LRRC75B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuron cell-cell adhesion (GO:0007158)4.86892682
2cell migration in hindbrain (GO:0021535)4.51828690
3regulation of short-term neuronal synaptic plasticity (GO:0048172)4.51161015
4vocalization behavior (GO:0071625)4.33837451
5regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.16521958
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.04892008
7positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.03898307
8synaptic vesicle exocytosis (GO:0016079)3.88824806
9regulation of synaptic vesicle exocytosis (GO:2000300)3.87165543
10layer formation in cerebral cortex (GO:0021819)3.82654777
11protein localization to synapse (GO:0035418)3.81981712
12locomotory exploration behavior (GO:0035641)3.81474154
13neuronal action potential propagation (GO:0019227)3.77378494
14synaptic vesicle maturation (GO:0016188)3.76599856
15phospholipid efflux (GO:0033700)3.69595419
16ionotropic glutamate receptor signaling pathway (GO:0035235)3.68659034
17regulation of cholesterol esterification (GO:0010872)3.67675131
18regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.65873264
19dendritic spine morphogenesis (GO:0060997)3.65746857
20regulation of glutamate receptor signaling pathway (GO:1900449)3.65234132
21regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.64455620
22neuron recognition (GO:0008038)3.61087263
23negative regulation of microtubule polymerization (GO:0031115)3.60223217
24cell-cell junction maintenance (GO:0045217)3.59848906
25positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.59734712
26dendrite morphogenesis (GO:0048813)3.54522576
27presynaptic membrane assembly (GO:0097105)3.50727039
28response to pheromone (GO:0019236)3.50626863
29glutamate secretion (GO:0014047)3.49992875
30protein carboxylation (GO:0018214)3.49728464
31peptidyl-glutamic acid carboxylation (GO:0017187)3.49728464
32negative regulation of cholesterol transport (GO:0032375)3.45906628
33negative regulation of sterol transport (GO:0032372)3.45906628
34positive regulation of synaptic transmission, GABAergic (GO:0032230)3.35286166
35exploration behavior (GO:0035640)3.35129567
36proline transport (GO:0015824)3.31110125
37regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.30572137
38presynaptic membrane organization (GO:0097090)3.30330341
39high-density lipoprotein particle remodeling (GO:0034375)3.29985332
40semaphorin-plexin signaling pathway (GO:0071526)3.28317262
41regulation of synaptic vesicle transport (GO:1902803)3.28316620
42negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.27378163
43gamma-aminobutyric acid transport (GO:0015812)3.26782161
44transmission of nerve impulse (GO:0019226)3.26509801
45postsynaptic membrane organization (GO:0001941)3.26131377
46proline metabolic process (GO:0006560)3.25979354
47axonal fasciculation (GO:0007413)3.25825247
48synaptic transmission, glutamatergic (GO:0035249)3.25811004
49neurotransmitter secretion (GO:0007269)3.24117858
50glutamate receptor signaling pathway (GO:0007215)3.23421161
51negative regulation of lipase activity (GO:0060192)3.20488560
52plasma lipoprotein particle assembly (GO:0034377)3.20026684
53positive regulation of synapse assembly (GO:0051965)3.16965112
54neuron-neuron synaptic transmission (GO:0007270)3.13598581
55pyrimidine nucleobase catabolic process (GO:0006208)3.12385396
56cerebellar Purkinje cell differentiation (GO:0021702)3.12332412
57neurofilament cytoskeleton organization (GO:0060052)3.12092403
58reverse cholesterol transport (GO:0043691)3.10961431
59synaptic vesicle docking involved in exocytosis (GO:0016081)3.10694569
60regulation of synapse structural plasticity (GO:0051823)3.10379265
61central nervous system myelination (GO:0022010)3.09320204
62axon ensheathment in central nervous system (GO:0032291)3.09320204
63regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.09168048
64detection of temperature stimulus involved in sensory perception of pain (GO:0050965)3.08803052
65detection of temperature stimulus involved in sensory perception (GO:0050961)3.08803052
66regulation of respiratory system process (GO:0044065)3.08317946
67regulation of plasminogen activation (GO:0010755)3.06064909
68detection of temperature stimulus (GO:0016048)3.05940743
69plasma lipoprotein particle remodeling (GO:0034369)3.03996124
70protein-lipid complex remodeling (GO:0034368)3.03996124
71macromolecular complex remodeling (GO:0034367)3.03996124
72membrane hyperpolarization (GO:0060081)3.03797326
73regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.03460659
74erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.02235418
75L-phenylalanine catabolic process (GO:0006559)3.02235418
76central nervous system projection neuron axonogenesis (GO:0021952)3.01292775
77membrane depolarization during action potential (GO:0086010)3.00693358
78positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.00475225
79cell junction maintenance (GO:0034331)2.99170665
80innervation (GO:0060384)2.98267924
81membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.98104904
82synapse assembly (GO:0007416)2.96922132
83neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.96549267
84glycine transport (GO:0015816)2.93434981
85neuronal action potential (GO:0019228)2.93007648
86neuronal ion channel clustering (GO:0045161)2.92917448
87response to auditory stimulus (GO:0010996)2.90811655
88glyoxylate metabolic process (GO:0046487)2.90537340
89planar cell polarity pathway involved in neural tube closure (GO:0090179)2.88358263
90regulation of synaptic transmission, glutamatergic (GO:0051966)2.88170951
91epoxygenase P450 pathway (GO:0019373)2.87664910
92regulation of respiratory gaseous exchange (GO:0043576)2.87403666
93cerebral cortex radially oriented cell migration (GO:0021799)2.86314182
94neurotransmitter transport (GO:0006836)2.86114284
95regulation of fibrinolysis (GO:0051917)2.84920712
96prepulse inhibition (GO:0060134)2.84888192
97L-phenylalanine metabolic process (GO:0006558)2.84871828
98erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.84871828
99negative regulation of catenin import into nucleus (GO:0035414)2.84352620
100mating behavior (GO:0007617)2.81969447
101negative regulation of fibrinolysis (GO:0051918)2.81795189
102regulation of neurotransmitter secretion (GO:0046928)2.81211698
103negative regulation of synaptic transmission, GABAergic (GO:0032229)2.79690234
104axon cargo transport (GO:0008088)2.79083229
105protein-lipid complex assembly (GO:0065005)2.79010987
106cellular potassium ion homeostasis (GO:0030007)2.77842684
107regulation of cholesterol biosynthetic process (GO:0045540)2.76099232
1084-hydroxyproline metabolic process (GO:0019471)2.75909655
109regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.75529598
110establishment of mitochondrion localization (GO:0051654)2.74128083
111regulation of cholesterol metabolic process (GO:0090181)2.72373137
112adult walking behavior (GO:0007628)2.72271706
113synaptic vesicle endocytosis (GO:0048488)2.72123904
114regulation of synaptic transmission, GABAergic (GO:0032228)2.71817479
115low-density lipoprotein particle remodeling (GO:0034374)2.71808596
116regulation of synapse assembly (GO:0051963)2.71525157
117central nervous system neuron axonogenesis (GO:0021955)2.70831680
118positive regulation of lipoprotein lipase activity (GO:0051006)2.70688012
119positive regulation of triglyceride lipase activity (GO:0061365)2.70688012
120regulation of neuronal synaptic plasticity (GO:0048168)2.69340368
121auditory behavior (GO:0031223)2.68841740
122gamma-aminobutyric acid signaling pathway (GO:0007214)2.67787935
123retinal ganglion cell axon guidance (GO:0031290)2.66747263
124membrane depolarization (GO:0051899)2.66191324
125cholesterol efflux (GO:0033344)2.66126846
126protein retention in ER lumen (GO:0006621)2.65833524
127synapse organization (GO:0050808)2.65772628
128negative regulation of axonogenesis (GO:0050771)2.65651116
129fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.65246798
130regulation of vesicle fusion (GO:0031338)2.65230282
131negative regulation of axon extension (GO:0030517)2.64925248
132regulation of excitatory postsynaptic membrane potential (GO:0060079)2.64704545
133regulation of postsynaptic membrane potential (GO:0060078)2.64122762
134positive regulation of potassium ion transmembrane transport (GO:1901381)2.63914322
135very-low-density lipoprotein particle assembly (GO:0034379)2.63696950
136organelle transport along microtubule (GO:0072384)2.62897260
137long-term memory (GO:0007616)2.62056315
138drug catabolic process (GO:0042737)2.61729686
139neurotransmitter-gated ion channel clustering (GO:0072578)2.61247669
140endothelial cell chemotaxis (GO:0035767)2.61202470
141plasma lipoprotein particle organization (GO:0071827)2.61126418
142diacylglycerol metabolic process (GO:0046339)2.60621850
143neuron projection extension involved in neuron projection guidance (GO:1902284)2.60295260
144axon extension involved in axon guidance (GO:0048846)2.60295260
145positive regulation of action potential (GO:0045760)2.60166710
146axon extension (GO:0048675)2.59011706
147regulation of neurotransmitter transport (GO:0051588)2.56854978
148vesicle transport along microtubule (GO:0047496)2.54584668
149mitochondrion transport along microtubule (GO:0047497)2.51533011
150establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.51533011
151arginine catabolic process (GO:0006527)2.50455942
152convergent extension (GO:0060026)2.48946789
153regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.48174048
154lung epithelium development (GO:0060428)2.47834386
155plasma lipoprotein particle clearance (GO:0034381)2.47572073
156complement activation, alternative pathway (GO:0006957)2.45745970
157negative regulation of telomerase activity (GO:0051974)2.45681465
158cellular modified amino acid catabolic process (GO:0042219)2.44223486
159biotin metabolic process (GO:0006768)2.43148815
160protein-lipid complex subunit organization (GO:0071825)2.42323932
161response to acidic pH (GO:0010447)2.40220370
162atrioventricular valve morphogenesis (GO:0003181)2.37201803
163exogenous drug catabolic process (GO:0042738)2.36471873
164regulation of protein activation cascade (GO:2000257)2.35493755
165cellular response to pH (GO:0071467)2.33753884
166iron coordination entity transport (GO:1901678)2.33455793
167regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.32423732
168proline biosynthetic process (GO:0006561)2.32065476
169dendritic spine organization (GO:0097061)2.31795473
170maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.30670370
171intestinal cholesterol absorption (GO:0030299)2.30457545
172heart valve formation (GO:0003188)2.28324229
173urea metabolic process (GO:0019627)2.28318579
174response to misfolded protein (GO:0051788)2.28089775
175cochlea morphogenesis (GO:0090103)2.27917355
176regulation of cholesterol homeostasis (GO:2000188)2.27615283
177regulation of complement activation (GO:0030449)2.27478790
178acetyl-CoA metabolic process (GO:0006084)2.27460654
179camera-type eye morphogenesis (GO:0048593)2.25100627
180positive regulation of lipid catabolic process (GO:0050996)2.24922149
181renal system development (GO:0072001)2.24123622
182renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)2.23205279
183glutathione biosynthetic process (GO:0006750)2.22960343
184regulation of apoptotic cell clearance (GO:2000425)2.22070585
185arginine metabolic process (GO:0006525)2.21543503
186regulation of systemic arterial blood pressure (GO:0003073)2.19264504
187nonribosomal peptide biosynthetic process (GO:0019184)2.18913870
188cranial nerve morphogenesis (GO:0021602)2.18356082
189urea cycle (GO:0000050)2.18164288

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.06933869
2EZH2_22144423_ChIP-Seq_EOC_Human4.88135166
3GBX2_23144817_ChIP-Seq_PC3_Human3.41555475
4TP63_17297297_ChIP-ChIP_HaCaT_Human3.06221931
5THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.00028138
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.96730484
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.89733478
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.88967536
9ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.88248834
10LXR_22292898_ChIP-Seq_THP-1_Human2.75641727
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.73834995
12RNF2_18974828_ChIP-Seq_MESCs_Mouse2.66737301
13EZH2_18974828_ChIP-Seq_MESCs_Mouse2.66737301
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.64393146
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.53369959
16GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.49105982
17SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.47673271
18EED_16625203_ChIP-ChIP_MESCs_Mouse2.46945136
19SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.42877778
20PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.38410062
21MTF2_20144788_ChIP-Seq_MESCs_Mouse2.32995056
22SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.28684327
23EZH2_27294783_Chip-Seq_ESCs_Mouse2.25437156
24SUZ12_27294783_Chip-Seq_ESCs_Mouse2.20945152
25RARG_19884340_ChIP-ChIP_MEFs_Mouse2.18289967
26RNF2_27304074_Chip-Seq_ESCs_Mouse2.16437693
27REST_21632747_ChIP-Seq_MESCs_Mouse2.09323526
28KDM2B_26808549_Chip-Seq_K562_Human2.08650507
29TAF15_26573619_Chip-Seq_HEK293_Human2.05468646
30AR_21572438_ChIP-Seq_LNCaP_Human2.05360392
31CTCF_27219007_Chip-Seq_Bcells_Human2.03831027
32ESR2_21235772_ChIP-Seq_MCF-7_Human2.01084624
33DROSHA_22980978_ChIP-Seq_HELA_Human1.97419000
34RACK7_27058665_Chip-Seq_MCF-7_Human1.96080879
35ZFP281_18757296_ChIP-ChIP_E14_Mouse1.96054486
36CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.93901738
37NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.92495358
38CBX2_27304074_Chip-Seq_ESCs_Mouse1.91231497
39BMI1_23680149_ChIP-Seq_NPCS_Mouse1.90854850
40CTBP2_25329375_ChIP-Seq_LNCAP_Human1.90140758
41RXR_22158963_ChIP-Seq_LIVER_Mouse1.81568791
42TET1_21451524_ChIP-Seq_MESCs_Mouse1.80740774
43ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.80330269
44EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.78290353
45SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.77175973
46DNAJC2_21179169_ChIP-ChIP_NT2_Human1.76956182
47PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.76505503
48P68_20966046_ChIP-Seq_HELA_Human1.76129644
49ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.73190976
50KDM2B_26808549_Chip-Seq_SUP-B15_Human1.72000039
51CDX2_19796622_ChIP-Seq_MESCs_Mouse1.68095100
52ZFP57_27257070_Chip-Seq_ESCs_Mouse1.67506259
53PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.67086075
54PPARA_22158963_ChIP-Seq_LIVER_Mouse1.67064854
55CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.63894948
56SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.62626103
57SMC4_20622854_ChIP-Seq_HELA_Human1.62240199
58REST_18959480_ChIP-ChIP_MESCs_Mouse1.61721573
59IKZF1_21737484_ChIP-ChIP_HCT116_Human1.60902205
60RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.59352358
61CTBP1_25329375_ChIP-Seq_LNCAP_Human1.57518959
62SMAD4_21799915_ChIP-Seq_A2780_Human1.57309018
63ELK3_25401928_ChIP-Seq_HUVEC_Human1.56218408
64ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.56096671
65CREB1_26743006_Chip-Seq_LNCaP_Human1.53858530
66UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.51880857
67ESR1_15608294_ChIP-ChIP_MCF-7_Human1.50672235
68RNF2_27304074_Chip-Seq_NSC_Mouse1.48707982
69P300_19829295_ChIP-Seq_ESCs_Human1.47364755
70TRIM28_21343339_ChIP-Seq_HEK293_Human1.46850436
71SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.45503430
72PIAS1_25552417_ChIP-Seq_VCAP_Human1.44772481
73OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.44619187
74SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.43997823
75TOP2B_26459242_ChIP-Seq_MCF-7_Human1.43690344
76SA1_27219007_Chip-Seq_ERYTHROID_Human1.43527019
77ERG_21242973_ChIP-ChIP_JURKAT_Human1.39272848
78RARB_27405468_Chip-Seq_BRAIN_Mouse1.39185995
79ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.38922685
80WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.38433436
81SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37974067
82SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37848294
83ZFP281_27345836_Chip-Seq_ESCs_Mouse1.33786367
84SRY_22984422_ChIP-ChIP_TESTIS_Rat1.33769098
85KDM2B_26808549_Chip-Seq_DND41_Human1.31596082
86ZNF263_19887448_ChIP-Seq_K562_Human1.31120031
87TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.30132379
88RING1B_27294783_Chip-Seq_ESCs_Mouse1.29675798
89TP53_22127205_ChIP-Seq_IMR90_Human1.29381836
90SMAD3_21741376_ChIP-Seq_EPCs_Human1.28228087
91SMAD_19615063_ChIP-ChIP_OVARY_Human1.27942602
92AHR_22903824_ChIP-Seq_MCF-7_Human1.27938922
93ZNF217_24962896_ChIP-Seq_MCF-7_Human1.27732053
94KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.27173187
95NR3C1_23031785_ChIP-Seq_PC12_Mouse1.26841512
96MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.26644081
97ZNF274_21170338_ChIP-Seq_K562_Hela1.26427790
98SOX2_21211035_ChIP-Seq_LN229_Gbm1.25420993
99POU3F2_20337985_ChIP-ChIP_501MEL_Human1.25243564
100TET1_21490601_ChIP-Seq_MESCs_Mouse1.24970303
101CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.24492689
102ARNT_22903824_ChIP-Seq_MCF-7_Human1.24473729
103VDR_21846776_ChIP-Seq_THP-1_Human1.24404718
104RING1B_27294783_Chip-Seq_NPCs_Mouse1.24114715
105P53_22127205_ChIP-Seq_FIBROBLAST_Human1.22511759
106AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.21754438
107EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.19232456
108CTCF_27219007_Chip-Seq_ERYTHROID_Human1.18528213
109STAT3_23295773_ChIP-Seq_U87_Human1.18346952
110AR_25329375_ChIP-Seq_VCAP_Human1.18037908
111NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.18011525
112FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.17587782
113GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16663716
114CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.16637252
115TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14516734
116RARB_24833708_ChIP-Seq_LIVER_Mouse1.13131256
117NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.12295616
118TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.12215050
119TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11898725
120BCOR_27268052_Chip-Seq_Bcells_Human1.11881502
121BCL6_27268052_Chip-Seq_Bcells_Human1.11162446
122PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.10055080
123SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.09684645
124VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.08274987
125RARA_24833708_ChIP-Seq_LIVER_Mouse1.07873971
126TP63_22573176_ChIP-Seq_HFKS_Human1.07745732
127POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.07716450
128TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07716450
129AR_19668381_ChIP-Seq_PC3_Human1.07689876
130POU5F1_16518401_ChIP-PET_MESCs_Mouse1.07151639
131ER_23166858_ChIP-Seq_MCF-7_Human1.06922155
132IGF1R_20145208_ChIP-Seq_DFB_Human1.06174549
133UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.05387872
134TCF4_23295773_ChIP-Seq_U87_Human1.04692160
135PHF8_20622854_ChIP-Seq_HELA_Human1.04606755
136WT1_25993318_ChIP-Seq_PODOCYTE_Human1.04140352
137YAP1_20516196_ChIP-Seq_MESCs_Mouse1.04044409
138CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03938680
139SOX3_22085726_ChIP-Seq_NPCs_Mouse1.03419705
140SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.03336416
141STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.02941424
142TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.02612180
143CTCF_18555785_ChIP-Seq_MESCs_Mouse1.02606128
144SA1_27219007_Chip-Seq_Bcells_Human1.02196075
145RUNX2_22187159_ChIP-Seq_PCA_Human1.02036971
146MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.01297027
147NR3C1_21868756_ChIP-Seq_MCF10A_Human1.01193719
148JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.00976022
149ELF1_20517297_ChIP-Seq_JURKAT_Human1.00106781
150RUNX1_27514584_Chip-Seq_MCF-7_Human0.99701439
151SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.99017344
152SMAD3_21741376_ChIP-Seq_ESCs_Human0.98993495
153TP53_18474530_ChIP-ChIP_U2OS_Human0.98396622
154NANOG_18555785_Chip-Seq_ESCs_Mouse0.97459359
155STAT6_21828071_ChIP-Seq_BEAS2B_Human0.96937131
156PRDM14_20953172_ChIP-Seq_ESCs_Human0.95333744
157MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95252968
158SMAD4_21741376_ChIP-Seq_HESCs_Human0.94748272
159OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.94623123
160TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.94273744
161ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.91337277
162FUS_26573619_Chip-Seq_HEK293_Human0.90241005
163TP53_20018659_ChIP-ChIP_R1E_Mouse0.89355093
164LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86708815
165TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.86128420
166STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.85559955
167EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.85516585

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis4.30350529
2MP0004859_abnormal_synaptic_plasticity4.23976711
3MP0003880_abnormal_central_pattern3.80599478
4MP0001968_abnormal_touch/_nociception3.51364834
5MP0002735_abnormal_chemical_nociception3.49436856
6MP0004270_analgesia3.45604095
7MP0005423_abnormal_somatic_nervous3.18764334
8MP0003635_abnormal_synaptic_transmissio3.15970741
9MP0002734_abnormal_mechanical_nocicepti3.10363458
10MP0002736_abnormal_nociception_after3.08360745
11MP0006276_abnormal_autonomic_nervous2.72273978
12MP0002733_abnormal_thermal_nociception2.63335958
13MP0009745_abnormal_behavioral_response2.58708479
14MP0002139_abnormal_hepatobiliary_system2.52438659
15MP0009046_muscle_twitch2.50925156
16MP0002064_seizures2.49541847
17MP0002063_abnormal_learning/memory/cond2.47411479
18MP0010030_abnormal_orbit_morphology2.44626805
19MP0000778_abnormal_nervous_system2.44563653
20MP0001970_abnormal_pain_threshold2.43746309
21MP0001486_abnormal_startle_reflex2.43406741
22MP0002272_abnormal_nervous_system2.41479185
23MP0003123_paternal_imprinting2.35745327
24MP0002572_abnormal_emotion/affect_behav2.34797893
25MP0004858_abnormal_nervous_system2.34693747
26MP0002249_abnormal_larynx_morphology2.33234599
27MP0005365_abnormal_bile_salt2.30728515
28MP0009384_cardiac_valve_regurgitation2.29951778
29MP0002184_abnormal_innervation2.25787047
30MP0003705_abnormal_hypodermis_morpholog2.25148561
31MP0001440_abnormal_grooming_behavior2.08727502
32MP0002067_abnormal_sensory_capabilities2.07684725
33MP0008875_abnormal_xenobiotic_pharmacok1.91921802
34MP0005085_abnormal_gallbladder_physiolo1.85089179
35MP0000955_abnormal_spinal_cord1.77670866
36MP0000678_abnormal_parathyroid_gland1.77252284
37MP0002557_abnormal_social/conspecific_i1.74677361
38MP0005645_abnormal_hypothalamus_physiol1.71332190
39MP0002089_abnormal_postnatal_growth/wei1.70255405
40MP0001666_abnormal_nutrient_absorption1.67362459
41MP0005386_behavior/neurological_phenoty1.62207999
42MP0004924_abnormal_behavior1.62207999
43MP0004742_abnormal_vestibular_system1.60038688
44MP0010329_abnormal_lipoprotein_level1.59619910
45MP0004811_abnormal_neuron_physiology1.59028726
46MP0004885_abnormal_endolymph1.58617824
47MP0003122_maternal_imprinting1.57428254
48MP0001501_abnormal_sleep_pattern1.57239005
49MP0002882_abnormal_neuron_morphology1.55752789
50MP0004133_heterotaxia1.53322400
51MP0009840_abnormal_foam_cell1.52764591
52MP0001188_hyperpigmentation1.49857193
53MP0005257_abnormal_intraocular_pressure1.48103673
54MP0003136_yellow_coat_color1.43429962
55MP0008569_lethality_at_weaning1.42281636
56MP0001905_abnormal_dopamine_level1.40852128
57MP0001849_ear_inflammation1.38795234
58MP0005646_abnormal_pituitary_gland1.36547083
59MP0005058_abnormal_lysosome_morphology1.35569157
60MP0010386_abnormal_urinary_bladder1.33222254
61MP0002066_abnormal_motor_capabilities/c1.33195392
62MP0000569_abnormal_digit_pigmentation1.30683192
63MP0004142_abnormal_muscle_tone1.29832064
64MP0002751_abnormal_autonomic_nervous1.29296720
65MP0000920_abnormal_myelination1.28353551
66MP0002638_abnormal_pupillary_reflex1.27976212
67MP0005451_abnormal_body_composition1.25429216
68MP0003315_abnormal_perineum_morphology1.25235540
69MP0001984_abnormal_olfaction1.24112563
70MP0002822_catalepsy1.23878065
71MP0003634_abnormal_glial_cell1.23101642
72MP0003787_abnormal_imprinting1.19951235
73MP0003329_amyloid_beta_deposits1.19273976
74MP0001986_abnormal_taste_sensitivity1.19205750
75MP0001529_abnormal_vocalization1.19163817
76MP0001299_abnormal_eye_distance/1.18300160
77MP0009780_abnormal_chondrocyte_physiolo1.14973852
78MP0002752_abnormal_somatic_nervous1.14903372
79MP0004019_abnormal_vitamin_homeostasis1.14804002
80MP0002152_abnormal_brain_morphology1.13855940
81MP0000681_abnormal_thyroid_gland1.12507255
82MP0001502_abnormal_circadian_rhythm1.12359325
83MP0004264_abnormal_extraembryonic_tissu1.12141492
84MP0000049_abnormal_middle_ear1.10841146
85MP0002653_abnormal_ependyma_morphology1.09565205
86MP0002229_neurodegeneration1.06510267
87MP0008260_abnormal_autophagy1.04947366
88MP0002234_abnormal_pharynx_morphology1.02746693
89MP0005551_abnormal_eye_electrophysiolog1.02703541
90MP0006292_abnormal_olfactory_placode1.02054659
91MP0000631_abnormal_neuroendocrine_gland1.00548485
92MP0001963_abnormal_hearing_physiology1.00292166
93MP0005409_darkened_coat_color0.99815915
94MP0004272_abnormal_basement_membrane0.99434896
95MP0000534_abnormal_ureter_morphology0.97406112
96MP0005377_hearing/vestibular/ear_phenot0.97304989
97MP0003878_abnormal_ear_physiology0.97304989
98MP0000003_abnormal_adipose_tissue0.97283364
99MP0002876_abnormal_thyroid_physiology0.96736496
100MP0003938_abnormal_ear_development0.95066340
101MP0000751_myopathy0.94148401
102MP0003121_genomic_imprinting0.92608180
103MP0005171_absent_coat_pigmentation0.91961307
104MP0008789_abnormal_olfactory_epithelium0.91922801
105MP0002254_reproductive_system_inflammat0.91865069
106MP0000604_amyloidosis0.91504422
107MP0001348_abnormal_lacrimal_gland0.90430382
108MP0005332_abnormal_amino_acid0.89463089
109MP0003172_abnormal_lysosome_physiology0.88504898
110MP0001485_abnormal_pinna_reflex0.88450488
111MP0009053_abnormal_anal_canal0.88350572
112MP0002909_abnormal_adrenal_gland0.87481708
113MP0003631_nervous_system_phenotype0.86099623
114MP0006072_abnormal_retinal_apoptosis0.85828819
115MP0000026_abnormal_inner_ear0.85173619
116MP0003283_abnormal_digestive_organ0.84730018
117MP0003633_abnormal_nervous_system0.83948699
118MP0003183_abnormal_peptide_metabolism0.83713159
119MP0002932_abnormal_joint_morphology0.82945426
120MP0003861_abnormal_nervous_system0.82699061
121MP0003632_abnormal_nervous_system0.82559834
122MP0005670_abnormal_white_adipose0.81460372
123MP0001664_abnormal_digestion0.80457071
124MP0002102_abnormal_ear_morphology0.80058079
125MP0000538_abnormal_urinary_bladder0.79826770
126MP0003879_abnormal_hair_cell0.79404487
127MP0005623_abnormal_meninges_morphology0.79158774
128MP0003119_abnormal_digestive_system0.78949134
129MP0002069_abnormal_eating/drinking_beha0.78334524
130MP0005083_abnormal_biliary_tract0.76129444
131MP0003045_fibrosis0.75665957
132MP0002118_abnormal_lipid_homeostasis0.75575357
133MP0004145_abnormal_muscle_electrophysio0.75386635
134MP0002116_abnormal_craniofacial_bone0.74800016
135MP0004085_abnormal_heartbeat0.74564811
136MP0000467_abnormal_esophagus_morphology0.73021735
137MP0002233_abnormal_nose_morphology0.72928926
138MP0005076_abnormal_cell_differentiation0.72471729
139MP0002282_abnormal_trachea_morphology0.72419278
140MP0005394_taste/olfaction_phenotype0.70345930
141MP0005499_abnormal_olfactory_system0.70345930
142MP0005503_abnormal_tendon_morphology0.70286811
143MP0003115_abnormal_respiratory_system0.69451337
144MP0001177_atelectasis0.68851796
145MP0000566_synostosis0.68009405
146MP0001943_abnormal_respiration0.67696703
147MP0002092_abnormal_eye_morphology0.67522981
148MP0001764_abnormal_homeostasis0.67228091
149MP0005253_abnormal_eye_physiology0.65668401
150MP0000579_abnormal_nail_morphology0.64479395
151MP0003942_abnormal_urinary_system0.64055613
152MP0003385_abnormal_body_wall0.63292611
153MP0002090_abnormal_vision0.62880905
154MP0003690_abnormal_glial_cell0.62457283
155MP0000462_abnormal_digestive_system0.59498003
156MP0003137_abnormal_impulse_conducting0.59422806
157MP0000537_abnormal_urethra_morphology0.58897081
158MP0001346_abnormal_lacrimal_gland0.56798028
159MP0009379_abnormal_foot_pigmentation0.55853031

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)5.85439270
2Focal motor seizures (HP:0011153)4.89537902
3Deep venous thrombosis (HP:0002625)4.69248195
4Abnormality of the aortic arch (HP:0012303)4.56922366
5Focal seizures (HP:0007359)4.34521257
6Febrile seizures (HP:0002373)4.13397633
7Action tremor (HP:0002345)3.99294308
8Atonic seizures (HP:0010819)3.98201125
9Supranuclear gaze palsy (HP:0000605)3.96254789
10Progressive cerebellar ataxia (HP:0002073)3.90392637
11Limb dystonia (HP:0002451)3.75010519
12Ulnar claw (HP:0001178)3.69928313
13Epileptic encephalopathy (HP:0200134)3.55215129
14Ankle clonus (HP:0011448)3.49461454
15Insidious onset (HP:0003587)3.45111367
16Termporal pattern (HP:0011008)3.45111367
17Turricephaly (HP:0000262)3.35169561
18Abnormality of the corticospinal tract (HP:0002492)3.22723892
19Visual hallucinations (HP:0002367)3.13373314
20Bronchomalacia (HP:0002780)3.06667111
21Akinesia (HP:0002304)3.06320061
22Lymphangioma (HP:0100764)3.06154483
23Complement deficiency (HP:0004431)2.99032549
24Absence seizures (HP:0002121)2.93790512
25Xanthomatosis (HP:0000991)2.90810254
26Abnormality of glutamine family amino acid metabolism (HP:0010902)2.87653863
27Pheochromocytoma (HP:0002666)2.84577136
28Thin bony cortex (HP:0002753)2.84025786
29Amblyopia (HP:0000646)2.83883831
30Generalized tonic-clonic seizures (HP:0002069)2.83613784
31Abnormality of monocarboxylic acid metabolism (HP:0010996)2.76386307
32Broad-based gait (HP:0002136)2.75596258
33Dialeptic seizures (HP:0011146)2.72953251
34Spastic gait (HP:0002064)2.66736014
35Broad metatarsal (HP:0001783)2.66166498
36Progressive inability to walk (HP:0002505)2.65406905
37Exotropia (HP:0000577)2.64644167
38Stridor (HP:0010307)2.58060927
39Hypoventilation (HP:0002791)2.56439319
40Systemic lupus erythematosus (HP:0002725)2.55863276
41Failure to thrive in infancy (HP:0001531)2.54238002
42Degeneration of the lateral corticospinal tracts (HP:0002314)2.53884121
43Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.53884121
44Aplasia/Hypoplasia of the brainstem (HP:0007362)2.53652171
45Hypoplasia of the brainstem (HP:0002365)2.53652171
46Cervical subluxation (HP:0003308)2.52837675
47Urinary urgency (HP:0000012)2.52664221
48Sensory axonal neuropathy (HP:0003390)2.51081598
49Hyperglycinuria (HP:0003108)2.47286703
50Mutism (HP:0002300)2.46746215
51Truncal ataxia (HP:0002078)2.46065151
52Hydroxyprolinuria (HP:0003080)2.44485625
53Abnormality of proline metabolism (HP:0010907)2.44485625
54Hypothermia (HP:0002045)2.43504181
55Partial duplication of thumb phalanx (HP:0009944)2.41485065
56Abnormal eating behavior (HP:0100738)2.41400872
57Abnormality of complement system (HP:0005339)2.41362444
58Atrophic scars (HP:0001075)2.40663779
59Obstructive sleep apnea (HP:0002870)2.40320041
60Megalencephaly (HP:0001355)2.39526312
61Vitreoretinal degeneration (HP:0000655)2.38269146
62Dysmetria (HP:0001310)2.38026709
63Prolonged partial thromboplastin time (HP:0003645)2.33781142
64Peripheral hypomyelination (HP:0007182)2.32953897
65Abnormality of aromatic amino acid family metabolism (HP:0004338)2.32852343
66Agitation (HP:0000713)2.31873566
67Urinary bladder sphincter dysfunction (HP:0002839)2.31451841
68Hemorrhage of the eye (HP:0011885)2.30240497
69Neurofibrillary tangles (HP:0002185)2.28384671
70Gaze-evoked nystagmus (HP:0000640)2.27945269
71Torticollis (HP:0000473)2.26908365
72Fetal akinesia sequence (HP:0001989)2.25587744
73Joint hemorrhage (HP:0005261)2.24803186
74Polyphagia (HP:0002591)2.23663503
75Neuroendocrine neoplasm (HP:0100634)2.23500897
76Postural tremor (HP:0002174)2.21407127
77Abnormality of glycine metabolism (HP:0010895)2.21064071
78Abnormality of serine family amino acid metabolism (HP:0010894)2.21064071
79Excessive salivation (HP:0003781)2.20748321
80Drooling (HP:0002307)2.20748321
81Distal upper limb amyotrophy (HP:0007149)2.19405455
82Upper limb amyotrophy (HP:0009129)2.19405455
83Cerebral palsy (HP:0100021)2.18570733
84Aplasia involving bones of the upper limbs (HP:0009823)2.17546192
85Aplasia of the phalanges of the hand (HP:0009802)2.17546192
86Aplasia involving bones of the extremities (HP:0009825)2.17546192
87Shallow orbits (HP:0000586)2.16567650
88Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.13596278
89Fragile skin (HP:0001030)2.13507637
90Intention tremor (HP:0002080)2.13204046
91Partial duplication of the phalanx of hand (HP:0009999)2.11728335
92Decreased number of peripheral myelinated nerve fibers (HP:0003380)2.11429714
93Steppage gait (HP:0003376)2.11168712
94Glomerulonephritis (HP:0000099)2.10192260
95Lower limb muscle weakness (HP:0007340)2.07086764
96Bifid scrotum (HP:0000048)2.06635770
97Nuclear cataract (HP:0100018)2.05685529
98Congenital malformation of the right heart (HP:0011723)2.05319306
99Double outlet right ventricle (HP:0001719)2.05319306
100Scanning speech (HP:0002168)2.04777430
101Onion bulb formation (HP:0003383)2.02087363
102Anxiety (HP:0000739)2.02032859
103Hyperacusis (HP:0010780)2.00020309
104Short femoral neck (HP:0100864)1.99907943
105Segmental peripheral demyelination/remyelination (HP:0003481)1.99385419
106Rib fusion (HP:0000902)1.99008524
107Hand muscle atrophy (HP:0009130)1.97253707
108Depression (HP:0000716)1.96517143
109Truncus arteriosus (HP:0001660)1.94760065
110Abnormality of the Achilles tendon (HP:0005109)1.93002624
111Esotropia (HP:0000565)1.92316717
112Choanal stenosis (HP:0000452)1.91929627
113Neonatal short-limb short stature (HP:0008921)1.91176771
114J-shaped sella turcica (HP:0002680)1.90869367
115Hammertoe (HP:0001765)1.90370875
116Hemiparesis (HP:0001269)1.90251671
117Coronal craniosynostosis (HP:0004440)1.89309512
118Impaired vibration sensation in the lower limbs (HP:0002166)1.88772069
119Narrow nasal bridge (HP:0000446)1.88685276
120Delayed epiphyseal ossification (HP:0002663)1.88342360
121Flat acetabular roof (HP:0003180)1.88329897
122Sleep apnea (HP:0010535)1.88278135
123Abnormality of carpal bone ossification (HP:0006257)1.85746274
124Poor eye contact (HP:0000817)1.85486762
125Blue irides (HP:0000635)1.85220314
126Epiphyseal dysplasia (HP:0002656)1.84910214
127Zonular cataract (HP:0010920)1.84706989
128Biconcave vertebral bodies (HP:0004586)1.83354127
129Focal dystonia (HP:0004373)1.82525495
130Shawl scrotum (HP:0000049)1.82413157
131Gait imbalance (HP:0002141)1.81510647
132Cerebral inclusion bodies (HP:0100314)1.81215464
133Craniofacial dystonia (HP:0012179)1.81029427
134Dysdiadochokinesis (HP:0002075)1.80907804
135Abnormality of calcium-phosphate metabolism (HP:0100530)1.80625644
136Retinal atrophy (HP:0001105)1.80216970
137Abnormal social behavior (HP:0012433)1.80108575
138Impaired social interactions (HP:0000735)1.80108575
139Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.80082212
140Retinal dysplasia (HP:0007973)1.79894165
141Hyperventilation (HP:0002883)1.79808781
142Morphological abnormality of the middle ear (HP:0008609)1.79434907
143Decreased motor nerve conduction velocity (HP:0003431)1.77949003
144Protrusio acetabuli (HP:0003179)1.77864176
145Lissencephaly (HP:0001339)1.77295755
146Abnormality of the ischium (HP:0003174)1.76722132
147Morphological abnormality of the pyramidal tract (HP:0002062)1.76307078
148Myotonia (HP:0002486)1.75707673
149Specific learning disability (HP:0001328)1.75616803
150Hyperthyroidism (HP:0000836)1.75375113
151Papilledema (HP:0001085)1.74651644
152Esophageal atresia (HP:0002032)1.74637470
153Long toe (HP:0010511)1.73959283
154Abnormal hair whorl (HP:0010721)1.73636872
155Flat capital femoral epiphysis (HP:0003370)1.72762979
156Inability to walk (HP:0002540)1.72585919
157Infantile muscular hypotonia (HP:0008947)1.72012071
158EEG with generalized epileptiform discharges (HP:0011198)1.71280772
159Genital tract atresia (HP:0001827)1.71275698
160Abnormality of the lower motor neuron (HP:0002366)1.70487853
161Abnormal tarsal ossification (HP:0008369)1.70244081
162Cerebral aneurysm (HP:0004944)1.69952104
163Epileptiform EEG discharges (HP:0011182)1.69667504
164Abnormality of the parathyroid morphology (HP:0011766)1.69406791
165Achilles tendon contracture (HP:0001771)1.69371753
166Postural instability (HP:0002172)1.68751259
167Ulnar bowing (HP:0003031)1.68059267
168Pterygium (HP:0001059)1.67503458
169Abnormality of the vitreous humor (HP:0004327)1.66029590
170Abnormality of the thoracic spine (HP:0100711)1.65984474
171Premature skin wrinkling (HP:0100678)1.65600680
172Hypsarrhythmia (HP:0002521)1.65450635
173Growth hormone excess (HP:0000845)1.63699436
174Neonatal onset (HP:0003623)1.63373051
175Delayed CNS myelination (HP:0002188)1.63070870
176Intrahepatic cholestasis (HP:0001406)1.63007296
177Hypoalphalipoproteinemia (HP:0003233)1.62340234
178Aplasia/hypoplasia of the femur (HP:0005613)1.61909300
179Aplasia/Hypoplasia involving the pelvis (HP:0009103)1.60945290
180Renal duplication (HP:0000075)1.60198021
181Hyperglycinemia (HP:0002154)1.59793787
182Disproportionate tall stature (HP:0001519)1.59014220
183Hypercholesterolemia (HP:0003124)1.57384516
184Urinary glycosaminoglycan excretion (HP:0003541)1.57278023
185Mucopolysacchariduria (HP:0008155)1.57278023
186Nephrolithiasis (HP:0000787)1.57224634
187Rectal prolapse (HP:0002035)1.56491188
188Protuberant abdomen (HP:0001538)1.54681330
189Abnormal connection of the cardiac segments (HP:0011545)1.54448277

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.55412129
2TRIB33.99635909
3NTRK33.59082337
4TAOK23.38878297
5RIPK13.07365607
6PRKD33.01444380
7CASK2.89749119
8MAP3K42.64903240
9MAP3K92.51055652
10NTRK22.47284807
11ICK2.44381753
12MAPK132.40050239
13MINK12.39736788
14MAP2K62.36018572
15PKN22.35637249
16STK392.32455553
17FGFR42.29391860
18MAP2K72.25350241
19EPHA22.18085122
20SMG11.96298831
21NTRK11.92988837
22EEF2K1.90074860
23TNIK1.89241538
24PAK61.86374286
25LMTK21.84578222
26PNCK1.83100236
27PHKG21.77838550
28PHKG11.77838550
29ERN11.76876221
30MAP3K111.76048304
31GRK51.76024114
32CAMK1D1.60080218
33UHMK11.56343756
34MAP3K121.52091299
35OXSR11.52022423
36SIK21.51525855
37WNK11.46609057
38MST1R1.42169235
39AKT31.36186966
40CDK51.36056789
41LIMK11.35081156
42PRKD21.34157887
43MAPK151.32896496
44DAPK21.32439840
45WNK41.32120900
46PRPF4B1.32055048
47LATS21.31425584
48DYRK21.30423133
49MAP2K41.22952856
50SGK2231.22616933
51SGK4941.22616933
52NME21.21678192
53PTK21.20780098
54MAP3K21.20641714
55CAMK1G1.19518200
56CSNK1G21.19492397
57CDK191.15759122
58GRK71.13193169
59RET1.13064349
60PLK21.09609407
61BMPR1B1.06248448
62NME11.05345111
63EPHA41.04948016
64CSNK1G30.99773270
65WNK30.97684409
66BCR0.96426544
67CSNK1A1L0.96309537
68KSR20.95099526
69PDGFRA0.94944881
70SIK30.92827598
71DYRK1B0.91998404
72MATK0.89893697
73MET0.89832887
74PTK60.89397544
75FGFR20.88813222
76PKN10.88178798
77PAK30.86826717
78SGK20.84308414
79EPHB20.81956444
80CDK140.81584508
81CAMK2A0.81416693
82ERBB30.81217685
83KSR10.79106633
84MAP3K60.79014534
85PRKCI0.78752681
86RPS6KA20.77857054
87MTOR0.77807341
88MAPKAPK50.77055995
89EPHB10.76578290
90MARK20.76476159
91BCKDK0.76249857
92TESK10.75224130
93CDK180.75057360
94ADRBK10.74959973
95TAOK10.73872628
96PRKCG0.73242379
97CDK150.73029845
98TLK10.72929313
99DYRK1A0.72471336
100PRKCE0.72243367
101DMPK0.72038557
102CSNK1G10.71588917
103STK160.70808902
104IRAK30.70672751
105TNK20.68825520
106DDR20.68062929
107CAMKK10.67833711
108CAMK2B0.67690670
109ROCK20.65065408
110STK110.64791084
111CDK11A0.63985659
112SGK30.63594892
113PIM20.62602523
114NEK60.61113952
115IRAK20.60358981
116FER0.59784455
117MAP3K70.59758975
118FGR0.59320227
119ROCK10.58386136
120TYRO30.58267108
121SIK10.57536962
122ILK0.57054226
123FYN0.56179493
124ADRBK20.54923943
125RPS6KC10.53598977
126RPS6KL10.53598977
127CAMK10.53513471
128CDC42BPA0.52893796
129STK380.52576558
130BMX0.52207542
131PRKAA10.51528848
132CAMKK20.51392846
133PRKCH0.50151961
134SGK10.45535004
135PDPK10.45533888
136PRKG20.45451889
137ARAF0.43754592
138MAPK80.43420242
139RPS6KA60.42792257
140PRKCZ0.41118031
141DAPK30.40810925
142PRKAA20.40448036
143CAMK2G0.40260641
144CSNK1A10.38099596
145PRKD10.37951453
146ERBB20.37488915
147CHUK0.37397020
148PRKG10.37252515
149PIK3CA0.37045082
150PTK2B0.35326956
151MAPK120.35165343
152CAMK2D0.34870880
153HIPK20.33797573
154MAPK40.33505834
155DAPK10.31571042
156MAPKAPK30.31344297
157AURKA0.27791945

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004603.86496644
2Nicotine addiction_Homo sapiens_hsa050333.22280705
3Synaptic vesicle cycle_Homo sapiens_hsa047212.92207646
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.23026721
5GABAergic synapse_Homo sapiens_hsa047272.18917404
6Glutamatergic synapse_Homo sapiens_hsa047242.13081827
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.08368604
8Glycosaminoglycan degradation_Homo sapiens_hsa005312.06275589
9Olfactory transduction_Homo sapiens_hsa047402.05315937
10Circadian entrainment_Homo sapiens_hsa047132.03770590
11Complement and coagulation cascades_Homo sapiens_hsa046102.01207157
12Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.01127712
13Morphine addiction_Homo sapiens_hsa050322.00235272
14Fat digestion and absorption_Homo sapiens_hsa049751.93759959
15Axon guidance_Homo sapiens_hsa043601.91805207
16Taste transduction_Homo sapiens_hsa047421.91580999
17Arginine biosynthesis_Homo sapiens_hsa002201.87687494
182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.87195616
19Dopaminergic synapse_Homo sapiens_hsa047281.86342213
20Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.82856069
21Phenylalanine metabolism_Homo sapiens_hsa003601.82755258
22Histidine metabolism_Homo sapiens_hsa003401.81338361
23Sulfur relay system_Homo sapiens_hsa041221.80475460
24Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.76508660
25Serotonergic synapse_Homo sapiens_hsa047261.72927539
26Long-term potentiation_Homo sapiens_hsa047201.72635119
27Cholinergic synapse_Homo sapiens_hsa047251.69332947
28Arginine and proline metabolism_Homo sapiens_hsa003301.67334306
29Amphetamine addiction_Homo sapiens_hsa050311.66532923
30Salivary secretion_Homo sapiens_hsa049701.66367672
31Notch signaling pathway_Homo sapiens_hsa043301.63508825
32Bile secretion_Homo sapiens_hsa049761.63277561
33Insulin secretion_Homo sapiens_hsa049111.61830093
34PPAR signaling pathway_Homo sapiens_hsa033201.60108537
35Cocaine addiction_Homo sapiens_hsa050301.56998838
36Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.54164923
37Long-term depression_Homo sapiens_hsa047301.52909464
38Other glycan degradation_Homo sapiens_hsa005111.51933283
39Fatty acid degradation_Homo sapiens_hsa000711.49588581
40Gastric acid secretion_Homo sapiens_hsa049711.48270051
41Collecting duct acid secretion_Homo sapiens_hsa049661.47799483
42Primary bile acid biosynthesis_Homo sapiens_hsa001201.46865401
43Retinol metabolism_Homo sapiens_hsa008301.45599531
44Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.44723487
45Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.44231569
46Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.41779720
47Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.41535809
48Tyrosine metabolism_Homo sapiens_hsa003501.40882134
49Renin secretion_Homo sapiens_hsa049241.36177131
50Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.36128855
51Caffeine metabolism_Homo sapiens_hsa002321.34101740
52Fatty acid metabolism_Homo sapiens_hsa012121.33241451
53Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.33158492
54Galactose metabolism_Homo sapiens_hsa000521.29723885
55ErbB signaling pathway_Homo sapiens_hsa040121.25141358
56Aldosterone synthesis and secretion_Homo sapiens_hsa049251.22162253
57Gap junction_Homo sapiens_hsa045401.21991170
58Oxytocin signaling pathway_Homo sapiens_hsa049211.21581987
59Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.21132550
60Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.20602844
61Chemical carcinogenesis_Homo sapiens_hsa052041.20443624
62Vibrio cholerae infection_Homo sapiens_hsa051101.18775004
63Pentose and glucuronate interconversions_Homo sapiens_hsa000401.18447782
64Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.18134239
65Calcium signaling pathway_Homo sapiens_hsa040201.16914126
66Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.16674597
67Fructose and mannose metabolism_Homo sapiens_hsa000511.14361764
68Vitamin digestion and absorption_Homo sapiens_hsa049771.14134474
69GnRH signaling pathway_Homo sapiens_hsa049121.13687587
70Cardiac muscle contraction_Homo sapiens_hsa042601.11443232
71Biosynthesis of amino acids_Homo sapiens_hsa012301.08799676
72Dorso-ventral axis formation_Homo sapiens_hsa043201.06831498
73Steroid hormone biosynthesis_Homo sapiens_hsa001401.04995736
74Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.04389488
75Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.02626433
76Fatty acid biosynthesis_Homo sapiens_hsa000611.01726495
77Type II diabetes mellitus_Homo sapiens_hsa049301.01508284
78cAMP signaling pathway_Homo sapiens_hsa040241.01195297
79Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.00973647
80Estrogen signaling pathway_Homo sapiens_hsa049150.98621369
81Melanogenesis_Homo sapiens_hsa049160.98327844
82Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.98163887
83Phosphatidylinositol signaling system_Homo sapiens_hsa040700.97819656
84Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.97442840
85Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.95448897
86ABC transporters_Homo sapiens_hsa020100.95299387
87Phototransduction_Homo sapiens_hsa047440.94529642
88Renin-angiotensin system_Homo sapiens_hsa046140.91156517
89Pyruvate metabolism_Homo sapiens_hsa006200.90946028
90Pancreatic secretion_Homo sapiens_hsa049720.90879221
91Starch and sucrose metabolism_Homo sapiens_hsa005000.90545083
92Glioma_Homo sapiens_hsa052140.90434835
93Drug metabolism - other enzymes_Homo sapiens_hsa009830.89550215
94alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.89463434
95Linoleic acid metabolism_Homo sapiens_hsa005910.88944344
96Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.88509299
97Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.88180021
98Endometrial cancer_Homo sapiens_hsa052130.87047229
99Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.84580229
100Prion diseases_Homo sapiens_hsa050200.84075510
101Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.83970659
102Peroxisome_Homo sapiens_hsa041460.83869242
103Vitamin B6 metabolism_Homo sapiens_hsa007500.83228725
104Vascular smooth muscle contraction_Homo sapiens_hsa042700.81826752
105Phospholipase D signaling pathway_Homo sapiens_hsa040720.81613411
106Glycerolipid metabolism_Homo sapiens_hsa005610.80791883
107Oxidative phosphorylation_Homo sapiens_hsa001900.80411272
108cGMP-PKG signaling pathway_Homo sapiens_hsa040220.79849412
109Renal cell carcinoma_Homo sapiens_hsa052110.75552800
110Ras signaling pathway_Homo sapiens_hsa040140.75112328
111Alzheimers disease_Homo sapiens_hsa050100.74944157
112MAPK signaling pathway_Homo sapiens_hsa040100.73089538
113SNARE interactions in vesicular transport_Homo sapiens_hsa041300.71818918
114Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.71486136
115Hedgehog signaling pathway_Homo sapiens_hsa043400.70688082
116AMPK signaling pathway_Homo sapiens_hsa041520.70270692
117Wnt signaling pathway_Homo sapiens_hsa043100.70256847
118Choline metabolism in cancer_Homo sapiens_hsa052310.69622137
119Dilated cardiomyopathy_Homo sapiens_hsa054140.68577883
120Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.67739067
121Neurotrophin signaling pathway_Homo sapiens_hsa047220.67085220
122Sphingolipid signaling pathway_Homo sapiens_hsa040710.67071298
123Arachidonic acid metabolism_Homo sapiens_hsa005900.66614454
124Endocytosis_Homo sapiens_hsa041440.65890072
125Tryptophan metabolism_Homo sapiens_hsa003800.65150624
126beta-Alanine metabolism_Homo sapiens_hsa004100.64981852
127ECM-receptor interaction_Homo sapiens_hsa045120.64975588
128Butanoate metabolism_Homo sapiens_hsa006500.63975705
129Parkinsons disease_Homo sapiens_hsa050120.63264025
130Lysine degradation_Homo sapiens_hsa003100.63021023
131Rap1 signaling pathway_Homo sapiens_hsa040150.61326937
132Phagosome_Homo sapiens_hsa041450.60745578
133Melanoma_Homo sapiens_hsa052180.59756449
134Carbohydrate digestion and absorption_Homo sapiens_hsa049730.59710195
135Carbon metabolism_Homo sapiens_hsa012000.59202626
136Glucagon signaling pathway_Homo sapiens_hsa049220.58461251
137Sphingolipid metabolism_Homo sapiens_hsa006000.58168177
138Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.57183684
139Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.56792449
140Prolactin signaling pathway_Homo sapiens_hsa049170.56139298
141Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.56077490
142Thyroid hormone synthesis_Homo sapiens_hsa049180.55979237
143Glycerophospholipid metabolism_Homo sapiens_hsa005640.53180071
144Colorectal cancer_Homo sapiens_hsa052100.51426718
145Ether lipid metabolism_Homo sapiens_hsa005650.51063639
146Tight junction_Homo sapiens_hsa045300.50858355
147Sulfur metabolism_Homo sapiens_hsa009200.50403045
148VEGF signaling pathway_Homo sapiens_hsa043700.48869232
149Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.48743304
150Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.48730669
151Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.48454861
152Steroid biosynthesis_Homo sapiens_hsa001000.48192946
153Inositol phosphate metabolism_Homo sapiens_hsa005620.47966436
154Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.47360550
155Rheumatoid arthritis_Homo sapiens_hsa053230.46799112
156Insulin signaling pathway_Homo sapiens_hsa049100.44548446
157Protein digestion and absorption_Homo sapiens_hsa049740.44302760
158Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.43906185
159Glutathione metabolism_Homo sapiens_hsa004800.43794422
160Hippo signaling pathway_Homo sapiens_hsa043900.43200539
161Mineral absorption_Homo sapiens_hsa049780.42579565
162Alcoholism_Homo sapiens_hsa050340.40723913
163Maturity onset diabetes of the young_Homo sapiens_hsa049500.40586879
164Longevity regulating pathway - mammal_Homo sapiens_hsa042110.40414215
165Metabolic pathways_Homo sapiens_hsa011000.40031441
166Basal cell carcinoma_Homo sapiens_hsa052170.39622628
167Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.39090845
168Ovarian steroidogenesis_Homo sapiens_hsa049130.37130644
169Regulation of actin cytoskeleton_Homo sapiens_hsa048100.35571160

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