LRRC61

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axonemal dynein complex assembly (GO:0070286)7.82547826
2cilium movement (GO:0003341)7.45284679
3amyloid precursor protein catabolic process (GO:0042987)7.26178665
4epithelial cilium movement (GO:0003351)7.17986028
5cilium or flagellum-dependent cell motility (GO:0001539)6.85203825
6deoxyribonucleoside monophosphate metabolic process (GO:0009162)6.09702081
7response to pheromone (GO:0019236)5.83359816
8motile cilium assembly (GO:0044458)5.83287866
9response to parathyroid hormone (GO:0071107)5.80753293
10peptidyl-arginine omega-N-methylation (GO:0035247)5.58328607
11muscle cell fate commitment (GO:0042693)5.56469989
12epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.49007269
13sperm motility (GO:0030317)5.45531535
14acrosome reaction (GO:0007340)5.29651206
15axoneme assembly (GO:0035082)5.19593516
16oxidative phosphorylation (GO:0006119)5.17919930
17piRNA metabolic process (GO:0034587)5.09261405
18amyloid precursor protein metabolic process (GO:0042982)5.05282760
19muscle organ morphogenesis (GO:0048644)4.90615155
20histone arginine methylation (GO:0034969)4.84439708
21ventricular system development (GO:0021591)4.81148213
22pentose metabolic process (GO:0019321)4.74467543
23peptidyl-arginine methylation (GO:0018216)4.64409029
24peptidyl-arginine N-methylation (GO:0035246)4.64409029
25regulation of cilium movement (GO:0003352)4.34292311
26rRNA transcription (GO:0009303)4.33688555
27proline biosynthetic process (GO:0006561)4.24125649
28substrate-independent telencephalic tangential migration (GO:0021826)3.95281773
29substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.95281773
30pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.81809481
31response to lead ion (GO:0010288)3.74376003
32tooth mineralization (GO:0034505)3.73848279
33phosphate ion homeostasis (GO:0055062)3.71294035
34trivalent inorganic anion homeostasis (GO:0072506)3.71294035
35peptidyl-histidine modification (GO:0018202)3.66395771
36membrane repolarization during action potential (GO:0086011)3.63953572
37acrosome assembly (GO:0001675)3.63405480
38negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.60914777
39GDP-mannose metabolic process (GO:0019673)3.60248640
40vocalization behavior (GO:0071625)3.58521462
41coronary vasculature morphogenesis (GO:0060977)3.55824738
42pyrimidine nucleobase catabolic process (GO:0006208)3.53873219
43sperm-egg recognition (GO:0035036)3.50515088
44left/right pattern formation (GO:0060972)3.47330611
45embryonic viscerocranium morphogenesis (GO:0048703)3.45923403
46lymph vessel development (GO:0001945)3.45617752
47outflow tract septum morphogenesis (GO:0003148)3.40632463
48cellular anion homeostasis (GO:0030002)3.40039097
49regulation of secondary heart field cardioblast proliferation (GO:0003266)3.35927763
50regulation of cardioblast proliferation (GO:0003264)3.35927763
51fusion of sperm to egg plasma membrane (GO:0007342)3.33480778
52pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.32697652
53ribosomal small subunit biogenesis (GO:0042274)3.31082187
54binding of sperm to zona pellucida (GO:0007339)3.28312118
55iron-sulfur cluster assembly (GO:0016226)3.28292960
56metallo-sulfur cluster assembly (GO:0031163)3.28292960
57male meiosis (GO:0007140)3.27281425
58regulation of mammary gland epithelial cell proliferation (GO:0033599)3.26947547
59multicellular organism reproduction (GO:0032504)3.26898371
60outer ear morphogenesis (GO:0042473)3.23592774
61DNA strand elongation involved in DNA replication (GO:0006271)3.23479475
62spermatid development (GO:0007286)3.22902868
63regulation of mitochondrial translation (GO:0070129)3.21343751
64cell-cell recognition (GO:0009988)3.20691118
65skin morphogenesis (GO:0043589)3.18240289
66proline metabolic process (GO:0006560)3.17062721
67mitotic G1 DNA damage checkpoint (GO:0031571)3.15528056
68DNA strand elongation (GO:0022616)3.14868830
69dorsal/ventral neural tube patterning (GO:0021904)3.14312508
70RNA localization (GO:0006403)3.13222307
71negative regulation of inclusion body assembly (GO:0090084)3.13141723
72erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.12917369
73L-phenylalanine metabolic process (GO:0006558)3.12917369
74regulation of translational fidelity (GO:0006450)3.09919007
75apoptotic process involved in morphogenesis (GO:0060561)3.09863040
76pyrimidine nucleotide catabolic process (GO:0006244)3.09099356
77protein insertion into membrane (GO:0051205)3.08107285
78DNA replication initiation (GO:0006270)3.06065001
79calcium ion-dependent exocytosis (GO:0017156)3.05717893
80telomere maintenance via semi-conservative replication (GO:0032201)3.05701548
81positive thymic T cell selection (GO:0045059)3.04419686
82NADP metabolic process (GO:0006739)3.02653290
83urinary tract smooth muscle contraction (GO:0014848)3.02652093
84L-serine metabolic process (GO:0006563)3.02588527
85pharyngeal system development (GO:0060037)3.01010099
86DNA methylation involved in gamete generation (GO:0043046)3.00937942
87thyroid gland development (GO:0030878)3.00579320
88retinoic acid receptor signaling pathway (GO:0048384)2.98422286
89viral transcription (GO:0019083)2.97531603
90regulation of cardioblast differentiation (GO:0051890)2.95402227
91protein maturation by protein folding (GO:0022417)2.95259500
92gamma-aminobutyric acid transport (GO:0015812)2.94020565
93membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.93549645
94synaptic vesicle maturation (GO:0016188)2.91466813
95kinetochore assembly (GO:0051382)2.90601202
96base-excision repair (GO:0006284)2.90545468
97positive regulation of CREB transcription factor activity (GO:0032793)2.89883478
98pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.88988247
99cranial nerve morphogenesis (GO:0021602)2.88026438
100reproduction (GO:0000003)2.87929094
101positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.87543973
102pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.87483450
103DNA unwinding involved in DNA replication (GO:0006268)2.85997229
104peptidyl-arginine modification (GO:0018195)2.85888059
105regulation of cytokine production involved in inflammatory response (GO:1900015)2.85548158
106protein complex biogenesis (GO:0070271)2.85239228
107protein autoprocessing (GO:0016540)2.84879721
108folic acid metabolic process (GO:0046655)2.84785628
109cilium morphogenesis (GO:0060271)2.84778974
110left/right axis specification (GO:0070986)2.84592033
111membrane protein intracellular domain proteolysis (GO:0031293)2.83341652
112sulfur amino acid catabolic process (GO:0000098)2.82239605
113cilium organization (GO:0044782)2.80635389
114nucleobase-containing small molecule interconversion (GO:0015949)2.77578488
115negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.76113983
116negative regulation of translation, ncRNA-mediated (GO:0040033)2.76113983
117regulation of translation, ncRNA-mediated (GO:0045974)2.76113983
118pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.75918663
119atrial septum morphogenesis (GO:0060413)2.75653204
120spliceosomal tri-snRNP complex assembly (GO:0000244)2.75595078
121protein polyglutamylation (GO:0018095)2.74717401
122mitochondrial fusion (GO:0008053)2.73551761
123protein retention in ER lumen (GO:0006621)2.73453264
124translational termination (GO:0006415)2.72259722
125cilium assembly (GO:0042384)2.72072765
126ATP biosynthetic process (GO:0006754)2.71768828
127UTP biosynthetic process (GO:0006228)2.71277508
128ribonucleoside triphosphate biosynthetic process (GO:0009201)2.70848678
129regulation of microtubule-based movement (GO:0060632)2.70256730
130nucleobase catabolic process (GO:0046113)2.69620965
131pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.68906141
132response to lipoprotein particle (GO:0055094)2.68481750
133translational elongation (GO:0006414)2.67769724
134guanosine-containing compound biosynthetic process (GO:1901070)2.67135989
135plasma membrane fusion (GO:0045026)2.67104310
136nucleoside transmembrane transport (GO:1901642)2.66866338
137calcium ion import (GO:0070509)2.66150054
138positive regulation of amino acid transport (GO:0051957)2.65417269
139purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.65402065
140G1 DNA damage checkpoint (GO:0044783)2.65228409
141mitochondrial respiratory chain complex assembly (GO:0033108)2.64944484
142response to acidic pH (GO:0010447)2.64899098
143positive T cell selection (GO:0043368)2.64772628
144positive regulation of cellular amine metabolic process (GO:0033240)2.64076175
145mitotic G1/S transition checkpoint (GO:0044819)2.63925401
146organic cation transport (GO:0015695)2.63525733
147synaptonemal complex organization (GO:0070193)2.63231918
148axon ensheathment in central nervous system (GO:0032291)2.62972196
149central nervous system myelination (GO:0022010)2.62972196
150purine nucleoside triphosphate biosynthetic process (GO:0009145)2.62884135
151spermatogenesis (GO:0007283)2.62376461
152DNA strand renaturation (GO:0000733)2.61611293
153microtubule severing (GO:0051013)2.60876089
154deoxyribonucleotide catabolic process (GO:0009264)2.60363779
155male gamete generation (GO:0048232)2.59870831
156negative regulation of microtubule polymerization (GO:0031115)2.59761040
157negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.59291047
158single fertilization (GO:0007338)2.59063150
159response to vitamin D (GO:0033280)2.58626874
160response to auditory stimulus (GO:0010996)2.58582344
161synaptic vesicle docking involved in exocytosis (GO:0016081)2.57447195
162intraciliary transport (GO:0042073)2.56991845
163positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.56876390
164astrocyte differentiation (GO:0048708)2.55149764
165detection of light stimulus involved in sensory perception (GO:0050962)2.51922816
166detection of light stimulus involved in visual perception (GO:0050908)2.51922816
167cAMP catabolic process (GO:0006198)2.51785652
168regulation of short-term neuronal synaptic plasticity (GO:0048172)2.50893838
169nucleoside diphosphate phosphorylation (GO:0006165)2.50750982
170negative regulation of skeletal muscle tissue development (GO:0048642)2.49982699
171female mating behavior (GO:0060180)2.47040898
172peptidyl-glutamic acid modification (GO:0018200)2.46779875
173cellular component assembly involved in morphogenesis (GO:0010927)2.44319741
174sperm capacitation (GO:0048240)2.43918098
175regulation of protein kinase C signaling (GO:0090036)2.40416639
176fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.40361118
177regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.38972066
178gamete generation (GO:0007276)2.38331540
179oxidative demethylation (GO:0070989)2.34998360
180regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.31286894
181regulation of female receptivity (GO:0045924)2.28723650
182microtubule-based movement (GO:0007018)2.28315589
183nonmotile primary cilium assembly (GO:0035058)2.26914564
184auditory behavior (GO:0031223)2.25791549
185protein localization to cilium (GO:0061512)2.24553803
186cyclic nucleotide catabolic process (GO:0009214)2.23880237
187phosphorelay signal transduction system (GO:0000160)2.23354304
188regulation of inclusion body assembly (GO:0090083)2.23192120
189cell recognition (GO:0008037)2.21218780
190eye photoreceptor cell differentiation (GO:0001754)2.21030930
191photoreceptor cell differentiation (GO:0046530)2.21030930
192regulation of neuronal synaptic plasticity (GO:0048168)2.20994456
193negative regulation of organelle assembly (GO:1902116)2.19396866
194positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.18878097
195glucosamine-containing compound catabolic process (GO:1901072)2.18864443
196lung epithelium development (GO:0060428)2.18187571
197protein-DNA complex disassembly (GO:0032986)2.16775168

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.31885876
2EZH2_22144423_ChIP-Seq_EOC_Human4.84377326
3HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.17162935
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.12147720
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.09470120
6E2F7_22180533_ChIP-Seq_HELA_Human2.80490831
7MYC_18555785_ChIP-Seq_MESCs_Mouse2.72278295
8* MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.60186052
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.44914397
10MYC_18358816_ChIP-ChIP_MESCs_Mouse2.43485417
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.32139809
12TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.30069419
13THAP11_20581084_ChIP-Seq_MESCs_Mouse2.23182519
14DROSHA_22980978_ChIP-Seq_HELA_Human2.15918200
15VDR_21846776_ChIP-Seq_THP-1_Human2.14773518
16LXR_22292898_ChIP-Seq_THP-1_Human2.14098484
17TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.12604712
18MYC_22102868_ChIP-Seq_BL_Human2.10182514
19GBX2_23144817_ChIP-Seq_PC3_Human2.09393051
20XRN2_22483619_ChIP-Seq_HELA_Human2.05753809
21SUZ12_27294783_Chip-Seq_ESCs_Mouse2.04276033
22EZH2_27294783_Chip-Seq_ESCs_Mouse2.02578092
23PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.00778785
24IKZF1_21737484_ChIP-ChIP_HCT116_Human2.00311273
25SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.97070011
26TET1_21451524_ChIP-Seq_MESCs_Mouse1.94386871
27CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.93129579
28ZNF263_19887448_ChIP-Seq_K562_Human1.89324279
29ETS1_20019798_ChIP-Seq_JURKAT_Human1.86185027
30DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.85799424
31SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.84566978
32* REST_21632747_ChIP-Seq_MESCs_Mouse1.84372597
33ELF1_17652178_ChIP-ChIP_JURKAT_Human1.81389591
34MYC_19079543_ChIP-ChIP_MESCs_Mouse1.78547725
35SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.78428961
36MYC_19030024_ChIP-ChIP_MESCs_Mouse1.77291466
37RNF2_27304074_Chip-Seq_ESCs_Mouse1.75726712
38GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.74162005
39RACK7_27058665_Chip-Seq_MCF-7_Human1.73334178
40MTF2_20144788_ChIP-Seq_MESCs_Mouse1.72297189
41SRY_22984422_ChIP-ChIP_TESTIS_Rat1.69803296
42DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.66912806
43GABP_19822575_ChIP-Seq_HepG2_Human1.65290578
44YY1_21170310_ChIP-Seq_MESCs_Mouse1.64841472
45RNF2_18974828_ChIP-Seq_MESCs_Mouse1.63568124
46EZH2_18974828_ChIP-Seq_MESCs_Mouse1.63568124
47JARID2_20064375_ChIP-Seq_MESCs_Mouse1.61957260
48SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.60651711
49P68_20966046_ChIP-Seq_HELA_Human1.60011555
50* CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.57451043
51EZH2_27304074_Chip-Seq_ESCs_Mouse1.54594128
52JARID2_20075857_ChIP-Seq_MESCs_Mouse1.54455796
53EED_16625203_ChIP-ChIP_MESCs_Mouse1.54284787
54CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.54100746
55SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.52720570
56* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.52360750
57SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.52274854
58DCP1A_22483619_ChIP-Seq_HELA_Human1.50969884
59RARB_27405468_Chip-Seq_BRAIN_Mouse1.49725870
60ELK3_25401928_ChIP-Seq_HUVEC_Human1.48804126
61ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.48610467
62ELF1_20517297_ChIP-Seq_JURKAT_Human1.47390308
63* CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.45419508
64ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.43712276
65ZFX_18555785_ChIP-Seq_MESCs_Mouse1.41893883
66REST_18959480_ChIP-ChIP_MESCs_Mouse1.41766637
67TP63_17297297_ChIP-ChIP_HaCaT_Human1.41762905
68ELK4_26923725_Chip-Seq_MESODERM_Mouse1.41707943
69PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.41596138
70KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.40693337
71ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.37217731
72* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.37079756
73* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.35586413
74STAT3_1855785_ChIP-Seq_MESCs_Mouse1.35574970
75SA1_27219007_Chip-Seq_ERYTHROID_Human1.33825025
76AR_21572438_ChIP-Seq_LNCaP_Human1.33548331
77CBX2_27304074_Chip-Seq_ESCs_Mouse1.33489751
78CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.32979748
79FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.32588942
80BCL6_27268052_Chip-Seq_Bcells_Human1.32296567
81NANOG_18555785_ChIP-Seq_MESCs_Mouse1.31076939
82CTCF_18555785_ChIP-Seq_MESCs_Mouse1.30365666
83POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.30107468
84NELFA_20434984_ChIP-Seq_ESCs_Mouse1.29817715
85CREB1_15753290_ChIP-ChIP_HEK293T_Human1.29228066
86KDM5A_27292631_Chip-Seq_BREAST_Human1.28398388
87* SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.27570046
88CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.26708766
89SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.25891042
90* NCOR1_26117541_ChIP-Seq_K562_Human1.25169216
91* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.24170397
92FOXP1_21924763_ChIP-Seq_HESCs_Human1.24152247
93TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.22344426
94EST1_17652178_ChIP-ChIP_JURKAT_Human1.21005891
95RING1B_27294783_Chip-Seq_ESCs_Mouse1.20652043
96* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.20373034
97BCOR_27268052_Chip-Seq_Bcells_Human1.19445123
98NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.18956631
99CTCF_21964334_Chip-Seq_Bcells_Human1.17523550
100ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.17454681
101* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.16848188
102PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.16747185
103SRF_21415370_ChIP-Seq_HL-1_Mouse1.16672890
104PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.16449741
105RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.16059991
106CTCF_27219007_Chip-Seq_ERYTHROID_Human1.14544842
107SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.14255697
108CTCF_26484167_Chip-Seq_Bcells_Mouse1.14131931
109CIITA_25753668_ChIP-Seq_RAJI_Human1.13875088
110CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.13828396
111VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.13602735
112KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.13466296
113SMAD4_21799915_ChIP-Seq_A2780_Human1.12978506
114MAF_26560356_Chip-Seq_TH1_Human1.11283087
115MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.10522560
116CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.10003075
117WDR5_24793694_ChIP-Seq_LNCAP_Human1.09488005
118CTBP2_25329375_ChIP-Seq_LNCAP_Human1.08982232
119RARA_24833708_ChIP-Seq_LIVER_Mouse1.08635170
120ZFP57_27257070_Chip-Seq_ESCs_Mouse1.08555492
121* TTF2_22483619_ChIP-Seq_HELA_Human1.08372797
122SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.08240128
123YY1_22570637_ChIP-Seq_MALME-3M_Human1.08151322
124TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08132554
125CTBP1_25329375_ChIP-Seq_LNCAP_Human1.08107276
126MAF_26560356_Chip-Seq_TH2_Human1.07717642
127NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.07611114
128NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.07374623
129SMAD_19615063_ChIP-ChIP_OVARY_Human1.07260018
130KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.06719442
131EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.06571757
132GATA1_26923725_Chip-Seq_HPCs_Mouse1.06547426
133PPARA_22158963_ChIP-Seq_LIVER_Mouse1.06268626
134EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.05659812
135SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.05539540
136FOXP3_21729870_ChIP-Seq_TREG_Human1.04632021
137CTCF_27219007_Chip-Seq_Bcells_Human1.04208267
138E2F1_20622854_ChIP-Seq_HELA_Human1.03383958
139PHF8_20622854_ChIP-Seq_HELA_Human1.03229313
140CREB1_26743006_Chip-Seq_LNCaP_Human1.02972457
141POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.02728153
142THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.02505240
143CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.02497090
144KDM2B_26808549_Chip-Seq_SUP-B15_Human1.01597376
145SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.01303302
146P53_22127205_ChIP-Seq_FIBROBLAST_Human1.00670615
147* SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.00407630
148TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00342382
149POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.00342382
150TAF15_26573619_Chip-Seq_HEK293_Human0.99455512
151* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.99439472
152UTX_26944678_Chip-Seq_JUKART_Human0.99403608
153SUZ12_27294783_Chip-Seq_NPCs_Mouse0.99297551
154RNF2_27304074_Chip-Seq_NSC_Mouse0.98121361
155IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.97429720
156CBP_20019798_ChIP-Seq_JUKART_Human0.97429720
157WT1_25993318_ChIP-Seq_PODOCYTE_Human0.96690189
158MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.96214678
159MYC_27129775_Chip-Seq_CORNEA_Mouse0.95798148
160NR3C1_21868756_ChIP-Seq_MCF10A_Human0.94410854
161TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.93793162
162NFE2_27457419_Chip-Seq_LIVER_Mouse0.93195151
163PCGF2_27294783_Chip-Seq_NPCs_Mouse0.93184877
164TCF4_23295773_ChIP-Seq_U87_Human0.92953757
165KDM2B_26808549_Chip-Seq_REH_Human0.91722708
166SMC4_20622854_ChIP-Seq_HELA_Human0.91402568
167ZNF274_21170338_ChIP-Seq_K562_Hela0.91331858
168SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.90601849
169TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.89497539
170ER_23166858_ChIP-Seq_MCF-7_Human0.89466064
171AR_25329375_ChIP-Seq_VCAP_Human0.89463076
172BCAT_22108803_ChIP-Seq_LS180_Human0.88404969
173SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.88371085
174AR_19668381_ChIP-Seq_PC3_Human0.87613370
175PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.87599194
176GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86920538
177SMAD4_21741376_ChIP-Seq_HESCs_Human0.85045512
178OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.84541045
179KLF4_19829295_ChIP-Seq_ESCs_Human0.84098216
180PCGF2_27294783_Chip-Seq_ESCs_Mouse0.82885588
181P300_19829295_ChIP-Seq_ESCs_Human0.82684082
182PRDM14_20953172_ChIP-Seq_ESCs_Human0.82677274
183LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82360353
184RING1B_27294783_Chip-Seq_NPCs_Mouse0.81272391
185CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.80482967
186SMAD3_21741376_ChIP-Seq_ESCs_Human0.80370422
187KDM2B_26808549_Chip-Seq_K562_Human0.79760374
188STAT3_23295773_ChIP-Seq_U87_Human0.78260943
189PIAS1_25552417_ChIP-Seq_VCAP_Human0.77986864
190RUNX2_22187159_ChIP-Seq_PCA_Human0.77345176
191EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.76812283
192P53_22387025_ChIP-Seq_ESCs_Mouse0.76363641
193ARNT_22903824_ChIP-Seq_MCF-7_Human0.76339303
194EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.75792747
195OCT4_21477851_ChIP-Seq_ESCs_Mouse0.75171335
196STAT6_21828071_ChIP-Seq_BEAS2B_Human0.75149440
197NANOG_18555785_Chip-Seq_ESCs_Mouse0.74566274

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization5.58789961
2MP0005423_abnormal_somatic_nervous3.35923352
3MP0002653_abnormal_ependyma_morphology3.33586414
4MP0002249_abnormal_larynx_morphology3.23099545
5MP0003195_calcinosis3.10178167
6MP0004859_abnormal_synaptic_plasticity2.75927680
7MP0010030_abnormal_orbit_morphology2.75104330
8MP0003693_abnormal_embryo_hatching2.59586135
9MP0002132_abnormal_respiratory_system2.53413507
10MP0008961_abnormal_basal_metabolism2.52663290
11MP0005646_abnormal_pituitary_gland2.51181803
12MP0009333_abnormal_splenocyte_physiolog2.49385594
13MP0005451_abnormal_body_composition2.46451789
14MP0002822_catalepsy2.43339113
15MP0001984_abnormal_olfaction2.37658392
16MP0002638_abnormal_pupillary_reflex2.28476601
17MP0003698_abnormal_male_reproductive2.26938887
18MP0006276_abnormal_autonomic_nervous2.24871360
19MP0005551_abnormal_eye_electrophysiolog2.18587257
20MP0005367_renal/urinary_system_phenotyp2.12193556
21MP0000516_abnormal_urinary_system2.12193556
22MP0008932_abnormal_embryonic_tissue2.03614092
23MP0004957_abnormal_blastocyst_morpholog2.01218573
24MP0003635_abnormal_synaptic_transmissio1.99120789
25MP0009046_muscle_twitch1.97331350
26MP0005645_abnormal_hypothalamus_physiol1.89352845
27MP0005409_darkened_coat_color1.87981288
28MP0006036_abnormal_mitochondrial_physio1.83672974
29MP0003786_premature_aging1.80195343
30MP0002909_abnormal_adrenal_gland1.79650680
31MP0003111_abnormal_nucleus_morphology1.77587101
32MP0001968_abnormal_touch/_nociception1.75106335
33MP0000681_abnormal_thyroid_gland1.74628294
34MP0002063_abnormal_learning/memory/cond1.73731928
35MP0005670_abnormal_white_adipose1.72587582
36MP0002557_abnormal_social/conspecific_i1.69105324
37MP0002064_seizures1.64226216
38MP0003183_abnormal_peptide_metabolism1.61722790
39MP0000778_abnormal_nervous_system1.60934372
40MP0004270_analgesia1.59818101
41MP0000733_abnormal_muscle_development1.59094002
42MP0001929_abnormal_gametogenesis1.58565013
43MP0008260_abnormal_autophagy1.56774496
44MP0003646_muscle_fatigue1.56202403
45MP0005501_abnormal_skin_physiology1.54862942
46MP0003011_delayed_dark_adaptation1.54034074
47MP0006292_abnormal_olfactory_placode1.53860520
48MP0001486_abnormal_startle_reflex1.53560158
49MP0000049_abnormal_middle_ear1.51774967
50MP0009745_abnormal_behavioral_response1.51054587
51MP0002796_impaired_skin_barrier1.50136634
52MP0002572_abnormal_emotion/affect_behav1.49745917
53MP0008058_abnormal_DNA_repair1.43221136
54MP0002938_white_spotting1.41415019
55MP0009250_abnormal_appendicular_skeleto1.40801737
56MP0005499_abnormal_olfactory_system1.39872679
57MP0005394_taste/olfaction_phenotype1.39872679
58MP0003077_abnormal_cell_cycle1.39298907
59MP0010094_abnormal_chromosome_stability1.36205690
60MP0003806_abnormal_nucleotide_metabolis1.33933273
61MP0003303_peritoneal_inflammation1.29490211
62MP0000631_abnormal_neuroendocrine_gland1.28172064
63MP0008875_abnormal_xenobiotic_pharmacok1.28055855
64MP0001502_abnormal_circadian_rhythm1.27836941
65MP0004811_abnormal_neuron_physiology1.26879351
66MP0002736_abnormal_nociception_after1.26467992
67MP0002139_abnormal_hepatobiliary_system1.26020773
68MP0003880_abnormal_central_pattern1.25998580
69MP0000015_abnormal_ear_pigmentation1.20734720
70MP0008789_abnormal_olfactory_epithelium1.20010529
71MP0001661_extended_life_span1.18996573
72MP0001986_abnormal_taste_sensitivity1.17134694
73MP0002282_abnormal_trachea_morphology1.15344128
74MP0010386_abnormal_urinary_bladder1.15123359
75MP0002161_abnormal_fertility/fecundity1.14568771
76MP0004130_abnormal_muscle_cell1.14387711
77MP0003186_abnormal_redox_activity1.12512470
78MP0001270_distended_abdomen1.12410631
79MP0002163_abnormal_gland_morphology1.11510831
80MP0002734_abnormal_mechanical_nocicepti1.11076894
81MP0001958_emphysema1.10830009
82MP0002932_abnormal_joint_morphology1.09968184
83MP0001501_abnormal_sleep_pattern1.08933861
84MP0006035_abnormal_mitochondrial_morpho1.07392835
85MP0000955_abnormal_spinal_cord1.07049487
86MP0000566_synostosis1.06565503
87MP0005636_abnormal_mineral_homeostasis1.06324580
88MP0001346_abnormal_lacrimal_gland1.06169828
89MP0005332_abnormal_amino_acid1.05933847
90MP0001730_embryonic_growth_arrest1.05449914
91MP0000703_abnormal_thymus_morphology1.04861618
92MP0001188_hyperpigmentation1.04718975
93MP0000313_abnormal_cell_death1.04432806
94MP0008004_abnormal_stomach_pH1.03177263
95MP0002234_abnormal_pharynx_morphology1.02856335
96MP0002837_dystrophic_cardiac_calcinosis1.02629907
97MP0003122_maternal_imprinting1.02023164
98MP0002277_abnormal_respiratory_mucosa1.01765882
99MP0002882_abnormal_neuron_morphology1.01083558
100MP0003879_abnormal_hair_cell1.00996871
101MP0009643_abnormal_urine_homeostasis1.00632757
102MP0002272_abnormal_nervous_system0.99216109
103MP0002152_abnormal_brain_morphology0.99183769
104MP0005666_abnormal_adipose_tissue0.99004316
105MP0002210_abnormal_sex_determination0.97977496
106MP0003329_amyloid_beta_deposits0.97718907
107MP0001970_abnormal_pain_threshold0.97565164
108MP0002184_abnormal_innervation0.96957660
109MP0000350_abnormal_cell_proliferation0.95421124
110MP0002102_abnormal_ear_morphology0.94904199
111MP0008438_abnormal_cutaneous_collagen0.94304197
112MP0002067_abnormal_sensory_capabilities0.93270167
113MP0000538_abnormal_urinary_bladder0.93261860
114MP0004264_abnormal_extraembryonic_tissu0.92712318
115MP0009840_abnormal_foam_cell0.92661904
116MP0001873_stomach_inflammation0.92370072
117MP0005058_abnormal_lysosome_morphology0.91676984
118MP0005595_abnormal_vascular_smooth0.91433326
119MP0005253_abnormal_eye_physiology0.90840515
120MP0002971_abnormal_brown_adipose0.90252962
121MP0000678_abnormal_parathyroid_gland0.89650014
122MP0002735_abnormal_chemical_nociception0.86046755
123MP0004185_abnormal_adipocyte_glucose0.85676055
124MP0001440_abnormal_grooming_behavior0.85324940
125MP0004043_abnormal_pH_regulation0.83578171
126MP0002138_abnormal_hepatobiliary_system0.83464066
127MP0005083_abnormal_biliary_tract0.82369083
128MP0003724_increased_susceptibility_to0.82265604
129MP0003633_abnormal_nervous_system0.80688283
130MP0008569_lethality_at_weaning0.80305618
131MP0001764_abnormal_homeostasis0.79818297
132MP0002069_abnormal_eating/drinking_beha0.79803031
133MP0000358_abnormal_cell_content/0.78463283
134MP0005380_embryogenesis_phenotype0.78334751
135MP0001672_abnormal_embryogenesis/_devel0.78334751
136MP0001765_abnormal_ion_homeostasis0.78146782
137MP0002080_prenatal_lethality0.77862307
138MP0002066_abnormal_motor_capabilities/c0.77351343
139MP0005375_adipose_tissue_phenotype0.77079316
140MP0002089_abnormal_postnatal_growth/wei0.75603992
141MP0001849_ear_inflammation0.75542044
142MP0005365_abnormal_bile_salt0.74688077
143MP0001697_abnormal_embryo_size0.74153293
144MP0004019_abnormal_vitamin_homeostasis0.72715531
145MP0003984_embryonic_growth_retardation0.72319897
146MP0004233_abnormal_muscle_weight0.71968763
147MP0000003_abnormal_adipose_tissue0.71852190
148MP0008995_early_reproductive_senescence0.70444160
149MP0009697_abnormal_copulation0.70388586
150MP0003115_abnormal_respiratory_system0.70381024
151MP0002085_abnormal_embryonic_tissue0.70283322
152MP0003656_abnormal_erythrocyte_physiolo0.68061837
153MP0001944_abnormal_pancreas_morphology0.67362229
154MP0003861_abnormal_nervous_system0.66523951
155MP0005248_abnormal_Harderian_gland0.66406748
156MP0004133_heterotaxia0.66270926
157MP0003948_abnormal_gas_homeostasis0.66121005
158MP0002088_abnormal_embryonic_growth/wei0.66064097
159MP0005395_other_phenotype0.65996350
160MP0002108_abnormal_muscle_morphology0.65809066
161MP0001145_abnormal_male_reproductive0.65416666
162MP0005503_abnormal_tendon_morphology0.65192038
163MP0002877_abnormal_melanocyte_morpholog0.65147467
164MP0008874_decreased_physiological_sensi0.65013663
165MP0000762_abnormal_tongue_morphology0.64550306
166MP0000609_abnormal_liver_physiology0.64544327
167MP0004742_abnormal_vestibular_system0.64431606
168MP0003938_abnormal_ear_development0.64161368
169MP0008007_abnormal_cellular_replicative0.64064695
170MP0002177_abnormal_outer_ear0.63019211
171MP0002752_abnormal_somatic_nervous0.62841681
172MP0004782_abnormal_surfactant_physiolog0.62756701
173MP0005195_abnormal_posterior_eye0.62480097
174MP0002396_abnormal_hematopoietic_system0.61906577
175MP0000462_abnormal_digestive_system0.60910057
176MP0003718_maternal_effect0.60541243
177MP0003436_decreased_susceptibility_to0.60053869
178MP0000467_abnormal_esophagus_morphology0.59541711
179MP0003191_abnormal_cellular_cholesterol0.59513844
180MP0002168_other_aberrant_phenotype0.59410853
181MP0005166_decreased_susceptibility_to0.59301760
182MP0000858_altered_metastatic_potential0.58934437
183MP0005220_abnormal_exocrine_pancreas0.58620660
184MP0002019_abnormal_tumor_incidence0.57842371
185MP0002722_abnormal_immune_system0.55977750
186MP0005076_abnormal_cell_differentiation0.54884808
187MP0005508_abnormal_skeleton_morphology0.52305876
188MP0001191_abnormal_skin_condition0.51229955
189MP0000537_abnormal_urethra_morphology0.50372937
190MP0003453_abnormal_keratinocyte_physiol0.50060156

Predicted human phenotypes

RankGene SetZ-score
1Tetany (HP:0001281)9.98523668
2Respiratory insufficiency due to defective ciliary clearance (HP:0200073)9.68509898
3Dynein arm defect of respiratory motile cilia (HP:0012255)8.18688038
4Absent/shortened dynein arms (HP:0200106)8.18688038
5Abnormal respiratory motile cilium physiology (HP:0012261)7.83633044
6Hyperphosphatemia (HP:0002905)7.31205635
7Abnormal respiratory motile cilium morphology (HP:0005938)7.02025845
8Abnormal respiratory epithelium morphology (HP:0012253)7.02025845
9Abnormal ciliary motility (HP:0012262)6.69192269
10Rhinitis (HP:0012384)6.55362040
11Hypoparathyroidism (HP:0000829)5.99596215
12Congenital malformation of the right heart (HP:0011723)5.72540836
13Double outlet right ventricle (HP:0001719)5.72540836
14Chronic bronchitis (HP:0004469)5.47727725
15Truncus arteriosus (HP:0001660)5.11733503
16Microretrognathia (HP:0000308)5.02133386
17Preauricular pit (HP:0004467)4.96548086
18Periauricular skin pits (HP:0100277)4.96548086
19Nasal polyposis (HP:0100582)4.31145036
20Alacrima (HP:0000522)4.26836796
21Abnormality of the nasal mucosa (HP:0000433)3.86517705
22Bronchiectasis (HP:0002110)3.65671768
23Skin pits (HP:0100276)3.37938513
24Recurrent sinusitis (HP:0011108)3.33470002
25Abnormality of the aortic arch (HP:0012303)3.33445891
26Bronchitis (HP:0012387)3.32596784
27Decreased lacrimation (HP:0000633)3.26139592
28Abnormal ventriculo-arterial connection (HP:0011563)3.25842462
29Transposition of the great arteries (HP:0001669)3.25842462
30Abnormal connection of the cardiac segments (HP:0011545)3.25842462
31Hypocalcemia (HP:0002901)3.20575449
32Hypoplastic left heart (HP:0004383)3.17761222
33Chronic sinusitis (HP:0011109)3.15450841
34Abnormality of calcium-phosphate metabolism (HP:0100530)3.03358006
35Seborrheic dermatitis (HP:0001051)2.92368173
36Infertility (HP:0000789)2.88601212
37Hypertensive crisis (HP:0100735)2.84626456
38Cholecystitis (HP:0001082)2.79802312
39Abnormal gallbladder physiology (HP:0012438)2.79802312
40Nephronophthisis (HP:0000090)2.78902038
41Hyperacusis (HP:0010780)2.76352862
42Renovascular hypertension (HP:0100817)2.72685915
43Elfin facies (HP:0004428)2.71210892
44J-shaped sella turcica (HP:0002680)2.70302232
45Ragged-red muscle fibers (HP:0003200)2.62231219
46Nasolacrimal duct obstruction (HP:0000579)2.56996139
47Retinal dysplasia (HP:0007973)2.50612941
48Male infertility (HP:0003251)2.48036511
49Decreased central vision (HP:0007663)2.45909592
50Microvesicular hepatic steatosis (HP:0001414)2.44332343
51Recurrent otitis media (HP:0000403)2.43175118
52Dyschromatopsia (HP:0007641)2.42796398
53Increased muscle lipid content (HP:0009058)2.36351145
54Hypoplastic heart (HP:0001961)2.36233492
55Hypoplasia of the uterus (HP:0000013)2.35901457
56Abnormality of the parathyroid morphology (HP:0011766)2.33999928
57Prostate neoplasm (HP:0100787)2.28770401
58Broad distal phalanx of finger (HP:0009836)2.28393265
59Abnormality of T cell physiology (HP:0011840)2.27822369
60Sclerocornea (HP:0000647)2.26122828
61Abnormality of the tricuspid valve (HP:0001702)2.24953965
62Increased intramyocellular lipid droplets (HP:0012240)2.24293765
63Overriding aorta (HP:0002623)2.23908614
64Megalencephaly (HP:0001355)2.22207495
65Cholelithiasis (HP:0001081)2.21989221
66Severe visual impairment (HP:0001141)2.21260844
67Insomnia (HP:0100785)2.20949290
68Molar tooth sign on MRI (HP:0002419)2.20392916
69Abnormality of midbrain morphology (HP:0002418)2.20392916
70Redundant skin (HP:0001582)2.18560900
71Abnormal mitochondria in muscle tissue (HP:0008316)2.15204873
72Chronic otitis media (HP:0000389)2.15071371
73Conjugated hyperbilirubinemia (HP:0002908)2.14654560
74Obstructive sleep apnea (HP:0002870)2.14039725
75Polydipsia (HP:0001959)2.12172155
76Abnormal drinking behavior (HP:0030082)2.12172155
77Abnormality of dentin (HP:0010299)2.10268324
78Decreased activity of mitochondrial respiratory chain (HP:0008972)2.10250689
79Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.10250689
80Abolished electroretinogram (ERG) (HP:0000550)2.09869018
81Atelectasis (HP:0100750)2.08810244
82Lissencephaly (HP:0001339)2.07799771
83Deep venous thrombosis (HP:0002625)2.06590659
84Central scotoma (HP:0000603)2.06191480
85Recurrent bacterial skin infections (HP:0005406)2.05925750
86Premature skin wrinkling (HP:0100678)2.04686930
87True hermaphroditism (HP:0010459)2.03253094
88Rough bone trabeculation (HP:0100670)2.02919754
89Congenital stationary night blindness (HP:0007642)2.02772203
90Hypokinesia (HP:0002375)2.01611652
91Protrusio acetabuli (HP:0003179)1.96251356
92Focal motor seizures (HP:0011153)1.95489860
93Abnormality of the renal medulla (HP:0100957)1.95448104
94Vacuolated lymphocytes (HP:0001922)1.94794552
95Medial flaring of the eyebrow (HP:0010747)1.94395505
96Metaphyseal irregularity (HP:0003025)1.93434802
97Increased circulating renin level (HP:0000848)1.92780551
98Abnormality of glycolysis (HP:0004366)1.92466387
99Neonatal short-limb short stature (HP:0008921)1.90119009
100Abnormality of the gallbladder (HP:0005264)1.90036315
101Abnormal gallbladder morphology (HP:0012437)1.89861831
102Recurrent bronchitis (HP:0002837)1.89176156
103Renal duplication (HP:0000075)1.88421367
104Congenital hepatic fibrosis (HP:0002612)1.88174873
105Chronic hepatic failure (HP:0100626)1.87220293
106Micronodular cirrhosis (HP:0001413)1.86366507
107Hyperventilation (HP:0002883)1.85946059
108Bony spicule pigmentary retinopathy (HP:0007737)1.85823931
109Anosmia (HP:0000458)1.85136061
110Pancreatic fibrosis (HP:0100732)1.84288448
111Viral hepatitis (HP:0006562)1.84012876
112Hypergonadotropic hypogonadism (HP:0000815)1.82791521
113Rectal prolapse (HP:0002035)1.82439562
114Abnormality of the lacrimal duct (HP:0011481)1.81617824
115Self-mutilation (HP:0000742)1.79979303
116Scotoma (HP:0000575)1.79645141
117Hepatocellular necrosis (HP:0001404)1.79581730
118Progressive muscle weakness (HP:0003323)1.79000367
119Bile duct proliferation (HP:0001408)1.78795927
120Abnormal biliary tract physiology (HP:0012439)1.78795927
121Stridor (HP:0010307)1.78186915
122Flat cornea (HP:0007720)1.77620804
123Choroideremia (HP:0001139)1.77062288
124Villous atrophy (HP:0011473)1.77050611
125Abnormality of small intestinal villus morphology (HP:0011472)1.77050611
126Aplasia/hypoplasia of the uterus (HP:0008684)1.76696423
127Obstructive lung disease (HP:0006536)1.76118010
128Chronic obstructive pulmonary disease (HP:0006510)1.76118010
129Abnormal eating behavior (HP:0100738)1.75553005
130Cerebral palsy (HP:0100021)1.75275782
131Epileptic encephalopathy (HP:0200134)1.74250570
132Hepatocellular carcinoma (HP:0001402)1.73826261
133Progressive cerebellar ataxia (HP:0002073)1.72893930
134Pachygyria (HP:0001302)1.72873848
135Bowel incontinence (HP:0002607)1.72749915
136Polygenic inheritance (HP:0010982)1.72431996
137Abnormal large intestine physiology (HP:0012700)1.72179309
138Abnormality of aromatic amino acid family metabolism (HP:0004338)1.72104871
139Unilateral renal agenesis (HP:0000122)1.71639176
140Abnormally folded helix (HP:0008544)1.70801495
141Bladder diverticulum (HP:0000015)1.70791282
142Tubular atrophy (HP:0000092)1.70394053
143Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.70352817
144Abnormality of monocarboxylic acid metabolism (HP:0010996)1.69738941
145Agammaglobulinemia (HP:0004432)1.68025985
146Focal seizures (HP:0007359)1.67825744
147Gait imbalance (HP:0002141)1.67584241
148Premature rupture of membranes (HP:0001788)1.65978095
149Aplasia/Hypoplasia of the lens (HP:0008063)1.65425282
150Sleep apnea (HP:0010535)1.64381402
151Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.63370370
152Mitochondrial inheritance (HP:0001427)1.63017883
153Birth length less than 3rd percentile (HP:0003561)1.62439074
154Overfolded helix (HP:0000396)1.62093807
155Exotropia (HP:0000577)1.61536265
156Postaxial foot polydactyly (HP:0001830)1.61231185
157Abnormality of molar (HP:0011077)1.60653168
158Abnormality of molar morphology (HP:0011070)1.60653168
159Septate vagina (HP:0001153)1.58870518
160Hepatic necrosis (HP:0002605)1.58766861
161Hyperthyroidism (HP:0000836)1.55729796
162Congenital primary aphakia (HP:0007707)1.55638809
163Neurofibrillary tangles (HP:0002185)1.54077330
164Median cleft lip (HP:0000161)1.53829296
165Visual hallucinations (HP:0002367)1.53776543
166Nephrogenic diabetes insipidus (HP:0009806)1.52001828
167Polyphagia (HP:0002591)1.51307234
168Retinitis pigmentosa (HP:0000510)1.49327966
169Postaxial hand polydactyly (HP:0001162)1.48460118
170Bell-shaped thorax (HP:0001591)1.46740557
171Retinal atrophy (HP:0001105)1.46146377
172Abnormality of macular pigmentation (HP:0008002)1.45447131
173Biconcave vertebral bodies (HP:0004586)1.44951904
174Aplasia/Hypoplasia of the tongue (HP:0010295)1.44627886
175Cystic liver disease (HP:0006706)1.44336262
176Morphological abnormality of the middle ear (HP:0008609)1.44267126
177Abnormality of the diencephalon (HP:0010662)1.43143086
178Polycystic kidney dysplasia (HP:0000113)1.41428103
179Polymicrogyria (HP:0002126)1.40412693
180Polyuria (HP:0000103)1.40239950
181Oculomotor apraxia (HP:0000657)1.40022138
182Patellar dislocation (HP:0002999)1.39626994
183Type II lissencephaly (HP:0007260)1.39514406
184Supranuclear gaze palsy (HP:0000605)1.38494518
185Pancreatic cysts (HP:0001737)1.36679065

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SMG17.37810498
2VRK26.32271366
3PRKD35.38831479
4TAF14.48801699
5MAPK153.09639728
6ICK2.95132326
7TESK12.80896279
8PDK32.79779786
9PDK42.79779786
10DMPK2.76524436
11NME22.73712980
12SIK32.65912801
13EPHA32.64594689
14IRAK32.56461557
15BUB12.21267226
16EPHA22.15585399
17STK162.13161631
18MAP3K31.98558942
19BCKDK1.98438134
20MARK11.95217958
21SIK21.91034352
22NTRK21.88232354
23IRAK11.82841113
24BLK1.80752866
25DAPK11.74512158
26TAOK11.73092918
27YES11.71356500
28TESK21.67793657
29VRK11.62647355
30CASK1.60255948
31PHKG21.58888584
32PHKG11.58888584
33NUAK11.55331048
34MAP2K71.49033481
35FES1.48992596
36MAPKAPK51.40766783
37DYRK1B1.35411665
38GRK11.35132753
39SIK11.34235631
40NTRK31.30867455
41PDK21.28172754
42SGK4941.23917732
43SGK2231.23917732
44MARK21.22007770
45MAPK111.21168912
46STK381.20787187
47CSNK1G31.18970202
48MINK11.18164582
49FGFR41.15933070
50CHEK21.14823814
51TEC1.13629680
52CSNK1A1L1.11757657
53NME11.09385278
54AURKA1.09016383
55MAP3K41.06564194
56WNK41.06365537
57SGK21.04668430
58CDK71.03883316
59KDR1.00617651
60PIM20.98040677
61TTK0.97529050
62SGK30.97149021
63PTK2B0.96812873
64ARAF0.96112301
65MAP3K100.95081958
66MST1R0.91123701
67IRAK20.91093744
68EEF2K0.90988911
69ITK0.90969941
70IRAK40.90291880
71MAP3K80.89378883
72SCYL20.89189865
73WNK10.88692844
74PRKD20.86578407
75CDK80.86559707
76DYRK1A0.86088687
77PAK60.85544022
78MAP3K10.83697721
79FGFR30.82792638
80TAOK20.82485075
81ERN10.79808966
82EIF2AK10.77579838
83RIPK10.77004563
84DAPK30.76579496
85CAMK1G0.75939657
86BRSK10.75005707
87EPHA40.74894221
88RPS6KA20.74787368
89DYRK20.74760554
90FGFR20.74251809
91GRK60.73713137
92CSNK1G10.73492740
93MELK0.72625189
94MAP3K90.72336330
95HIPK20.71824632
96LRRK20.70387047
97MAP3K130.69933893
98CDK120.69535313
99MAP3K110.69468611
100RPS6KB20.68957914
101PRKCH0.68406458
102DAPK20.66795275
103GRK50.64683236
104BRAF0.64604639
105INSRR0.61379477
106CSNK1G20.60902950
107CAMK40.60891613
108JAK10.59721038
109TRIB30.58067288
110MAP2K20.56350317
111CDK50.55853620
112AKT20.55510122
113MST40.55501494
114IKBKE0.55236467
115TYK20.54948931
116TLK10.54938648
117KSR20.54671476
118HCK0.53767200
119CDC70.53601220
120PRKCZ0.53437358
121MAPK40.53229524
122LMTK20.52327896
123TYRO30.51918762
124PRKCI0.51369827
125SRPK10.51105977
126PRKCG0.50544981
127ATR0.49917100
128BTK0.49366881
129PASK0.49099164
130ROCK20.48917345
131CCNB10.48785206
132MAPK120.48377345
133ABL20.47208522
134MAP2K40.46813420
135RIPK40.46072978
136ROCK10.46000143
137PRKG10.45984803
138MAP3K70.44958746
139MAP4K10.44850404
140STK40.44780451
141TGFBR20.44709922
142AURKB0.44544836
143CHEK10.43806140
144PKN10.43253574
145MAP3K20.42527331
146CSK0.42375526
147NEK60.41501060
148BMX0.40184976
149PDPK10.39782969
150EIF2AK20.39720101
151DYRK30.38783075
152PDK10.38637611
153RPS6KA50.38428426
154CDK90.37823208
155KSR10.36640371
156ILK0.36513291
157TXK0.36294788
158MAPK130.36256750
159MTOR0.36196543
160CDK40.35990366
161SYK0.35246891
162SGK10.34944505
163TBK10.34757193
164CAMK2A0.34147017
165RAF10.33963300
166ERBB20.32489264
167ADRBK10.32168191
168PTK60.32154463
169PLK40.31850468
170CAMK1D0.31410316
171FYN0.30974681
172CSNK2A20.30863124
173CDC42BPA0.30347650
174PRKCQ0.29666262
175NEK90.29427955
176MAP3K50.29337448
177PRPF4B0.29216956
178MAP2K30.28167725
179PAK40.23581045
180CDK20.21642827
181CSNK2A10.21506025

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.65615862
2Ribosome_Homo sapiens_hsa030103.10952859
3Base excision repair_Homo sapiens_hsa034102.97508643
4Mismatch repair_Homo sapiens_hsa034302.53140540
5Cysteine and methionine metabolism_Homo sapiens_hsa002702.29456360
6Phototransduction_Homo sapiens_hsa047442.21226581
7Biosynthesis of amino acids_Homo sapiens_hsa012302.19740252
8Nitrogen metabolism_Homo sapiens_hsa009102.18905628
9Olfactory transduction_Homo sapiens_hsa047402.09940231
10Vitamin B6 metabolism_Homo sapiens_hsa007501.99502794
11Fructose and mannose metabolism_Homo sapiens_hsa000511.98682839
12Morphine addiction_Homo sapiens_hsa050321.93425390
13Pentose phosphate pathway_Homo sapiens_hsa000301.89633617
14Sulfur metabolism_Homo sapiens_hsa009201.84982329
15Nicotine addiction_Homo sapiens_hsa050331.84258859
16Pentose and glucuronate interconversions_Homo sapiens_hsa000401.80210330
17Pyrimidine metabolism_Homo sapiens_hsa002401.79147531
18Insulin secretion_Homo sapiens_hsa049111.76989246
19One carbon pool by folate_Homo sapiens_hsa006701.74432652
20Circadian entrainment_Homo sapiens_hsa047131.66822847
21Glutathione metabolism_Homo sapiens_hsa004801.66447734
22Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.65900857
23GABAergic synapse_Homo sapiens_hsa047271.65733318
24Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.64790627
25Folate biosynthesis_Homo sapiens_hsa007901.60559382
26Carbon metabolism_Homo sapiens_hsa012001.57185386
27Homologous recombination_Homo sapiens_hsa034401.52241331
28Synaptic vesicle cycle_Homo sapiens_hsa047211.51613565
29Nucleotide excision repair_Homo sapiens_hsa034201.46654134
30Galactose metabolism_Homo sapiens_hsa000521.46302003
31Glucagon signaling pathway_Homo sapiens_hsa049221.46115292
32Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.42800422
33PPAR signaling pathway_Homo sapiens_hsa033201.40862143
34Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.39159346
35Amphetamine addiction_Homo sapiens_hsa050311.39136401
362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.35081762
37Dorso-ventral axis formation_Homo sapiens_hsa043201.31021762
38Phenylalanine metabolism_Homo sapiens_hsa003601.26977183
39Glutamatergic synapse_Homo sapiens_hsa047241.26100130
40Cocaine addiction_Homo sapiens_hsa050301.25701680
41N-Glycan biosynthesis_Homo sapiens_hsa005101.25118683
42Huntingtons disease_Homo sapiens_hsa050161.24376367
43Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.23732443
44Spliceosome_Homo sapiens_hsa030401.23294204
45Axon guidance_Homo sapiens_hsa043601.23237359
46Cholinergic synapse_Homo sapiens_hsa047251.23082342
47Dopaminergic synapse_Homo sapiens_hsa047281.21182271
48Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.20983783
49Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.19928381
50Renin secretion_Homo sapiens_hsa049241.19908632
51Carbohydrate digestion and absorption_Homo sapiens_hsa049731.19784034
52Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.18586497
53Gastric acid secretion_Homo sapiens_hsa049711.17812057
54Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.17452071
55Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.16760665
56Long-term potentiation_Homo sapiens_hsa047201.16475894
57Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.12643951
58Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.12188477
59Calcium signaling pathway_Homo sapiens_hsa040201.11837461
60Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.11321207
61Cyanoamino acid metabolism_Homo sapiens_hsa004601.10721159
62Oxidative phosphorylation_Homo sapiens_hsa001901.08235595
63Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.08130468
64B cell receptor signaling pathway_Homo sapiens_hsa046621.05180583
65Fatty acid elongation_Homo sapiens_hsa000621.04069353
66Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.03441573
67Bladder cancer_Homo sapiens_hsa052191.01715888
68p53 signaling pathway_Homo sapiens_hsa041151.01456590
69Phosphatidylinositol signaling system_Homo sapiens_hsa040701.00965421
70Aldosterone synthesis and secretion_Homo sapiens_hsa049251.00749129
71Arginine biosynthesis_Homo sapiens_hsa002201.00492333
72Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.00237550
73Lysine degradation_Homo sapiens_hsa003100.99355171
74Parkinsons disease_Homo sapiens_hsa050120.98455412
75Cell cycle_Homo sapiens_hsa041100.98262758
76Sulfur relay system_Homo sapiens_hsa041220.98258117
77Type II diabetes mellitus_Homo sapiens_hsa049300.97238404
78Primary immunodeficiency_Homo sapiens_hsa053400.97104476
79T cell receptor signaling pathway_Homo sapiens_hsa046600.95978576
80Fanconi anemia pathway_Homo sapiens_hsa034600.95686440
81Non-homologous end-joining_Homo sapiens_hsa034500.95572889
82cGMP-PKG signaling pathway_Homo sapiens_hsa040220.95163593
83cAMP signaling pathway_Homo sapiens_hsa040240.94331242
84Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.94215822
85Proteasome_Homo sapiens_hsa030500.93842742
86Oxytocin signaling pathway_Homo sapiens_hsa049210.93595813
87Fatty acid degradation_Homo sapiens_hsa000710.92148417
88Renal cell carcinoma_Homo sapiens_hsa052110.91598665
89Thyroid cancer_Homo sapiens_hsa052160.91491827
90Non-small cell lung cancer_Homo sapiens_hsa052230.90796632
91Purine metabolism_Homo sapiens_hsa002300.88266143
92Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.87273277
93Propanoate metabolism_Homo sapiens_hsa006400.86317179
94Metabolic pathways_Homo sapiens_hsa011000.85766232
95Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.85649506
96Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.85420842
97Arginine and proline metabolism_Homo sapiens_hsa003300.85240418
98Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.84880967
99Taste transduction_Homo sapiens_hsa047420.84077589
100RNA polymerase_Homo sapiens_hsa030200.82886575
101Circadian rhythm_Homo sapiens_hsa047100.82477487
102Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.82149749
103Alzheimers disease_Homo sapiens_hsa050100.81820881
104Estrogen signaling pathway_Homo sapiens_hsa049150.81795875
105Steroid biosynthesis_Homo sapiens_hsa001000.81606954
106Salivary secretion_Homo sapiens_hsa049700.80726237
107ErbB signaling pathway_Homo sapiens_hsa040120.80678412
108Glioma_Homo sapiens_hsa052140.79715488
109Tyrosine metabolism_Homo sapiens_hsa003500.79417688
110Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.78165758
111Drug metabolism - other enzymes_Homo sapiens_hsa009830.78079556
112MAPK signaling pathway_Homo sapiens_hsa040100.77525906
113Wnt signaling pathway_Homo sapiens_hsa043100.76330357
114Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.76188378
115Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.75438095
116Starch and sucrose metabolism_Homo sapiens_hsa005000.75069325
117Notch signaling pathway_Homo sapiens_hsa043300.73735790
118Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.73610430
119Peroxisome_Homo sapiens_hsa041460.73294729
120Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.71656329
121RNA transport_Homo sapiens_hsa030130.71498635
122Acute myeloid leukemia_Homo sapiens_hsa052210.70479167
123AMPK signaling pathway_Homo sapiens_hsa041520.70145533
124Pancreatic cancer_Homo sapiens_hsa052120.70139228
125Long-term depression_Homo sapiens_hsa047300.68531634
126Maturity onset diabetes of the young_Homo sapiens_hsa049500.67458275
127Chronic myeloid leukemia_Homo sapiens_hsa052200.67082540
128Insulin resistance_Homo sapiens_hsa049310.66797701
129Vascular smooth muscle contraction_Homo sapiens_hsa042700.64355007
130Melanogenesis_Homo sapiens_hsa049160.63634752
131Serotonergic synapse_Homo sapiens_hsa047260.63529878
132Thyroid hormone signaling pathway_Homo sapiens_hsa049190.63417123
133Endocytosis_Homo sapiens_hsa041440.63415582
134Osteoclast differentiation_Homo sapiens_hsa043800.63066354
135Fatty acid metabolism_Homo sapiens_hsa012120.61919899
136Pyruvate metabolism_Homo sapiens_hsa006200.60287293
137Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.59366372
138Glycerolipid metabolism_Homo sapiens_hsa005610.59013388
139Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.58800469
140Inositol phosphate metabolism_Homo sapiens_hsa005620.57958406
141Primary bile acid biosynthesis_Homo sapiens_hsa001200.57891116
142Neurotrophin signaling pathway_Homo sapiens_hsa047220.56220975
143Insulin signaling pathway_Homo sapiens_hsa049100.55850273
144Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.55248283
145Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.54788632
146Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.54641368
147VEGF signaling pathway_Homo sapiens_hsa043700.54596508
148Choline metabolism in cancer_Homo sapiens_hsa052310.54468770
149Phospholipase D signaling pathway_Homo sapiens_hsa040720.54301618
150Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.53955876
151Adipocytokine signaling pathway_Homo sapiens_hsa049200.52938252
152Basal cell carcinoma_Homo sapiens_hsa052170.52497590
153Fatty acid biosynthesis_Homo sapiens_hsa000610.52324689
154Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.52039958
155Selenocompound metabolism_Homo sapiens_hsa004500.50303520
156Bile secretion_Homo sapiens_hsa049760.49972742
157Glycosaminoglycan degradation_Homo sapiens_hsa005310.49404419
158Ras signaling pathway_Homo sapiens_hsa040140.48634918
159Chemical carcinogenesis_Homo sapiens_hsa052040.47755607
160GnRH signaling pathway_Homo sapiens_hsa049120.47493208
161Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.46506922
162Dilated cardiomyopathy_Homo sapiens_hsa054140.46102625
163Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.46045477
164Staphylococcus aureus infection_Homo sapiens_hsa051500.45988623
165Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.45680037
166Central carbon metabolism in cancer_Homo sapiens_hsa052300.45153743
167Gap junction_Homo sapiens_hsa045400.44686682
168Herpes simplex infection_Homo sapiens_hsa051680.44434687
169Complement and coagulation cascades_Homo sapiens_hsa046100.44375737
170Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.43775289
171Sphingolipid metabolism_Homo sapiens_hsa006000.43368171
172Apoptosis_Homo sapiens_hsa042100.40925732
173Systemic lupus erythematosus_Homo sapiens_hsa053220.36951973
174Other glycan degradation_Homo sapiens_hsa005110.33995241
175Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.30907569
176Viral carcinogenesis_Homo sapiens_hsa052030.29233163
177Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.28815781
178mTOR signaling pathway_Homo sapiens_hsa041500.28439945
179Epstein-Barr virus infection_Homo sapiens_hsa051690.27873629

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