ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	binding of sperm to zona pellucida (GO:0007339)	9.97980568
2	acrosome reaction (GO:0007340)	9.48516605
3	axonemal dynein complex assembly (GO:0070286)	8.92853107
4	epithelial cilium movement (GO:0003351)	8.61165293
5	male meiosis (GO:0007140)	8.34793531
6	motile cilium assembly (GO:0044458)	8.08907648
7	spermatid development (GO:0007286)	8.04650587
8	single fertilization (GO:0007338)	7.95210716
9	sperm capacitation (GO:0048240)	7.90963496
10	cilium movement (GO:0003341)	7.69438937
11	synaptonemal complex assembly (GO:0007130)	7.30415156
12	spermatid nucleus differentiation (GO:0007289)	7.30369201
13	synaptonemal complex organization (GO:0070193)	7.09460873
14	piRNA metabolic process (GO:0034587)	6.99033251
15	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	6.93387512
16	regulation of cilium movement (GO:0003352)	6.69410919
17	fertilization (GO:0009566)	6.16205530
18	cell recognition (GO:0008037)	5.64365923
19	ventricular system development (GO:0021591)	5.38881518
20	chromosome organization involved in meiosis (GO:0070192)	5.29726050
21	microtubule depolymerization (GO:0007019)	5.27604911
22	calcium ion-dependent exocytosis (GO:0017156)	5.23011615
23	spermatogenesis (GO:0007283)	5.15212174
24	male gamete generation (GO:0048232)	5.13142122
25	organic cation transport (GO:0015695)	5.03230429
26	microtubule severing (GO:0051013)	4.98740509
27	cellular process involved in reproduction in multicellular organism (GO:0022412)	4.89137127
28	DNA methylation involved in gamete generation (GO:0043046)	4.87111692
29	gamete generation (GO:0007276)	4.72681335
30	meiotic nuclear division (GO:0007126)	4.53639817
31	germ cell development (GO:0007281)	4.45999999
32	negative regulation of inclusion body assembly (GO:0090084)	4.14372344
33	male meiosis I (GO:0007141)	4.08411776
34	monoubiquitinated protein deubiquitination (GO:0035520)	4.06325003
35	protein K11-linked deubiquitination (GO:0035871)	3.86396284
36	regulation of microtubule-based movement (GO:0060632)	3.79891040
37	multicellular organismal reproductive process (GO:0048609)	3.71015034
38	centriole assembly (GO:0098534)	3.70950161
39	protein polyglutamylation (GO:0018095)	3.69629328
40	synapsis (GO:0007129)	3.67902842
41	centriole replication (GO:0007099)	3.59717634
42	regulation of inclusion body assembly (GO:0090083)	3.58698307
43	protein localization to cilium (GO:0061512)	3.40777292
44	glycerol ether metabolic process (GO:0006662)	3.40154885
45	positive regulation of inositol phosphate biosynthetic process (GO:0060732)	3.23052065
46	intraciliary transport (GO:0042073)	3.21466691
47	ether metabolic process (GO:0018904)	3.13256962
48	positive regulation of macrophage activation (GO:0043032)	3.11786245
49	meiosis I (GO:0007127)	3.10575550
50	single strand break repair (GO:0000012)	3.09237394
51	cellular component assembly involved in morphogenesis (GO:0010927)	3.07137371
52	cilium organization (GO:0044782)	3.06307811
53	multicellular organismal development (GO:0007275)	3.01461344
54	cilium assembly (GO:0042384)	2.97795802
55	GTP biosynthetic process (GO:0006183)	2.95459029
56	calcium ion import (GO:0070509)	2.94551419
57	peptidyl-lysine dimethylation (GO:0018027)	2.88179741
58	microtubule-based movement (GO:0007018)	2.85323596
59	carnitine transport (GO:0015879)	2.83840866
60	amino-acid betaine transport (GO:0015838)	2.83840866
61	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	2.83437490
62	genitalia morphogenesis (GO:0035112)	2.82947226
63	microtubule polymerization or depolymerization (GO:0031109)	2.82443934
64	carnitine transmembrane transport (GO:1902603)	2.78036379
65	regulation of centriole replication (GO:0046599)	2.76592088
66	chaperone-mediated protein complex assembly (GO:0051131)	2.74658898
67	meiotic cell cycle process (GO:1903046)	2.67883941
68	nucleoside diphosphate phosphorylation (GO:0006165)	2.67680544
69	regulation of inositol phosphate biosynthetic process (GO:0010919)	2.64959811
70	negative regulation of organelle assembly (GO:1902116)	2.64452099
71	cilium morphogenesis (GO:0060271)	2.63156033
72	left/right pattern formation (GO:0060972)	2.57605020
73	UTP biosynthetic process (GO:0006228)	2.56480579
74	left/right axis specification (GO:0070986)	2.56139727
75	lactate metabolic process (GO:0006089)	2.54167432
76	membrane depolarization during action potential (GO:0086010)	2.53619692
77	peptidyl-threonine dephosphorylation (GO:0035970)	2.51024617
78	seminiferous tubule development (GO:0072520)	2.48427411
79	single-organism membrane fusion (GO:0044801)	2.48265750
80	histone H3-K9 methylation (GO:0051567)	2.47984715
81	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	2.46088841
82	meiotic cell cycle (GO:0051321)	2.44837882
83	sexual reproduction (GO:0019953)	2.42624658
84	gene silencing by RNA (GO:0031047)	2.41153820
85	chromosome condensation (GO:0030261)	2.40215480
86	polyol catabolic process (GO:0046174)	2.38632621
87	regulation of spindle checkpoint (GO:0090231)	2.37942556
88	protein kinase C signaling (GO:0070528)	2.37265504
89	regulation of cytokine production involved in inflammatory response (GO:1900015)	2.37052297
90	cell wall macromolecule metabolic process (GO:0044036)	18.3170606
91	cell wall macromolecule catabolic process (GO:0016998)	18.3170606
92	fusion of sperm to egg plasma membrane (GO:0007342)	15.1434284
93	acrosome assembly (GO:0001675)	14.5132210
94	multicellular organism reproduction (GO:0032504)	13.8272087
95	sperm-egg recognition (GO:0035036)	12.3535924
96	cilium or flagellum-dependent cell motility (GO:0001539)	12.2805989
97	plasma membrane fusion (GO:0045026)	11.6163572
98	reproduction (GO:0000003)	11.2936615
99	cell-cell recognition (GO:0009988)	11.0885069
100	sperm motility (GO:0030317)	10.9679006

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	7.15375579
2	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	5.54739794
3	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	3.81792802
4	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.56953385
5	CBX2_27304074_Chip-Seq_ESCs_Mouse	3.05266020
6	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	3.04992750
7	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.95190934
8	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.86767844
9	EZH2_22144423_ChIP-Seq_EOC_Human	2.86222958
10	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.60805994
11	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.55596055
12	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.55068505
13	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	2.25334842
14	PCGF2_27294783_Chip-Seq_NPCs_Mouse	2.23421744
15	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	2.20474998
16	KAP1_22055183_ChIP-Seq_ESCs_Mouse	2.09410247
17	ZNF274_21170338_ChIP-Seq_K562_Hela	2.01841799
18	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.99123320
19	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.97520061
20	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.92529423
21	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.92062615
22	RNF2_27304074_Chip-Seq_NSC_Mouse	1.89238761
23	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.88418612
24	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.85209269
25	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.83730061
26	KDM2B_26808549_Chip-Seq_REH_Human	1.83072776
27	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.80055700
28	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.78235813
29	OCT4_18555785_Chip-Seq_ESCs_Mouse	1.78091645
30	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.76794743
31	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.73569778
32	P300_18555785_Chip-Seq_ESCs_Mouse	1.71628889
33	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.70719558
34	GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse	1.70208886
35	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	1.69286852
36	P53_22387025_ChIP-Seq_ESCs_Mouse	1.67308205
37	VDR_22108803_ChIP-Seq_LS180_Human	1.64538903
38	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.64029997
39	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.63837110
40	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.63061526
41	KLF4_18555785_Chip-Seq_ESCs_Mouse	1.61808407
42	ESRRB_18555785_Chip-Seq_ESCs_Mouse	1.61419659
43	STAT1_17558387_ChIP-Seq_HELA_Human	1.58467498
44	SOX2_18555785_Chip-Seq_ESCs_Mouse	1.57535021
45	RUNX1_27457419_Chip-Seq_LIVER_Mouse	1.56931929
46	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.56585063
47	CTCF_18555785_Chip-Seq_ESCs_Mouse	1.55160836
48	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.53297332
49	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.46308554
50	SMAD1_18555785_Chip-Seq_ESCs_Mouse	1.46235435
51	CBP_20019798_ChIP-Seq_JUKART_Human	1.45822349
52	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.45822349
53	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.44615873
54	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.43068086
55	ELK4_26923725_Chip-Seq_MESODERM_Mouse	1.42112969
56	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	1.41948037
57	NMYC_18555785_Chip-Seq_ESCs_Mouse	1.41825968
58	GATA3_21867929_ChIP-Seq_TH1_Mouse	1.41773393
59	MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.37696911
60	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.37574039
61	ZFX_18555785_Chip-Seq_ESCs_Mouse	1.34252054
62	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.33975308
63	GATA3_21867929_ChIP-Seq_CD8_Mouse	1.33504056
64	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.32600201
65	TAF15_26573619_Chip-Seq_HEK293_Human	1.29976098
66	PU1_27457419_Chip-Seq_LIVER_Mouse	1.29378700
67	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.26557496
68	RUNX1_26923725_Chip-Seq_HPCs_Mouse	1.26061420
69	LUZP1_20508642_ChIP-Seq_ESCs_Mouse	1.24848299
70	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.23714538
71	REST_21632747_ChIP-Seq_MESCs_Mouse	1.21544942
72	GF1_26923725_Chip-Seq_HPCs_Mouse	1.20735778
73	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.20629507
74	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.17159219
75	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.15333090
76	GF1B_26923725_Chip-Seq_HPCs_Mouse	1.12931575
77	ER_23166858_ChIP-Seq_MCF-7_Human	1.09033187
78	SOX9_26525672_Chip-Seq_HEART_Mouse	1.08917703
79	FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.06725564
80	SOX2_22085726_ChIP-Seq_NPCs_Mouse	1.04522024
81	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.03255930
82	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.01326773
83	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.01326773
84	SETDB1_19884257_ChIP-Seq_MESCs_Mouse	1.01217875
85	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.99779973
86	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	0.99594514
87	CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	0.97996853
88	EP300_21415370_ChIP-Seq_HL-1_Mouse	0.96756455
89	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	0.95638239
90	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.94990544
91	FUS_26573619_Chip-Seq_HEK293_Human	0.94868054
92	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.94329165
93	POU3F2_20337985_ChIP-ChIP_501MEL_Human	0.94022181
94	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	0.93974492
95	SPI1_26923725_Chip-Seq_HPCs_Mouse	0.93548571
96	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	0.93135594
97	STAT3_18555785_ChIP-Seq_MESCs_Mouse	0.91852231
98	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	0.90918245
99	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.90486841
100	KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse	0.87493083

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003698_abnormal_male_reproductive	5.92607800
2	MP0008877_abnormal_DNA_methylation	5.55423182
3	MP0001929_abnormal_gametogenesis	5.41687132
4	MP0002653_abnormal_ependyma_morphology	4.01419734
5	MP0002210_abnormal_sex_determination	3.69448094
6	MP0005623_abnormal_meninges_morphology	3.40742885
7	MP0002161_abnormal_fertility/fecundity	3.12177418
8	MP0001145_abnormal_male_reproductive	3.11380408
9	MP0009046_muscle_twitch	3.07916547
10	MP0000653_abnormal_sex_gland	2.80426114
11	MP0005410_abnormal_fertilization	14.1978488
12	MP0008058_abnormal_DNA_repair	1.87945768
13	MP0001984_abnormal_olfaction	1.57284765
14	MP0004233_abnormal_muscle_weight	1.56261696
15	MP0005670_abnormal_white_adipose	1.51736487
16	MP0002102_abnormal_ear_morphology	1.51729064
17	MP0002282_abnormal_trachea_morphology	1.48860170
18	MP0008057_abnormal_DNA_replication	1.24941536
19	MP0002160_abnormal_reproductive_system	1.16328046
20	MP0005647_abnormal_sex_gland	1.09858851
21	MP0009697_abnormal_copulation	1.03022140
22	MP0001765_abnormal_ion_homeostasis	0.99627935
23	MP0002009_preneoplasia	0.98044101
24	MP0002234_abnormal_pharynx_morphology	0.94211468
25	MP0010094_abnormal_chromosome_stability	0.92208965
26	MP0008995_early_reproductive_senescence	0.89413883
27	MP0003880_abnormal_central_pattern	0.89143422
28	MP0001968_abnormal_touch/_nociception	0.88380168
29	MP0002928_abnormal_bile_duct	0.77906846
30	MP0005551_abnormal_eye_electrophysiolog	0.76474627
31	MP0002736_abnormal_nociception_after	0.71689943
32	MP0003787_abnormal_imprinting	0.71247814
33	MP0000427_abnormal_hair_cycle	0.69554742
34	MP0009745_abnormal_behavioral_response	0.68410122
35	MP0004036_abnormal_muscle_relaxation	0.66766515
36	MP0001119_abnormal_female_reproductive	0.65678345
37	MP0003699_abnormal_female_reproductive	0.64838845
38	MP0003786_premature_aging	0.64189408
39	MP0003635_abnormal_synaptic_transmissio	0.62496269
40	MP0002837_dystrophic_cardiac_calcinosis	0.62312440
41	MP0003646_muscle_fatigue	0.61783901
42	MP0005253_abnormal_eye_physiology	0.61171672
43	MP0002735_abnormal_chemical_nociception	0.60677151
44	MP0005389_reproductive_system_phenotype	0.59612098
45	MP0002139_abnormal_hepatobiliary_system	0.59433915
46	MP0002572_abnormal_emotion/affect_behav	0.58481031
47	MP0005409_darkened_coat_color	0.57859756
48	MP0002132_abnormal_respiratory_system	0.55588428
49	MP0006072_abnormal_retinal_apoptosis	0.54343131
50	MP0003633_abnormal_nervous_system	0.54127017
51	MP0008872_abnormal_physiological_respon	0.53504030
52	MP0002064_seizures	0.46368237
53	MP0002557_abnormal_social/conspecific_i	0.45559135
54	MP0005388_respiratory_system_phenotype	0.43994003
55	MP0002133_abnormal_respiratory_system	0.43994003
56	MP0008875_abnormal_xenobiotic_pharmacok	0.42883098
57	MP0004742_abnormal_vestibular_system	0.42487953
58	MP0004133_heterotaxia	0.41912822
59	MP0002971_abnormal_brown_adipose	0.41847110
60	MP0004084_abnormal_cardiac_muscle	0.41316589
61	MP0004145_abnormal_muscle_electrophysio	0.41309369
62	MP0005636_abnormal_mineral_homeostasis	0.40393084
63	MP0001529_abnormal_vocalization	0.39120275
64	MP0004019_abnormal_vitamin_homeostasis	0.38599996
65	MP0003950_abnormal_plasma_membrane	0.38559055
66	MP0002734_abnormal_mechanical_nocicepti	0.37847544
67	MP0005423_abnormal_somatic_nervous	0.37473785
68	MP0003631_nervous_system_phenotype	0.36801923
69	MP0003011_delayed_dark_adaptation	0.36769678
70	MP0001486_abnormal_startle_reflex	0.35079212
71	MP0004859_abnormal_synaptic_plasticity	0.34539602
72	MP0004270_analgesia	0.34120482
73	MP0001324_abnormal_eye_pigmentation	0.32622538
74	MP0009250_abnormal_appendicular_skeleto	0.32539687
75	MP0001293_anophthalmia	0.30645032
76	MP0000462_abnormal_digestive_system	0.30622210
77	MP0009379_abnormal_foot_pigmentation	0.30493806
78	MP0002752_abnormal_somatic_nervous	0.30102058
79	MP0002063_abnormal_learning/memory/cond	0.28877708
80	MP0000647_abnormal_sebaceous_gland	0.28424710
81	MP0004130_abnormal_muscle_cell	0.28177594
82	MP0000432_abnormal_head_morphology	0.27927877
83	MP0002152_abnormal_brain_morphology	0.27613367
84	MP0002233_abnormal_nose_morphology	0.26866945
85	MP0003890_abnormal_embryonic-extraembry	0.25084671
86	MP0004811_abnormal_neuron_physiology	0.24613532
87	MP0005391_vision/eye_phenotype	0.24089798
88	MP0009780_abnormal_chondrocyte_physiolo	0.23859474
89	MP0001440_abnormal_grooming_behavior	0.23658623
90	MP0003861_abnormal_nervous_system	0.23472530
91	MP0004134_abnormal_chest_morphology	0.21836315
92	MP0002229_neurodegeneration	0.21787098
93	MP0006036_abnormal_mitochondrial_physio	0.21154703
94	MP0005195_abnormal_posterior_eye	0.20790068
95	MP0005174_abnormal_tail_pigmentation	0.20761096
96	MP0002269_muscular_atrophy	0.19649248
97	MP0005535_abnormal_body_temperature	0.19438099
98	MP0004808_abnormal_hematopoietic_stem	0.18165200
99	MP0005360_urolithiasis	0.18050134
100	MP0001963_abnormal_hearing_physiology	0.17853114

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormal respiratory motile cilium physiology (HP:0012261)	9.23540387
2	Abnormal ciliary motility (HP:0012262)	8.21095964
3	Abnormal respiratory epithelium morphology (HP:0012253)	7.94728343
4	Abnormal respiratory motile cilium morphology (HP:0005938)	7.94728343
5	Rhinitis (HP:0012384)	7.47427532
6	Chronic bronchitis (HP:0004469)	6.46444338
7	Nasal polyposis (HP:0100582)	6.06089331
8	Abnormality of the nasal mucosa (HP:0000433)	4.94472037
9	Infertility (HP:0000789)	4.92608924
10	Medial flaring of the eyebrow (HP:0010747)	4.39194459
11	Bronchiectasis (HP:0002110)	4.36731332
12	Bronchitis (HP:0012387)	4.28633694
13	Tongue fasciculations (HP:0001308)	4.25881736
14	Nephronophthisis (HP:0000090)	4.05774759
15	Abnormal spermatogenesis (HP:0008669)	3.98184922
16	Muscle fibrillation (HP:0010546)	3.92256182
17	Male infertility (HP:0003251)	3.67055618
18	Recurrent sinusitis (HP:0011108)	3.61285494
19	Azoospermia (HP:0000027)	3.52292083
20	Gait imbalance (HP:0002141)	3.41008810
21	Congenital primary aphakia (HP:0007707)	3.37220864
22	Abnormality of the renal medulla (HP:0100957)	3.07015281
23	Recurrent otitis media (HP:0000403)	3.00212595
24	Nephrogenic diabetes insipidus (HP:0009806)	2.92148773
25	Molar tooth sign on MRI (HP:0002419)	2.87840959
26	Abnormality of midbrain morphology (HP:0002418)	2.87840959
27	Genital tract atresia (HP:0001827)	2.83584346
28	Recurrent bronchitis (HP:0002837)	2.83426599
29	Tubulointerstitial nephritis (HP:0001970)	2.79221558
30	Tubular atrophy (HP:0000092)	2.70060270
31	Abnormality of saccadic eye movements (HP:0000570)	2.63679614
32	Vaginal atresia (HP:0000148)	2.63558437
33	Slow saccadic eye movements (HP:0000514)	2.61847935
34	Chronic sinusitis (HP:0011109)	2.60336042
35	Pancreatic fibrosis (HP:0100732)	2.58081807
36	Poor coordination (HP:0002370)	2.55507005
37	Optic nerve hypoplasia (HP:0000609)	2.53177842
38	Tubulointerstitial abnormality (HP:0001969)	2.49318676
39	Microglossia (HP:0000171)	2.39738187
40	Facial cleft (HP:0002006)	2.29168413
41	Impaired smooth pursuit (HP:0007772)	2.23642301
42	Congenital hepatic fibrosis (HP:0002612)	2.21394495
43	Median cleft lip (HP:0000161)	2.20229814
44	Tubulointerstitial fibrosis (HP:0005576)	2.15389911
45	Aplasia/Hypoplasia of the lens (HP:0008063)	2.13752174
46	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.09305119
47	Postaxial foot polydactyly (HP:0001830)	2.08812738
48	Spontaneous abortion (HP:0005268)	2.06860929
49	Postaxial hand polydactyly (HP:0001162)	2.03264933
50	Aplasia/Hypoplasia affecting the fundus (HP:0008057)	2.01449443
51	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	13.7620414
52	Absent/shortened dynein arms (HP:0200106)	11.2155499
53	Dynein arm defect of respiratory motile cilia (HP:0012255)	11.2155499
54	Stage 5 chronic kidney disease (HP:0003774)	1.98416613
55	Abnormality of ocular smooth pursuit (HP:0000617)	1.97512596
56	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.92946837
57	Abnormality of the renal cortex (HP:0011035)	1.88008651
58	Decreased central vision (HP:0007663)	1.85203044
59	Chronic hepatic failure (HP:0100626)	1.85091973
60	Limb ataxia (HP:0002070)	1.82064361
61	Fibular hypoplasia (HP:0003038)	1.69193151
62	Polydipsia (HP:0001959)	1.69125011
63	Abnormal drinking behavior (HP:0030082)	1.69125011
64	Short ribs (HP:0000773)	1.62039577
65	Abnormality of the dental root (HP:0006486)	1.61576279
66	Taurodontia (HP:0000679)	1.61576279
67	Abnormality of permanent molar morphology (HP:0011071)	1.61576279
68	Dental crowding (HP:0000678)	1.61112940
69	Absent frontal sinuses (HP:0002688)	1.59291306
70	Abnormality of molar (HP:0011077)	1.57048878
71	Abnormality of molar morphology (HP:0011070)	1.57048878
72	Abnormality of renal excretion (HP:0011036)	1.56307276
73	Renal dysplasia (HP:0000110)	1.54625914
74	J-shaped sella turcica (HP:0002680)	1.54571014
75	True hermaphroditism (HP:0010459)	1.50534024
76	Impulsivity (HP:0100710)	1.45999068
77	Supernumerary spleens (HP:0009799)	1.45744502
78	Broad foot (HP:0001769)	1.43858825
79	Pancreatic cysts (HP:0001737)	1.43401116
80	Absent eyebrow (HP:0002223)	1.43233652
81	Abnormality of the dental pulp (HP:0006479)	1.42700194
82	Cystic liver disease (HP:0006706)	1.41026111
83	Oculomotor apraxia (HP:0000657)	1.38466972
84	Chronic otitis media (HP:0000389)	1.38184596
85	Occipital encephalocele (HP:0002085)	1.36906924
86	Bile duct proliferation (HP:0001408)	1.36583725
87	Abnormal biliary tract physiology (HP:0012439)	1.36583725
88	Nephroblastoma (Wilms tumor) (HP:0002667)	1.35866979
89	Hypodontia (HP:0000668)	1.30873477
90	Cone-rod dystrophy (HP:0000548)	1.30251111
91	Papillary thyroid carcinoma (HP:0002895)	1.28182503
92	Astigmatism (HP:0000483)	1.26455102
93	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.25652490
94	Embryonal renal neoplasm (HP:0011794)	1.24269001
95	Metaphyseal dysplasia (HP:0100255)	1.22023546
96	Hypocalcemia (HP:0002901)	1.21543951
97	Short thorax (HP:0010306)	1.20890996
98	Hypoplasia of the capital femoral epiphysis (HP:0003090)	1.20236511
99	Polycystic ovaries (HP:0000147)	1.19117370
100	Nephropathy (HP:0000112)	1.18144956

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PDK4	8.88613117
2	PDK3	8.88613117
3	PDK2	5.71810813
4	STK39	3.01957482
5	PTK2B	2.70126651
6	TESK1	2.68833708
7	WNK4	2.59298256
8	PRKD3	2.31985269
9	BRSK2	2.30526676
10	LMTK2	2.18940925
11	STK38L	2.06575489
12	STK38	1.68217493
13	MAP2K7	1.68002255
14	ICK	1.43868261
15	SCYL2	1.20558769
16	WEE1	1.12021335
17	MAP3K4	1.10108026
18	ACVR1B	1.01797440
19	CHEK2	0.99224008
20	PDK1	0.99066110
21	AKT3	0.98456607
22	IRAK1	0.98404913
23	BRSK1	0.97925869
24	PNCK	0.93585562
25	MAP2K6	0.88353632
26	TYRO3	0.75060744
27	PLK4	0.74936998
28	WNK1	0.73171564
29	OXSR1	0.70190056
30	MARK3	0.68801736
31	PKN1	0.67362899
32	CDK12	0.66405471
33	MAP2K4	0.62781856
34	MST1R	0.59628981
35	CCNB1	0.58413745
36	RIPK4	0.58300753
37	ZAP70	0.51526174
38	NEK2	0.51291190
39	YES1	0.50969433
40	PDGFRB	0.50739581
41	CDC7	0.50555871
42	BCR	0.50234658
43	CHEK1	0.45625386
44	CASK	0.42070460
45	PRKCG	0.38803170
46	MINK1	0.38789233
47	TTK	0.37661194
48	PDPK1	0.37317456
49	PRKG2	0.35992358
50	NEK6	0.35888424
51	IRAK2	0.35844306
52	PIK3CG	0.35659462
53	MUSK	0.35560222
54	PLK1	0.31688615
55	ATM	0.31585634
56	STK11	0.30159713
57	DYRK3	0.29522578
58	FES	0.29466071
59	MARK1	0.28835920
60	MAPK15	0.28095526
61	TRPM7	0.28046329
62	DYRK1B	0.27237501
63	ADRBK2	0.26249074
64	RIPK1	0.26024231
65	EPHA4	0.25287325
66	ATR	0.23759393
67	CAMK2A	0.23612369
68	PRKG1	0.23147930
69	CDK3	0.22828838
70	PASK	0.22417612
71	CSNK2A2	0.21326106
72	CDK6	0.20944319
73	STK3	0.19542810
74	PRKCQ	0.18969708
75	NTRK2	0.17259382
76	STK16	0.17222148
77	GRK7	0.15950500
78	PRKCZ	0.13483152
79	CAMKK1	0.12699158
80	CDK5	0.12532131
81	PRKDC	0.11782835
82	CSNK2A1	0.11456149
83	RPS6KB1	0.11414287
84	EGFR	0.10389148
85	PRKCD	0.10368321
86	MAPK10	0.10196892
87	PAK1	0.09594109
88	PRKACA	0.09368776
89	CDK15	0.09212320
90	PRKACG	0.08510303
91	GRK1	0.08455125
92	CDK18	0.08177993
93	PRKCA	0.08153555
94	NTRK3	0.07645642
95	PRKCH	0.07386057
96	AURKA	0.07199386
97	CDK1	0.06588923
98	GSK3B	0.06179989
99	PRKCB	0.05795695
100	CDK11A	0.04753956

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	4.65997602
2	Pentose phosphate pathway_Homo sapiens_hsa00030	3.97170036
3	Basal transcription factors_Homo sapiens_hsa03022	3.93822627
4	Propanoate metabolism_Homo sapiens_hsa00640	3.27227014
5	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	3.23322524
6	Vitamin B6 metabolism_Homo sapiens_hsa00750	2.93633279
7	Pyruvate metabolism_Homo sapiens_hsa00620	2.93609429
8	Glycosaminoglycan degradation_Homo sapiens_hsa00531	2.86655433
9	Fatty acid biosynthesis_Homo sapiens_hsa00061	2.68544040
10	Renin-angiotensin system_Homo sapiens_hsa04614	2.44783903
11	Fanconi anemia pathway_Homo sapiens_hsa03460	2.33175043
12	Huntingtons disease_Homo sapiens_hsa05016	2.23361657
13	Glucagon signaling pathway_Homo sapiens_hsa04922	2.13855929
14	Linoleic acid metabolism_Homo sapiens_hsa00591	1.97997618
15	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.95937870
16	Oocyte meiosis_Homo sapiens_hsa04114	1.69269749
17	Glycerolipid metabolism_Homo sapiens_hsa00561	1.68589912
18	Mineral absorption_Homo sapiens_hsa04978	1.62716757
19	Carbon metabolism_Homo sapiens_hsa01200	1.52864155
20	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.50587006
21	Cardiac muscle contraction_Homo sapiens_hsa04260	1.50566165
22	Amphetamine addiction_Homo sapiens_hsa05031	1.38144681
23	PPAR signaling pathway_Homo sapiens_hsa03320	1.35871756
24	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.35761027
25	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.24233155
26	Homologous recombination_Homo sapiens_hsa03440	1.23785875
27	Collecting duct acid secretion_Homo sapiens_hsa04966	1.21842765
28	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	1.21600347
29	Renin secretion_Homo sapiens_hsa04924	1.21379946
30	Glycerophospholipid metabolism_Homo sapiens_hsa00564	1.17870907
31	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.16643258
32	Ether lipid metabolism_Homo sapiens_hsa00565	1.16570638
33	Lysine degradation_Homo sapiens_hsa00310	1.11051769
34	Purine metabolism_Homo sapiens_hsa00230	1.04029504
35	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.99093819
36	Calcium signaling pathway_Homo sapiens_hsa04020	0.98552140
37	Taste transduction_Homo sapiens_hsa04742	0.97191240
38	Selenocompound metabolism_Homo sapiens_hsa00450	0.92714946
39	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.91673854
40	Nicotine addiction_Homo sapiens_hsa05033	0.89360580
41	Sulfur metabolism_Homo sapiens_hsa00920	0.89056511
42	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.87473858
43	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.86695039
44	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.84546889
45	Fat digestion and absorption_Homo sapiens_hsa04975	0.83014618
46	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.81434134
47	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.80233259
48	Insulin secretion_Homo sapiens_hsa04911	0.80208797
49	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.79579405
50	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.73473991
51	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.72592290
52	Fatty acid degradation_Homo sapiens_hsa00071	0.70902246
53	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.68674044
54	Glutathione metabolism_Homo sapiens_hsa00480	0.66496738
55	Circadian entrainment_Homo sapiens_hsa04713	0.63674044
56	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.63669073
57	ABC transporters_Homo sapiens_hsa02010	0.62254988
58	Fatty acid metabolism_Homo sapiens_hsa01212	0.60854854
59	Long-term potentiation_Homo sapiens_hsa04720	0.60798553
60	Olfactory transduction_Homo sapiens_hsa04740	0.59998496
61	Protein digestion and absorption_Homo sapiens_hsa04974	0.58245814
62	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.57920996
63	RNA transport_Homo sapiens_hsa03013	0.56356200
64	Chemical carcinogenesis_Homo sapiens_hsa05204	0.55958215
65	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.55603102
66	Bile secretion_Homo sapiens_hsa04976	0.55462029
67	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.54246122
68	Pancreatic secretion_Homo sapiens_hsa04972	0.53955934
69	Metabolic pathways_Homo sapiens_hsa01100	0.53563419
70	mRNA surveillance pathway_Homo sapiens_hsa03015	0.53218551
71	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.53068899
72	Morphine addiction_Homo sapiens_hsa05032	0.51215725
73	Glutamatergic synapse_Homo sapiens_hsa04724	0.48352864
74	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.48061100
75	Non-homologous end-joining_Homo sapiens_hsa03450	0.48024462
76	Salivary secretion_Homo sapiens_hsa04970	0.46629283
77	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.46276552
78	Antigen processing and presentation_Homo sapiens_hsa04612	0.46070793
79	Gastric acid secretion_Homo sapiens_hsa04971	0.45416916
80	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.43591188
81	Tight junction_Homo sapiens_hsa04530	0.43510438
82	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.42838274
83	Estrogen signaling pathway_Homo sapiens_hsa04915	0.41003588
84	Dopaminergic synapse_Homo sapiens_hsa04728	0.38688220
85	Cocaine addiction_Homo sapiens_hsa05030	0.37956709
86	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.37440846
87	cAMP signaling pathway_Homo sapiens_hsa04024	0.35454595
88	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.35244667
89	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.34593899
90	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.33983040
91	Graft-versus-host disease_Homo sapiens_hsa05332	0.33102442
92	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.32731617
93	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.31900657
94	Salmonella infection_Homo sapiens_hsa05132	0.30339563
95	Oxidative phosphorylation_Homo sapiens_hsa00190	0.28676942
96	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.25125389
97	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.22019815
98	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.21409472
99	Endocytosis_Homo sapiens_hsa04144	0.18723696
100	Complement and coagulation cascades_Homo sapiens_hsa04610	0.17744015

LRRC72

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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