LRRC69

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1gonadal mesoderm development (GO:0007506)9.93178761
2cell-cell recognition (GO:0009988)9.64065079
3binding of sperm to zona pellucida (GO:0007339)9.54506535
4cilium or flagellum-dependent cell motility (GO:0001539)9.25680250
5axonemal dynein complex assembly (GO:0070286)9.10139919
6reproduction (GO:0000003)9.01906017
7plasma membrane fusion (GO:0045026)8.94205842
8spermatid development (GO:0007286)8.62590103
9epithelial cilium movement (GO:0003351)8.01910946
10regulation of cilium movement (GO:0003352)7.42358875
11sperm capacitation (GO:0048240)7.22244975
12motile cilium assembly (GO:0044458)7.15870442
13single fertilization (GO:0007338)6.79683184
14male meiosis (GO:0007140)6.77117468
15positive regulation of RNA splicing (GO:0033120)6.70836215
16cilium movement (GO:0003341)6.69521541
17membrane depolarization during cardiac muscle cell action potential (GO:0086012)6.51662419
18synaptonemal complex assembly (GO:0007130)6.49872721
19synaptonemal complex organization (GO:0070193)6.45905427
20fertilization (GO:0009566)5.91595167
21membrane repolarization during cardiac muscle cell action potential (GO:0086013)5.91177640
22epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.77839904
23spermatogenesis (GO:0007283)5.77640124
24male gamete generation (GO:0048232)5.75113484
25negative regulation of inclusion body assembly (GO:0090084)5.61831456
26organic cation transport (GO:0015695)5.59617126
27DNA deamination (GO:0045006)5.55985800
28piRNA metabolic process (GO:0034587)5.51814590
29behavioral response to nicotine (GO:0035095)5.39456371
30membrane repolarization during action potential (GO:0086011)5.34433421
31gamete generation (GO:0007276)5.32036081
32spermatid nucleus differentiation (GO:0007289)5.23493361
33microtubule depolymerization (GO:0007019)5.23244277
34ventricular system development (GO:0021591)5.08054172
35germ cell development (GO:0007281)4.99601909
36cellular process involved in reproduction in multicellular organism (GO:0022412)4.96146678
37calcium ion-dependent exocytosis (GO:0017156)4.91484599
38positive regulation of macrophage activation (GO:0043032)4.64456809
39cell recognition (GO:0008037)4.62308507
40chromosome organization involved in meiosis (GO:0070192)4.62143358
41regulation of inclusion body assembly (GO:0090083)4.51719188
42positive regulation of mRNA processing (GO:0050685)4.51522599
43water-soluble vitamin biosynthetic process (GO:0042364)4.43714604
44glycerol ether metabolic process (GO:0006662)4.40810663
45mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.36678572
46mitochondrial respiratory chain complex I assembly (GO:0032981)4.36678572
47NADH dehydrogenase complex assembly (GO:0010257)4.36678572
48male meiosis I (GO:0007141)4.33105752
49regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.33022115
50multicellular organismal reproductive process (GO:0048609)4.26448996
51regulation of mesoderm development (GO:2000380)4.19732125
52regulation of microtubule-based movement (GO:0060632)4.18745093
53lactate metabolic process (GO:0006089)4.15043586
54microtubule severing (GO:0051013)4.09880373
55protein complex biogenesis (GO:0070271)4.05041438
56ether metabolic process (GO:0018904)4.04244741
57complement activation, alternative pathway (GO:0006957)3.93829385
58chromosome condensation (GO:0030261)3.93436691
59protein K11-linked deubiquitination (GO:0035871)3.86622369
60sexual reproduction (GO:0019953)3.85531014
61magnesium ion transport (GO:0015693)3.82872557
62membrane repolarization (GO:0086009)3.81983081
63protein localization to synapse (GO:0035418)3.80490748
64positive regulation of mRNA metabolic process (GO:1903313)3.78478037
65sulfation (GO:0051923)3.76377269
66meiotic nuclear division (GO:0007126)3.71433361
67mitochondrial respiratory chain complex assembly (GO:0033108)3.70739372
68regulation of skeletal muscle contraction (GO:0014819)3.70420752
69cellular response to arsenic-containing substance (GO:0071243)3.69981948
70DNA packaging (GO:0006323)3.62846759
71seminiferous tubule development (GO:0072520)3.59132910
72DNA dealkylation (GO:0035510)3.57004872
73regulation of membrane repolarization (GO:0060306)3.53878452
74pantothenate metabolic process (GO:0015939)3.50754740
75synapsis (GO:0007129)3.48845543
76glomerulus development (GO:0032835)3.47109595
77DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.43278912
78DNA methylation involved in gamete generation (GO:0043046)3.41657701
79parturition (GO:0007567)3.37519693
80genitalia morphogenesis (GO:0035112)3.34691401
81multicellular organismal development (GO:0007275)3.33077868
82positive regulation of potassium ion transmembrane transport (GO:1901381)3.31599435
83meiosis I (GO:0007127)3.31496518
84left/right pattern formation (GO:0060972)3.31355710
85indolalkylamine metabolic process (GO:0006586)3.28304381
86positive regulation of male gonad development (GO:2000020)3.26339430
87cellular response to exogenous dsRNA (GO:0071360)3.24135929
88somite development (GO:0061053)3.23077376
89single strand break repair (GO:0000012)3.14357625
90protein polyglutamylation (GO:0018095)3.09304554
91rRNA catabolic process (GO:0016075)3.05455566
92chaperone-mediated protein complex assembly (GO:0051131)3.02880564
93membrane depolarization during action potential (GO:0086010)3.02635991
94positive regulation of defense response to virus by host (GO:0002230)3.02318802
95indole-containing compound catabolic process (GO:0042436)2.99165329
96indolalkylamine catabolic process (GO:0046218)2.99165329
97tryptophan catabolic process (GO:0006569)2.99165329
98monoubiquitinated protein deubiquitination (GO:0035520)2.97947292
99cAMP catabolic process (GO:0006198)2.97805106
100mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.96488281
101cell proliferation in forebrain (GO:0021846)2.94585716
102DNA damage response, signal transduction resulting in transcription (GO:0042772)2.91543687
103potassium ion import (GO:0010107)2.90522605
104cellular potassium ion homeostasis (GO:0030007)2.88874417
105regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.88581796
106kynurenine metabolic process (GO:0070189)2.88270817
107energy coupled proton transport, down electrochemical gradient (GO:0015985)2.88187651
108ATP synthesis coupled proton transport (GO:0015986)2.88187651
109serotonin metabolic process (GO:0042428)2.86717222
110mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.86349201
111carnitine transport (GO:0015879)2.86103084
112amino-acid betaine transport (GO:0015838)2.86103084
113protein refolding (GO:0042026)2.83929530
114ovulation cycle (GO:0042698)2.82442767
115fucose catabolic process (GO:0019317)2.81464893
116L-fucose metabolic process (GO:0042354)2.81464893
117L-fucose catabolic process (GO:0042355)2.81464893
118primary amino compound metabolic process (GO:1901160)2.81165103
119regulation of heart rate by cardiac conduction (GO:0086091)2.80482791
120negative regulation of telomere maintenance (GO:0032205)2.79072984
121regulation of germinal center formation (GO:0002634)2.78616600
122negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.77546652
123axoneme assembly (GO:0035082)2.77283697
124negative regulation of mast cell activation (GO:0033004)2.75652694
125cellular response to electrical stimulus (GO:0071257)2.75474362
126meiotic cell cycle (GO:0051321)2.75163390
127regulation of glomerulus development (GO:0090192)2.74535487
128protein localization to cilium (GO:0061512)2.74125086
129establishment of protein localization to mitochondrial membrane (GO:0090151)2.73644925
130carnitine transmembrane transport (GO:1902603)2.73171626
131negative regulation of synaptic transmission, GABAergic (GO:0032229)2.70303765
132cell differentiation involved in metanephros development (GO:0072202)2.69144785
133negative regulation of systemic arterial blood pressure (GO:0003085)2.66635859
134diaphragm development (GO:0060539)2.66536273
135microtubule polymerization or depolymerization (GO:0031109)2.66138781
136indole-containing compound metabolic process (GO:0042430)2.65797485
137regulation of male gonad development (GO:2000018)2.65588886
138lymph vessel development (GO:0001945)2.65568190
139detection of light stimulus involved in visual perception (GO:0050908)2.64505005
140detection of light stimulus involved in sensory perception (GO:0050962)2.64505005
141cyclic nucleotide catabolic process (GO:0009214)2.64186172
142platelet dense granule organization (GO:0060155)2.64018932
143cellular response to ATP (GO:0071318)2.63363521
144nuclear pore complex assembly (GO:0051292)2.62976877
145glycolytic process (GO:0006096)2.62541582
146gamma-aminobutyric acid transport (GO:0015812)2.62380256
147cardiovascular system development (GO:0072358)2.61327017
148regulation of potassium ion transmembrane transport (GO:1901379)2.61089880
149regulation of female gonad development (GO:2000194)2.60909838
150nucleoside diphosphate catabolic process (GO:0009134)2.59989527
151regulation of posttranscriptional gene silencing (GO:0060147)2.58961435
152regulation of gene silencing by miRNA (GO:0060964)2.58961435
153regulation of gene silencing by RNA (GO:0060966)2.58961435
154positive regulation of endothelial cell differentiation (GO:0045603)2.58649705
155endoderm formation (GO:0001706)2.58083790
156negative regulation of T cell differentiation in thymus (GO:0033085)2.57959359
157negative regulation of appetite (GO:0032099)2.57221153
158negative regulation of response to food (GO:0032096)2.57221153
159regulation of endothelial cell differentiation (GO:0045601)2.57210624
160positive regulation of fatty acid oxidation (GO:0046321)2.57166684
161negative regulation of skeletal muscle tissue development (GO:0048642)2.57133982
162response to xenobiotic stimulus (GO:0009410)2.56770364
163ADP metabolic process (GO:0046031)2.56031328
164protein-cofactor linkage (GO:0018065)2.54930380
165negative regulation of transcription regulatory region DNA binding (GO:2000678)2.54627565
166adaptation of signaling pathway (GO:0023058)2.54201591
167regulation of DNA endoreduplication (GO:0032875)2.54107101
168negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway (GO:1902176)2.53666038
169nucleus organization (GO:0006997)2.53572264
170regulation of rhodopsin mediated signaling pathway (GO:0022400)2.52995931
171regulation of hippo signaling (GO:0035330)2.52650728
172regulation of synapse maturation (GO:0090128)2.52319749
173preassembly of GPI anchor in ER membrane (GO:0016254)2.50989745
174tryptophan metabolic process (GO:0006568)2.50869283
175peptidyl-glutamic acid modification (GO:0018200)2.50016177
176cellular anion homeostasis (GO:0030002)2.49751966
177regulation of female receptivity (GO:0045924)2.49302869
178multicellular organismal signaling (GO:0035637)2.48736322
179meiotic cell cycle process (GO:1903046)2.47061764
180respiratory tube development (GO:0030323)2.46857731
181transmission of nerve impulse (GO:0019226)2.46830504
182purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.44835147
1833-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.44835147
184synaptic transmission, cholinergic (GO:0007271)2.43768556
185dentate gyrus development (GO:0021542)2.43670990
186positive regulation of synapse maturation (GO:0090129)2.43125644
187detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.43040369
188cellular ketone body metabolic process (GO:0046950)2.42756053
189rhodopsin mediated signaling pathway (GO:0016056)2.42716687
190sperm motility (GO:0030317)12.5428846
191cell wall macromolecule metabolic process (GO:0044036)12.2597787
192cell wall macromolecule catabolic process (GO:0016998)12.2597787
193acrosome assembly (GO:0001675)12.0332118
194fusion of sperm to egg plasma membrane (GO:0007342)11.8315990
195acrosome reaction (GO:0007340)11.0229318
196sperm-egg recognition (GO:0035036)10.7635298
197multicellular organism reproduction (GO:0032504)10.4944173

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse6.79276275
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.27388478
3EZH2_22144423_ChIP-Seq_EOC_Human3.88551689
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.36095990
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.11637924
6PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse3.08684183
7STAT6_21828071_ChIP-Seq_BEAS2B_Human2.82116529
8GBX2_23144817_ChIP-Seq_PC3_Human2.66782804
9* KAP1_22055183_ChIP-Seq_ESCs_Mouse2.51979316
10KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse2.44161225
11HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.42785514
12FLI1_27457419_Chip-Seq_LIVER_Mouse2.34536495
13EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.31306395
14CBX2_27304074_Chip-Seq_ESCs_Mouse2.19342074
15BMI1_23680149_ChIP-Seq_NPCS_Mouse2.16643606
16PCGF2_27294783_Chip-Seq_ESCs_Mouse2.07141088
17CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.00127280
18EWS_26573619_Chip-Seq_HEK293_Human1.95893437
19RNF2_27304074_Chip-Seq_NSC_Mouse1.90880016
20CTBP1_25329375_ChIP-Seq_LNCAP_Human1.90615881
21ZFP57_27257070_Chip-Seq_ESCs_Mouse1.87131865
22EED_16625203_ChIP-ChIP_MESCs_Mouse1.83975489
23TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.82135486
24PCGF2_27294783_Chip-Seq_NPCs_Mouse1.81635019
25RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.81352308
26POU3F2_20337985_ChIP-ChIP_501MEL_Human1.76656578
27P300_19829295_ChIP-Seq_ESCs_Human1.76043960
28JARID2_20064375_ChIP-Seq_MESCs_Mouse1.75187957
29ZNF274_21170338_ChIP-Seq_K562_Hela1.75075307
30IRF1_19129219_ChIP-ChIP_H3396_Human1.73238962
31STAT1_17558387_ChIP-Seq_HELA_Human1.73060856
32IGF1R_20145208_ChIP-Seq_DFB_Human1.72307285
33GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.72135836
34GATA1_26923725_Chip-Seq_HPCs_Mouse1.70149478
35TAF15_26573619_Chip-Seq_HEK293_Human1.69387174
36FUS_26573619_Chip-Seq_HEK293_Human1.68123932
37EZH2_27304074_Chip-Seq_ESCs_Mouse1.67768443
38NOTCH1_21737748_ChIP-Seq_TLL_Human1.67280770
39KDM2B_26808549_Chip-Seq_REH_Human1.63892877
40GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.63783756
41TAL1_26923725_Chip-Seq_HPCs_Mouse1.63658209
42EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.63312162
43CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.62905023
44FLI1_21867929_ChIP-Seq_TH2_Mouse1.59495710
45IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.57358494
46CBP_20019798_ChIP-Seq_JUKART_Human1.57358494
47HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.57170215
48NFE2_27457419_Chip-Seq_LIVER_Mouse1.56972143
49CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.55802423
50* VDR_22108803_ChIP-Seq_LS180_Human1.55660330
51SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.55641260
52SUZ12_27294783_Chip-Seq_NPCs_Mouse1.54099182
53P53_21459846_ChIP-Seq_SAOS-2_Human1.53584211
54MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.52521214
55JARID2_20075857_ChIP-Seq_MESCs_Mouse1.49750101
56* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.48414125
57ER_23166858_ChIP-Seq_MCF-7_Human1.46886787
58FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.46683234
59MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.45707884
60TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44975222
61CRX_20693478_ChIP-Seq_RETINA_Mouse1.44344482
62AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.44331130
63EGR1_23403033_ChIP-Seq_LIVER_Mouse1.42903400
64SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.41620073
65NANOG_18555785_Chip-Seq_ESCs_Mouse1.41516011
66ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.41326666
67GF1_26923725_Chip-Seq_HPCs_Mouse1.40267139
68GATA3_21867929_ChIP-Seq_TH1_Mouse1.39602771
69SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.39416106
70WDR5_24793694_ChIP-Seq_LNCAP_Human1.38865224
71FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.37958724
72NR3C1_21868756_ChIP-Seq_MCF10A_Human1.37726673
73AR_25329375_ChIP-Seq_VCAP_Human1.37133444
74MYC_27129775_Chip-Seq_CORNEA_Mouse1.35583142
75EZH2_27294783_Chip-Seq_NPCs_Mouse1.35542361
76EZH2_27294783_Chip-Seq_ESCs_Mouse1.35494738
77MYC_18940864_ChIP-ChIP_HL60_Human1.35220733
78MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.34950915
79LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.34510373
80CTBP2_25329375_ChIP-Seq_LNCAP_Human1.34057808
81MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.33994084
82RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.32775087
83PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.31658017
84REST_21632747_ChIP-Seq_MESCs_Mouse1.31070845
85OCT4_21477851_ChIP-Seq_ESCs_Mouse1.30649762
86CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.29786344
87EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.29076641
88SMAD4_21799915_ChIP-Seq_A2780_Human1.29044548
89OCT4_18555785_Chip-Seq_ESCs_Mouse1.28400689
90PIAS1_25552417_ChIP-Seq_VCAP_Human1.27770192
91TP53_22573176_ChIP-Seq_HFKS_Human1.27204869
92SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.27078602
93SPI1_26923725_Chip-Seq_HPCs_Mouse1.26950907
94FOXA1_25329375_ChIP-Seq_VCAP_Human1.26018771
95FOXA1_27270436_Chip-Seq_PROSTATE_Human1.26018771
96STAT3_23295773_ChIP-Seq_U87_Human1.25400455
97CMYC_18555785_Chip-Seq_ESCs_Mouse1.25219037
98GATA3_21867929_ChIP-Seq_CD8_Mouse1.24493108
99PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.24018637
100PRDM14_20953172_ChIP-Seq_ESCs_Human1.23455778
101BCAT_22108803_ChIP-Seq_LS180_Human1.23314634
102SUZ12_27294783_Chip-Seq_ESCs_Mouse1.22851135
103EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.21643143
104GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.21462202
105SOX2_22085726_ChIP-Seq_NPCs_Mouse1.21240425
106RNF2_27304074_Chip-Seq_ESCs_Mouse1.20500050
107ELK4_26923725_Chip-Seq_MESODERM_Mouse1.20427106
108RUNX1_26923725_Chip-Seq_HPCs_Mouse1.20290792
109* NANOG_19829295_ChIP-Seq_ESCs_Human1.20199634
110* SOX2_19829295_ChIP-Seq_ESCs_Human1.20199634
111PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.20109109
112SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.20017779
113* P53_22387025_ChIP-Seq_ESCs_Mouse1.19719726
114ESRRB_18555785_Chip-Seq_ESCs_Mouse1.19477648
115* GATA3_21878914_ChIP-Seq_MCF-7_Human1.19463277
116POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.19007105
117TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19007105
118TDRD3_21172665_ChIP-Seq_MCF-7_Human1.18893052
119KLF4_18555785_Chip-Seq_ESCs_Mouse1.18818615
120SMAD3_21741376_ChIP-Seq_EPCs_Human1.16155597
121IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.15241239
122EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.15061977
123EP300_21415370_ChIP-Seq_HL-1_Mouse1.14738841
124SUZ12_18555785_Chip-Seq_ESCs_Mouse1.14613624
125P300_18555785_Chip-Seq_ESCs_Mouse1.14395550
126GABP_17652178_ChIP-ChIP_JURKAT_Human1.12891187
127CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.12047787
128TCF4_22108803_ChIP-Seq_LS180_Human1.09580087
129TOP2B_26459242_ChIP-Seq_MCF-7_Human1.09321951
130RNF2_18974828_ChIP-Seq_MESCs_Mouse1.08026518
131EZH2_18974828_ChIP-Seq_MESCs_Mouse1.08026518
132KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.07967675
133PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.07454099
134GF1B_26923725_Chip-Seq_HPCs_Mouse1.07226760
135E2F1_18555785_Chip-Seq_ESCs_Mouse1.06583093
136AUTS2_25519132_ChIP-Seq_293T-REX_Human1.06575638
137* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.06202638
138RARA_24833708_ChIP-Seq_LIVER_Mouse1.06095857
139NCOR_22424771_ChIP-Seq_293T_Human1.05853004
140SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.05740654
141* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.05427581
142UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.05077467
143STAT3_18555785_Chip-Seq_ESCs_Mouse1.04622510
144SOX2_18555785_Chip-Seq_ESCs_Mouse1.03675581
145BP1_19119308_ChIP-ChIP_Hs578T_Human1.02370893
146RUNX2_22187159_ChIP-Seq_PCA_Human1.02265135
147IRF8_22096565_ChIP-ChIP_GC-B_Human1.02045078
148AR_20517297_ChIP-Seq_VCAP_Human1.01940355
149PU1_27457419_Chip-Seq_LIVER_Mouse1.01891535
150SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01857836
151STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.00276918
152P53_22127205_ChIP-Seq_FIBROBLAST_Human1.00203595
153OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00182929
154FOXA1_21572438_ChIP-Seq_LNCaP_Human1.00043707
155SALL1_21062744_ChIP-ChIP_HESCs_Human0.99832791
156SMAD4_21741376_ChIP-Seq_EPCs_Human0.99803463
157PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.99765536
158NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.99548805
159SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.98487422
160RXRA_24833708_ChIP-Seq_LIVER_Mouse0.97690779
161RUNX1_27457419_Chip-Seq_LIVER_Mouse0.95748698
162BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.95478777
163NMYC_18555785_Chip-Seq_ESCs_Mouse0.95399366
164* TCF4_23295773_ChIP-Seq_U87_Human0.95236414
165RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.95024398
166SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.94799319
167RAD21_21589869_ChIP-Seq_MESCs_Mouse0.94793415
168NFIB_24661679_ChIP-Seq_LUNG_Mouse0.94110905
169CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.92395847
170RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.92251504
171SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.90995019
172ZFX_18555785_Chip-Seq_ESCs_Mouse0.90060191

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.33939490
2MP0001929_abnormal_gametogenesis4.84357628
3MP0003283_abnormal_digestive_organ4.09970607
4MP0002653_abnormal_ependyma_morphology3.96781664
5MP0008877_abnormal_DNA_methylation3.25312481
6MP0002210_abnormal_sex_determination3.17647419
7MP0004885_abnormal_endolymph3.12629516
8MP0002161_abnormal_fertility/fecundity3.01120932
9MP0005646_abnormal_pituitary_gland2.79601356
10MP0005275_abnormal_skin_tensile2.79418878
11MP0002876_abnormal_thyroid_physiology2.71911483
12MP0003941_abnormal_skin_development2.68982420
13MP0008438_abnormal_cutaneous_collagen2.66929616
14MP0001145_abnormal_male_reproductive2.57547369
15MP0009379_abnormal_foot_pigmentation2.51967855
16MP0002138_abnormal_hepatobiliary_system2.45827466
17MP0003115_abnormal_respiratory_system2.43907969
18MP0001485_abnormal_pinna_reflex2.40331980
19MP0000569_abnormal_digit_pigmentation2.38730835
20MP0000653_abnormal_sex_gland2.27804733
21MP0002102_abnormal_ear_morphology2.22167366
22MP0006072_abnormal_retinal_apoptosis2.21046655
23MP0001968_abnormal_touch/_nociception2.19752192
24MP0002282_abnormal_trachea_morphology2.16069873
25MP0002837_dystrophic_cardiac_calcinosis2.02350134
26MP0003195_calcinosis2.00374311
27MP0005410_abnormal_fertilization14.3965269
28MP0005551_abnormal_eye_electrophysiolog1.99134471
29MP0005503_abnormal_tendon_morphology1.91843103
30MP0003879_abnormal_hair_cell1.88350010
31MP0000631_abnormal_neuroendocrine_gland1.86111762
32MP0004142_abnormal_muscle_tone1.83732222
33MP0002272_abnormal_nervous_system1.81338044
34MP0009745_abnormal_behavioral_response1.80291325
35MP0001440_abnormal_grooming_behavior1.75501430
36MP0002736_abnormal_nociception_after1.68429912
37MP0000049_abnormal_middle_ear1.56654503
38MP0002938_white_spotting1.56066783
39MP0004742_abnormal_vestibular_system1.54783907
40MP0005670_abnormal_white_adipose1.54402854
41MP0005174_abnormal_tail_pigmentation1.51044944
42MP0008872_abnormal_physiological_respon1.50895189
43MP0001958_emphysema1.49395168
44MP0005671_abnormal_response_to1.44305015
45MP0001986_abnormal_taste_sensitivity1.41870079
46MP0005623_abnormal_meninges_morphology1.38906041
47MP0004130_abnormal_muscle_cell1.36463751
48MP0002160_abnormal_reproductive_system1.35813060
49MP0001501_abnormal_sleep_pattern1.35766599
50MP0003119_abnormal_digestive_system1.35507446
51MP0005645_abnormal_hypothalamus_physiol1.33881566
52MP0004133_heterotaxia1.28462440
53MP0009046_muscle_twitch1.28149121
54MP0002733_abnormal_thermal_nociception1.23273976
55MP0002064_seizures1.22278404
56MP0003646_muscle_fatigue1.22167999
57MP0004134_abnormal_chest_morphology1.19322194
58MP0003938_abnormal_ear_development1.13999772
59MP0000026_abnormal_inner_ear1.13572869
60MP0005084_abnormal_gallbladder_morpholo1.13292165
61MP0005647_abnormal_sex_gland1.09196245
62MP0001970_abnormal_pain_threshold1.08762155
63MP0002572_abnormal_emotion/affect_behav1.08638422
64MP0001879_abnormal_lymphatic_vessel1.07272219
65MP0001905_abnormal_dopamine_level1.07241126
66MP0003724_increased_susceptibility_to1.05104185
67MP0000230_abnormal_systemic_arterial1.03189039
68MP0001963_abnormal_hearing_physiology1.02706610
69MP0002557_abnormal_social/conspecific_i0.98978480
70MP0003385_abnormal_body_wall0.98936437
71MP0004043_abnormal_pH_regulation0.97075569
72MP0002277_abnormal_respiratory_mucosa0.96338111
73MP0002822_catalepsy0.95956029
74MP0009053_abnormal_anal_canal0.95187787
75MP0009780_abnormal_chondrocyte_physiolo0.95048282
76MP0003635_abnormal_synaptic_transmissio0.94140688
77MP0002063_abnormal_learning/memory/cond0.93612464
78MP0003136_yellow_coat_color0.93213510
79MP0003718_maternal_effect0.92967415
80MP0003937_abnormal_limbs/digits/tail_de0.92864869
81MP0010386_abnormal_urinary_bladder0.92507189
82MP0004215_abnormal_myocardial_fiber0.92430524
83MP0008775_abnormal_heart_ventricle0.91196067
84MP0002751_abnormal_autonomic_nervous0.89598187
85MP0000534_abnormal_ureter_morphology0.89378870
86MP0004147_increased_porphyrin_level0.88617867
87MP0005389_reproductive_system_phenotype0.88569016
88MP0005195_abnormal_posterior_eye0.86857006
89MP0002139_abnormal_hepatobiliary_system0.86486018
90MP0000383_abnormal_hair_follicle0.86197385
91MP0003890_abnormal_embryonic-extraembry0.85492598
92MP0002734_abnormal_mechanical_nocicepti0.85285365
93MP0002067_abnormal_sensory_capabilities0.84643759
94MP0002184_abnormal_innervation0.83830021
95MP0009115_abnormal_fat_cell0.83056951
96MP0002095_abnormal_skin_pigmentation0.81584505
97MP0001765_abnormal_ion_homeostasis0.80661176
98MP0002752_abnormal_somatic_nervous0.80202126
99MP0003137_abnormal_impulse_conducting0.79947878
100MP0002928_abnormal_bile_duct0.78984216
101MP0003942_abnormal_urinary_system0.78630530
102MP0001119_abnormal_female_reproductive0.77985966
103MP0004085_abnormal_heartbeat0.77545347
104MP0005332_abnormal_amino_acid0.77361930
105MP0000427_abnormal_hair_cycle0.76689064
106MP0000372_irregular_coat_pigmentation0.74622327
107MP0003787_abnormal_imprinting0.74617398
108MP0006292_abnormal_olfactory_placode0.73536525
109MP0008995_early_reproductive_senescence0.72627128
110MP0003878_abnormal_ear_physiology0.71806386
111MP0005377_hearing/vestibular/ear_phenot0.71806386
112MP0001944_abnormal_pancreas_morphology0.70946305
113MP0008057_abnormal_DNA_replication0.70720602
114MP0000428_abnormal_craniofacial_morphol0.68928427
115MP0000767_abnormal_smooth_muscle0.66874283
116MP0006138_congestive_heart_failure0.65927791
117MP0002108_abnormal_muscle_morphology0.65277995
118MP0003699_abnormal_female_reproductive0.64961210
119MP0000920_abnormal_myelination0.57422934
120MP0005388_respiratory_system_phenotype0.55753233
121MP0002133_abnormal_respiratory_system0.55753233
122MP0005167_abnormal_blood-brain_barrier0.52761189
123MP0005394_taste/olfaction_phenotype0.52101846
124MP0005499_abnormal_olfactory_system0.52101846
125MP0002638_abnormal_pupillary_reflex0.51211293
126MP0001177_atelectasis0.51197652
127MP0005409_darkened_coat_color0.49130043
128MP0001175_abnormal_lung_morphology0.49123997
129MP0000467_abnormal_esophagus_morphology0.48942623
130MP0004233_abnormal_muscle_weight0.48156453
131MP0000432_abnormal_head_morphology0.47673979
132MP0001984_abnormal_olfaction0.46623566
133MP0005360_urolithiasis0.44971500
134MP0003011_delayed_dark_adaptation0.42530039
135MP0003880_abnormal_central_pattern0.41478469
136MP0001915_intracranial_hemorrhage0.40781851
137MP0002169_no_abnormal_phenotype0.40742307
138MP0003948_abnormal_gas_homeostasis0.40419711
139MP0002873_normal_phenotype0.40310069
140MP0004036_abnormal_muscle_relaxation0.40251484
141MP0005636_abnormal_mineral_homeostasis0.39996892
142MP0000955_abnormal_spinal_cord0.38897118
143MP0002234_abnormal_pharynx_morphology0.38756596
144MP0003632_abnormal_nervous_system0.37962374
145MP0001614_abnormal_blood_vessel0.37909603
146MP0002925_abnormal_cardiovascular_devel0.37720775
147MP0003806_abnormal_nucleotide_metabolis0.37181467
148MP0003091_abnormal_cell_migration0.36987927
149MP0003631_nervous_system_phenotype0.36801303
150MP0001919_abnormal_reproductive_system0.36409251
151MP0003936_abnormal_reproductive_system0.33753555
152MP0005085_abnormal_gallbladder_physiolo0.33223794
153MP0009250_abnormal_appendicular_skeleto0.32082738
154MP0005380_embryogenesis_phenotype0.31756245
155MP0001672_abnormal_embryogenesis/_devel0.31756245
156MP0004019_abnormal_vitamin_homeostasis0.31723877
157MP0002128_abnormal_blood_circulation0.31616916
158MP0005253_abnormal_eye_physiology0.30789218
159MP0000579_abnormal_nail_morphology0.30528597
160MP0002118_abnormal_lipid_homeostasis0.30353555
161MP0004145_abnormal_muscle_electrophysio0.30324092
162MP0003633_abnormal_nervous_system0.29910917
163MP0001784_abnormal_fluid_regulation0.29222376
164MP0002109_abnormal_limb_morphology0.28287633
165MP0002735_abnormal_chemical_nociception0.28044157
166MP0002086_abnormal_extraembryonic_tissu0.27373312
167MP0003300_gastrointestinal_ulcer0.26834470
168MP0003111_abnormal_nucleus_morphology0.26315421
169MP0002060_abnormal_skin_morphology0.26309583
170MP0006276_abnormal_autonomic_nervous0.25732347
171MP0002116_abnormal_craniofacial_bone0.25446570
172MP0000639_abnormal_adrenal_gland0.25259889
173MP0001661_extended_life_span0.24962530
174MP0001486_abnormal_startle_reflex0.24395285
175MP0008875_abnormal_xenobiotic_pharmacok0.24265626

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory epithelium morphology (HP:0012253)8.00163614
2Abnormal respiratory motile cilium morphology (HP:0005938)8.00163614
3Abnormal respiratory motile cilium physiology (HP:0012261)7.71633170
4Rhinitis (HP:0012384)6.14981074
5Abnormal ciliary motility (HP:0012262)6.13501113
6Chronic bronchitis (HP:0004469)5.85326618
7Infertility (HP:0000789)5.50613939
8Impulsivity (HP:0100710)5.47183205
9Nasal polyposis (HP:0100582)5.24298803
10Global brain atrophy (HP:0002283)4.73873904
11Male infertility (HP:0003251)4.34111892
12Abnormality of the nasal mucosa (HP:0000433)4.28900248
13Abnormal spermatogenesis (HP:0008669)4.24791351
14Clumsiness (HP:0002312)4.18417450
15Bronchitis (HP:0012387)4.07414445
16Nephronophthisis (HP:0000090)3.66906551
17Pancreatic cysts (HP:0001737)3.58949400
18Bronchiectasis (HP:0002110)3.48260017
19Recurrent sinusitis (HP:0011108)3.47367244
20Congenital, generalized hypertrichosis (HP:0004540)3.45890749
21Decreased circulating renin level (HP:0003351)3.41119682
22Abolished electroretinogram (ERG) (HP:0000550)3.41002219
23Congenital stationary night blindness (HP:0007642)3.39299276
24Complement deficiency (HP:0004431)3.37191113
25Glomerulonephritis (HP:0000099)3.37010717
26Azoospermia (HP:0000027)3.32972358
27Abnormality of the nasal septum (HP:0000419)3.30077613
28Megalencephaly (HP:0001355)3.22789284
29Abnormal hair whorl (HP:0010721)3.00704140
30Abnormality of the fingertips (HP:0001211)2.98120177
31Recurrent bronchitis (HP:0002837)2.88806330
32Recurrent otitis media (HP:0000403)2.87223159
33Obstructive sleep apnea (HP:0002870)2.85242672
34Abnormality of the renal cortex (HP:0011035)2.81413710
35Abnormality of the phalanges of the hallux (HP:0010057)2.80649084
36Long foot (HP:0001833)2.80468145
37Methylmalonic acidemia (HP:0002912)2.79320501
38Decreased electroretinogram (ERG) amplitude (HP:0000654)2.77962659
39Abnormality of the aortic arch (HP:0012303)2.74462797
40Abnormality of the renal collecting system (HP:0004742)2.69855949
41Abnormality of complement system (HP:0005339)2.65897925
42Abnormality of the renal medulla (HP:0100957)2.63515332
43Metabolic alkalosis (HP:0200114)2.55257634
44Abnormality of the proximal phalanges of the hand (HP:0009834)2.54143010
45Short hallux (HP:0010109)2.52616315
46Pendular nystagmus (HP:0012043)2.52289674
47Aplasia/Hypoplasia of the tibia (HP:0005772)2.51332080
48Tubular atrophy (HP:0000092)2.48133547
49Abnormality of the phalanges of the 2nd finger (HP:0009541)2.44566722
50Aplasia/Hypoplasia of the hallux (HP:0008362)2.43574188
51Methylmalonic aciduria (HP:0012120)2.43190849
52Gonadotropin excess (HP:0000837)2.41813670
53Abnormality of the middle phalanges of the toes (HP:0010183)2.41092098
54Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.39871636
55Abnormality of alanine metabolism (HP:0010916)2.39871636
56Hyperalaninemia (HP:0003348)2.39871636
57Hypoplastic left heart (HP:0004383)2.36296861
58Chronic sinusitis (HP:0011109)2.36040193
59Chronic hepatic failure (HP:0100626)2.33297593
60Progressive cerebellar ataxia (HP:0002073)2.33099773
61Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.31784603
62Bundle branch block (HP:0011710)2.30766607
63Mitochondrial inheritance (HP:0001427)2.30030041
64IgG deficiency (HP:0004315)2.29559748
65Short tibia (HP:0005736)2.29531214
66Type II lissencephaly (HP:0007260)2.27822783
67Asplenia (HP:0001746)2.25261317
68Abnormal drinking behavior (HP:0030082)2.24395594
69Polydipsia (HP:0001959)2.24395594
70Abnormality of incisor morphology (HP:0011063)2.22590484
71Hypoplasia of the pons (HP:0012110)2.22147909
72Concave nail (HP:0001598)2.21922814
73Congenital sensorineural hearing impairment (HP:0008527)2.20576235
74Renal cortical cysts (HP:0000803)2.20189155
75Acute necrotizing encephalopathy (HP:0006965)2.19782504
76Aplasia/Hypoplasia of the spleen (HP:0010451)2.19754114
77Poor eye contact (HP:0000817)2.18209076
78Hypoplasia of the uterus (HP:0000013)2.17989690
79Genetic anticipation (HP:0003743)2.15296124
80Attenuation of retinal blood vessels (HP:0007843)2.14619922
81Abnormal number of erythroid precursors (HP:0012131)2.14186703
82Abnormality of the parietal bone (HP:0002696)2.13703634
83Abnormality of the phalanges of the 5th finger (HP:0004213)2.13694399
84Depressed nasal tip (HP:0000437)2.13378203
85Aplasia/hypoplasia of the uterus (HP:0008684)2.13113546
86Furrowed tongue (HP:0000221)2.12627799
87Nasolacrimal duct obstruction (HP:0000579)2.12436032
88Abnormal rod and cone electroretinograms (HP:0008323)2.12280499
89Abnormality of the pons (HP:0007361)2.11728175
90Sclerocornea (HP:0000647)2.11703612
91Choroideremia (HP:0001139)2.10750246
92Thyroid-stimulating hormone excess (HP:0002925)2.08808762
93Hypokinesia (HP:0002375)2.08284646
94Stomach cancer (HP:0012126)2.07981735
95Aplasia/Hypoplasia of the patella (HP:0006498)2.06355355
96Small hand (HP:0200055)2.06229816
97Hypoplasia of the ulna (HP:0003022)2.04766065
98Increased CSF lactate (HP:0002490)2.01974792
99Increased corneal curvature (HP:0100692)2.01475951
100Keratoconus (HP:0000563)2.01475951
101Stenosis of the external auditory canal (HP:0000402)2.00684744
102Acute hepatic failure (HP:0006554)2.00380081
103Respiratory insufficiency due to defective ciliary clearance (HP:0200073)11.6229450
104Dynein arm defect of respiratory motile cilia (HP:0012255)10.5837939
105Absent/shortened dynein arms (HP:0200106)10.5837939
106Absent rod-and cone-mediated responses on ERG (HP:0007688)1.99459586
107Symphalangism affecting the phalanges of the hand (HP:0009773)1.97329953
108Short femoral neck (HP:0100864)1.97027886
109Renal dysplasia (HP:0000110)1.93015241
110Shawl scrotum (HP:0000049)1.92432639
111Broad-based gait (HP:0002136)1.91592114
112Progressive macrocephaly (HP:0004481)1.91306913
113Morphological abnormality of the middle ear (HP:0008609)1.89917637
114Chorioretinal atrophy (HP:0000533)1.89022022
115Absent thumb (HP:0009777)1.88741410
116Adactyly (HP:0009776)1.88697408
117Cystic liver disease (HP:0006706)1.88523215
118Gaze-evoked nystagmus (HP:0000640)1.87615377
119Abnormality of cells of the erythroid lineage (HP:0012130)1.86858477
120Fibular aplasia (HP:0002990)1.85882535
121Abnormality of renin-angiotensin system (HP:0000847)1.85662164
122Abnormality of the distal phalanx of the thumb (HP:0009617)1.85586927
123Persistence of primary teeth (HP:0006335)1.85235710
124Abnormality of renal resorption (HP:0011038)1.84806148
125Abnormality of midbrain morphology (HP:0002418)1.84696416
126Molar tooth sign on MRI (HP:0002419)1.84696416
127Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.84461556
128Large for gestational age (HP:0001520)1.82851005
129Spontaneous abortion (HP:0005268)1.82616107
130Lipid accumulation in hepatocytes (HP:0006561)1.82540594
131Decreased central vision (HP:0007663)1.82536695
132Abnormal mitochondria in muscle tissue (HP:0008316)1.81716843
133Optic disc pallor (HP:0000543)1.81636209
134Aplasia/Hypoplasia of the fibula (HP:0006492)1.81040272
135Male pseudohermaphroditism (HP:0000037)1.80646338
136Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.80317383
137Short 4th metacarpal (HP:0010044)1.80317383
138Oligodontia (HP:0000677)1.80229596
139Bony spicule pigmentary retinopathy (HP:0007737)1.80190255
140Acute encephalopathy (HP:0006846)1.78123189
141Short middle phalanx of the 5th finger (HP:0004220)1.78091902
142Nephritis (HP:0000123)1.77567652
143Truncal obesity (HP:0001956)1.74712931
144Tubulointerstitial abnormality (HP:0001969)1.73949162
145Abnormality of the lacrimal duct (HP:0011481)1.73916440
146Abnormal social behavior (HP:0012433)1.71320034
147Impaired social interactions (HP:0000735)1.71320034
148Tubulointerstitial nephritis (HP:0001970)1.71180588
149Abnormality of the columella (HP:0009929)1.69958991
150Abnormality of the nasolacrimal system (HP:0000614)1.69828397
151Dyschromatopsia (HP:0007641)1.67233115
152Hypoplastic heart (HP:0001961)1.67117485
153True hermaphroditism (HP:0010459)1.66271021
154Pancreatic fibrosis (HP:0100732)1.64168713
155Cholecystitis (HP:0001082)1.63609744
156Abnormal gallbladder physiology (HP:0012438)1.63609744
157Stage 5 chronic kidney disease (HP:0003774)1.60935742
158Tubulointerstitial fibrosis (HP:0005576)1.59733208
159Long eyelashes (HP:0000527)1.57626105
160Medial flaring of the eyebrow (HP:0010747)1.57176753
161Dislocated radial head (HP:0003083)1.55290917
162Abnormal biliary tract physiology (HP:0012439)1.55169414
163Bile duct proliferation (HP:0001408)1.55169414
164Acanthocytosis (HP:0001927)1.54654807
165Chronic otitis media (HP:0000389)1.51758285
166Tongue fasciculations (HP:0001308)1.51667043
167Sleep apnea (HP:0010535)1.51540848
168Diastasis recti (HP:0001540)1.49587231
169Poor coordination (HP:0002370)1.49485613
170Microglossia (HP:0000171)1.47956660
171Congenital hepatic fibrosis (HP:0002612)1.47797318
172Abnormality of the radial head (HP:0003995)1.43673784
173Hypoplasia of dental enamel (HP:0006297)1.43671122
174Broad toe (HP:0001837)1.43576286
175Wide anterior fontanel (HP:0000260)1.42894420
176Diminished movement (HP:0002374)1.42885236
177Congenital malformation of the right heart (HP:0011723)1.42424364
178Double outlet right ventricle (HP:0001719)1.42424364
179Self-mutilation (HP:0000742)1.42057299
180Postaxial foot polydactyly (HP:0001830)1.41860547
181Progressive visual loss (HP:0000529)1.41492801
182Muscle fibrillation (HP:0010546)1.38015968
183Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.35760821
184Capillary hemangiomas (HP:0005306)1.35456384
185Severe global developmental delay (HP:0011344)1.33474436

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK37.47084049
2PDK47.47084049
3TLK15.77228951
4TESK15.53503778
5PDK24.73088801
6FRK4.64475695
7PRKD33.96713260
8TAOK33.48143580
9ADRBK23.19942765
10GRK13.16054534
11ICK3.03296185
12ACVR1B2.65317510
13BMPR1B2.55743373
14PTK2B2.48013445
15TXK2.40619646
16SIK22.36409350
17ZAK2.34349618
18NEK22.17169676
19NUAK12.01589299
20MAP4K21.89023277
21STK391.87540555
22WNK41.87520198
23STK381.70983228
24RIPK11.69689106
25MAPK131.69535010
26PDGFRA1.67903836
27INSRR1.64304817
28PHKG21.64214990
29PHKG11.64214990
30ERBB31.54569272
31CAMK41.49547998
32CASK1.18973741
33PDGFRB1.18071717
34OXSR11.17978283
35STK161.17423495
36PDK11.10970904
37BCKDK1.10877451
38DYRK1B1.09803520
39ADRBK11.08470963
40BUB11.08429425
41MAP3K41.03615791
42MAP2K21.02860254
43GRK71.00026375
44MUSK0.98491410
45TIE10.98436509
46IKBKB0.97663005
47DAPK20.96787036
48KIT0.94939033
49GRK60.94849686
50DYRK30.93903780
51NTRK30.91490753
52PRKCZ0.91120235
53TNIK0.89130907
54NEK60.88012496
55ERBB40.87509215
56TEC0.87210376
57PIK3CA0.85801132
58TGFBR10.85643839
59PLK40.84860978
60MST40.81026069
61PLK20.80543263
62PAK30.78744118
63DYRK20.78639990
64PRKCE0.73721810
65RPS6KA60.73529435
66GRK50.71929183
67STK38L0.71697273
68TRPM70.70015069
69PINK10.67718906
70PRKACA0.66715884
71VRK10.64986668
72TTK0.64573008
73PNCK0.64340829
74PDPK10.63116146
75CAMKK20.61622202
76SYK0.59907102
77RIPK40.59536010
78PKN10.58208199
79MAPKAPK30.57239517
80OBSCN0.56366543
81ITK0.56015379
82PRKCQ0.55736424
83RPS6KA50.54658783
84NLK0.54577951
85TYRO30.54035003
86LMTK20.53795248
87NME10.52232352
88CAMK10.51370084
89VRK20.51328803
90STK110.51225034
91EEF2K0.49565511
92IKBKE0.49083815
93CHUK0.48998288
94STK30.48523906
95CAMK2G0.46799905
96RPS6KA20.45635539
97CSNK1A10.45525864
98MAP2K10.45285419
99TAF10.44855277
100CAMK2A0.44251314
101SGK20.44031281
102CSNK1G20.43370875
103BRSK20.42657544
104SGK10.41398209
105MAP3K100.41302007
106PIM10.40555486
107MAPK150.39396930
108MAP2K70.39259840
109WNK10.38696675
110MARK10.38591822
111FGFR30.38403197
112PAK20.38110622
113PRKD20.37484184
114MAPKAPK50.36964759
115CHEK10.36752396
116RPS6KC10.36299320
117RPS6KL10.36299320
118DYRK1A0.35773365
119LYN0.35555706
120SGK30.35020627
121ERBB20.34971905
122CDK20.34612286
123FGFR20.34355079
124PRKCI0.33708640
125MAP4K10.33261726
126SGK4940.32467562
127SGK2230.32467562
128GSK3B0.31815119
129LATS10.30396366
130LATS20.29457095
131PRKCG0.29441799
132CDC42BPA0.28689897
133MAP2K60.27713908
134PRKCD0.25535825
135GSK3A0.25414338
136MTOR0.25280830
137AKT10.25005000
138CDK10.24279863
139CHEK20.22850947
140CCNB10.22226392
141MARK20.22137420
142ABL10.21789283
143PAK40.21366116
144PAK10.21230660
145RPS6KA30.20641702
146MAPK80.20632978
147CAMK2D0.20558648
148MKNK20.20375180
149CAMK2B0.19426042
150TTN0.18902714
151ATM0.18379708
152FLT30.17110762
153PRKCB0.16072556
154NTRK10.15765084
155WNK30.15675424
156LIMK10.15454022
157IGF1R0.15394412
158ZAP700.14894964
159PRKACG0.14114606
160PASK0.13264686
161NTRK20.13039226
162RPS6KB10.12079213
163ATR0.11370083
164PRKG10.10964666
165RET0.10064727
166MAPK140.09844023
167INSR0.08089490
168PRKCA0.08028765
169MAPK100.07923416
170MAPK90.07705256

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004606.41652942
2Taurine and hypotaurine metabolism_Homo sapiens_hsa004304.07916784
3Pantothenate and CoA biosynthesis_Homo sapiens_hsa007703.27068230
4Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.06965931
5Fatty acid biosynthesis_Homo sapiens_hsa000613.02328021
6Oxidative phosphorylation_Homo sapiens_hsa001902.74591953
7Vitamin B6 metabolism_Homo sapiens_hsa007502.66885341
8Pyruvate metabolism_Homo sapiens_hsa006202.53372162
9Maturity onset diabetes of the young_Homo sapiens_hsa049502.40497026
10Glucagon signaling pathway_Homo sapiens_hsa049222.37939663
11Pentose phosphate pathway_Homo sapiens_hsa000302.24835418
12Phototransduction_Homo sapiens_hsa047442.21002506
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.17713003
14Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.14593434
15Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.10406427
16Parkinsons disease_Homo sapiens_hsa050122.08546516
17Propanoate metabolism_Homo sapiens_hsa006402.07531960
18Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.02894563
19alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.96924432
20Ribosome_Homo sapiens_hsa030101.94572130
21Protein export_Homo sapiens_hsa030601.90170029
22Intestinal immune network for IgA production_Homo sapiens_hsa046721.89479669
23Linoleic acid metabolism_Homo sapiens_hsa005911.86848420
24Nitrogen metabolism_Homo sapiens_hsa009101.85493407
25Staphylococcus aureus infection_Homo sapiens_hsa051501.83980152
26Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.80261442
27Morphine addiction_Homo sapiens_hsa050321.74379242
28Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.66898123
29Homologous recombination_Homo sapiens_hsa034401.64849454
30Alzheimers disease_Homo sapiens_hsa050101.63206784
31RNA polymerase_Homo sapiens_hsa030201.62723828
32PPAR signaling pathway_Homo sapiens_hsa033201.62511378
33Caffeine metabolism_Homo sapiens_hsa002321.59704972
34Tryptophan metabolism_Homo sapiens_hsa003801.58247784
35Arachidonic acid metabolism_Homo sapiens_hsa005901.53630075
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.53002024
37Sulfur metabolism_Homo sapiens_hsa009201.51577783
38Glycosaminoglycan degradation_Homo sapiens_hsa005311.51549811
39Amphetamine addiction_Homo sapiens_hsa050311.45303679
40Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.42793669
41Retinol metabolism_Homo sapiens_hsa008301.41530355
42Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.40653815
43Carbohydrate digestion and absorption_Homo sapiens_hsa049731.40605616
44Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.39286513
45Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.37203511
46Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.35410567
47Glutathione metabolism_Homo sapiens_hsa004801.31817013
48Primary immunodeficiency_Homo sapiens_hsa053401.30830755
49Selenocompound metabolism_Homo sapiens_hsa004501.27695185
50Glycerolipid metabolism_Homo sapiens_hsa005611.27107309
51Fatty acid degradation_Homo sapiens_hsa000711.25156919
52Long-term potentiation_Homo sapiens_hsa047201.24702292
53Mineral absorption_Homo sapiens_hsa049781.24412639
54Complement and coagulation cascades_Homo sapiens_hsa046101.23834396
55Serotonergic synapse_Homo sapiens_hsa047261.23826788
56Steroid hormone biosynthesis_Homo sapiens_hsa001401.21089541
57Circadian entrainment_Homo sapiens_hsa047131.20855137
58RNA degradation_Homo sapiens_hsa030181.18361965
59Asthma_Homo sapiens_hsa053101.17524665
60Butanoate metabolism_Homo sapiens_hsa006501.17411380
61Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.17015188
62Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.16168225
63Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.14789197
64Ether lipid metabolism_Homo sapiens_hsa005651.13426132
65GABAergic synapse_Homo sapiens_hsa047271.12287273
66Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.11450694
67Glutamatergic synapse_Homo sapiens_hsa047241.10950454
68Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.09832550
69Fatty acid metabolism_Homo sapiens_hsa012121.08653758
70Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.08471924
71Carbon metabolism_Homo sapiens_hsa012001.07793679
72Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.07148511
73Sulfur relay system_Homo sapiens_hsa041221.06812081
74Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.05140077
75TGF-beta signaling pathway_Homo sapiens_hsa043500.98839530
76Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.98265690
77Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.95127705
78Cocaine addiction_Homo sapiens_hsa050300.95119866
79Glycerophospholipid metabolism_Homo sapiens_hsa005640.94985655
80Notch signaling pathway_Homo sapiens_hsa043300.94888642
81Basal transcription factors_Homo sapiens_hsa030220.90905697
82Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.90772276
83Fat digestion and absorption_Homo sapiens_hsa049750.88886535
84Biosynthesis of amino acids_Homo sapiens_hsa012300.88834829
85Insulin secretion_Homo sapiens_hsa049110.88042418
86Cholinergic synapse_Homo sapiens_hsa047250.83458785
87Graft-versus-host disease_Homo sapiens_hsa053320.81197056
88Renin secretion_Homo sapiens_hsa049240.79160599
89Central carbon metabolism in cancer_Homo sapiens_hsa052300.79034477
90Collecting duct acid secretion_Homo sapiens_hsa049660.78921356
91Peroxisome_Homo sapiens_hsa041460.78644715
92Type I diabetes mellitus_Homo sapiens_hsa049400.78574267
93Oocyte meiosis_Homo sapiens_hsa041140.75082767
94Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.74673212
95Regulation of autophagy_Homo sapiens_hsa041400.74419669
96Allograft rejection_Homo sapiens_hsa053300.73085808
97Autoimmune thyroid disease_Homo sapiens_hsa053200.70712133
98Dorso-ventral axis formation_Homo sapiens_hsa043200.69639563
99Chemical carcinogenesis_Homo sapiens_hsa052040.68513262
100Bile secretion_Homo sapiens_hsa049760.67366576
101One carbon pool by folate_Homo sapiens_hsa006700.66522233
102Taste transduction_Homo sapiens_hsa047420.66018430
103Systemic lupus erythematosus_Homo sapiens_hsa053220.64589255
104Thyroid hormone synthesis_Homo sapiens_hsa049180.64129584
105Phenylalanine metabolism_Homo sapiens_hsa003600.63500686
106Spliceosome_Homo sapiens_hsa030400.61647857
107Ovarian steroidogenesis_Homo sapiens_hsa049130.61183856
108Cysteine and methionine metabolism_Homo sapiens_hsa002700.61005761
109Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.60595458
110Oxytocin signaling pathway_Homo sapiens_hsa049210.59293709
111Hedgehog signaling pathway_Homo sapiens_hsa043400.58497393
112Dopaminergic synapse_Homo sapiens_hsa047280.58434531
113Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.57867212
114Estrogen signaling pathway_Homo sapiens_hsa049150.56648306
115Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.56307194
116Lysine degradation_Homo sapiens_hsa003100.55062466
117Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.54410660
118Legionellosis_Homo sapiens_hsa051340.54297144
119Rheumatoid arthritis_Homo sapiens_hsa053230.52774385
120Pentose and glucuronate interconversions_Homo sapiens_hsa000400.51642556
121Thyroid hormone signaling pathway_Homo sapiens_hsa049190.51376624
122Cardiac muscle contraction_Homo sapiens_hsa042600.51349803
123Adherens junction_Homo sapiens_hsa045200.51183478
124Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.51124271
125Renin-angiotensin system_Homo sapiens_hsa046140.50892983
126Calcium signaling pathway_Homo sapiens_hsa040200.50339079
127Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.49479696
128Huntingtons disease_Homo sapiens_hsa050160.48998087
129Protein digestion and absorption_Homo sapiens_hsa049740.47578089
130Olfactory transduction_Homo sapiens_hsa047400.47154905
131cAMP signaling pathway_Homo sapiens_hsa040240.45193410
132cGMP-PKG signaling pathway_Homo sapiens_hsa040220.44517841
133Purine metabolism_Homo sapiens_hsa002300.44497860
134Fanconi anemia pathway_Homo sapiens_hsa034600.43655013
135Fatty acid elongation_Homo sapiens_hsa000620.43330375
136ABC transporters_Homo sapiens_hsa020100.42899832
137Type II diabetes mellitus_Homo sapiens_hsa049300.42332623
138Metabolic pathways_Homo sapiens_hsa011000.41864342
139Wnt signaling pathway_Homo sapiens_hsa043100.40542230
140Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.39588655
141Nicotine addiction_Homo sapiens_hsa050330.38125938
142Adipocytokine signaling pathway_Homo sapiens_hsa049200.37510209
143Vascular smooth muscle contraction_Homo sapiens_hsa042700.37287202
144HIF-1 signaling pathway_Homo sapiens_hsa040660.37041886
145Nucleotide excision repair_Homo sapiens_hsa034200.36327156
146Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.34556278
147beta-Alanine metabolism_Homo sapiens_hsa004100.33630059
148Pancreatic secretion_Homo sapiens_hsa049720.31964268
149Viral carcinogenesis_Homo sapiens_hsa052030.31868047
150Primary bile acid biosynthesis_Homo sapiens_hsa001200.31432901
151Fructose and mannose metabolism_Homo sapiens_hsa000510.30955741
152Salivary secretion_Homo sapiens_hsa049700.30445441
153RNA transport_Homo sapiens_hsa030130.28485130
154Herpes simplex infection_Homo sapiens_hsa051680.28104052
155Endocytosis_Homo sapiens_hsa041440.27583547
156Vitamin digestion and absorption_Homo sapiens_hsa049770.27535647
157Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.25524545
158Gastric acid secretion_Homo sapiens_hsa049710.25061398
159mRNA surveillance pathway_Homo sapiens_hsa030150.24372283
160Aldosterone synthesis and secretion_Homo sapiens_hsa049250.23902284
161Prostate cancer_Homo sapiens_hsa052150.21913359
162Phosphatidylinositol signaling system_Homo sapiens_hsa040700.21837090

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