LRRC70

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of amino acid transport (GO:0051956)9.63568352
2regulation of glutamate secretion (GO:0014048)7.87356741
3mannose metabolic process (GO:0006013)7.43954957
4negative regulation of neurotransmitter transport (GO:0051589)7.43847215
5serotonin receptor signaling pathway (GO:0007210)7.29968143
6cullin deneddylation (GO:0010388)6.00348654
7pharyngeal system development (GO:0060037)5.71526262
8protein deneddylation (GO:0000338)5.32673159
9positive regulation of organic acid transport (GO:0032892)5.16946602
10regulation of dopamine secretion (GO:0014059)5.13485145
11mature B cell differentiation involved in immune response (GO:0002313)5.01375458
12Peyers patch development (GO:0048541)4.86101884
13mucosal-associated lymphoid tissue development (GO:0048537)4.86101884
14regulation of membrane lipid distribution (GO:0097035)4.74137987
15negative regulation of organic acid transport (GO:0032891)4.71834065
16aggressive behavior (GO:0002118)4.68402332
17regulation of amino acid transport (GO:0051955)4.67361369
18N-glycan processing (GO:0006491)4.64364459
19muscle cell fate commitment (GO:0042693)4.34922071
20branched-chain amino acid catabolic process (GO:0009083)4.33438969
21positive regulation of amine transport (GO:0051954)4.21716957
22positive regulation of granulocyte differentiation (GO:0030854)4.08683715
23negative regulation of protein tyrosine kinase activity (GO:0061099)4.01997698
24negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)3.99682248
25mature B cell differentiation (GO:0002335)3.97008404
26branched-chain amino acid metabolic process (GO:0009081)3.90231320
27definitive hemopoiesis (GO:0060216)3.69281507
28blood vessel maturation (GO:0001955)3.68816493
29ribosome assembly (GO:0042255)3.68544157
30forebrain morphogenesis (GO:0048853)3.64470292
31neutrophil activation involved in immune response (GO:0002283)3.61297131
32regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.60664805
33negative regulation of activin receptor signaling pathway (GO:0032926)3.59267621
34formation of translation preinitiation complex (GO:0001731)3.58713764
35negative regulation of amine transport (GO:0051953)3.57872073
36positive thymic T cell selection (GO:0045059)3.53854864
37immunoglobulin mediated immune response (GO:0016064)3.52418635
38regulation of female receptivity (GO:0045924)3.44896138
39negative regulation of protein oligomerization (GO:0032460)3.43164528
40DNA replication checkpoint (GO:0000076)3.42455864
41early endosome to late endosome transport (GO:0045022)3.38227061
42endothelium development (GO:0003158)3.35115475
43interkinetic nuclear migration (GO:0022027)3.30626159
44intestinal epithelial cell development (GO:0060576)3.29581132
45pathway-restricted SMAD protein phosphorylation (GO:0060389)3.15818877
46positive regulation of B cell differentiation (GO:0045579)3.13650670
47antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.13141089
48pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.05765592
49tryptophan metabolic process (GO:0006568)3.05739175
50B cell mediated immunity (GO:0019724)3.05610295
51negative regulation of erythrocyte differentiation (GO:0045647)3.04654002
52base-excision repair, AP site formation (GO:0006285)2.98685086
53epithelial cell fate commitment (GO:0072148)2.97622513
54RNA destabilization (GO:0050779)2.95255163
55positive regulation of histone H3-K4 methylation (GO:0051571)2.95226418
56female mating behavior (GO:0060180)2.91412556
57regulation of B cell receptor signaling pathway (GO:0050855)2.90651140
58microtubule nucleation (GO:0007020)2.86652280
59pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.84205367
60mast cell degranulation (GO:0043303)2.78393070
61mast cell activation involved in immune response (GO:0002279)2.78393070
62regulation of granulocyte differentiation (GO:0030852)2.77224384
63autophagic vacuole fusion (GO:0000046)2.73700994
64positive regulation of vasculogenesis (GO:2001214)2.70285740
65lipid translocation (GO:0034204)2.69287870
66phospholipid translocation (GO:0045332)2.69287870
67negative regulation of mast cell activation (GO:0033004)2.69042808
68thrombin receptor signaling pathway (GO:0070493)2.67482881
69piRNA metabolic process (GO:0034587)2.64391434
70urogenital system development (GO:0001655)2.63641504
71actin filament capping (GO:0051693)2.63482844
72regulation of catecholamine secretion (GO:0050433)2.62971925
73maintenance of protein location in nucleus (GO:0051457)2.61868215
74Rac protein signal transduction (GO:0016601)2.58169447
75long-term synaptic potentiation (GO:0060291)2.56032916
76regulation of T-helper 1 cell differentiation (GO:0045625)2.54423991
77positive regulation of T cell differentiation in thymus (GO:0033089)2.54103102
78regulation of organic acid transport (GO:0032890)2.51424492
79B cell differentiation (GO:0030183)2.49295511
80regulation of histone H3-K27 methylation (GO:0061085)2.47782206
81positive T cell selection (GO:0043368)2.46694987
82lymphoid progenitor cell differentiation (GO:0002320)2.46661674
83regulation of germinal center formation (GO:0002634)2.44600248
84positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.40615824
85indolalkylamine metabolic process (GO:0006586)2.40580544
86regulation of cilium movement (GO:0003352)2.40516041
87protein import into peroxisome matrix (GO:0016558)2.39546137
88B cell receptor signaling pathway (GO:0050853)2.39070343
89pyrimidine nucleotide catabolic process (GO:0006244)2.37103049
90negative regulation of thymocyte apoptotic process (GO:0070244)2.36361737
91leukocyte degranulation (GO:0043299)2.36295921
92protein sumoylation (GO:0016925)2.35337411
93negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.35031968
94phenylpropanoid metabolic process (GO:0009698)2.34905214
95growth hormone receptor signaling pathway (GO:0060396)2.34365197
96histone H3-K9 methylation (GO:0051567)2.33958176
97positive regulation of catecholamine secretion (GO:0033605)10.5037569
98negative regulation of neurotransmitter secretion (GO:0046929)10.4887333
99positive regulation of amino acid transport (GO:0051957)10.4038415
100phospholipid scrambling (GO:0017121)10.2170063

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.21131388
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.73018682
3CHD7_19251738_ChIP-ChIP_MESCs_Mouse4.17817379
4IGF1R_20145208_ChIP-Seq_DFB_Human3.66849326
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.16224721
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.96305681
7BP1_19119308_ChIP-ChIP_Hs578T_Human2.86390920
8VDR_22108803_ChIP-Seq_LS180_Human2.74522690
9ZNF274_21170338_ChIP-Seq_K562_Hela2.54986388
10HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.51273993
11EWS_26573619_Chip-Seq_HEK293_Human2.28798791
12GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.28073245
13LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.23520602
14GATA1_22025678_ChIP-Seq_K562_Human2.15049418
15PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.13176083
16POU3F2_20337985_ChIP-ChIP_501MEL_Human1.98893999
17LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.98162090
18FUS_26573619_Chip-Seq_HEK293_Human1.92193745
19SCL_19346495_ChIP-Seq_HPC-7_Human1.90098947
20GATA3_26560356_Chip-Seq_TH2_Human1.88309399
21GATA2_21666600_ChIP-Seq_HMVEC_Human1.78361161
22ELF1_17652178_ChIP-ChIP_JURKAT_Human1.75678584
23FLI1_27457419_Chip-Seq_LIVER_Mouse1.74005001
24TP53_22573176_ChIP-Seq_HFKS_Human1.73686104
25NOTCH1_21737748_ChIP-Seq_TLL_Human1.58784741
26GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.55547036
27IRF8_27001747_Chip-Seq_BMDM_Mouse1.53840185
28P300_19829295_ChIP-Seq_ESCs_Human1.53830943
29FOXA1_21572438_ChIP-Seq_LNCaP_Human1.52332933
30GATA3_27048872_Chip-Seq_THYMUS_Human1.50096666
31RUNX_20019798_ChIP-Seq_JUKART_Human1.48404607
32RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.42988521
33GBX2_23144817_ChIP-Seq_PC3_Human1.40444160
34PRDM14_20953172_ChIP-Seq_ESCs_Human1.40269811
35ER_23166858_ChIP-Seq_MCF-7_Human1.39127742
36NANOG_19829295_ChIP-Seq_ESCs_Human1.35463605
37SOX2_19829295_ChIP-Seq_ESCs_Human1.35463605
38ZFP57_27257070_Chip-Seq_ESCs_Mouse1.35137461
39SPI1_23547873_ChIP-Seq_NB4_Human1.34550756
40EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.34505241
41MYB_26560356_Chip-Seq_TH2_Human1.33158535
42IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.32015290
43GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.27854219
44ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.27149109
45RNF2_27304074_Chip-Seq_NSC_Mouse1.25362192
46CDX2_19796622_ChIP-Seq_MESCs_Mouse1.22734799
47POU5F1_16153702_ChIP-ChIP_HESCs_Human1.22450251
48MYC_18940864_ChIP-ChIP_HL60_Human1.21406671
49CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.20555783
50PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.19077376
51FOXP3_21729870_ChIP-Seq_TREG_Human1.18096382
52VDR_23849224_ChIP-Seq_CD4+_Human1.17999904
53HTT_18923047_ChIP-ChIP_STHdh_Human1.17197289
54NRF2_20460467_ChIP-Seq_MEFs_Mouse1.16930998
55NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.16930998
56MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.16713625
57PCGF2_27294783_Chip-Seq_ESCs_Mouse1.16670798
58BMI1_23680149_ChIP-Seq_NPCS_Mouse1.14021381
59TOP2B_26459242_ChIP-Seq_MCF-7_Human1.12799693
60RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.11494887
61SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.11412032
62MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.10878121
63TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.09876058
64GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.08138561
65TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.07692358
66SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.07174463
67EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.06413558
68SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06368252
69Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.05725479
70MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.04941820
71SMAD_19615063_ChIP-ChIP_OVARY_Human1.04867294
72TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.02514040
73TAL1_26923725_Chip-Seq_HPCs_Mouse1.02187655
74HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.01089600
75EGR1_23403033_ChIP-Seq_LIVER_Mouse1.01030238
76FOXA1_25329375_ChIP-Seq_VCAP_Human1.00497264
77FOXA1_27270436_Chip-Seq_PROSTATE_Human1.00497264
78FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.00323948
79IRF1_19129219_ChIP-ChIP_H3396_Human1.00062520
80MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.99984810
81NR3C1_21868756_ChIP-Seq_MCF10A_Human0.98994289
82RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98107780
83VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.97509102
84RUNX1_26923725_Chip-Seq_HPCs_Mouse0.97180210
85P53_22127205_ChIP-Seq_FIBROBLAST_Human0.97171920
86AR_20517297_ChIP-Seq_VCAP_Human0.96184314
87MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.96073583
88GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96026497
89STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.94817750
90ESET_19884257_ChIP-Seq_ESCs_Mouse0.91648630
91TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.91030085
92EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.90984073
93BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.89558891
94EZH2_27294783_Chip-Seq_NPCs_Mouse0.87948609
95ETS1_22383799_ChIP-Seq_G1ME_Mouse0.87627808
96FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.87485180
97VDR_24763502_ChIP-Seq_THP-1_Human0.87202440
98SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.86340251
99IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.86266463
100CBP_20019798_ChIP-Seq_JUKART_Human0.86266463

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008961_abnormal_basal_metabolism5.14400464
2MP0002396_abnormal_hematopoietic_system4.28103511
3MP0002822_catalepsy3.95950469
4MP0003656_abnormal_erythrocyte_physiolo3.89835566
5MP0004808_abnormal_hematopoietic_stem3.68073897
6MP0004782_abnormal_surfactant_physiolog3.58221261
7MP0002234_abnormal_pharynx_morphology3.22607664
8MP0005167_abnormal_blood-brain_barrier2.81170756
9MP0003828_pulmonary_edema2.74803369
10MP0003724_increased_susceptibility_to2.70927277
11MP0002138_abnormal_hepatobiliary_system2.70512428
12MP0009278_abnormal_bone_marrow2.58769362
13MP0001835_abnormal_antigen_presentation2.45343306
14MP0000678_abnormal_parathyroid_gland2.09591553
15MP0006054_spinal_hemorrhage1.93882376
16MP0001545_abnormal_hematopoietic_system1.90944308
17MP0005397_hematopoietic_system_phenotyp1.90944308
18MP0010368_abnormal_lymphatic_system1.77534423
19MP0001800_abnormal_humoral_immune1.76693430
20MP0000613_abnormal_salivary_gland1.75511935
21MP0005000_abnormal_immune_tolerance1.71823665
22MP0005387_immune_system_phenotype1.64931489
23MP0001790_abnormal_immune_system1.64931489
24MP0000465_gastrointestinal_hemorrhage1.62509559
25MP0000681_abnormal_thyroid_gland1.62127919
26MP0002148_abnormal_hypersensitivity_rea1.59610159
27MP0008007_abnormal_cellular_replicative1.56539206
28MP0002735_abnormal_chemical_nociception1.50123264
29MP0006292_abnormal_olfactory_placode1.47937061
30MP0005671_abnormal_response_to1.44888261
31MP0009697_abnormal_copulation1.44421792
32MP0004484_altered_response_of1.43348729
33MP0001873_stomach_inflammation1.42567481
34MP0002405_respiratory_system_inflammati1.41741640
35MP0004215_abnormal_myocardial_fiber1.39535048
36MP0001879_abnormal_lymphatic_vessel1.32598393
37MP0009785_altered_susceptibility_to1.29132317
38MP0002452_abnormal_antigen_presenting1.27195225
39MP0002723_abnormal_immune_serum1.22247773
40MP0000013_abnormal_adipose_tissue1.21452486
41MP0005464_abnormal_platelet_physiology1.20595320
42MP0003436_decreased_susceptibility_to1.18756189
43MP0001819_abnormal_immune_cell1.18349694
44MP0008872_abnormal_physiological_respon1.17802528
45MP0002876_abnormal_thyroid_physiology1.17392942
46MP0009765_abnormal_xenobiotic_induced1.17277085
47MP0002420_abnormal_adaptive_immunity1.16621499
48MP0002166_altered_tumor_susceptibility1.15103671
49MP0000689_abnormal_spleen_morphology1.14840997
50MP0008995_early_reproductive_senescence1.12373799
51MP0005595_abnormal_vascular_smooth1.11582409
52MP0010155_abnormal_intestine_physiology1.11138475
53MP0001664_abnormal_digestion1.07853984
54MP0009764_decreased_sensitivity_to1.06568716
55MP0002398_abnormal_bone_marrow1.06452493
56MP0005166_decreased_susceptibility_to1.06214571
57MP0005389_reproductive_system_phenotype1.02610096
58MP0005220_abnormal_exocrine_pancreas1.01151848
59MP0003866_abnormal_defecation0.98884556
60MP0005645_abnormal_hypothalamus_physiol0.98402257
61MP0000716_abnormal_immune_system0.97099735
62MP0005646_abnormal_pituitary_gland0.96700644
63MP0002160_abnormal_reproductive_system0.94824157
64MP0003868_abnormal_feces_composition0.93999526
65MP0001845_abnormal_inflammatory_respons0.93612230
66MP0004883_abnormal_blood_vessel0.93611919
67MP0000685_abnormal_immune_system0.93530994
68MP0000049_abnormal_middle_ear0.92666087
69MP0002009_preneoplasia0.92497874
70MP0002722_abnormal_immune_system0.91975757
71MP0002419_abnormal_innate_immunity0.91746360
72MP0002006_tumorigenesis0.89369642
73MP0008875_abnormal_xenobiotic_pharmacok0.88923952
74MP0002933_joint_inflammation0.87459878
75MP0003303_peritoneal_inflammation0.87318734
76MP0005025_abnormal_response_to0.85991676
77MP0004147_increased_porphyrin_level0.85778546
78MP0000490_abnormal_crypts_of0.85052309
79MP0003763_abnormal_thymus_physiology0.84843651
80MP0000230_abnormal_systemic_arterial0.82991031
81MP0002249_abnormal_larynx_morphology0.82645226
82MP0008775_abnormal_heart_ventricle0.82422699
83MP0002429_abnormal_blood_cell0.78676594
84MP0000703_abnormal_thymus_morphology0.78307593
85MP0003191_abnormal_cellular_cholesterol0.77116914
86MP0001533_abnormal_skeleton_physiology0.75805232
87MP0000249_abnormal_blood_vessel0.73425412
88MP0001529_abnormal_vocalization0.72809621
89MP0010094_abnormal_chromosome_stability0.72017799
90MP0002136_abnormal_kidney_physiology0.69474861
91MP0008469_abnormal_protein_level0.66111599
92MP0005410_abnormal_fertilization0.65629422
93MP0001986_abnormal_taste_sensitivity0.65046633
94MP0000163_abnormal_cartilage_morphology0.64862558
95MP0004142_abnormal_muscle_tone0.64006554
96MP0001666_abnormal_nutrient_absorption0.61800860
97MP0009643_abnormal_urine_homeostasis0.60063679
98MP0008058_abnormal_DNA_repair0.60048759
99MP0005084_abnormal_gallbladder_morpholo0.59447888
100MP0002277_abnormal_respiratory_mucosa0.59171599

Predicted human phenotypes

RankGene SetZ-score
1Short 1st metacarpal (HP:0010034)5.65475739
2Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)5.65475739
3Absent rod-and cone-mediated responses on ERG (HP:0007688)5.36255779
4Abnormality of the renal collecting system (HP:0004742)5.04336643
5Abnormality of the 1st metacarpal (HP:0010009)5.03051363
6Abnormality of the intrinsic pathway (HP:0010989)4.37274617
7Panhypogammaglobulinemia (HP:0003139)4.30621117
8Acute lymphatic leukemia (HP:0006721)3.99518616
9Stenosis of the external auditory canal (HP:0000402)3.98895359
10Abnormality of B cell number (HP:0010975)3.97915027
11Ketosis (HP:0001946)3.90271130
12Menorrhagia (HP:0000132)3.82358197
13B lymphocytopenia (HP:0010976)3.72238109
14Abnormal rod and cone electroretinograms (HP:0008323)3.61947522
15Fused cervical vertebrae (HP:0002949)3.56792403
16Aplasia/Hypoplasia of the hallux (HP:0008362)3.55227492
17Short phalanx of the thumb (HP:0009660)3.50010601
18Severe combined immunodeficiency (HP:0004430)3.42433671
19Constricted visual fields (HP:0001133)3.38222947
20Short hallux (HP:0010109)3.32642911
21Abnormality of the common coagulation pathway (HP:0010990)3.26154812
22Adactyly (HP:0009776)3.22268640
23Abnormality of the prostate (HP:0008775)3.17188283
24Attenuation of retinal blood vessels (HP:0007843)3.15113264
25Thyroiditis (HP:0100646)3.04361754
26Hypoplasia of the thymus (HP:0000778)3.01980316
27Cerebral edema (HP:0002181)2.99255371
28Epistaxis (HP:0000421)2.93864963
29Absent/shortened dynein arms (HP:0200106)2.92581394
30Dynein arm defect of respiratory motile cilia (HP:0012255)2.92581394
31Agammaglobulinemia (HP:0004432)2.91805732
32Increased hepatocellular lipid droplets (HP:0006565)2.88750073
33Lipid accumulation in hepatocytes (HP:0006561)2.83236751
34Abolished electroretinogram (ERG) (HP:0000550)2.72683195
35Vertebral hypoplasia (HP:0008417)2.72671706
36Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.72671706
37Pancreatitis (HP:0001733)2.66657336
38Autoimmune hemolytic anemia (HP:0001890)2.63284723
39Widely spaced teeth (HP:0000687)2.59683356
40Decreased electroretinogram (ERG) amplitude (HP:0000654)2.55471403
41Elevated erythrocyte sedimentation rate (HP:0003565)2.50546793
42Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.48337405
43Abnormality of the phalanges of the 2nd finger (HP:0009541)2.48329380
44Methylmalonic acidemia (HP:0002912)2.47657702
45Combined immunodeficiency (HP:0005387)2.47042480
46Optic disc pallor (HP:0000543)2.35954313
47Duplicated collecting system (HP:0000081)2.34374607
48Renal Fanconi syndrome (HP:0001994)2.33815736
49Exertional dyspnea (HP:0002875)2.32030825
50Congenital stationary night blindness (HP:0007642)2.31872102
51Eosinophilia (HP:0001880)2.30911740
52Abnormality of cochlea (HP:0000375)2.30825876
53Decreased central vision (HP:0007663)2.24741754
54Lip pit (HP:0100267)2.19064908
55Chronic sinusitis (HP:0011109)2.18862561
56Granulocytopenia (HP:0001913)2.15593985
57Increased intramyocellular lipid droplets (HP:0012240)2.14898180
58Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.14085682
59Hypoproteinemia (HP:0003075)2.13617054
60Abnormality of eosinophils (HP:0001879)2.09982378
61Myositis (HP:0100614)2.09190641
62Ureteral stenosis (HP:0000071)2.03328919
63Morphological abnormality of the middle ear (HP:0008609)2.02872847
64Ureteral obstruction (HP:0006000)2.01788507
65Encephalitis (HP:0002383)1.99174867
66Chorioretinal atrophy (HP:0000533)1.96882379
67Abnormality of the phalanges of the 5th finger (HP:0004213)1.94187352
68Metaphyseal dysplasia (HP:0100255)1.93353230
69Increased muscle lipid content (HP:0009058)1.91586549
70Delayed CNS myelination (HP:0002188)1.91552419
71J-shaped sella turcica (HP:0002680)1.90205180
72Lethargy (HP:0001254)1.88773802
73Meningitis (HP:0001287)1.86955941
74Recurrent fungal infections (HP:0002841)1.82333233
75Broad-based gait (HP:0002136)1.82002736
76Polydipsia (HP:0001959)1.81696729
77Abnormal drinking behavior (HP:0030082)1.81696729
78Abnormality of the heme biosynthetic pathway (HP:0010472)1.79517034
79Stomach cancer (HP:0012126)1.77833303
80Recurrent viral infections (HP:0004429)1.77457958
81Abnormal delayed hypersensitivity skin test (HP:0002963)1.76087273
82Pendular nystagmus (HP:0012043)1.73106205
83Carpal bone hypoplasia (HP:0001498)1.73067071
84Brushfield spots (HP:0001088)1.72983473
85Keratoconjunctivitis (HP:0001096)1.72726200
86Large for gestational age (HP:0001520)1.71223389
87Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.70696675
88Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.70305155
89Autoimmune thrombocytopenia (HP:0001973)1.68902178
90Arterial thrombosis (HP:0004420)1.68704612
91Dyskinesia (HP:0100660)1.68493505
92Abnormality of T cell physiology (HP:0011840)1.68319209
93Prostate neoplasm (HP:0100787)1.68252977
94Abnormality of liposaccharide metabolism (HP:0010968)1.66537678
95Abnormality of glycosphingolipid metabolism (HP:0004343)1.66537678
96Abnormality of glycolipid metabolism (HP:0010969)1.66537678
97Abnormality of male internal genitalia (HP:0000022)1.66159996
98Congenital, generalized hypertrichosis (HP:0004540)1.64126028
99Morphological abnormality of the inner ear (HP:0011390)1.62967295
100Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.62798017

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK35.31019720
2KIT2.74385025
3TIE12.60183067
4BMPR1B2.01496159
5BCKDK12.8574746
6TAOK31.78763076
7CDK81.71247509
8FRK1.57944228
9TGFBR11.54423943
10TEC1.52080281
11TGFBR21.45239795
12FLT31.43714365
13FES1.36100312
14EIF2AK21.30324806
15TRPM71.29085984
16ZAK1.17616811
17GRK11.13592297
18BUB11.12767830
19SYK1.00882084
20MAP4K10.99957512
21WNK40.99048271
22ADRBK20.94576582
23CDK190.90917622
24TXK0.87461273
25SCYL20.76638848
26ABL10.73862593
27ERBB30.73500276
28PINK10.73382031
29CSF1R0.72886794
30ACVR1B0.72614698
31ITK0.72506818
32NUAK10.71569034
33MATK0.70105809
34TLK10.68995353
35IKBKE0.67284048
36MAP4K20.66859691
37VRK10.65324065
38PLK20.63181448
39BRSK20.62888031
40BTK0.62391244
41STK380.61457740
42MAPK130.60602020
43IKBKB0.59834017
44KDR0.59531283
45VRK20.59483103
46TBK10.58058079
47PRKG20.56645458
48CAMKK20.55893545
49CHUK0.55207578
50RIPK40.49953888
51PRKD20.49546304
52HCK0.45668360
53PIK3CG0.44972696
54CLK10.44769929
55CSNK1A1L0.44450278
56ZAP700.43854754
57MAPKAPK50.43750310
58MAP2K60.42834737
59LYN0.42634976
60JAK30.41635141
61LCK0.41113124
62RPS6KA40.40372580
63PRKCE0.40236812
64PRKCD0.38732124
65ILK0.38165169
66PBK0.37491316
67DAPK20.37139943
68INSRR0.35858221
69RPS6KB20.35194443
70MAP3K60.34979712
71TNK20.33272855
72RPS6KA50.33167000
73CDK30.32435107
74ATR0.32337676
75INSR0.31494755
76MKNK10.31029328
77RPS6KA60.30030921
78PRKCQ0.29461338
79RPS6KL10.28533845
80RPS6KC10.28533845
81IRAK10.28173541
82MAPKAPK20.28008801
83MAPKAPK30.27629085
84PRKCH0.26245298
85PIM10.24972164
86CDK90.24730504
87IGF1R0.24044060
88OXSR10.23231147
89CSNK1G10.22998521
90STK110.22322122
91MAP3K140.22159640
92BMPR20.21310956
93CSNK1G30.20441033
94FER0.19945395
95AKT20.19570765
96STK40.19501873
97ABL20.19490235
98PIM20.18790243
99GRK50.17877275
100CAMKK10.16226440

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053104.35056610
2Allograft rejection_Homo sapiens_hsa053304.03926768
3Sulfur relay system_Homo sapiens_hsa041223.89622984
4Intestinal immune network for IgA production_Homo sapiens_hsa046723.51146960
5Autoimmune thyroid disease_Homo sapiens_hsa053203.40902171
6Graft-versus-host disease_Homo sapiens_hsa053323.35486347
7Type I diabetes mellitus_Homo sapiens_hsa049403.31363109
8Propanoate metabolism_Homo sapiens_hsa006402.82308486
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.31896814
10Staphylococcus aureus infection_Homo sapiens_hsa051502.15807148
11Primary immunodeficiency_Homo sapiens_hsa053402.07167272
12Leishmaniasis_Homo sapiens_hsa051402.01631227
13Antigen processing and presentation_Homo sapiens_hsa046121.83697225
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.77196745
15Carbohydrate digestion and absorption_Homo sapiens_hsa049731.73334670
16Systemic lupus erythematosus_Homo sapiens_hsa053221.63648473
17NOD-like receptor signaling pathway_Homo sapiens_hsa046211.56794070
18Rheumatoid arthritis_Homo sapiens_hsa053231.50566661
19Starch and sucrose metabolism_Homo sapiens_hsa005001.46787572
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.46656046
21Hematopoietic cell lineage_Homo sapiens_hsa046401.44725427
22N-Glycan biosynthesis_Homo sapiens_hsa005101.43581473
23Salivary secretion_Homo sapiens_hsa049701.29931947
24Viral myocarditis_Homo sapiens_hsa054161.27419346
25SNARE interactions in vesicular transport_Homo sapiens_hsa041301.21755385
26Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.21611262
27Serotonergic synapse_Homo sapiens_hsa047261.14520267
28B cell receptor signaling pathway_Homo sapiens_hsa046621.14173023
29Transcriptional misregulation in cancer_Homo sapiens_hsa052021.12662877
30Linoleic acid metabolism_Homo sapiens_hsa005911.12149554
31Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.11612395
32Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.11323192
33Olfactory transduction_Homo sapiens_hsa047401.10607962
34Arachidonic acid metabolism_Homo sapiens_hsa005901.07666796
35alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.06674654
36African trypanosomiasis_Homo sapiens_hsa051431.06520849
37Non-homologous end-joining_Homo sapiens_hsa034501.06300039
38Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.02821672
39Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.01523646
40Tuberculosis_Homo sapiens_hsa051520.96416823
41Herpes simplex infection_Homo sapiens_hsa051680.91639095
42Toxoplasmosis_Homo sapiens_hsa051450.91222381
43RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.89595095
44Platelet activation_Homo sapiens_hsa046110.89591286
45Retinol metabolism_Homo sapiens_hsa008300.88350847
46Renin-angiotensin system_Homo sapiens_hsa046140.82625618
47Renin secretion_Homo sapiens_hsa049240.82547762
48Caffeine metabolism_Homo sapiens_hsa002320.82287379
49Jak-STAT signaling pathway_Homo sapiens_hsa046300.81488080
50Chemical carcinogenesis_Homo sapiens_hsa052040.80434601
51Steroid hormone biosynthesis_Homo sapiens_hsa001400.78979293
52Influenza A_Homo sapiens_hsa051640.75274608
53Pentose and glucuronate interconversions_Homo sapiens_hsa000400.74834704
54Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.72966890
55Peroxisome_Homo sapiens_hsa041460.72547248
56Calcium signaling pathway_Homo sapiens_hsa040200.71877754
57Legionellosis_Homo sapiens_hsa051340.71335088
58Malaria_Homo sapiens_hsa051440.70040857
59Ether lipid metabolism_Homo sapiens_hsa005650.68581067
60Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.68132832
61Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.67849177
62Tryptophan metabolism_Homo sapiens_hsa003800.67375811
63Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.65584219
64Phototransduction_Homo sapiens_hsa047440.63591293
65Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.62347303
66Nitrogen metabolism_Homo sapiens_hsa009100.60321157
67ABC transporters_Homo sapiens_hsa020100.54418383
68Base excision repair_Homo sapiens_hsa034100.52436133
69Taste transduction_Homo sapiens_hsa047420.51724461
70Pertussis_Homo sapiens_hsa051330.50832387
71RNA degradation_Homo sapiens_hsa030180.50700750
72Mineral absorption_Homo sapiens_hsa049780.48492034
73Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.45059113
74Other glycan degradation_Homo sapiens_hsa005110.44461721
75Drug metabolism - other enzymes_Homo sapiens_hsa009830.43406247
76cAMP signaling pathway_Homo sapiens_hsa040240.39739116
77Ribosome_Homo sapiens_hsa030100.38191265
78Measles_Homo sapiens_hsa051620.37995362
79Osteoclast differentiation_Homo sapiens_hsa043800.36381230
80Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.34225686
81NF-kappa B signaling pathway_Homo sapiens_hsa040640.33605783
82Folate biosynthesis_Homo sapiens_hsa007900.29970710
83Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.28123781
84Maturity onset diabetes of the young_Homo sapiens_hsa049500.27379486
85Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.26527055
86Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.26202009
87HTLV-I infection_Homo sapiens_hsa051660.25535932
88Morphine addiction_Homo sapiens_hsa050320.24193404
89Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.24057516
90T cell receptor signaling pathway_Homo sapiens_hsa046600.23173825
91Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.22809708
92Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.22486278
93Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.21202644
94Selenocompound metabolism_Homo sapiens_hsa004500.20455382
95Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.19790656
96Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.19440416
97Ovarian steroidogenesis_Homo sapiens_hsa049130.18004205
98TGF-beta signaling pathway_Homo sapiens_hsa043500.15718471
99Long-term depression_Homo sapiens_hsa047300.15432649
100Purine metabolism_Homo sapiens_hsa002300.15075649

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