LRRC66

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein belonging to the leucine-rich repeat family of proteins, which are involved in diverse biological processes, including cell adhesion, cellular trafficking, and hormone-receptor interactions. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1intestinal absorption (GO:0050892)8.35498851
2regulation of guanylate cyclase activity (GO:0031282)7.68421563
3angiotensin maturation (GO:0002003)7.11004514
4intestinal cholesterol absorption (GO:0030299)6.92989817
5UDP-N-acetylglucosamine metabolic process (GO:0006047)6.33880718
6positive regulation of guanylate cyclase activity (GO:0031284)5.99867866
7regulation of systemic arterial blood pressure by hormone (GO:0001990)5.86652269
8regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)5.86652269
9endocrine process (GO:0050886)5.86652269
10hormone catabolic process (GO:0042447)5.86303166
11actin filament depolymerization (GO:0030042)5.75741802
12drug catabolic process (GO:0042737)5.61734707
13epoxygenase P450 pathway (GO:0019373)5.58616113
14drug transmembrane transport (GO:0006855)5.54537156
15maintenance of gastrointestinal epithelium (GO:0030277)5.50862439
16drug transport (GO:0015893)5.45886623
17intestinal epithelial cell development (GO:0060576)5.38942939
18regulation of cellular extravasation (GO:0002691)5.24714142
19regulation of systemic arterial blood pressure (GO:0003073)5.24650045
20fat-soluble vitamin biosynthetic process (GO:0042362)5.15888841
21flavonoid metabolic process (GO:0009812)5.07644028
22vitamin A metabolic process (GO:0006776)5.02316463
23receptor guanylyl cyclase signaling pathway (GO:0007168)4.81184297
24bundle of His cell to Purkinje myocyte communication (GO:0086069)4.79553936
25digestive system process (GO:0022600)4.77418966
26regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)4.70390399
27cellular glucuronidation (GO:0052695)4.67608216
28regulation of cGMP biosynthetic process (GO:0030826)4.65480492
29glucuronate metabolic process (GO:0019585)4.54384991
30uronic acid metabolic process (GO:0006063)4.54384991
31urea cycle (GO:0000050)4.49720511
32O-glycan processing (GO:0016266)4.48713770
33regulation of bile acid biosynthetic process (GO:0070857)4.39327532
34modified amino acid transport (GO:0072337)4.38849880
35purine ribonucleoside bisphosphate metabolic process (GO:0034035)4.29848979
363-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)4.29848979
37urate metabolic process (GO:0046415)4.28556864
38renal absorption (GO:0070293)4.25459454
39peptide hormone processing (GO:0016486)4.24675166
40urea metabolic process (GO:0019627)4.22768635
41sulfate transmembrane transport (GO:1902358)4.16682162
42epithelial structure maintenance (GO:0010669)4.12827397
43regulation of vitamin metabolic process (GO:0030656)4.05759268
44positive regulation of respiratory burst (GO:0060267)4.05301051
45sulfur compound transport (GO:0072348)4.04109645
46renal system process involved in regulation of blood volume (GO:0001977)4.01895753
47bicarbonate transport (GO:0015701)4.01177321
48peptide catabolic process (GO:0043171)3.98898144
49positive regulation of pseudopodium assembly (GO:0031274)3.91244901
50glucose 6-phosphate metabolic process (GO:0051156)3.89656426
51nitrogen cycle metabolic process (GO:0071941)3.89175448
52lysine metabolic process (GO:0006553)3.87479273
53lysine catabolic process (GO:0006554)3.87479273
54regulation of cGMP metabolic process (GO:0030823)3.85949031
55excretion (GO:0007588)3.84126044
56arginine metabolic process (GO:0006525)3.83911772
57transepithelial transport (GO:0070633)3.83834513
58adhesion of symbiont to host cell (GO:0044650)3.80701728
59virion attachment to host cell (GO:0019062)3.80701728
60regulation of cholesterol homeostasis (GO:2000188)3.79030785
61regulation of pseudopodium assembly (GO:0031272)3.78825376
62exogenous drug catabolic process (GO:0042738)3.78013747
63toxin transport (GO:1901998)3.76952378
64very-low-density lipoprotein particle assembly (GO:0034379)3.68827566
65membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.64888347
66fructose metabolic process (GO:0006000)3.64796862
67antimicrobial humoral response (GO:0019730)3.62300577
68homocysteine metabolic process (GO:0050667)3.60122487
69glycolipid catabolic process (GO:0019377)3.60088321
70digestion (GO:0007586)3.58190906
71thyroid hormone metabolic process (GO:0042403)3.56016245
72NADH metabolic process (GO:0006734)3.55984092
73glycosphingolipid catabolic process (GO:0046479)3.55457942
74antibacterial humoral response (GO:0019731)3.55219291
75polyol transport (GO:0015791)3.53400045
76calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.51016488
77glomerular filtration (GO:0003094)3.46360711
78positive regulation of glycoprotein biosynthetic process (GO:0010560)3.46175426
79purine nucleotide salvage (GO:0032261)3.45667512
80positive regulation of cGMP biosynthetic process (GO:0030828)3.45645395
81bile acid and bile salt transport (GO:0015721)3.43003163
82midgut development (GO:0007494)3.41460837
83organic cation transport (GO:0015695)3.38427427
84hemidesmosome assembly (GO:0031581)3.37404659
85sulfate transport (GO:0008272)3.34850705
86cellular response to hepatocyte growth factor stimulus (GO:0035729)3.30428714
87response to hepatocyte growth factor (GO:0035728)3.30428714
88transcytosis (GO:0045056)3.30298982
89nucleoside diphosphate biosynthetic process (GO:0009133)3.27519343
90negative regulation of cholesterol transport (GO:0032375)3.25261020
91negative regulation of sterol transport (GO:0032372)3.25261020
92positive regulation of digestive system process (GO:0060456)3.25100967
93drinking behavior (GO:0042756)3.24789949
94sulfation (GO:0051923)3.24650912
95phosphate ion transport (GO:0006817)3.24032836
96cGMP biosynthetic process (GO:0006182)3.23608757
97oligosaccharide catabolic process (GO:0009313)3.22752583
98lipoprotein metabolic process (GO:0042157)3.22643448
99hydrogen peroxide catabolic process (GO:0042744)3.22585363
100membrane repolarization during action potential (GO:0086011)3.22471615
101nonribosomal peptide biosynthetic process (GO:0019184)3.17340796
102ceramide catabolic process (GO:0046514)3.16477985
103renal filtration (GO:0097205)3.15771255
104mRNA modification (GO:0016556)3.14046564
105sperm capacitation (GO:0048240)3.12016877
106auditory receptor cell differentiation (GO:0042491)3.11243866
107alkaloid metabolic process (GO:0009820)3.11180876
108antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.10557674
109vitamin transmembrane transport (GO:0035461)3.09969308
110hepatocyte apoptotic process (GO:0097284)3.08467766
111positive regulation of glycoprotein metabolic process (GO:1903020)3.08131392
112regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.07784645
113glutathione derivative biosynthetic process (GO:1901687)3.06694859
114glutathione derivative metabolic process (GO:1901685)3.06694859
115phosphate ion transmembrane transport (GO:0035435)3.06578394
116glycerol metabolic process (GO:0006071)3.06304441
117plasma lipoprotein particle assembly (GO:0034377)3.05810652
118glomerulus development (GO:0032835)3.04951165
119cellular response to nitric oxide (GO:0071732)3.04536949
120cysteine metabolic process (GO:0006534)3.04047169
121regulation of triglyceride catabolic process (GO:0010896)3.03860853
122bile acid metabolic process (GO:0008206)3.02888884
123quaternary ammonium group transport (GO:0015697)3.02882306
124glutathione biosynthetic process (GO:0006750)3.02472234
125oligosaccharide biosynthetic process (GO:0009312)3.02388705
126positive regulation of cGMP metabolic process (GO:0030825)3.01336805
127phospholipid scrambling (GO:0017121)2.99995259
128cellular carbohydrate catabolic process (GO:0044275)2.99698488
129fucose catabolic process (GO:0019317)2.98852575
130L-fucose metabolic process (GO:0042354)2.98852575
131L-fucose catabolic process (GO:0042355)2.98852575
132triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.98326355
133phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.97546668
134lipoprotein transport (GO:0042953)2.96885318
135glutamine family amino acid biosynthetic process (GO:0009084)2.96608827
136fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.96318787
137regulation of digestive system process (GO:0044058)2.96224761
138sterol homeostasis (GO:0055092)2.96104830
139citrulline biosynthetic process (GO:0019240)2.95882713
140fat-soluble vitamin metabolic process (GO:0006775)2.95702215
141response to phenylpropanoid (GO:0080184)2.95332312
142cGMP-mediated signaling (GO:0019934)2.94512389
143adhesion of symbiont to host (GO:0044406)2.93382772
144aminoglycoside antibiotic metabolic process (GO:0030647)2.93194073
145protein-lipid complex assembly (GO:0065005)2.92782333
146drug metabolic process (GO:0017144)2.92296885
147antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.91743226
148cholesterol homeostasis (GO:0042632)2.89292150
149diacylglycerol metabolic process (GO:0046339)2.88200528
150protein O-linked glycosylation (GO:0006493)2.88119348
151sphingolipid catabolic process (GO:0030149)2.87879588
152regulation of protein glycosylation (GO:0060049)2.86760201
153glycosylceramide metabolic process (GO:0006677)2.85716447
154phospholipid efflux (GO:0033700)2.85205032
155glycoside metabolic process (GO:0016137)2.84147648
156positive regulation of lipid catabolic process (GO:0050996)2.83667320
157positive regulation of triglyceride lipase activity (GO:0061365)2.81492339
158positive regulation of lipoprotein lipase activity (GO:0051006)2.81492339
159response to nitric oxide (GO:0071731)2.81391796
160regulation of Golgi to plasma membrane protein transport (GO:0042996)2.80748588
161striated muscle atrophy (GO:0014891)2.80319049

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.94956811
2CDX2_20551321_ChIP-Seq_CACO-2_Human5.74483484
3* SOX2_27498859_Chip-Seq_STOMACH_Mouse3.81691783
4ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.44282177
5HNF4A_19761587_ChIP-ChIP_CACO-2_Human3.36981390
6GATA4_25053715_ChIP-Seq_YYC3_Human3.24580412
7PPARA_22158963_ChIP-Seq_LIVER_Mouse3.13278866
8GATA6_25053715_ChIP-Seq_YYC3_Human3.02030439
9TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.01610222
10CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.81156777
11TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.79161543
12RXR_22158963_ChIP-Seq_LIVER_Mouse2.76063388
13SOX2_20726797_ChIP-Seq_SW620_Human2.60419966
14LXR_22158963_ChIP-Seq_LIVER_Mouse2.50573947
15PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.46677896
16CDX2_19796622_ChIP-Seq_MESCs_Mouse2.40363168
17BP1_19119308_ChIP-ChIP_Hs578T_Human2.26912176
18STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.23182838
19TRIM28_21343339_ChIP-Seq_HEK293_Human2.20505021
20SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.03211547
21FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.02944979
22ESR1_21235772_ChIP-Seq_MCF-7_Human1.96975637
23PPAR_26484153_Chip-Seq_NCI-H1993_Human1.96343427
24IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.95714689
25FOXO3_23340844_ChIP-Seq_DLD1_Human1.86064277
26TCF4_18268006_ChIP-ChIP_LS174T_Human1.83250429
27RUNX1_27514584_Chip-Seq_MCF-7_Human1.83021999
28ESR2_21235772_ChIP-Seq_MCF-7_Human1.78424351
29RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.77872084
30RACK7_27058665_Chip-Seq_MCF-7_Human1.72347370
31SRY_22984422_ChIP-ChIP_TESTIS_Rat1.70992134
32RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.69913613
33* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.64587618
34KLF5_25053715_ChIP-Seq_YYC3_Human1.61087894
35NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.58338310
36AR_21909140_ChIP-Seq_LNCAP_Human1.58313898
37MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.56850415
38KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.56155647
39ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.51399134
40EGR1_23403033_ChIP-Seq_LIVER_Mouse1.51083695
41BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.46188188
42ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.44665323
43TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.42351255
44GATA2_19941826_ChIP-Seq_K562_Human1.41578093
45FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.40629101
46HNF4A_19822575_ChIP-Seq_HepG2_Human1.40579902
47ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.39346439
48ATF3_27146783_Chip-Seq_COLON_Human1.31370607
49CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.30477126
50HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.29973346
51THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.27566857
52ZNF263_19887448_ChIP-Seq_K562_Human1.26521806
53CLOCK_20551151_ChIP-Seq_293T_Human1.25868841
54PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.25556138
55SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.23194912
56IRF8_22096565_ChIP-ChIP_GC-B_Human1.22214580
57AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.21706881
58GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21698166
59PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.19659949
60BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.15700173
61RXR_22108803_ChIP-Seq_LS180_Human1.13594816
62FOXA2_19822575_ChIP-Seq_HepG2_Human1.10553822
63NR3C1_21868756_ChIP-Seq_MCF10A_Human1.08981339
64LXR_22292898_ChIP-Seq_THP-1_Human1.06594874
65VDR_22108803_ChIP-Seq_LS180_Human1.05772636
66GATA1_26923725_Chip-Seq_HPCs_Mouse1.03289649
67NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.02593969
68P63_26484246_Chip-Seq_KERATINOCYTES_Human1.02522100
69HIF1A_21447827_ChIP-Seq_MCF-7_Human1.01469525
70NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.01294481
71EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.98462878
72GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.98414843
73SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.98201265
74SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.98201265
75NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.97937123
76PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.96701521
77SMAD3_21741376_ChIP-Seq_HESCs_Human0.96488461
78ZNF217_24962896_ChIP-Seq_MCF-7_Human0.96259554
79STAT6_21828071_ChIP-Seq_BEAS2B_Human0.93345625
80DROSHA_22980978_ChIP-Seq_HELA_Human0.92505897
81ELF5_23300383_ChIP-Seq_T47D_Human0.92156371
82JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.90823668
83CTCF_27219007_Chip-Seq_Bcells_Human0.89065982
84CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89058259
85CEBPB_22108803_ChIP-Seq_LS180_Human0.88082624
86FOXA1_25552417_ChIP-Seq_VCAP_Human0.85895013
87JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.85732169
88FOXM1_26456572_ChIP-Seq_MCF-7_Human0.85321536
89GATA1_19941826_ChIP-Seq_K562_Human0.84937527
90CREB1_26743006_Chip-Seq_LNCaP_Human0.84548630
91CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.84507623
92SA1_27219007_Chip-Seq_Bcells_Human0.84232086
93TP63_23658742_ChIP-Seq_EP156T_Human0.84149239
94PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.83809617
95VDR_24763502_ChIP-Seq_THP-1_Human0.83033229
96NANOG_20526341_ChIP-Seq_ESCs_Human0.82829944
97EGR1_19032775_ChIP-ChIP_M12_Human0.82400947
98IRF8_21731497_ChIP-ChIP_J774_Mouse0.81962039
99STAT3_1855785_ChIP-Seq_MESCs_Mouse0.81464002
100Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.81177830
101MYB_21317192_ChIP-Seq_ERMYB_Mouse0.81171635
102SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.80862075
103FOXA1_21572438_ChIP-Seq_LNCaP_Human0.80793663
104FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.80577186
105VDR_24787735_ChIP-Seq_THP-1_Human0.80177321
106GATA1_22383799_ChIP-Seq_G1ME_Mouse0.78436316
107CDX2_22108803_ChIP-Seq_LS180_Human0.78027289
108SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.77940076
109PHF8_20622854_ChIP-Seq_HELA_Human0.77632229
110* MYC_27129775_Chip-Seq_CORNEA_Mouse0.77014454
111GATA3_24758297_ChIP-Seq_MCF-7_Human0.76661405
112BCAT_22108803_ChIP-Seq_LS180_Human0.76517543
113GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.76452027
114CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.76283059
115SPI1_23127762_ChIP-Seq_K562_Human0.75920258
116GATA2_21666600_ChIP-Seq_HMVEC_Human0.75500874
117SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.75351060
118SMAD_19615063_ChIP-ChIP_OVARY_Human0.75191371
119CTNNB1_20460455_ChIP-Seq_HCT116_Human0.74762120
120PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.74476139
121DNAJC2_21179169_ChIP-ChIP_NT2_Human0.74215810
122TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.74152131
123P300_27058665_Chip-Seq_ZR-75-30cells_Human0.73819307
124HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.73794511
125FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.73772723
126P68_20966046_ChIP-Seq_HELA_Human0.73689020
127TP63_22573176_ChIP-Seq_HFKS_Human0.73363815
128STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.73151970
129ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.72970942
130RAD21_21589869_ChIP-Seq_MESCs_Mouse0.72694490
131SOX9_24532713_ChIP-Seq_HFSC_Mouse0.72649790
132RARG_19884340_ChIP-ChIP_MEFs_Mouse0.72608648
133SOX2_21211035_ChIP-Seq_LN229_Human0.71664536
134KAP1_22055183_ChIP-Seq_ESCs_Mouse0.71234741
135CJUN_26792858_Chip-Seq_BT549_Human0.70349203
136BCL6_27268052_Chip-Seq_Bcells_Human0.70127438
137TCF4_22108803_ChIP-Seq_LS180_Human0.69810823
138ERG_21242973_ChIP-ChIP_JURKAT_Human0.69616057

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis7.44838286
2MP0001666_abnormal_nutrient_absorption4.34874941
3MP0010234_abnormal_vibrissa_follicle4.17249671
4MP0004043_abnormal_pH_regulation3.87715716
5MP0002139_abnormal_hepatobiliary_system3.54383244
6MP0003866_abnormal_defecation3.47001282
7MP0004264_abnormal_extraembryonic_tissu3.32505675
8MP0000462_abnormal_digestive_system3.12457023
9MP0005085_abnormal_gallbladder_physiolo3.01660769
10MP0001873_stomach_inflammation2.81367282
11MP0004019_abnormal_vitamin_homeostasis2.57310748
12MP0001663_abnormal_digestive_system2.57144892
13MP0003283_abnormal_digestive_organ2.53209208
14MP0008875_abnormal_xenobiotic_pharmacok2.45032184
15MP0003300_gastrointestinal_ulcer2.44703749
16MP0003878_abnormal_ear_physiology2.40512479
17MP0005377_hearing/vestibular/ear_phenot2.40512479
18MP0003252_abnormal_bile_duct2.40121356
19MP0005381_digestive/alimentary_phenotyp2.36729188
20MP0010155_abnormal_intestine_physiology2.35993017
21MP0001765_abnormal_ion_homeostasis2.35536991
22MP0004270_analgesia2.30546879
23MP0009643_abnormal_urine_homeostasis2.27433518
24MP0000490_abnormal_crypts_of2.18383355
25MP0005365_abnormal_bile_salt2.17724551
26MP0005332_abnormal_amino_acid2.11563044
27MP0000538_abnormal_urinary_bladder2.09583552
28MP0001664_abnormal_digestion2.06834860
29MP0002822_catalepsy2.01888787
30MP0010352_gastrointestinal_tract_polyps1.99687109
31MP0009840_abnormal_foam_cell1.85790222
32MP0005636_abnormal_mineral_homeostasis1.84652677
33MP0010329_abnormal_lipoprotein_level1.83907118
34MP0004858_abnormal_nervous_system1.80301776
35MP0004147_increased_porphyrin_level1.70129520
36MP0000477_abnormal_intestine_morphology1.70050805
37MP0003183_abnormal_peptide_metabolism1.57263842
38MP0002136_abnormal_kidney_physiology1.56348553
39MP0001756_abnormal_urination1.51596342
40MP0006054_spinal_hemorrhage1.50853883
41MP0003868_abnormal_feces_composition1.42102885
42MP0001501_abnormal_sleep_pattern1.39122467
43MP0004782_abnormal_surfactant_physiolog1.37719404
44MP0000537_abnormal_urethra_morphology1.34518604
45MP0008004_abnormal_stomach_pH1.31115336
46MP0004885_abnormal_endolymph1.24824302
47MP0002796_impaired_skin_barrier1.23533035
48MP0001188_hyperpigmentation1.22036091
49MP0005310_abnormal_salivary_gland1.20201051
50MP0002089_abnormal_postnatal_growth/wei1.13098825
51MP0003806_abnormal_nucleotide_metabolis1.12531976
52MP0008775_abnormal_heart_ventricle1.10904993
53MP0009379_abnormal_foot_pigmentation1.10592514
54MP0001849_ear_inflammation1.09957438
55MP0005084_abnormal_gallbladder_morpholo1.08250487
56MP0002971_abnormal_brown_adipose1.05342144
57MP0005670_abnormal_white_adipose1.02945978
58MP0003195_calcinosis1.02929344
59MP0003191_abnormal_cellular_cholesterol1.02620122
60MP0010678_abnormal_skin_adnexa1.02042544
61MP0008872_abnormal_physiological_respon0.99943672
62MP0001764_abnormal_homeostasis0.99893751
63MP0001485_abnormal_pinna_reflex0.98092271
64MP0003705_abnormal_hypodermis_morpholog0.97929257
65MP0002138_abnormal_hepatobiliary_system0.94312242
66MP0002876_abnormal_thyroid_physiology0.93805615
67MP0000609_abnormal_liver_physiology0.93679761
68MP0005319_abnormal_enzyme/_coenzyme0.92687193
69MP0004484_altered_response_of0.92399084
70MP0005535_abnormal_body_temperature0.91440594
71MP0005166_decreased_susceptibility_to0.91432825
72MP0004947_skin_inflammation0.91224005
73MP0005167_abnormal_blood-brain_barrier0.88056775
74MP0002896_abnormal_bone_mineralization0.87617836
75MP0000470_abnormal_stomach_morphology0.85833407
76MP0005501_abnormal_skin_physiology0.85405560
77MP0003718_maternal_effect0.84727735
78MP0002118_abnormal_lipid_homeostasis0.83798612
79MP0002098_abnormal_vibrissa_morphology0.82978863
80MP0005584_abnormal_enzyme/coenzyme_acti0.82164830
81MP0002127_abnormal_cardiovascular_syste0.80183674
82MP0000467_abnormal_esophagus_morphology0.78580026
83MP0005451_abnormal_body_composition0.78105157
84MP0001845_abnormal_inflammatory_respons0.74377005
85MP0000249_abnormal_blood_vessel0.73833473
86MP0003638_abnormal_response/metabolism_0.73497478
87MP0000465_gastrointestinal_hemorrhage0.71396933
88MP0005174_abnormal_tail_pigmentation0.69825175
89MP0008961_abnormal_basal_metabolism0.69336031
90MP0004145_abnormal_muscle_electrophysio0.69020668
91MP0005666_abnormal_adipose_tissue0.66826820
92MP0009115_abnormal_fat_cell0.66333603
93MP0004215_abnormal_myocardial_fiber0.65966454
94MP0005330_cardiomyopathy0.64569887
95MP0002166_altered_tumor_susceptibility0.64193122
96MP0005448_abnormal_energy_balance0.62026658
97MP0000749_muscle_degeneration0.61387092
98MP0005058_abnormal_lysosome_morphology0.61262061
99MP0006138_congestive_heart_failure0.61212196
100MP0000013_abnormal_adipose_tissue0.61092541
101MP0001216_abnormal_epidermal_layer0.60678032
102MP0009642_abnormal_blood_homeostasis0.58810136
103MP0002078_abnormal_glucose_homeostasis0.58344919
104MP0005620_abnormal_muscle_contractility0.55460740
105MP0005409_darkened_coat_color0.55386027
106MP0005595_abnormal_vascular_smooth0.55010321
107MP0002254_reproductive_system_inflammat0.53917965
108MP0003879_abnormal_hair_cell0.53855421
109MP0002277_abnormal_respiratory_mucosa0.53656718
110MP0003448_altered_tumor_morphology0.52822821
111MP0000230_abnormal_systemic_arterial0.52343174
112MP0003953_abnormal_hormone_level0.50796228
113MP0009384_cardiac_valve_regurgitation0.50156578
114MP0008469_abnormal_protein_level0.50068179
115MP0003453_abnormal_keratinocyte_physiol0.49993191
116MP0000751_myopathy0.49713796
117MP0000678_abnormal_parathyroid_gland0.49017968
118MP0003646_muscle_fatigue0.48600797
119MP0005334_abnormal_fat_pad0.48323935
120MP0000604_amyloidosis0.48050763
121MP0005165_increased_susceptibility_to0.47827457
122MP0005025_abnormal_response_to0.47420636
123MP0001544_abnormal_cardiovascular_syste0.46989990
124MP0005385_cardiovascular_system_phenoty0.46989990
125MP0003329_amyloid_beta_deposits0.45498705
126MP0000613_abnormal_salivary_gland0.45316958
127MP0000427_abnormal_hair_cycle0.44676946
128MP0003724_increased_susceptibility_to0.44662885
129MP0003315_abnormal_perineum_morphology0.43953925
130MP0000377_abnormal_hair_follicle0.43009377
131MP0002006_tumorigenesis0.42881020
132MP0009764_decreased_sensitivity_to0.41519781
133MP0009785_altered_susceptibility_to0.41297318
134MP0002135_abnormal_kidney_morphology0.40002687
135MP0004742_abnormal_vestibular_system0.39194145

Predicted human phenotypes

RankGene SetZ-score
1Metabolic alkalosis (HP:0200114)7.62101596
2Hyperactive renin-angiotensin system (HP:0000841)7.02656529
3Abnormality of chloride homeostasis (HP:0011422)7.00790954
4Ileus (HP:0002595)6.84919330
5Hypokalemic alkalosis (HP:0001949)5.30163470
6Abnormality of glutamine family amino acid metabolism (HP:0010902)5.09826669
7Increased circulating renin level (HP:0000848)4.80119622
8Hyperaldosteronism (HP:0000859)4.73543205
9Abnormality of renin-angiotensin system (HP:0000847)4.33612213
10Alkalosis (HP:0001948)4.30348834
11Abnormal urine output (HP:0012590)4.28726276
12Malnutrition (HP:0004395)4.24489706
13Hypomagnesemia (HP:0002917)4.22243871
14Abnormality of magnesium homeostasis (HP:0004921)4.09711725
15Abnormality of renal excretion (HP:0011036)4.04051040
16Polyuria (HP:0000103)3.88902288
17Right ventricular cardiomyopathy (HP:0011663)3.84464191
18Systemic lupus erythematosus (HP:0002725)3.84271518
19Dehydration (HP:0001944)3.53934187
20Renal salt wasting (HP:0000127)3.52344760
21Hydroxyprolinuria (HP:0003080)3.49065020
22Abnormality of proline metabolism (HP:0010907)3.49065020
23Tetany (HP:0001281)3.28085614
24Gout (HP:0001997)3.22029747
25Abnormality of urine glucose concentration (HP:0011016)3.20664693
26Glycosuria (HP:0003076)3.20664693
27Proximal tubulopathy (HP:0000114)3.18613165
28Hypokalemia (HP:0002900)3.17206949
29Conjugated hyperbilirubinemia (HP:0002908)3.17031625
30Abnormality of purine metabolism (HP:0004352)3.16677695
31Nausea (HP:0002018)3.06038171
32Widely patent fontanelles and sutures (HP:0004492)3.01308978
33Hyperglycinuria (HP:0003108)2.99913502
34Abdominal distention (HP:0003270)2.99128590
35Congenital sensorineural hearing impairment (HP:0008527)2.94106824
36Chronic diarrhea (HP:0002028)2.90813992
37Hypobetalipoproteinemia (HP:0003563)2.89473007
38Acanthocytosis (HP:0001927)2.86151561
39Onycholysis (HP:0001806)2.84234157
40Increased purine levels (HP:0004368)2.83252766
41Hyperuricemia (HP:0002149)2.83252766
42Autoimmune thrombocytopenia (HP:0001973)2.82464429
43Hypercalciuria (HP:0002150)2.78677562
44Xanthomatosis (HP:0000991)2.69206019
45Abnormality of the vitamin B12 metabolism (HP:0004341)2.66228333
46Hyperphosphatemia (HP:0002905)2.66169356
47Hyperphosphaturia (HP:0003109)2.65069994
48Steatorrhea (HP:0002570)2.63861088
49Abnormal drinking behavior (HP:0030082)2.61457518
50Polydipsia (HP:0001959)2.61457518
51Hyponatremia (HP:0002902)2.59603220
52Flat acetabular roof (HP:0003180)2.59017897
53Hyperparathyroidism (HP:0000843)2.55841373
54Pustule (HP:0200039)2.53595711
55Pigmentary retinal degeneration (HP:0001146)2.52363548
56Microretrognathia (HP:0000308)2.51075304
57Villous atrophy (HP:0011473)2.49888720
58Abnormality of small intestinal villus morphology (HP:0011472)2.49888720
59Abnormality of potassium homeostasis (HP:0011042)2.49518445
60Hypolipoproteinemia (HP:0010981)2.48965762
61Hemorrhage of the eye (HP:0011885)2.46504882
62Abnormality of sodium homeostasis (HP:0010931)2.44700744
63Milia (HP:0001056)2.44606571
64Myopathic facies (HP:0002058)2.43686150
65Gastrointestinal dysmotility (HP:0002579)2.42066588
66Abnormality of vitamin B metabolism (HP:0004340)2.41475153
67Adrenal overactivity (HP:0002717)2.39491888
68Abnormality of aspartate family amino acid metabolism (HP:0010899)2.38571198
69Fat malabsorption (HP:0002630)2.36071053
70Rhabdomyolysis (HP:0003201)2.35491644
71Potter facies (HP:0002009)2.35088679
72Facial shape deformation (HP:0011334)2.35088679
73Posterior subcapsular cataract (HP:0007787)2.33807576
74Abnormal urine phosphate concentration (HP:0012599)2.32898715
75Hypotension (HP:0002615)2.32067543
76Abnormality of fatty-acid metabolism (HP:0004359)2.31647165
77Decreased circulating renin level (HP:0003351)2.27755800
78Thin bony cortex (HP:0002753)2.27740268
79Abnormal tarsal ossification (HP:0008369)2.26926875
80Abnormality of the costochondral junction (HP:0000919)2.26233640
81Abnormality of nucleobase metabolism (HP:0010932)2.25454255
82Focal segmental glomerulosclerosis (HP:0000097)2.24933505
83Megaloblastic anemia (HP:0001889)2.20690444
84Muscle fiber inclusion bodies (HP:0100299)2.20308289
85Hyperammonemia (HP:0001987)2.19694664
86Enlarged epiphyses (HP:0010580)2.19458133
87Ureteral stenosis (HP:0000071)2.18677844
88Exercise-induced myalgia (HP:0003738)2.16580955
89Nephrolithiasis (HP:0000787)2.15289023
90Vacuolated lymphocytes (HP:0001922)2.15110926
91Eczematoid dermatitis (HP:0000976)2.13851922
92Nemaline bodies (HP:0003798)2.13391481
93Intrahepatic cholestasis (HP:0001406)2.12668191
94Abnormality of glycine metabolism (HP:0010895)2.11289390
95Abnormality of serine family amino acid metabolism (HP:0010894)2.11289390
96Mildly elevated creatine phosphokinase (HP:0008180)2.11254146
97Abnormality of dicarboxylic acid metabolism (HP:0010995)2.11232013
98Dicarboxylic aciduria (HP:0003215)2.11232013
99Metabolic acidosis (HP:0001942)2.10510516
100Wide cranial sutures (HP:0010537)2.08785372
101Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.07959919
102Ketoacidosis (HP:0001993)2.07199564
103Palpitations (HP:0001962)2.01766158
104Late onset (HP:0003584)2.01095743
105Cerebral palsy (HP:0100021)2.00909121
106Abnormality of sulfur amino acid metabolism (HP:0004339)2.00435387
107Ureteral obstruction (HP:0006000)2.00297691
108Syncope (HP:0001279)2.00195821
109Autoimmune hemolytic anemia (HP:0001890)1.99991330
110Glomerulonephritis (HP:0000099)1.99867321
111Fragile skin (HP:0001030)1.97490425
112Delayed epiphyseal ossification (HP:0002663)1.97062091
113Increased connective tissue (HP:0009025)1.95697373
114Curly hair (HP:0002212)1.93878074
115Ventricular fibrillation (HP:0001663)1.93174601
116Generalized aminoaciduria (HP:0002909)1.93048216
117Type 1 muscle fiber predominance (HP:0003803)1.92826772
118Goiter (HP:0000853)1.92544068
119Myoglobinuria (HP:0002913)1.92305424
120Pili torti (HP:0003777)1.91694089
121Abnormal biliary tract morphology (HP:0012440)1.91512293
122Multiple lipomas (HP:0001012)1.89390035
123Confusion (HP:0001289)1.89201953
124Cupped ribs (HP:0000887)1.88947311
125Protuberant abdomen (HP:0001538)1.87247337
126Abnormality of the aortic arch (HP:0012303)1.87181641
127Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.85814578
128Abnormality of vitamin metabolism (HP:0100508)1.82741668
129Nephritis (HP:0000123)1.82314738
130Poikilocytosis (HP:0004447)1.82128768
131Renal tubular acidosis (HP:0001947)1.81455810
132Hypophosphatemia (HP:0002148)1.81131757
133Pancreatitis (HP:0001733)1.80203754
134Woolly hair (HP:0002224)1.79811067
135Abnormal glucose tolerance (HP:0001952)1.78860792
136Abnormality of carpal bone ossification (HP:0006257)1.78010587
137Epidermoid cyst (HP:0200040)1.77122031
138Abnormality of the gastric mucosa (HP:0004295)1.75608407
139Abnormality of monocarboxylic acid metabolism (HP:0010996)1.75495409
140Abnormal platelet function (HP:0011869)1.75110306
141Impaired platelet aggregation (HP:0003540)1.75110306
142Rectal prolapse (HP:0002035)1.74647007
143Fragile nails (HP:0001808)1.73142204

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK26.18494311
2ACVR1B6.06396092
3LMTK25.56134976
4MST44.73092090
5MST1R4.44381337
6FRK3.96519278
7OXSR13.68437872
8WNK43.58827067
9WNK33.56881344
10PRKG23.36509456
11NME12.85406445
12GRK62.58902951
13RIPK12.58676510
14EPHA22.41040982
15MAP3K102.36763288
16TLK12.26731475
17MAP2K22.09529613
18MAP3K52.09373338
19PTK61.95250515
20MAP3K21.84978703
21STK391.82020119
22OBSCN1.79957410
23PDK21.56833354
24STK101.55979366
25ERN11.53909167
26MAP4K11.42236111
27EPHA31.38588459
28TESK11.36307043
29TRIB31.34497000
30CDK191.27998824
31CASK1.26493270
32MAP3K121.25521503
33TAOK31.24149393
34RIPK41.22258863
35GRK11.21352180
36TNIK1.19958339
37STK241.18408443
38MATK1.17143916
39AKT31.15990894
40NUAK11.15694582
41MYLK1.13160561
42EPHB11.12436036
43EPHA41.11551837
44EEF2K1.10488456
45KSR21.05543363
46EPHB21.03232692
47PKN21.02637675
48SCYL20.98824179
49MAP3K70.95448181
50FGFR30.95100872
51MAPK110.94595972
52LRRK20.94537057
53NLK0.93953574
54PRKAA20.90921380
55PAK40.90106365
56PDGFRA0.89819628
57MET0.85961849
58PRKCI0.84855573
59PIK3CA0.84574609
60TTK0.83456311
61MAP2K60.82390201
62MAP3K80.81784054
63ERBB20.76450584
64TBK10.73850838
65MAP3K10.72152166
66MAP4K20.71945103
67SIK20.69094931
68PTK20.67064209
69CDC42BPA0.65879205
70MAP2K10.65264069
71SGK30.63974050
72ERBB40.60406013
73PRKAA10.59213278
74RET0.54524893
75BMPR1B0.53287294
76TYK20.53077607
77PIK3CG0.50328472
78FER0.48883037
79MAPKAPK30.48261900
80CDK80.48007212
81PDK10.47345534
82PBK0.47002284
83CAMK2D0.46949719
84TAOK10.45400177
85IRAK30.45331549
86PHKG20.45315699
87PHKG10.45315699
88MELK0.41434196
89RAF10.40853315
90DMPK0.40832165
91MAPK70.40546129
92PDPK10.40170289
93MAP3K30.39336284
94BCR0.38014084
95PRKCZ0.37872774
96JAK10.37241728
97PRPF4B0.35054284
98CAMK2G0.34404373
99MUSK0.32274915
100BLK0.32216892
101PDK40.31854839
102PDK30.31854839
103PRKCA0.29651482
104LIMK10.28461596
105TTN0.27656738
106FGFR40.27561579
107MAP3K110.26841333
108SRC0.26503649
109IRAK10.25136055
110GSK3A0.24790529
111AURKB0.24049222
112CSK0.24012328
113MAP3K130.23876131
114PRKACG0.23504436
115CDK60.23301062
116BMX0.22293798
117PIM20.22039810
118ICK0.21959120
119BCKDK0.21273903
120PAK20.21264456
121CAMK2B0.20418682
122JAK20.20253943
123DYRK1B0.20157709
124DDR20.19409474
125PDGFRB0.18182555
126AKT20.17523361
127TESK20.17273910
128FYN0.17212849
129ABL20.16743079
130CAMK2A0.15861818
131PAK10.15857172
132STK110.15752183
133PAK30.15550144
134PRKG10.15458145
135PRKCD0.15416628
136CSNK1A10.15296498
137NEK10.15294400
138PRKCQ0.14801825
139ROCK10.14572337
140STK38L0.14483811
141SGK2230.14437211
142SGK4940.14437211
143CDK70.14429786
144CDK40.14135023
145HIPK20.13579673
146SIK30.12205609

Predicted pathways (KEGG)

RankGene SetZ-score
1Fat digestion and absorption_Homo sapiens_hsa049753.71777799
2Mineral absorption_Homo sapiens_hsa049783.62067077
3Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.42998347
4Renin-angiotensin system_Homo sapiens_hsa046143.10181152
5Vitamin digestion and absorption_Homo sapiens_hsa049773.05972107
6Sulfur metabolism_Homo sapiens_hsa009202.90980027
7Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.89522737
8Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.69459396
9Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.52498323
10Bile secretion_Homo sapiens_hsa049762.36555820
11Cyanoamino acid metabolism_Homo sapiens_hsa004602.26291536
12Fructose and mannose metabolism_Homo sapiens_hsa000512.23648343
13Carbohydrate digestion and absorption_Homo sapiens_hsa049732.17203942
14Galactose metabolism_Homo sapiens_hsa000522.16950983
15Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.07614558
16Caffeine metabolism_Homo sapiens_hsa002322.01839834
17Starch and sucrose metabolism_Homo sapiens_hsa005001.95291987
18Protein digestion and absorption_Homo sapiens_hsa049741.87224791
19Fatty acid degradation_Homo sapiens_hsa000711.85149748
20Pentose and glucuronate interconversions_Homo sapiens_hsa000401.82569951
21Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.81368935
22Folate biosynthesis_Homo sapiens_hsa007901.81163507
23Histidine metabolism_Homo sapiens_hsa003401.76060719
24Tryptophan metabolism_Homo sapiens_hsa003801.73819470
25Linoleic acid metabolism_Homo sapiens_hsa005911.67617417
26Glutathione metabolism_Homo sapiens_hsa004801.66493392
27Maturity onset diabetes of the young_Homo sapiens_hsa049501.45876862
282-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.45837398
29Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.45203942
30Butanoate metabolism_Homo sapiens_hsa006501.42596621
31Nitrogen metabolism_Homo sapiens_hsa009101.38921174
32Pyruvate metabolism_Homo sapiens_hsa006201.37249864
33Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.36212485
34Carbon metabolism_Homo sapiens_hsa012001.33319637
35Propanoate metabolism_Homo sapiens_hsa006401.32187145
36PPAR signaling pathway_Homo sapiens_hsa033201.30675661
37Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.30498698
38Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.28860968
39Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.28489506
40Glycerolipid metabolism_Homo sapiens_hsa005611.23556311
41Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.20016534
42Pentose phosphate pathway_Homo sapiens_hsa000301.17326283
43Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.16674817
44beta-Alanine metabolism_Homo sapiens_hsa004101.13390563
45Arginine and proline metabolism_Homo sapiens_hsa003301.12892233
46Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.12872868
47Peroxisome_Homo sapiens_hsa041461.06971870
48Asthma_Homo sapiens_hsa053101.03140951
49Other glycan degradation_Homo sapiens_hsa005111.02456050
50Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.97656633
51Arginine biosynthesis_Homo sapiens_hsa002200.93939476
52ABC transporters_Homo sapiens_hsa020100.93313265
53Sphingolipid metabolism_Homo sapiens_hsa006000.92092566
54Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.90049107
55Thyroid hormone synthesis_Homo sapiens_hsa049180.89969502
56Fatty acid metabolism_Homo sapiens_hsa012120.88996135
57Pancreatic secretion_Homo sapiens_hsa049720.82640907
58Gastric acid secretion_Homo sapiens_hsa049710.80755243
59Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.73283662
60Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.66194569
61Biosynthesis of amino acids_Homo sapiens_hsa012300.65542517
62Lysine degradation_Homo sapiens_hsa003100.64850343
63Allograft rejection_Homo sapiens_hsa053300.62302440
64Tight junction_Homo sapiens_hsa045300.61605159
65Renin secretion_Homo sapiens_hsa049240.61256443
66Chemical carcinogenesis_Homo sapiens_hsa052040.60889554
67Thyroid cancer_Homo sapiens_hsa052160.59317772
68Autoimmune thyroid disease_Homo sapiens_hsa053200.58182230
69Leukocyte transendothelial migration_Homo sapiens_hsa046700.54299048
70Drug metabolism - other enzymes_Homo sapiens_hsa009830.52652901
71Graft-versus-host disease_Homo sapiens_hsa053320.51510782
72Hepatitis C_Homo sapiens_hsa051600.50966424
73Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.48992796
74Staphylococcus aureus infection_Homo sapiens_hsa051500.46977379
75Bladder cancer_Homo sapiens_hsa052190.46930296
76Insulin resistance_Homo sapiens_hsa049310.46924892
77Retinol metabolism_Homo sapiens_hsa008300.45205875
78Cocaine addiction_Homo sapiens_hsa050300.44592578
79Metabolic pathways_Homo sapiens_hsa011000.44079107
80Fatty acid biosynthesis_Homo sapiens_hsa000610.43150496
81Salmonella infection_Homo sapiens_hsa051320.42431268
82Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.42277423
83Type I diabetes mellitus_Homo sapiens_hsa049400.41122532
84GnRH signaling pathway_Homo sapiens_hsa049120.39153741
85alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.38212992
86N-Glycan biosynthesis_Homo sapiens_hsa005100.37407663
87Adipocytokine signaling pathway_Homo sapiens_hsa049200.37100432
88Intestinal immune network for IgA production_Homo sapiens_hsa046720.36659597
89Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.34819776
90Glucagon signaling pathway_Homo sapiens_hsa049220.34703047
91Salivary secretion_Homo sapiens_hsa049700.33337631
92Arachidonic acid metabolism_Homo sapiens_hsa005900.30759011
93Selenocompound metabolism_Homo sapiens_hsa004500.29557131
94Tyrosine metabolism_Homo sapiens_hsa003500.26595592
95Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.25788533
96Pertussis_Homo sapiens_hsa051330.25246555
97Vibrio cholerae infection_Homo sapiens_hsa051100.24384753
98Oxidative phosphorylation_Homo sapiens_hsa001900.23439920
99Glycerophospholipid metabolism_Homo sapiens_hsa005640.21327367
100Viral myocarditis_Homo sapiens_hsa054160.19792813
101Insulin secretion_Homo sapiens_hsa049110.18951576
102Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.18045862
103African trypanosomiasis_Homo sapiens_hsa051430.18021810
104Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.17696155
105Antigen processing and presentation_Homo sapiens_hsa046120.17544490
106Steroid hormone biosynthesis_Homo sapiens_hsa001400.16969679
107Sulfur relay system_Homo sapiens_hsa041220.16763392
108Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.16757330
109Inositol phosphate metabolism_Homo sapiens_hsa005620.16683772
110Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.16409987
111Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.15852821
112Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.15493394
113Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.14186654
114Leishmaniasis_Homo sapiens_hsa051400.14118575
115Amphetamine addiction_Homo sapiens_hsa050310.13545545
116Vascular smooth muscle contraction_Homo sapiens_hsa042700.12946153
117Choline metabolism in cancer_Homo sapiens_hsa052310.11352768
118Cysteine and methionine metabolism_Homo sapiens_hsa002700.10527154
119Alzheimers disease_Homo sapiens_hsa050100.10426630
120Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.09771216
121AMPK signaling pathway_Homo sapiens_hsa041520.09069259
122Parkinsons disease_Homo sapiens_hsa050120.09025558
123Influenza A_Homo sapiens_hsa051640.06878291
124Ether lipid metabolism_Homo sapiens_hsa005650.06698977
125Steroid biosynthesis_Homo sapiens_hsa001000.05077225
126Toxoplasmosis_Homo sapiens_hsa051450.04024781
127Phenylalanine metabolism_Homo sapiens_hsa003600.03204868
128NOD-like receptor signaling pathway_Homo sapiens_hsa046210.03152049
129Phosphatidylinositol signaling system_Homo sapiens_hsa040700.02973084
130Adherens junction_Homo sapiens_hsa045200.02903845

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