LRRC75A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.70418019
2ATP synthesis coupled proton transport (GO:0015986)4.43891302
3energy coupled proton transport, down electrochemical gradient (GO:0015985)4.43891302
4rRNA modification (GO:0000154)4.43843338
5translation (GO:0006412)4.30329581
6chaperone-mediated protein transport (GO:0072321)4.24367751
7pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.15835367
8protein complex biogenesis (GO:0070271)4.03615052
9respiratory chain complex IV assembly (GO:0008535)4.03004655
10establishment of protein localization to mitochondrial membrane (GO:0090151)3.91832115
11mitochondrial respiratory chain complex assembly (GO:0033108)3.89098451
12regulation of mitochondrial translation (GO:0070129)3.88816560
13viral transcription (GO:0019083)3.84938998
14formation of translation preinitiation complex (GO:0001731)3.81366421
15mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.79002143
16mitochondrial respiratory chain complex I assembly (GO:0032981)3.79002143
17NADH dehydrogenase complex assembly (GO:0010257)3.79002143
18cytochrome complex assembly (GO:0017004)3.77876668
19ribonucleoprotein complex biogenesis (GO:0022613)3.76211683
20regulation of posttranscriptional gene silencing (GO:0060147)3.75497525
21regulation of gene silencing by miRNA (GO:0060964)3.75497525
22regulation of gene silencing by RNA (GO:0060966)3.75497525
23translational termination (GO:0006415)3.73880746
24nuclear-transcribed mRNA catabolic process (GO:0000956)3.73299004
25deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.70275872
26DNA unwinding involved in DNA replication (GO:0006268)3.68863711
27cellular component biogenesis (GO:0044085)3.67314137
28nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.64848685
29mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.64263551
30proteasome assembly (GO:0043248)3.63756992
31exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.63289419
32pseudouridine synthesis (GO:0001522)3.61934049
33rRNA methylation (GO:0031167)3.61412336
34protein targeting to membrane (GO:0006612)3.57126523
35regulation of integrin activation (GO:0033623)3.54460716
36oxidative phosphorylation (GO:0006119)3.54210797
37mRNA catabolic process (GO:0006402)3.51877317
38regulation of hippo signaling (GO:0035330)3.51872783
39corticosteroid receptor signaling pathway (GO:0031958)3.47074478
40respiratory electron transport chain (GO:0022904)3.45279977
41glucocorticoid receptor signaling pathway (GO:0042921)3.44911596
42electron transport chain (GO:0022900)3.41121776
43pyrimidine nucleotide catabolic process (GO:0006244)3.39877945
44base-excision repair, AP site formation (GO:0006285)3.35043092
45positive regulation of interleukin-1 beta secretion (GO:0050718)3.34589420
46deoxyribonucleotide catabolic process (GO:0009264)3.33936380
47water-soluble vitamin biosynthetic process (GO:0042364)3.33689012
48dosage compensation (GO:0007549)3.32684920
49heterochromatin organization (GO:0070828)3.31394044
50ribosomal small subunit assembly (GO:0000028)3.30806590
51RNA catabolic process (GO:0006401)3.26475084
52pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.26268012
53deoxyribose phosphate catabolic process (GO:0046386)3.25664778
54chromatin assembly (GO:0031497)3.25603679
55rRNA processing (GO:0006364)3.25180492
56translational elongation (GO:0006414)3.22055450
57protein targeting to mitochondrion (GO:0006626)3.17538058
58DNA replication-dependent nucleosome assembly (GO:0006335)3.16927500
59DNA replication-dependent nucleosome organization (GO:0034723)3.16927500
60rRNA metabolic process (GO:0016072)3.15317973
61peptidyl-histidine modification (GO:0018202)3.14614588
62mitotic chromosome condensation (GO:0007076)3.13552230
63termination of RNA polymerase III transcription (GO:0006386)3.10618739
64transcription elongation from RNA polymerase III promoter (GO:0006385)3.10618739
65positive regulation of interleukin-1 secretion (GO:0050716)3.08736837
66pinocytosis (GO:0006907)3.07155824
67regulation of gene silencing (GO:0060968)3.06832337
68mannosylation (GO:0097502)3.05768753
69regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.05614598
70DNA double-strand break processing (GO:0000729)3.04953032
71DNA deamination (GO:0045006)3.04713476
72positive regulation of chemokine secretion (GO:0090197)3.03607556
73nuclear pore complex assembly (GO:0051292)3.00865576
74regulation of histone H3-K9 methylation (GO:0051570)3.00643373
75tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.99749823
76RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.99749823
77nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.99610478
78positive regulation of interleukin-1 beta production (GO:0032731)2.98209977
79antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.96261225
80ribosomal large subunit biogenesis (GO:0042273)2.96241834
81positive regulation of protein dephosphorylation (GO:0035307)2.94999219
82establishment of protein localization to mitochondrion (GO:0072655)2.93067113
83deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.92895157
84DNA strand elongation involved in DNA replication (GO:0006271)2.91982467
85cellular protein complex disassembly (GO:0043624)2.91323436
86RNA stabilization (GO:0043489)2.91101884
87mRNA stabilization (GO:0048255)2.91101884
88aldehyde catabolic process (GO:0046185)2.88346991
89chromatin assembly or disassembly (GO:0006333)2.85511293
90nuclear pore organization (GO:0006999)2.84066003
91viral life cycle (GO:0019058)2.83366628
92negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.83261019
93peptidyl-lysine dimethylation (GO:0018027)2.82449016
94telomere maintenance via semi-conservative replication (GO:0032201)2.81424653
95SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.80810738
96DNA strand elongation (GO:0022616)2.80583897
97replication fork processing (GO:0031297)2.79856821
98ubiquinone biosynthetic process (GO:0006744)2.79340850
99protein localization to mitochondrion (GO:0070585)2.79212608
100maturation of SSU-rRNA (GO:0030490)2.78098109
101response to UV-C (GO:0010225)2.77107757
102regulation of interleukin-1 beta secretion (GO:0050706)2.76783717
103maturation of 5.8S rRNA (GO:0000460)2.76121617
104protein deneddylation (GO:0000338)2.75191359
105protein complex disassembly (GO:0043241)2.75186965
106GTP biosynthetic process (GO:0006183)2.74865557
107cullin deneddylation (GO:0010388)2.74583229
108positive regulation of SMAD protein import into nucleus (GO:0060391)2.74557665
109regulation of spindle organization (GO:0090224)2.73659291
110aerobic respiration (GO:0009060)2.73626259
111tRNA processing (GO:0008033)2.73343148
112translational initiation (GO:0006413)2.73025475
113regulation of chemokine secretion (GO:0090196)2.72837378
114ribosome biogenesis (GO:0042254)2.72179291
115branched-chain amino acid catabolic process (GO:0009083)2.71708357
116pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.71435369
117L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.71376308
118protein targeting to ER (GO:0045047)2.70136614
119deoxyribose phosphate metabolic process (GO:0019692)2.68604475
120chromatin remodeling at centromere (GO:0031055)2.68562687
121DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.67215945
122inner mitochondrial membrane organization (GO:0007007)2.67049367
1232-deoxyribonucleotide metabolic process (GO:0009394)2.66985262
124cotranslational protein targeting to membrane (GO:0006613)2.66215617
125positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.65756406
126transcription-coupled nucleotide-excision repair (GO:0006283)2.65042220
127protein targeting (GO:0006605)2.64816411
128ncRNA processing (GO:0034470)2.64677616
129regulation of mitotic spindle organization (GO:0060236)2.64582554
130purine nucleoside triphosphate biosynthetic process (GO:0009145)2.64242486
131establishment of protein localization to endoplasmic reticulum (GO:0072599)2.63896252
132preassembly of GPI anchor in ER membrane (GO:0016254)2.63847633
133response to interferon-alpha (GO:0035455)2.63298062
134signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.63087378
135signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.63087378
136translesion synthesis (GO:0019985)2.62940401
137macromolecular complex disassembly (GO:0032984)2.62574726
138negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.61809704
139folic acid-containing compound biosynthetic process (GO:0009396)2.61590207
140cell differentiation involved in embryonic placenta development (GO:0060706)2.59747969
141telomere maintenance via recombination (GO:0000722)2.53315783
142ribosomal small subunit biogenesis (GO:0042274)2.51455836
143regulation of interleukin-1 secretion (GO:0050704)2.51114848
144negative regulation of RNA splicing (GO:0033119)2.49049718
145positive regulation of interleukin-1 production (GO:0032732)2.47290618
146mitotic recombination (GO:0006312)2.47065104
147protein localization to kinetochore (GO:0034501)2.45204786
148regulation of translational fidelity (GO:0006450)2.44823380
149regulation of nuclear cell cycle DNA replication (GO:0033262)2.44250402
150wound healing, spreading of epidermal cells (GO:0035313)2.44073836
151labyrinthine layer blood vessel development (GO:0060716)2.43556420
152nucleotide-excision repair, DNA gap filling (GO:0006297)2.42997488
153positive regulation of gene expression, epigenetic (GO:0045815)2.42049788
154DNA duplex unwinding (GO:0032508)2.40738123
155regulation of protein dephosphorylation (GO:0035304)2.39831801
156DNA geometric change (GO:0032392)2.38018970
157protein localization to endoplasmic reticulum (GO:0070972)2.37959245
158negative regulation of cell aging (GO:0090344)2.37835394
159positive regulation by symbiont of host defense response (GO:0052509)2.37048407
160modulation by symbiont of host defense response (GO:0052031)2.37048407
161modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.37048407
162modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.37048407
163positive regulation by organism of defense response of other organism involved in symbiotic interact2.37048407
164modulation by symbiont of host immune response (GO:0052553)2.37048407
165mitotic nuclear envelope disassembly (GO:0007077)2.35628202
166nodal signaling pathway (GO:0038092)2.34888052
167negative regulation of histone methylation (GO:0031061)2.33669899
168negative regulation of gene silencing (GO:0060969)2.32975352
169regulation of mRNA stability (GO:0043488)2.32946923
170negative regulation of DNA repair (GO:0045738)2.31480635
171regulation of RNA stability (GO:0043487)2.30828115
172chromosome condensation (GO:0030261)2.30282389
173mitotic sister chromatid cohesion (GO:0007064)2.27979499
174regulation of SMAD protein import into nucleus (GO:0060390)2.26996339
175membrane disassembly (GO:0030397)2.26292859
176nuclear envelope disassembly (GO:0051081)2.26292859
177meiotic chromosome segregation (GO:0045132)2.25492236
178DNA replication initiation (GO:0006270)2.25062334
179L-alpha-amino acid transmembrane transport (GO:1902475)2.24335145
180placenta blood vessel development (GO:0060674)2.24094975

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.36583853
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.89271140
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.69406906
4GABP_17652178_ChIP-ChIP_JURKAT_Human4.53520534
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.02761295
6EST1_17652178_ChIP-ChIP_JURKAT_Human4.00771816
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.89635754
8ELF1_17652178_ChIP-ChIP_JURKAT_Human3.81174806
9EGR1_19374776_ChIP-ChIP_THP-1_Human3.80788321
10ETS1_20019798_ChIP-Seq_JURKAT_Human3.57838097
11HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.19526137
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.19160007
13E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.15642698
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.96659466
15E2F4_17652178_ChIP-ChIP_JURKAT_Human2.90361833
16VDR_23849224_ChIP-Seq_CD4+_Human2.87905496
17MYC_18555785_ChIP-Seq_MESCs_Mouse2.87023838
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.81810174
19FOXP3_21729870_ChIP-Seq_TREG_Human2.72584261
20ELK1_19687146_ChIP-ChIP_HELA_Human2.70632961
21SRF_21415370_ChIP-Seq_HL-1_Mouse2.62899092
22FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.55084298
23STAT6_21828071_ChIP-Seq_BEAS2B_Human2.53571312
24NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.50772376
25NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.39010675
26TP63_17297297_ChIP-ChIP_HaCaT_Human2.34995629
27EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.33835284
28MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.28334276
29MYC_22102868_ChIP-Seq_BL_Human2.28101101
30SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.19324495
31THAP11_20581084_ChIP-Seq_MESCs_Mouse2.14359835
32GABP_19822575_ChIP-Seq_HepG2_Human2.10993378
33VDR_21846776_ChIP-Seq_THP-1_Human2.10672342
34MYC_18940864_ChIP-ChIP_HL60_Human2.10175880
35MYC_19079543_ChIP-ChIP_MESCs_Mouse2.08822547
36FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.06956151
37TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.99379905
38TCF7_22412390_ChIP-Seq_EML_Mouse1.98970694
39PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.90856050
40E2F1_21310950_ChIP-Seq_MCF-7_Human1.89129913
41PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.88110742
42HOXB4_20404135_ChIP-ChIP_EML_Mouse1.80910376
43ZNF274_21170338_ChIP-Seq_K562_Hela1.74056555
44TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.71542465
45MYC_19030024_ChIP-ChIP_MESCs_Mouse1.67394783
46ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.67253551
47KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.66277199
48ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.64720941
49BRD4_27068464_Chip-Seq_AML-cells_Mouse1.63861803
50XRN2_22483619_ChIP-Seq_HELA_Human1.63297767
51CIITA_25753668_ChIP-Seq_RAJI_Human1.60979654
52PADI4_21655091_ChIP-ChIP_MCF-7_Human1.58815733
53IGF1R_20145208_ChIP-Seq_DFB_Human1.58621207
54YY1_21170310_ChIP-Seq_MESCs_Mouse1.58354480
55YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.57698111
56TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.54564916
57ELK3_25401928_ChIP-Seq_HUVEC_Human1.54544007
58POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.53480282
59KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.52261582
60EWS_26573619_Chip-Seq_HEK293_Human1.48356202
61KDM5A_27292631_Chip-Seq_BREAST_Human1.47802657
62CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.47487719
63VDR_24763502_ChIP-Seq_THP-1_Human1.47362198
64KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.45778153
65ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.43343568
66ATF3_27146783_Chip-Seq_COLON_Human1.42270841
67KDM2B_26808549_Chip-Seq_SUP-B15_Human1.42138164
68MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.41866559
69MYC_18358816_ChIP-ChIP_MESCs_Mouse1.40844545
70BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.40817415
71NELFA_20434984_ChIP-Seq_ESCs_Mouse1.40444172
72FUS_26573619_Chip-Seq_HEK293_Human1.38375536
73AR_21909140_ChIP-Seq_LNCAP_Human1.38139206
74NANOG_18555785_ChIP-Seq_MESCs_Mouse1.37586927
75KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.33564310
76UTX_26944678_Chip-Seq_JUKART_Human1.33192954
77SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.32433853
78HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.31950201
79KDM2B_26808549_Chip-Seq_DND41_Human1.31745165
80DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.31693155
81IRF8_22096565_ChIP-ChIP_GC-B_Human1.31202165
82MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.30829995
83CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.30592425
84CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.29741226
85RBPJ_22232070_ChIP-Seq_NCS_Mouse1.29503949
86NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.28498807
87HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.27407937
88POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.27406844
89ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.26447389
90STAT3_1855785_ChIP-Seq_MESCs_Mouse1.26067776
91VDR_22108803_ChIP-Seq_LS180_Human1.25228457
92TFEB_21752829_ChIP-Seq_HELA_Human1.24302552
93MAF_26560356_Chip-Seq_TH1_Human1.22614822
94IRF1_19129219_ChIP-ChIP_H3396_Human1.21909538
95SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.21615343
96GATA6_25053715_ChIP-Seq_YYC3_Human1.21507095
97KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.21086729
98EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.20246787
99IRF8_21731497_ChIP-ChIP_J774_Mouse1.19341433
100CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.17763079
101MYB_21317192_ChIP-Seq_ERMYB_Mouse1.17088831
102RACK7_27058665_Chip-Seq_MCF-7_Human1.16401045
103CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.15564862
104ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.15269582
105KLF4_18555785_ChIP-Seq_MESCs_Mouse1.14888935
106RARG_19884340_ChIP-ChIP_MEFs_Mouse1.14586964
107CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.14405040
108TTF2_22483619_ChIP-Seq_HELA_Human1.13764827
109RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.13748894
110ZFX_18555785_ChIP-Seq_MESCs_Mouse1.13105512
111SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.11301952
112KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.09806276
113KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.08690872
114SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.06381024
115RUNX1_22412390_ChIP-Seq_EML_Mouse1.06080238
116SPI1_23547873_ChIP-Seq_NB4_Human1.05257227
117MYCN_18555785_ChIP-Seq_MESCs_Mouse1.04858859
118E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.04744842
119ELK1_22589737_ChIP-Seq_MCF10A_Human1.04170014
120HIF1A_21447827_ChIP-Seq_MCF-7_Human1.03573884
121CDX2_20551321_ChIP-Seq_CACO-2_Human1.03294606
122NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.02769791
123TP53_22573176_ChIP-Seq_HFKS_Human1.02723945
124SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.02536415
125NCOR1_26117541_ChIP-Seq_K562_Human1.02510517
126TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.02506165
127RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.02387361
128CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.01638821
129SCL_19346495_ChIP-Seq_HPC-7_Human1.00144445
130GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.99957849
131E2F1_18555785_ChIP-Seq_MESCs_Mouse0.98006600
132IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.95601354
133POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.95384109
134SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.93997096
135BP1_19119308_ChIP-ChIP_Hs578T_Human0.93990754
136TP63_19390658_ChIP-ChIP_HaCaT_Human0.93273602
137TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.93115017
138PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.92569991
139P300_27058665_Chip-Seq_ZR-75-30cells_Human0.91645730
140DCP1A_22483619_ChIP-Seq_HELA_Human0.91608318
141FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.91531651
142FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90695891
143FOXP1_21924763_ChIP-Seq_HESCs_Human0.90572500
144ELF5_23300383_ChIP-Seq_T47D_Human0.89059654
145GATA1_22383799_ChIP-Seq_G1ME_Mouse0.88723117
146ERG_20887958_ChIP-Seq_HPC-7_Mouse0.88442763
147MYB_26560356_Chip-Seq_TH1_Human0.87738812
148CTCF_18555785_ChIP-Seq_MESCs_Mouse0.87246926
149NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.86753734
150E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.85786519
151NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.85644054
152SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.85386678
153CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.85288650
154MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.85223839
155NOTCH1_21737748_ChIP-Seq_TLL_Human0.84901112
156ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.84866158
157AR_20517297_ChIP-Seq_VCAP_Human0.82696350
158FOXA1_27270436_Chip-Seq_PROSTATE_Human0.80827626
159FOXA1_25329375_ChIP-Seq_VCAP_Human0.80827626
160ESR1_15608294_ChIP-ChIP_MCF-7_Human0.78039410
161MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.74544103
162EGR1_23403033_ChIP-Seq_LIVER_Mouse0.73700933
163NANOG_20526341_ChIP-Seq_ESCs_Human0.70587639
164ERG_20517297_ChIP-Seq_VCAP_Human0.70331534
165NCOR_22424771_ChIP-Seq_293T_Human0.69845919
166EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.68129501

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000372_irregular_coat_pigmentation3.33164320
2MP0010352_gastrointestinal_tract_polyps3.20064402
3MP0003806_abnormal_nucleotide_metabolis3.15674317
4MP0006292_abnormal_olfactory_placode2.98761204
5MP0003705_abnormal_hypodermis_morpholog2.90669867
6MP0003693_abnormal_embryo_hatching2.74076232
7MP0005623_abnormal_meninges_morphology2.65981877
8MP0005076_abnormal_cell_differentiation2.63981842
9MP0004147_increased_porphyrin_level2.58108078
10MP0000490_abnormal_crypts_of2.54364495
11MP0003123_paternal_imprinting2.54181701
12MP0003718_maternal_effect2.50056766
13MP0006036_abnormal_mitochondrial_physio2.49161002
14MP0003111_abnormal_nucleus_morphology2.40237795
15MP0009697_abnormal_copulation2.40151907
16MP0003786_premature_aging2.30702672
17MP0003186_abnormal_redox_activity2.30146053
18MP0009278_abnormal_bone_marrow2.21399732
19MP0002160_abnormal_reproductive_system2.16904824
20MP0010307_abnormal_tumor_latency2.15782605
21MP0005075_abnormal_melanosome_morpholog2.15212205
22MP0010234_abnormal_vibrissa_follicle2.14538398
23MP0004957_abnormal_blastocyst_morpholog2.08354658
24MP0005257_abnormal_intraocular_pressure2.06546787
25MP0008995_early_reproductive_senescence1.97225075
26MP0002938_white_spotting1.96537697
27MP0004808_abnormal_hematopoietic_stem1.96229551
28MP0003077_abnormal_cell_cycle1.93265606
29MP0001764_abnormal_homeostasis1.91337946
30MP0006054_spinal_hemorrhage1.90871252
31MP0010094_abnormal_chromosome_stability1.89752227
32MP0004264_abnormal_extraembryonic_tissu1.88756511
33MP0003303_peritoneal_inflammation1.84912530
34MP0002095_abnormal_skin_pigmentation1.82723984
35MP0008004_abnormal_stomach_pH1.78138316
36MP0002102_abnormal_ear_morphology1.75857998
37MP0002396_abnormal_hematopoietic_system1.70256938
38MP0008789_abnormal_olfactory_epithelium1.68935273
39MP0001986_abnormal_taste_sensitivity1.68619982
40MP0005084_abnormal_gallbladder_morpholo1.67287488
41MP0003300_gastrointestinal_ulcer1.67169829
42MP0010155_abnormal_intestine_physiology1.64815894
43MP0002837_dystrophic_cardiac_calcinosis1.63052811
44MP0005397_hematopoietic_system_phenotyp1.61939426
45MP0001545_abnormal_hematopoietic_system1.61939426
46MP0008438_abnormal_cutaneous_collagen1.59544344
47MP0005646_abnormal_pituitary_gland1.57384212
48MP0006072_abnormal_retinal_apoptosis1.55975228
49MP0008007_abnormal_cellular_replicative1.55964235
50MP0000350_abnormal_cell_proliferation1.54840891
51MP0005023_abnormal_wound_healing1.54365452
52MP0008058_abnormal_DNA_repair1.53917176
53MP0005389_reproductive_system_phenotype1.49867315
54MP0000858_altered_metastatic_potential1.48620353
55MP0003567_abnormal_fetal_cardiomyocyte1.46222503
56MP0006035_abnormal_mitochondrial_morpho1.45854461
57MP0001873_stomach_inflammation1.43588567
58MP0002234_abnormal_pharynx_morphology1.43361669
59MP0002638_abnormal_pupillary_reflex1.42068551
60MP0001188_hyperpigmentation1.41658467
61MP0002086_abnormal_extraembryonic_tissu1.40573187
62MP0005220_abnormal_exocrine_pancreas1.37142836
63MP0000477_abnormal_intestine_morphology1.36379938
64MP0009379_abnormal_foot_pigmentation1.35056854
65MP0005171_absent_coat_pigmentation1.34995758
66MP0003136_yellow_coat_color1.34894576
67MP0004197_abnormal_fetal_growth/weight/1.32718851
68MP0000015_abnormal_ear_pigmentation1.29527491
69MP0008872_abnormal_physiological_respon1.28922209
70MP0003566_abnormal_cell_adhesion1.25961822
71MP0000733_abnormal_muscle_development1.25958505
72MP0000462_abnormal_digestive_system1.25748154
73MP0003448_altered_tumor_morphology1.25078033
74MP0001730_embryonic_growth_arrest1.24177739
75MP0000537_abnormal_urethra_morphology1.21119840
76MP0003866_abnormal_defecation1.20714507
77MP0001697_abnormal_embryo_size1.20658395
78MP0004272_abnormal_basement_membrane1.20422366
79MP0005551_abnormal_eye_electrophysiolog1.19217513
80MP0004510_myositis1.17758025
81MP0003828_pulmonary_edema1.17311821
82MP0004233_abnormal_muscle_weight1.13639804
83MP0005645_abnormal_hypothalamus_physiol1.13246462
84MP0001529_abnormal_vocalization1.10351713
85MP0003091_abnormal_cell_migration1.10299300
86MP0003984_embryonic_growth_retardation1.10242365
87MP0001663_abnormal_digestive_system1.10209770
88MP0003121_genomic_imprinting1.09906424
89MP0001905_abnormal_dopamine_level1.09465936
90MP0001958_emphysema1.09148125
91MP0000681_abnormal_thyroid_gland1.07918522
92MP0002210_abnormal_sex_determination1.07655842
93MP0002080_prenatal_lethality1.07521822
94MP0002085_abnormal_embryonic_tissue1.06439103
95MP0002088_abnormal_embryonic_growth/wei1.05966484
96MP0001929_abnormal_gametogenesis1.05846883
97MP0000516_abnormal_urinary_system1.05320980
98MP0005367_renal/urinary_system_phenotyp1.05320980
99MP0000358_abnormal_cell_content/1.04828050
100MP0002163_abnormal_gland_morphology1.04582202
101MP0010030_abnormal_orbit_morphology1.04541906
102MP0005332_abnormal_amino_acid1.04374517
103MP0001661_extended_life_span1.04308695
104MP0003787_abnormal_imprinting1.04281780
105MP0001849_ear_inflammation1.03682181
106MP0005380_embryogenesis_phenotype1.03554564
107MP0001672_abnormal_embryogenesis/_devel1.03554564
108MP0000653_abnormal_sex_gland1.03137779
109MP0001145_abnormal_male_reproductive1.02942236
110MP0005058_abnormal_lysosome_morphology1.02375245
111MP0003436_decreased_susceptibility_to1.01966792
112MP0009840_abnormal_foam_cell1.01195344
113MP0002925_abnormal_cardiovascular_devel1.00685441
114MP0001293_anophthalmia1.00510656
115MP0000313_abnormal_cell_death1.00272229
116MP0005499_abnormal_olfactory_system0.98715509
117MP0005394_taste/olfaction_phenotype0.98715509
118MP0005381_digestive/alimentary_phenotyp0.98692284
119MP0005410_abnormal_fertilization0.97347981
120MP0010630_abnormal_cardiac_muscle0.96983673
121MP0002452_abnormal_antigen_presenting0.96143977
122MP0000631_abnormal_neuroendocrine_gland0.95895260
123MP0002132_abnormal_respiratory_system0.95430008
124MP0002084_abnormal_developmental_patter0.95236841
125MP0002019_abnormal_tumor_incidence0.92961186
126MP0003878_abnormal_ear_physiology0.91248852
127MP0005377_hearing/vestibular/ear_phenot0.91248852
128MP0005253_abnormal_eye_physiology0.91179150
129MP0002876_abnormal_thyroid_physiology0.90647095
130MP0001879_abnormal_lymphatic_vessel0.90220639
131MP0000534_abnormal_ureter_morphology0.88639243
132MP0005083_abnormal_biliary_tract0.88416661
133MP0006276_abnormal_autonomic_nervous0.88401898
134MP0001119_abnormal_female_reproductive0.87517567
135MP0008770_decreased_survivor_rate0.86854279
136MP0003115_abnormal_respiratory_system0.85396369
137MP0009333_abnormal_splenocyte_physiolog0.85271262
138MP0003315_abnormal_perineum_morphology0.85178840
139MP0008932_abnormal_embryonic_tissue0.82888259
140MP0008875_abnormal_xenobiotic_pharmacok0.82443931
141MP0003698_abnormal_male_reproductive0.80251914
142MP0005636_abnormal_mineral_homeostasis0.79795146
143MP0008057_abnormal_DNA_replication0.79543633
144MP0001968_abnormal_touch/_nociception0.79255228
145MP0002419_abnormal_innate_immunity0.79160562
146MP0008775_abnormal_heart_ventricle0.79059813
147MP0001664_abnormal_digestion0.79059621
148MP0005621_abnormal_cell_physiology0.77645046
149MP0002092_abnormal_eye_morphology0.77246856
150MP0005379_endocrine/exocrine_gland_phen0.77012827
151MP0002736_abnormal_nociception_after0.76152927
152MP0005166_decreased_susceptibility_to0.75845290
153MP0005174_abnormal_tail_pigmentation0.75542053
154MP0002148_abnormal_hypersensitivity_rea0.74823648
155MP0008877_abnormal_DNA_methylation0.74479555
156MP0001915_intracranial_hemorrhage0.74307524
157MP0009053_abnormal_anal_canal0.73674593
158MP0001175_abnormal_lung_morphology0.72969393
159MP0002398_abnormal_bone_marrow0.72338737
160MP0000767_abnormal_smooth_muscle0.72033730
161MP0002233_abnormal_nose_morphology0.71603817
162MP0002006_tumorigenesis0.71536643
163MP0001819_abnormal_immune_cell0.70693640
164MP0002111_abnormal_tail_morphology0.70571053
165MP0004947_skin_inflammation0.70492606
166MP0001919_abnormal_reproductive_system0.70212891
167MP0005408_hypopigmentation0.69660352
168MP0001324_abnormal_eye_pigmentation0.66833508
169MP0002751_abnormal_autonomic_nervous0.66399513
170MP0004142_abnormal_muscle_tone0.64671773
171MP0003119_abnormal_digestive_system0.61485731
172MP0000049_abnormal_middle_ear0.59275455
173MP0002653_abnormal_ependyma_morphology0.58993270
174MP0005501_abnormal_skin_physiology0.58709601

Predicted human phenotypes

RankGene SetZ-score
1Abnormal number of erythroid precursors (HP:0012131)4.60271112
2Mitochondrial inheritance (HP:0001427)4.31341283
3Acute necrotizing encephalopathy (HP:0006965)4.28907333
4Hepatocellular necrosis (HP:0001404)4.24029309
5Increased hepatocellular lipid droplets (HP:0006565)4.14346474
6Acute encephalopathy (HP:0006846)4.12195356
7Increased CSF lactate (HP:0002490)4.06467442
8Hepatic necrosis (HP:0002605)4.03771243
9Lipid accumulation in hepatocytes (HP:0006561)4.00716883
10Abnormal mitochondria in muscle tissue (HP:0008316)3.98000140
11Progressive macrocephaly (HP:0004481)3.70523941
12Protrusio acetabuli (HP:0003179)3.67144525
13Macrocytic anemia (HP:0001972)3.56099612
14Renal Fanconi syndrome (HP:0001994)3.46316697
15Stomatitis (HP:0010280)3.42392018
16Increased intramyocellular lipid droplets (HP:0012240)3.24394568
17Type I transferrin isoform profile (HP:0003642)3.16185487
18Cerebral edema (HP:0002181)3.12788554
19Increased serum lactate (HP:0002151)3.12236912
20Aortic aneurysm (HP:0004942)3.06228841
21Hyperacusis (HP:0010780)3.05924271
22Lactic acidosis (HP:0003128)3.04188690
23Reticulocytopenia (HP:0001896)3.03504655
243-Methylglutaconic aciduria (HP:0003535)2.96009543
25Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.91199564
26Hyperglycinemia (HP:0002154)2.87332194
27Increased muscle lipid content (HP:0009058)2.86410292
28Abnormal protein N-linked glycosylation (HP:0012347)2.82143503
29Abnormal protein glycosylation (HP:0012346)2.82143503
30Abnormal glycosylation (HP:0012345)2.82143503
31Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.82143503
32Renal duplication (HP:0000075)2.81225590
33Colon cancer (HP:0003003)2.79378578
34Cerebral aneurysm (HP:0004944)2.76554042
35Decreased activity of mitochondrial respiratory chain (HP:0008972)2.74019408
36Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.74019408
37Genu recurvatum (HP:0002816)2.67624670
38Hematochezia (HP:0002573)2.64752270
39Methylmalonic acidemia (HP:0002912)2.63679565
40Absent thumb (HP:0009777)2.63303884
41Dicarboxylic aciduria (HP:0003215)2.58516932
42Abnormality of dicarboxylic acid metabolism (HP:0010995)2.58516932
43High anterior hairline (HP:0009890)2.54777283
44Reduced antithrombin III activity (HP:0001976)2.54609957
45Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.54034513
46Microvesicular hepatic steatosis (HP:0001414)2.51126627
47Subacute progressive viral hepatitis (HP:0006572)2.50610773
48Exertional dyspnea (HP:0002875)2.49389654
49Bladder diverticulum (HP:0000015)2.48600735
50Methylmalonic aciduria (HP:0012120)2.46987889
51Lethargy (HP:0001254)2.45576047
52Pancreatic cysts (HP:0001737)2.44265584
53Respiratory failure (HP:0002878)2.42070965
54Abnormality of the phalanges of the hallux (HP:0010057)2.41327662
55Ankle contracture (HP:0006466)2.39807040
56Exercise intolerance (HP:0003546)2.37912611
57Thrombocytosis (HP:0001894)2.36453696
58Type 2 muscle fiber atrophy (HP:0003554)2.36233184
59Autoimmune thrombocytopenia (HP:0001973)2.36032563
60Shallow orbits (HP:0000586)2.35413984
61Agnosia (HP:0010524)2.34049683
62Renovascular hypertension (HP:0100817)2.32303212
63Spondylolisthesis (HP:0003302)2.32257326
64Rectal prolapse (HP:0002035)2.31922904
65Fragile skin (HP:0001030)2.30795824
66Ankyloglossia (HP:0010296)2.30209200
67Pancreatic fibrosis (HP:0100732)2.27985813
68Glycosuria (HP:0003076)2.27210362
69Abnormality of urine glucose concentration (HP:0011016)2.27210362
70Radial bowing (HP:0002986)2.24541700
71Aortic dissection (HP:0002647)2.24371202
72Optic disc pallor (HP:0000543)2.24171465
73Respiratory difficulties (HP:0002880)2.23101245
74Abnormality of renal resorption (HP:0011038)2.20624484
75Recurrent abscess formation (HP:0002722)2.19950054
76Bowel diverticulosis (HP:0005222)2.17481337
77Disinhibition (HP:0000734)2.17370104
78Bicuspid aortic valve (HP:0001647)2.17131665
79Aplastic anemia (HP:0001915)2.15943486
80Chromsome breakage (HP:0040012)2.15271372
81Thin bony cortex (HP:0002753)2.14899349
82Elfin facies (HP:0004428)2.14828445
83Premature rupture of membranes (HP:0001788)2.14221853
84True hermaphroditism (HP:0010459)2.12341100
85Molar tooth sign on MRI (HP:0002419)2.11912524
86Abnormality of midbrain morphology (HP:0002418)2.11912524
87Absent rod-and cone-mediated responses on ERG (HP:0007688)2.09486063
88Neoplasm of the adrenal cortex (HP:0100641)2.09437012
89Vascular tortuosity (HP:0004948)2.08784813
90Congenital stationary night blindness (HP:0007642)2.08550189
91Muscle fiber atrophy (HP:0100295)2.08366866
92Trismus (HP:0000211)2.07090455
93Enlarged penis (HP:0000040)2.06984793
94Dilatation of the ascending aorta (HP:0005111)2.06250504
95Short 4th metacarpal (HP:0010044)2.06230276
96Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.06230276
97Hyperglycinuria (HP:0003108)2.06147291
98Prominent nose (HP:0000448)2.05946867
99Abnormality of serum amino acid levels (HP:0003112)2.04485341
100Arterial tortuosity (HP:0005116)2.03966186
101Cervical subluxation (HP:0003308)2.03261408
102Abnormality of oral frenula (HP:0000190)2.01048137
103Inappropriate behavior (HP:0000719)2.00314734
104Gastrointestinal carcinoma (HP:0002672)1.99352491
105Malignant gastrointestinal tract tumors (HP:0006749)1.99352491
106CNS demyelination (HP:0007305)1.97763820
107Aplasia/Hypoplasia of the sacrum (HP:0008517)1.96977858
108Aplasia/Hypoplasia of the uvula (HP:0010293)1.96500356
109Selective tooth agenesis (HP:0001592)1.96154106
110Abnormality of serine family amino acid metabolism (HP:0010894)1.95948731
111Abnormality of glycine metabolism (HP:0010895)1.95948731
112Abnormality of the 1st metacarpal (HP:0010009)1.94900095
113Abnormal rod and cone electroretinograms (HP:0008323)1.94841165
114Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.94392124
11511 pairs of ribs (HP:0000878)1.92575013
116Flat cornea (HP:0007720)1.92480106
117Meckel diverticulum (HP:0002245)1.91180405
118Microretrognathia (HP:0000308)1.90981813
119Triphalangeal thumb (HP:0001199)1.90883307
120Interstitial pulmonary disease (HP:0006530)1.90548968
121Recurrent bacterial skin infections (HP:0005406)1.90122038
122Nephronophthisis (HP:0000090)1.89891390
123Abnormality of DNA repair (HP:0003254)1.88750098
124Micronodular cirrhosis (HP:0001413)1.87886902
125Mitral valve prolapse (HP:0001634)1.87430882
126Short phalanx of the thumb (HP:0009660)1.85518075
127Abnormality of the ileum (HP:0001549)1.84563129
128Hypoplastic ischia (HP:0003175)1.84358404
129Pancytopenia (HP:0001876)1.84204000
130Pelvic girdle muscle weakness (HP:0003749)1.83961625
131Decreased electroretinogram (ERG) amplitude (HP:0000654)1.83927214
132Aneurysm (HP:0002617)1.83899207
133Deviation of the hallux (HP:0010051)1.83583455
134Abnormality of alanine metabolism (HP:0010916)1.83376030
135Hyperalaninemia (HP:0003348)1.83376030
136Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.83376030
137Acute lymphatic leukemia (HP:0006721)1.83206683
138Abnormality of the preputium (HP:0100587)1.83126499
139Pallor (HP:0000980)1.82884299
140Cellulitis (HP:0100658)1.82481015
141Ketosis (HP:0001946)1.82073740
142Increased serum pyruvate (HP:0003542)1.82066143
143Tubulointerstitial nephritis (HP:0001970)1.82046685
144Short 1st metacarpal (HP:0010034)1.81921704
145Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.81921704
146Abnormality of aspartate family amino acid metabolism (HP:0010899)1.80819851
147Urethral obstruction (HP:0000796)1.79340399
148Wrist flexion contracture (HP:0001239)1.78906011
149Redundant skin (HP:0001582)1.78706030
150Chromosomal breakage induced by crosslinking agents (HP:0003221)1.78703829
151Abnormality of the heme biosynthetic pathway (HP:0010472)1.78667073
152Neoplasm of the adrenal gland (HP:0100631)1.78541974
153Medial flaring of the eyebrow (HP:0010747)1.76605893
154Hallux valgus (HP:0001822)1.76275216
155Hyperammonemia (HP:0001987)1.76209613
156Neoplasm of the oral cavity (HP:0100649)1.76165984
157Attenuation of retinal blood vessels (HP:0007843)1.76079416
158Sclerocornea (HP:0000647)1.76046180
159Viral hepatitis (HP:0006562)1.75710274
160Abnormality of methionine metabolism (HP:0010901)1.75218798
161Abnormality of the fingertips (HP:0001211)1.75002023
162Soft skin (HP:0000977)1.74250111
163Slender long bone (HP:0003100)1.74073011
164Emotional lability (HP:0000712)1.73146225
165Renal cortical cysts (HP:0000803)1.73133706
166Metabolic acidosis (HP:0001942)1.72954309
167Absent frontal sinuses (HP:0002688)1.72534407
168Increased density of long bones (HP:0006392)1.71884615
169Increased cerebral lipofuscin (HP:0011813)1.71574329
170Abnormality of the distal phalanx of the thumb (HP:0009617)1.71366331
171Ependymoma (HP:0002888)1.71324604
172Neoplasm of the pancreas (HP:0002894)1.71131088
173Panhypogammaglobulinemia (HP:0003139)1.70726031
174Abnormality of cells of the erythroid lineage (HP:0012130)1.70459968
175Overriding aorta (HP:0002623)1.70132532
176Stenosis of the external auditory canal (HP:0000402)1.69961878
177Missing ribs (HP:0000921)1.69598765
178Uterine neoplasm (HP:0010784)1.68925219
179Biliary tract neoplasm (HP:0100574)1.67968320
180Severe short stature (HP:0003510)1.66294155
181Myelodysplasia (HP:0002863)1.65873686
182Ileus (HP:0002595)1.65838810
183Patellar aplasia (HP:0006443)1.64645147
184Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.64139913
185Atrophic scars (HP:0001075)1.62356474
186Increased nuchal translucency (HP:0010880)1.61128400
187Abnormality of the carotid arteries (HP:0005344)1.59174887
188Nausea (HP:0002018)1.59120556
189Episodic fever (HP:0001954)1.57839934
190Apathy (HP:0000741)1.56522295
191Diminished motivation (HP:0000745)1.56404758
192Heterotopia (HP:0002282)1.55271769

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK25.07243459
2EPHA24.39288372
3PKN24.06218373
4STK163.60963385
5CDK123.53939700
6TRIB33.44297228
7TLK13.43325163
8NUAK13.36775440
9ERN13.18955211
10SCYL23.09814504
11BCKDK2.95624064
12EEF2K2.74269455
13NEK12.57383021
14EIF2AK32.56915641
15CDC72.12956613
16TAF12.05369299
17NEK22.04933587
18NME21.97917503
19BMPR1B1.95832665
20MAP4K21.95816739
21EIF2AK11.92532654
22MAP3K101.72451982
23FLT31.71127160
24CDK191.69978531
25MST1R1.69419479
26TAOK11.64569813
27BRD41.62955250
28FRK1.56838602
29TAOK31.55862996
30RPS6KA41.52569787
31MKNK11.51394059
32DYRK31.50907172
33MST41.49698388
34LMTK21.46607686
35PAK41.40623286
36MAPKAPK51.40441271
37CSNK1G31.35667578
38KSR21.35070640
39PTK61.30458710
40GRK11.27902994
41VRK11.27691503
42TTN1.26692523
43BMX1.24389470
44TBK11.21312510
45PLK31.20487683
46NME11.19354105
47ZAK1.18352245
48DYRK21.14518279
49BLK1.13363909
50DAPK31.13263073
51DMPK1.12715605
52LRRK21.12448264
53CDK71.11153458
54CSNK1G11.10126213
55MAP3K81.09765264
56WEE11.05970503
57RPS6KB21.05580671
58CSNK1A1L1.05507037
59PDK21.05281871
60ILK1.05112880
61CCNB11.04418822
62CAMK1D1.03853989
63DDR21.03306676
64BRSK21.02847146
65CSNK1G20.98918434
66MELK0.98278984
67STK40.98106122
68AURKB0.98067030
69PRKG20.97124939
70PDGFRA0.97123701
71CHEK20.95267268
72CDK40.95169668
73ALK0.94120171
74MAP4K10.93438682
75WNK40.93341850
76TTK0.92118546
77ADRBK20.91817138
78PAK20.91578702
79LATS10.91132407
80STK390.90969012
81RIPK10.89983241
82PRKCI0.89061310
83KIT0.88943269
84CDK90.87923007
85DAPK10.87161434
86PINK10.87001113
87JAK30.86841916
88IRAK30.86302301
89ERBB30.85321527
90EIF2AK20.84302739
91TESK20.81386069
92PLK20.80706797
93TRIM280.80046896
94STK30.75471110
95MATK0.73661863
96RIPK40.72996824
97TEC0.70805358
98EPHB20.70737435
99OXSR10.70477103
100WNK30.67924755
101MKNK20.67800176
102MAP2K20.67558314
103KSR10.67022489
104INSRR0.65942265
105MUSK0.65243209
106ATR0.64772662
107PLK10.64376281
108CDK80.64160134
109CSF1R0.64153741
110MAP2K70.61845131
111ACVR1B0.61506218
112PIM10.61331495
113MTOR0.57756297
114CSNK2A20.57238565
115MAPK130.56232832
116SMG10.55549496
117PRKD30.54711827
118MET0.54521888
119GRK60.53458245
120FGR0.53230147
121KDR0.53015454
122RAF10.52877161
123CSNK2A10.52498498
124ERBB40.51365021
125AURKA0.50980452
126MAP3K90.49549283
127ATM0.48143626
128ADRBK10.47631506
129PLK40.47193338
130TNIK0.46551071
131CDK60.46472689
132PAK10.46203934
133AKT20.44943652
134GRK50.44644867
135RPS6KA50.43610168
136TGFBR20.41362197
137MAP3K70.40857063
138SRPK10.38443289
139PHKG10.37835485
140PHKG20.37835485
141MAP2K30.37496011
142MAP3K110.37142413
143RET0.36911566
144RPS6KB10.36432623
145PAK60.35704620
146CDK20.35138463
147MAP3K120.34580934
148IKBKB0.33789066
149TIE10.33354810
150MAP3K130.33334843
151PBK0.32505641
152BUB10.32459131
153TGFBR10.31678695
154CAMKK10.31031133
155EGFR0.30345197
156ABL20.30209381
157MAP3K40.29253322
158PIM20.29013461
159MAPKAPK30.28716967
160CSNK1A10.28467513
161PRKCQ0.28147655
162PASK0.27550088
163CDK30.26706401

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.18535487
2Proteasome_Homo sapiens_hsa030502.97013006
3DNA replication_Homo sapiens_hsa030302.83171809
4Parkinsons disease_Homo sapiens_hsa050122.82389352
5RNA polymerase_Homo sapiens_hsa030202.71481356
6Mismatch repair_Homo sapiens_hsa034302.71224559
7Systemic lupus erythematosus_Homo sapiens_hsa053222.54654343
8Protein export_Homo sapiens_hsa030602.41714987
9Ribosome_Homo sapiens_hsa030102.07339373
10Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.04246161
11Homologous recombination_Homo sapiens_hsa034402.03733366
12Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.91738105
13Huntingtons disease_Homo sapiens_hsa050161.90669436
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.89869243
15Non-homologous end-joining_Homo sapiens_hsa034501.84805607
16Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.84357115
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.75867954
18Propanoate metabolism_Homo sapiens_hsa006401.71784120
19Alzheimers disease_Homo sapiens_hsa050101.68919779
20Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.67068100
21RNA degradation_Homo sapiens_hsa030181.60797833
22Chronic myeloid leukemia_Homo sapiens_hsa052201.58403483
23Base excision repair_Homo sapiens_hsa034101.54991739
24Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.54610240
25Leishmaniasis_Homo sapiens_hsa051401.51768394
26Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.49871594
27Basal transcription factors_Homo sapiens_hsa030221.47394242
28Cell cycle_Homo sapiens_hsa041101.46444166
29Alcoholism_Homo sapiens_hsa050341.45978467
30Purine metabolism_Homo sapiens_hsa002301.40845714
31Bladder cancer_Homo sapiens_hsa052191.36611172
32Fatty acid elongation_Homo sapiens_hsa000621.35113790
33Small cell lung cancer_Homo sapiens_hsa052221.34518695
34NOD-like receptor signaling pathway_Homo sapiens_hsa046211.32487920
35B cell receptor signaling pathway_Homo sapiens_hsa046621.28504939
36Glutathione metabolism_Homo sapiens_hsa004801.26880389
37Viral carcinogenesis_Homo sapiens_hsa052031.26167734
38Sulfur relay system_Homo sapiens_hsa041221.26005303
39Pancreatic cancer_Homo sapiens_hsa052121.22919255
40Butanoate metabolism_Homo sapiens_hsa006501.22777130
41Cysteine and methionine metabolism_Homo sapiens_hsa002701.21873922
42Nucleotide excision repair_Homo sapiens_hsa034201.21492466
43Peroxisome_Homo sapiens_hsa041461.20659083
44AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.18949843
45Salmonella infection_Homo sapiens_hsa051321.18408984
46MicroRNAs in cancer_Homo sapiens_hsa052061.15720398
47Herpes simplex infection_Homo sapiens_hsa051681.14257785
48TNF signaling pathway_Homo sapiens_hsa046681.13164602
49Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.11920659
50Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.11080529
51p53 signaling pathway_Homo sapiens_hsa041151.10083854
52Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.09689160
53Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.08916740
54Osteoclast differentiation_Homo sapiens_hsa043801.06909294
55Renin-angiotensin system_Homo sapiens_hsa046141.04345073
56Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.04262890
57Adherens junction_Homo sapiens_hsa045201.03753558
58Pyruvate metabolism_Homo sapiens_hsa006201.02943755
59Transcriptional misregulation in cancer_Homo sapiens_hsa052021.02634617
60Legionellosis_Homo sapiens_hsa051341.01127567
61Apoptosis_Homo sapiens_hsa042101.00403952
62Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.00129344
63Hepatitis B_Homo sapiens_hsa051611.00127079
64Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.00100418
65Proteoglycans in cancer_Homo sapiens_hsa052050.99885843
66Central carbon metabolism in cancer_Homo sapiens_hsa052300.99789730
67Shigellosis_Homo sapiens_hsa051310.99679072
68Glioma_Homo sapiens_hsa052140.99250281
69Sulfur metabolism_Homo sapiens_hsa009200.97534095
70Leukocyte transendothelial migration_Homo sapiens_hsa046700.96971209
71Influenza A_Homo sapiens_hsa051640.96475485
72Metabolic pathways_Homo sapiens_hsa011000.96029994
73Selenocompound metabolism_Homo sapiens_hsa004500.95595553
74HTLV-I infection_Homo sapiens_hsa051660.95557987
75VEGF signaling pathway_Homo sapiens_hsa043700.95347364
76Fanconi anemia pathway_Homo sapiens_hsa034600.94963657
77Carbohydrate digestion and absorption_Homo sapiens_hsa049730.94836904
78Colorectal cancer_Homo sapiens_hsa052100.94644720
79Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.94582999
80Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.94079486
81Acute myeloid leukemia_Homo sapiens_hsa052210.93855616
82Toxoplasmosis_Homo sapiens_hsa051450.93452331
832-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.92579605
84HIF-1 signaling pathway_Homo sapiens_hsa040660.92409433
85One carbon pool by folate_Homo sapiens_hsa006700.92273325
86Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.91988480
87Non-small cell lung cancer_Homo sapiens_hsa052230.91317433
88Focal adhesion_Homo sapiens_hsa045100.91249126
89Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.88453484
90Toll-like receptor signaling pathway_Homo sapiens_hsa046200.88431121
91Tuberculosis_Homo sapiens_hsa051520.88295961
92Cardiac muscle contraction_Homo sapiens_hsa042600.87953598
93Protein digestion and absorption_Homo sapiens_hsa049740.87296310
94Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.86989482
95RNA transport_Homo sapiens_hsa030130.86491357
96Pertussis_Homo sapiens_hsa051330.85428290
97Nitrogen metabolism_Homo sapiens_hsa009100.85044391
98TGF-beta signaling pathway_Homo sapiens_hsa043500.85022544
99Spliceosome_Homo sapiens_hsa030400.84234622
100alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.83197830
101Galactose metabolism_Homo sapiens_hsa000520.81823399
102Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.80525551
103Carbon metabolism_Homo sapiens_hsa012000.80395545
104Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.80188386
105Antigen processing and presentation_Homo sapiens_hsa046120.79724145
106Folate biosynthesis_Homo sapiens_hsa007900.78890060
107Hippo signaling pathway_Homo sapiens_hsa043900.78523820
108Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.78402658
109Phototransduction_Homo sapiens_hsa047440.76852090
110Linoleic acid metabolism_Homo sapiens_hsa005910.76540341
111Neurotrophin signaling pathway_Homo sapiens_hsa047220.76443213
112Pentose and glucuronate interconversions_Homo sapiens_hsa000400.76120236
113Platelet activation_Homo sapiens_hsa046110.75567492
114Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.75382693
115Pyrimidine metabolism_Homo sapiens_hsa002400.74122793
116Mineral absorption_Homo sapiens_hsa049780.73483356
117Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.71591225
118Endometrial cancer_Homo sapiens_hsa052130.70627397
119Tryptophan metabolism_Homo sapiens_hsa003800.70277676
120Chemical carcinogenesis_Homo sapiens_hsa052040.69688420
121Lysine degradation_Homo sapiens_hsa003100.69637545
122NF-kappa B signaling pathway_Homo sapiens_hsa040640.68935005
123Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.68130836
124Maturity onset diabetes of the young_Homo sapiens_hsa049500.68120213
125Asthma_Homo sapiens_hsa053100.67856802
126Malaria_Homo sapiens_hsa051440.67785047
127Thyroid cancer_Homo sapiens_hsa052160.67675118
128Notch signaling pathway_Homo sapiens_hsa043300.67595360
129Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.67233826
130Fatty acid degradation_Homo sapiens_hsa000710.66658694
131Biosynthesis of amino acids_Homo sapiens_hsa012300.66088412
132Arachidonic acid metabolism_Homo sapiens_hsa005900.66022258
133ECM-receptor interaction_Homo sapiens_hsa045120.65880896
134mRNA surveillance pathway_Homo sapiens_hsa030150.65366889
135mTOR signaling pathway_Homo sapiens_hsa041500.65177856
136Drug metabolism - other enzymes_Homo sapiens_hsa009830.64891941
137Fat digestion and absorption_Homo sapiens_hsa049750.64586293
138Steroid hormone biosynthesis_Homo sapiens_hsa001400.64466753
139Amoebiasis_Homo sapiens_hsa051460.63510190
140Renal cell carcinoma_Homo sapiens_hsa052110.63446333
141N-Glycan biosynthesis_Homo sapiens_hsa005100.62924269
142Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.60456882
143Pathways in cancer_Homo sapiens_hsa052000.60120160
144Tight junction_Homo sapiens_hsa045300.59076930
145Fructose and mannose metabolism_Homo sapiens_hsa000510.58540923
146Fatty acid metabolism_Homo sapiens_hsa012120.58148231
147Basal cell carcinoma_Homo sapiens_hsa052170.57360554
148SNARE interactions in vesicular transport_Homo sapiens_hsa041300.56936984
149Glycosaminoglycan degradation_Homo sapiens_hsa005310.56219215
150Prostate cancer_Homo sapiens_hsa052150.55674997
151Melanoma_Homo sapiens_hsa052180.54396523
152Other glycan degradation_Homo sapiens_hsa005110.54300913
153FoxO signaling pathway_Homo sapiens_hsa040680.53599792
154Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.53551020
155Epstein-Barr virus infection_Homo sapiens_hsa051690.53485529
156Retinol metabolism_Homo sapiens_hsa008300.51659754
157Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.50402129
158Pentose phosphate pathway_Homo sapiens_hsa000300.49427832
159Ether lipid metabolism_Homo sapiens_hsa005650.48955075
160Regulation of autophagy_Homo sapiens_hsa041400.47681235
161Steroid biosynthesis_Homo sapiens_hsa001000.47618740
162Vitamin digestion and absorption_Homo sapiens_hsa049770.45335527
163Tyrosine metabolism_Homo sapiens_hsa003500.42338365
164Cyanoamino acid metabolism_Homo sapiens_hsa004600.40483783
165Intestinal immune network for IgA production_Homo sapiens_hsa046720.36716731
166Caffeine metabolism_Homo sapiens_hsa002320.33815634
167Vitamin B6 metabolism_Homo sapiens_hsa007500.32537067
168Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.30101701
169Primary bile acid biosynthesis_Homo sapiens_hsa001200.29524512
170beta-Alanine metabolism_Homo sapiens_hsa004100.28645907
171Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.27900559
172Arginine and proline metabolism_Homo sapiens_hsa003300.27621583
173Olfactory transduction_Homo sapiens_hsa047400.26562122
174Collecting duct acid secretion_Homo sapiens_hsa049660.25509326
175Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.24151459

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