LRRC7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to nerve growth factor (GO:1990089)8.37065882
2cellular response to nerve growth factor stimulus (GO:1990090)8.37065882
3cerebral cortex radially oriented cell migration (GO:0021799)7.79487385
4establishment of nucleus localization (GO:0040023)6.99801212
5regulation of heat generation (GO:0031650)6.44481690
6regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)5.83798695
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.75378612
8ionotropic glutamate receptor signaling pathway (GO:0035235)5.72772074
9myelination in peripheral nervous system (GO:0022011)5.72475106
10peripheral nervous system axon ensheathment (GO:0032292)5.72475106
11vocalization behavior (GO:0071625)5.57752968
12regulation of NFAT protein import into nucleus (GO:0051532)5.44063170
13neuron cell-cell adhesion (GO:0007158)5.36220293
14regulation of short-term neuronal synaptic plasticity (GO:0048172)5.31567167
15regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.27924776
16positive regulation of phosphoprotein phosphatase activity (GO:0032516)5.21829494
17glutamate receptor signaling pathway (GO:0007215)5.13927061
18synaptic transmission, glutamatergic (GO:0035249)4.93693264
19nucleoside diphosphate catabolic process (GO:0009134)4.92010655
20protein localization to synapse (GO:0035418)4.91735863
21regulation of glutamate receptor signaling pathway (GO:1900449)4.88528103
22intracellular lipid transport (GO:0032365)4.85216997
23locomotory exploration behavior (GO:0035641)4.81207366
24positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.78091701
25regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.66168002
26neuron-neuron synaptic transmission (GO:0007270)4.62419950
27cerebral cortex cell migration (GO:0021795)4.58875818
28presynaptic membrane assembly (GO:0097105)4.52390730
29synaptic vesicle exocytosis (GO:0016079)4.50349060
30substrate-independent telencephalic tangential migration (GO:0021826)4.50301210
31substrate-independent telencephalic tangential interneuron migration (GO:0021843)4.50301210
32Rac protein signal transduction (GO:0016601)4.49668191
33neurotransmitter-gated ion channel clustering (GO:0072578)4.48779615
34regulation of actin nucleation (GO:0051125)4.48765054
35positive regulation of cardiac muscle cell differentiation (GO:2000727)4.47325590
36negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)4.42649471
37regulation of long-term neuronal synaptic plasticity (GO:0048169)4.29391807
38atrial cardiac muscle cell action potential (GO:0086014)4.27961618
39regulation of excitatory postsynaptic membrane potential (GO:0060079)4.24842263
40neuronal action potential propagation (GO:0019227)4.21795949
41positive regulation of potassium ion transmembrane transport (GO:1901381)4.21744537
42nucleus localization (GO:0051647)4.20727952
43glutamate secretion (GO:0014047)4.20028404
44neuron recognition (GO:0008038)4.19585961
45oxidative phosphorylation (GO:0006119)4.17845922
46positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.16487444
47presynaptic membrane organization (GO:0097090)4.11565676
48regulation of neuronal synaptic plasticity (GO:0048168)4.10725708
49synaptic vesicle maturation (GO:0016188)4.06396465
50exploration behavior (GO:0035640)4.05862594
51regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.05497361
52regulation of postsynaptic membrane potential (GO:0060078)4.04937128
53synaptic vesicle docking involved in exocytosis (GO:0016081)4.01319877
54membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.01017995
55postsynaptic membrane organization (GO:0001941)4.00757510
56regulation of synaptic vesicle exocytosis (GO:2000300)3.99725913
57gamma-aminobutyric acid signaling pathway (GO:0007214)3.96510125
58long-term memory (GO:0007616)3.95851454
59dendritic spine morphogenesis (GO:0060997)3.88051262
60G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.87918332
61positive regulation of membrane potential (GO:0045838)3.87875837
62axonal fasciculation (GO:0007413)3.81417908
63limb bud formation (GO:0060174)3.79212269
64regulation of synapse structural plasticity (GO:0051823)3.79204354
65regulation of dendritic spine morphogenesis (GO:0061001)3.78335181
66negative regulation of nucleotide biosynthetic process (GO:0030809)3.78178940
67negative regulation of purine nucleotide biosynthetic process (GO:1900372)3.78178940
68regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.77595510
69startle response (GO:0001964)3.76740269
70response to histamine (GO:0034776)3.75149898
71negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.75111204
72regulation of synaptic transmission, glutamatergic (GO:0051966)3.72995772
73astrocyte development (GO:0014002)3.71664562
74regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.71505739
75regulation of synaptic vesicle transport (GO:1902803)3.70472600
76transmission of nerve impulse (GO:0019226)3.66644699
77negative regulation of synaptic transmission, GABAergic (GO:0032229)3.64959467
78behavioral defense response (GO:0002209)3.64852907
79behavioral fear response (GO:0001662)3.64852907
80negative regulation of calcium ion-dependent exocytosis (GO:0045955)3.64811935
81positive regulation of synapse maturation (GO:0090129)3.59543287
82regulation of synaptic plasticity (GO:0048167)3.57539273
83adaptation of signaling pathway (GO:0023058)3.57451025
84long-term synaptic potentiation (GO:0060291)3.56860145
85neurotransmitter secretion (GO:0007269)3.56747182
86positive regulation of potassium ion transport (GO:0043268)3.55267091
87pyrimidine nucleobase catabolic process (GO:0006208)3.55245402
88gamma-aminobutyric acid transport (GO:0015812)3.51037299
89regulation of protein kinase A signaling (GO:0010738)3.48180269
90positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.46264622
91membrane depolarization (GO:0051899)3.41575264
92positive regulation of neurotransmitter secretion (GO:0001956)3.39581866
93fear response (GO:0042596)3.36979105
94regulation of dendritic spine development (GO:0060998)3.36355071
95positive regulation of cardiac muscle hypertrophy (GO:0010613)3.34407920
96positive regulation of muscle hypertrophy (GO:0014742)3.34407920
97regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.34393787
98regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.32392101
99G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.29536651
100synaptic vesicle endocytosis (GO:0048488)3.29536363
101regulation of potassium ion transmembrane transporter activity (GO:1901016)3.27815501
102learning (GO:0007612)3.26593766
103membrane depolarization during action potential (GO:0086010)3.25495786
104C4-dicarboxylate transport (GO:0015740)3.25037478
105behavioral response to ethanol (GO:0048149)3.24073658
106regulation of glutamate secretion (GO:0014048)3.22884509
107head development (GO:0060322)3.22844407
108auditory behavior (GO:0031223)3.21666120
109sympathetic nervous system development (GO:0048485)3.21581924
110telencephalon cell migration (GO:0022029)3.21382384
111positive regulation of synaptic transmission, GABAergic (GO:0032230)3.19658653
112membrane hyperpolarization (GO:0060081)3.19172507
113positive regulation of dendritic spine development (GO:0060999)3.18344863
114central nervous system projection neuron axonogenesis (GO:0021952)3.18229836
115negative regulation of multicellular organism growth (GO:0040015)3.17293329
116central nervous system neuron axonogenesis (GO:0021955)3.17116651
117regulation of membrane repolarization (GO:0060306)3.16497605
118synapse assembly (GO:0007416)3.15002452
119behavioral response to cocaine (GO:0048148)3.14605709
120regulation of vesicle fusion (GO:0031338)3.14127747
121positive regulation of neurotransmitter transport (GO:0051590)3.13682446
122regulation of synapse maturation (GO:0090128)3.12706566
123cerebellar Purkinje cell differentiation (GO:0021702)3.09221160
124positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)3.08503461
125layer formation in cerebral cortex (GO:0021819)3.08162762
126response to auditory stimulus (GO:0010996)3.07596823
127regulation of neurotransmitter secretion (GO:0046928)3.06492961
128germ cell migration (GO:0008354)3.06271311
129dendritic spine organization (GO:0097061)3.05978832
130positive regulation of dendritic spine morphogenesis (GO:0061003)3.05940949
131microtubule depolymerization (GO:0007019)3.05631665
132dendrite morphogenesis (GO:0048813)3.03020075
133neurotransmitter transport (GO:0006836)3.02888647
134forebrain cell migration (GO:0021885)3.02611687
135cochlea development (GO:0090102)3.02581017
136prepulse inhibition (GO:0060134)3.01579176
137chemosensory behavior (GO:0007635)3.01571652
138neuronal ion channel clustering (GO:0045161)3.00501989
139L-amino acid import (GO:0043092)2.99576486
140mechanosensory behavior (GO:0007638)2.97811411
141proline transport (GO:0015824)2.96912738
142innervation (GO:0060384)2.96688164
143negative regulation of cAMP biosynthetic process (GO:0030818)2.96083816
144nucleobase catabolic process (GO:0046113)2.95812972
145synaptic transmission (GO:0007268)2.95156476
146regulation of transcription from RNA polymerase III promoter (GO:0006359)2.93778030
147regulation of ARF GTPase activity (GO:0032312)2.93458731
148adrenergic receptor signaling pathway (GO:0071875)2.92979592
149striatum development (GO:0021756)2.91937501
150negative regulation of protein tyrosine kinase activity (GO:0061099)2.91126915
151regulation of respiratory system process (GO:0044065)2.90108693
152cerebellar granule cell differentiation (GO:0021707)2.90102417
153regulation of synaptic transmission (GO:0050804)2.89880373
154positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.89550723
155negative regulation of dendrite development (GO:2000171)2.89318184
156positive regulation of synapse assembly (GO:0051965)2.88894851
157adult walking behavior (GO:0007628)2.88228642
158cranial nerve structural organization (GO:0021604)2.87664811
159behavioral response to nicotine (GO:0035095)2.87485610
160anatomical structure arrangement (GO:0048532)2.86915891
161negative regulation of cyclic nucleotide biosynthetic process (GO:0030803)2.84331706
162facial nerve structural organization (GO:0021612)2.84009118
163dendrite development (GO:0016358)2.83718679
164cAMP-mediated signaling (GO:0019933)2.78611714
165osteoblast development (GO:0002076)2.78052302
166temperature homeostasis (GO:0001659)2.76278522
167polyol transport (GO:0015791)2.76167846
168regulation of potassium ion transmembrane transport (GO:1901379)2.74090742
169negative regulation of cAMP metabolic process (GO:0030815)2.71492516
170RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.67468292
171negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.65463976
172protein localization to endosome (GO:0036010)10.0336089

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.07273359
2RBPJ_22232070_ChIP-Seq_NCS_Mouse5.08829172
3GBX2_23144817_ChIP-Seq_PC3_Human4.52751239
4* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.98860265
5* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.97604441
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.87587344
7SALL1_21062744_ChIP-ChIP_HESCs_Human2.66867736
8* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.54804778
9* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.47043527
10* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.47043527
11* EZH2_27304074_Chip-Seq_ESCs_Mouse2.46397395
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.43299801
13* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.42170108
14ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.35462422
15REST_21632747_ChIP-Seq_MESCs_Mouse2.33997625
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.33196663
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.29420704
18* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.26229396
19DROSHA_22980978_ChIP-Seq_HELA_Human2.24676381
20* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.20479594
21TAF15_26573619_Chip-Seq_HEK293_Human2.15571983
22* RARB_27405468_Chip-Seq_BRAIN_Mouse2.08645099
23RNF2_27304074_Chip-Seq_ESCs_Mouse2.06664511
24GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.06625652
25* ZFP57_27257070_Chip-Seq_ESCs_Mouse2.06139566
26EWS_26573619_Chip-Seq_HEK293_Human2.05176469
27* CTBP2_25329375_ChIP-Seq_LNCAP_Human2.01078352
28EZH2_27294783_Chip-Seq_ESCs_Mouse2.00950049
29* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.98169411
30SUZ12_27294783_Chip-Seq_ESCs_Mouse1.98082979
31* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.95952475
32STAT6_21828071_ChIP-Seq_BEAS2B_Human1.91508078
33SMAD4_21799915_ChIP-Seq_A2780_Human1.84749623
34MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.84005474
35AR_21572438_ChIP-Seq_LNCaP_Human1.82441537
36GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.80767433
37CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.78972881
38PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.78433827
39TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.78134859
40P300_19829295_ChIP-Seq_ESCs_Human1.75334719
41REST_18959480_ChIP-ChIP_MESCs_Mouse1.72953210
42PCGF2_27294783_Chip-Seq_NPCs_Mouse1.72785595
43IKZF1_21737484_ChIP-ChIP_HCT116_Human1.67478565
44CBX2_27304074_Chip-Seq_ESCs_Mouse1.61334243
45SMAD3_21741376_ChIP-Seq_EPCs_Human1.58094367
46SMAD_19615063_ChIP-ChIP_OVARY_Human1.54832202
47FUS_26573619_Chip-Seq_HEK293_Human1.53133039
48* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.52566984
49SUZ12_27294783_Chip-Seq_NPCs_Mouse1.52462407
50IGF1R_20145208_ChIP-Seq_DFB_Human1.50915629
51CBP_20019798_ChIP-Seq_JUKART_Human1.49248198
52IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.49248198
53BMI1_23680149_ChIP-Seq_NPCS_Mouse1.46501386
54PIAS1_25552417_ChIP-Seq_VCAP_Human1.44820426
55SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.42984050
56NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.42600792
57PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.41935530
58RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.41079419
59* STAT3_23295773_ChIP-Seq_U87_Human1.38779851
60AR_25329375_ChIP-Seq_VCAP_Human1.38410036
61CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.37177524
62WDR5_24793694_ChIP-Seq_LNCAP_Human1.35047301
63* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34385242
64TP53_16413492_ChIP-PET_HCT116_Human1.33457542
65TOP2B_26459242_ChIP-Seq_MCF-7_Human1.32967085
66TP63_19390658_ChIP-ChIP_HaCaT_Human1.31233935
67ZNF274_21170338_ChIP-Seq_K562_Hela1.30581949
68* SOX2_21211035_ChIP-Seq_LN229_Gbm1.29948193
69SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28955961
70EZH2_27294783_Chip-Seq_NPCs_Mouse1.28861711
71* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28764103
72KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.26537520
73* TCF4_23295773_ChIP-Seq_U87_Human1.26535256
74NFE2_27457419_Chip-Seq_LIVER_Mouse1.26247899
75CDX2_19796622_ChIP-Seq_MESCs_Mouse1.24668302
76TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.23269289
77ARNT_22903824_ChIP-Seq_MCF-7_Human1.22855123
78* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.22735910
79* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.22558675
80MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.21136777
81RNF2_27304074_Chip-Seq_NSC_Mouse1.21004541
82CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.20662282
83ZNF217_24962896_ChIP-Seq_MCF-7_Human1.19336776
84AHR_22903824_ChIP-Seq_MCF-7_Human1.18849130
85* NANOG_18555785_Chip-Seq_ESCs_Mouse1.18805548
86VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.18551178
87EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.18005262
88* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.16626859
89* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.16337379
90NRF2_20460467_ChIP-Seq_MEFs_Mouse1.15393753
91NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.15393753
92KDM2B_26808549_Chip-Seq_REH_Human1.15254928
93* AR_19668381_ChIP-Seq_PC3_Human1.15136637
94RING1B_27294783_Chip-Seq_ESCs_Mouse1.14339925
95RXR_22108803_ChIP-Seq_LS180_Human1.13845170
96NR3C1_21868756_ChIP-Seq_MCF10A_Human1.13805422
97VDR_22108803_ChIP-Seq_LS180_Human1.13788797
98PRDM14_20953172_ChIP-Seq_ESCs_Human1.13354757
99RUNX2_22187159_ChIP-Seq_PCA_Human1.13152197
100RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.12171371
101NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.12095274
102ERG_21242973_ChIP-ChIP_JURKAT_Human1.11850528
103TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11667827
104P53_22127205_ChIP-Seq_FIBROBLAST_Human1.11405678
105TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10498845
106POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.10498845
107* TP53_18474530_ChIP-ChIP_U2OS_Human1.10025938
108YAP1_20516196_ChIP-Seq_MESCs_Mouse1.07529740
109E2F1_18555785_Chip-Seq_ESCs_Mouse1.07459636
110ER_23166858_ChIP-Seq_MCF-7_Human1.07159343
111MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.06845035
112CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05739256
113EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.05390118
114SUZ12_18555785_Chip-Seq_ESCs_Mouse1.04677812
115FLI1_27457419_Chip-Seq_LIVER_Mouse1.04054147
116SOX9_26525672_Chip-Seq_HEART_Mouse1.03043227
117RING1B_27294783_Chip-Seq_NPCs_Mouse1.02984705
118FLI1_21867929_ChIP-Seq_TH2_Mouse1.02836073
119TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.02441325
120PCGF2_27294783_Chip-Seq_ESCs_Mouse1.01756819
121JUN_21703547_ChIP-Seq_K562_Human1.01502048
122WT1_25993318_ChIP-Seq_PODOCYTE_Human1.01493118
123MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.00421779
124BCAT_22108803_ChIP-Seq_LS180_Human1.00389460
125SMAD3_21741376_ChIP-Seq_HESCs_Human0.99952802
126* P53_22387025_ChIP-Seq_ESCs_Mouse0.99694610
127* CMYC_18555785_Chip-Seq_ESCs_Mouse0.98337080

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.36551951
2MP0003880_abnormal_central_pattern5.55026989
3MP0003635_abnormal_synaptic_transmissio4.04704672
4MP0004043_abnormal_pH_regulation3.82588563
5MP0009745_abnormal_behavioral_response3.53577041
6MP0004270_analgesia3.45065940
7MP0002063_abnormal_learning/memory/cond3.39738089
8MP0002822_catalepsy3.16530086
9MP0001968_abnormal_touch/_nociception3.12089172
10MP0002064_seizures3.10934901
11MP0002572_abnormal_emotion/affect_behav2.99291064
12MP0009046_muscle_twitch2.91147713
13MP0001486_abnormal_startle_reflex2.75032284
14MP0002272_abnormal_nervous_system2.64947019
15MP0002735_abnormal_chemical_nociception2.60610034
16MP0002736_abnormal_nociception_after2.57642015
17MP0001501_abnormal_sleep_pattern2.53012302
18MP0005423_abnormal_somatic_nervous2.48910461
19MP0002249_abnormal_larynx_morphology2.47624183
20MP0002734_abnormal_mechanical_nocicepti2.30876665
21MP0001188_hyperpigmentation2.25674903
22MP0001440_abnormal_grooming_behavior2.23170303
23MP0002067_abnormal_sensory_capabilities2.04470386
24MP0000778_abnormal_nervous_system1.98061580
25MP0000049_abnormal_middle_ear1.95413993
26MP0002751_abnormal_autonomic_nervous1.92727041
27MP0005187_abnormal_penis_morphology1.85051412
28MP0001970_abnormal_pain_threshold1.82501368
29MP0001529_abnormal_vocalization1.81068839
30MP0003787_abnormal_imprinting1.81053483
31MP0005646_abnormal_pituitary_gland1.79948263
32MP0002733_abnormal_thermal_nociception1.79758863
33MP0002557_abnormal_social/conspecific_i1.78874737
34MP0002233_abnormal_nose_morphology1.78058630
35MP0002184_abnormal_innervation1.77957622
36MP0005409_darkened_coat_color1.73710872
37MP0004924_abnormal_behavior1.72917272
38MP0005386_behavior/neurological_phenoty1.72917272
39MP0006276_abnormal_autonomic_nervous1.70503155
40MP0003879_abnormal_hair_cell1.63505283
41MP0000613_abnormal_salivary_gland1.61631964
42MP0001984_abnormal_olfaction1.58927837
43MP0000427_abnormal_hair_cycle1.57049054
44MP0008569_lethality_at_weaning1.55540604
45MP0004811_abnormal_neuron_physiology1.53098693
46MP0005645_abnormal_hypothalamus_physiol1.46303867
47MP0000955_abnormal_spinal_cord1.44261271
48MP0009780_abnormal_chondrocyte_physiolo1.43638007
49MP0008260_abnormal_autophagy1.39551631
50MP0002882_abnormal_neuron_morphology1.36819982
51MP0002066_abnormal_motor_capabilities/c1.35106508
52MP0001986_abnormal_taste_sensitivity1.29751038
53MP0000647_abnormal_sebaceous_gland1.29681512
54MP0004142_abnormal_muscle_tone1.28308186
55MP0001905_abnormal_dopamine_level1.26810896
56MP0003633_abnormal_nervous_system1.24278764
57MP0004858_abnormal_nervous_system1.21872471
58MP0003935_abnormal_craniofacial_develop1.20724541
59MP0001502_abnormal_circadian_rhythm1.18100037
60MP0003329_amyloid_beta_deposits1.17324412
61MP0001299_abnormal_eye_distance/1.16576980
62MP0004742_abnormal_vestibular_system1.16403973
63MP0006292_abnormal_olfactory_placode1.15420326
64MP0002909_abnormal_adrenal_gland1.14581292
65MP0003119_abnormal_digestive_system1.14363125
66MP0004885_abnormal_endolymph1.12466120
67MP0000569_abnormal_digit_pigmentation1.09732155
68MP0002152_abnormal_brain_morphology1.08160637
69MP0003755_abnormal_palate_morphology1.07506393
70MP0003631_nervous_system_phenotype1.05180173
71MP0005171_absent_coat_pigmentation1.02166361
72MP0002653_abnormal_ependyma_morphology1.01548050
73MP0005551_abnormal_eye_electrophysiolog1.01360140
74MP0010386_abnormal_urinary_bladder0.98264073
75MP0001963_abnormal_hearing_physiology0.97312389
76MP0002102_abnormal_ear_morphology0.96541178
77MP0001293_anophthalmia0.94861242
78MP0004145_abnormal_muscle_electrophysio0.94833340
79MP0002697_abnormal_eye_size0.92938389
80MP0004085_abnormal_heartbeat0.92716716
81MP0000631_abnormal_neuroendocrine_gland0.91010404
82MP0002229_neurodegeneration0.90722098
83MP0001485_abnormal_pinna_reflex0.90240955
84MP0002069_abnormal_eating/drinking_beha0.88675733
85MP0008874_decreased_physiological_sensi0.88539714
86MP0001177_atelectasis0.88512601
87MP0008872_abnormal_physiological_respon0.87644746
88MP0003122_maternal_imprinting0.86542739
89MP0009250_abnormal_appendicular_skeleto0.84585538
90MP0002109_abnormal_limb_morphology0.83368344
91MP0003136_yellow_coat_color0.83206637
92MP0002752_abnormal_somatic_nervous0.83127296
93MP0002095_abnormal_skin_pigmentation0.82447013
94MP0002638_abnormal_pupillary_reflex0.80312631
95MP0002876_abnormal_thyroid_physiology0.79551021
96MP0002116_abnormal_craniofacial_bone0.79001642
97MP0002896_abnormal_bone_mineralization0.77581509
98MP0002081_perinatal_lethality0.76034034
99MP0000920_abnormal_myelination0.75848033
100MP0000534_abnormal_ureter_morphology0.73568015
101MP0000026_abnormal_inner_ear0.73473665
102MP0000751_myopathy0.72463418
103MP0000762_abnormal_tongue_morphology0.72410369
104MP0005499_abnormal_olfactory_system0.72032669
105MP0005394_taste/olfaction_phenotype0.72032669
106MP0004510_myositis0.71097195
107MP0001286_abnormal_eye_development0.70313488
108MP0004215_abnormal_myocardial_fiber0.70019659
109MP0004484_altered_response_of0.68769028
110MP0008875_abnormal_xenobiotic_pharmacok0.68471083
111MP0003690_abnormal_glial_cell0.68001489
112MP0001664_abnormal_digestion0.67888767
113MP0002177_abnormal_outer_ear0.67830332
114MP0003632_abnormal_nervous_system0.67127760
115MP0005253_abnormal_eye_physiology0.66701333
116MP0000015_abnormal_ear_pigmentation0.66644926
117MP0003634_abnormal_glial_cell0.66077346
118MP0005535_abnormal_body_temperature0.64000342
119MP0003137_abnormal_impulse_conducting0.61808184
120MP0002837_dystrophic_cardiac_calcinosis0.58873763
121MP0003861_abnormal_nervous_system0.58006853
122MP0008877_abnormal_DNA_methylation0.57870896
123MP0003938_abnormal_ear_development0.55467220
124MP0010770_preweaning_lethality0.53970600
125MP0002082_postnatal_lethality0.53970600
126MP0003075_altered_response_to0.53915643
127MP0010769_abnormal_survival0.52826079
128MP0001943_abnormal_respiration0.51305192
129MP0010768_mortality/aging0.49962474
130MP0003045_fibrosis0.48890549
131MP0002234_abnormal_pharynx_morphology0.46501862

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.68131436
2Long nose (HP:0003189)6.09493726
3Focal seizures (HP:0007359)6.02387024
4Myokymia (HP:0002411)5.99127832
5Conical tooth (HP:0000698)5.90833303
6Epileptic encephalopathy (HP:0200134)5.32440956
7Febrile seizures (HP:0002373)5.16969901
8Reduced antithrombin III activity (HP:0001976)4.81947561
9Hyperventilation (HP:0002883)4.77678934
10Atonic seizures (HP:0010819)4.49388077
11Broad-based gait (HP:0002136)4.44140027
12Neoplasm of the oral cavity (HP:0100649)4.42090152
13Absence seizures (HP:0002121)4.18743220
14Oligodontia (HP:0000677)4.15749591
15Progressive cerebellar ataxia (HP:0002073)4.12089690
16Visual hallucinations (HP:0002367)4.02310861
17Dialeptic seizures (HP:0011146)4.02221748
18Generalized tonic-clonic seizures (HP:0002069)3.93856824
19Gaze-evoked nystagmus (HP:0000640)3.68139592
20Abnormality of the labia minora (HP:0012880)3.52474976
21Bulbous nose (HP:0000414)3.46954681
22Poor eye contact (HP:0000817)3.43360977
23Drooling (HP:0002307)3.35894639
24Excessive salivation (HP:0003781)3.35894639
25Lissencephaly (HP:0001339)3.34969694
26Preaxial foot polydactyly (HP:0001841)3.33246526
27Amblyopia (HP:0000646)3.24687789
28Pachygyria (HP:0001302)3.22403526
29Abnormality of the intrinsic pathway (HP:0010989)3.20516405
30Action tremor (HP:0002345)3.15447067
31Dysmetria (HP:0001310)3.07920073
32Dysdiadochokinesis (HP:0002075)3.07038558
33Absent eyebrow (HP:0002223)3.06588229
34Protruding tongue (HP:0010808)3.05023741
35Absent speech (HP:0001344)3.03026642
36Impaired vibration sensation in the lower limbs (HP:0002166)2.97282968
37Type I transferrin isoform profile (HP:0003642)2.95992504
38Truncal ataxia (HP:0002078)2.95951620
39Hepatoblastoma (HP:0002884)2.95278679
40Abnormal social behavior (HP:0012433)2.92718172
41Impaired social interactions (HP:0000735)2.92718172
42Amyotrophic lateral sclerosis (HP:0007354)2.92127596
43Morphological abnormality of the middle ear (HP:0008609)2.83927206
44Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.83839421
45Heterotopia (HP:0002282)2.76469053
46Epileptiform EEG discharges (HP:0011182)2.75351908
47Supranuclear gaze palsy (HP:0000605)2.69051426
48Scanning speech (HP:0002168)2.68961153
49Abnormality of lateral ventricle (HP:0030047)2.66055053
50Blue irides (HP:0000635)2.65485421
51Abnormality of the pubic bones (HP:0003172)2.65212476
52Urinary bladder sphincter dysfunction (HP:0002839)2.61334217
53Hemiparesis (HP:0001269)2.60534162
54Anxiety (HP:0000739)2.57708307
55Stereotypic behavior (HP:0000733)2.56572344
56Short 4th metacarpal (HP:0010044)2.56141301
57Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.56141301
58Genetic anticipation (HP:0003743)2.51253567
59Spastic tetraparesis (HP:0001285)2.47404130
60Muscular hypotonia of the trunk (HP:0008936)2.45612104
61Fair hair (HP:0002286)2.42865614
62EEG with generalized epileptiform discharges (HP:0011198)2.42276576
63Absent/shortened dynein arms (HP:0200106)2.41720923
64Dynein arm defect of respiratory motile cilia (HP:0012255)2.41720923
65Abnormality of the lower motor neuron (HP:0002366)2.41525508
66Inability to walk (HP:0002540)2.41118995
67Postural instability (HP:0002172)2.41026296
68Impaired smooth pursuit (HP:0007772)2.40353519
69Abnormality of salivation (HP:0100755)2.38459171
70Bilateral microphthalmos (HP:0007633)2.37311648
71Depression (HP:0000716)2.36396378
72Abnormal eating behavior (HP:0100738)2.33613903
73Generalized hypopigmentation of hair (HP:0011358)2.31178671
74Progressive inability to walk (HP:0002505)2.29129813
75Fetal akinesia sequence (HP:0001989)2.27772329
76Hypoplastic ischia (HP:0003175)2.27537972
77Abnormality of binocular vision (HP:0011514)2.25653091
78Diplopia (HP:0000651)2.25653091
79Thickened helices (HP:0000391)2.22268232
80Ankle clonus (HP:0011448)2.21558124
81Widely spaced teeth (HP:0000687)2.19709274
82Hypoplasia of the brainstem (HP:0002365)2.19510781
83Aplasia/Hypoplasia of the brainstem (HP:0007362)2.19510781
84Hypsarrhythmia (HP:0002521)2.18788320
85Fine hair (HP:0002213)2.16442293
86Smooth philtrum (HP:0000319)2.14466978
87Abnormality of the parathyroid morphology (HP:0011766)2.14462411
88Acute lymphatic leukemia (HP:0006721)2.14173154
89Cerebral inclusion bodies (HP:0100314)2.13106029
90Spastic gait (HP:0002064)2.12677380
91Gastroesophageal reflux (HP:0002020)2.12468909
92Mutism (HP:0002300)2.10964172
93Exotropia (HP:0000577)2.10376106
94Abnormality of the ischium (HP:0003174)2.09291978
95Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.07914762
96Abnormal protein N-linked glycosylation (HP:0012347)2.07914762
97Abnormal protein glycosylation (HP:0012346)2.07914762
98Abnormal glycosylation (HP:0012345)2.07914762
99Impaired vibratory sensation (HP:0002495)2.07855629
100Neurofibrillary tangles (HP:0002185)2.07269423
101Generalized myoclonic seizures (HP:0002123)2.07169826
102Spastic tetraplegia (HP:0002510)2.06690712
103Abnormality of ocular smooth pursuit (HP:0000617)2.06056378
104Tented upper lip vermilion (HP:0010804)2.04928578
105Status epilepticus (HP:0002133)2.04080045
106Bradykinesia (HP:0002067)2.03515890
107Abnormality of the corticospinal tract (HP:0002492)2.03328533
108Urinary urgency (HP:0000012)2.03318800
109Torticollis (HP:0000473)2.03313799
110Limb ataxia (HP:0002070)2.01348946
111Cutaneous finger syndactyly (HP:0010554)2.00765354
112Spastic paraplegia (HP:0001258)2.00375655
113Gait imbalance (HP:0002141)1.99436527
114Lower limb amyotrophy (HP:0007210)1.98669398
115Inappropriate behavior (HP:0000719)1.97846882
116Small hand (HP:0200055)1.96191201
117Insidious onset (HP:0003587)1.95172032
118Termporal pattern (HP:0011008)1.95172032
119Pancreatic cysts (HP:0001737)1.94015826
120Hip contracture (HP:0003273)1.93558224
121Syncope (HP:0001279)1.93434489
122Abnormal EKG (HP:0003115)1.93180368
123Paraplegia (HP:0010550)1.92909340
124Bifid tongue (HP:0010297)1.92104487
125Diastasis recti (HP:0001540)1.92005604
126Clumsiness (HP:0002312)1.91397611
127Intellectual disability, progressive (HP:0006887)1.90986120
128Deeply set eye (HP:0000490)1.90483758
129Intellectual disability, severe (HP:0010864)1.89658531
130Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.89371660
131Aplasia involving bones of the upper limbs (HP:0009823)1.88731286
132Aplasia of the phalanges of the hand (HP:0009802)1.88731286
133Aplasia involving bones of the extremities (HP:0009825)1.88731286
134Polyphagia (HP:0002591)1.88633230
135Incomplete penetrance (HP:0003829)1.86816416
136Arterial tortuosity (HP:0005116)1.85980776
137Intention tremor (HP:0002080)1.85294748
138Abnormality of macular pigmentation (HP:0008002)1.84904230
139Autism (HP:0000717)1.84723731
140Focal dystonia (HP:0004373)1.83849478
141Retinal dysplasia (HP:0007973)1.83623674
142Dysmetric saccades (HP:0000641)1.81621863
143Type II lissencephaly (HP:0007260)1.81244715
144Lower limb muscle weakness (HP:0007340)1.80563134
145Hemiplegia (HP:0002301)1.79607305
146Gait ataxia (HP:0002066)1.77343657
147Attenuation of retinal blood vessels (HP:0007843)1.77104455
148Abnormal ciliary motility (HP:0012262)1.77036086
149Prolonged QT interval (HP:0001657)1.76302117
150Medial flaring of the eyebrow (HP:0010747)1.74732086
151Ulnar claw (HP:0001178)1.74671527
152Degeneration of the lateral corticospinal tracts (HP:0002314)1.74332323
153Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.74332323
154Abnormality of the 4th metacarpal (HP:0010012)1.73298458
155Limb dystonia (HP:0002451)1.73234398
156Decreased circulating renin level (HP:0003351)1.72065233
157Capillary hemangiomas (HP:0005306)1.71991750
158Cupped ear (HP:0000378)1.71453015

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA45.48307943
2NTRK35.30804368
3CDC42BPA4.13035095
4CASK3.52175418
5TAOK33.46275487
6TNIK3.45428629
7TGFBR23.13451961
8LATS12.88237223
9MAP3K42.76522223
10MAP3K92.75098600
11MARK12.73455724
12MAP2K72.68778079
13RIPK42.58545600
14FRK2.39272493
15NTRK22.07269473
16DAPK22.03852055
17MINK11.95808591
18NUAK11.92866637
19PRPF4B1.84914005
20PNCK1.81693971
21MAPK131.72191254
22DAPK11.67098686
23PLK21.50295271
24PAK61.49575990
25MAP2K41.48525167
26SIK21.46878667
27MAP3K121.41072595
28CDK51.40134601
29KSR11.39365248
30FES1.36888063
31BMPR21.29465885
32NTRK11.29089759
33WNK11.26530507
34CAMK2B1.24726867
35RPS6KA41.17485646
36* CAMK2A1.17278552
37PDGFRA1.16820242
38HCK1.16605137
39EPHA31.15513996
40CAMKK11.14337007
41PRKCG1.12281782
42KSR21.10878996
43SGK21.06821914
44AKT31.06781088
45GRK51.04651338
46SGK4941.03753333
47SGK2231.03753333
48CDK191.02711915
49STK381.02023847
50PRKD31.01871521
51PTK2B0.99013160
52CAMK10.98502849
53CAMKK20.97943408
54MAP3K130.97791721
55DYRK30.94293563
56SGK10.92180365
57OXSR10.92073121
58MAP4K20.87138289
59ARAF0.85043610
60FGR0.82957686
61ROCK10.81868635
62CAMK1G0.80043256
63NEK60.78805256
64MARK20.76163820
65SIK30.75596483
66CAMK2D0.72847737
67UHMK10.71851889
68PRKDC0.71576315
69GRK70.71303672
70SGK30.71053291
71STK110.70723294
72INSRR0.69052941
73CSNK1G30.68443476
74DYRK1A0.67703578
75RAF10.67020232
76DYRK20.65860503
77CSNK1A1L0.65203793
78CDK180.64858160
79ABL10.63025318
80ADRBK10.62555697
81PRKCE0.62228605
82PKN10.61392588
83CSNK1G20.61205233
84CDK150.60970644
85NME10.60545129
86WNK30.59954647
87LCK0.58762901
88CDK140.56499147
89CSNK1G10.56466063
90TRIM280.56465596
91TYRO30.56278047
92PHKG10.55654218
93PHKG20.55654218
94GRK10.54021920
95TAOK20.53790541
96DMPK0.52665596
97MAP3K70.52349437
98CDK11A0.51693392
99CAMK40.51050951
100CDK30.50279371
101PINK10.50114991
102PAK30.49888220
103TNK20.49712710
104TAOK10.47746775
105RPS6KA30.47519855
106MAP3K20.47200383
107BCR0.46719878
108CAMK2G0.45681930
109PRKCH0.45030063
110PRKCZ0.44810249
111FYN0.42981297
112MAP3K60.42189515
113PRKG10.41418872
114BRAF0.40589753
115CCNB10.40295751
116FER0.40077470
117PRKCB0.39575875
118ERBB30.39534578
119PDPK10.38395544
120MAPK100.38300950
121PDK10.38208001
122ADRBK20.37859641
123PRKCQ0.35187429
124PRKACA0.35163033
125ATM0.34658779
126FGFR20.33881506
127PDGFRB0.33515352
128ROCK20.32999354
129PRKACB0.32433628
130CSNK1A10.31126971
131GSK3B0.29552274
132STK390.29435241
133EPHB10.26994009
134CSNK1E0.26423393
135IRAK10.23366060
136CSNK1D0.23205737
137BMPR1B0.21733452
138MAPK140.20731968
139PIK3CA0.20188027

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009005.35646239
2Nicotine addiction_Homo sapiens_hsa050334.60958614
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047233.00755282
4Circadian entrainment_Homo sapiens_hsa047132.96423168
5Glutamatergic synapse_Homo sapiens_hsa047242.92447338
6Long-term potentiation_Homo sapiens_hsa047202.91813078
7Amphetamine addiction_Homo sapiens_hsa050312.74280195
8Morphine addiction_Homo sapiens_hsa050322.73869065
9GABAergic synapse_Homo sapiens_hsa047272.70022054
10Olfactory transduction_Homo sapiens_hsa047402.58062188
11Synaptic vesicle cycle_Homo sapiens_hsa047212.54275016
12Regulation of autophagy_Homo sapiens_hsa041402.37219189
13Salivary secretion_Homo sapiens_hsa049702.33571589
14Dopaminergic synapse_Homo sapiens_hsa047282.21861413
15Taste transduction_Homo sapiens_hsa047422.08194338
16Calcium signaling pathway_Homo sapiens_hsa040201.95227890
17Serotonergic synapse_Homo sapiens_hsa047261.95159966
18Renin secretion_Homo sapiens_hsa049241.92275701
19Insulin secretion_Homo sapiens_hsa049111.90973585
20Cholinergic synapse_Homo sapiens_hsa047251.88254545
21Long-term depression_Homo sapiens_hsa047301.86402642
22Cocaine addiction_Homo sapiens_hsa050301.84659074
23Aldosterone synthesis and secretion_Homo sapiens_hsa049251.78949622
24Oxytocin signaling pathway_Homo sapiens_hsa049211.73518188
25Gastric acid secretion_Homo sapiens_hsa049711.70489046
26Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.62057891
27Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.56546709
28Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.50234714
29Axon guidance_Homo sapiens_hsa043601.43717201
30cAMP signaling pathway_Homo sapiens_hsa040241.42601727
31GnRH signaling pathway_Homo sapiens_hsa049121.37990503
32Collecting duct acid secretion_Homo sapiens_hsa049661.30078015
33Gap junction_Homo sapiens_hsa045401.26257409
34Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.20875661
35N-Glycan biosynthesis_Homo sapiens_hsa005101.20839272
36Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.19236854
37Phosphatidylinositol signaling system_Homo sapiens_hsa040701.14505043
38Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.13860416
39cGMP-PKG signaling pathway_Homo sapiens_hsa040221.11738785
40Type II diabetes mellitus_Homo sapiens_hsa049301.11175288
41Phototransduction_Homo sapiens_hsa047441.10777184
42ErbB signaling pathway_Homo sapiens_hsa040121.07693687
43Vascular smooth muscle contraction_Homo sapiens_hsa042701.04071818
44Melanogenesis_Homo sapiens_hsa049161.02430326
45ABC transporters_Homo sapiens_hsa020101.01955000
46Estrogen signaling pathway_Homo sapiens_hsa049151.01149605
47Glioma_Homo sapiens_hsa052140.99074820
48Pancreatic secretion_Homo sapiens_hsa049720.95469370
49Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.95465735
50Cardiac muscle contraction_Homo sapiens_hsa042600.90518130
51Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.88358571
52Choline metabolism in cancer_Homo sapiens_hsa052310.83450976
53Phospholipase D signaling pathway_Homo sapiens_hsa040720.82942757
54Butanoate metabolism_Homo sapiens_hsa006500.82902221
55Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.79762077
56Dilated cardiomyopathy_Homo sapiens_hsa054140.79083884
57MAPK signaling pathway_Homo sapiens_hsa040100.75395447
58Fatty acid biosynthesis_Homo sapiens_hsa000610.74700465
59Dorso-ventral axis formation_Homo sapiens_hsa043200.74122729
60Adherens junction_Homo sapiens_hsa045200.74069837
61Vibrio cholerae infection_Homo sapiens_hsa051100.73683339
62Nitrogen metabolism_Homo sapiens_hsa009100.73100381
63Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.72384558
64Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.71338133
65Prolactin signaling pathway_Homo sapiens_hsa049170.70095079
66Propanoate metabolism_Homo sapiens_hsa006400.69505401
67Ras signaling pathway_Homo sapiens_hsa040140.69140862
68Sphingolipid metabolism_Homo sapiens_hsa006000.66145563
69RNA degradation_Homo sapiens_hsa030180.65515047
70Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.65464556
71African trypanosomiasis_Homo sapiens_hsa051430.64555950
72Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.64381646
73Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.64195707
74Colorectal cancer_Homo sapiens_hsa052100.64030200
75Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.63021947
76Rap1 signaling pathway_Homo sapiens_hsa040150.62477984
77Oocyte meiosis_Homo sapiens_hsa041140.61387047
78Non-homologous end-joining_Homo sapiens_hsa034500.59540720
79Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.58322582
80Linoleic acid metabolism_Homo sapiens_hsa005910.57950064
81Thyroid hormone synthesis_Homo sapiens_hsa049180.57426162
82Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.55631405
83Wnt signaling pathway_Homo sapiens_hsa043100.55489662
84Circadian rhythm_Homo sapiens_hsa047100.53992988
85Alzheimers disease_Homo sapiens_hsa050100.52115305
86Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.51619366
87Alcoholism_Homo sapiens_hsa050340.51476452
88Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.47910861
89Inositol phosphate metabolism_Homo sapiens_hsa005620.47796040
90VEGF signaling pathway_Homo sapiens_hsa043700.46816730
91Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.46692333
92Sphingolipid signaling pathway_Homo sapiens_hsa040710.46394297
93Glucagon signaling pathway_Homo sapiens_hsa049220.45821145
94Tight junction_Homo sapiens_hsa045300.44955023
95Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.44857173
96Ovarian steroidogenesis_Homo sapiens_hsa049130.43236628
97Neurotrophin signaling pathway_Homo sapiens_hsa047220.39347805
98Type I diabetes mellitus_Homo sapiens_hsa049400.37854929
99Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.37432817
100Chemokine signaling pathway_Homo sapiens_hsa040620.35294718
101Thyroid hormone signaling pathway_Homo sapiens_hsa049190.34793626
102Vitamin B6 metabolism_Homo sapiens_hsa007500.33894593
103Carbohydrate digestion and absorption_Homo sapiens_hsa049730.33109028
104Endometrial cancer_Homo sapiens_hsa052130.30618102
105Longevity regulating pathway - mammal_Homo sapiens_hsa042110.30183471
106Hedgehog signaling pathway_Homo sapiens_hsa043400.30123651
107Hippo signaling pathway_Homo sapiens_hsa043900.29949943
108Non-small cell lung cancer_Homo sapiens_hsa052230.29698826
109Steroid biosynthesis_Homo sapiens_hsa001000.29506518
110Prion diseases_Homo sapiens_hsa050200.28722132
111Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.28604113
112Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.28335602
113Glycerolipid metabolism_Homo sapiens_hsa005610.26852600
114Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.26591001
115Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.25680451
116Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.25292846
117Renal cell carcinoma_Homo sapiens_hsa052110.25153850
118beta-Alanine metabolism_Homo sapiens_hsa004100.24893403
119Regulation of actin cytoskeleton_Homo sapiens_hsa048100.24661156
120AMPK signaling pathway_Homo sapiens_hsa041520.24622446
121Rheumatoid arthritis_Homo sapiens_hsa053230.23388995
122Glycerophospholipid metabolism_Homo sapiens_hsa005640.22699777
123Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.22605748
124Caffeine metabolism_Homo sapiens_hsa002320.22066071
125Ether lipid metabolism_Homo sapiens_hsa005650.21553830
126mTOR signaling pathway_Homo sapiens_hsa041500.20957883
127Basal cell carcinoma_Homo sapiens_hsa052170.20726123
128Bile secretion_Homo sapiens_hsa049760.20025599
129Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.19914209
130Mineral absorption_Homo sapiens_hsa049780.19539507
131Endocytosis_Homo sapiens_hsa041440.19296286

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