LRRC8C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.60870113
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.60870113
3positive regulation of gamma-delta T cell activation (GO:0046645)4.54684562
4antigen processing and presentation of endogenous antigen (GO:0019883)4.48725605
5negative T cell selection (GO:0043383)4.00207044
6negative thymic T cell selection (GO:0045060)3.96467482
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.87268098
8negative regulation of interleukin-12 production (GO:0032695)3.82584785
9modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.77453065
10positive regulation by organism of defense response of other organism involved in symbiotic interact3.77453065
11modulation by symbiont of host immune response (GO:0052553)3.77453065
12positive regulation by symbiont of host defense response (GO:0052509)3.77453065
13modulation by symbiont of host defense response (GO:0052031)3.77453065
14modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.77453065
15response to interleukin-15 (GO:0070672)3.75801954
16negative regulation of T cell mediated immunity (GO:0002710)3.71598090
17tolerance induction (GO:0002507)3.68685129
18cellular extravasation (GO:0045123)3.68477399
19regulation of interleukin-12 biosynthetic process (GO:0045075)3.67508513
20substrate-dependent cell migration (GO:0006929)3.66996675
21response to peptidoglycan (GO:0032494)3.56848469
22myeloid dendritic cell differentiation (GO:0043011)3.55645910
23positive regulation of natural killer cell differentiation (GO:0032825)3.50023559
24T cell migration (GO:0072678)3.49686630
25regulation of T cell tolerance induction (GO:0002664)3.48816537
26positive regulation of granulocyte differentiation (GO:0030854)3.46191791
27positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.39308987
28positive regulation of B cell differentiation (GO:0045579)3.38967907
29regulation of dendritic cell antigen processing and presentation (GO:0002604)3.37674624
30regulation of B cell differentiation (GO:0045577)3.36617084
31regulation of gamma-delta T cell differentiation (GO:0045586)3.35725408
32establishment of endothelial barrier (GO:0061028)3.34081265
33myeloid dendritic cell activation (GO:0001773)3.32254854
34positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.31496951
35macrophage activation involved in immune response (GO:0002281)3.29718244
36B cell receptor signaling pathway (GO:0050853)3.29479927
37response to muramyl dipeptide (GO:0032495)3.27324309
38regulation of T-helper 1 cell differentiation (GO:0045625)3.24686092
39cellular response to interleukin-15 (GO:0071350)3.22678143
40leukocyte aggregation (GO:0070486)3.21235562
41vascular endothelial growth factor signaling pathway (GO:0038084)3.19097453
42detection of other organism (GO:0098543)3.18743856
43NIK/NF-kappaB signaling (GO:0038061)3.17767722
44regulation of gamma-delta T cell activation (GO:0046643)3.17229866
45positive thymic T cell selection (GO:0045059)3.14250440
46myeloid cell activation involved in immune response (GO:0002275)3.13824999
47interferon-gamma production (GO:0032609)3.13551163
48negative regulation of lymphocyte mediated immunity (GO:0002707)3.12812436
49tyrosine phosphorylation of STAT protein (GO:0007260)3.12797218
50endothelial tube morphogenesis (GO:0061154)3.11585944
51morphogenesis of an endothelium (GO:0003159)3.11585944
52thymic T cell selection (GO:0045061)3.10784923
53activated T cell proliferation (GO:0050798)3.09621673
54mast cell activation (GO:0045576)3.07849881
55regulation of regulatory T cell differentiation (GO:0045589)3.05288472
56negative regulation of erythrocyte differentiation (GO:0045647)3.04561428
57T cell selection (GO:0045058)3.02673646
58immunoglobulin mediated immune response (GO:0016064)3.00641158
59detection of molecule of bacterial origin (GO:0032490)2.95217784
60detection of bacterium (GO:0016045)2.95074849
61negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.92144413
62negative regulation of cell killing (GO:0031342)2.92144413
63cell adhesion mediated by integrin (GO:0033627)2.91998758
64angiogenesis involved in wound healing (GO:0060055)2.91386833
65leukocyte degranulation (GO:0043299)2.91225237
66positive regulation of macrophage differentiation (GO:0045651)2.88531506
67leukocyte cell-cell adhesion (GO:0007159)2.88143447
68lymph vessel development (GO:0001945)2.87770614
69regulation of alpha-beta T cell proliferation (GO:0046640)2.86935144
70antigen processing and presentation via MHC class Ib (GO:0002475)2.86651069
71surfactant homeostasis (GO:0043129)2.86609617
72negative regulation of leukocyte mediated immunity (GO:0002704)2.86536470
73antigen receptor-mediated signaling pathway (GO:0050851)2.85981310
74detection of external biotic stimulus (GO:0098581)2.84703978
75positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.84031266
76response to type I interferon (GO:0034340)2.83939824
77lipopolysaccharide-mediated signaling pathway (GO:0031663)2.83828755
78positive regulation of interleukin-2 production (GO:0032743)2.82727771
79Arp2/3 complex-mediated actin nucleation (GO:0034314)2.81402062
80T cell costimulation (GO:0031295)2.78256162
81JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.78198058
82granulocyte activation (GO:0036230)2.77418775
83T cell homeostasis (GO:0043029)2.76217187
84positive regulation of isotype switching (GO:0045830)2.75702814
85type I interferon signaling pathway (GO:0060337)2.73914392
86cellular response to type I interferon (GO:0071357)2.73914392
87lymphocyte costimulation (GO:0031294)2.72018899
88natural killer cell differentiation (GO:0001779)2.71327321
89positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.69324489
90positive T cell selection (GO:0043368)2.69004346
91natural killer cell activation (GO:0030101)2.68788300
92dendritic cell differentiation (GO:0097028)2.68205943
93positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.67781066
94regulation of granulocyte differentiation (GO:0030852)2.67369054
95regulation of tolerance induction (GO:0002643)2.66460571
96interferon-gamma-mediated signaling pathway (GO:0060333)2.65035022
97negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.64446675
98negative regulation of T-helper cell differentiation (GO:0045623)2.64446675
99positive regulation of lamellipodium assembly (GO:0010592)2.63992818
100regulation of natural killer cell mediated immunity (GO:0002715)2.63477496
101regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.63477496
102regulation of alpha-beta T cell activation (GO:0046634)2.63155602
103regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.62240202
104regulation of interleukin-2 biosynthetic process (GO:0045076)2.61923172
105regulation of T cell mediated cytotoxicity (GO:0001914)2.61902136
106myeloid leukocyte activation (GO:0002274)2.60985349
107positive regulation of alpha-beta T cell proliferation (GO:0046641)2.60851801
108regulation of necroptotic process (GO:0060544)2.60645982
109heterotypic cell-cell adhesion (GO:0034113)2.59811955
110positive regulation of immunoglobulin mediated immune response (GO:0002891)2.59210604
111positive regulation of B cell mediated immunity (GO:0002714)2.59210604
112microglial cell activation (GO:0001774)2.58239653
113positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.58211691
114positive regulation of vasculogenesis (GO:2001214)2.57265667
115positive regulation of alpha-beta T cell activation (GO:0046635)2.56904285
116defense response to protozoan (GO:0042832)2.56538420
117positive regulation of natural killer cell mediated immunity (GO:0002717)2.55675567
118positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.55675567
119leukocyte tethering or rolling (GO:0050901)2.55587274
120lymph node development (GO:0048535)2.54612252
121regulation of T-helper cell differentiation (GO:0045622)2.54272706
122regulation of isotype switching to IgG isotypes (GO:0048302)2.50459135
123regulation of T-helper 1 type immune response (GO:0002825)2.50434765
124regulation of B cell receptor signaling pathway (GO:0050855)2.50373866
125regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.48800833
126sprouting angiogenesis (GO:0002040)2.48112300
127T cell proliferation (GO:0042098)2.47865818
128positive regulation of antigen processing and presentation (GO:0002579)2.46281351
129positive regulation of tolerance induction (GO:0002645)2.46060515
130membrane raft organization (GO:0031579)2.45954514
131lymphocyte homeostasis (GO:0002260)2.45815944
132growth hormone receptor signaling pathway (GO:0060396)2.44776361
133cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.44478534
134regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.40880687
135B cell homeostasis (GO:0001782)2.40729460
136regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.39518670
137positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.39198108
138neutrophil activation (GO:0042119)2.38417785
139regulation of type I interferon-mediated signaling pathway (GO:0060338)2.37931805
140neutrophil activation involved in immune response (GO:0002283)2.37747218
141T cell receptor signaling pathway (GO:0050852)2.36230045
142germinal center formation (GO:0002467)2.35398666
143negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.32964024
144embryonic hemopoiesis (GO:0035162)2.32954947

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse6.86618915
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.28832351
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.07874719
4IRF8_22096565_ChIP-ChIP_GC-B_Human4.07473441
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.71620607
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.64959223
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.22380946
8SMAD_19615063_ChIP-ChIP_OVARY_Human3.19951916
9* STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.19340824
10RUNX_20019798_ChIP-Seq_JUKART_Human3.01917545
11IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.99543632
12IRF8_21731497_ChIP-ChIP_J774_Mouse2.87277381
13MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.86810064
14* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.70811899
15RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.48938241
16TRIM28_21343339_ChIP-Seq_HEK293_Human2.46250819
17IRF8_27001747_Chip-Seq_BMDM_Mouse2.43581767
18MYB_21317192_ChIP-Seq_ERMYB_Mouse2.41672049
19* MYB_26560356_Chip-Seq_TH2_Human2.39681592
20SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.32665338
21FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.32659470
22NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.23439378
23MAF_26560356_Chip-Seq_TH1_Human2.21477897
24SCL_19346495_ChIP-Seq_HPC-7_Human2.19078747
25MYC_22102868_ChIP-Seq_BL_Human2.10498238
26GATA2_21666600_ChIP-Seq_HMVEC_Human2.03323271
27VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.95415107
28* MYB_26560356_Chip-Seq_TH1_Human1.89802709
29SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.84610279
30* VDR_24763502_ChIP-Seq_THP-1_Human1.82807792
31ELK3_25401928_ChIP-Seq_HUVEC_Human1.73748534
32SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.73582667
33TCF7_22412390_ChIP-Seq_EML_Mouse1.73018022
34STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.71431239
35KDM2B_26808549_Chip-Seq_SUP-B15_Human1.70273528
36VDR_21846776_ChIP-Seq_THP-1_Human1.69812119
37* SPI1_23127762_ChIP-Seq_K562_Human1.66822349
38UTX_26944678_Chip-Seq_JUKART_Human1.61551078
39E2F7_22180533_ChIP-Seq_HELA_Human1.59482670
40* VDR_24787735_ChIP-Seq_THP-1_Human1.57887961
41* KDM2B_26808549_Chip-Seq_DND41_Human1.52453627
42BRD4_27068464_Chip-Seq_AML-cells_Mouse1.51161649
43SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.50076853
44* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.49791298
45NOTCH1_21737748_ChIP-Seq_TLL_Human1.49415193
46Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.47744601
47NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.46260890
48TP63_17297297_ChIP-ChIP_HaCaT_Human1.45805038
49RUNX1_22412390_ChIP-Seq_EML_Mouse1.43509394
50BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.43328190
51KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.42044337
52GATA3_27048872_Chip-Seq_THYMUS_Human1.40441868
53RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.40187118
54WT1_19549856_ChIP-ChIP_CCG9911_Human1.38156981
55GATA1_22025678_ChIP-Seq_K562_Human1.37350511
56FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.32395749
57SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.32243396
58SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.32243396
59PU_27001747_Chip-Seq_BMDM_Mouse1.28695703
60SPI1_23547873_ChIP-Seq_NB4_Human1.28220666
61TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.28081268
62* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.27146889
63ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.26521636
64GATA2_22383799_ChIP-Seq_G1ME_Mouse1.24998876
65RARG_19884340_ChIP-ChIP_MEFs_Mouse1.20625794
66FOXO3_23340844_ChIP-Seq_DLD1_Human1.18968600
67GATA1_19941826_ChIP-Seq_K562_Human1.17142168
68CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.16053650
69* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.15956631
70* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.15542198
71RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.15227952
72TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.14823974
73* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.14131288
74NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.12338168
75BRD4_25478319_ChIP-Seq_HGPS_Human1.12203235
76* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.10756412
77EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.09629798
78* MAF_26560356_Chip-Seq_TH2_Human1.09404632
79E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.09189680
80* KDM2B_26808549_Chip-Seq_JURKAT_Human1.08461932
81CJUN_26792858_Chip-Seq_BT549_Human1.07240714
82ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.07094343
83THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.06577115
84* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.04111364
85CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.03990137
86GATA2_19941826_ChIP-Seq_K562_Human1.03868486
87PPAR_26484153_Chip-Seq_NCI-H1993_Human1.02763089
88FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.01408130
89HIF1A_21447827_ChIP-Seq_MCF-7_Human1.00777717
90SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99036314
91GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98035513
92CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.97408846
93GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.95740321
94* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.94493121
95TBX20_22328084_ChIP-Seq_HEART_Mouse0.94056757
96TBX20_22080862_ChIP-Seq_HEART_Mouse0.94056757
97* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.93935410
98PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93667335
99PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92367578
100* UBF1/2_26484160_Chip-Seq_HMECs_Human0.92262089
101CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92105098
102* GATA1_19941827_ChIP-Seq_MEL_Mouse0.92026895
103* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.91397273
104GATA3_26560356_Chip-Seq_TH2_Human0.91011952
105* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.90172353
106* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.90153810
107GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89184591
108SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.88269985
109JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.84436790
110ZNF217_24962896_ChIP-Seq_MCF-7_Human0.84363739
111GATA1_19941827_ChIP-Seq_MEL86_Mouse0.84188732
112EP300_21415370_ChIP-Seq_HL-1_Mouse0.83353383
113TP53_18474530_ChIP-ChIP_U2OS_Human0.83172338
114MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.82590862
115AR_21572438_ChIP-Seq_LNCaP_Human0.81061788
116* LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.79894233
117TFEB_21752829_ChIP-Seq_HELA_Human0.77371407
118ELF1_17652178_ChIP-ChIP_JURKAT_Human0.76417414
119* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.76106856
120STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.73051593
121VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.72973897
122* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.72446011
123* NCOR1_26117541_ChIP-Seq_K562_Human0.70991521
124TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.70362847
125CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.69927283
126* SMRT_27268052_Chip-Seq_Bcells_Human0.69638315

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000685_abnormal_immune_system3.06689317
2MP0004510_myositis2.94610655
3MP0001835_abnormal_antigen_presentation2.93700490
4MP0005671_abnormal_response_to2.88392017
5MP0010368_abnormal_lymphatic_system2.70148938
6MP0001790_abnormal_immune_system2.64242780
7MP0005387_immune_system_phenotype2.64242780
8MP0003303_peritoneal_inflammation2.64101902
9MP0003724_increased_susceptibility_to2.59207489
10MP0003300_gastrointestinal_ulcer2.48853547
11MP0001879_abnormal_lymphatic_vessel2.46418021
12MP0009785_altered_susceptibility_to2.39813475
13MP0003763_abnormal_thymus_physiology2.29335142
14MP0002166_altered_tumor_susceptibility2.26405832
15MP0001800_abnormal_humoral_immune2.21304717
16MP0002396_abnormal_hematopoietic_system2.18514770
17MP0010352_gastrointestinal_tract_polyps2.13975375
18MP0005000_abnormal_immune_tolerance2.11223456
19MP0002452_abnormal_antigen_presenting2.05563934
20MP0002006_tumorigenesis2.04617304
21MP0003436_decreased_susceptibility_to2.04022111
22MP0004808_abnormal_hematopoietic_stem2.01177850
23MP0002723_abnormal_immune_serum1.99110906
24MP0002420_abnormal_adaptive_immunity1.97080564
25MP0001819_abnormal_immune_cell1.96954876
26MP0002148_abnormal_hypersensitivity_rea1.96666578
27MP0004272_abnormal_basement_membrane1.95135669
28MP0009278_abnormal_bone_marrow1.94441570
29MP0005397_hematopoietic_system_phenotyp1.94207816
30MP0001545_abnormal_hematopoietic_system1.94207816
31MP0005025_abnormal_response_to1.92366878
32MP0003279_aneurysm1.88134611
33MP0002398_abnormal_bone_marrow1.87395840
34MP0002405_respiratory_system_inflammati1.86910698
35MP0003828_pulmonary_edema1.83827808
36MP0001873_stomach_inflammation1.81142915
37MP0005451_abnormal_body_composition1.80593235
38MP0009333_abnormal_splenocyte_physiolog1.80119058
39MP0006054_spinal_hemorrhage1.72378229
40MP0010155_abnormal_intestine_physiology1.70363591
41MP0003091_abnormal_cell_migration1.69808383
42MP0003172_abnormal_lysosome_physiology1.69077056
43MP0002419_abnormal_innate_immunity1.68129545
44MP0000716_abnormal_immune_system1.65571922
45MP0003448_altered_tumor_morphology1.64800166
46MP0000569_abnormal_digit_pigmentation1.61525922
47MP0005623_abnormal_meninges_morphology1.56621223
48MP0004947_skin_inflammation1.46819080
49MP0003566_abnormal_cell_adhesion1.46243825
50MP0002933_joint_inflammation1.42347753
51MP0002722_abnormal_immune_system1.41744915
52MP0001853_heart_inflammation1.41671919
53MP0000703_abnormal_thymus_morphology1.40442991
54MP0001533_abnormal_skeleton_physiology1.40262191
55MP0002138_abnormal_hepatobiliary_system1.39626023
56MP0003191_abnormal_cellular_cholesterol1.39378400
57MP0002429_abnormal_blood_cell1.38608051
58MP0004381_abnormal_hair_follicle1.38316475
59MP0008260_abnormal_autophagy1.34616757
60MP0006082_CNS_inflammation1.34151767
61MP0000689_abnormal_spleen_morphology1.33151484
62MP0001958_emphysema1.30903399
63MP0001348_abnormal_lacrimal_gland1.30516868
64MP0005167_abnormal_blood-brain_barrier1.28734623
65MP0005464_abnormal_platelet_physiology1.25244376
66MP0000767_abnormal_smooth_muscle1.24858006
67MP0008004_abnormal_stomach_pH1.23485467
68MP0001845_abnormal_inflammatory_respons1.21784417
69MP0004883_abnormal_blood_vessel1.19754767
70MP0003705_abnormal_hypodermis_morpholog1.18929398
71MP0000733_abnormal_muscle_development1.13584957
72MP0005076_abnormal_cell_differentiation1.12459804
73MP0000015_abnormal_ear_pigmentation1.11270697
74MP0000343_altered_response_to1.09812721
75MP0000858_altered_metastatic_potential1.08664797
76MP0002877_abnormal_melanocyte_morpholog1.08652323
77MP0000465_gastrointestinal_hemorrhage1.08568418
78MP0002998_abnormal_bone_remodeling1.08325776
79MP0005023_abnormal_wound_healing1.07609044
80MP0003045_fibrosis1.06734673
81MP0005058_abnormal_lysosome_morphology1.06569868
82MP0008438_abnormal_cutaneous_collagen1.04715286
83MP0000249_abnormal_blood_vessel1.04332099
84MP0008057_abnormal_DNA_replication1.03620826
85MP0004084_abnormal_cardiac_muscle1.03267088
86MP0001851_eye_inflammation1.02290789
87MP0008775_abnormal_heart_ventricle0.98515358
88MP0003075_altered_response_to0.96471359
89MP0005310_abnormal_salivary_gland0.96352291
90MP0005166_decreased_susceptibility_to0.95273887
91MP0002128_abnormal_blood_circulation0.94582323
92MP0003866_abnormal_defecation0.93541459
93MP0002925_abnormal_cardiovascular_devel0.93155931
94MP0003943_abnormal_hepatobiliary_system0.90485897
95MP0000604_amyloidosis0.88406880
96MP0002009_preneoplasia0.84871082
97MP0005075_abnormal_melanosome_morpholog0.84690123
98MP0009764_decreased_sensitivity_to0.82875464
99MP0010630_abnormal_cardiac_muscle0.78586034
100MP0002332_abnormal_exercise_endurance0.77938402
101MP0001614_abnormal_blood_vessel0.77669182
102MP0005165_increased_susceptibility_to0.77496371
103MP0004782_abnormal_surfactant_physiolog0.76101759
104MP0009763_increased_sensitivity_to0.75995200
105MP0008469_abnormal_protein_level0.72643449
106MP0003795_abnormal_bone_structure0.71162752
107MP0000490_abnormal_crypts_of0.70135657
108MP0005390_skeleton_phenotype0.69786828
109MP0004484_altered_response_of0.69385624
110MP0002295_abnormal_pulmonary_circulatio0.69216042
111MP0006138_congestive_heart_failure0.68615295
112MP0005164_abnormal_response_to0.67880341
113MP0003453_abnormal_keratinocyte_physiol0.66648868
114MP0004147_increased_porphyrin_level0.66553228
115MP0004130_abnormal_muscle_cell0.66548744
116MP0003690_abnormal_glial_cell0.65916164
117MP0009115_abnormal_fat_cell0.65861962
118MP0002019_abnormal_tumor_incidence0.65735793
119MP0010307_abnormal_tumor_latency0.65274627
120MP0001663_abnormal_digestive_system0.62566611
121MP0005385_cardiovascular_system_phenoty0.62279523
122MP0001544_abnormal_cardiovascular_syste0.62279523
123MP0005409_darkened_coat_color0.61964762
124MP0001915_intracranial_hemorrhage0.61193332

Predicted human phenotypes

RankGene SetZ-score
1Interstitial pulmonary disease (HP:0006530)3.88943699
2Chronic otitis media (HP:0000389)3.80228989
3Spontaneous hematomas (HP:0007420)3.57403445
4Elevated erythrocyte sedimentation rate (HP:0003565)3.41960837
5Abnormality of the nasal mucosa (HP:0000433)3.40367801
6Hematochezia (HP:0002573)3.38161744
7Abnormality of T cell number (HP:0011839)3.34781422
8Myositis (HP:0100614)3.31454742
9Autoimmune hemolytic anemia (HP:0001890)3.22943922
10Gastrointestinal infarctions (HP:0005244)3.21486031
11Recurrent viral infections (HP:0004429)3.19187347
12T lymphocytopenia (HP:0005403)3.16505432
13Eczematoid dermatitis (HP:0000976)3.14145237
14Recurrent fungal infections (HP:0002841)3.06068611
15Recurrent abscess formation (HP:0002722)3.03026345
16Gingivitis (HP:0000230)3.02778630
17Recurrent bronchitis (HP:0002837)2.95448268
18Autoimmune thrombocytopenia (HP:0001973)2.90536162
19Nasal polyposis (HP:0100582)2.88955654
20Keratoconjunctivitis sicca (HP:0001097)2.87375350
21Polycythemia (HP:0001901)2.85721414
22Cellulitis (HP:0100658)2.71709229
23Granulocytopenia (HP:0001913)2.64578102
24Osteolytic defects of the phalanges of the hand (HP:0009771)2.64558240
25Osteolytic defects of the hand bones (HP:0009699)2.64558240
26Aortic aneurysm (HP:0004942)2.63797957
27Mediastinal lymphadenopathy (HP:0100721)2.62890549
28Encephalitis (HP:0002383)2.59813858
29Increased density of long bones (HP:0006392)2.56230409
30Keratoconjunctivitis (HP:0001096)2.55407408
31Optic neuritis (HP:0100653)2.55140786
32Retrobulbar optic neuritis (HP:0100654)2.55140786
33Recurrent gram-negative bacterial infections (HP:0005420)2.53856257
34Abnormality of the fingertips (HP:0001211)2.52519581
35Cerebral aneurysm (HP:0004944)2.52239832
36Orchitis (HP:0100796)2.51385058
37Abnormality of T cells (HP:0002843)2.47076383
38Abnormal delayed hypersensitivity skin test (HP:0002963)2.42720867
39Colitis (HP:0002583)2.38222920
40Gingival bleeding (HP:0000225)2.38143716
41Increased IgE level (HP:0003212)2.37797549
42Vasculitis (HP:0002633)2.37643929
43Abnormality of liposaccharide metabolism (HP:0010968)2.37581286
44Abnormality of glycosphingolipid metabolism (HP:0004343)2.37581286
45Abnormality of glycolipid metabolism (HP:0010969)2.37581286
46Panhypogammaglobulinemia (HP:0003139)2.36517910
47Porencephaly (HP:0002132)2.35935012
48Spondylolisthesis (HP:0003302)2.35006150
49Arterial thrombosis (HP:0004420)2.34927567
50Stomatitis (HP:0010280)2.30979958
51Meningitis (HP:0001287)2.29036796
52Aortic dissection (HP:0002647)2.28650048
53Increased IgM level (HP:0003496)2.26534804
54Agammaglobulinemia (HP:0004432)2.26392680
55Recurrent cutaneous fungal infections (HP:0011370)2.23018328
56Chronic mucocutaneous candidiasis (HP:0002728)2.23018328
57Chronic diarrhea (HP:0002028)2.22571398
58Thick nail (HP:0001805)2.22257180
59Protrusio acetabuli (HP:0003179)2.20081606
60Pulmonary infiltrates (HP:0002113)2.19779716
61Prolonged bleeding time (HP:0003010)2.19547845
62Lymphopenia (HP:0001888)2.18803656
63Asymmetry of the thorax (HP:0001555)2.18036096
64Slow saccadic eye movements (HP:0000514)2.17229330
65Acute myeloid leukemia (HP:0004808)2.16780725
66Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.16369925
67Urticaria (HP:0001025)2.15756729
68Osteomyelitis (HP:0002754)2.14363852
69Pulmonary embolism (HP:0002204)2.13706606
70IgA deficiency (HP:0002720)2.13569886
71Abnormality of cells of the lymphoid lineage (HP:0012140)2.13253262
72Syringomyelia (HP:0003396)2.12543165
73Spinal cord lesions (HP:0100561)2.12543165
74Dilatation of the ascending aorta (HP:0005111)2.12371658
75Recurrent bacterial skin infections (HP:0005406)2.11806023
76Eosinophilia (HP:0001880)2.07781720
77Papilloma (HP:0012740)2.07475120
78Verrucae (HP:0200043)2.07475120
79Esophageal varix (HP:0002040)2.07144279
80Abnormality of macrophages (HP:0004311)2.05993908
81Combined immunodeficiency (HP:0005387)2.05913396
82Subacute progressive viral hepatitis (HP:0006572)2.04845685
83Abnormality of the vasculature of the conjunctiva (HP:0008054)2.04669315
84Pustule (HP:0200039)2.03809887
85Milia (HP:0001056)2.03462419
86Conjunctival telangiectasia (HP:0000524)2.02440886
87Skin ulcer (HP:0200042)2.01950242
88Glomerulopathy (HP:0100820)2.01138119
89Hemoptysis (HP:0002105)2.00727282
90Increased cerebral lipofuscin (HP:0011813)2.00380450
91Inflammation of the large intestine (HP:0002037)2.00017011
92Amaurosis fugax (HP:0100576)1.99444718
93Petechiae (HP:0000967)1.98783421
94Leukocytosis (HP:0001974)1.97189735
95Hypergammaglobulinemia (HP:0010702)1.95374096
96Abnormal platelet volume (HP:0011876)1.95243699
97Abnormality of the peritoneum (HP:0002585)1.91958165
98Gangrene (HP:0100758)1.91219227
99Bicuspid aortic valve (HP:0001647)1.90072704
100Amyloidosis (HP:0011034)1.89976149
101Chronic sinusitis (HP:0011109)1.89168827
102Gastrointestinal inflammation (HP:0004386)1.88543699
103Peritonitis (HP:0002586)1.86743160
104IgM deficiency (HP:0002850)1.86324676
105Thrombocytosis (HP:0001894)1.85954378
106Chronic obstructive pulmonary disease (HP:0006510)1.85102125
107Obstructive lung disease (HP:0006536)1.85102125
108Absent frontal sinuses (HP:0002688)1.84444808
109Dysostosis multiplex (HP:0000943)1.84294112
110Glucose intolerance (HP:0000833)1.84281689
111Adactyly (HP:0009776)1.84154976
112Persistence of primary teeth (HP:0006335)1.83690088
113Thyroiditis (HP:0100646)1.83036576
114Recurrent skin infections (HP:0001581)1.82089607
115Abnormality of the prostate (HP:0008775)1.81715592
116Vertebral compression fractures (HP:0002953)1.80657666
117Epistaxis (HP:0000421)1.79625237
118Emphysema (HP:0002097)1.79242803
119Broad face (HP:0000283)1.79035559
120Abnormality of eosinophils (HP:0001879)1.78780086
121Abnormality of T cell physiology (HP:0011840)1.78092809
122Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.78039404
123Short 4th metacarpal (HP:0010044)1.78039404
124Chest pain (HP:0100749)1.77320265
125Joint swelling (HP:0001386)1.76330362
126Acrocyanosis (HP:0001063)1.74541783
127Pulmonary artery stenosis (HP:0004415)1.74316463
128Nonimmune hydrops fetalis (HP:0001790)1.73823243
129Fatigue (HP:0012378)1.73551084
130Periodontitis (HP:0000704)1.73397065
131Increased mean platelet volume (HP:0011877)1.72794960
132Abnormality of B cell number (HP:0010975)1.72711475
133B lymphocytopenia (HP:0010976)1.72711475
134IgG deficiency (HP:0004315)1.72642689
135Severe combined immunodeficiency (HP:0004430)1.72562781
136Vertebral arch anomaly (HP:0008438)1.72555638

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KDR3.92741504
2MAP4K13.59579934
3JAK33.14677194
4PRPF4B3.10564348
5TIE13.00330927
6MAP3K142.98556178
7TXK2.80514522
8STK102.75379134
9TYK22.40753690
10TBK12.19048697
11JAK12.15469614
12LRRK22.07975236
13ZAP702.04167449
14EPHB11.94860281
15TGFBR21.93374256
16IKBKE1.85658210
17RIPK11.80508942
18FGFR31.79996944
19ITK1.79563147
20NLK1.72574648
21DMPK1.67969454
22KIT1.64133541
23TAOK31.61633380
24CAMKK21.60496976
25TGFBR11.56876222
26BMPR21.54608711
27TEC1.53678544
28PIM21.51452099
29PIK3CG1.50258002
30TTN1.48296104
31IKBKB1.46183448
32MST41.44835495
33MAP3K101.42129022
34CSK1.39413162
35FGFR41.35856789
36STK241.27607365
37NEK91.25750127
38CHUK1.24658035
39TRIB31.24074976
40LCK1.19528012
41SIK31.19143907
42IRAK31.18004739
43PTK2B1.17047581
44MAP3K31.16104036
45MAP3K131.13140684
46MARK31.12700595
47PKN21.12217674
48PIM11.11037686
49TRPM71.10331656
50BTK1.08048469
51HCK1.06658880
52SYK1.06392260
53EPHA31.06068463
54EEF2K1.05736347
55GRK71.01644374
56PTK61.01324544
57FGR0.99319646
58ERN10.99259748
59MAP3K10.98974949
60CDK120.96757345
61TAOK20.94884572
62PRKCQ0.94173113
63MOS0.91892069
64RPS6KA40.90624430
65CLK10.90454188
66MAPK70.88324424
67KSR20.86115049
68PRKCH0.86049632
69PRKG20.84250129
70SCYL20.80505986
71CDK60.80449167
72CAMKK10.78423168
73JAK20.77423444
74PDGFRB0.75667686
75FLT30.75015603
76PASK0.73660013
77BRD40.71559307
78BLK0.70549485
79STK40.70477570
80FES0.69852410
81GRK60.69844530
82SIK20.69530783
83EGFR0.66681942
84BMX0.64704454
85PTK20.62939349
86YES10.61582654
87STK30.60860425
88CSF1R0.57194119
89MAP3K60.56950012
90MAPKAPK20.56087392
91MATK0.55989092
92MAP2K30.55744822
93IRAK10.55110358
94TNK20.54582789
95MAPK110.53813581
96ILK0.53750535
97MAP3K70.53084374
98PDPK10.53074298
99MAP3K20.52201716
100RET0.51910371
101PAK40.51738081
102LYN0.51629298
103MARK20.50340350
104IRAK40.49497942
105SMG10.48536080
106MAP3K120.47617466
107IGF1R0.46975624
108STK380.45590716
109BRSK20.44197037
110TYRO30.43888898
111INSR0.43600622
112CDC42BPA0.43016324
113MYLK0.42543641
114SGK30.42467390
115TAOK10.42332936
116MAPK120.42204456
117MELK0.41961496
118WNK10.40046466
119SRC0.39248634
120MAP3K50.38703155
121NME20.37681009
122RPS6KL10.37450499
123RPS6KC10.37450499
124ROCK20.36935171
125ABL10.36478677
126CAMK40.35664673
127PRKD20.35502180
128CDK40.34025605
129MAP3K110.33821032
130FGFR20.33697055
131ALK0.33462288
132RIPK40.33083812
133PDGFRA0.32751556
134MAPK40.31485494
135FYN0.30885136
136PAK20.30240219
137PDK10.28637897
138HIPK20.27245602

Predicted pathways (KEGG)

RankGene SetZ-score
1Allograft rejection_Homo sapiens_hsa053302.27460127
2Primary immunodeficiency_Homo sapiens_hsa053402.15827371
3Graft-versus-host disease_Homo sapiens_hsa053322.11078535
4Leishmaniasis_Homo sapiens_hsa051402.05437774
5Measles_Homo sapiens_hsa051622.03100352
6NF-kappa B signaling pathway_Homo sapiens_hsa040642.00856093
7Intestinal immune network for IgA production_Homo sapiens_hsa046721.98735919
8Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.93655564
9Viral myocarditis_Homo sapiens_hsa054161.93185568
10Osteoclast differentiation_Homo sapiens_hsa043801.79414291
11Toxoplasmosis_Homo sapiens_hsa051451.77915906
12Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.73622273
13Hematopoietic cell lineage_Homo sapiens_hsa046401.66464433
14T cell receptor signaling pathway_Homo sapiens_hsa046601.65857965
15Malaria_Homo sapiens_hsa051441.64440670
16Autoimmune thyroid disease_Homo sapiens_hsa053201.59133118
17B cell receptor signaling pathway_Homo sapiens_hsa046621.59044391
18AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.56959509
19Shigellosis_Homo sapiens_hsa051311.56498165
20Jak-STAT signaling pathway_Homo sapiens_hsa046301.55278248
21TNF signaling pathway_Homo sapiens_hsa046681.53881465
22Small cell lung cancer_Homo sapiens_hsa052221.53102951
23Leukocyte transendothelial migration_Homo sapiens_hsa046701.50768456
24Antigen processing and presentation_Homo sapiens_hsa046121.50157130
25Staphylococcus aureus infection_Homo sapiens_hsa051501.50020543
26Toll-like receptor signaling pathway_Homo sapiens_hsa046201.46802913
27Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.40930308
28NOD-like receptor signaling pathway_Homo sapiens_hsa046211.35236494
29Chronic myeloid leukemia_Homo sapiens_hsa052201.33514328
30Chemokine signaling pathway_Homo sapiens_hsa040621.33002861
31Focal adhesion_Homo sapiens_hsa045101.30135205
32Platelet activation_Homo sapiens_hsa046111.29354153
33RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.27923039
34Hepatitis B_Homo sapiens_hsa051611.27734604
35ECM-receptor interaction_Homo sapiens_hsa045121.26412785
36Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.26162215
37Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.24995857
38Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.22947136
39Apoptosis_Homo sapiens_hsa042101.21717835
40Type I diabetes mellitus_Homo sapiens_hsa049401.20546990
41Influenza A_Homo sapiens_hsa051641.17844075
42Herpes simplex infection_Homo sapiens_hsa051681.16978661
43Acute myeloid leukemia_Homo sapiens_hsa052211.16931093
44Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.14876605
45Pertussis_Homo sapiens_hsa051331.13700513
46Pancreatic cancer_Homo sapiens_hsa052121.13603081
47Salmonella infection_Homo sapiens_hsa051321.12729919
48African trypanosomiasis_Homo sapiens_hsa051431.06084647
49Adherens junction_Homo sapiens_hsa045201.04558300
50Proteoglycans in cancer_Homo sapiens_hsa052051.03264806
51Tuberculosis_Homo sapiens_hsa051521.02525651
52Regulation of actin cytoskeleton_Homo sapiens_hsa048101.02474108
53HTLV-I infection_Homo sapiens_hsa051660.99719251
54Other glycan degradation_Homo sapiens_hsa005110.98092794
55Dorso-ventral axis formation_Homo sapiens_hsa043200.98004238
56Asthma_Homo sapiens_hsa053100.97909801
57Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.97293961
58Neurotrophin signaling pathway_Homo sapiens_hsa047220.95573542
59Amoebiasis_Homo sapiens_hsa051460.95361087
60VEGF signaling pathway_Homo sapiens_hsa043700.94978741
61MicroRNAs in cancer_Homo sapiens_hsa052060.94759426
62Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.94460868
63Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.91448097
64Colorectal cancer_Homo sapiens_hsa052100.88827414
65Legionellosis_Homo sapiens_hsa051340.88251283
66Renal cell carcinoma_Homo sapiens_hsa052110.88006790
67Prolactin signaling pathway_Homo sapiens_hsa049170.86347779
68Rheumatoid arthritis_Homo sapiens_hsa053230.86204614
69Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.86000927
70Hepatitis C_Homo sapiens_hsa051600.84307965
71Viral carcinogenesis_Homo sapiens_hsa052030.84088682
72Dilated cardiomyopathy_Homo sapiens_hsa054140.81790282
73Glycosaminoglycan degradation_Homo sapiens_hsa005310.80718662
74Phosphatidylinositol signaling system_Homo sapiens_hsa040700.79892558
75Rap1 signaling pathway_Homo sapiens_hsa040150.79747430
76Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.79532132
77PI3K-Akt signaling pathway_Homo sapiens_hsa041510.77191319
78Pathways in cancer_Homo sapiens_hsa052000.76923820
79Transcriptional misregulation in cancer_Homo sapiens_hsa052020.73238022
80HIF-1 signaling pathway_Homo sapiens_hsa040660.72482808
81Endocytosis_Homo sapiens_hsa041440.72100174
82Epstein-Barr virus infection_Homo sapiens_hsa051690.70577457
83Sphingolipid signaling pathway_Homo sapiens_hsa040710.70310680
84mTOR signaling pathway_Homo sapiens_hsa041500.69601466
85p53 signaling pathway_Homo sapiens_hsa041150.69288610
86Prostate cancer_Homo sapiens_hsa052150.68250943
87Thyroid cancer_Homo sapiens_hsa052160.67494865
88MAPK signaling pathway_Homo sapiens_hsa040100.66263850
89Glioma_Homo sapiens_hsa052140.65962768
90Thyroid hormone signaling pathway_Homo sapiens_hsa049190.65749354
91Non-small cell lung cancer_Homo sapiens_hsa052230.65075922
92Lysosome_Homo sapiens_hsa041420.65054656
93Inositol phosphate metabolism_Homo sapiens_hsa005620.64820128
94Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.64025225
95Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.61435037
96Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.61112905
97Endometrial cancer_Homo sapiens_hsa052130.60723423
98FoxO signaling pathway_Homo sapiens_hsa040680.56832199
99Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.56636346
100Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.56080317
101Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.54433631
102GnRH signaling pathway_Homo sapiens_hsa049120.54004348
103Phospholipase D signaling pathway_Homo sapiens_hsa040720.52433846
104Phagosome_Homo sapiens_hsa041450.52384379
105TGF-beta signaling pathway_Homo sapiens_hsa043500.52210047
106Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.51399813
107Long-term potentiation_Homo sapiens_hsa047200.47988786
108Choline metabolism in cancer_Homo sapiens_hsa052310.47701985
109Ras signaling pathway_Homo sapiens_hsa040140.47509223
110Adipocytokine signaling pathway_Homo sapiens_hsa049200.44757107
111Notch signaling pathway_Homo sapiens_hsa043300.44342296
112ErbB signaling pathway_Homo sapiens_hsa040120.43683971
113Insulin resistance_Homo sapiens_hsa049310.42848284
114Melanoma_Homo sapiens_hsa052180.42674700
115Bladder cancer_Homo sapiens_hsa052190.40933771

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