LRRC6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene contains several leucine-rich repeat domains and appears to be involved in the motility of cilia. Defects in this gene are a cause of primary ciliary dyskinesia-19 (CILD19). Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 4, 11 and 22. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* epithelial cilium movement (GO:0003351)9.99337446
2acrosome assembly (GO:0001675)9.42016748
3cell wall macromolecule catabolic process (GO:0016998)9.34916852
4cell wall macromolecule metabolic process (GO:0044036)9.34916852
5* sperm motility (GO:0030317)9.25428007
6multicellular organism reproduction (GO:0032504)9.11687510
7sperm-egg recognition (GO:0035036)8.49190111
8plasma membrane fusion (GO:0045026)8.36034220
9acrosome reaction (GO:0007340)7.85280736
10binding of sperm to zona pellucida (GO:0007339)7.67233435
11cell-cell recognition (GO:0009988)7.56837332
12reproduction (GO:0000003)7.39416050
13* motile cilium assembly (GO:0044458)7.22887404
14spermatid development (GO:0007286)7.13364089
15* epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.10032869
16piRNA metabolic process (GO:0034587)7.06988609
17regulation of cilium movement (GO:0003352)6.85386305
18ventricular system development (GO:0021591)6.84447516
19male meiosis (GO:0007140)6.79511032
20single fertilization (GO:0007338)6.31255634
21synaptonemal complex organization (GO:0070193)5.93814636
22axoneme assembly (GO:0035082)5.80078268
23negative regulation of inclusion body assembly (GO:0090084)5.46117964
24protein localization to cilium (GO:0061512)5.45847885
25synaptonemal complex assembly (GO:0007130)5.38629515
26sperm capacitation (GO:0048240)5.34259020
27fertilization (GO:0009566)5.22960980
28intraciliary transport (GO:0042073)5.07315785
29GTP biosynthetic process (GO:0006183)4.96472274
30calcium ion-dependent exocytosis (GO:0017156)4.91505937
31nonmotile primary cilium assembly (GO:0035058)4.90794635
32nucleoside diphosphate phosphorylation (GO:0006165)4.79486869
33microtubule polymerization or depolymerization (GO:0031109)4.68259288
34spermatogenesis (GO:0007283)4.66425128
35male gamete generation (GO:0048232)4.64369178
36DNA methylation involved in gamete generation (GO:0043046)4.55903411
37microtubule severing (GO:0051013)4.55130663
38male meiosis I (GO:0007141)4.46655216
39regulation of inclusion body assembly (GO:0090083)4.43536838
40substrate-independent telencephalic tangential interneuron migration (GO:0021843)4.38614328
41substrate-independent telencephalic tangential migration (GO:0021826)4.38614328
42UTP biosynthetic process (GO:0006228)4.30632388
43gamete generation (GO:0007276)4.30164379
44retinal rod cell development (GO:0046548)4.27451475
45cell recognition (GO:0008037)4.27364367
46spermatid nucleus differentiation (GO:0007289)4.18464031
47* cilium organization (GO:0044782)4.13186080
48left/right pattern formation (GO:0060972)4.03713007
49germ cell development (GO:0007281)4.03216993
50cilium morphogenesis (GO:0060271)4.01675687
51regulation of microtubule-based movement (GO:0060632)4.01129828
52left/right axis specification (GO:0070986)4.01033060
53cellular process involved in reproduction in multicellular organism (GO:0022412)3.99316531
54smoothened signaling pathway (GO:0007224)3.99109028
55microtubule depolymerization (GO:0007019)3.97284059
56* cilium assembly (GO:0042384)3.96291361
57determination of left/right symmetry (GO:0007368)3.86542814
58UTP metabolic process (GO:0046051)3.85259782
59* microtubule-based movement (GO:0007018)3.77164309
60determination of bilateral symmetry (GO:0009855)3.67638295
61specification of symmetry (GO:0009799)3.62245809
62chromosome organization involved in meiosis (GO:0070192)3.60595055
63protein polyglutamylation (GO:0018095)3.60214994
64* cellular component assembly involved in morphogenesis (GO:0010927)3.59955254
65meiotic nuclear division (GO:0007126)3.59753316
66meiosis I (GO:0007127)3.51775580
67guanosine-containing compound biosynthetic process (GO:1901070)3.49098388
68organic cation transport (GO:0015695)3.38489595
69multicellular organismal reproductive process (GO:0048609)3.38196850
70retinal cone cell development (GO:0046549)3.36777386
71intra-S DNA damage checkpoint (GO:0031573)3.34396427
72meiotic cell cycle (GO:0051321)3.33209618
73lactate metabolic process (GO:0006089)3.21115647
74* microtubule-based process (GO:0007017)3.15797349
75lateral ventricle development (GO:0021670)3.13803889
76CTP biosynthetic process (GO:0006241)3.07582822
77CTP metabolic process (GO:0046036)3.07582822
78response to pheromone (GO:0019236)3.03740956
79photoreceptor cell maintenance (GO:0045494)3.01955232
80protein K11-linked deubiquitination (GO:0035871)3.00104946
81* organelle assembly (GO:0070925)2.99378042
82microtubule bundle formation (GO:0001578)2.97482733
83glycerol ether metabolic process (GO:0006662)2.97364381
84diterpenoid biosynthetic process (GO:0016102)2.91230866
85seminiferous tubule development (GO:0072520)2.87381874
86centriole assembly (GO:0098534)2.81681831
87regulation of meiosis I (GO:0060631)2.81341410
88protein refolding (GO:0042026)2.78459677
89ether metabolic process (GO:0018904)2.76127890
90polyol catabolic process (GO:0046174)2.75775942
91one-carbon compound transport (GO:0019755)2.75415996
92negative regulation of response to food (GO:0032096)2.74961666
93negative regulation of appetite (GO:0032099)2.74961666
94membrane depolarization during action potential (GO:0086010)2.74701348
95neural tube formation (GO:0001841)2.74122076
96pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.71892869
97regulation of protein kinase A signaling (GO:0010738)2.71739006
98lateral sprouting from an epithelium (GO:0060601)2.70825082
99centriole replication (GO:0007099)2.69954190
100protein localization to synapse (GO:0035418)2.68956053
101ATP hydrolysis coupled proton transport (GO:0015991)2.67537713
102energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.67537713
103appendage development (GO:0048736)2.67379868
104limb development (GO:0060173)2.67379868
105primary alcohol catabolic process (GO:0034310)2.66719280
106neuron fate determination (GO:0048664)2.66188410
107cytoplasmic microtubule organization (GO:0031122)2.65189568
108chaperone-mediated protein complex assembly (GO:0051131)2.63913658
109cerebral cortex radially oriented cell migration (GO:0021799)2.62701542
110genitalia morphogenesis (GO:0035112)2.59812297
111multicellular organismal development (GO:0007275)2.57179765
112dorsal/ventral pattern formation (GO:0009953)2.56775894
113calcium ion import (GO:0070509)2.56482689
114monoubiquitinated protein deubiquitination (GO:0035520)2.56168598
115alditol metabolic process (GO:0019400)2.56038365
116nucleotide phosphorylation (GO:0046939)2.55358287
117establishment of planar polarity (GO:0001736)2.55345119
118establishment of tissue polarity (GO:0007164)2.55345119
119glycerol metabolic process (GO:0006071)2.54775647
120pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.54516872
121neuron cell-cell adhesion (GO:0007158)2.54246705
122vocalization behavior (GO:0071625)2.53604004
123* cell projection assembly (GO:0030031)2.53199994
124CDP-diacylglycerol biosynthetic process (GO:0016024)2.49792936
125response to xenobiotic stimulus (GO:0009410)2.48851875
126glomerular epithelial cell development (GO:0072310)2.48366722
127protein targeting to Golgi (GO:0000042)2.48221406
128pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.47784635
129asymmetric protein localization (GO:0008105)2.47078741
130glycolytic process (GO:0006096)2.46320046
131negative regulation of immunoglobulin mediated immune response (GO:0002890)2.46199278
132negative regulation of B cell mediated immunity (GO:0002713)2.46199278
133negative regulation of organelle assembly (GO:1902116)2.44776529
134brain morphogenesis (GO:0048854)2.42823372
135CDP-diacylglycerol metabolic process (GO:0046341)2.39922840
136pyrimidine-containing compound transmembrane transport (GO:0072531)2.39877149
137regulation of collateral sprouting (GO:0048670)2.39302367
138microtubule-based transport (GO:0010970)2.39217758
139heart looping (GO:0001947)2.35399302
140apical protein localization (GO:0045176)2.35242182
141spinal cord motor neuron differentiation (GO:0021522)2.34347465
142synaptic vesicle endocytosis (GO:0048488)2.32329542
143telencephalon cell migration (GO:0022029)2.31744676
144retina layer formation (GO:0010842)2.31677567
145regulation of smoothened signaling pathway (GO:0008589)2.30570971
146sequestering of actin monomers (GO:0042989)2.27703133
147cytoskeleton-dependent intracellular transport (GO:0030705)2.26414649
148glutathione derivative metabolic process (GO:1901685)2.25552889
149glutathione derivative biosynthetic process (GO:1901687)2.25552889
150phosphorelay signal transduction system (GO:0000160)2.24366554
151forebrain cell migration (GO:0021885)2.21517786
152vitamin transmembrane transport (GO:0035461)2.20286432
153ethanol metabolic process (GO:0006067)2.19460603
154terpenoid biosynthetic process (GO:0016114)2.17051893
155photoreceptor cell development (GO:0042461)2.14554349
156presynaptic membrane organization (GO:0097090)2.12697528
157embryonic heart tube morphogenesis (GO:0003143)2.12681999
158photoreceptor cell differentiation (GO:0046530)2.12493957
159eye photoreceptor cell differentiation (GO:0001754)2.12493957
160cerebral cortex cell migration (GO:0021795)2.10726300
161cilium or flagellum-dependent cell motility (GO:0001539)13.1685045
162* axonemal dynein complex assembly (GO:0070286)10.8356479
163fusion of sperm to egg plasma membrane (GO:0007342)10.6714958
164* cilium movement (GO:0003341)10.3304927

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.81283427
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse5.48937077
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.06747390
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.19930146
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.73029696
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.47542346
7GBX2_23144817_ChIP-Seq_PC3_Human2.40699648
8FLI1_27457419_Chip-Seq_LIVER_Mouse2.40386506
9TAF15_26573619_Chip-Seq_HEK293_Human2.39740797
10ZFP57_27257070_Chip-Seq_ESCs_Mouse2.24039379
11ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.22836209
12PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.21653953
13GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.18778519
14* CTBP2_25329375_ChIP-Seq_LNCAP_Human2.15103036
15CBX2_27304074_Chip-Seq_ESCs_Mouse2.13385229
16PIAS1_25552417_ChIP-Seq_VCAP_Human2.12715959
17PCGF2_27294783_Chip-Seq_ESCs_Mouse2.11259569
18CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.07444763
19VDR_22108803_ChIP-Seq_LS180_Human2.04790709
20* REST_21632747_ChIP-Seq_MESCs_Mouse1.99168983
21NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.96412798
22NR3C1_21868756_ChIP-Seq_MCF10A_Human1.81707001
23RNF2_27304074_Chip-Seq_NSC_Mouse1.78851032
24ZNF274_21170338_ChIP-Seq_K562_Hela1.75776323
25IGF1R_20145208_ChIP-Seq_DFB_Human1.71766724
26TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.68087153
27CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.67997451
28KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.67193430
29POU3F2_20337985_ChIP-ChIP_501MEL_Human1.64891945
30SMAD4_21799915_ChIP-Seq_A2780_Human1.64344848
31FUS_26573619_Chip-Seq_HEK293_Human1.63903176
32EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.61568280
33AR_21572438_ChIP-Seq_LNCaP_Human1.61512861
34CTBP1_25329375_ChIP-Seq_LNCAP_Human1.61304809
35NANOG_18555785_Chip-Seq_ESCs_Mouse1.55250663
36SUZ12_27294783_Chip-Seq_NPCs_Mouse1.51954735
37TCF4_22108803_ChIP-Seq_LS180_Human1.50899270
38EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.50793396
39* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.50680111
40FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.49785226
41FOXM1_26456572_ChIP-Seq_MCF-7_Human1.47751614
42ER_23166858_ChIP-Seq_MCF-7_Human1.47302814
43TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.47282297
44KDM2B_26808549_Chip-Seq_REH_Human1.45913461
45TAL1_26923725_Chip-Seq_HPCs_Mouse1.45892961
46P300_19829295_ChIP-Seq_ESCs_Human1.45411668
47PCGF2_27294783_Chip-Seq_NPCs_Mouse1.43179280
48NFE2_27457419_Chip-Seq_LIVER_Mouse1.42963895
49SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.42001778
50GATA1_26923725_Chip-Seq_HPCs_Mouse1.41939527
51EWS_26573619_Chip-Seq_HEK293_Human1.40845823
52MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.40686936
53MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.40683558
54RUNX2_22187159_ChIP-Seq_PCA_Human1.39816849
55P53_22387025_ChIP-Seq_ESCs_Mouse1.39173659
56CBP_20019798_ChIP-Seq_JUKART_Human1.37172246
57IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.37172246
58OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37168192
59SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.35890471
60POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.34238567
61TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34238567
62FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.32623241
63CMYC_18555785_Chip-Seq_ESCs_Mouse1.32215571
64* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32049279
65SMAD3_21741376_ChIP-Seq_EPCs_Human1.30427014
66* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.29910696
67FLI1_21867929_ChIP-Seq_TH2_Mouse1.28696557
68TOP2B_26459242_ChIP-Seq_MCF-7_Human1.28010667
69TBL1_22424771_ChIP-Seq_293T_Human1.27972843
70UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.25260311
71ZNF217_24962896_ChIP-Seq_MCF-7_Human1.25161749
72TCF4_23295773_ChIP-Seq_U87_Human1.24980318
73ELK4_26923725_Chip-Seq_MESODERM_Mouse1.24488192
74SALL1_21062744_ChIP-ChIP_HESCs_Human1.24465002
75SUZ12_18555785_Chip-Seq_ESCs_Mouse1.23873358
76AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.23256821
77EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.23215143
78P300_18555785_Chip-Seq_ESCs_Mouse1.23091744
79SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.22615941
80PRDM14_20953172_ChIP-Seq_ESCs_Human1.22117713
81E2F1_18555785_Chip-Seq_ESCs_Mouse1.21620187
82SOX2_21211035_ChIP-Seq_LN229_Gbm1.21239032
83AHR_22903824_ChIP-Seq_MCF-7_Human1.21238983
84STAT3_18555785_Chip-Seq_ESCs_Mouse1.20979103
85OCT4_18555785_Chip-Seq_ESCs_Mouse1.19642900
86SOX2_18555785_Chip-Seq_ESCs_Mouse1.19027736
87BMI1_23680149_ChIP-Seq_NPCS_Mouse1.18134416
88* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18130104
89BCAT_22108803_ChIP-Seq_LS180_Human1.17916003
90SOX9_26525672_Chip-Seq_HEART_Mouse1.17259800
91* REST_18959480_ChIP-ChIP_MESCs_Mouse1.17068989
92DROSHA_22980978_ChIP-Seq_HELA_Human1.16672374
93STAT3_23295773_ChIP-Seq_U87_Human1.14950934
94WDR5_24793694_ChIP-Seq_LNCAP_Human1.14587511
95E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.13891254
96CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.13599181
97SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.13426391
98GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.12319834
99P53_22127205_ChIP-Seq_FIBROBLAST_Human1.12035619
100EZH2_27294783_Chip-Seq_NPCs_Mouse1.11328858
101TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.11304504
102AR_25329375_ChIP-Seq_VCAP_Human1.10717159
103NFYA_21822215_ChIP-Seq_K562_Human1.10393203
104CBP_21632823_ChIP-Seq_H3396_Human1.10097772
105CRX_20693478_ChIP-Seq_RETINA_Mouse1.09887964
106CDX2_19796622_ChIP-Seq_MESCs_Mouse1.09714167
107KLF4_18555785_Chip-Seq_ESCs_Mouse1.09692181
108RUNX1_27457419_Chip-Seq_LIVER_Mouse1.09253492
109STAT1_17558387_ChIP-Seq_HELA_Human1.09121092
110* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.08184890
111CTNNB1_20460455_ChIP-Seq_HCT116_Human1.08012582
112SUZ12_27294783_Chip-Seq_ESCs_Mouse1.08006384
113PHF8_20622853_ChIP-Seq_HELA_Human1.07971103
114PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.07278167
115CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.06986138
116NFYB_21822215_ChIP-Seq_K562_Human1.06942139
117TP53_16413492_ChIP-PET_HCT116_Human1.06834109
118SMAD3_21741376_ChIP-Seq_ESCs_Human1.06120290
119KAP1_22055183_ChIP-Seq_ESCs_Mouse1.05307958
120SMAD4_21741376_ChIP-Seq_EPCs_Human1.05232133
121JUN_21703547_ChIP-Seq_K562_Human1.04834287
122EZH2_27294783_Chip-Seq_ESCs_Mouse1.04299695
123ETV1_20927104_ChIP-Seq_GIST48_Human1.04040330
124MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.03795717
125AR_19668381_ChIP-Seq_PC3_Human1.03493879
126CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03255586
127NANOG_19829295_ChIP-Seq_ESCs_Human1.03083577
128SOX2_19829295_ChIP-Seq_ESCs_Human1.03083577
129ESRRB_18555785_Chip-Seq_ESCs_Mouse1.02692188
130CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.01905015
131CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.01498296
132PU1_27457419_Chip-Seq_LIVER_Mouse1.00675307
133SMRT_27268052_Chip-Seq_Bcells_Human0.99481717
134ARNT_22903824_ChIP-Seq_MCF-7_Human0.99305560
135HNFA_21074721_ChIP-Seq_CACO-2_Human0.99263413
136NMYC_18555785_Chip-Seq_ESCs_Mouse0.99088654
137CTCF_18555785_Chip-Seq_ESCs_Mouse0.98935741
138SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98343705
139MTF2_20144788_ChIP-Seq_MESCs_Mouse0.98088624
140RBPJ_22232070_ChIP-Seq_NCS_Mouse0.97865203
141ZFX_18555785_Chip-Seq_ESCs_Mouse0.97078128

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive4.23173526
2MP0008877_abnormal_DNA_methylation3.80475641
3MP0001929_abnormal_gametogenesis3.76628257
4MP0003880_abnormal_central_pattern3.51365585
5MP0003878_abnormal_ear_physiology3.33112869
6MP0005377_hearing/vestibular/ear_phenot3.33112869
7MP0002653_abnormal_ependyma_morphology3.18766407
8MP0009046_muscle_twitch3.09188932
9MP0008789_abnormal_olfactory_epithelium3.04093092
10MP0001984_abnormal_olfaction2.96123609
11MP0004859_abnormal_synaptic_plasticity2.74022211
12MP0000569_abnormal_digit_pigmentation2.52434973
13MP0005499_abnormal_olfactory_system2.50042997
14MP0005394_taste/olfaction_phenotype2.50042997
15MP0002210_abnormal_sex_determination2.47557177
16MP0003635_abnormal_synaptic_transmissio2.46586052
17MP0009745_abnormal_behavioral_response2.32679025
18MP0001968_abnormal_touch/_nociception2.32046848
19MP0002161_abnormal_fertility/fecundity2.31340221
20MP0002736_abnormal_nociception_after2.24250797
21MP0002822_catalepsy2.20901899
22MP0005623_abnormal_meninges_morphology2.18005691
23MP0002064_seizures2.06693559
24MP0002132_abnormal_respiratory_system2.06590587
25MP0002572_abnormal_emotion/affect_behav2.06113294
26MP0002063_abnormal_learning/memory/cond2.04022274
27MP0001145_abnormal_male_reproductive2.02933629
28MP0005410_abnormal_fertilization10.0277761
29MP0001440_abnormal_grooming_behavior1.99640066
30MP0008875_abnormal_xenobiotic_pharmacok1.99599878
31MP0006292_abnormal_olfactory_placode1.94317914
32MP0004885_abnormal_endolymph1.92874054
33MP0004270_analgesia1.89556833
34MP0000566_synostosis1.83988718
35MP0000653_abnormal_sex_gland1.83672685
36MP0001293_anophthalmia1.80104943
37MP0005646_abnormal_pituitary_gland1.78705537
38MP0010030_abnormal_orbit_morphology1.72477889
39MP0002272_abnormal_nervous_system1.70017163
40MP0000383_abnormal_hair_follicle1.68558400
41MP0002160_abnormal_reproductive_system1.67768943
42MP0004043_abnormal_pH_regulation1.65937393
43MP0001486_abnormal_startle_reflex1.62836857
44MP0005248_abnormal_Harderian_gland1.61168501
45MP0002734_abnormal_mechanical_nocicepti1.52881507
46MP0009780_abnormal_chondrocyte_physiolo1.49775839
47MP0001529_abnormal_vocalization1.46480532
48MP0001501_abnormal_sleep_pattern1.43971618
49MP0002735_abnormal_chemical_nociception1.39121009
50MP0002277_abnormal_respiratory_mucosa1.38356444
51MP0002067_abnormal_sensory_capabilities1.37591726
52MP0006276_abnormal_autonomic_nervous1.36117433
53MP0002233_abnormal_nose_morphology1.35793759
54MP0008004_abnormal_stomach_pH1.33780647
55MP0001346_abnormal_lacrimal_gland1.32579151
56MP0002557_abnormal_social/conspecific_i1.32180500
57MP0003646_muscle_fatigue1.29693251
58MP0002638_abnormal_pupillary_reflex1.29217940
59MP0001905_abnormal_dopamine_level1.26881808
60MP0003879_abnormal_hair_cell1.24781911
61MP0003938_abnormal_ear_development1.23877669
62MP0000778_abnormal_nervous_system1.23000248
63MP0003136_yellow_coat_color1.22307081
64MP0005195_abnormal_posterior_eye1.17393041
65MP0005551_abnormal_eye_electrophysiolog1.17226455
66MP0000049_abnormal_middle_ear1.16212532
67MP0004924_abnormal_behavior1.14117022
68MP0005386_behavior/neurological_phenoty1.14117022
69MP0010678_abnormal_skin_adnexa1.11460872
70MP0001765_abnormal_ion_homeostasis1.09226382
71MP0003787_abnormal_imprinting1.08106795
72MP0002102_abnormal_ear_morphology1.07636724
73MP0002837_dystrophic_cardiac_calcinosis1.07378923
74MP0004811_abnormal_neuron_physiology1.03432705
75MP0001970_abnormal_pain_threshold1.01547596
76MP0003121_genomic_imprinting1.00907406
77MP0002184_abnormal_innervation1.00189536
78MP0002282_abnormal_trachea_morphology1.00153382
79MP0005423_abnormal_somatic_nervous0.99102484
80MP0004233_abnormal_muscle_weight0.98636900
81MP0001324_abnormal_eye_pigmentation0.98351776
82MP0000427_abnormal_hair_cycle0.97929735
83MP0003329_amyloid_beta_deposits0.96049026
84MP0004142_abnormal_muscle_tone0.94385341
85MP0003633_abnormal_nervous_system0.93500306
86MP0008569_lethality_at_weaning0.92829530
87MP0002733_abnormal_thermal_nociception0.92793577
88MP0005389_reproductive_system_phenotype0.91280476
89MP0003937_abnormal_limbs/digits/tail_de0.91232437
90MP0002882_abnormal_neuron_morphology0.90077896
91MP0002876_abnormal_thyroid_physiology0.90060401
92MP0005391_vision/eye_phenotype0.89752148
93MP0006072_abnormal_retinal_apoptosis0.89564819
94MP0003119_abnormal_digestive_system0.89424563
95MP0002152_abnormal_brain_morphology0.88964315
96MP0002066_abnormal_motor_capabilities/c0.87221673
97MP0005167_abnormal_blood-brain_barrier0.81002320
98MP0003890_abnormal_embryonic-extraembry0.80603738
99MP0001963_abnormal_hearing_physiology0.78489982
100MP0004019_abnormal_vitamin_homeostasis0.77841730
101MP0000955_abnormal_spinal_cord0.77683102
102MP0005388_respiratory_system_phenotype0.77593792
103MP0002133_abnormal_respiratory_system0.77593792
104MP0002938_white_spotting0.76248100
105MP0003718_maternal_effect0.76065812
106MP0000631_abnormal_neuroendocrine_gland0.75954339
107MP0004145_abnormal_muscle_electrophysio0.75704990
108MP0004742_abnormal_vestibular_system0.75662286
109MP0005535_abnormal_body_temperature0.74254111
110MP0003631_nervous_system_phenotype0.72954818
111MP0002229_neurodegeneration0.72688631
112MP0005645_abnormal_hypothalamus_physiol0.69120020
113MP0003183_abnormal_peptide_metabolism0.68980967
114MP0004133_heterotaxia0.68301248
115MP0005670_abnormal_white_adipose0.68300274
116MP0001286_abnormal_eye_development0.68161019
117MP0008872_abnormal_physiological_respon0.67930398
118MP0005187_abnormal_penis_morphology0.67411399
119MP0002909_abnormal_adrenal_gland0.66214257
120MP0001188_hyperpigmentation0.65447181
121MP0003724_increased_susceptibility_to0.64948577
122MP0005647_abnormal_sex_gland0.64857880
123MP0002752_abnormal_somatic_nervous0.64603974
124MP0008995_early_reproductive_senescence0.64469757
125MP0001664_abnormal_digestion0.63532062
126MP0000013_abnormal_adipose_tissue0.59111202
127MP0010386_abnormal_urinary_bladder0.56182776
128MP0005253_abnormal_eye_physiology0.55971071
129MP0001502_abnormal_circadian_rhythm0.55948890
130MP0002928_abnormal_bile_duct0.54700038
131MP0003122_maternal_imprinting0.54501479
132MP0008057_abnormal_DNA_replication0.54010413
133MP0003861_abnormal_nervous_system0.52942427
134MP0004085_abnormal_heartbeat0.52749460
135MP0003634_abnormal_glial_cell0.52699950
136MP0001485_abnormal_pinna_reflex0.52016917
137MP0000751_myopathy0.51459871
138MP0002234_abnormal_pharynx_morphology0.51328660
139MP0002069_abnormal_eating/drinking_beha0.49618862
140MP0006035_abnormal_mitochondrial_morpho0.47315139
141MP0000026_abnormal_inner_ear0.46279573

Predicted human phenotypes

RankGene SetZ-score
1* Abnormal ciliary motility (HP:0012262)8.77331319
2* Abnormal respiratory motile cilium morphology (HP:0005938)8.30617546
3* Abnormal respiratory epithelium morphology (HP:0012253)8.30617546
4* Rhinitis (HP:0012384)8.12230551
5* Chronic bronchitis (HP:0004469)6.72790102
6Infertility (HP:0000789)5.34503351
7* Bronchiectasis (HP:0002110)4.64017573
8Nephronophthisis (HP:0000090)4.30176554
9Medial flaring of the eyebrow (HP:0010747)3.89588274
10Tubulointerstitial nephritis (HP:0001970)3.77607638
11* Nasal polyposis (HP:0100582)3.70607988
12* Bronchitis (HP:0012387)3.43741020
13Molar tooth sign on MRI (HP:0002419)3.39679260
14Abnormality of midbrain morphology (HP:0002418)3.39679260
15Abnormality of the renal medulla (HP:0100957)3.33468138
16Gait imbalance (HP:0002141)3.29529986
17Congenital primary aphakia (HP:0007707)3.22388988
18Pancreatic fibrosis (HP:0100732)2.95514554
19Nephrogenic diabetes insipidus (HP:0009806)2.90170035
20* Abnormality of the nasal mucosa (HP:0000433)2.88680994
21Male infertility (HP:0003251)2.71724988
22True hermaphroditism (HP:0010459)2.70327039
23Chronic sinusitis (HP:0011109)2.64108521
24Focal motor seizures (HP:0011153)2.55383764
25* Recurrent otitis media (HP:0000403)2.53803710
26Chronic hepatic failure (HP:0100626)2.50356347
27Tubulointerstitial abnormality (HP:0001969)2.49241391
28Poor coordination (HP:0002370)2.48142156
29Genital tract atresia (HP:0001827)2.44255372
30Fibular hypoplasia (HP:0003038)2.41764701
31Postaxial foot polydactyly (HP:0001830)2.38964774
32Vaginal atresia (HP:0000148)2.38431744
33* Recurrent sinusitis (HP:0011108)2.35069151
34Tubular atrophy (HP:0000092)2.32577386
35Congenital hepatic fibrosis (HP:0002612)2.15663621
36Cystic liver disease (HP:0006706)2.14781027
37Pancreatic cysts (HP:0001737)2.11073034
38Oculomotor apraxia (HP:0000657)2.10681001
39Abnormality of the lower motor neuron (HP:0002366)2.09848632
40Postaxial hand polydactyly (HP:0001162)2.09664147
41Stage 5 chronic kidney disease (HP:0003774)2.09079127
42Furrowed tongue (HP:0000221)2.06753575
43Supernumerary spleens (HP:0009799)2.05055905
44Abnormality of permanent molar morphology (HP:0011071)2.04772164
45Abnormality of the dental root (HP:0006486)2.04772164
46Taurodontia (HP:0000679)2.04772164
47Aplasia/Hypoplasia of the lens (HP:0008063)2.03495442
48Atonic seizures (HP:0010819)2.02951220
49Occipital encephalocele (HP:0002085)2.02333704
50Abnormality of dentin (HP:0010299)2.01946417
51Aplasia/Hypoplasia of the tongue (HP:0010295)2.01694049
52* Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.1549745
53* Abnormal respiratory motile cilium physiology (HP:0012261)10.4961273
54* Dynein arm defect of respiratory motile cilia (HP:0012255)10.4488306
55* Absent/shortened dynein arms (HP:0200106)10.4488306
56Epileptic encephalopathy (HP:0200134)1.99103031
57Hyperventilation (HP:0002883)1.98632210
58Asplenia (HP:0001746)1.96572227
59Chronic otitis media (HP:0000389)1.92771981
60Aplasia/Hypoplasia of the spleen (HP:0010451)1.92212264
61Abnormality of molar morphology (HP:0011070)1.89460525
62Abnormality of molar (HP:0011077)1.89460525
63Absent rod-and cone-mediated responses on ERG (HP:0007688)1.87029341
64Gaze-evoked nystagmus (HP:0000640)1.85015546
65Abnormality of the renal cortex (HP:0011035)1.84198403
66Abnormality of the dental pulp (HP:0006479)1.83350425
67Narrow forehead (HP:0000341)1.82771531
68Abnormal spermatogenesis (HP:0008669)1.81582692
69Atelectasis (HP:0100750)1.79662252
70Amyotrophic lateral sclerosis (HP:0007354)1.77296492
71Abnormal rod and cone electroretinograms (HP:0008323)1.76135645
72Bile duct proliferation (HP:0001408)1.75299066
73Abnormal biliary tract physiology (HP:0012439)1.75299066
74Median cleft lip (HP:0000161)1.73243163
75Focal seizures (HP:0007359)1.71407948
76Hyperactive renin-angiotensin system (HP:0000841)1.70109250
77Polydipsia (HP:0001959)1.68693863
78Abnormal drinking behavior (HP:0030082)1.68693863
79Papilledema (HP:0001085)1.68564468
80Prominent nasal bridge (HP:0000426)1.67997622
81Gonadotropin excess (HP:0000837)1.65228599
82Intellectual disability, moderate (HP:0002342)1.64755258
83Specific learning disability (HP:0001328)1.62829511
84Anophthalmia (HP:0000528)1.62786058
85Aplasia/Hypoplasia of the fibula (HP:0006492)1.59737631
86Aganglionic megacolon (HP:0002251)1.59544067
87Progressive cerebellar ataxia (HP:0002073)1.58376005
88Broad distal phalanx of finger (HP:0009836)1.57061948
89Tubulointerstitial fibrosis (HP:0005576)1.53524444
90Bony spicule pigmentary retinopathy (HP:0007737)1.50880727
91Abnormality of ocular smooth pursuit (HP:0000617)1.47759070
92Recurrent bronchitis (HP:0002837)1.46311570
93Polyuria (HP:0000103)1.46032767
94Sclerocornea (HP:0000647)1.45909876
95Multicystic kidney dysplasia (HP:0000003)1.43542288
96Bell-shaped thorax (HP:0001591)1.42732735
97Anencephaly (HP:0002323)1.42611945
98Male pseudohermaphroditism (HP:0000037)1.41242340
99Polyphagia (HP:0002591)1.40926245
100Renal dysplasia (HP:0000110)1.40618245
101Facial cleft (HP:0002006)1.40049889
102Abnormality of renal excretion (HP:0011036)1.39639127
103Broad foot (HP:0001769)1.39512020
104Dysmetric saccades (HP:0000641)1.39027732
105Preaxial hand polydactyly (HP:0001177)1.38632110
106Myokymia (HP:0002411)1.37309691
107Highly arched eyebrow (HP:0002553)1.36820508
108Optic nerve coloboma (HP:0000588)1.36508600
109Abnormality of saccadic eye movements (HP:0000570)1.34847990
110Short ribs (HP:0000773)1.34755877
111Holoprosencephaly (HP:0001360)1.33867068
112Nephropathy (HP:0000112)1.32782272
113Absence seizures (HP:0002121)1.32521658
114Progressive inability to walk (HP:0002505)1.32438697
115Decreased central vision (HP:0007663)1.32337516
116Abnormal gallbladder physiology (HP:0012438)1.31982610
117Cholecystitis (HP:0001082)1.31982610
118Retinitis pigmentosa (HP:0000510)1.31476030
119Azoospermia (HP:0000027)1.31206568
120Cone-rod dystrophy (HP:0000548)1.29810822
121Febrile seizures (HP:0002373)1.28984348
122Oligodactyly (hands) (HP:0001180)1.28808705
123Hypodontia (HP:0000668)1.28352118
124Portal hypertension (HP:0001409)1.27414843
125Decreased circulating renin level (HP:0003351)1.24080600
126Decreased testicular size (HP:0008734)1.22458652
127Abnormality of abdominal situs (HP:0011620)1.21080020
128Abdominal situs inversus (HP:0003363)1.21080020
129Astigmatism (HP:0000483)1.19586808
130Abnormal urine output (HP:0012590)1.18488372
131Elevated erythrocyte sedimentation rate (HP:0003565)1.18008158
132Long face (HP:0000276)1.17419564
133Oligohydramnios (HP:0001562)1.16379764

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK37.79212859
2PDK47.79212859
3PDK24.94932939
4PNCK4.06824350
5MST43.50168841
6NEK13.26667817
7CASK2.95586687
8PTK2B2.38944233
9PRKD32.32588422
10TESK12.20849526
11PLK42.19518178
12MAPK152.00248197
13STK391.92020760
14EPHA41.91496873
15WNK41.79782027
16MAP2K71.74271564
17MAP3K41.73033014
18CCNB11.70121768
19NTRK31.57809527
20NUAK11.54441743
21TIE11.53303872
22MAP3K121.42854252
23DYRK21.39712056
24BRSK21.38105418
25ZAK1.35638103
26ICK1.35459024
27PLK21.35059311
28MAP4K21.33078192
29EPHA31.30140083
30NTRK21.24517767
31STK381.18185505
32ARAF1.13648085
33TTK1.13461574
34MET1.12282848
35CDK191.07428165
36TLK11.06499499
37DYRK31.02662407
38ACVR1B1.02421655
39RIPK41.01443245
40MINK10.99323697
41MAP3K90.97871282
42MAP2K40.95516170
43OXSR10.95452791
44EPHA20.94644883
45ERBB20.93699044
46PDK10.91256688
47DAPK20.91251036
48PRKCG0.89293444
49CDC70.86039511
50STK240.85285104
51CSK0.83248659
52CSNK1G20.81612042
53ERBB30.81204709
54TYRO30.78154764
55IRAK10.77683694
56BRAF0.76734299
57CAMK2A0.75448138
58GRK50.74846155
59VRK10.73536968
60DAPK10.73534464
61ADRBK10.70631235
62PINK10.70367446
63WNK10.69728652
64IRAK20.68874147
65PAK60.68668476
66INSRR0.68476335
67DYRK1B0.67988740
68UHMK10.67832790
69MAP3K20.67198718
70LATS10.65725287
71MARK10.64992833
72PLK10.64806269
73STK30.60087660
74BMPR20.58677862
75CAMKK10.58654385
76LMTK20.58032639
77ROCK20.57074857
78AKT30.55208309
79CDK50.54118391
80VRK20.53626179
81AURKA0.52825485
82TEC0.52108135
83CAMK1G0.52009109
84CAMK2B0.50614020
85BMPR1B0.50075865
86SGK10.49875272
87CAMKK20.49583571
88TNIK0.48456178
89MAPK130.48018292
90ROCK10.45715077
91PDPK10.45697301
92CAMK1D0.44717328
93NEK60.43943480
94YES10.43204947
95LRRK20.42232081
96NME10.42154197
97TAF10.42024837
98WNK30.41410747
99DMPK0.41089498
100CAMK40.40183040
101CDK30.39375309
102MAP3K110.39228173
103PRKCI0.39070786
104MARK20.38859484
105MAPKAPK50.38436029
106TYK20.35467834
107CDK180.35394552
108STK110.34500598
109PRKG10.32932987
110ADRBK20.31890775
111CDK150.31335473
112MUSK0.29851943
113GRK70.28926070
114FES0.28513681
115CDK140.28358568
116FER0.28009004
117MAP3K60.26573545
118FRK0.26520299
119BCR0.26504134
120CDK11A0.24126252
121DYRK1A0.23954110
122NEK20.23816030
123PRKACA0.23433145
124STK38L0.23058917
125PAK30.22513958
126CAMK2D0.22453526
127PRKCQ0.22307913
128PRKCE0.21997152
129SGK4940.21248135
130SGK2230.21248135
131CHEK20.20989855
132GRK10.20810633
133RPS6KA30.18943144
134FGR0.17273520
135CAMK2G0.17151861
136RAF10.16781615
137RPS6KA20.16612629
138WEE10.16416947
139PLK30.16372187
140PRKCA0.16189704
141NTRK10.16188713
142PHKG10.15754375
143PHKG20.15754375
144SGK20.15332163
145PRKACB0.14954676
146CAMK10.14051257
147KSR10.13529192
148MYLK0.13444959

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.30001363
2Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.98015691
3Vitamin B6 metabolism_Homo sapiens_hsa007502.92575948
4Synaptic vesicle cycle_Homo sapiens_hsa047212.90575057
5Amphetamine addiction_Homo sapiens_hsa050312.89226269
6Collecting duct acid secretion_Homo sapiens_hsa049662.88618441
7Olfactory transduction_Homo sapiens_hsa047402.83797646
8Pyruvate metabolism_Homo sapiens_hsa006202.78032416
9Chemical carcinogenesis_Homo sapiens_hsa052042.47976116
10Long-term potentiation_Homo sapiens_hsa047202.25540531
11Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.22171200
12Histidine metabolism_Homo sapiens_hsa003402.18654499
13Huntingtons disease_Homo sapiens_hsa050162.18578179
14Renin secretion_Homo sapiens_hsa049242.14927493
15Circadian entrainment_Homo sapiens_hsa047132.04576282
16Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.98332834
17Glucagon signaling pathway_Homo sapiens_hsa049221.92769283
18Basal cell carcinoma_Homo sapiens_hsa052171.89788035
19Glutathione metabolism_Homo sapiens_hsa004801.88828741
20Morphine addiction_Homo sapiens_hsa050321.88565514
21Taste transduction_Homo sapiens_hsa047421.86827828
22Glutamatergic synapse_Homo sapiens_hsa047241.86352707
23Salivary secretion_Homo sapiens_hsa049701.75774483
24Insulin secretion_Homo sapiens_hsa049111.74478175
25Calcium signaling pathway_Homo sapiens_hsa040201.69357951
26Dopaminergic synapse_Homo sapiens_hsa047281.66307840
27Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.66057427
28Propanoate metabolism_Homo sapiens_hsa006401.63268503
29GABAergic synapse_Homo sapiens_hsa047271.63012346
30Oxidative phosphorylation_Homo sapiens_hsa001901.62143052
31Tyrosine metabolism_Homo sapiens_hsa003501.60449946
32Phenylalanine metabolism_Homo sapiens_hsa003601.58464102
33Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.55373001
34Peroxisome_Homo sapiens_hsa041461.53549562
35Gastric acid secretion_Homo sapiens_hsa049711.53404896
36Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.52823208
37Cardiac muscle contraction_Homo sapiens_hsa042601.51762885
38Oocyte meiosis_Homo sapiens_hsa041141.50807954
39beta-Alanine metabolism_Homo sapiens_hsa004101.48047206
40Vibrio cholerae infection_Homo sapiens_hsa051101.46545501
41Dorso-ventral axis formation_Homo sapiens_hsa043201.42149401
42Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.41979340
43Cocaine addiction_Homo sapiens_hsa050301.38540092
44Primary bile acid biosynthesis_Homo sapiens_hsa001201.35982698
45Fatty acid biosynthesis_Homo sapiens_hsa000611.35004670
46Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.23929528
47Basal transcription factors_Homo sapiens_hsa030221.20116569
48Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.18479704
49Alzheimers disease_Homo sapiens_hsa050101.17739774
50Serotonergic synapse_Homo sapiens_hsa047261.14139480
51Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.13515236
52Oxytocin signaling pathway_Homo sapiens_hsa049211.12576185
53Estrogen signaling pathway_Homo sapiens_hsa049151.12286928
54Phototransduction_Homo sapiens_hsa047441.12042107
55cGMP-PKG signaling pathway_Homo sapiens_hsa040221.11810484
56Arachidonic acid metabolism_Homo sapiens_hsa005901.11325096
57Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.07541127
58cAMP signaling pathway_Homo sapiens_hsa040241.07204230
59Aldosterone synthesis and secretion_Homo sapiens_hsa049251.05931077
60Retinol metabolism_Homo sapiens_hsa008301.05396943
61Parkinsons disease_Homo sapiens_hsa050121.04695645
62Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.02637995
63Nitrogen metabolism_Homo sapiens_hsa009101.02262976
64Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.98244076
65Phosphatidylinositol signaling system_Homo sapiens_hsa040700.95146944
66Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.94495940
67Cholinergic synapse_Homo sapiens_hsa047250.91181950
68Glycerolipid metabolism_Homo sapiens_hsa005610.87900951
69Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.87649505
70Steroid biosynthesis_Homo sapiens_hsa001000.87237574
71Regulation of autophagy_Homo sapiens_hsa041400.84717852
72Circadian rhythm_Homo sapiens_hsa047100.84198684
73Hippo signaling pathway_Homo sapiens_hsa043900.82835046
74Vascular smooth muscle contraction_Homo sapiens_hsa042700.82514008
75Linoleic acid metabolism_Homo sapiens_hsa005910.82384416
76Ether lipid metabolism_Homo sapiens_hsa005650.81596090
77ABC transporters_Homo sapiens_hsa020100.79886817
78Long-term depression_Homo sapiens_hsa047300.78771257
79alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.78230396
80Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.78226222
81Thyroid hormone synthesis_Homo sapiens_hsa049180.78220213
82Tryptophan metabolism_Homo sapiens_hsa003800.77950794
83Glycerophospholipid metabolism_Homo sapiens_hsa005640.75265878
84Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.74574619
85Pancreatic secretion_Homo sapiens_hsa049720.74201471
86Carbohydrate digestion and absorption_Homo sapiens_hsa049730.74153189
87Rheumatoid arthritis_Homo sapiens_hsa053230.72924552
88Tight junction_Homo sapiens_hsa045300.71797099
89Homologous recombination_Homo sapiens_hsa034400.70345741
90Steroid hormone biosynthesis_Homo sapiens_hsa001400.69845154
91Cysteine and methionine metabolism_Homo sapiens_hsa002700.69408209
92Mineral absorption_Homo sapiens_hsa049780.69116630
93Pentose phosphate pathway_Homo sapiens_hsa000300.68901875
94Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.67577571
95SNARE interactions in vesicular transport_Homo sapiens_hsa041300.66666298
96Inositol phosphate metabolism_Homo sapiens_hsa005620.66457012
97Protein export_Homo sapiens_hsa030600.65223330
98Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.64855130
99Gap junction_Homo sapiens_hsa045400.63341670
100Glycosaminoglycan degradation_Homo sapiens_hsa005310.61430308
101Purine metabolism_Homo sapiens_hsa002300.61024230
102Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.60913755
103Notch signaling pathway_Homo sapiens_hsa043300.60175358
104Axon guidance_Homo sapiens_hsa043600.59523670
105Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.55495760
106Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.55492107
107Sphingolipid metabolism_Homo sapiens_hsa006000.55212140
108Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.54924889
109Fatty acid degradation_Homo sapiens_hsa000710.54634600
110Carbon metabolism_Homo sapiens_hsa012000.51323227
111Fanconi anemia pathway_Homo sapiens_hsa034600.50996185
112Caffeine metabolism_Homo sapiens_hsa002320.49107640
113Wnt signaling pathway_Homo sapiens_hsa043100.48126837
114Melanogenesis_Homo sapiens_hsa049160.47765977
115GnRH signaling pathway_Homo sapiens_hsa049120.45534242
116Phagosome_Homo sapiens_hsa041450.44884232
117Ovarian steroidogenesis_Homo sapiens_hsa049130.44157902
118Systemic lupus erythematosus_Homo sapiens_hsa053220.42860170
119Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.42228842
120Rap1 signaling pathway_Homo sapiens_hsa040150.41462358
121Adherens junction_Homo sapiens_hsa045200.41012472
122Alcoholism_Homo sapiens_hsa050340.39777539
123Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.39389752
124Fructose and mannose metabolism_Homo sapiens_hsa000510.38209793
125PPAR signaling pathway_Homo sapiens_hsa033200.36738596
126Type II diabetes mellitus_Homo sapiens_hsa049300.36630315
127MAPK signaling pathway_Homo sapiens_hsa040100.35557982
128Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.34845071
129Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.33869649
130Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.33716175
131Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.29855366
132Bile secretion_Homo sapiens_hsa049760.29035945
133Sulfur metabolism_Homo sapiens_hsa009200.28796060
134Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.28656521
135Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.27824886
136Hedgehog signaling pathway_Homo sapiens_hsa043400.27048144
137Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.24931841
138Ras signaling pathway_Homo sapiens_hsa040140.24013680
139Metabolic pathways_Homo sapiens_hsa011000.22836583
140VEGF signaling pathway_Homo sapiens_hsa043700.20913905

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