LRRC74A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1reproduction (GO:0000003)9.95953725
2epithelial cilium movement (GO:0003351)9.86405888
3axonemal dynein complex assembly (GO:0070286)9.76809272
4spermatid development (GO:0007286)9.58200586
5motile cilium assembly (GO:0044458)9.51236912
6cilium or flagellum-dependent cell motility (GO:0001539)9.35637992
7protein targeting to Golgi (GO:0000042)8.46184042
8regulation of cilium movement (GO:0003352)8.29789435
9establishment of protein localization to Golgi (GO:0072600)8.20732924
10cilium movement (GO:0003341)7.97957621
11retrograde transport, vesicle recycling within Golgi (GO:0000301)7.91095299
12single fertilization (GO:0007338)7.59652975
13epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.47931521
14rRNA methylation (GO:0031167)7.45536716
15sperm capacitation (GO:0048240)7.19493182
16male meiosis (GO:0007140)6.94667637
17synaptonemal complex organization (GO:0070193)6.92747843
18synaptonemal complex assembly (GO:0007130)6.84977849
19negative regulation of inclusion body assembly (GO:0090084)6.73568796
20piRNA metabolic process (GO:0034587)6.72197908
21phosphatidylethanolamine biosynthetic process (GO:0006646)6.64163664
22centriole replication (GO:0007099)6.58484266
23spermatogenesis (GO:0007283)6.56055483
24microtubule depolymerization (GO:0007019)6.55756535
25male gamete generation (GO:0048232)6.53658206
26response to pheromone (GO:0019236)6.49759699
27organic cation transport (GO:0015695)6.37330763
28fertilization (GO:0009566)6.32775618
29rRNA modification (GO:0000154)6.19946703
30phosphatidylethanolamine metabolic process (GO:0046337)6.12838903
31protein localization to Golgi apparatus (GO:0034067)6.06957066
32gamete generation (GO:0007276)6.01123474
33regulation of inclusion body assembly (GO:0090083)5.69067348
34spermatid nucleus differentiation (GO:0007289)5.68512489
35calcium ion-dependent exocytosis (GO:0017156)5.64382098
36regulation of centriole replication (GO:0046599)5.49015391
37cellular process involved in reproduction in multicellular organism (GO:0022412)5.34120079
38germ cell development (GO:0007281)5.31301600
39cell recognition (GO:0008037)5.18304077
40ventricular system development (GO:0021591)5.08434457
41glomerular visceral epithelial cell development (GO:0072015)4.99919845
42regulation of Rab GTPase activity (GO:0032313)4.97434033
43positive regulation of Rab GTPase activity (GO:0032851)4.97434033
44glycerol ether metabolic process (GO:0006662)4.96060285
45regulation of microtubule-based movement (GO:0060632)4.88867302
46chromosome condensation (GO:0030261)4.85038452
47microtubule severing (GO:0051013)4.74365994
48multicellular organismal reproductive process (GO:0048609)4.72971985
49chromosome organization involved in meiosis (GO:0070192)4.67398323
50glomerular epithelial cell development (GO:0072310)4.65880105
51ether metabolic process (GO:0018904)4.58613180
52DNA packaging (GO:0006323)4.57564229
53cellular ketone body metabolic process (GO:0046950)4.53192519
54male meiosis I (GO:0007141)4.43157280
55DNA methylation involved in gamete generation (GO:0043046)4.36077395
56multicellular organismal movement (GO:0050879)4.35277430
57musculoskeletal movement (GO:0050881)4.35277430
58sexual reproduction (GO:0019953)4.35264518
59seminiferous tubule development (GO:0072520)4.33900574
60regulation of transcription involved in cell fate commitment (GO:0060850)4.17220563
61single strand break repair (GO:0000012)4.16118817
62microtubule nucleation (GO:0007020)4.14683826
63meiotic nuclear division (GO:0007126)4.10949273
64chaperone-mediated protein complex assembly (GO:0051131)4.05851694
65left/right pattern formation (GO:0060972)4.00664721
66ketone body metabolic process (GO:1902224)3.97811856
67membrane protein intracellular domain proteolysis (GO:0031293)3.93280103
68nuclear pore complex assembly (GO:0051292)3.82387657
69multicellular organismal development (GO:0007275)3.81184458
70protein K11-linked deubiquitination (GO:0035871)3.69488040
71antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.62280577
72monoubiquitinated protein deubiquitination (GO:0035520)3.60518804
73Golgi to endosome transport (GO:0006895)3.59130289
74sequestering of actin monomers (GO:0042989)3.54206526
75meiosis I (GO:0007127)3.52943453
76genitalia morphogenesis (GO:0035112)3.48616356
77protein polyglutamylation (GO:0018095)3.46363542
78microtubule polymerization or depolymerization (GO:0031109)3.40201572
79intra-Golgi vesicle-mediated transport (GO:0006891)3.22071275
80regulation of spindle checkpoint (GO:0090231)3.21096918
81response to acidic pH (GO:0010447)3.18039556
82pore complex assembly (GO:0046931)3.15466593
83cellular response to pH (GO:0071467)3.13980983
84meiotic cell cycle (GO:0051321)3.11705110
85protein localization to cilium (GO:0061512)3.11094488
86polyol catabolic process (GO:0046174)3.10664534
87amino-acid betaine transport (GO:0015838)3.09378606
88carnitine transport (GO:0015879)3.09378606
89protein refolding (GO:0042026)3.08512929
90nucleus organization (GO:0006997)3.04738362
91glycolytic process (GO:0006096)3.04443708
92regulation of T-helper 2 cell differentiation (GO:0045628)3.03739138
93peptidyl-threonine dephosphorylation (GO:0035970)3.00914601
94alditol metabolic process (GO:0019400)2.99490772
95protein depolymerization (GO:0051261)2.97765471
96nucleoside diphosphate phosphorylation (GO:0006165)2.97360693
97homeostasis of number of cells within a tissue (GO:0048873)2.96609514
98positive regulation of macrophage activation (GO:0043032)2.96468391
99carnitine transmembrane transport (GO:1902603)2.92201267
100negative regulation of Rho protein signal transduction (GO:0035024)2.91414415
101coenzyme catabolic process (GO:0009109)2.88708005
102mitotic sister chromatid cohesion (GO:0007064)2.85419037
103cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.84563977
104interferon-gamma secretion (GO:0072643)2.84097078
105cilium organization (GO:0044782)2.83361959
106GTP biosynthetic process (GO:0006183)2.82730779
107positive regulation of guanylate cyclase activity (GO:0031284)2.79532445
108cerebral cortex neuron differentiation (GO:0021895)2.79113152
109peptide catabolic process (GO:0043171)2.78745412
110nuclear pore organization (GO:0006999)2.75317659
111regulation of interleukin-13 production (GO:0032656)2.74923856
112microtubule-based movement (GO:0007018)2.73949337
113histone H3-K9 demethylation (GO:0033169)2.73797521
114cilium assembly (GO:0042384)2.73563279
115synapsis (GO:0007129)2.73236506
116cellular component assembly involved in morphogenesis (GO:0010927)2.72937994
117receptor recycling (GO:0001881)2.71903480
118peptidyl-glutamic acid modification (GO:0018200)2.70492597
119centriole assembly (GO:0098534)2.70074427
120cilium morphogenesis (GO:0060271)2.69862691
121RNA methylation (GO:0001510)2.68235570
122intraciliary transport (GO:0042073)2.65924215
123meiotic cell cycle process (GO:1903046)2.65208446
124RNA localization (GO:0006403)2.62383420
125axoneme assembly (GO:0035082)2.60893293
126polyamine biosynthetic process (GO:0006596)2.57061003
127glycerol metabolic process (GO:0006071)2.55284254
128lactate metabolic process (GO:0006089)2.54874167
129chromatin silencing (GO:0006342)2.53317435
130regulation of cilium assembly (GO:1902017)2.52632606
131UTP biosynthetic process (GO:0006228)2.52017020
132negative regulation of organelle assembly (GO:1902116)2.45095777
133gene silencing by RNA (GO:0031047)2.43020684
134RNA destabilization (GO:0050779)2.41169931
135cell wall macromolecule metabolic process (GO:0044036)14.5282519
136cell wall macromolecule catabolic process (GO:0016998)14.5282519
137fusion of sperm to egg plasma membrane (GO:0007342)14.2972680
138sperm motility (GO:0030317)13.6979557
139acrosome assembly (GO:0001675)12.1635428
140acrosome reaction (GO:0007340)11.9692536
141sperm-egg recognition (GO:0035036)11.8879862
142multicellular organism reproduction (GO:0032504)11.5615064
143plasma membrane fusion (GO:0045026)10.9044331
144binding of sperm to zona pellucida (GO:0007339)10.6583058
145cell-cell recognition (GO:0009988)10.6479721

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.42343333
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.75715736
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.14267413
4EZH2_22144423_ChIP-Seq_EOC_Human3.87865339
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.80697235
6BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.38245774
7MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.37551594
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.16273590
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.10256917
10PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.88802722
11STAT6_21828071_ChIP-Seq_BEAS2B_Human2.57907388
12VDR_22108803_ChIP-Seq_LS180_Human2.32677811
13FLI1_27457419_Chip-Seq_LIVER_Mouse2.22264946
14CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.19611838
15CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.15806900
16VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.15325748
17ZNF274_21170338_ChIP-Seq_K562_Hela2.08516128
18CTBP1_25329375_ChIP-Seq_LNCAP_Human2.08334741
19FUS_26573619_Chip-Seq_HEK293_Human2.06612127
20GATA1_26923725_Chip-Seq_HPCs_Mouse2.03041797
21EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.02885091
22KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.95924108
23ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.88883792
24PCGF2_27294783_Chip-Seq_ESCs_Mouse1.88831726
25DROSHA_22980978_ChIP-Seq_HELA_Human1.86302642
26TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.79999662
27RAC3_21632823_ChIP-Seq_H3396_Human1.79468910
28ELK4_26923725_Chip-Seq_MESODERM_Mouse1.74807984
29GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.74669658
30STAT1_17558387_ChIP-Seq_HELA_Human1.73776933
31CBX2_27304074_Chip-Seq_ESCs_Mouse1.72876077
32ELF1_20517297_ChIP-Seq_JURKAT_Human1.71400193
33MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.67437843
34RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.66026716
35EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.64112413
36FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.63834491
37KAP1_22055183_ChIP-Seq_ESCs_Mouse1.63672316
38ERA_21632823_ChIP-Seq_H3396_Human1.63600596
39GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.62608134
40MYC_19829295_ChIP-Seq_ESCs_Human1.60946584
41UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.59101602
42KDM2B_26808549_Chip-Seq_REH_Human1.59010725
43SOX2_22085726_ChIP-Seq_NPCs_Mouse1.58706326
44GATA3_21867929_ChIP-Seq_CD8_Mouse1.56993831
45NANOG_20526341_ChIP-Seq_ESCs_Human1.56156293
46SMAD4_21741376_ChIP-Seq_EPCs_Human1.55716763
47RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.55136128
48TAL1_26923725_Chip-Seq_HPCs_Mouse1.54368356
49WDR5_24793694_ChIP-Seq_LNCAP_Human1.54201580
50ER_23166858_ChIP-Seq_MCF-7_Human1.53236313
51HNFA_21074721_ChIP-Seq_CACO-2_Human1.51679754
52TAF2_19829295_ChIP-Seq_ESCs_Human1.51672604
53BCL6_27268052_Chip-Seq_Bcells_Human1.51500973
54SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.50013753
55CBX2_22325352_ChIP-Seq_293T-Rex_Human1.48734693
56RBPJ_21746931_ChIP-Seq_IB4_Human1.48646307
57ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.48183056
58ARNT_22903824_ChIP-Seq_MCF-7_Human1.45661528
59CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.44121754
60CTCF_27219007_Chip-Seq_Bcells_Human1.42606399
61PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.41765431
62ETV1_20927104_ChIP-Seq_GIST48_Human1.41717791
63CBP_20019798_ChIP-Seq_JUKART_Human1.41053504
64IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.41053504
65TDRD3_21172665_ChIP-Seq_MCF-7_Human1.38662420
66OCT4_20526341_ChIP-Seq_ESCs_Human1.37946349
67LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.37011462
68AUTS2_25519132_ChIP-Seq_293T-REX_Human1.35405471
69SMC4_20622854_ChIP-Seq_HELA_Human1.35348987
70AR_25329375_ChIP-Seq_VCAP_Human1.34677460
71SMAD3_21741376_ChIP-Seq_EPCs_Human1.34348269
72NFE2_27457419_Chip-Seq_LIVER_Mouse1.34082162
73PCGF2_27294783_Chip-Seq_NPCs_Mouse1.34060907
74BCOR_27268052_Chip-Seq_Bcells_Human1.33610322
75TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.33028070
76FLI1_21867929_ChIP-Seq_TH2_Mouse1.31912608
77TP63_22573176_ChIP-Seq_HFKS_Human1.31555788
78GATA3_21867929_ChIP-Seq_TH1_Mouse1.31273978
79PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.30523580
80REST_21632747_ChIP-Seq_MESCs_Mouse1.29720746
81FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.29686833
82P53_21459846_ChIP-Seq_SAOS-2_Human1.29381602
83CTCF_20526341_ChIP-Seq_ESCs_Human1.28572423
84CTBP2_25329375_ChIP-Seq_LNCAP_Human1.27871149
85TBL1_22424771_ChIP-Seq_293T_Human1.27661823
86PHF8_20622853_ChIP-Seq_HELA_Human1.26937979
87SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.26454001
88ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.26258610
89TP53_18474530_ChIP-ChIP_U2OS_Human1.25997418
90MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.25965821
91P300_19829295_ChIP-Seq_ESCs_Human1.25837095
92SUZ12_27294783_Chip-Seq_NPCs_Mouse1.25659814
93E2F1_20622854_ChIP-Seq_HELA_Human1.24788743
94PHF8_20622854_ChIP-Seq_HELA_Human1.24582686
95ETV2_25802403_ChIP-Seq_MESCs_Mouse1.24350142
96TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23718305
97RUNX_20019798_ChIP-Seq_JUKART_Human1.23667349
98GATA6_21074721_ChIP-Seq_CACO-2_Human1.23250758
99P68_20966046_ChIP-Seq_HELA_Human1.23113185
100SMAD3_21741376_ChIP-Seq_ESCs_Human1.22621551
101GF1_26923725_Chip-Seq_HPCs_Mouse1.21961706
102CEBPB_22108803_ChIP-Seq_LS180_Human1.20555830
103GATA3_21878914_ChIP-Seq_MCF-7_Human1.19734437
104ZFP57_27257070_Chip-Seq_ESCs_Mouse1.18493141
105CRX_20693478_ChIP-Seq_RETINA_Mouse1.17777793
106CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.17413708
107P300_27268052_Chip-Seq_Bcells_Human1.16852134
108GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.15782044
109NANOG_18555785_Chip-Seq_ESCs_Mouse1.15421847
110VDR_24787735_ChIP-Seq_THP-1_Human1.14937387
111NFYA_21822215_ChIP-Seq_K562_Human1.14937219
112PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.14152643
113PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.13155753
114SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.13098828
115RAD21_21589869_ChIP-Seq_MESCs_Mouse1.12815593
116EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.12151309
117SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.11933556
118TOP2B_26459242_ChIP-Seq_MCF-7_Human1.11709091
119LXR_22292898_ChIP-Seq_THP-1_Human1.11523242
120RUNX1_26923725_Chip-Seq_HPCs_Mouse1.11466704
121P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.10617078
122SPI1_26923725_Chip-Seq_HPCs_Mouse1.10425541
123CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10343938
124TAF15_26573619_Chip-Seq_HEK293_Human1.09780953
125STAT3_23295773_ChIP-Seq_U87_Human1.09318872
126TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09287424
127POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.09287424
128CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.09163399
129OCT4_18555785_Chip-Seq_ESCs_Mouse1.08014342
130SMRT_27268052_Chip-Seq_Bcells_Human1.07817209
131SMAD4_21741376_ChIP-Seq_HESCs_Human1.07636696
132KLF5_20875108_ChIP-Seq_MESCs_Mouse1.06719515
133TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.05575793
134PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.05556879
135EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.05461619
136SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05260127
137P53_22387025_ChIP-Seq_ESCs_Mouse1.04943832
138ESET_19884257_ChIP-Seq_ESCs_Mouse1.04456439
139CMYC_18555785_Chip-Seq_ESCs_Mouse1.04423857
140SMAD4_21799915_ChIP-Seq_A2780_Human1.04354411
141SA1_27219007_Chip-Seq_Bcells_Human1.03931970
142SOX2_19829295_ChIP-Seq_ESCs_Human1.03795230
143NANOG_19829295_ChIP-Seq_ESCs_Human1.03795230
144RUNX2_22187159_ChIP-Seq_PCA_Human1.03752883
145TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.03652699
146MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.02408546
147NFIB_24661679_ChIP-Seq_LUNG_Mouse1.02172834
148GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01825066
149SUZ12_27294783_Chip-Seq_ESCs_Mouse1.00986414
150EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.00860249
151ERG_20517297_ChIP-Seq_VCAP_Human0.98872474
152RXRA_24833708_ChIP-Seq_LIVER_Mouse0.98676194
153RARA_24833708_ChIP-Seq_LIVER_Mouse0.98659811
154RNF2_27304074_Chip-Seq_NSC_Mouse0.98599224
155P300_18555785_Chip-Seq_ESCs_Mouse0.98574675
156RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.98079065
157FOXA1_21572438_ChIP-Seq_LNCaP_Human0.97970228
158GATA1_19941827_ChIP-Seq_MEL86_Mouse0.97959970
159KLF4_18555785_Chip-Seq_ESCs_Mouse0.97884540
160LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.97233276
161OCT4_21477851_ChIP-Seq_ESCs_Mouse0.96766822
162KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.96055620
163KLF5_25053715_ChIP-Seq_YYC3_Human0.95786584
164MYC_27129775_Chip-Seq_CORNEA_Mouse0.95525915
165KLF4_19829295_ChIP-Seq_ESCs_Human0.95327640
166PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.95208691
167EZH2_27294783_Chip-Seq_NPCs_Mouse0.94807732
168ESRRB_18555785_Chip-Seq_ESCs_Mouse0.94206232
169SOX9_26525672_Chip-Seq_HEART_Mouse0.93974554
170EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.91801594
171YY1_22570637_ChIP-Seq_MALME-3M_Human0.91743835
172FLI1_21867929_ChIP-Seq_CD8_Mouse0.91662799
173GF1B_26923725_Chip-Seq_HPCs_Mouse0.91634200
174SUZ12_18555785_Chip-Seq_ESCs_Mouse0.90659859
175SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.90636847
176JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.90319264
177NFYB_21822215_ChIP-Seq_K562_Human0.89568107

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.11787317
2MP0001929_abnormal_gametogenesis5.56710856
3MP0008877_abnormal_DNA_methylation4.06084933
4MP0002210_abnormal_sex_determination3.39031144
5MP0002161_abnormal_fertility/fecundity3.32595322
6MP0001348_abnormal_lacrimal_gland3.16980003
7MP0001145_abnormal_male_reproductive2.89013226
8MP0005670_abnormal_white_adipose2.86386864
9MP0000653_abnormal_sex_gland2.51149645
10MP0002653_abnormal_ependyma_morphology2.46052538
11MP0005451_abnormal_body_composition2.28410892
12MP0005379_endocrine/exocrine_gland_phen2.27778233
13MP0005310_abnormal_salivary_gland2.20001840
14MP0005410_abnormal_fertilization16.5420645
15MP0003718_maternal_effect1.92285724
16MP0001485_abnormal_pinna_reflex1.82469720
17MP0004510_myositis1.68334314
18MP0001486_abnormal_startle_reflex1.66376993
19MP0004233_abnormal_muscle_weight1.56488398
20MP0000678_abnormal_parathyroid_gland1.54179084
21MP0002160_abnormal_reproductive_system1.51131505
22MP0005623_abnormal_meninges_morphology1.47128492
23MP0003646_muscle_fatigue1.35877477
24MP0003172_abnormal_lysosome_physiology1.25305730
25MP0005167_abnormal_blood-brain_barrier1.23509476
26MP0002282_abnormal_trachea_morphology1.21811422
27MP0002138_abnormal_hepatobiliary_system1.20599600
28MP0001765_abnormal_ion_homeostasis1.15367577
29MP0001963_abnormal_hearing_physiology1.13807307
30MP0001984_abnormal_olfaction1.09755948
31MP0004859_abnormal_synaptic_plasticity0.98095009
32MP0008058_abnormal_DNA_repair0.97087504
33MP0009046_muscle_twitch0.96520805
34MP0002234_abnormal_pharynx_morphology0.95713493
35MP0002254_reproductive_system_inflammat0.93888172
36MP0005647_abnormal_sex_gland0.90809897
37MP0009764_decreased_sensitivity_to0.89715951
38MP0002735_abnormal_chemical_nociception0.86897540
39MP0009053_abnormal_anal_canal0.86331678
40MP0002127_abnormal_cardiovascular_syste0.83507992
41MP0000026_abnormal_inner_ear0.82994422
42MP0005395_other_phenotype0.80274372
43MP0002733_abnormal_thermal_nociception0.76856828
44MP0005389_reproductive_system_phenotype0.76140371
45MP0008995_early_reproductive_senescence0.75364869
46MP0010329_abnormal_lipoprotein_level0.73243987
47MP0000230_abnormal_systemic_arterial0.71997318
48MP0002067_abnormal_sensory_capabilities0.69327622
49MP0003115_abnormal_respiratory_system0.67333835
50MP0003011_delayed_dark_adaptation0.66406225
51MP0005636_abnormal_mineral_homeostasis0.64327567
52MP0001501_abnormal_sleep_pattern0.64133240
53MP0006082_CNS_inflammation0.63350125
54MP0002822_catalepsy0.60990473
55MP0002557_abnormal_social/conspecific_i0.60862296
56MP0004085_abnormal_heartbeat0.60181511
57MP0005248_abnormal_Harderian_gland0.59055814
58MP0001905_abnormal_dopamine_level0.58466128
59MP0005083_abnormal_biliary_tract0.57710308
60MP0003878_abnormal_ear_physiology0.57374656
61MP0005377_hearing/vestibular/ear_phenot0.57374656
62MP0000955_abnormal_spinal_cord0.56702170
63MP0005332_abnormal_amino_acid0.56669936
64MP0009697_abnormal_copulation0.56018968
65MP0001835_abnormal_antigen_presentation0.55003243
66MP0002572_abnormal_emotion/affect_behav0.54423467
67MP0002102_abnormal_ear_morphology0.53865569
68MP0005666_abnormal_adipose_tissue0.53841864
69MP0001324_abnormal_eye_pigmentation0.53463037
70MP0004484_altered_response_of0.53371767
71MP0002249_abnormal_larynx_morphology0.53068803
72MP0010094_abnormal_chromosome_stability0.52845124
73MP0001970_abnormal_pain_threshold0.52739988
74MP0005595_abnormal_vascular_smooth0.51712824
75MP0005166_decreased_susceptibility_to0.51154204
76MP0005084_abnormal_gallbladder_morpholo0.51147434
77MP0005645_abnormal_hypothalamus_physiol0.50902907
78MP0003329_amyloid_beta_deposits0.50644317
79MP0001666_abnormal_nutrient_absorption0.50583478
80MP0004036_abnormal_muscle_relaxation0.50290991
81MP0009785_altered_susceptibility_to0.49717933
82MP0002928_abnormal_bile_duct0.48936617
83MP0003303_peritoneal_inflammation0.48663793
84MP0002269_muscular_atrophy0.48150735
85MP0000358_abnormal_cell_content/0.47856890
86MP0003699_abnormal_female_reproductive0.47465711
87MP0001873_stomach_inflammation0.46447944
88MP0001764_abnormal_homeostasis0.45948821
89MP0009745_abnormal_behavioral_response0.44569053
90MP0005551_abnormal_eye_electrophysiolog0.44170896
91MP0001440_abnormal_grooming_behavior0.44121787
92MP0000249_abnormal_blood_vessel0.43254708
93MP0001293_anophthalmia0.42474967
94MP0002736_abnormal_nociception_after0.42067741
95MP0001533_abnormal_skeleton_physiology0.41096212
96MP0002136_abnormal_kidney_physiology0.40827391
97MP0005253_abnormal_eye_physiology0.40379111
98MP0000569_abnormal_digit_pigmentation0.39473820
99MP0006036_abnormal_mitochondrial_physio0.38236288
100MP0003950_abnormal_plasma_membrane0.36912080
101MP0009115_abnormal_fat_cell0.35840176
102MP0005397_hematopoietic_system_phenotyp0.34462379
103MP0001545_abnormal_hematopoietic_system0.34462379
104MP0000534_abnormal_ureter_morphology0.33991856
105MP0004133_heterotaxia0.33673106
106MP0003633_abnormal_nervous_system0.33287170
107MP0004019_abnormal_vitamin_homeostasis0.32841890
108MP0002971_abnormal_brown_adipose0.31893925
109MP0009278_abnormal_bone_marrow0.30042436
110MP0001119_abnormal_female_reproductive0.29925009
111MP0002139_abnormal_hepatobiliary_system0.29653511
112MP0005391_vision/eye_phenotype0.28756235
113MP0003111_abnormal_nucleus_morphology0.28403963
114MP0004811_abnormal_neuron_physiology0.28013699
115MP0003942_abnormal_urinary_system0.26624043
116MP0008057_abnormal_DNA_replication0.26470530
117MP0000604_amyloidosis0.25654596
118MP0001968_abnormal_touch/_nociception0.25620689
119MP0003786_premature_aging0.25439629
120MP0010307_abnormal_tumor_latency0.24707651
121MP0003861_abnormal_nervous_system0.24627061
122MP0003631_nervous_system_phenotype0.24457234
123MP0001730_embryonic_growth_arrest0.24098420
124MP0006035_abnormal_mitochondrial_morpho0.22998754
125MP0002152_abnormal_brain_morphology0.22452955
126MP0002169_no_abnormal_phenotype0.21247811
127MP0002873_normal_phenotype0.20998019
128MP0003948_abnormal_gas_homeostasis0.20252142
129MP0003879_abnormal_hair_cell0.19279280
130MP0004742_abnormal_vestibular_system0.18852618
131MP0005423_abnormal_somatic_nervous0.16796149
132MP0005365_abnormal_bile_salt0.16243753
133MP0005319_abnormal_enzyme/_coenzyme0.15871896
134MP0008875_abnormal_xenobiotic_pharmacok0.15720803
135MP0001849_ear_inflammation0.15507642
136MP0000313_abnormal_cell_death0.15475035
137MP0002229_neurodegeneration0.15240484
138MP0004145_abnormal_muscle_electrophysio0.15063372
139MP0002132_abnormal_respiratory_system0.14647318
140MP0002295_abnormal_pulmonary_circulatio0.14447459
141MP0002084_abnormal_developmental_patter0.14231990
142MP0008007_abnormal_cellular_replicative0.14130047
143MP0002693_abnormal_pancreas_physiology0.13880757
144MP0008961_abnormal_basal_metabolism0.13756507
145MP0000001_mammalian_phenotype0.13299931
146MP0005195_abnormal_posterior_eye0.13184496
147MP0004043_abnormal_pH_regulation0.13116944
148MP0005535_abnormal_body_temperature0.13045336
149MP0008569_lethality_at_weaning0.12849394
150MP0002909_abnormal_adrenal_gland0.12789937
151MP0005375_adipose_tissue_phenotype0.12287209
152MP0002092_abnormal_eye_morphology0.11900258
153MP0002118_abnormal_lipid_homeostasis0.11480164
154MP0003959_abnormal_lean_body0.11355182

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.46958432
2Abnormal respiratory motile cilium morphology (HP:0005938)9.38840953
3Abnormal respiratory epithelium morphology (HP:0012253)9.38840953
4Severe visual impairment (HP:0001141)8.05007261
5Abnormal ciliary motility (HP:0012262)7.62465955
6Rhinitis (HP:0012384)7.52705350
7Chronic bronchitis (HP:0004469)7.46976065
8Infertility (HP:0000789)6.75299560
9Nasal polyposis (HP:0100582)6.40544705
10Chronic hepatic failure (HP:0100626)6.11991799
11Abnormality of the nasal mucosa (HP:0000433)5.26552765
12Cone-rod dystrophy (HP:0000548)4.68689624
13Male infertility (HP:0003251)4.61162234
14Bronchitis (HP:0012387)4.57767253
15Resting tremor (HP:0002322)4.57003005
16Hyperkalemia (HP:0002153)4.53152718
17Attenuation of retinal blood vessels (HP:0007843)4.51515198
18Bony spicule pigmentary retinopathy (HP:0007737)4.50844151
19Abnormality of macular pigmentation (HP:0008002)4.49880479
20Bronchiectasis (HP:0002110)4.41957467
21Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.21268631
22Nephronophthisis (HP:0000090)3.97746201
23Hypoalphalipoproteinemia (HP:0003233)3.89261056
24Abnormal spermatogenesis (HP:0008669)3.59488111
25Hypoplasia of the thymus (HP:0000778)3.58983532
26Progressive sensorineural hearing impairment (HP:0000408)3.56120867
27Amelogenesis imperfecta (HP:0000705)3.50278574
28Recurrent sinusitis (HP:0011108)3.49107669
29Menstrual irregularities (HP:0000858)3.44479219
30Abnormality of dental color (HP:0011073)3.37658764
31Aplasia/Hypoplasia of the earlobes (HP:0009906)3.35754778
32Recurrent otitis media (HP:0000403)3.27489294
33Potter facies (HP:0002009)3.26926079
34Facial shape deformation (HP:0011334)3.26926079
35Abnormal rod and cone electroretinograms (HP:0008323)3.22889766
36Portal hypertension (HP:0001409)3.19511165
37Enlarged epiphyses (HP:0010580)3.18348178
38Renovascular hypertension (HP:0100817)3.14724089
39Insulin-resistant diabetes mellitus (HP:0000831)3.10927803
40Hypoplastic ischia (HP:0003175)3.00853683
41Abnormality of the renal medulla (HP:0100957)2.99025583
42Progressive cerebellar ataxia (HP:0002073)2.96491316
43Postural instability (HP:0002172)2.96479229
44Abnormality of the hepatic vasculature (HP:0006707)2.91655757
45Medial flaring of the eyebrow (HP:0010747)2.77765440
46Tubulointerstitial nephritis (HP:0001970)2.69949682
47Abnormality of the ischium (HP:0003174)2.66450078
48Recurrent bronchitis (HP:0002837)2.64961378
49Molar tooth sign on MRI (HP:0002419)2.56892392
50Abnormality of midbrain morphology (HP:0002418)2.56892392
51Abnormality of the costochondral junction (HP:0000919)2.55420072
52Generalized aminoaciduria (HP:0002909)2.52791882
53Progressive hearing impairment (HP:0001730)2.52499210
54Impulsivity (HP:0100710)2.50907920
55Tubular atrophy (HP:0000092)2.45106760
56Abnormality of potassium homeostasis (HP:0011042)2.38307172
57Focal segmental glomerulosclerosis (HP:0000097)2.35171517
58Azoospermia (HP:0000027)2.34027680
59Increased purine levels (HP:0004368)2.31975497
60Hyperuricemia (HP:0002149)2.31975497
61Tubulointerstitial abnormality (HP:0001969)2.28131652
62Subcapsular cataract (HP:0000523)2.25842757
63Ventricular tachycardia (HP:0004756)2.20407434
64Intellectual disability, moderate (HP:0002342)2.17753272
65Abnormal gallbladder physiology (HP:0012438)2.15356651
66Cholecystitis (HP:0001082)2.15356651
67Gonadotropin excess (HP:0000837)2.15222950
68Recurrent pneumonia (HP:0006532)2.14121855
69Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.12282269
70Polyuria (HP:0000103)2.03165536
71Dyschromatopsia (HP:0007641)2.03016104
72Bradycardia (HP:0001662)2.02954962
73Congenital sensorineural hearing impairment (HP:0008527)2.00106791
74Absent/shortened dynein arms (HP:0200106)13.5798835
75Dynein arm defect of respiratory motile cilia (HP:0012255)13.5798835
76Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.2436067
77Glomerulosclerosis (HP:0000096)1.98101465
78Flat capital femoral epiphysis (HP:0003370)1.97794616
79Unilateral renal agenesis (HP:0000122)1.97303121
80Osteomalacia (HP:0002749)1.97180471
81Pendular nystagmus (HP:0012043)1.95963064
82Nephritis (HP:0000123)1.95774730
83Hypophosphatemic rickets (HP:0004912)1.93710946
84Recurrent corneal erosions (HP:0000495)1.90016544
85Widely patent fontanelles and sutures (HP:0004492)1.88722230
86Abnormality of purine metabolism (HP:0004352)1.87864180
87Hypolipoproteinemia (HP:0010981)1.87205355
88Decreased central vision (HP:0007663)1.85251281
89Flattened epiphyses (HP:0003071)1.84735842
90Gingivitis (HP:0000230)1.82455716
91Tubulointerstitial fibrosis (HP:0005576)1.81622314
92Abnormal albumin level (HP:0012116)1.81260004
93Hypoalbuminemia (HP:0003073)1.81260004
94Horizontal nystagmus (HP:0000666)1.78573187
95Photophobia (HP:0000613)1.78318488
96Spastic tetraparesis (HP:0001285)1.78163945
97Postaxial foot polydactyly (HP:0001830)1.76645761
98Epiphyseal dysplasia (HP:0002656)1.75595157
99Gait imbalance (HP:0002141)1.75586703
100Congenital primary aphakia (HP:0007707)1.75380141
101Choroideremia (HP:0001139)1.75185710
102Hyponatremia (HP:0002902)1.74920917
103Abnormality of the epiphysis of the femoral head (HP:0010574)1.73781599
104Stage 5 chronic kidney disease (HP:0003774)1.69141446
105Hypergonadotropic hypogonadism (HP:0000815)1.69135865
106Abnormality of chloride homeostasis (HP:0011422)1.68902197
107Insulin resistance (HP:0000855)1.68846569
108Heterotopia (HP:0002282)1.68415786
109Myokymia (HP:0002411)1.68029311
110Aplasia/Hypoplasia of the lens (HP:0008063)1.66203291
111Congenital hepatic fibrosis (HP:0002612)1.64648325
112Abnormal drinking behavior (HP:0030082)1.62138142
113Polydipsia (HP:0001959)1.62138142
114Hypoplasia of the capital femoral epiphysis (HP:0003090)1.61211768
115Abnormality of renal excretion (HP:0011036)1.58271962
116Chronic sinusitis (HP:0011109)1.58201279
117Abnormality of the renal cortex (HP:0011035)1.55285978
118Asymmetric septal hypertrophy (HP:0001670)1.51285161
119Postaxial hand polydactyly (HP:0001162)1.49576526
120Abnormal biliary tract physiology (HP:0012439)1.49571146
121Bile duct proliferation (HP:0001408)1.49571146
122Nephrogenic diabetes insipidus (HP:0009806)1.49349293
123Abnormality of permanent molar morphology (HP:0011071)1.48451350
124Abnormality of the dental root (HP:0006486)1.48451350
125Taurodontia (HP:0000679)1.48451350
126Short ribs (HP:0000773)1.48068644
127Hemorrhage of the eye (HP:0011885)1.47897483
128Oculomotor apraxia (HP:0000657)1.45715821
129Congenital malformation of the right heart (HP:0011723)1.43431803
130Double outlet right ventricle (HP:0001719)1.43431803
131Bell-shaped thorax (HP:0001591)1.41425128
132Renal dysplasia (HP:0000110)1.41388886
133Facial cleft (HP:0002006)1.39609679
134Fibular hypoplasia (HP:0003038)1.39332618
135Abnormality of molar (HP:0011077)1.37803683
136Abnormality of molar morphology (HP:0011070)1.37803683
137Bundle branch block (HP:0011710)1.37692093
138Abnormality of the dental pulp (HP:0006479)1.37380965
139Vaginal atresia (HP:0000148)1.35831752
140Genital tract atresia (HP:0001827)1.34970060
141Abnormality of saccadic eye movements (HP:0000570)1.34390503
142Cystic liver disease (HP:0006706)1.34219550
143Neurofibrillary tangles (HP:0002185)1.34071046
144Easy fatigability (HP:0003388)1.32661510
145Decreased electroretinogram (ERG) amplitude (HP:0000654)1.32360006
146Pancreatic fibrosis (HP:0100732)1.31926804
147Poor coordination (HP:0002370)1.30537779
148Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.29661555
149Abnormality of dentin (HP:0010299)1.29099347
150Cerebellar dysplasia (HP:0007033)1.28750581
151Absent epiphyses (HP:0010577)1.26184826
152Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.26184826
153Constricted visual fields (HP:0001133)1.26017378
154Fatigable weakness (HP:0003473)1.25723764
155Abnormality of the neuromuscular junction (HP:0003398)1.25723764
156Abnormality of ocular smooth pursuit (HP:0000617)1.24409364
157Abnormal urine output (HP:0012590)1.24192076
158Abnormality of the lower motor neuron (HP:0002366)1.24189352
159Sensory axonal neuropathy (HP:0003390)1.23039248
160Microglossia (HP:0000171)1.21311302
161Deformed sella turcica (HP:0002681)1.19942452
162Aplasia/Hypoplasia of the tongue (HP:0010295)1.19607466
163Tongue fasciculations (HP:0001308)1.15706922
164Hemiparesis (HP:0001269)1.15566798
165Hypercholesterolemia (HP:0003124)1.14425197
166Exercise-induced myalgia (HP:0003738)1.13605530
167Truncal obesity (HP:0001956)1.13357133

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK38.59528463
2PDK48.59528463
3TESK15.89149711
4PDK25.57352634
5MAP4K25.55937960
6PRKD34.80514962
7INSRR4.40214678
8ICK4.09111084
9BRD43.96016834
10DDR23.73359099
11PLK23.33887643
12PIK3CG2.40331624
13PTK2B2.12111730
14WNK42.02626743
15STK391.95449805
16STK381.72630527
17PNCK1.66132740
18DYRK1B1.56391051
19NEK21.46655144
20MST1R1.29613986
21PDK11.19456021
22TIE10.93418790
23CAMK1D0.93253306
24IRAK10.91921870
25DYRK30.85402518
26MAP3K110.85081289
27TYRO30.82535907
28LMTK20.73245589
29KSR20.72584259
30MAPK150.71774578
31BLK0.71297858
32WNK10.70952195
33PDPK10.70838366
34TESK20.69252980
35MAP3K90.68850748
36CDK70.68039354
37PASK0.67732317
38CCNB10.65272042
39NTRK30.62240365
40RIPK40.62038614
41CHEK20.61309057
42AKT30.61271760
43RPS6KA20.60983125
44PRKAA20.60821631
45STK30.59255110
46SIK20.59105622
47MAP2K60.58815568
48JAK30.57919990
49EEF2K0.57069039
50TTK0.54380505
51MAP3K20.53374128
52GRK70.53092901
53SGK4940.52450828
54SGK2230.52450828
55STK38L0.51721867
56CAMK10.50983716
57PINK10.50079522
58IRAK20.48725901
59PLK40.46038964
60CDK30.44939868
61CAMK1G0.43135074
62ZAK0.41200041
63SGK20.38637404
64MUSK0.38596220
65PAK10.38258237
66MAP3K10.37979811
67CHEK10.37842353
68MAPK10.37242088
69MAP2K20.36182065
70FRK0.35781522
71ROCK10.35382518
72MAP3K80.34555339
73RPS6KC10.34160202
74RPS6KL10.34160202
75NTRK20.33357692
76LATS20.31943837
77PRKCG0.31771539
78BRSK20.31518269
79RPS6KA60.31463156
80TNIK0.30561842
81WEE10.28598926
82ACVR1B0.28208924
83SGK10.27617259
84ADRBK20.27490135
85MAP3K100.27005700
86CAMK40.26362270
87MAPKAPK50.25125454
88ATM0.25064898
89PAK20.24928747
90UHMK10.24715248
91ATR0.24032745
92SGK30.22346494
93MARK20.22343241
94MTOR0.22245418
95CDK120.20527696
96CAMKK10.19728141
97NEK60.19671355
98IKBKB0.17928317
99PRKAA10.17521400
100PAK40.16425204
101ABL20.15826327
102MAPK140.14954889
103PRKCZ0.14943071
104CDK150.14387224
105BRSK10.14364767
106PLK10.14245919
107KIT0.14177113
108MAP3K30.13806751
109PRKG20.13414776
110MAPK100.13108517
111RPS6KB10.12879325
112CDK180.12665185
113SYK0.12521887
114MARK30.12096329
115MAPK110.11868279
116CHUK0.11174327
117PKN10.10887630
118PRKCQ0.10498872
119CDK11A0.10428205
120CDC70.09370013
121AKT10.08744012
122PRKACA0.08426561
123CDK140.07397515
124CSNK2A10.06937271
125RPS6KA10.06931601
126MOS0.06482272
127YES10.06236247
128RIPK10.06188139
129BRAF0.05921572
130PRKG10.05680981
131GSK3B0.05202633
132PRKACG0.04469616
133CSNK1D0.03588148
134STK110.03091171
135CSNK2A20.02786059
136CAMK2A0.02649943
137STK100.02569520
138ZAP700.02528093
139CSF1R0.02413238
140CDK20.02199456
141CDK60.02126037
142PDGFRB0.02098978
143MAPK80.01850850
144CDK10.01721547
145PRKCD0.01346451
146EGFR0.01314639
147AURKA0.00441719
148PRKCB0.00351316
149PRKCA0.00319772
150CDK4-0.0312185
151RPS6KA3-0.0309612
152PRKACB-0.0233235
153MAP3K5-0.0164239
154PIM1-0.0160964
155MAP3K4-0.0134987
156WNK3-0.0090580
157MARK1-0.0080946

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000725.94293502
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.44359528
3Fatty acid biosynthesis_Homo sapiens_hsa000614.43628402
4Vitamin B6 metabolism_Homo sapiens_hsa007503.87254665
5Olfactory transduction_Homo sapiens_hsa047403.79300345
6Pyruvate metabolism_Homo sapiens_hsa006203.52729536
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.94156142
8Linoleic acid metabolism_Homo sapiens_hsa005912.84979635
9Propanoate metabolism_Homo sapiens_hsa006402.76031779
10Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.66695679
11Glucagon signaling pathway_Homo sapiens_hsa049222.55845250
12Basal transcription factors_Homo sapiens_hsa030222.42900980
13Carbohydrate digestion and absorption_Homo sapiens_hsa049732.25798657
14Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.13578923
15Selenocompound metabolism_Homo sapiens_hsa004502.08883321
16Butanoate metabolism_Homo sapiens_hsa006502.04089838
17Glycerolipid metabolism_Homo sapiens_hsa005612.02205977
18Type I diabetes mellitus_Homo sapiens_hsa049401.99137479
19Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.96362682
20Glycosaminoglycan degradation_Homo sapiens_hsa005311.96152526
21Pentose phosphate pathway_Homo sapiens_hsa000301.94995038
22PPAR signaling pathway_Homo sapiens_hsa033201.90300469
23Allograft rejection_Homo sapiens_hsa053301.82472370
24Oocyte meiosis_Homo sapiens_hsa041141.74903361
25Autoimmune thyroid disease_Homo sapiens_hsa053201.71170840
26Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.70929082
27Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.65749327
28Graft-versus-host disease_Homo sapiens_hsa053321.62719714
29Glycerophospholipid metabolism_Homo sapiens_hsa005641.61988266
30Fructose and mannose metabolism_Homo sapiens_hsa000511.55381683
31Type II diabetes mellitus_Homo sapiens_hsa049301.55260352
32Mineral absorption_Homo sapiens_hsa049781.53361741
33Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.47777866
34Carbon metabolism_Homo sapiens_hsa012001.44058383
35Amphetamine addiction_Homo sapiens_hsa050311.43737528
36Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.40351014
37Fat digestion and absorption_Homo sapiens_hsa049751.39746742
38Phenylalanine metabolism_Homo sapiens_hsa003601.34213423
39Fatty acid degradation_Homo sapiens_hsa000711.31949441
40Ether lipid metabolism_Homo sapiens_hsa005651.31466413
41Fanconi anemia pathway_Homo sapiens_hsa034601.31280521
42Fatty acid metabolism_Homo sapiens_hsa012121.30399381
43Cardiac muscle contraction_Homo sapiens_hsa042601.29202131
44Dorso-ventral axis formation_Homo sapiens_hsa043201.28681795
45Primary bile acid biosynthesis_Homo sapiens_hsa001201.26904865
46Cysteine and methionine metabolism_Homo sapiens_hsa002701.16771383
47Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.14425435
48Viral myocarditis_Homo sapiens_hsa054161.12487491
49Purine metabolism_Homo sapiens_hsa002301.07219364
50Influenza A_Homo sapiens_hsa051641.06016871
51Renin secretion_Homo sapiens_hsa049241.05760912
52Phototransduction_Homo sapiens_hsa047441.04256277
53Huntingtons disease_Homo sapiens_hsa050161.03981959
54Glutathione metabolism_Homo sapiens_hsa004801.03169909
55Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.01690871
56Collecting duct acid secretion_Homo sapiens_hsa049661.00431876
57Antigen processing and presentation_Homo sapiens_hsa046120.99213232
58Biosynthesis of amino acids_Homo sapiens_hsa012300.96430108
59Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.94910701
60Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.93094130
61Morphine addiction_Homo sapiens_hsa050320.92095632
62mRNA surveillance pathway_Homo sapiens_hsa030150.89780452
63Glutamatergic synapse_Homo sapiens_hsa047240.82723100
64RNA transport_Homo sapiens_hsa030130.82633574
65Chemical carcinogenesis_Homo sapiens_hsa052040.80859657
66Hedgehog signaling pathway_Homo sapiens_hsa043400.80569589
67Insulin secretion_Homo sapiens_hsa049110.79150728
68Renin-angiotensin system_Homo sapiens_hsa046140.75056513
69Staphylococcus aureus infection_Homo sapiens_hsa051500.73841084
70Bile secretion_Homo sapiens_hsa049760.73756085
71Arachidonic acid metabolism_Homo sapiens_hsa005900.73361601
72Adipocytokine signaling pathway_Homo sapiens_hsa049200.73196401
73Thyroid hormone synthesis_Homo sapiens_hsa049180.70486840
74Long-term potentiation_Homo sapiens_hsa047200.66718614
75Arginine biosynthesis_Homo sapiens_hsa002200.66626238
76Systemic lupus erythematosus_Homo sapiens_hsa053220.65745638
77Estrogen signaling pathway_Homo sapiens_hsa049150.65565031
78Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.64394760
79Serotonergic synapse_Homo sapiens_hsa047260.63234324
80cGMP-PKG signaling pathway_Homo sapiens_hsa040220.63213243
81Acute myeloid leukemia_Homo sapiens_hsa052210.62119056
82Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.58991853
83Central carbon metabolism in cancer_Homo sapiens_hsa052300.55673250
84Jak-STAT signaling pathway_Homo sapiens_hsa046300.55203984
85Synaptic vesicle cycle_Homo sapiens_hsa047210.54912387
86Inositol phosphate metabolism_Homo sapiens_hsa005620.53864788
87Intestinal immune network for IgA production_Homo sapiens_hsa046720.53834839
88Calcium signaling pathway_Homo sapiens_hsa040200.53069857
89ABC transporters_Homo sapiens_hsa020100.52683815
90Protein digestion and absorption_Homo sapiens_hsa049740.52645511
91Pancreatic secretion_Homo sapiens_hsa049720.52586657
92Nicotine addiction_Homo sapiens_hsa050330.52581331
93Arginine and proline metabolism_Homo sapiens_hsa003300.52578248
94Legionellosis_Homo sapiens_hsa051340.52570380
95Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.50667761
96Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.48886387
97Nitrogen metabolism_Homo sapiens_hsa009100.48579763
98Phosphatidylinositol signaling system_Homo sapiens_hsa040700.48361798
99Salivary secretion_Homo sapiens_hsa049700.47536681
100Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.46967636
101Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.46765252
102Leishmaniasis_Homo sapiens_hsa051400.46170283
103Asthma_Homo sapiens_hsa053100.45518901
104Sulfur metabolism_Homo sapiens_hsa009200.43670040
105Tyrosine metabolism_Homo sapiens_hsa003500.43221543
106Thyroid hormone signaling pathway_Homo sapiens_hsa049190.42873397
107Retinol metabolism_Homo sapiens_hsa008300.42823973
108Endocytosis_Homo sapiens_hsa041440.42778014
109Toxoplasmosis_Homo sapiens_hsa051450.42582760
110Tryptophan metabolism_Homo sapiens_hsa003800.42134036
111AMPK signaling pathway_Homo sapiens_hsa041520.41530171
112Metabolic pathways_Homo sapiens_hsa011000.41461882
113Aldosterone synthesis and secretion_Homo sapiens_hsa049250.40722722
114Gastric acid secretion_Homo sapiens_hsa049710.39962994
115MAPK signaling pathway_Homo sapiens_hsa040100.39354737
116Prolactin signaling pathway_Homo sapiens_hsa049170.38866092
117Osteoclast differentiation_Homo sapiens_hsa043800.37740918
118Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.37637675
119Taste transduction_Homo sapiens_hsa047420.36306615
120Vascular smooth muscle contraction_Homo sapiens_hsa042700.35416235
121Herpes simplex infection_Homo sapiens_hsa051680.34154933
122Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.33643694
123Sulfur relay system_Homo sapiens_hsa041220.32827798
124Lysosome_Homo sapiens_hsa041420.31963240
125Cholinergic synapse_Homo sapiens_hsa047250.31837711
126Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.31811888
127Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.31347263
128VEGF signaling pathway_Homo sapiens_hsa043700.30326744
129Tuberculosis_Homo sapiens_hsa051520.30171432
130Oxytocin signaling pathway_Homo sapiens_hsa049210.29978552
131GABAergic synapse_Homo sapiens_hsa047270.29780070
132Transcriptional misregulation in cancer_Homo sapiens_hsa052020.29689907
133Maturity onset diabetes of the young_Homo sapiens_hsa049500.29386427
134N-Glycan biosynthesis_Homo sapiens_hsa005100.28390550
135Pentose and glucuronate interconversions_Homo sapiens_hsa000400.28335411
136cAMP signaling pathway_Homo sapiens_hsa040240.28283350
137Pyrimidine metabolism_Homo sapiens_hsa002400.27600213
138Alcoholism_Homo sapiens_hsa050340.26317522
139Chemokine signaling pathway_Homo sapiens_hsa040620.25876142
140Circadian entrainment_Homo sapiens_hsa047130.25440849
141Cocaine addiction_Homo sapiens_hsa050300.16928047
142Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.14620605
143Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.13178274
144Wnt signaling pathway_Homo sapiens_hsa043100.09872852
145Salmonella infection_Homo sapiens_hsa051320.08695435
146HIF-1 signaling pathway_Homo sapiens_hsa040660.06726732
147Viral carcinogenesis_Homo sapiens_hsa052030.06316462
148B cell receptor signaling pathway_Homo sapiens_hsa046620.06049062
149Basal cell carcinoma_Homo sapiens_hsa052170.03199534

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