LRRC8D

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1central nervous system myelination (GO:0022010)8.13946198
2axon ensheathment in central nervous system (GO:0032291)8.13946198
3fatty acid elongation (GO:0030497)6.50831878
4nuclear pore complex assembly (GO:0051292)5.46560564
5amyloid precursor protein metabolic process (GO:0042982)4.98428129
6response to lipoprotein particle (GO:0055094)4.63641521
7myelination (GO:0042552)4.55057072
8ensheathment of neurons (GO:0007272)4.54513699
9axon ensheathment (GO:0008366)4.54513699
10response to methylmercury (GO:0051597)4.43154175
11nuclear pore organization (GO:0006999)4.40910364
12thrombin receptor signaling pathway (GO:0070493)4.38714101
13long-chain fatty acid biosynthetic process (GO:0042759)4.35496587
14regulation of histone H3-K9 methylation (GO:0051570)4.28883502
15amyloid precursor protein catabolic process (GO:0042987)4.23143685
16long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)4.19502605
17Arp2/3 complex-mediated actin nucleation (GO:0034314)4.09600627
18pore complex assembly (GO:0046931)4.07470839
19cholesterol biosynthetic process (GO:0006695)4.03073677
20positive regulation of oligodendrocyte differentiation (GO:0048714)4.01570734
21positive regulation of gamma-delta T cell activation (GO:0046645)3.96988375
22negative regulation of histone methylation (GO:0031061)3.94454558
23regulation of collateral sprouting (GO:0048670)3.85982965
24megakaryocyte development (GO:0035855)3.77964418
25protein neddylation (GO:0045116)3.77582951
26sterol biosynthetic process (GO:0016126)3.75238249
27long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.71836460
28regulation of B cell receptor signaling pathway (GO:0050855)3.69236900
29myelin maintenance (GO:0043217)3.68828605
30fatty-acyl-CoA biosynthetic process (GO:0046949)3.61693923
31positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.59237340
32neutrophil activation involved in immune response (GO:0002283)3.58688731
33regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)3.58614917
34platelet aggregation (GO:0070527)3.45297104
35glycosylceramide metabolic process (GO:0006677)3.38422469
36negative regulation of neurotransmitter secretion (GO:0046929)3.37721637
37negative thymic T cell selection (GO:0045060)3.34442843
38regulation of platelet aggregation (GO:0090330)3.32363795
39negative regulation of neurotransmitter transport (GO:0051589)3.31483177
40developmental pigmentation (GO:0048066)3.31314909
41L-phenylalanine catabolic process (GO:0006559)3.22684675
42erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.22684675
43regulation of translational fidelity (GO:0006450)3.21648051
44leukocyte migration involved in inflammatory response (GO:0002523)3.21110983
45nerve growth factor signaling pathway (GO:0038180)3.20776062
46eye photoreceptor cell differentiation (GO:0001754)3.20288259
47photoreceptor cell differentiation (GO:0046530)3.20288259
48negative T cell selection (GO:0043383)3.20030842
49fatty-acyl-CoA metabolic process (GO:0035337)3.19259537
50isoprenoid biosynthetic process (GO:0008299)3.17893224
51positive regulation of toll-like receptor signaling pathway (GO:0034123)3.16262923
52very long-chain fatty acid metabolic process (GO:0000038)3.14596303
53positive regulation of granulocyte differentiation (GO:0030854)3.13931067
54L-amino acid import (GO:0043092)3.12496543
55positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.05503141
56actin nucleation (GO:0045010)3.04017436
57antigen processing and presentation via MHC class Ib (GO:0002475)3.01099997
58positive regulation of humoral immune response (GO:0002922)3.00742057
59blood coagulation, intrinsic pathway (GO:0007597)3.00082866
60signal peptide processing (GO:0006465)2.99530982
61regulation of Golgi to plasma membrane protein transport (GO:0042996)2.97644784
62antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.97346852
63regulation of lipoprotein metabolic process (GO:0050746)2.95064771
64regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.93955736
65nucleotide transmembrane transport (GO:1901679)2.90363004
66regulation of platelet activation (GO:0010543)2.88691052
67mast cell activation (GO:0045576)2.86109621
68interleukin-6-mediated signaling pathway (GO:0070102)2.85533649
69oligodendrocyte differentiation (GO:0048709)2.84263484
70negative regulation of norepinephrine secretion (GO:0010700)2.82799423
71establishment of mitochondrion localization (GO:0051654)2.82485625
72response to dietary excess (GO:0002021)2.80860510
73magnesium ion transport (GO:0015693)2.78778653
74G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.78155645
75peptidyl-tyrosine autophosphorylation (GO:0038083)2.76153396
76import into cell (GO:0098657)2.72234883
77positive regulation of immunoglobulin mediated immune response (GO:0002891)2.71687395
78positive regulation of B cell mediated immunity (GO:0002714)2.71687395
79positive regulation of mast cell activation (GO:0033005)2.71285227
80peptidyl-arginine omega-N-methylation (GO:0035247)2.70623122
81negative regulation of cell killing (GO:0031342)2.70444073
82negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.70444073
83homotypic cell-cell adhesion (GO:0034109)2.69472378
84melanin biosynthetic process (GO:0042438)2.67611408
85response to muramyl dipeptide (GO:0032495)2.66698545
86protein palmitoylation (GO:0018345)2.65718037
87beta-amyloid metabolic process (GO:0050435)2.65282742
88astrocyte differentiation (GO:0048708)2.64909846
89negative regulation of chemokine production (GO:0032682)2.64524010
90positive regulation of alpha-beta T cell proliferation (GO:0046641)2.62977088
91regulation of regulatory T cell differentiation (GO:0045589)2.62533722
92purine nucleobase biosynthetic process (GO:0009113)2.62355134
93antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.62149662
94GPI anchor biosynthetic process (GO:0006506)2.61807438
95erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.61207859
96L-phenylalanine metabolic process (GO:0006558)2.61207859
97adenosine receptor signaling pathway (GO:0001973)2.60730183
98positive regulation of glial cell differentiation (GO:0045687)2.60590694
99GPI anchor metabolic process (GO:0006505)2.60257608
100glycerophospholipid catabolic process (GO:0046475)2.57228663
101melanin metabolic process (GO:0006582)2.56368110
102autophagic vacuole fusion (GO:0000046)2.55768899
103antigen processing and presentation of endogenous antigen (GO:0019883)2.54987104
104positive regulation by symbiont of host defense response (GO:0052509)2.54972503
105modulation by symbiont of host defense response (GO:0052031)2.54972503
106modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.54972503
107modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.54972503
108positive regulation by organism of defense response of other organism involved in symbiotic interact2.54972503
109modulation by symbiont of host immune response (GO:0052553)2.54972503
110negative regulation of execution phase of apoptosis (GO:1900118)2.54653238
111tRNA aminoacylation for protein translation (GO:0006418)2.54215944
112amino acid import (GO:0043090)2.51814165
113positive regulation of gliogenesis (GO:0014015)2.51376686
114tyrosine metabolic process (GO:0006570)2.51104403
115negative regulation of homotypic cell-cell adhesion (GO:0034111)2.50478202
116positive regulation of cellular amine metabolic process (GO:0033240)2.50387050
117regulation of B cell mediated immunity (GO:0002712)2.50313541
118positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.50120452
119neutrophil activation (GO:0042119)2.49942183
120mast cell degranulation (GO:0043303)2.49651849
121mast cell activation involved in immune response (GO:0002279)2.49651849
122lymph node development (GO:0048535)2.48907395
123amino acid activation (GO:0043038)2.48488754
124tRNA aminoacylation (GO:0043039)2.48488754
125regulation of hypersensitivity (GO:0002883)2.47798373
126negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.47188117
127negative regulation of T-helper cell differentiation (GO:0045623)2.47188117
128membrane protein ectodomain proteolysis (GO:0006509)2.46465119
129glutathione biosynthetic process (GO:0006750)2.44598689
130regulation of gamma-delta T cell differentiation (GO:0045586)2.44506568
131mitochondrial calcium ion transport (GO:0006851)2.44273584
132negative regulation of acute inflammatory response (GO:0002674)2.44068167
133negative regulation of hydrogen peroxide-induced cell death (GO:1903206)2.43881871
134regulation of histone H3-K4 methylation (GO:0051569)2.43567844
135acyl-CoA biosynthetic process (GO:0071616)2.43530071
136thioester biosynthetic process (GO:0035384)2.43530071
137response to interleukin-15 (GO:0070672)2.43204449
138intracellular pH reduction (GO:0051452)2.42487055
139positive regulation of B cell differentiation (GO:0045579)2.42148185
140nonribosomal peptide biosynthetic process (GO:0019184)2.42142988
141drug transmembrane transport (GO:0006855)2.42000975
142leukocyte aggregation (GO:0070486)2.41348158
143positive regulation of blood coagulation (GO:0030194)2.40554557
144positive regulation of hemostasis (GO:1900048)2.40554557
145respiratory burst (GO:0045730)2.40502801
146leukocyte degranulation (GO:0043299)2.39434374
147secondary metabolite biosynthetic process (GO:0044550)2.39230104
148ribosomal small subunit biogenesis (GO:0042274)2.38398925
149tolerance induction (GO:0002507)2.38309158
150enteric nervous system development (GO:0048484)2.38202648
151pH reduction (GO:0045851)2.38141765
152detection of temperature stimulus involved in sensory perception (GO:0050961)2.37546082
153detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.37546082
154positive regulation of macrophage differentiation (GO:0045651)2.37141364
155regulation of RNA export from nucleus (GO:0046831)2.35786766
156positive regulation of histone methylation (GO:0031062)2.35297854
157negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.34783109
158regulation of immunoglobulin mediated immune response (GO:0002889)2.34649272
159maturation of SSU-rRNA (GO:0030490)2.34138250
160platelet formation (GO:0030220)2.33806342
161negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.33151057
162thymic T cell selection (GO:0045061)2.33109760
163response to nerve growth factor (GO:1990089)2.32955127
164cellular response to nerve growth factor stimulus (GO:1990090)2.32955127
165preassembly of GPI anchor in ER membrane (GO:0016254)2.32759897
166viral entry into host cell (GO:0046718)2.31821008
167protein export from nucleus (GO:0006611)2.31815599
168T-helper 1 type immune response (GO:0042088)2.31677962
169nucleobase biosynthetic process (GO:0046112)2.31352316
170T cell proliferation (GO:0042098)2.31252367
171T cell selection (GO:0045058)2.31192095
172proline biosynthetic process (GO:0006561)2.30478625
173protein localization to microtubule (GO:0035372)2.30065808
174regulation of integrin activation (GO:0033623)2.29921014
175granulocyte activation (GO:0036230)2.29612191
176regulation of cytokine production involved in inflammatory response (GO:1900015)2.29287328
177cranial nerve development (GO:0021545)2.29191948
178positive regulation of pseudopodium assembly (GO:0031274)2.28929631
179regulation of gamma-delta T cell activation (GO:0046643)2.28774103
180localization within membrane (GO:0051668)2.28633807
181negative regulation of calcium ion transport into cytosol (GO:0010523)2.28368838
182entry into host (GO:0044409)2.27505904
183entry into other organism involved in symbiotic interaction (GO:0051828)2.27505904
184movement in host environment (GO:0052126)2.27505904
185entry into host cell (GO:0030260)2.27505904
186movement in environment of other organism involved in symbiotic interaction (GO:0052192)2.27505904
187entry into cell of other organism involved in symbiotic interaction (GO:0051806)2.27505904
188regulation of vacuole organization (GO:0044088)2.27373525
189histone H2B ubiquitination (GO:0033523)2.26908191
190B cell mediated immunity (GO:0019724)2.26834609
191phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.26293389
192positive regulation of isotype switching (GO:0045830)2.25943309
193sphingomyelin metabolic process (GO:0006684)2.25548375
194cofactor catabolic process (GO:0051187)2.25047865

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.89879242
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.01766333
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.40175384
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.14985567
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.05207570
6VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.71383620
7MYC_18555785_ChIP-Seq_MESCs_Mouse2.61636348
8* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.57976851
9ELF1_17652178_ChIP-ChIP_JURKAT_Human2.55150471
10* MYC_22102868_ChIP-Seq_BL_Human2.46681850
11E2F4_17652178_ChIP-ChIP_JURKAT_Human2.37753532
12GATA1_22025678_ChIP-Seq_K562_Human2.28229310
13IRF8_27001747_Chip-Seq_BMDM_Mouse2.25713935
14SCL_19346495_ChIP-Seq_HPC-7_Human2.25677903
15MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.20591262
16Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.18865742
17STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.16438955
18RUNX_20019798_ChIP-Seq_JUKART_Human2.10167260
19SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.08822413
20TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.07719592
21GBX2_23144817_ChIP-Seq_PC3_Human2.03339687
22HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.03215564
23EGR1_19374776_ChIP-ChIP_THP-1_Human2.02948508
24HOXB4_20404135_ChIP-ChIP_EML_Mouse2.00379068
25MYC_19079543_ChIP-ChIP_MESCs_Mouse2.00147878
26* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.97071460
27* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.93793619
28* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.88795863
29ZNF263_19887448_ChIP-Seq_K562_Human1.87323178
30BP1_19119308_ChIP-ChIP_Hs578T_Human1.86499388
31SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.82775420
32IRF8_22096565_ChIP-ChIP_GC-B_Human1.82733180
33NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.76286453
34E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.74097590
35ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.73301391
36PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.72211428
37WT1_19549856_ChIP-ChIP_CCG9911_Human1.71546500
38TFEB_21752829_ChIP-Seq_HELA_Human1.70627963
39TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.67842391
40MYB_26560356_Chip-Seq_TH1_Human1.66749404
41* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.66094080
42CDX2_19796622_ChIP-Seq_MESCs_Mouse1.65415456
43STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.64864920
44FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.61224871
45IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.61106207
46GATA2_21666600_ChIP-Seq_HMVEC_Human1.60683398
47FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.59320205
48OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.57509826
49FOXP3_21729870_ChIP-Seq_TREG_Human1.57203498
50STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.56929355
51UTX_26944678_Chip-Seq_JUKART_Human1.54816430
52MYC_18358816_ChIP-ChIP_MESCs_Mouse1.53938335
53KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.52587241
54NELFA_20434984_ChIP-Seq_ESCs_Mouse1.51188706
55THAP11_20581084_ChIP-Seq_MESCs_Mouse1.50642839
56FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.50535655
57MAF_26560356_Chip-Seq_TH1_Human1.48366856
58ERG_20887958_ChIP-Seq_HPC-7_Mouse1.47879325
59FOXM1_23109430_ChIP-Seq_U2OS_Human1.47864077
60ZFX_18555785_ChIP-Seq_MESCs_Mouse1.47519109
61CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.46074934
62LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.45688507
63GATA2_22383799_ChIP-Seq_G1ME_Mouse1.44693307
64ELK1_19687146_ChIP-ChIP_HELA_Human1.44001914
65* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.43256034
66ZNF217_24962896_ChIP-Seq_MCF-7_Human1.42523435
67RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.40632851
68KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.40177532
69PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.39921157
70TAF15_26573619_Chip-Seq_HEK293_Human1.37654387
71IGF1R_20145208_ChIP-Seq_DFB_Human1.36990864
72SOX2_27498859_Chip-Seq_STOMACH_Mouse1.36591231
73CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.35859447
74DCP1A_22483619_ChIP-Seq_HELA_Human1.35202381
75* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.34975898
76ER_23166858_ChIP-Seq_MCF-7_Human1.34803585
77PIAS1_25552417_ChIP-Seq_VCAP_Human1.34496912
78STAT6_21828071_ChIP-Seq_BEAS2B_Human1.34432811
79AR_21909140_ChIP-Seq_LNCAP_Human1.33852379
80VDR_24787735_ChIP-Seq_THP-1_Human1.33387892
81PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.31517213
82POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.30418038
83NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.30071784
84STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.29858023
85* ESR2_21235772_ChIP-Seq_MCF-7_Human1.29772572
86NCOR1_26117541_ChIP-Seq_K562_Human1.28154185
87ZFP57_27257070_Chip-Seq_ESCs_Mouse1.27094728
88NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.26539471
89SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.25656450
90EST1_17652178_ChIP-ChIP_JURKAT_Human1.24896255
91* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.23811809
92ETS1_22383799_ChIP-Seq_G1ME_Mouse1.23570860
93* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.22517920
94FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.22305542
95FOXO3_23340844_ChIP-Seq_DLD1_Human1.21098494
96NRF2_20460467_ChIP-Seq_MEFs_Mouse1.20511428
97NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.20511428
98E2F1_21310950_ChIP-Seq_MCF-7_Human1.17643900
99YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.17607266
100* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.17289038
101* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.16929461
102SRY_22984422_ChIP-ChIP_TESTIS_Rat1.16769163
103VDR_23849224_ChIP-Seq_CD4+_Human1.16130732
104SPI1_23127762_ChIP-Seq_K562_Human1.15912691
105IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.15478217
106* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.14830960
107MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.14456110
108SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.14194829
109STAT3_1855785_ChIP-Seq_MESCs_Mouse1.13894755
110AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.13856057
111* LXR_22158963_ChIP-Seq_LIVER_Mouse1.13768002
112VDR_21846776_ChIP-Seq_THP-1_Human1.12991084
113* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.12792635
114MAF_26560356_Chip-Seq_TH2_Human1.12537843
115XRN2_22483619_ChIP-Seq_HELA_Human1.12420735
116EGR1_19032775_ChIP-ChIP_M12_Human1.11695444
117STAT4_19710469_ChIP-ChIP_TH1__Mouse1.10999567
118SOX2_20726797_ChIP-Seq_SW620_Human1.10578071
119PU_27001747_Chip-Seq_BMDM_Mouse1.10139142
120TTF2_22483619_ChIP-Seq_HELA_Human1.09243728
121RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.07129284
122FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.06353660
123PADI4_21655091_ChIP-ChIP_MCF-7_Human1.05928922
124TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05607130
125POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.05603539
126EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.03962215
127* CHD1_26751641_Chip-Seq_LNCaP_Human1.03192356
128RUNX1_22412390_ChIP-Seq_EML_Mouse1.02766148
129STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.01934571
130ESR1_21235772_ChIP-Seq_MCF-7_Human1.01789740
131FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.01505942
132VDR_22108803_ChIP-Seq_LS180_Human1.00727023
133POU3F2_20337985_ChIP-ChIP_501MEL_Human0.99610449
134CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.99132638
135CMYC_18555785_Chip-Seq_ESCs_Mouse0.99114586
136* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.99026020
137SMAD3_21741376_ChIP-Seq_EPCs_Human0.98382843
138CIITA_25753668_ChIP-Seq_RAJI_Human0.97588769
139TCF7_22412390_ChIP-Seq_EML_Mouse0.97541440
140* RXR_22158963_ChIP-Seq_LIVER_Mouse0.97359987
141TAL1_26923725_Chip-Seq_HPCs_Mouse0.97289262
142GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96808483
143PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.96670625
144* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.96523972
145SUZ12_18555785_Chip-Seq_ESCs_Mouse0.95367812
146AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.94201488
147* GATA2_19941826_ChIP-Seq_K562_Human0.93786085
148TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.93665592
149GATA3_27048872_Chip-Seq_THYMUS_Human0.93083096
150MYB_26560356_Chip-Seq_TH2_Human0.92042206
151TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90644627
152GATA1_19941826_ChIP-Seq_K562_Human0.90635095
153AHR_22903824_ChIP-Seq_MCF-7_Human0.90292616
154PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.90263447
155VDR_24763502_ChIP-Seq_THP-1_Human0.89828380
156GATA3_26560356_Chip-Seq_TH2_Human0.89068822
157FOXA1_25552417_ChIP-Seq_VCAP_Human0.87754716
158ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.86296648
159* EGR1_23403033_ChIP-Seq_LIVER_Mouse0.85957204
160* SPI1_23547873_ChIP-Seq_NB4_Human0.85934745
161LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.84069799
162STAT3_23295773_ChIP-Seq_U87_Human0.83309318
163TP63_23658742_ChIP-Seq_EP156T_Human0.82018875
164P300_19829295_ChIP-Seq_ESCs_Human0.81158079
165* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80920567
166BRD4_27068464_Chip-Seq_AML-cells_Mouse0.80674425
167P63_26484246_Chip-Seq_KERATINOCYTES_Human0.80628057
168NFIB_24661679_ChIP-Seq_LUNG_Mouse0.80220044
169GATA1_19941827_ChIP-Seq_MEL_Mouse0.79288528
170NANOG_18555785_Chip-Seq_ESCs_Mouse0.78782523
171ARNT_22903824_ChIP-Seq_MCF-7_Human0.78750635

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000920_abnormal_myelination4.21637904
2MP0005171_absent_coat_pigmentation3.35520443
3MP0005408_hypopigmentation3.22861157
4MP0000372_irregular_coat_pigmentation3.11060075
5MP0003136_yellow_coat_color3.06671163
6MP0005058_abnormal_lysosome_morphology2.87247128
7MP0004381_abnormal_hair_follicle2.75816348
8MP0008057_abnormal_DNA_replication2.61486435
9MP0002009_preneoplasia2.50870278
10MP0002396_abnormal_hematopoietic_system2.32669775
11MP0003690_abnormal_glial_cell2.31377182
12MP0004957_abnormal_blastocyst_morpholog2.25257430
13MP0006082_CNS_inflammation2.23580223
14MP0003195_calcinosis2.22073017
15MP0003172_abnormal_lysosome_physiology2.19884991
16MP0009840_abnormal_foam_cell2.09801986
17MP0003111_abnormal_nucleus_morphology2.09667976
18MP0002398_abnormal_bone_marrow2.08569314
19MP0005174_abnormal_tail_pigmentation2.05990867
20MP0003763_abnormal_thymus_physiology2.04931101
21MP0003724_increased_susceptibility_to2.01623361
22MP0001986_abnormal_taste_sensitivity1.97043582
23MP0008004_abnormal_stomach_pH1.96185174
24MP0002166_altered_tumor_susceptibility1.88932420
25MP0000703_abnormal_thymus_morphology1.86373430
26MP0003300_gastrointestinal_ulcer1.81054626
27MP0002139_abnormal_hepatobiliary_system1.80488437
28MP0004885_abnormal_endolymph1.80368393
29MP0002419_abnormal_innate_immunity1.77487969
30MP0003693_abnormal_embryo_hatching1.76004202
31MP0009333_abnormal_splenocyte_physiolog1.74654142
32MP0002138_abnormal_hepatobiliary_system1.74267110
33MP0003566_abnormal_cell_adhesion1.73502121
34MP0009697_abnormal_copulation1.70996742
35MP0002722_abnormal_immune_system1.66934827
36MP0004043_abnormal_pH_regulation1.65825695
37MP0003950_abnormal_plasma_membrane1.65035295
38MP0003077_abnormal_cell_cycle1.63867524
39MP0000689_abnormal_spleen_morphology1.62995070
40MP0001730_embryonic_growth_arrest1.62579981
41MP0005000_abnormal_immune_tolerance1.60457045
42MP0003634_abnormal_glial_cell1.58326342
43MP0005387_immune_system_phenotype1.58225466
44MP0001790_abnormal_immune_system1.58225466
45MP0005075_abnormal_melanosome_morpholog1.56318501
46MP0008932_abnormal_embryonic_tissue1.51416138
47MP0005025_abnormal_response_to1.51352779
48MP0008058_abnormal_DNA_repair1.49534247
49MP0003329_amyloid_beta_deposits1.49341728
50MP0006035_abnormal_mitochondrial_morpho1.49062766
51MP0004742_abnormal_vestibular_system1.48506764
52MP0005409_darkened_coat_color1.45815479
53MP0002429_abnormal_blood_cell1.44684662
54MP0010094_abnormal_chromosome_stability1.43931321
55MP0005360_urolithiasis1.43650104
56MP0010155_abnormal_intestine_physiology1.36975193
57MP0000604_amyloidosis1.36595067
58MP0010352_gastrointestinal_tract_polyps1.36591524
59MP0002877_abnormal_melanocyte_morpholog1.36248355
60MP0009785_altered_susceptibility_to1.35594185
61MP0001915_intracranial_hemorrhage1.35438311
62MP0002006_tumorigenesis1.35163513
63MP0001851_eye_inflammation1.34263271
64MP0005464_abnormal_platelet_physiology1.34253216
65MP0000490_abnormal_crypts_of1.33036528
66MP0002723_abnormal_immune_serum1.32872293
67MP0003303_peritoneal_inflammation1.32378962
68MP0003436_decreased_susceptibility_to1.31527093
69MP0002148_abnormal_hypersensitivity_rea1.31166197
70MP0003191_abnormal_cellular_cholesterol1.30487596
71MP0000015_abnormal_ear_pigmentation1.30050772
72MP0000383_abnormal_hair_follicle1.29775370
73MP0000350_abnormal_cell_proliferation1.29671453
74MP0003718_maternal_effect1.27320584
75MP0009278_abnormal_bone_marrow1.27021371
76MP0001905_abnormal_dopamine_level1.26376337
77MP0003866_abnormal_defecation1.22526689
78MP0008877_abnormal_DNA_methylation1.22321745
79MP0005671_abnormal_response_to1.22065853
80MP0004808_abnormal_hematopoietic_stem1.21913290
81MP0000685_abnormal_immune_system1.18651669
82MP0001485_abnormal_pinna_reflex1.18501325
83MP0002452_abnormal_antigen_presenting1.17820998
84MP0003632_abnormal_nervous_system1.16654971
85MP0005076_abnormal_cell_differentiation1.16456029
86MP0003183_abnormal_peptide_metabolism1.14502962
87MP0005451_abnormal_body_composition1.14400575
88MP0001529_abnormal_vocalization1.14141903
89MP0005365_abnormal_bile_salt1.13793308
90MP0010678_abnormal_skin_adnexa1.13673816
91MP0003656_abnormal_erythrocyte_physiolo1.12885360
92MP0000313_abnormal_cell_death1.12227486
93MP0002420_abnormal_adaptive_immunity1.10169765
94MP0001545_abnormal_hematopoietic_system1.09936050
95MP0005397_hematopoietic_system_phenotyp1.09936050
96MP0001819_abnormal_immune_cell1.09359508
97MP0000462_abnormal_digestive_system1.09242665
98MP0009763_increased_sensitivity_to1.09125560
99MP0000858_altered_metastatic_potential1.08165572
100MP0002938_white_spotting1.08105836
101MP0001800_abnormal_humoral_immune1.06708206
102MP0001835_abnormal_antigen_presentation1.06654263
103MP0002638_abnormal_pupillary_reflex1.06583644
104MP0000465_gastrointestinal_hemorrhage1.06576652
105MP0005621_abnormal_cell_physiology1.03841152
106MP0002229_neurodegeneration1.03785415
107MP0004147_increased_porphyrin_level1.01865040
108MP0008260_abnormal_autophagy1.01791000
109MP0005310_abnormal_salivary_gland1.00943342
110MP0002095_abnormal_skin_pigmentation1.00785978
111MP0003631_nervous_system_phenotype0.98197890
112MP0003633_abnormal_nervous_system0.97906849
113MP0002019_abnormal_tumor_incidence0.97477981
114MP0005379_endocrine/exocrine_gland_phen0.96308165
115MP0002933_joint_inflammation0.95975667
116MP0003828_pulmonary_edema0.95738573
117MP0003453_abnormal_keratinocyte_physiol0.95315817
118MP0005384_cellular_phenotype0.94509025
119MP0000569_abnormal_digit_pigmentation0.93694418
120MP0001697_abnormal_embryo_size0.93497093
121MP0000358_abnormal_cell_content/0.91077040
122MP0001533_abnormal_skeleton_physiology0.90557001
123MP0009643_abnormal_urine_homeostasis0.89587986
124MP0008007_abnormal_cellular_replicative0.89483050
125MP0004270_analgesia0.88120293
126MP0003075_altered_response_to0.87583215
127MP0001845_abnormal_inflammatory_respons0.86178225
128MP0005083_abnormal_biliary_tract0.85630029
129MP0002118_abnormal_lipid_homeostasis0.84619191
130MP0004142_abnormal_muscle_tone0.84319722
131MP0000371_diluted_coat_color0.83896432
132MP0000343_altered_response_to0.83838568
133MP0002080_prenatal_lethality0.83245500
134MP0002086_abnormal_extraembryonic_tissu0.82042169
135MP0005167_abnormal_blood-brain_barrier0.81089402
136MP0008469_abnormal_protein_level0.81019959
137MP0002735_abnormal_chemical_nociception0.80218783
138MP0004947_skin_inflammation0.79758673
139MP0001348_abnormal_lacrimal_gland0.79387870
140MP0000566_synostosis0.79188449
141MP0005501_abnormal_skin_physiology0.77690336
142MP0003448_altered_tumor_morphology0.77538912
143MP0001970_abnormal_pain_threshold0.76034365
144MP0005645_abnormal_hypothalamus_physiol0.75785156
145MP0005332_abnormal_amino_acid0.75412706
146MP0009765_abnormal_xenobiotic_induced0.75131604
147MP0002998_abnormal_bone_remodeling0.74547040
148MP0002405_respiratory_system_inflammati0.74430436
149MP0005085_abnormal_gallbladder_physiolo0.74048856
150MP0001853_heart_inflammation0.73985249
151MP0000579_abnormal_nail_morphology0.73904179
152MP0010307_abnormal_tumor_latency0.73884227
153MP0000598_abnormal_liver_morphology0.73437974
154MP0003186_abnormal_redox_activity0.73199893
155MP0002098_abnormal_vibrissa_morphology0.72670810
156MP0002693_abnormal_pancreas_physiology0.71122370
157MP0000716_abnormal_immune_system0.69440943
158MP0004019_abnormal_vitamin_homeostasis0.68860874

Predicted human phenotypes

RankGene SetZ-score
1Increased mean platelet volume (HP:0011877)6.29233081
2Abnormal platelet volume (HP:0011876)6.07894649
3Prolonged bleeding time (HP:0003010)6.07754937
4Menorrhagia (HP:0000132)5.44141098
5Neurofibrillary tangles (HP:0002185)5.32430025
6Petechiae (HP:0000967)5.02456545
7Gingival bleeding (HP:0000225)4.75855051
8Epistaxis (HP:0000421)4.53129325
9Purpura (HP:0000979)4.47774495
10Degeneration of the lateral corticospinal tracts (HP:0002314)4.47514414
11Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.47514414
12Parakeratosis (HP:0001036)4.34458425
13Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)4.22595261
14Stomatitis (HP:0010280)4.04482991
15White forelock (HP:0002211)3.85898263
16Patchy hypopigmentation of hair (HP:0011365)3.82317523
17Acanthocytosis (HP:0001927)3.64997037
18Cerebral inclusion bodies (HP:0100314)3.62566634
19Impaired platelet aggregation (HP:0003540)3.57775718
20Abnormal platelet function (HP:0011869)3.57775718
21Increased IgM level (HP:0003496)3.54799396
22Abnormality of T cell number (HP:0011839)3.47534592
23T lymphocytopenia (HP:0005403)3.46509312
24Abnormality of macrophages (HP:0004311)3.35841751
25Abnormality of the common coagulation pathway (HP:0010990)3.33736386
26Increased neuronal autofluorescent lipopigment (HP:0002074)3.28210801
27Supranuclear gaze palsy (HP:0000605)3.23856935
28Abnormality of the corticospinal tract (HP:0002492)3.23137713
29Vacuolated lymphocytes (HP:0001922)3.22557266
30Increased circulating renin level (HP:0000848)3.13116858
31Recurrent abscess formation (HP:0002722)3.12469024
32Peripheral hypomyelination (HP:0007182)3.10739967
33Segmental peripheral demyelination/remyelination (HP:0003481)3.07912648
34Axonal loss (HP:0003447)3.05503254
35Hyperlipoproteinemia (HP:0010980)2.99657113
36Poikilocytosis (HP:0004447)2.95837460
37Increased cerebral lipofuscin (HP:0011813)2.94154516
38Abnormality of aromatic amino acid family metabolism (HP:0004338)2.88364989
39Recurrent bacterial skin infections (HP:0005406)2.87392640
40Amaurosis fugax (HP:0100576)2.80260911
41Onion bulb formation (HP:0003383)2.79647315
42Slow saccadic eye movements (HP:0000514)2.76183424
43Dysostosis multiplex (HP:0000943)2.71901575
44Hypomagnesemia (HP:0002917)2.69421781
45Upper limb muscle weakness (HP:0003484)2.67892169
46Dyschromatopsia (HP:0007641)2.65535602
47Blue irides (HP:0000635)2.61186060
48Hypokalemic alkalosis (HP:0001949)2.60882015
49Episodic fever (HP:0001954)2.60475150
50Papillary thyroid carcinoma (HP:0002895)2.59941698
51Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.56188192
52Granulocytopenia (HP:0001913)2.54288185
53Abnormality of B cell number (HP:0010975)2.52794792
54Thrombocytosis (HP:0001894)2.52691470
55Metabolic alkalosis (HP:0200114)2.52612347
56Eczematoid dermatitis (HP:0000976)2.50806070
57Spontaneous hematomas (HP:0007420)2.49991045
58Cortical dysplasia (HP:0002539)2.49667385
59Loss of speech (HP:0002371)2.47789154
60Clumsiness (HP:0002312)2.47386765
61Abnormality of T cells (HP:0002843)2.46446448
62Peripheral demyelination (HP:0011096)2.44712771
63Recurrent skin infections (HP:0001581)2.39962878
64Abnormal auditory evoked potentials (HP:0006958)2.38320911
65IgM deficiency (HP:0002850)2.36977210
66Congenital ichthyosiform erythroderma (HP:0007431)2.36639818
67Stomach cancer (HP:0012126)2.34748694
68Hepatosplenomegaly (HP:0001433)2.33979895
69Intrahepatic cholestasis (HP:0001406)2.33094051
70Encephalitis (HP:0002383)2.31123078
71Eosinophilia (HP:0001880)2.29418566
72Retinal dysplasia (HP:0007973)2.26130719
73IgG deficiency (HP:0004315)2.25029667
74Premature skin wrinkling (HP:0100678)2.24001808
75Alacrima (HP:0000522)2.22428535
76Gastrointestinal infarctions (HP:0005244)2.20821091
77Leukocytosis (HP:0001974)2.20757504
78Progressive neurologic deterioration (HP:0002344)2.18675837
79Recurrent viral infections (HP:0004429)2.14694547
80Termporal pattern (HP:0011008)2.14424739
81Insidious onset (HP:0003587)2.14424739
82Anorexia (HP:0002039)2.14231114
83Chronic obstructive pulmonary disease (HP:0006510)2.14050541
84Arterial thrombosis (HP:0004420)2.13574593
85Combined immunodeficiency (HP:0005387)2.13341952
86Conjunctival telangiectasia (HP:0000524)2.13063796
87Hypophosphatemic rickets (HP:0004912)2.10257314
88Sensory axonal neuropathy (HP:0003390)2.08375532
89Severe combined immunodeficiency (HP:0004430)2.07834943
90Elevated erythrocyte sedimentation rate (HP:0003565)2.06990271
91Abnormality of magnesium homeostasis (HP:0004921)2.06280452
92Spastic gait (HP:0002064)2.05742064
93Congenital sensorineural hearing impairment (HP:0008527)2.05360406
94Prolonged neonatal jaundice (HP:0006579)2.05094259
95Joint swelling (HP:0001386)2.01233926
96Hypoplasia of the iris (HP:0007676)2.00846469
97Autoimmune thrombocytopenia (HP:0001973)2.00605317
98Panhypogammaglobulinemia (HP:0003139)1.99508853
99Anhidrosis (HP:0000970)1.99458438
100Spastic diplegia (HP:0001264)1.99242469
101Mucopolysacchariduria (HP:0008155)1.98662130
102Urinary glycosaminoglycan excretion (HP:0003541)1.98662130
103Abnormality of polysaccharide metabolism (HP:0011012)1.96910862
104Abnormality of glycosaminoglycan metabolism (HP:0004371)1.96910862
105Abnormality of mucopolysaccharide metabolism (HP:0011020)1.96910862
106Amyloidosis (HP:0011034)1.96634628
107Abnormality of the vasculature of the conjunctiva (HP:0008054)1.93792546
108Lymphoma (HP:0002665)1.93171181
109Abnormality of liposaccharide metabolism (HP:0010968)1.93137311
110Abnormality of glycosphingolipid metabolism (HP:0004343)1.93137311
111Abnormality of glycolipid metabolism (HP:0010969)1.93137311
112Abnormality of oral frenula (HP:0000190)1.92445494
113Uterine leiomyosarcoma (HP:0002891)1.90710604
114Leiomyosarcoma (HP:0100243)1.90710604
115Cerebral hemorrhage (HP:0001342)1.87170076
116Aplasia/Hypoplasia affecting the retina (HP:0008061)1.86214511
117Decreased lacrimation (HP:0000633)1.84721055
118Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.84695847
119Hypothermia (HP:0002045)1.83719286
120Autoimmune hemolytic anemia (HP:0001890)1.83424237
121Pheochromocytoma (HP:0002666)1.82122989
122Increased density of long bones (HP:0006392)1.82066144
123Aplasia/Hypoplasia of the thymus (HP:0010515)1.81853550
124Ocular albinism (HP:0001107)1.81113921
125Seborrheic dermatitis (HP:0001051)1.80877083
126Autoamputation (HP:0001218)1.80643636
127Abnormal large intestine physiology (HP:0012700)1.78964229
128Abnormality of homocysteine metabolism (HP:0010919)1.77797642
129Homocystinuria (HP:0002156)1.77797642
130Hypercholesterolemia (HP:0003124)1.77077236
131Abnormal delayed hypersensitivity skin test (HP:0002963)1.76223742
132Enlarged epiphyses (HP:0010580)1.76043505
133Paraparesis (HP:0002385)1.75451789
134Thrombophlebitis (HP:0004418)1.74967768
135Erythroderma (HP:0001019)1.74749513
136Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.74645394
137Premature ovarian failure (HP:0008209)1.74613754
138Hypoplastic pelvis (HP:0008839)1.73105537
139Spastic paraparesis (HP:0002313)1.72701615
140Ankyloglossia (HP:0010296)1.71694285
141Pulmonary embolism (HP:0002204)1.71541833
142Transitional cell carcinoma of the bladder (HP:0006740)1.70894871
143Abnormality of renin-angiotensin system (HP:0000847)1.70748833
144Type II lissencephaly (HP:0007260)1.70735149
145Gastrointestinal stroma tumor (HP:0100723)1.68883468
146Hypobetalipoproteinemia (HP:0003563)1.68703973
147Pallor (HP:0000980)1.68197842
148Hypoglycemic seizures (HP:0002173)1.68193201
149Chest pain (HP:0100749)1.68074146
150Tinnitus (HP:0000360)1.68056290
151Abnormality of the prostate (HP:0008775)1.67836502
152Xanthomatosis (HP:0000991)1.67781910
153Meningitis (HP:0001287)1.67573362
154IgA deficiency (HP:0002720)1.66951135
155Inflammation of the large intestine (HP:0002037)1.66735456
156Neuroendocrine neoplasm (HP:0100634)1.66599469
157Gastrointestinal inflammation (HP:0004386)1.66534518
158Supernumerary ribs (HP:0005815)1.66482777
159Opisthotonus (HP:0002179)1.65214817
160Vasculitis (HP:0002633)1.64858350
161Cupped ear (HP:0000378)1.64316636
162Akinesia (HP:0002304)1.63968785
163Absent septum pellucidum (HP:0001331)1.63488886
164Vascular calcification (HP:0004934)1.63382818
165Cerebral hypomyelination (HP:0006808)1.62699246
166Tetany (HP:0001281)1.62665990
167Abnormality of T cell physiology (HP:0011840)1.62363605
168Viral hepatitis (HP:0006562)1.62226342
169Urticaria (HP:0001025)1.62060270
170Myositis (HP:0100614)1.61626915
171Spontaneous abortion (HP:0005268)1.61034640
172Hypoplasia of the thymus (HP:0000778)1.60723005
173Microvesicular hepatic steatosis (HP:0001414)1.60235453
174Aplasia/Hypoplasia of the macula (HP:0008059)1.59341467
175Recurrent fungal infections (HP:0002841)1.58543383
176Abnormality of eosinophils (HP:0001879)1.57732656
177Hypophosphatemia (HP:0002148)1.57228499
178Stridor (HP:0010307)1.56816413
179Retinal atrophy (HP:0001105)1.56726147
180Submucous cleft hard palate (HP:0000176)1.56370568
181Partial agenesis of the corpus callosum (HP:0001338)1.55790424
182Rickets (HP:0002748)1.54391216
183Elevated alkaline phosphatase (HP:0003155)1.54310709
184Obstructive lung disease (HP:0006536)1.52909693

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHB14.72499109
2RIPK44.33375797
3STK394.15136288
4EIF2AK13.58364282
5OXSR12.92613402
6BMPR22.66986798
7MET2.55541212
8MAPKAPK52.55216272
9TAOK32.23880232
10PASK2.21747098
11WNK42.18307809
12SRPK12.03743252
13MAP3K101.99486904
14MAPK151.96646807
15CDK121.92961800
16MST41.89790440
17NTRK11.86202620
18GRK61.82352511
19PBK1.79721176
20SCYL21.75037095
21MAP4K11.75024782
22MAP3K141.62186307
23EPHA31.60817437
24CSNK1A1L1.60620553
25RAF11.59935802
26MST1R1.57174101
27BLK1.56513471
28EEF2K1.49577697
29CSNK1G31.48704612
30TXK1.47019397
31FGR1.46359680
32KSR21.44149163
33PKN11.43193779
34CDK61.42425875
35CLK11.40491123
36INSRR1.38161750
37IRAK41.37938152
38CSNK1G11.33258152
39STK101.31191867
40HIPK21.28908619
41TBK11.26260195
42BRD41.21448601
43BCR1.19809991
44SMG11.19629927
45YES11.18722665
46SIK31.18269411
47ITK1.13878249
48IKBKE1.10365826
49CDC71.10233419
50IRAK11.10126524
51TESK21.09263791
52GSK3A1.09105324
53ALK1.05695325
54CDK41.05217359
55TTK1.03579459
56CAMKK21.00842238
57FGFR21.00807920
58CSNK1G20.99817539
59ZAP700.99541147
60MAP2K30.97096910
61LCK0.97002581
62BTK0.94672902
63UHMK10.94019445
64BMPR1B0.93894762
65MATK0.93615037
66CSK0.92918257
67DYRK20.92372519
68RPS6KB20.91969002
69SGK4940.89492384
70SGK2230.89492384
71RPS6KA50.88390591
72PRKCQ0.88010241
73CAMK1G0.85858813
74KIT0.84376988
75MAP2K20.83797205
76MARK20.83208997
77IKBKB0.82352036
78WNK30.82236984
79WNK10.81918212
80IRAK30.81227281
81PIM10.79268020
82ICK0.78766815
83NEK60.76517254
84FGFR40.75749287
85STK240.74430136
86CAMK2B0.73966053
87MAP3K130.71573688
88CSF1R0.69192152
89TYRO30.67748654
90CAMK2D0.67103575
91MAPKAPK30.64441479
92BMX0.64312478
93JAK10.63740245
94CDK190.63553380
95MARK30.63098336
96PRKCE0.63010181
97EPHA20.62508111
98NLK0.62284843
99FLT30.61451964
100LYN0.61237763
101PTK20.61094994
102STK40.60995974
103TYK20.60991154
104NUAK10.60457284
105TAOK20.60258466
106PDK20.60082475
107TEC0.59736488
108CAMKK10.59547080
109HCK0.59533769
110PAK20.58726709
111JAK30.57899155
112FYN0.57710683
113PAK40.57168091
114MAP3K80.56365827
115PNCK0.55285222
116JAK20.55187373
117DAPK10.53199402
118PIK3CG0.53114961
119MAPK110.53100189
120PDPK10.53063521
121SYK0.52785744
122MUSK0.51167441
123LATS10.50972702
124ARAF0.50716452
125MAP3K90.49832670
126RPS6KA40.49022803
127PDK10.48103438
128IRAK20.47996417
129FES0.47932854
130ILK0.47867663
131GRK70.47833579
132PIM20.47799068
133PDGFRB0.47123830
134TGFBR20.46753033
135INSR0.45882731
136ABL10.45336216
137TNIK0.44120548
138ERN10.43923016
139ADRBK20.43540886
140STK30.42990399
141MAP3K20.42946186
142ERBB40.42875954
143TAOK10.42733107
144RET0.42729357
145ROCK20.42666271
146CDK70.42616743
147IGF1R0.42274821
148PRPF4B0.42270374
149PTK60.42171368
150MAP3K10.42105999
151TRPM70.41977430
152RPS6KB10.40067116
153MAP3K50.40007903
154CDK140.39175183
155CHEK10.38641855
156KSR10.37862978
157MAPKAPK20.36625226
158NEK10.36443152
159TRIM280.33649785
160CSNK2A20.33412798
161EGFR0.32850348
162PAK10.30749410

Predicted pathways (KEGG)

RankGene SetZ-score
1Steroid biosynthesis_Homo sapiens_hsa001004.55558262
2Terpenoid backbone biosynthesis_Homo sapiens_hsa009004.24621452
3Fatty acid elongation_Homo sapiens_hsa000624.05075358
4Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.36971885
5Platelet activation_Homo sapiens_hsa046113.15220034
6Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.86951677
7Protein export_Homo sapiens_hsa030602.79601034
8Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.60230655
9Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.49272783
10Mismatch repair_Homo sapiens_hsa034302.47327957
11Ether lipid metabolism_Homo sapiens_hsa005652.47307593
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.45513446
13Histidine metabolism_Homo sapiens_hsa003402.39636655
14Sulfur metabolism_Homo sapiens_hsa009202.39189407
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.33057248
16Thyroid cancer_Homo sapiens_hsa052162.24869895
17Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.00923762
18Sphingolipid metabolism_Homo sapiens_hsa006002.00142875
19Maturity onset diabetes of the young_Homo sapiens_hsa049501.93503503
20Non-small cell lung cancer_Homo sapiens_hsa052231.92626871
21Shigellosis_Homo sapiens_hsa051311.89292046
22Spliceosome_Homo sapiens_hsa030401.88560337
23Lysosome_Homo sapiens_hsa041421.87333028
24Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.77851417
25DNA replication_Homo sapiens_hsa030301.67439185
26Pancreatic cancer_Homo sapiens_hsa052121.66188013
27Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.63141301
28RNA transport_Homo sapiens_hsa030131.51246628
29SNARE interactions in vesicular transport_Homo sapiens_hsa041301.50149614
30Cell cycle_Homo sapiens_hsa041101.48087265
31Endometrial cancer_Homo sapiens_hsa052131.47835447
32Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.47344232
33Acute myeloid leukemia_Homo sapiens_hsa052211.45492784
34Chronic myeloid leukemia_Homo sapiens_hsa052201.42840452
35Viral carcinogenesis_Homo sapiens_hsa052031.42158890
36Staphylococcus aureus infection_Homo sapiens_hsa051501.34618074
37Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.32439404
38Rheumatoid arthritis_Homo sapiens_hsa053231.28764189
39Hematopoietic cell lineage_Homo sapiens_hsa046401.28724470
40Vitamin digestion and absorption_Homo sapiens_hsa049771.27123595
41Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.25226538
42One carbon pool by folate_Homo sapiens_hsa006701.24425912
43Other glycan degradation_Homo sapiens_hsa005111.19611406
44Ribosome_Homo sapiens_hsa030101.19448506
45Renin-angiotensin system_Homo sapiens_hsa046141.14845268
46Galactose metabolism_Homo sapiens_hsa000521.12344191
47ABC transporters_Homo sapiens_hsa020101.11830694
48alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.10046627
49Folate biosynthesis_Homo sapiens_hsa007901.07957097
50Small cell lung cancer_Homo sapiens_hsa052221.07209957
51Herpes simplex infection_Homo sapiens_hsa051681.06171946
52NF-kappa B signaling pathway_Homo sapiens_hsa040641.05359631
53Autoimmune thyroid disease_Homo sapiens_hsa053201.04924081
54Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.04752767
55Apoptosis_Homo sapiens_hsa042101.04168019
56Butanoate metabolism_Homo sapiens_hsa006501.03282427
57Phagosome_Homo sapiens_hsa041451.02403216
58Malaria_Homo sapiens_hsa051441.01892243
59Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.99620841
60Central carbon metabolism in cancer_Homo sapiens_hsa052300.99131708
61Arginine and proline metabolism_Homo sapiens_hsa003300.99076145
62Colorectal cancer_Homo sapiens_hsa052100.98626554
63Glycosaminoglycan degradation_Homo sapiens_hsa005310.98297630
64Linoleic acid metabolism_Homo sapiens_hsa005910.97452684
65Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.95827722
66Base excision repair_Homo sapiens_hsa034100.93763814
67mRNA surveillance pathway_Homo sapiens_hsa030150.93103858
68Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.92454059
69Graft-versus-host disease_Homo sapiens_hsa053320.92259838
70Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.91835983
71Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.90855542
72Regulation of actin cytoskeleton_Homo sapiens_hsa048100.88435235
73Peroxisome_Homo sapiens_hsa041460.87320801
74Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.86681646
75Osteoclast differentiation_Homo sapiens_hsa043800.86322400
76Drug metabolism - other enzymes_Homo sapiens_hsa009830.86081224
77Phosphatidylinositol signaling system_Homo sapiens_hsa040700.84839229
78Collecting duct acid secretion_Homo sapiens_hsa049660.84069210
79Leishmaniasis_Homo sapiens_hsa051400.83067484
80NOD-like receptor signaling pathway_Homo sapiens_hsa046210.82823441
81Nucleotide excision repair_Homo sapiens_hsa034200.82422774
82Vibrio cholerae infection_Homo sapiens_hsa051100.81936304
83Primary immunodeficiency_Homo sapiens_hsa053400.80562637
84Sphingolipid signaling pathway_Homo sapiens_hsa040710.80133526
85Prostate cancer_Homo sapiens_hsa052150.79512626
86Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.79426230
87Intestinal immune network for IgA production_Homo sapiens_hsa046720.78928908
88Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.78903371
89Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.77879843
90Fatty acid metabolism_Homo sapiens_hsa012120.77743025
91Hepatitis B_Homo sapiens_hsa051610.77204695
92Biosynthesis of amino acids_Homo sapiens_hsa012300.77160017
93Asthma_Homo sapiens_hsa053100.76900732
94Tyrosine metabolism_Homo sapiens_hsa003500.76685900
95Steroid hormone biosynthesis_Homo sapiens_hsa001400.75590234
96Mineral absorption_Homo sapiens_hsa049780.75307919
97Glioma_Homo sapiens_hsa052140.74802037
98Chemokine signaling pathway_Homo sapiens_hsa040620.74132791
99Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.71030872
100Gap junction_Homo sapiens_hsa045400.70574292
101Glutathione metabolism_Homo sapiens_hsa004800.70307973
102N-Glycan biosynthesis_Homo sapiens_hsa005100.67145554
103Arachidonic acid metabolism_Homo sapiens_hsa005900.66685146
104Choline metabolism in cancer_Homo sapiens_hsa052310.66070017
105Renal cell carcinoma_Homo sapiens_hsa052110.65627441
106T cell receptor signaling pathway_Homo sapiens_hsa046600.63154367
107Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.62823994
108Long-term potentiation_Homo sapiens_hsa047200.62666870
109Chemical carcinogenesis_Homo sapiens_hsa052040.62522459
110Systemic lupus erythematosus_Homo sapiens_hsa053220.62027400
111Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.61632706
112Pertussis_Homo sapiens_hsa051330.61580078
113Alcoholism_Homo sapiens_hsa050340.61548485
114Hepatitis C_Homo sapiens_hsa051600.61231446
115Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.61099471
116Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.60539807
117Cysteine and methionine metabolism_Homo sapiens_hsa002700.58747675
118Adherens junction_Homo sapiens_hsa045200.57589404
119Pentose phosphate pathway_Homo sapiens_hsa000300.57258458
120Phospholipase D signaling pathway_Homo sapiens_hsa040720.56648326
121B cell receptor signaling pathway_Homo sapiens_hsa046620.56484483
122Allograft rejection_Homo sapiens_hsa053300.56399765
123Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.56315970
124Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55963248
125Tuberculosis_Homo sapiens_hsa051520.55492762
126Complement and coagulation cascades_Homo sapiens_hsa046100.53692617
127Leukocyte transendothelial migration_Homo sapiens_hsa046700.52931029
128Non-homologous end-joining_Homo sapiens_hsa034500.52578371
129beta-Alanine metabolism_Homo sapiens_hsa004100.51695845
130Toll-like receptor signaling pathway_Homo sapiens_hsa046200.51221912
131Pentose and glucuronate interconversions_Homo sapiens_hsa000400.50971546
132Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.50156143
133Primary bile acid biosynthesis_Homo sapiens_hsa001200.49942642
134Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.49909971
135Inositol phosphate metabolism_Homo sapiens_hsa005620.49531294
136VEGF signaling pathway_Homo sapiens_hsa043700.49326997
137Neurotrophin signaling pathway_Homo sapiens_hsa047220.48872397
138Legionellosis_Homo sapiens_hsa051340.48730554
139Pyrimidine metabolism_Homo sapiens_hsa002400.47942054
140Axon guidance_Homo sapiens_hsa043600.47605926
141Retinol metabolism_Homo sapiens_hsa008300.47391905
142Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.47145193
143Epstein-Barr virus infection_Homo sapiens_hsa051690.46646709
144Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.45399722
145Measles_Homo sapiens_hsa051620.45214556
146Endocytosis_Homo sapiens_hsa041440.44456120
147ErbB signaling pathway_Homo sapiens_hsa040120.43882745
148Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.42715713
149Carbohydrate digestion and absorption_Homo sapiens_hsa049730.42346697
150Influenza A_Homo sapiens_hsa051640.41628844
151African trypanosomiasis_Homo sapiens_hsa051430.41082313
152Oocyte meiosis_Homo sapiens_hsa041140.41021411
153Ras signaling pathway_Homo sapiens_hsa040140.38936077
154Antigen processing and presentation_Homo sapiens_hsa046120.38708117
155Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.38430449
156Melanoma_Homo sapiens_hsa052180.37381943
157Rap1 signaling pathway_Homo sapiens_hsa040150.37317711
158p53 signaling pathway_Homo sapiens_hsa041150.35774924
159Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.34888022
160Glycerophospholipid metabolism_Homo sapiens_hsa005640.34746931
161RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.34709719
162Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.34480823
163TNF signaling pathway_Homo sapiens_hsa046680.34000528
164Toxoplasmosis_Homo sapiens_hsa051450.33533627
165Tryptophan metabolism_Homo sapiens_hsa003800.33387827
166Ovarian steroidogenesis_Homo sapiens_hsa049130.31824630
167Transcriptional misregulation in cancer_Homo sapiens_hsa052020.30919082
168Serotonergic synapse_Homo sapiens_hsa047260.30268915
169Salmonella infection_Homo sapiens_hsa051320.29812556
170Jak-STAT signaling pathway_Homo sapiens_hsa046300.26264245
171Caffeine metabolism_Homo sapiens_hsa002320.24253178
172Bile secretion_Homo sapiens_hsa049760.23839033

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