regulation of mitochondrial fission (GO:0090140)2.83285199
118rhodopsin mediated signaling pathway (GO:0016056)2.82995144
119fertilization (GO:0009566)2.82221795
120reflex (GO:0060004)2.81125050
121fatty acid elongation (GO:0030497)2.80840644
122protein localization to cilium (GO:0061512)2.80749966
123cilium or flagellum-dependent cell motility (GO:0001539)2.80418729
124response to redox state (GO:0051775)2.79152804
125neuronal action potential propagation (GO:0019227)2.78031875
126amine catabolic process (GO:0009310)2.77658009
127cellular biogenic amine catabolic process (GO:0042402)2.77658009
128male gamete generation (GO:0048232)2.77128588
129spermatogenesis (GO:0007283)2.76928705
130regulation of synaptic vesicle exocytosis (GO:2000300)2.75707114
131gamma-aminobutyric acid transport (GO:0015812)2.75507880
132kidney morphogenesis (GO:0060993)2.75003007
133rRNA catabolic process (GO:0016075)2.73783011
134regulation of mesoderm development (GO:2000380)2.73751509
135fucose metabolic process (GO:0006004)2.73576790
136regulation of nuclear cell cycle DNA replication (GO:0033262)2.72666826
137negative regulation of neurotransmitter transport (GO:0051589)2.72308946
138mitochondrial fission (GO:0000266)2.72036979
139axoneme assembly (GO:0035082)2.71420287
140replication fork processing (GO:0031297)2.69479052
141gamete generation (GO:0007276)2.68182205
142DNA demethylation (GO:0080111)2.68151856
143spermatid nucleus differentiation (GO:0007289)2.66675106
144platelet dense granule organization (GO:0060155)2.66650733
145cilium morphogenesis (GO:0060271)2.66164761
146respiratory chain complex IV assembly (GO:0008535)2.64866652
147GMP metabolic process (GO:0046037)2.64535815
148neurotransmitter uptake (GO:0001504)2.64120560
149cilium organization (GO:0044782)2.63067903
150meiosis I (GO:0007127)2.62102351
151regulation of synaptic vesicle transport (GO:1902803)2.62085313
152protein K11-linked deubiquitination (GO:0035871)2.61649725
153ubiquinone biosynthetic process (GO:0006744)2.60629738
154transcription elongation from RNA polymerase II promoter (GO:0006368)2.60595469
155regulation of microtubule-based movement (GO:0060632)2.60590736
156long-chain fatty acid biosynthetic process (GO:0042759)2.60307187
157negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.59649100
158cornea development in camera-type eye (GO:0061303)2.57892219
159mitochondrial respiratory chain complex assembly (GO:0033108)2.57819466
160regulation of action potential (GO:0098900)2.57533257
161regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902108)2.57433656
162mitotic metaphase plate congression (GO:0007080)2.57388088
163regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.57274003
164negative regulation of transcription regulatory region DNA binding (GO:2000678)2.56861425
165cilium assembly (GO:0042384)2.56702094
166photoreceptor cell maintenance (GO:0045494)2.55946270
167positive regulation of mitochondrial membrane permeability (GO:0035794)2.55602863
168RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.54541521
169regulation of posttranscriptional gene silencing (GO:0060147)2.54220582
170regulation of gene silencing by miRNA (GO:0060964)2.54220582
171regulation of gene silencing by RNA (GO:0060966)2.54220582
172cellular response to ATP (GO:0071318)2.53621079
173anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.53527698
174regulation of meiosis I (GO:0060631)2.52107387
175negative regulation of systemic arterial blood pressure (GO:0003085)2.51732218
176retinal cone cell development (GO:0046549)2.51041475
177negative regulation of DNA-dependent DNA replication (GO:2000104)2.50757961
178purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.49083891
1793-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.49083891
180negative regulation of reactive oxygen species metabolic process (GO:2000378)2.47207343
181synaptic transmission, cholinergic (GO:0007271)2.46716108
182ubiquinone metabolic process (GO:0006743)2.46010341
183nephron epithelium morphogenesis (GO:0072088)2.43212679
184nephron tubule morphogenesis (GO:0072078)2.43212679
185proline transport (GO:0015824)2.42477595
186positive regulation of oligodendrocyte differentiation (GO:0048714)2.41870743
187G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.40409055
188histone-serine phosphorylation (GO:0035404)2.40281738
189positive regulation of developmental pigmentation (GO:0048087)2.39657284

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela4.21923408
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.12194265
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.39684627
4CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.35855482
5VDR_22108803_ChIP-Seq_LS180_Human3.14372322
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.04771250
7RBPJ_22232070_ChIP-Seq_NCS_Mouse2.75992168
8TAF15_26573619_Chip-Seq_HEK293_Human2.65900847
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.62127682
10EZH2_22144423_ChIP-Seq_EOC_Human2.59199414
11GBX2_23144817_ChIP-Seq_PC3_Human2.54707713
12FLI1_27457419_Chip-Seq_LIVER_Mouse2.49162951
13IGF1R_20145208_ChIP-Seq_DFB_Human2.36923090
14GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.31335459
15ZFP57_27257070_Chip-Seq_ESCs_Mouse2.25664937
16FUS_26573619_Chip-Seq_HEK293_Human2.19454015
17HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.18754494
18RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.18701430
19GABP_17652178_ChIP-ChIP_JURKAT_Human2.16126730
20SALL1_21062744_ChIP-ChIP_HESCs_Human2.11772168
21EST1_17652178_ChIP-ChIP_JURKAT_Human2.10499725
22* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.08613379
23NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.06231612
24POU3F2_20337985_ChIP-ChIP_501MEL_Human2.05873864
25PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.05075947
26MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.01253026
27NOTCH1_21737748_ChIP-Seq_TLL_Human1.94342329
28PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.92631115
29CTBP2_25329375_ChIP-Seq_LNCAP_Human1.87171412
30PCGF2_27294783_Chip-Seq_ESCs_Mouse1.86503810
31EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.84054408
32HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.75675403
33CREB1_15753290_ChIP-ChIP_HEK293T_Human1.65482504
34BCAT_22108803_ChIP-Seq_LS180_Human1.64685664
35P300_19829295_ChIP-Seq_ESCs_Human1.61174963
36NR3C1_21868756_ChIP-Seq_MCF10A_Human1.57117846
37POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.55291205
38TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.55291205
39ER_23166858_ChIP-Seq_MCF-7_Human1.55017212
40MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.52388203
41NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.49969105
42TP53_22573176_ChIP-Seq_HFKS_Human1.48083479
43PCGF2_27294783_Chip-Seq_NPCs_Mouse1.47636980
44GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.46867913
45REST_21632747_ChIP-Seq_MESCs_Mouse1.44445918
46SRF_21415370_ChIP-Seq_HL-1_Mouse1.43324125
47BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.43245874
48PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.42085670
49CTBP1_25329375_ChIP-Seq_LNCAP_Human1.42085238
50KAP1_22055183_ChIP-Seq_ESCs_Mouse1.40895202
51CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.40824886
52ETS1_20019798_ChIP-Seq_JURKAT_Human1.38718319
53NANOG_18555785_Chip-Seq_ESCs_Mouse1.36790612
54TAL1_26923725_Chip-Seq_HPCs_Mouse1.36038129
55* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35946127
56BMI1_23680149_ChIP-Seq_NPCS_Mouse1.35232050
57FOXA1_27270436_Chip-Seq_PROSTATE_Human1.34443997
58FOXA1_25329375_ChIP-Seq_VCAP_Human1.34443997
59AR_21572438_ChIP-Seq_LNCaP_Human1.33895092
60TP53_16413492_ChIP-PET_HCT116_Human1.33467186
61SMAD4_21799915_ChIP-Seq_A2780_Human1.32991228
62OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32912462
63GATA1_22025678_ChIP-Seq_K562_Human1.32311648
64SOX2_19829295_ChIP-Seq_ESCs_Human1.32027488
65NANOG_19829295_ChIP-Seq_ESCs_Human1.32027488
66TCF4_22108803_ChIP-Seq_LS180_Human1.28990827
67RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.27621776
68SUZ12_27294783_Chip-Seq_NPCs_Mouse1.26977069
69THAP11_20581084_ChIP-Seq_MESCs_Mouse1.26362128
70FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.25593281
71SOX9_26525672_Chip-Seq_HEART_Mouse1.25198643
72GATA3_21878914_ChIP-Seq_MCF-7_Human1.24105750
73* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.23201311
74RNF2_27304074_Chip-Seq_NSC_Mouse1.22791771
75KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.22674296
76SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.22342897
77YY1_21170310_ChIP-Seq_MESCs_Mouse1.21796153
78MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.20821922
79NFE2_27457419_Chip-Seq_LIVER_Mouse1.20200638
80RUNX2_22187159_ChIP-Seq_PCA_Human1.20072453
81MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.19764068
82FOXA1_21572438_ChIP-Seq_LNCaP_Human1.19310302
83* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.18490750
84UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.18328019
85ETV2_25802403_ChIP-Seq_MESCs_Mouse1.18325463
86CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16787827
87MYC_18940864_ChIP-ChIP_HL60_Human1.16598455
88KLF5_20875108_ChIP-Seq_MESCs_Mouse1.16358647
89PRDM14_20953172_ChIP-Seq_ESCs_Human1.16120807
90* STAT3_18555785_Chip-Seq_ESCs_Mouse1.14650955
91JUN_21703547_ChIP-Seq_K562_Human1.14245642
92NCOR_22424771_ChIP-Seq_293T_Human1.13223932
93SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.12633774
94GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.12212844
95* P53_22387025_ChIP-Seq_ESCs_Mouse1.11575662
96AR_20517297_ChIP-Seq_VCAP_Human1.10866272
97SMAD4_21741376_ChIP-Seq_EPCs_Human1.10616939
98TOP2B_26459242_ChIP-Seq_MCF-7_Human1.10534726
99GATA1_26923725_Chip-Seq_HPCs_Mouse1.10330377
100EWS_26573619_Chip-Seq_HEK293_Human1.10157618
101AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.08219745
102CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.08104026
103* CMYC_18555785_Chip-Seq_ESCs_Mouse1.07698417
104TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.07572238
105HOXB7_26014856_ChIP-Seq_BT474_Human1.06399889
106EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.06230718
107* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.05556355
108CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.05106338
109REST_18959480_ChIP-ChIP_MESCs_Mouse1.04089690
110SMAD_19615063_ChIP-ChIP_OVARY_Human1.03875840
111CRX_20693478_ChIP-Seq_RETINA_Mouse1.02879824
112* E2F1_18555785_Chip-Seq_ESCs_Mouse1.02635018
113FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.01466493
114TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01161321
115RUNX1_27457419_Chip-Seq_LIVER_Mouse1.01146754
116* SOX2_18555785_Chip-Seq_ESCs_Mouse1.00918455
117EGR1_23403033_ChIP-Seq_LIVER_Mouse1.00283540
118TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.00218815
119TCF4_23295773_ChIP-Seq_U87_Human0.99038947
120* P300_18555785_Chip-Seq_ESCs_Mouse0.98398117
121SMAD3_21741376_ChIP-Seq_EPCs_Human0.98043346
122STAT3_23295773_ChIP-Seq_U87_Human0.97988478
123AR_25329375_ChIP-Seq_VCAP_Human0.97522390
124FLI1_21867929_ChIP-Seq_TH2_Mouse0.97208892
125IRF1_19129219_ChIP-ChIP_H3396_Human0.96794852
126PIAS1_25552417_ChIP-Seq_VCAP_Human0.96497431
127CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.96294245
128ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.95916395
129CDX2_22108803_ChIP-Seq_LS180_Human0.95593831
130VDR_23849224_ChIP-Seq_CD4+_Human0.95098622
131PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95084964
132REST_19997604_ChIP-ChIP_NEURONS_Mouse0.93520420
133* NMYC_18555785_Chip-Seq_ESCs_Mouse0.93461127
134CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.93450877
135KDM2B_26808549_Chip-Seq_REH_Human0.92032439
136CBX2_27304074_Chip-Seq_ESCs_Mouse0.91963892
137AUTS2_25519132_ChIP-Seq_293T-REX_Human0.91905906
138IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.91299451
139CBP_20019798_ChIP-Seq_JUKART_Human0.91299451
140* KLF4_18555785_Chip-Seq_ESCs_Mouse0.90914598
141EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.90371908
142CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.90170536
143BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.90146988
144RXR_22108803_ChIP-Seq_LS180_Human0.90087698
145TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.90064448
146EZH2_27294783_Chip-Seq_NPCs_Mouse0.90042080
147* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.89043122

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization5.31020923
2MP0003880_abnormal_central_pattern4.99805702
3MP0008877_abnormal_DNA_methylation3.39631625
4MP0003195_calcinosis3.38448773
5MP0000569_abnormal_digit_pigmentation3.08899241
6MP0004270_analgesia2.95183399
7MP0002736_abnormal_nociception_after2.66863628
8MP0005646_abnormal_pituitary_gland2.66037749
9MP0004147_increased_porphyrin_level2.65146937
10MP0001905_abnormal_dopamine_level2.62347989
11MP0004859_abnormal_synaptic_plasticity2.56693866
12MP0001529_abnormal_vocalization2.48989282
13MP0001968_abnormal_touch/_nociception2.45453376
14MP0003718_maternal_effect2.40002615
15MP0003698_abnormal_male_reproductive2.30912741
16MP0003787_abnormal_imprinting2.30033197
17MP0001929_abnormal_gametogenesis2.23950942
18MP0002734_abnormal_mechanical_nocicepti2.22242171
19MP0009046_muscle_twitch2.21546634
20MP0008260_abnormal_autophagy2.15672526
21MP0000427_abnormal_hair_cycle2.04193320
22MP0002272_abnormal_nervous_system1.98756010
23MP0003635_abnormal_synaptic_transmissio1.98171547
24MP0002064_seizures1.92844405
25MP0000383_abnormal_hair_follicle1.88009423
26MP0002735_abnormal_chemical_nociception1.86334804
27MP0001984_abnormal_olfaction1.85950781
28MP0008872_abnormal_physiological_respon1.85874112
29MP0009745_abnormal_behavioral_response1.84219844
30MP0006072_abnormal_retinal_apoptosis1.80581658
31MP0002572_abnormal_emotion/affect_behav1.76930819
32MP0003950_abnormal_plasma_membrane1.74289267
33MP0001440_abnormal_grooming_behavior1.73510872
34MP0002160_abnormal_reproductive_system1.69493229
35MP0002063_abnormal_learning/memory/cond1.68596775
36MP0002837_dystrophic_cardiac_calcinosis1.68331720
37MP0000566_synostosis1.68158326
38MP0008875_abnormal_xenobiotic_pharmacok1.67041366
39MP0006276_abnormal_autonomic_nervous1.66359785
40MP0002938_white_spotting1.65228899
41MP0005174_abnormal_tail_pigmentation1.61142063
42MP0002210_abnormal_sex_determination1.58079553
43MP0009697_abnormal_copulation1.56891037
44MP0005171_absent_coat_pigmentation1.55310394
45MP0000372_irregular_coat_pigmentation1.52682657
46MP0003646_muscle_fatigue1.48893521
47MP0005645_abnormal_hypothalamus_physiol1.48482004
48MP0003879_abnormal_hair_cell1.48260278
49MP0003136_yellow_coat_color1.48060120
50MP0008058_abnormal_DNA_repair1.42796517
51MP0002161_abnormal_fertility/fecundity1.41833540
52MP0004133_heterotaxia1.41672110
53MP0002067_abnormal_sensory_capabilities1.40984006
54MP0002876_abnormal_thyroid_physiology1.38924973
55MP0002638_abnormal_pupillary_reflex1.37385454
56MP0003011_delayed_dark_adaptation1.35964172
57MP0000653_abnormal_sex_gland1.34112351
58MP0003806_abnormal_nucleotide_metabolis1.33796346
59MP0002234_abnormal_pharynx_morphology1.32054480
60MP0001145_abnormal_male_reproductive1.31936215
61MP0001919_abnormal_reproductive_system1.29670613
62MP0002653_abnormal_ependyma_morphology1.28137587
63MP0005084_abnormal_gallbladder_morpholo1.26931333
64MP0001970_abnormal_pain_threshold1.26838270
65MP0000631_abnormal_neuroendocrine_gland1.25389005
66MP0001486_abnormal_startle_reflex1.24026437
67MP0004924_abnormal_behavior1.23879631
68MP0005386_behavior/neurological_phenoty1.23879631
69MP0005551_abnormal_eye_electrophysiolog1.23165070
70MP0006292_abnormal_olfactory_placode1.22560129
71MP0005451_abnormal_body_composition1.22216661
72MP0009780_abnormal_chondrocyte_physiolo1.18495408
73MP0002751_abnormal_autonomic_nervous1.16232363
74MP0002095_abnormal_skin_pigmentation1.14638681
75MP0002733_abnormal_thermal_nociception1.13168776
76MP0001986_abnormal_taste_sensitivity1.13059676
77MP0010386_abnormal_urinary_bladder1.12284160
78MP0008057_abnormal_DNA_replication1.12240986
79MP0002822_catalepsy1.11414472
80MP0002928_abnormal_bile_duct1.11073856
81MP0000538_abnormal_urinary_bladder1.10621992
82MP0005195_abnormal_posterior_eye1.08299764
83MP0000230_abnormal_systemic_arterial1.08091119
84MP0005389_reproductive_system_phenotype1.06669975
85MP0001188_hyperpigmentation1.05468571
86MP0008775_abnormal_heart_ventricle1.04692117
87MP0005167_abnormal_blood-brain_barrier1.03412131
88MP0000920_abnormal_myelination1.01836348
89MP0003937_abnormal_limbs/digits/tail_de1.00695688
90MP0003123_paternal_imprinting1.00432522
91MP0001764_abnormal_homeostasis1.00263303
92MP0004145_abnormal_muscle_electrophysio0.99872808
93MP0002229_neurodegeneration0.98115531
94MP0003283_abnormal_digestive_organ0.96821617
95MP0004130_abnormal_muscle_cell0.96663818
96MP0008961_abnormal_basal_metabolism0.96567532
97MP0001324_abnormal_eye_pigmentation0.96438605
98MP0005085_abnormal_gallbladder_physiolo0.95920458
99MP0003631_nervous_system_phenotype0.95527797
100MP0001664_abnormal_digestion0.94530470
101MP0001963_abnormal_hearing_physiology0.93455925
102MP0004142_abnormal_muscle_tone0.91286607
103MP0003121_genomic_imprinting0.90475950
104MP0008569_lethality_at_weaning0.89706622
105MP0010094_abnormal_chromosome_stability0.89411965
106MP0006035_abnormal_mitochondrial_morpho0.89360893
107MP0003329_amyloid_beta_deposits0.89222677
108MP0004036_abnormal_muscle_relaxation0.89148747
109MP0003633_abnormal_nervous_system0.88983172
110MP0004957_abnormal_blastocyst_morpholog0.88971988
111MP0006036_abnormal_mitochondrial_physio0.88898110
112MP0002138_abnormal_hepatobiliary_system0.88585195
113MP0003693_abnormal_embryo_hatching0.88364986
114MP0001501_abnormal_sleep_pattern0.88105230
115MP0000026_abnormal_inner_ear0.87916040
116MP0002163_abnormal_gland_morphology0.87656687
117MP0002066_abnormal_motor_capabilities/c0.87651032
118MP0008995_early_reproductive_senescence0.86433091
119MP0003119_abnormal_digestive_system0.86224209
120MP0003122_maternal_imprinting0.86179664
121MP0002752_abnormal_somatic_nervous0.86064273
122MP0001485_abnormal_pinna_reflex0.85097880
123MP0010678_abnormal_skin_adnexa0.84790762
124MP0003890_abnormal_embryonic-extraembry0.84712390
125MP0005266_abnormal_metabolism0.84632206
126MP0000647_abnormal_sebaceous_gland0.83708781
127MP0002882_abnormal_neuron_morphology0.81903326
128MP0003632_abnormal_nervous_system0.81260104
129MP0002277_abnormal_respiratory_mucosa0.80916848
130MP0000778_abnormal_nervous_system0.80041724
131MP0003786_premature_aging0.80012900
132MP0003252_abnormal_bile_duct0.79962934
133MP0002557_abnormal_social/conspecific_i0.79214397
134MP0001293_anophthalmia0.79089140
135MP0005377_hearing/vestibular/ear_phenot0.78633448
136MP0003878_abnormal_ear_physiology0.78633448
137MP0004885_abnormal_endolymph0.75033909
138MP0000749_muscle_degeneration0.74911507
139MP0002102_abnormal_ear_morphology0.74367591
140MP0005253_abnormal_eye_physiology0.73244302
141MP0008932_abnormal_embryonic_tissue0.71126506
142MP0001661_extended_life_span0.70439830
143MP0004215_abnormal_myocardial_fiber0.70064048
144MP0001542_abnormal_bone_strength0.69748104
145MP0004742_abnormal_vestibular_system0.68021738
146MP0003634_abnormal_glial_cell0.67975173
147MP0005395_other_phenotype0.66271763
148MP0005379_endocrine/exocrine_gland_phen0.65194895
149MP0004043_abnormal_pH_regulation0.65019419

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.68369386
2Absent/shortened dynein arms (HP:0200106)4.62008356
3Dynein arm defect of respiratory motile cilia (HP:0012255)4.62008356
4Congenital stationary night blindness (HP:0007642)4.14552851
5Focal motor seizures (HP:0011153)3.81171185
6Abnormal respiratory motile cilium morphology (HP:0005938)3.66320394
7Abnormal respiratory epithelium morphology (HP:0012253)3.66320394
8Birth length less than 3rd percentile (HP:0003561)3.51089281
9Atonic seizures (HP:0010819)3.47743119
10Cerebral hypomyelination (HP:0006808)3.41158762
11Abnormal respiratory motile cilium physiology (HP:0012261)3.40498987
12Increased serum pyruvate (HP:0003542)3.35830352
13Abnormality of glycolysis (HP:0004366)3.35830352
14Attenuation of retinal blood vessels (HP:0007843)3.33404177
15Large for gestational age (HP:0001520)3.32195222
16Abnormality of the renal cortex (HP:0011035)3.28334327
17Abnormality of the renal medulla (HP:0100957)3.24933582
18Epileptic encephalopathy (HP:0200134)3.24074225
19Infertility (HP:0000789)3.23642568
20Chronic hepatic failure (HP:0100626)3.13242690
21Pancreatic fibrosis (HP:0100732)3.07211580
22Acute necrotizing encephalopathy (HP:0006965)3.03307994
23Cystic liver disease (HP:0006706)3.01131147
24Rhinitis (HP:0012384)2.98286927
25Abnormal hair whorl (HP:0010721)2.93764792
26Tubular atrophy (HP:0000092)2.91490357
27Medial flaring of the eyebrow (HP:0010747)2.91173618
28Hepatocellular necrosis (HP:0001404)2.88407184
29Progressive macrocephaly (HP:0004481)2.82934397
30Genetic anticipation (HP:0003743)2.82280360
31Type II lissencephaly (HP:0007260)2.78372519
32Mitochondrial inheritance (HP:0001427)2.74430857
33Hyperventilation (HP:0002883)2.74312328
34Abolished electroretinogram (ERG) (HP:0000550)2.71818536
35Abnormal mitochondria in muscle tissue (HP:0008316)2.67852358
36Abnormal ciliary motility (HP:0012262)2.65429368
37Chronic bronchitis (HP:0004469)2.65150422
38Aplasia/Hypoplasia of the tibia (HP:0005772)2.63899469
39Congenital, generalized hypertrichosis (HP:0004540)2.62732797
40Furrowed tongue (HP:0000221)2.62623348
41Abnormality of the labia minora (HP:0012880)2.60844365
42Delusions (HP:0000746)2.60754929
43Congenital primary aphakia (HP:0007707)2.59901762
44Duplicated collecting system (HP:0000081)2.58068560
45Hypothermia (HP:0002045)2.57337739
46Methylmalonic acidemia (HP:0002912)2.55357838
47Hypoplasia of the capital femoral epiphysis (HP:0003090)2.55163281
48Decreased circulating renin level (HP:0003351)2.54520551
49Gait imbalance (HP:0002141)2.53951358
50Pendular nystagmus (HP:0012043)2.51534164
51Parakeratosis (HP:0001036)2.50279798
52Abnormality of the renal collecting system (HP:0004742)2.49999194
53Increased CSF lactate (HP:0002490)2.47244663
54Nephrogenic diabetes insipidus (HP:0009806)2.46734481
55Pheochromocytoma (HP:0002666)2.46551190
56Abnormal drinking behavior (HP:0030082)2.45524157
57Polydipsia (HP:0001959)2.45524157
58Increased corneal curvature (HP:0100692)2.45315799
59Keratoconus (HP:0000563)2.45315799
60Concave nail (HP:0001598)2.45121789
61Patellar aplasia (HP:0006443)2.40223396
62Neuroendocrine neoplasm (HP:0100634)2.39058538
63Aplasia/Hypoplasia of the patella (HP:0006498)2.37129177
64Acute encephalopathy (HP:0006846)2.35331017
65Poor coordination (HP:0002370)2.35227031
66Sclerocornea (HP:0000647)2.34742470
67Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.33856440
68Abnormality of alanine metabolism (HP:0010916)2.33856440
69Hyperalaninemia (HP:0003348)2.33856440
70Severe muscular hypotonia (HP:0006829)2.33656989
71Decreased central vision (HP:0007663)2.32729539
72Nephronophthisis (HP:0000090)2.30609901
73Congenital hepatic fibrosis (HP:0002612)2.28072038
74Chorioretinal atrophy (HP:0000533)2.27613075
75Aplasia/Hypoplasia of the tongue (HP:0010295)2.27508838
76Renal cortical cysts (HP:0000803)2.25879117
77Molar tooth sign on MRI (HP:0002419)2.24983136
78Abnormality of midbrain morphology (HP:0002418)2.24983136
79Anencephaly (HP:0002323)2.24589814
80Protruding tongue (HP:0010808)2.24203986
81Hepatic necrosis (HP:0002605)2.23571950
82Abnormal spermatogenesis (HP:0008669)2.23514983
83Breast hypoplasia (HP:0003187)2.23440819
84CNS hypomyelination (HP:0003429)2.22637658
85Male infertility (HP:0003251)2.21933150
86Decreased electroretinogram (ERG) amplitude (HP:0000654)2.21766142
87Abnormality of the pons (HP:0007361)2.19255190
88Bile duct proliferation (HP:0001408)2.18612111
89Abnormal biliary tract physiology (HP:0012439)2.18612111
90Lissencephaly (HP:0001339)2.16725035
91Bony spicule pigmentary retinopathy (HP:0007737)2.14772034
92Hypoplasia of the pons (HP:0012110)2.12844997
93Stomach cancer (HP:0012126)2.12402752
94Abnormal gallbladder physiology (HP:0012438)2.12049812
95Cholecystitis (HP:0001082)2.12049812
96Irregular epiphyses (HP:0010582)2.12025005
97Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.06420586
98Absent epiphyses (HP:0010577)2.06420586
99Fair hair (HP:0002286)2.06359719
100Clumsiness (HP:0002312)2.05115625
101Limb dystonia (HP:0002451)2.04381983
102Inability to walk (HP:0002540)2.04271926
103Cerebellar dysplasia (HP:0007033)2.04054200
104Male pseudohermaphroditism (HP:0000037)2.02210370
105Degeneration of the lateral corticospinal tracts (HP:0002314)2.02068766
106Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.02068766
107Genital tract atresia (HP:0001827)2.01343238
108Lactic acidosis (HP:0003128)2.00582100
109Decreased activity of mitochondrial respiratory chain (HP:0008972)2.00082217
110Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.00082217
111Bilateral microphthalmos (HP:0007633)1.98242038
112Abnormal rod and cone electroretinograms (HP:0008323)1.97566568
113Gaze-evoked nystagmus (HP:0000640)1.97552148
114Aplasia/Hypoplasia of the fovea (HP:0008060)1.96502057
115Hypoplasia of the fovea (HP:0007750)1.96502057
116Emotional lability (HP:0000712)1.96328736
117Increased serum lactate (HP:0002151)1.96214950
118Myokymia (HP:0002411)1.95272967
119Choroideremia (HP:0001139)1.94624116
120True hermaphroditism (HP:0010459)1.94494436
121Dialeptic seizures (HP:0011146)1.94417679
122Absence seizures (HP:0002121)1.94317424
123Retinal dysplasia (HP:0007973)1.93949053
124Vaginal atresia (HP:0000148)1.93525537
125Febrile seizures (HP:0002373)1.93503284
126Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.93444733
127Congenital sensorineural hearing impairment (HP:0008527)1.92809679
1283-Methylglutaconic aciduria (HP:0003535)1.91801559
129Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.90270659
130Methylmalonic aciduria (HP:0012120)1.90116842
131Sensory axonal neuropathy (HP:0003390)1.90026757
132CNS demyelination (HP:0007305)1.89829996
133Focal seizures (HP:0007359)1.89617769
134Progressive cerebellar ataxia (HP:0002073)1.89032985
135Polyuria (HP:0000103)1.87988498
136Widely spaced teeth (HP:0000687)1.87391376
137Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.86951004
138Unsteady gait (HP:0002317)1.86682935
139Postnatal microcephaly (HP:0005484)1.86150871
140Abnormality of the vitamin B12 metabolism (HP:0004341)1.84288084
141Fibular aplasia (HP:0002990)1.84095109
142Dysautonomia (HP:0002459)1.82868065
143Impulsivity (HP:0100710)1.82038885
144Partial agenesis of the corpus callosum (HP:0001338)1.81973962
145Generalized tonic-clonic seizures (HP:0002069)1.81315350
146Adactyly (HP:0009776)1.81264025
147Autoamputation (HP:0001218)1.81055256
148Aplasia/Hypoplasia of the uvula (HP:0010293)1.81047454
149Tachypnea (HP:0002789)1.80647709
150Leukodystrophy (HP:0002415)1.80218954
151Postaxial foot polydactyly (HP:0001830)1.80034897
152Increased hepatocellular lipid droplets (HP:0006565)1.79743757
153Clubbing of toes (HP:0100760)1.77140651
154Optic disc pallor (HP:0000543)1.76978379
155Hypoplastic left heart (HP:0004383)1.76415363
156Female pseudohermaphroditism (HP:0010458)1.76244878
157Pancreatic cysts (HP:0001737)1.74820996
158Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.72402463
159Abnormality of vitamin B metabolism (HP:0004340)1.71765695
160Adrenal hypoplasia (HP:0000835)1.71439012
161Hemiparesis (HP:0001269)1.71166954
162Broad-based gait (HP:0002136)1.71137102
163Progressive inability to walk (HP:0002505)1.69725489
164Absent speech (HP:0001344)1.68644477
165Small hand (HP:0200055)1.67905939
166Dandy-Walker malformation (HP:0001305)1.66719327
167Hypoplastic iliac wings (HP:0002866)1.66083752
168Short tibia (HP:0005736)1.65987597
169Optic nerve hypoplasia (HP:0000609)1.65708227
170Oligohydramnios (HP:0001562)1.65495334
171Generalized hypopigmentation of hair (HP:0011358)1.65121043

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.61227771
2CASK4.82360505
3AKT33.46276019
4ADRBK23.31444331
5INSRR2.90942241
6PDK42.82338212
7PDK32.82338212
8CCNB12.51839394
9ARAF2.47925193
10TLK12.37293316
11BUB12.35452333
12STK162.23314298
13MAP3K122.20712177
14EPHA42.20658996
15BRAF2.19617592
16WNK32.16411834
17PLK42.15605713
18PLK22.10750495
19CDK192.10282928
20MAP2K72.06515309
21PRKD32.05930678
22PDK21.99146114
23OXSR11.97701663
24TESK11.90051893
25NUAK11.89582727
26MAPKAPK51.85095765
27MAP4K21.74684379
28TSSK61.74224228
29TGFBR11.71457888
30PNCK1.71118668
31BCR1.56412028
32STK391.42232395
33MAP3K41.41647750
34BMPR21.39934298
35ADRBK11.37148003
36EIF2AK11.32683366
37TIE11.31757940
38MUSK1.30268543
39EIF2AK31.27110783
40DAPK21.26603849
41NEK61.25152113
42SRPK11.25076091
43MAP3K91.22040454
44BRSK21.19014219
45TXK1.14650764
46PLK31.13286354
47NTRK31.08530915
48MAPK131.07977486
49PINK11.06003832
50VRK11.05678772
51SIK31.03286650
52SGK4940.96584623
53SGK2230.96584623
54PRPF4B0.94355677
55PAK30.94205047
56GRK50.92843715
57SGK20.91876214
58CDK80.91449383
59TNIK0.90445493
60MKNK10.88886170
61DAPK10.86211958
62BMPR1B0.86148146
63PBK0.86043841
64PTK2B0.85797240
65CDK30.83684103
66CAMK2A0.82033905
67MYLK0.81776249
68MST40.81189077
69MAPK150.80600888
70PIK3CA0.78526580
71STK38L0.77334602
72CDC70.77134370
73TNK20.75481387
74MAPKAPK30.73151894
75CSNK1G30.72433665
76PRKCG0.72422082
77CDK180.71649961
78CDK140.71320605
79TRIM280.69969317
80STK240.69412021
81TTK0.69199795
82ACVR1B0.69185169
83MKNK20.67462948
84CSNK1G20.67414982
85TEC0.66750073
86DYRK1A0.64219838
87MAP3K110.64127539
88CAMK2B0.63886819
89MINK10.62717023
90CDK150.61874769
91LATS20.60834626
92MAPK70.60261419
93PRKCQ0.60162304
94LIMK10.59128173
95NME10.58165356
96ERBB40.57124178
97PDK10.56673729
98NEK20.55577291
99MOS0.54435210
100IKBKB0.53689041
101IRAK10.53494665
102KIT0.52607133
103PIK3CG0.51891828
104CAMK1D0.51661621
105CDK11A0.50274488
106PKN10.49572897
107DYRK20.48967412
108PDPK10.48212862
109RPS6KA50.48074207
110STK30.47431930
111TESK20.47287552
112CDK50.46421294
113MARK10.45965464
114MAP2K40.44922583
115TAOK30.44272359
116PLK10.43179117
117PRKAA20.42830255
118WNK40.42341514
119STK110.42159772
120PRKCE0.41825537
121CSNK1A1L0.41187309
122MAP2K10.40781240
123AURKA0.40587396
124TRPM70.40571286
125CAMK10.40498158
126CAMKK20.39633117
127RAF10.39530941
128MAP2K60.39176018
129CAMK2G0.38959038
130GRK70.38673674
131TAF10.38542898
132FGFR20.37794403
133FLT30.37701858
134CSNK1G10.37281455
135CHUK0.37206702
136CHEK20.36700944
137CSNK1A10.35393067
138OBSCN0.34951572
139NLK0.34869190
140MARK30.34857779
141PRKACA0.34597536
142PRKAA10.34586039
143ERBB20.34215287
144SYK0.34194091
145GRK10.34020276
146JAK30.33854245
147MAP3K130.33811067
148WEE10.33739532
149ATR0.33450243
150MELK0.33235621
151ZAK0.32375671
152ERBB30.32086472
153RPS6KA60.31266544
154CAMK1G0.30398132
155CAMK2D0.30043631
156CSNK1D0.29125831
157PRKCA0.28435217
158BCKDK0.28184538
159ITK0.27663134
160FER0.27617992

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007503.76853038
2Collecting duct acid secretion_Homo sapiens_hsa049663.42703580
3Proteasome_Homo sapiens_hsa030503.26291136
4Basal transcription factors_Homo sapiens_hsa030222.98798305
5Nitrogen metabolism_Homo sapiens_hsa009102.96353385
6Synaptic vesicle cycle_Homo sapiens_hsa047212.90770199
7RNA polymerase_Homo sapiens_hsa030202.65013526
8Oxidative phosphorylation_Homo sapiens_hsa001902.50542883
9Butanoate metabolism_Homo sapiens_hsa006502.42947804
10Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.36521631
11Selenocompound metabolism_Homo sapiens_hsa004502.21133251
12Tryptophan metabolism_Homo sapiens_hsa003802.06106963
13Nicotine addiction_Homo sapiens_hsa050332.03278618
14Vibrio cholerae infection_Homo sapiens_hsa051102.01108466
15Regulation of autophagy_Homo sapiens_hsa041401.97528985
16Olfactory transduction_Homo sapiens_hsa047401.95619941
17Amphetamine addiction_Homo sapiens_hsa050311.95293354
18Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.92621433
19Phototransduction_Homo sapiens_hsa047441.85805208
20Protein export_Homo sapiens_hsa030601.80979570
21Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.79701600
22Parkinsons disease_Homo sapiens_hsa050121.66373939
23SNARE interactions in vesicular transport_Homo sapiens_hsa041301.65261930
24Purine metabolism_Homo sapiens_hsa002301.62644000
25Maturity onset diabetes of the young_Homo sapiens_hsa049501.60877283
26Huntingtons disease_Homo sapiens_hsa050161.60394746
27Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.53216366
28Fatty acid elongation_Homo sapiens_hsa000621.49578747
29Sphingolipid metabolism_Homo sapiens_hsa006001.48751647
30Oocyte meiosis_Homo sapiens_hsa041141.48010517
31ABC transporters_Homo sapiens_hsa020101.47983212
32Caffeine metabolism_Homo sapiens_hsa002321.46973176
33Ether lipid metabolism_Homo sapiens_hsa005651.46648632
34One carbon pool by folate_Homo sapiens_hsa006701.45186465
35Linoleic acid metabolism_Homo sapiens_hsa005911.43812477
36Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.43477936
37Glycerophospholipid metabolism_Homo sapiens_hsa005641.39454693
38Intestinal immune network for IgA production_Homo sapiens_hsa046721.39066666
39Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.37157952
40Long-term potentiation_Homo sapiens_hsa047201.33606443
41Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.30565966
42Alzheimers disease_Homo sapiens_hsa050101.28888522
43alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.26935984
44Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.24414158
45Pyruvate metabolism_Homo sapiens_hsa006201.23637552
46Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.23252183
47Circadian entrainment_Homo sapiens_hsa047131.22552307
48Nucleotide excision repair_Homo sapiens_hsa034201.21585005
49Peroxisome_Homo sapiens_hsa041461.16889711
50Glutamatergic synapse_Homo sapiens_hsa047241.16428595
51Serotonergic synapse_Homo sapiens_hsa047261.16163538
52Rheumatoid arthritis_Homo sapiens_hsa053231.15768356
53Steroid hormone biosynthesis_Homo sapiens_hsa001401.14814357
54Pyrimidine metabolism_Homo sapiens_hsa002401.14341223
55Morphine addiction_Homo sapiens_hsa050321.14250635
56Cell cycle_Homo sapiens_hsa041101.13887682
57RNA degradation_Homo sapiens_hsa030181.13255623
58Insulin secretion_Homo sapiens_hsa049111.13034376
59Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.12782132
60Primary bile acid biosynthesis_Homo sapiens_hsa001201.09491316
61Chemical carcinogenesis_Homo sapiens_hsa052041.08788708
62Dopaminergic synapse_Homo sapiens_hsa047281.07333523
63RNA transport_Homo sapiens_hsa030131.06668913
64Glycerolipid metabolism_Homo sapiens_hsa005611.06515518
65Cysteine and methionine metabolism_Homo sapiens_hsa002701.05921337
66Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.04260929
67Taste transduction_Homo sapiens_hsa047421.03139826
68Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.97776376
69Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.96219163
70beta-Alanine metabolism_Homo sapiens_hsa004100.94438101
71GABAergic synapse_Homo sapiens_hsa047270.92383596
72Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.87096614
73Cocaine addiction_Homo sapiens_hsa050300.85183053
74Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.82974684
75Histidine metabolism_Homo sapiens_hsa003400.82826030
76Salivary secretion_Homo sapiens_hsa049700.82310797
77Retinol metabolism_Homo sapiens_hsa008300.81381846
78Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.81131398
79Dorso-ventral axis formation_Homo sapiens_hsa043200.80827469
80Cardiac muscle contraction_Homo sapiens_hsa042600.79688346
81Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.78686856
82Steroid biosynthesis_Homo sapiens_hsa001000.75182987
83Phagosome_Homo sapiens_hsa041450.72966165
84Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.72400318
85Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.71278149
86Fructose and mannose metabolism_Homo sapiens_hsa000510.68670350
87Circadian rhythm_Homo sapiens_hsa047100.68234009
88Vascular smooth muscle contraction_Homo sapiens_hsa042700.65788020
89Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.65541124
90Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.65468418
91Ovarian steroidogenesis_Homo sapiens_hsa049130.65200394
92Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.64769943
93Asthma_Homo sapiens_hsa053100.64454160
94Metabolic pathways_Homo sapiens_hsa011000.63038527
95Fat digestion and absorption_Homo sapiens_hsa049750.62954434
96Fanconi anemia pathway_Homo sapiens_hsa034600.62763193
97Primary immunodeficiency_Homo sapiens_hsa053400.62340278
98Arachidonic acid metabolism_Homo sapiens_hsa005900.60454056
99Calcium signaling pathway_Homo sapiens_hsa040200.58715534
100Long-term depression_Homo sapiens_hsa047300.58285439
101Propanoate metabolism_Homo sapiens_hsa006400.56180396
102Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.55844769
103Base excision repair_Homo sapiens_hsa034100.55508550
104Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.52881620
105Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.51166736
106Cholinergic synapse_Homo sapiens_hsa047250.49622443
107Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.47969590
108Renin secretion_Homo sapiens_hsa049240.47389405
109Pentose phosphate pathway_Homo sapiens_hsa000300.46560776
110Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.46183355
111Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.45149988
112Homologous recombination_Homo sapiens_hsa034400.44043111
113Non-homologous end-joining_Homo sapiens_hsa034500.43319406
114Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.43200417
115Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.42873043
116Glucagon signaling pathway_Homo sapiens_hsa049220.42082208
117Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.41652107
118Lysine degradation_Homo sapiens_hsa003100.41487682
119Gastric acid secretion_Homo sapiens_hsa049710.41452806
120Phosphatidylinositol signaling system_Homo sapiens_hsa040700.41056118
121Oxytocin signaling pathway_Homo sapiens_hsa049210.40934949
122Fatty acid biosynthesis_Homo sapiens_hsa000610.40295325
123cAMP signaling pathway_Homo sapiens_hsa040240.40248443
124Pentose and glucuronate interconversions_Homo sapiens_hsa000400.37366713
125Sulfur relay system_Homo sapiens_hsa041220.37242084
126Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.36048064
127Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.35575059
128Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.35529228
129Sulfur metabolism_Homo sapiens_hsa009200.34603637
130cGMP-PKG signaling pathway_Homo sapiens_hsa040220.34407849
131Aldosterone synthesis and secretion_Homo sapiens_hsa049250.34375341
132Epstein-Barr virus infection_Homo sapiens_hsa051690.34322858
133Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.34020255
134Vitamin digestion and absorption_Homo sapiens_hsa049770.33598442
135Biosynthesis of amino acids_Homo sapiens_hsa012300.33056294
136Mineral absorption_Homo sapiens_hsa049780.33016060
137p53 signaling pathway_Homo sapiens_hsa041150.32443938
138Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.31396962
139Hedgehog signaling pathway_Homo sapiens_hsa043400.31364591
140Fatty acid degradation_Homo sapiens_hsa000710.30680537
141Graft-versus-host disease_Homo sapiens_hsa053320.30377919

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