LRRC58

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)6.22566366
2nuclear pore organization (GO:0006999)5.91680738
3mitotic sister chromatid cohesion (GO:0007064)5.58207979
4regulation of centriole replication (GO:0046599)4.70574053
5pore complex assembly (GO:0046931)4.60446015
6metanephric mesenchyme development (GO:0072075)4.18646296
7ganglion development (GO:0061548)4.07868582
8DNA unwinding involved in DNA replication (GO:0006268)4.06485816
9regulation of centrosome cycle (GO:0046605)3.96967264
10glomerulus development (GO:0032835)3.93695623
11regulation of DNA endoreduplication (GO:0032875)3.91601775
12sister chromatid segregation (GO:0000819)3.87472623
13kidney mesenchyme development (GO:0072074)3.86454586
14mitotic chromosome condensation (GO:0007076)3.83256743
15regulation of centrosome duplication (GO:0010824)3.83014373
16cytoplasmic mRNA processing body assembly (GO:0033962)3.82670184
17replication fork processing (GO:0031297)3.75679865
18ribosome assembly (GO:0042255)3.73835175
19histone H2B ubiquitination (GO:0033523)3.67655419
20folic acid-containing compound biosynthetic process (GO:0009396)3.66584863
21mitotic sister chromatid segregation (GO:0000070)3.60102614
22neural crest cell development (GO:0014032)3.59179805
23retina vasculature morphogenesis in camera-type eye (GO:0061299)3.58488856
24DNA topological change (GO:0006265)3.52024891
25DNA strand elongation involved in DNA replication (GO:0006271)3.51626711
26chondrocyte proliferation (GO:0035988)3.49790503
27meiotic chromosome segregation (GO:0045132)3.48337791
28negative regulation of keratinocyte proliferation (GO:0010839)3.45945935
29somatic diversification of immune receptors via somatic mutation (GO:0002566)3.44400975
30somatic hypermutation of immunoglobulin genes (GO:0016446)3.44400975
31negative regulation of stem cell proliferation (GO:2000647)3.44003136
32DNA strand elongation (GO:0022616)3.42550384
33regulation of sister chromatid cohesion (GO:0007063)3.39674686
34regulation of glomerulus development (GO:0090192)3.39129022
35mesenchymal cell development (GO:0014031)3.37084023
36definitive hemopoiesis (GO:0060216)3.36999512
37lymph vessel development (GO:0001945)3.35531956
38sequestering of extracellular ligand from receptor (GO:0035581)3.31089910
39regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.30849836
40dermatan sulfate biosynthetic process (GO:0030208)3.29732535
41protein localization to chromosome, centromeric region (GO:0071459)3.29226078
42translesion synthesis (GO:0019985)3.28336156
43artery development (GO:0060840)3.27924464
44histone-serine phosphorylation (GO:0035404)3.26787846
45microtubule cytoskeleton organization involved in mitosis (GO:1902850)3.25952187
46regulation of translational fidelity (GO:0006450)3.25460256
47somite development (GO:0061053)3.25032745
48replicative senescence (GO:0090399)3.21622735
49mitotic nuclear envelope disassembly (GO:0007077)3.21337140
50regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.21218542
51sister chromatid cohesion (GO:0007062)3.21137886
52cell proliferation involved in kidney development (GO:0072111)3.21087140
53dermatan sulfate metabolic process (GO:0030205)3.18805020
54mesenchyme morphogenesis (GO:0072132)3.16047324
55maturation of 5.8S rRNA (GO:0000460)3.13350281
56CENP-A containing nucleosome assembly (GO:0034080)3.12952336
57spindle assembly involved in mitosis (GO:0090307)3.12448913
58mesenchymal-epithelial cell signaling (GO:0060638)3.11033046
59DNA replication initiation (GO:0006270)3.10723042
60protein K6-linked ubiquitination (GO:0085020)3.09225089
61maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.09154752
62rRNA catabolic process (GO:0016075)3.09036724
63telomere maintenance via semi-conservative replication (GO:0032201)3.08656927
64DNA duplex unwinding (GO:0032508)3.08522548
65DNA geometric change (GO:0032392)3.08440307
66embryonic camera-type eye morphogenesis (GO:0048596)3.05319058
67sympathetic nervous system development (GO:0048485)3.04977763
68non-recombinational repair (GO:0000726)3.03915966
69double-strand break repair via nonhomologous end joining (GO:0006303)3.03915966
70ribosome biogenesis (GO:0042254)3.03706711
71chromatin remodeling at centromere (GO:0031055)3.01551696
72myoblast migration (GO:0051451)3.01534523
73signal peptide processing (GO:0006465)2.99851155
74DNA replication checkpoint (GO:0000076)2.99440085
75metanephros development (GO:0001656)2.99097721
76mesenchymal cell differentiation involved in renal system development (GO:2001012)2.99051495
77mesenchymal cell differentiation involved in kidney development (GO:0072161)2.99051495
78mesenchymal cell differentiation (GO:0048762)2.96450637
79endocardial cushion morphogenesis (GO:0003203)2.96144464
80ER overload response (GO:0006983)2.95872412
81kinetochore organization (GO:0051383)2.95789145
82positive regulation of histone H3-K4 methylation (GO:0051571)2.95091167
83regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.94611902
84collagen fibril organization (GO:0030199)2.93844911
85somatic recombination of immunoglobulin gene segments (GO:0016447)2.92682060
86limb development (GO:0060173)2.92005086
87appendage development (GO:0048736)2.92005086
88morphogenesis of an epithelial sheet (GO:0002011)2.91975021
89smooth muscle tissue development (GO:0048745)2.91458389
90negative regulation of JUN kinase activity (GO:0043508)2.91112970
91membrane disassembly (GO:0030397)2.90533910
92nuclear envelope disassembly (GO:0051081)2.90533910
93phagocytosis, engulfment (GO:0006911)2.89855969
94cerebral cortex radially oriented cell migration (GO:0021799)2.88990607
95telomere maintenance via recombination (GO:0000722)2.88864541
96negative regulation of phagocytosis (GO:0050765)2.88294297
97limb bud formation (GO:0060174)2.88132097
98mitotic recombination (GO:0006312)2.87726593
99positive regulation of mitotic sister chromatid separation (GO:1901970)2.87408587
100positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.87408587
101positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.87408587
102protein localization to kinetochore (GO:0034501)2.86197080
103cell differentiation involved in metanephros development (GO:0072202)2.85973142
104positive regulation of male gonad development (GO:2000020)2.83658803
105folic acid metabolic process (GO:0046655)2.82737574
106stem cell development (GO:0048864)2.80529998
107chondrocyte development (GO:0002063)2.80041657
108neural tube formation (GO:0001841)2.77325458
109cell differentiation involved in kidney development (GO:0061005)2.76923328
110protein heterotrimerization (GO:0070208)2.75731840
111response to BMP (GO:0071772)2.75345810
112cellular response to BMP stimulus (GO:0071773)2.75345810
113somatic diversification of immunoglobulins (GO:0016445)2.75320509
114regulation of RNA export from nucleus (GO:0046831)2.75036689
115lymphangiogenesis (GO:0001946)2.74307649
116glomerular basement membrane development (GO:0032836)2.74301811
117positive regulation of glomerulus development (GO:0090193)2.74282202
118extracellular negative regulation of signal transduction (GO:1900116)2.74277189
119extracellular regulation of signal transduction (GO:1900115)2.74277189
120postreplication repair (GO:0006301)2.74153258
121nucleobase biosynthetic process (GO:0046112)2.73274730
122regulation of non-canonical Wnt signaling pathway (GO:2000050)2.72808935
123spindle assembly (GO:0051225)2.72636034
124kidney morphogenesis (GO:0060993)2.72226471
125negative regulation of DNA-dependent DNA replication (GO:2000104)2.72133169
126nucleotide-excision repair, DNA gap filling (GO:0006297)2.70345117
127regulation of mRNA 3-end processing (GO:0031440)2.69935699
128embryonic digit morphogenesis (GO:0042733)2.69810681
129biotin metabolic process (GO:0006768)2.68804026
130facial nerve structural organization (GO:0021612)2.68741637
131negative regulation of glycogen biosynthetic process (GO:0045719)2.68588424
132dosage compensation (GO:0007549)2.68024186
133regulation of pigment cell differentiation (GO:0050932)2.67368350
134cranial suture morphogenesis (GO:0060363)2.67247372
135mesonephros development (GO:0001823)2.67090931
136regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.66784188
137mitochondrial RNA metabolic process (GO:0000959)2.66712623
138negative regulation of dendrite morphogenesis (GO:0050774)2.66385451
139positive regulation of chromosome segregation (GO:0051984)2.66349549
140regulation of male gonad development (GO:2000018)2.66336986
141DNA conformation change (GO:0071103)2.66211764
142regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.65186928
143negative regulation of chondrocyte differentiation (GO:0032331)2.65051554
144positive regulation of mRNA 3-end processing (GO:0031442)2.65035908
145outer ear morphogenesis (GO:0042473)2.64222770
146radial glial cell differentiation (GO:0060019)2.64086602
147positive regulation of smooth muscle cell migration (GO:0014911)2.64016576
148nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.63891200
149folic acid-containing compound metabolic process (GO:0006760)2.63730004
150anatomical structure arrangement (GO:0048532)2.63379692
151branching involved in ureteric bud morphogenesis (GO:0001658)2.63314737
152regulation of translational elongation (GO:0006448)2.62797788
153cardiac epithelial to mesenchymal transition (GO:0060317)2.61979105
154atrial septum morphogenesis (GO:0060413)2.60842244
155negative regulation of systemic arterial blood pressure (GO:0003085)2.59606422
156mitotic spindle organization (GO:0007052)2.58895138
157regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.57564760
158regulation of mesenchymal cell proliferation (GO:0010464)2.57085649
159protein localization to chromosome (GO:0034502)2.56973764
160regulation of DNA-dependent DNA replication (GO:0090329)2.56530286
161chromosome segregation (GO:0007059)2.56456067
162axon extension involved in axon guidance (GO:0048846)2.56063121
163neuron projection extension involved in neuron projection guidance (GO:1902284)2.56063121
164Notch signaling involved in heart development (GO:0061314)2.56028542
165somatic cell DNA recombination (GO:0016444)2.55960333
166somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.55960333
167positive regulation of branching involved in ureteric bud morphogenesis (GO:0090190)2.55359764
168regulation of glycogen (starch) synthase activity (GO:2000465)2.55066687
169pteridine-containing compound biosynthetic process (GO:0042559)2.54834632
170pre-miRNA processing (GO:0031054)2.54493934
171monoubiquitinated protein deubiquitination (GO:0035520)2.54146032
172negative regulation of cartilage development (GO:0061037)2.53468215
173tetrahydrofolate metabolic process (GO:0046653)2.53324545
174heart valve morphogenesis (GO:0003179)2.53012490
175regulation of branching involved in ureteric bud morphogenesis (GO:0090189)2.52489354
176protein localization to microtubule cytoskeleton (GO:0072698)2.52450110
177epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.52022929
178histone exchange (GO:0043486)2.51288127
179peripheral nervous system axon ensheathment (GO:0032292)2.51165429
180myelination in peripheral nervous system (GO:0022011)2.51165429
181phagocytosis, recognition (GO:0006910)2.50343009
182positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)2.50254772
183mammary gland development (GO:0030879)2.49802405
184negative regulation of neurotransmitter secretion (GO:0046929)2.49784697
185DNA-dependent DNA replication (GO:0006261)2.49734402
186somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.49114365
187isotype switching (GO:0045190)2.49114365
188somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.49114365
189regulation of translational termination (GO:0006449)2.49083899
190metaphase plate congression (GO:0051310)2.48373471
191pattern specification involved in kidney development (GO:0061004)2.48109456
192double-strand break repair via homologous recombination (GO:0000724)2.47755235
193DNA ligation (GO:0006266)2.47720602
194ureteric bud development (GO:0001657)2.46566234
195cell proliferation involved in metanephros development (GO:0072203)2.46194152
196mesonephric epithelium development (GO:0072163)2.44963474
197mesonephric tubule development (GO:0072164)2.43890238
198negative regulation of fatty acid transport (GO:2000192)2.43367692
199embryonic retina morphogenesis in camera-type eye (GO:0060059)2.41707777

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.60082894
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.11956018
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.05335808
4FOXM1_23109430_ChIP-Seq_U2OS_Human4.04136650
5RBPJ_22232070_ChIP-Seq_NCS_Mouse3.92710033
6CEBPD_23245923_ChIP-Seq_MEFs_Mouse3.50472330
7KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.19135987
8AR_21909140_ChIP-Seq_LNCAP_Human3.18603304
9MYC_18555785_ChIP-Seq_MESCs_Mouse2.99513515
10SMAD_19615063_ChIP-ChIP_OVARY_Human2.83860915
11TRIM28_21343339_ChIP-Seq_HEK293_Human2.83574489
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.79197050
13E2F1_21310950_ChIP-Seq_MCF-7_Human2.68371475
14POU3F2_20337985_ChIP-ChIP_501MEL_Human2.63632083
15WT1_19549856_ChIP-ChIP_CCG9911_Human2.56907356
16GBX2_23144817_ChIP-Seq_PC3_Human2.53940919
17KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.49619787
18PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.45892388
19FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.37899579
20GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.37832005
21PADI4_21655091_ChIP-ChIP_MCF-7_Human2.33022455
22CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.32444120
23SALL1_21062744_ChIP-ChIP_HESCs_Human2.30084448
24FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.25204725
25MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.22855313
26NFE2L2_20460467_ChIP-Seq_MEFs_Mouse2.12546928
27NRF2_20460467_ChIP-Seq_MEFs_Mouse2.12546928
28OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.00339721
29POU5F1_16153702_ChIP-ChIP_HESCs_Human1.98339321
30PIAS1_25552417_ChIP-Seq_VCAP_Human1.97143980
31SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.95779827
32P300_19829295_ChIP-Seq_ESCs_Human1.93460917
33CDX2_19796622_ChIP-Seq_MESCs_Mouse1.91684812
34* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.90903855
35ZNF217_24962896_ChIP-Seq_MCF-7_Human1.90646543
36YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.90210069
37FUS_26573619_Chip-Seq_HEK293_Human1.87214067
38PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.86145320
39ZFP57_27257070_Chip-Seq_ESCs_Mouse1.86093907
40MYC_19030024_ChIP-ChIP_MESCs_Mouse1.86030134
41ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.85546368
42* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.85388151
43GABP_17652178_ChIP-ChIP_JURKAT_Human1.85208521
44CJUN_26792858_Chip-Seq_BT549_Human1.82399487
45AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.79954648
46NOTCH1_21737748_ChIP-Seq_TLL_Human1.78143307
47DCP1A_22483619_ChIP-Seq_HELA_Human1.76689287
48FLI1_27457419_Chip-Seq_LIVER_Mouse1.75366211
49EWS_26573619_Chip-Seq_HEK293_Human1.73363106
50SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.72090850
51EST1_17652178_ChIP-ChIP_JURKAT_Human1.70059106
52TP53_18474530_ChIP-ChIP_U2OS_Human1.69275267
53EP300_21415370_ChIP-Seq_HL-1_Mouse1.68998269
54KDM5A_27292631_Chip-Seq_BREAST_Human1.66537307
55VDR_23849224_ChIP-Seq_CD4+_Human1.65907540
56TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.65830142
57CREB1_15753290_ChIP-ChIP_HEK293T_Human1.65800905
58AR_21572438_ChIP-Seq_LNCaP_Human1.65466221
59NELFA_20434984_ChIP-Seq_ESCs_Mouse1.59495473
60ER_23166858_ChIP-Seq_MCF-7_Human1.58290995
61MYC_19079543_ChIP-ChIP_MESCs_Mouse1.55116319
62TTF2_22483619_ChIP-Seq_HELA_Human1.54998051
63ETS1_20019798_ChIP-Seq_JURKAT_Human1.54688989
64SMAD4_21799915_ChIP-Seq_A2780_Human1.52700581
65IGF1R_20145208_ChIP-Seq_DFB_Human1.49704217
66PCGF2_27294783_Chip-Seq_ESCs_Mouse1.49140460
67MYC_18940864_ChIP-ChIP_HL60_Human1.48385981
68BRD4_25478319_ChIP-Seq_HGPS_Human1.47926069
69RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.47162148
70TAF15_26573619_Chip-Seq_HEK293_Human1.44527403
71SALL4_18804426_ChIP-ChIP_XEN_Mouse1.44018770
72ZFX_18555785_ChIP-Seq_MESCs_Mouse1.43812569
73GATA2_21666600_ChIP-Seq_HMVEC_Human1.43076939
74HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.42416665
75PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.41567167
76TOP2B_26459242_ChIP-Seq_MCF-7_Human1.41545275
77MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.41335660
78EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.41327757
79TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.41238606
80E2F1_18555785_Chip-Seq_ESCs_Mouse1.39299267
81CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.38628142
82NANOG_18555785_Chip-Seq_ESCs_Mouse1.38522554
83MYC_18358816_ChIP-ChIP_MESCs_Mouse1.38449368
84NR3C1_21868756_ChIP-Seq_MCF10A_Human1.37428619
85JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.37319634
86* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.35068031
87XRN2_22483619_ChIP-Seq_HELA_Human1.33794791
88GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33516816
89HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.32959970
90FOXP3_21729870_ChIP-Seq_TREG_Human1.31532103
91EED_16625203_ChIP-ChIP_MESCs_Mouse1.30523725
92E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.30475228
93CHD1_26751641_Chip-Seq_LNCaP_Human1.30351194
94SMAD3_21741376_ChIP-Seq_EPCs_Human1.30231231
95TP63_19390658_ChIP-ChIP_HaCaT_Human1.29724091
96TCF4_18268006_ChIP-ChIP_LS174T_Human1.28703047
97SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.26402495
98SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.26084649
99* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.24789303
100STAT3_23295773_ChIP-Seq_U87_Human1.24037702
101AHR_22903824_ChIP-Seq_MCF-7_Human1.23151816
102P53_22387025_ChIP-Seq_ESCs_Mouse1.23118188
103SUZ12_18555785_Chip-Seq_ESCs_Mouse1.22621632
104ESR1_20079471_ChIP-ChIP_T-47D_Human1.22137930
105CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.21245220
106SUZ12_27294783_Chip-Seq_NPCs_Mouse1.19853023
107TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.19841918
108CBX2_27304074_Chip-Seq_ESCs_Mouse1.18909832
109ARNT_22903824_ChIP-Seq_MCF-7_Human1.18654593
110FOXM1_26456572_ChIP-Seq_MCF-7_Human1.18477073
111CMYC_18555785_Chip-Seq_ESCs_Mouse1.18307698
112SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.17920174
113EZH2_27294783_Chip-Seq_NPCs_Mouse1.17884425
114Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.16912823
115UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.16893894
116RXR_22108803_ChIP-Seq_LS180_Human1.16077227
117PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.16050343
118CTBP2_25329375_ChIP-Seq_LNCAP_Human1.15957664
119STAT3_18555785_Chip-Seq_ESCs_Mouse1.15695178
120POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.15586855
121VDR_22108803_ChIP-Seq_LS180_Human1.14520603
122SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.14380812
123SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.14380812
124* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.13191181
125PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.13007212
126P300_18555785_Chip-Seq_ESCs_Mouse1.12899469
127* TFEB_21752829_ChIP-Seq_HELA_Human1.11791736
128SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.11549434
129VDR_24787735_ChIP-Seq_THP-1_Human1.11517467
130* GABP_19822575_ChIP-Seq_HepG2_Human1.10272606
131* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.09569573
132ZNF274_21170338_ChIP-Seq_K562_Hela1.09292018
133TP53_16413492_ChIP-PET_HCT116_Human1.08688543
134AR_25329375_ChIP-Seq_VCAP_Human1.08123089
135PKCTHETA_26484144_Chip-Seq_BREAST_Human1.07277006
136FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.07184923
137SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.06832405
138ERG_20887958_ChIP-Seq_HPC-7_Mouse1.06795444
139RUNX2_22187159_ChIP-Seq_PCA_Human1.06505957
140JUN_21703547_ChIP-Seq_K562_Human1.06267902
141PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.06201095
142EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.06149614
143ELF1_17652178_ChIP-ChIP_JURKAT_Human1.06070273
144CLOCK_20551151_ChIP-Seq_293T_Human1.05932087
145ELK1_19687146_ChIP-ChIP_HELA_Human1.05878435
146PCGF2_27294783_Chip-Seq_NPCs_Mouse1.05826946
147CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.05051582
148* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.05010000
149SOX2_18555785_Chip-Seq_ESCs_Mouse1.03949649
150NFE2_27457419_Chip-Seq_LIVER_Mouse1.03150255
151NMYC_18555785_Chip-Seq_ESCs_Mouse1.02762535
152HOXB4_20404135_ChIP-ChIP_EML_Mouse1.02245640
153FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.98436814
154FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.97297111
155ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.93089639
156CIITA_25753668_ChIP-Seq_RAJI_Human0.92202540
157THAP11_20581084_ChIP-Seq_MESCs_Mouse0.92084493
158MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.90927542
159ESR1_15608294_ChIP-ChIP_MCF-7_Human0.90786273
160SOX17_20123909_ChIP-Seq_XEN_Mouse0.90285699
161CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.88225182
162IRF1_19129219_ChIP-ChIP_H3396_Human0.86270116
163EGR1_19374776_ChIP-ChIP_THP-1_Human0.83204544
164SRF_21415370_ChIP-Seq_HL-1_Mouse0.81578123
165CBP_20019798_ChIP-Seq_JUKART_Human0.79708252
166IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.79708252
167ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.76732597
168POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.76328527
169EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.73315007
170* TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.73303991

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.10386068
2MP0008438_abnormal_cutaneous_collagen4.31893623
3MP0010094_abnormal_chromosome_stability4.20035342
4MP0005503_abnormal_tendon_morphology3.85568964
5MP0005171_absent_coat_pigmentation3.49852002
6MP0002009_preneoplasia3.01346055
7MP0004272_abnormal_basement_membrane2.98822421
8MP0003111_abnormal_nucleus_morphology2.95598562
9MP0008058_abnormal_DNA_repair2.71118581
10MP0001879_abnormal_lymphatic_vessel2.60999152
11MP0003077_abnormal_cell_cycle2.59160968
12MP0000566_synostosis2.52992670
13MP0003693_abnormal_embryo_hatching2.33464487
14MP0009250_abnormal_appendicular_skeleto2.30181935
15MP0010368_abnormal_lymphatic_system2.28930546
16MP0005275_abnormal_skin_tensile2.28131669
17MP0010352_gastrointestinal_tract_polyps2.25880811
18MP0004957_abnormal_blastocyst_morpholog2.24926568
19MP0009697_abnormal_copulation2.20682584
20MP0008007_abnormal_cellular_replicative2.20273736
21MP0003279_aneurysm2.13756927
22MP0010234_abnormal_vibrissa_follicle2.07790117
23MP0002876_abnormal_thyroid_physiology2.04966787
24MP0001188_hyperpigmentation2.04146303
25MP0002877_abnormal_melanocyte_morpholog1.95952223
26MP0003941_abnormal_skin_development1.91351793
27MP0003385_abnormal_body_wall1.89987532
28MP0005248_abnormal_Harderian_gland1.88811021
29MP0010030_abnormal_orbit_morphology1.87312960
30MP0003942_abnormal_urinary_system1.87311493
31MP0009384_cardiac_valve_regurgitation1.86371802
32MP0005367_renal/urinary_system_phenotyp1.85778014
33MP0000516_abnormal_urinary_system1.85778014
34MP0010307_abnormal_tumor_latency1.82922407
35MP0010678_abnormal_skin_adnexa1.81488211
36MP0005409_darkened_coat_color1.81318889
37MP0001177_atelectasis1.77169377
38MP0004134_abnormal_chest_morphology1.75438790
39MP0003950_abnormal_plasma_membrane1.72618988
40MP0009053_abnormal_anal_canal1.71591087
41MP0000372_irregular_coat_pigmentation1.70375150
42MP0003890_abnormal_embryonic-extraembry1.69994781
43MP0000383_abnormal_hair_follicle1.69146843
44MP0005508_abnormal_skeleton_morphology1.68735374
45MP0002938_white_spotting1.61989341
46MP0005187_abnormal_penis_morphology1.60756140
47MP0003943_abnormal_hepatobiliary_system1.58373743
48MP0008932_abnormal_embryonic_tissue1.58051609
49MP0009780_abnormal_chondrocyte_physiolo1.57488531
50MP0002396_abnormal_hematopoietic_system1.57352032
51MP0005408_hypopigmentation1.57057866
52MP0005174_abnormal_tail_pigmentation1.56391061
53MP0000015_abnormal_ear_pigmentation1.56086398
54MP0006054_spinal_hemorrhage1.55561891
55MP0003122_maternal_imprinting1.55320059
56MP0001299_abnormal_eye_distance/1.55139877
57MP0002160_abnormal_reproductive_system1.51113646
58MP0000049_abnormal_middle_ear1.49569909
59MP0002108_abnormal_muscle_morphology1.45343845
60MP0000350_abnormal_cell_proliferation1.45173144
61MP0004808_abnormal_hematopoietic_stem1.41926613
62MP0001958_emphysema1.41692031
63MP0005646_abnormal_pituitary_gland1.41396780
64MP0003136_yellow_coat_color1.40367649
65MP0003937_abnormal_limbs/digits/tail_de1.40063769
66MP0003786_premature_aging1.39538593
67MP0003755_abnormal_palate_morphology1.37587599
68MP0003315_abnormal_perineum_morphology1.37451989
69MP0000647_abnormal_sebaceous_gland1.36958234
70MP0002177_abnormal_outer_ear1.36219811
71MP0004185_abnormal_adipocyte_glucose1.35871636
72MP0009379_abnormal_foot_pigmentation1.34637615
73MP0000163_abnormal_cartilage_morphology1.28220055
74MP0005076_abnormal_cell_differentiation1.24477871
75MP0000371_diluted_coat_color1.24008960
76MP0002075_abnormal_coat/hair_pigmentati1.23428253
77MP0002282_abnormal_trachea_morphology1.22755957
78MP0002115_abnormal_skeleton_extremities1.22450418
79MP0006072_abnormal_retinal_apoptosis1.20852032
80MP0001697_abnormal_embryo_size1.20157327
81MP0002084_abnormal_developmental_patter1.19871462
82MP0001672_abnormal_embryogenesis/_devel1.18241445
83MP0005380_embryogenesis_phenotype1.18241445
84MP0005389_reproductive_system_phenotype1.16689335
85MP0002249_abnormal_larynx_morphology1.15460555
86MP0000767_abnormal_smooth_muscle1.15377349
87MP0003984_embryonic_growth_retardation1.15198822
88MP0002088_abnormal_embryonic_growth/wei1.15162983
89MP0004233_abnormal_muscle_weight1.13991558
90MP0002109_abnormal_limb_morphology1.13980620
91MP0004197_abnormal_fetal_growth/weight/1.12533711
92MP0002098_abnormal_vibrissa_morphology1.12052789
93MP0000537_abnormal_urethra_morphology1.10934039
94MP0005388_respiratory_system_phenotype1.10775982
95MP0002133_abnormal_respiratory_system1.10775982
96MP0000534_abnormal_ureter_morphology1.09335338
97MP0000681_abnormal_thyroid_gland1.08753312
98MP0003828_pulmonary_edema1.08675375
99MP0003935_abnormal_craniofacial_develop1.07725921
100MP0003121_genomic_imprinting1.07311672
101MP0003787_abnormal_imprinting1.06982663
102MP0002163_abnormal_gland_morphology1.06822170
103MP0000627_abnormal_mammary_gland1.06559028
104MP0000432_abnormal_head_morphology1.05800368
105MP0005623_abnormal_meninges_morphology1.05112752
106MP0003115_abnormal_respiratory_system1.03159380
107MP0002896_abnormal_bone_mineralization1.02532425
108MP0001324_abnormal_eye_pigmentation0.99818098
109MP0000013_abnormal_adipose_tissue0.98907937
110MP0000427_abnormal_hair_cycle0.98832626
111MP0002295_abnormal_pulmonary_circulatio0.98757763
112MP0001730_embryonic_growth_arrest0.98699691
113MP0002697_abnormal_eye_size0.98660480
114MP0002116_abnormal_craniofacial_bone0.97391763
115MP0000377_abnormal_hair_follicle0.96380281
116MP0005670_abnormal_white_adipose0.95788005
117MP0001542_abnormal_bone_strength0.94856147
118MP0005379_endocrine/exocrine_gland_phen0.92577427
119MP0000678_abnormal_parathyroid_gland0.92304029
120MP0002095_abnormal_skin_pigmentation0.91980008
121MP0001286_abnormal_eye_development0.91869539
122MP0005075_abnormal_melanosome_morpholog0.90850548
123MP0002006_tumorigenesis0.90512418
124MP0000428_abnormal_craniofacial_morphol0.89980088
125MP0002086_abnormal_extraembryonic_tissu0.89800855
126MP0002085_abnormal_embryonic_tissue0.89781084
127MP0005253_abnormal_eye_physiology0.89612239
128MP0001175_abnormal_lung_morphology0.89300363
129MP0002113_abnormal_skeleton_development0.89297368
130MP0002092_abnormal_eye_morphology0.87487994
131MP0002234_abnormal_pharynx_morphology0.87369579
132MP0002080_prenatal_lethality0.87077690
133MP0005257_abnormal_intraocular_pressure0.86638241
134MP0008877_abnormal_DNA_methylation0.86597304
135MP0002060_abnormal_skin_morphology0.85762110
136MP0005595_abnormal_vascular_smooth0.85480625
137MP0001986_abnormal_taste_sensitivity0.85280673
138MP0006138_congestive_heart_failure0.84725293
139MP0001346_abnormal_lacrimal_gland0.84150362
140MP0002166_altered_tumor_susceptibility0.83751560
141MP0002233_abnormal_nose_morphology0.83285717
142MP0000358_abnormal_cell_content/0.83177007
143MP0005391_vision/eye_phenotype0.82224816
144MP0005084_abnormal_gallbladder_morpholo0.82064545
145MP0004883_abnormal_blood_vessel0.81797607
146MP0000003_abnormal_adipose_tissue0.79979934
147MP0005390_skeleton_phenotype0.79868940
148MP0001293_anophthalmia0.79603910
149MP0002128_abnormal_blood_circulation0.79512440
150MP0002928_abnormal_bile_duct0.77157317
151MP0001186_pigmentation_phenotype0.76294247
152MP0005164_abnormal_response_to0.76110606
153MP0003705_abnormal_hypodermis_morpholog0.75858796
154MP0000569_abnormal_digit_pigmentation0.75693169
155MP0003936_abnormal_reproductive_system0.75597126
156MP0002932_abnormal_joint_morphology0.75503789
157MP0001919_abnormal_reproductive_system0.75323293
158MP0001661_extended_life_span0.74480525
159MP0003959_abnormal_lean_body0.73368268
160MP0009703_decreased_birth_body0.72520903
161MP0004381_abnormal_hair_follicle0.70623931
162MP0002210_abnormal_sex_determination0.70267966
163MP0000313_abnormal_cell_death0.70116997
164MP0001929_abnormal_gametogenesis0.70084642
165MP0001881_abnormal_mammary_gland0.69065522
166MP0005220_abnormal_exocrine_pancreas0.68858870
167MP0005647_abnormal_sex_gland0.68182402
168MP0000631_abnormal_neuroendocrine_gland0.66355973
169MP0001145_abnormal_male_reproductive0.66083211
170MP0002111_abnormal_tail_morphology0.64709367
171MP0001216_abnormal_epidermal_layer0.62879220
172MP0003718_maternal_effect0.62439464

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)4.74173438
2Chromsome breakage (HP:0040012)4.72242232
3Asymmetry of the thorax (HP:0001555)4.23701167
4Spinal cord lesions (HP:0100561)4.05792298
5Syringomyelia (HP:0003396)4.05792298
6Abnormality of the nasal septum (HP:0000419)3.92731738
7Volvulus (HP:0002580)3.71749400
8Abnormality of incisor morphology (HP:0011063)3.55032874
9Abnormality of chromosome stability (HP:0003220)3.29248891
10Birth length less than 3rd percentile (HP:0003561)3.25050032
11Aplasia/Hypoplasia of the uvula (HP:0010293)2.95206226
12Abnormality of the carotid arteries (HP:0005344)2.87640395
13Hyperalaninemia (HP:0003348)2.77106767
14Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.77106767
15Abnormality of alanine metabolism (HP:0010916)2.77106767
16Abnormality of the preputium (HP:0100587)2.76003724
17Increased nuchal translucency (HP:0010880)2.74937346
18Deep philtrum (HP:0002002)2.71707525
19Premature rupture of membranes (HP:0001788)2.67496284
20Meckel diverticulum (HP:0002245)2.64711842
21Fibular hypoplasia (HP:0003038)2.62953376
22Abnormal hair whorl (HP:0010721)2.61498092
23Insidious onset (HP:0003587)2.56421497
24Termporal pattern (HP:0011008)2.56421497
25Short 4th metacarpal (HP:0010044)2.53084963
26Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.53084963
27Abnormality of the ileum (HP:0001549)2.50125185
28Hepatoblastoma (HP:0002884)2.49381951
29Partial agenesis of the corpus callosum (HP:0001338)2.47628964
30Alveolar cell carcinoma (HP:0006519)2.47166929
31Submucous cleft hard palate (HP:0000176)2.45955387
32Missing ribs (HP:0000921)2.42905801
33White forelock (HP:0002211)2.42677648
34Pheochromocytoma (HP:0002666)2.41924682
35Hypothermia (HP:0002045)2.41577550
36Clubbing of toes (HP:0100760)2.36128218
37Protrusio acetabuli (HP:0003179)2.34819666
38Overgrowth (HP:0001548)2.32685854
39Papillary thyroid carcinoma (HP:0002895)2.32618644
40Patchy hypopigmentation of hair (HP:0011365)2.27325881
41Thyroid carcinoma (HP:0002890)2.24955110
42Glioma (HP:0009733)2.24773112
43Sloping forehead (HP:0000340)2.22021620
44Spinal rigidity (HP:0003306)2.21556680
45Acute myeloid leukemia (HP:0004808)2.20088707
46Myelodysplasia (HP:0002863)2.19502622
47Bell-shaped thorax (HP:0001591)2.18624896
48Neoplasm of the adrenal cortex (HP:0100641)2.17312888
49Septate vagina (HP:0001153)2.16500163
50Neoplasm of the tracheobronchial system (HP:0100552)2.15287678
51Abnormality of the ischium (HP:0003174)2.15154176
52Small intestinal stenosis (HP:0012848)2.14228457
53Duodenal stenosis (HP:0100867)2.14228457
54Abnormality of the nasolacrimal system (HP:0000614)2.13900624
55Cafe-au-lait spot (HP:0000957)2.13095330
56Increased number of teeth (HP:0011069)2.12969361
57Heterochromia iridis (HP:0001100)2.11971903
58Cutaneous melanoma (HP:0012056)2.10707850
59Abnormality of chromosome segregation (HP:0002916)2.10231120
60Microglossia (HP:0000171)2.09792396
61Absent frontal sinuses (HP:0002688)2.09512454
62Macroorchidism (HP:0000053)2.08773418
63Rhabdomyosarcoma (HP:0002859)2.08323631
64Soft skin (HP:0000977)2.08107169
65Astrocytoma (HP:0009592)2.08062956
66Abnormality of the astrocytes (HP:0100707)2.08062956
67Pulmonary artery stenosis (HP:0004415)2.08007639
68Abnormality of the frontal sinuses (HP:0002687)2.03727063
69Medulloblastoma (HP:0002885)2.02882348
70Tubulointerstitial nephritis (HP:0001970)1.99606288
71Embryonal renal neoplasm (HP:0011794)1.99332163
72Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.98061245
73Cervical subluxation (HP:0003308)1.97947920
74Adrenal hypoplasia (HP:0000835)1.97834231
75Hypoplastic left heart (HP:0004383)1.97761899
76Aplasia involving bones of the extremities (HP:0009825)1.96845892
77Aplasia involving bones of the upper limbs (HP:0009823)1.96845892
78Aplasia of the phalanges of the hand (HP:0009802)1.96845892
79Short nail (HP:0001799)1.96641858
80Follicular hyperkeratosis (HP:0007502)1.95983043
8111 pairs of ribs (HP:0000878)1.95968264
82Flat capital femoral epiphysis (HP:0003370)1.95752200
83Absent eyebrow (HP:0002223)1.95726644
84Enlarged kidneys (HP:0000105)1.94481578
85Mesomelia (HP:0003027)1.91889233
86Midline defect of the nose (HP:0004122)1.91748326
87Neonatal hypoglycemia (HP:0001998)1.91659788
88Hematochezia (HP:0002573)1.91260267
89Wormian bones (HP:0002645)1.89678689
90Pulmonic stenosis (HP:0001642)1.88046289
91Neuroendocrine neoplasm (HP:0100634)1.87703511
92Cystic hygroma (HP:0000476)1.86942829
93Cranial hyperostosis (HP:0004437)1.86799006
94Morphological abnormality of the middle ear (HP:0008609)1.86672954
95Renovascular hypertension (HP:0100817)1.86089530
96Acute lymphatic leukemia (HP:0006721)1.85036320
97Sandal gap (HP:0001852)1.84935060
98Aortic valve stenosis (HP:0001650)1.84805604
99Vertebral compression fractures (HP:0002953)1.84763694
100Aplasia/Hypoplasia of the tibia (HP:0005772)1.84444567
101Aplasia/Hypoplasia of the fibula (HP:0006492)1.83641743
102Elfin facies (HP:0004428)1.83450460
103Renal dysplasia (HP:0000110)1.83447374
104Flared iliac wings (HP:0002869)1.83350114
105Abnormality of the phalanges of the 2nd finger (HP:0009541)1.83176768
106Mitral stenosis (HP:0001718)1.82146643
107Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.80516809
108Proximal placement of thumb (HP:0009623)1.80174590
109Prominent nose (HP:0000448)1.80024671
110Abnormality of the duodenum (HP:0002246)1.79689781
111Tracheomalacia (HP:0002779)1.79653281
112Nephroblastoma (Wilms tumor) (HP:0002667)1.78793362
113Abnormality of dentin (HP:0010299)1.78660661
114Capillary hemangiomas (HP:0005306)1.78347361
115Deviation of the thumb (HP:0009603)1.77288640
116Cerebellar dysplasia (HP:0007033)1.77136743
117Aqueductal stenosis (HP:0002410)1.77001148
118Neonatal short-limb short stature (HP:0008921)1.76940764
119Abnormality of the phalanges of the hallux (HP:0010057)1.76652119
120Craniofacial hyperostosis (HP:0004493)1.76501527
121Colon cancer (HP:0003003)1.76245476
122Aortic aneurysm (HP:0004942)1.75465834
123Wide anterior fontanel (HP:0000260)1.75184704
124Abnormality of the phalanges of the 5th finger (HP:0004213)1.74918843
125Abnormality of the lacrimal duct (HP:0011481)1.74849496
126Decreased skull ossification (HP:0004331)1.74207028
127Short thumb (HP:0009778)1.73897554
128Duplicated collecting system (HP:0000081)1.72382879
129Progressive sensorineural hearing impairment (HP:0000408)1.72258131
130Wrist flexion contracture (HP:0001239)1.71701620
131Abnormality of the incisor (HP:0000676)1.70769542
132Fair hair (HP:0002286)1.70247711
133Broad toe (HP:0001837)1.70105804
134Bradycardia (HP:0001662)1.69831277
135Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.69806615
136Degeneration of the lateral corticospinal tracts (HP:0002314)1.69806615
137Hypopigmentation of the fundus (HP:0007894)1.69319933
138Aortic dissection (HP:0002647)1.69300712
139Broad long bones (HP:0005622)1.69184027
140Abnormal auditory evoked potentials (HP:0006958)1.68767283
141Abnormality of the 4th metacarpal (HP:0010012)1.68728483
142Meningioma (HP:0002858)1.68178716
143High pitched voice (HP:0001620)1.67999868
144Neoplasm of the thyroid gland (HP:0100031)1.67396265
145Hyperacusis (HP:0010780)1.67384313
146Short tibia (HP:0005736)1.67373265
147Renal cortical cysts (HP:0000803)1.67171593
148Freckling (HP:0001480)1.67116647
149Triphalangeal thumb (HP:0001199)1.66148379
150Multiple enchondromatosis (HP:0005701)1.65196604
151Abnormality of the distal phalanx of the thumb (HP:0009617)1.65090176
152Low anterior hairline (HP:0000294)1.64729782
153Vascular tortuosity (HP:0004948)1.64710536
154Protruding tongue (HP:0010808)1.64370740
155Short middle phalanx of the 5th finger (HP:0004220)1.63712695
156Arteriovenous malformation (HP:0100026)1.63630795
157Curly hair (HP:0002212)1.63376929
158Embryonal neoplasm (HP:0002898)1.62913477
159Insulin-resistant diabetes mellitus (HP:0000831)1.62317996
160Glucose intolerance (HP:0000833)1.62204505
161Abnormality of the right ventricle (HP:0001707)1.61456714
162Coronal craniosynostosis (HP:0004440)1.61066450
163Full cheeks (HP:0000293)1.60962135
164Ectopic kidney (HP:0000086)1.60214110
165Patellar aplasia (HP:0006443)1.60209892
166Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.60088718
167Aplasia/Hypoplasia of the sternum (HP:0006714)1.60071916
168Radioulnar synostosis (HP:0002974)1.59897005
169Broad phalanx (HP:0006009)1.59606981
170Delayed cranial suture closure (HP:0000270)1.59499544
171Pancreatic cysts (HP:0001737)1.58853880
172Abnormality of the renal cortex (HP:0011035)1.57168066
173Cubitus valgus (HP:0002967)1.55700199
174Cortical dysplasia (HP:0002539)1.55494905
175Breast carcinoma (HP:0003002)1.55296787
176Choanal atresia (HP:0000453)1.53615216
177Neoplasm of the colon (HP:0100273)1.53144963
178Overriding aorta (HP:0002623)1.52904242
179Neoplasm of the peripheral nervous system (HP:0100007)1.52810685
180Ependymoma (HP:0002888)1.52095589
181Benign neoplasm of the central nervous system (HP:0100835)1.50654721
182Insomnia (HP:0100785)1.50653966
183Aplasia/Hypoplasia of the patella (HP:0006498)1.50285480

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.04024359
2CASK3.86115733
3ZAK3.30747402
4WEE12.81760373
5EEF2K2.81227532
6SCYL22.79907557
7NUAK12.66514847
8SGK22.64756323
9ERBB32.56786400
10TSSK62.56038024
11PNCK2.51945961
12AKT32.44203220
13LATS12.43599573
14CDC72.43105311
15TAF12.40399244
16BMPR1B2.35355807
17NEK92.30627684
18MKNK22.18979825
19WNK42.12232450
20MKNK12.10494082
21PRPF4B2.00607825
22MAP4K21.99162735
23SGK2231.97801221
24SGK4941.97801221
25TTK1.97432751
26BCR1.97247857
27INSRR1.96946202
28NEK11.94061347
29MAP3K141.81677250
30FGFR21.81316838
31YES11.78867221
32SGK31.76286454
33RPS6KB21.64883309
34BUB11.59537704
35FGFR31.59154425
36PLK21.57246333
37CHEK21.55902268
38TRPM71.53766740
39SIK31.42583774
40PIK3CA1.38790652
41BRD41.37260857
42MAP3K91.34220855
43PLK31.33741062
44STK31.33016438
45STK38L1.28474898
46CAMKK21.26024042
47BMPR21.25525475
48EPHA31.22524023
49ATR1.22105000
50CDK61.19853878
51CDK121.18878917
52CDK81.18019095
53CDK71.16248769
54TIE11.15408934
55EPHB21.07865652
56RPS6KA41.06723063
57EIF2AK21.05441568
58STK241.04810583
59BRSK21.04761686
60AURKB1.04133867
61PLK11.03322340
62VRK10.98740564
63MAPKAPK50.96806010
64MST1R0.96714334
65NEK60.95871975
66RPS6KB10.93915406
67PRKCE0.93352271
68CHEK10.87925808
69CAMK1D0.86056797
70LIMK10.85555336
71NEK20.85102715
72PIM20.83290250
73DDR20.82452703
74IRAK30.82330619
75FGFR10.80790612
76PRKD30.77243851
77BRSK10.76407466
78PASK0.76165118
79NLK0.72641411
80CHUK0.72146223
81MAP2K70.72098264
82MAPKAPK30.71665093
83MAPK130.71558667
84IRAK40.69818593
85TEC0.69406200
86CLK10.66420509
87STK390.65939435
88ICK0.65930414
89CDK90.65834900
90IRAK10.65089997
91SIK10.64704635
92SMG10.64520052
93MET0.64276425
94VRK20.62558167
95WNK10.61762192
96CDK30.60925280
97PRKCH0.60568923
98MST40.60520329
99FER0.58798663
100PAK20.58625394
101PKN10.58412340
102MELK0.58099135
103ERBB40.56639801
104CDK10.54708686
105TGFBR10.51144658
106MYLK0.51032383
107PINK10.49899221
108LATS20.49886246
109IGF1R0.49669091
110KSR10.48981939
111ROCK10.48285317
112PDGFRA0.47858626
113ADRBK10.45339666
114CDK40.45224279
115CSNK1E0.44718154
116RPS6KA20.44488635
117GSK3A0.42372274
118CDK20.42190197
119RPS6KA50.41486089
120PKN20.40973798
121MAP3K20.40396116
122DYRK20.40277514
123EIF2AK30.39909423
124SRPK10.39065675
125PLK40.38994138
126CAMK1G0.38657067
127TAOK20.38485675
128TRIM280.38381289
129AURKA0.37830190
130MTOR0.37189067
131CAMKK10.36100210
132MAPK110.35843750
133AKT20.35478377
134OBSCN0.34718512
135PBK0.34536411
136SGK10.34111651
137GRK10.34082016
138RAF10.33129825
139EIF2AK10.32926092
140PRKDC0.32760933
141IRAK20.32632589
142OXSR10.32290870
143RPS6KC10.32157190
144RPS6KL10.32157190
145PDGFRB0.31623528
146CSNK1A1L0.31526598
147RPS6KA60.31258509
148MAPK70.31223514
149PRKG10.30965132
150ADRBK20.30905345
151DMPK0.29936892
152ATM0.29807460
153JAK30.29577355
154PRKCQ0.28494143

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.45578820
2One carbon pool by folate_Homo sapiens_hsa006703.30852022
3Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.28048509
4Mismatch repair_Homo sapiens_hsa034303.03935292
5Fanconi anemia pathway_Homo sapiens_hsa034602.93470594
6Homologous recombination_Homo sapiens_hsa034402.83232997
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.82960841
8Selenocompound metabolism_Homo sapiens_hsa004502.76699819
9RNA transport_Homo sapiens_hsa030132.46361716
10Protein export_Homo sapiens_hsa030602.41058062
11Nucleotide excision repair_Homo sapiens_hsa034202.38203324
12TGF-beta signaling pathway_Homo sapiens_hsa043502.34443341
13RNA polymerase_Homo sapiens_hsa030202.12078302
14ECM-receptor interaction_Homo sapiens_hsa045122.09496113
15Sulfur metabolism_Homo sapiens_hsa009202.07223302
16Vitamin B6 metabolism_Homo sapiens_hsa007502.04616408
17Prostate cancer_Homo sapiens_hsa052151.96599090
18RNA degradation_Homo sapiens_hsa030181.94038523
19Adherens junction_Homo sapiens_hsa045201.87393876
20Melanoma_Homo sapiens_hsa052181.86347585
21Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.85230973
22Focal adhesion_Homo sapiens_hsa045101.77922975
23Steroid biosynthesis_Homo sapiens_hsa001001.76880158
24SNARE interactions in vesicular transport_Homo sapiens_hsa041301.69432229
25Spliceosome_Homo sapiens_hsa030401.68649294
26Base excision repair_Homo sapiens_hsa034101.64252484
27Pyrimidine metabolism_Homo sapiens_hsa002401.57773998
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.56608945
29PI3K-Akt signaling pathway_Homo sapiens_hsa041511.56085345
30Fatty acid biosynthesis_Homo sapiens_hsa000611.54574179
31Hippo signaling pathway_Homo sapiens_hsa043901.54460659
32MicroRNAs in cancer_Homo sapiens_hsa052061.53053672
33Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.52975227
34mRNA surveillance pathway_Homo sapiens_hsa030151.50200812
35Thyroid cancer_Homo sapiens_hsa052161.48941032
36Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.46562655
37Viral myocarditis_Homo sapiens_hsa054161.45198086
38Autoimmune thyroid disease_Homo sapiens_hsa053201.42638452
39Basal cell carcinoma_Homo sapiens_hsa052171.42010627
40Propanoate metabolism_Homo sapiens_hsa006401.40457867
41Lysine degradation_Homo sapiens_hsa003101.39613159
42Cysteine and methionine metabolism_Homo sapiens_hsa002701.39469000
43Malaria_Homo sapiens_hsa051441.38354025
44Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.36017631
45Small cell lung cancer_Homo sapiens_hsa052221.31146221
46Proteoglycans in cancer_Homo sapiens_hsa052051.29858588
47Endometrial cancer_Homo sapiens_hsa052131.25187478
48Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.20775364
49Fatty acid elongation_Homo sapiens_hsa000621.19678053
50Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.18182685
51Transcriptional misregulation in cancer_Homo sapiens_hsa052021.17000122
52Pathways in cancer_Homo sapiens_hsa052001.16769916
53Phagosome_Homo sapiens_hsa041451.11055467
54AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.05924512
55Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.05516577
56Purine metabolism_Homo sapiens_hsa002301.04269194
57Cell cycle_Homo sapiens_hsa041101.04052866
58Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.00483858
59Hedgehog signaling pathway_Homo sapiens_hsa043401.00321213
60Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.99567579
61Wnt signaling pathway_Homo sapiens_hsa043100.99525199
62FoxO signaling pathway_Homo sapiens_hsa040680.96976780
63Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.96196903
64Axon guidance_Homo sapiens_hsa043600.95532879
65Arachidonic acid metabolism_Homo sapiens_hsa005900.95362750
66Toxoplasmosis_Homo sapiens_hsa051450.92019724
67Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.91693701
68Bladder cancer_Homo sapiens_hsa052190.91002970
69Pyruvate metabolism_Homo sapiens_hsa006200.90250969
70Sphingolipid metabolism_Homo sapiens_hsa006000.90050391
71Butanoate metabolism_Homo sapiens_hsa006500.89789491
72Hepatitis B_Homo sapiens_hsa051610.87043999
73Regulation of actin cytoskeleton_Homo sapiens_hsa048100.86825813
74Nitrogen metabolism_Homo sapiens_hsa009100.86754797
75Tight junction_Homo sapiens_hsa045300.86238216
76Oocyte meiosis_Homo sapiens_hsa041140.83848921
77Ovarian steroidogenesis_Homo sapiens_hsa049130.83846297
78Protein digestion and absorption_Homo sapiens_hsa049740.83136331
79Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.82774271
80Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.81369406
81Allograft rejection_Homo sapiens_hsa053300.81236438
82Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.80524349
83Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.80098828
84Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.78812658
85Pancreatic cancer_Homo sapiens_hsa052120.78623839
86Legionellosis_Homo sapiens_hsa051340.77979525
87Rheumatoid arthritis_Homo sapiens_hsa053230.77829520
88Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.77693527
89Ras signaling pathway_Homo sapiens_hsa040140.76326238
90Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.74127247
91Jak-STAT signaling pathway_Homo sapiens_hsa046300.73703925
92Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.73693267
93Basal transcription factors_Homo sapiens_hsa030220.73467106
94Fatty acid metabolism_Homo sapiens_hsa012120.72812592
95PPAR signaling pathway_Homo sapiens_hsa033200.72162333
96Toll-like receptor signaling pathway_Homo sapiens_hsa046200.69803009
97Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.68956292
98Dilated cardiomyopathy_Homo sapiens_hsa054140.66694681
99Melanogenesis_Homo sapiens_hsa049160.66416843
100ErbB signaling pathway_Homo sapiens_hsa040120.66062817
101Non-small cell lung cancer_Homo sapiens_hsa052230.64779260
102Prolactin signaling pathway_Homo sapiens_hsa049170.64380111
103HTLV-I infection_Homo sapiens_hsa051660.64172703
104Hepatitis C_Homo sapiens_hsa051600.63726025
105Circadian rhythm_Homo sapiens_hsa047100.63713335
106Measles_Homo sapiens_hsa051620.63678162
107Amoebiasis_Homo sapiens_hsa051460.63415319
108Rap1 signaling pathway_Homo sapiens_hsa040150.63127903
109Shigellosis_Homo sapiens_hsa051310.62908827
110Biosynthesis of amino acids_Homo sapiens_hsa012300.61246888
111Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.61199493
112Ribosome_Homo sapiens_hsa030100.59935667
113Viral carcinogenesis_Homo sapiens_hsa052030.59203907
114Colorectal cancer_Homo sapiens_hsa052100.59168134
115Thyroid hormone signaling pathway_Homo sapiens_hsa049190.58889706
116Chronic myeloid leukemia_Homo sapiens_hsa052200.58734483
117Alcoholism_Homo sapiens_hsa050340.58371173
118Glioma_Homo sapiens_hsa052140.58043461
119Non-homologous end-joining_Homo sapiens_hsa034500.57552545
120Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.57233326
121Salmonella infection_Homo sapiens_hsa051320.56585339
122NF-kappa B signaling pathway_Homo sapiens_hsa040640.55642106
123Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.55360281
124Ether lipid metabolism_Homo sapiens_hsa005650.55207228
125p53 signaling pathway_Homo sapiens_hsa041150.54629184
126TNF signaling pathway_Homo sapiens_hsa046680.54576864
127Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.53899473
128N-Glycan biosynthesis_Homo sapiens_hsa005100.53596503
129Maturity onset diabetes of the young_Homo sapiens_hsa049500.52794831
130Leukocyte transendothelial migration_Homo sapiens_hsa046700.52354843
131Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.49993636
132Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.49700881
133mTOR signaling pathway_Homo sapiens_hsa041500.49524191
134Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.49315133
135Renal cell carcinoma_Homo sapiens_hsa052110.48852925
136Renin-angiotensin system_Homo sapiens_hsa046140.47981920
137Graft-versus-host disease_Homo sapiens_hsa053320.47964773
138Inositol phosphate metabolism_Homo sapiens_hsa005620.47497857
139Type I diabetes mellitus_Homo sapiens_hsa049400.47455396
140Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.46996615
141Central carbon metabolism in cancer_Homo sapiens_hsa052300.46977101
142Carbon metabolism_Homo sapiens_hsa012000.45282638
143Thyroid hormone synthesis_Homo sapiens_hsa049180.41542418
144Systemic lupus erythematosus_Homo sapiens_hsa053220.40439237
145Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.37942649
146Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.37447723
147Longevity regulating pathway - mammal_Homo sapiens_hsa042110.36255686
148Folate biosynthesis_Homo sapiens_hsa007900.34780960
149Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.32829505
150Tryptophan metabolism_Homo sapiens_hsa003800.31331508
151Estrogen signaling pathway_Homo sapiens_hsa049150.31315084
152beta-Alanine metabolism_Homo sapiens_hsa004100.29867158
153AMPK signaling pathway_Homo sapiens_hsa041520.28701786
154Metabolic pathways_Homo sapiens_hsa011000.25391757
155Epstein-Barr virus infection_Homo sapiens_hsa051690.25351036
156Steroid hormone biosynthesis_Homo sapiens_hsa001400.24219593
157Peroxisome_Homo sapiens_hsa041460.23899164
158Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.22961454
159Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.22714228
160Dorso-ventral axis formation_Homo sapiens_hsa043200.19121290

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