LRRCC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a centrosomal protein that maintains the structural integrity of the centrosome and plays a key role in mitotic spindle formation. The encoded protein contains an N-terminal leucine-rich repeat domain and a C-terminal coiled-coil domain. It associates with the centrosome throughout the cell cycle and accumulates on the mitotic centrosome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)8.76221343
2fusion of sperm to egg plasma membrane (GO:0007342)7.76985648
3cell wall macromolecule catabolic process (GO:0016998)6.98809778
4cell wall macromolecule metabolic process (GO:0044036)6.98809778
5acrosome assembly (GO:0001675)6.57477196
6multicellular organism reproduction (GO:0032504)6.47719782
7sperm-egg recognition (GO:0035036)6.44842451
8sperm motility (GO:0030317)6.40386512
9axonemal dynein complex assembly (GO:0070286)6.23352686
10epithelial cilium movement (GO:0003351)6.19763329
11plasma membrane fusion (GO:0045026)5.98570677
12binding of sperm to zona pellucida (GO:0007339)5.96756384
13epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.78611426
14cell-cell recognition (GO:0009988)5.78216093
15piRNA metabolic process (GO:0034587)5.64028596
16male meiosis (GO:0007140)5.42875784
17motile cilium assembly (GO:0044458)5.32733219
18acrosome reaction (GO:0007340)5.24083697
19cilium movement (GO:0003341)5.22731521
20reproduction (GO:0000003)5.12160619
21spermatid development (GO:0007286)5.05005325
22microtubule depolymerization (GO:0007019)5.00010090
23DNA double-strand break processing (GO:0000729)4.99605246
24DNA replication-dependent nucleosome organization (GO:0034723)4.95740605
25DNA replication-dependent nucleosome assembly (GO:0006335)4.95740605
26synaptonemal complex organization (GO:0070193)4.52870927
27mitotic sister chromatid cohesion (GO:0007064)4.47578680
28single fertilization (GO:0007338)4.46100313
29synaptonemal complex assembly (GO:0007130)4.41003733
30DNA replication checkpoint (GO:0000076)4.39214350
31sister chromatid segregation (GO:0000819)4.26825359
32definitive hemopoiesis (GO:0060216)4.22841583
33mitotic G2/M transition checkpoint (GO:0044818)4.20927657
34metaphase plate congression (GO:0051310)4.13102308
35regulation of cilium movement (GO:0003352)4.13083642
36replication fork processing (GO:0031297)4.03202631
37mitotic sister chromatid segregation (GO:0000070)4.00918299
38mitotic G2 DNA damage checkpoint (GO:0007095)3.86513357
39regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.85790115
40spermatid nucleus differentiation (GO:0007289)3.81058674
41mitotic metaphase plate congression (GO:0007080)3.76283222
42monoubiquitinated protein deubiquitination (GO:0035520)3.72609833
43DNA methylation involved in gamete generation (GO:0043046)3.70291395
44nuclear pore complex assembly (GO:0051292)3.68654344
45resolution of meiotic recombination intermediates (GO:0000712)3.67940766
46fertilization (GO:0009566)3.65092001
47chromosome organization involved in meiosis (GO:0070192)3.64917812
48maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.62665971
49negative regulation of DNA recombination (GO:0045910)3.61417408
50kinetochore organization (GO:0051383)3.55975923
51establishment of integrated proviral latency (GO:0075713)3.54388093
52sister chromatid cohesion (GO:0007062)3.54246527
53protein localization to kinetochore (GO:0034501)3.51109042
54regulation of mesoderm development (GO:2000380)3.50864697
55centriole replication (GO:0007099)3.50524386
56telomere maintenance via semi-conservative replication (GO:0032201)3.49152390
57DNA damage response, detection of DNA damage (GO:0042769)3.47910072
58ventricular system development (GO:0021591)3.46363689
59regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.44536494
60negative regulation of mitotic sister chromatid separation (GO:2000816)3.43897608
61negative regulation of sister chromatid segregation (GO:0033046)3.43897608
62negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.43897608
63negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.43897608
64negative regulation of mitotic sister chromatid segregation (GO:0033048)3.43897608
65male meiosis I (GO:0007141)3.40943293
66regulation of mitotic metaphase/anaphase transition (GO:0030071)3.40292177
67regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.40292177
68meiotic nuclear division (GO:0007126)3.40220974
69protein localization to cilium (GO:0061512)3.40212826
70establishment of chromosome localization (GO:0051303)3.38407989
71DNA strand elongation involved in DNA replication (GO:0006271)3.37963205
72negative regulation of chromosome segregation (GO:0051985)3.37178061
73DNA ligation (GO:0006266)3.34622338
74sperm capacitation (GO:0048240)3.34368003
75histone mRNA metabolic process (GO:0008334)3.32260670
76spindle checkpoint (GO:0031577)3.31281473
77synapsis (GO:0007129)3.29726774
78somite rostral/caudal axis specification (GO:0032525)3.29400840
79mitotic spindle checkpoint (GO:0071174)3.28625050
80DNA catabolic process, exonucleolytic (GO:0000738)3.27585152
81DNA strand elongation (GO:0022616)3.23433604
82regulation of centriole replication (GO:0046599)3.22319148
83mitotic spindle assembly checkpoint (GO:0007094)3.21166004
84male gamete generation (GO:0048232)3.21148151
85non-recombinational repair (GO:0000726)3.20726118
86double-strand break repair via nonhomologous end joining (GO:0006303)3.20726118
87spermatogenesis (GO:0007283)3.20588173
88regulation of DNA endoreduplication (GO:0032875)3.20491094
89intraciliary transport (GO:0042073)3.19466689
90meiotic chromosome segregation (GO:0045132)3.19029332
91spindle assembly checkpoint (GO:0071173)3.18993370
92meiotic cell cycle (GO:0051321)3.17583788
93regulation of mitotic sister chromatid separation (GO:0010965)3.16267814
94regulation of mitotic sister chromatid segregation (GO:0033047)3.16267814
95regulation of sister chromatid segregation (GO:0033045)3.16267814
96phospholipid scrambling (GO:0017121)3.14403327
97CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.13152802
98histone exchange (GO:0043486)3.12952614
99ATP-dependent chromatin remodeling (GO:0043044)3.11086269
100germ cell development (GO:0007281)3.10316711
101centriole assembly (GO:0098534)3.08996043
102regulation of chromosome segregation (GO:0051983)3.07156024
103proteasome assembly (GO:0043248)3.07022070
104single strand break repair (GO:0000012)3.06584658
105negative regulation of inclusion body assembly (GO:0090084)3.06193060
106regulation of nuclear cell cycle DNA replication (GO:0033262)3.05062805
107purine nucleobase biosynthetic process (GO:0009113)3.04524759
108chromosome segregation (GO:0007059)3.02555077
109positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.02046639
110positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.02046639
111positive regulation of mitotic sister chromatid separation (GO:1901970)3.02046639
112regulation of helicase activity (GO:0051095)3.00945333
113chromatin assembly or disassembly (GO:0006333)3.00037104
114cellular process involved in reproduction in multicellular organism (GO:0022412)2.99495051
115gamete generation (GO:0007276)2.99311711
116cell recognition (GO:0008037)2.98138741
117protein K6-linked ubiquitination (GO:0085020)2.94914324
118postreplication repair (GO:0006301)2.94254491
119seminiferous tubule development (GO:0072520)2.93461173
120DNA-dependent DNA replication (GO:0006261)2.91883956
121double-strand break repair via homologous recombination (GO:0000724)2.90614750
122DNA topological change (GO:0006265)2.89502280
123recombinational repair (GO:0000725)2.88973705
124pore complex assembly (GO:0046931)2.88015906
125regulation of spindle checkpoint (GO:0090231)2.87633526
126genitalia morphogenesis (GO:0035112)2.84096180
127intra-S DNA damage checkpoint (GO:0031573)2.82524670
128DNA packaging (GO:0006323)2.82334653
129DNA unwinding involved in DNA replication (GO:0006268)2.81457603
130microtubule polymerization or depolymerization (GO:0031109)2.81049657
131nuclear pore organization (GO:0006999)2.79754824
132protein localization to chromosome, centromeric region (GO:0071459)2.78527314
133regulation of meiosis I (GO:0060631)2.77063988
134negative regulation of mitosis (GO:0045839)2.77021335
135chromosome condensation (GO:0030261)2.74864181
136regulation of centrosome duplication (GO:0010824)2.74849024
137response to X-ray (GO:0010165)2.74737500
138regulation of penile erection (GO:0060405)2.74224355
139regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.72666668
140regulation of mitotic spindle checkpoint (GO:1903504)2.72666668
141centrosome organization (GO:0051297)2.72175577
142mismatch repair (GO:0006298)2.71729662
143somatic hypermutation of immunoglobulin genes (GO:0016446)2.71080458
144somatic diversification of immune receptors via somatic mutation (GO:0002566)2.71080458
145meiosis I (GO:0007127)2.70375002
146kinetochore assembly (GO:0051382)2.67451787
147protein neddylation (GO:0045116)2.66858019
148primitive streak formation (GO:0090009)2.65193176
149protein K11-linked deubiquitination (GO:0035871)2.65084959
150regulation of DNA-dependent DNA replication (GO:0090329)2.64590493
151chromatin remodeling at centromere (GO:0031055)2.64213155
152base-excision repair (GO:0006284)2.64086574
153DNA replication initiation (GO:0006270)2.61362717
154calcium ion-dependent exocytosis (GO:0017156)2.60460874
155meiotic cell cycle process (GO:1903046)2.59353972
156CENP-A containing nucleosome assembly (GO:0034080)2.59024880
157gene silencing by RNA (GO:0031047)2.58835093
158attachment of spindle microtubules to kinetochore (GO:0008608)2.58396745
159DNA replication-independent nucleosome assembly (GO:0006336)2.56012415
160DNA replication-independent nucleosome organization (GO:0034724)2.56012415
161mitotic chromosome condensation (GO:0007076)2.54498766
162histone H2A acetylation (GO:0043968)2.54366289
163viral mRNA export from host cell nucleus (GO:0046784)2.53675478
164telomere maintenance via recombination (GO:0000722)2.52028833
165negative regulation of DNA repair (GO:0045738)2.51746763
166cilium organization (GO:0044782)2.51417940
167negative regulation of DNA-dependent DNA replication (GO:2000104)2.51171573
168negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.48728082
169mitotic recombination (GO:0006312)2.46348018
170cilium assembly (GO:0042384)2.44332171
171regulation of centrosome cycle (GO:0046605)2.41068066
172nucleotide-excision repair, DNA gap filling (GO:0006297)2.40938706

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse6.06172572
2E2F7_22180533_ChIP-Seq_HELA_Human4.50614835
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.76005892
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.43717635
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.37321345
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.93934178
7EZH2_22144423_ChIP-Seq_EOC_Human2.65470684
8GABP_17652178_ChIP-ChIP_JURKAT_Human2.63504824
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.62839340
10AR_21909140_ChIP-Seq_LNCAP_Human2.59069673
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.51546601
12FLI1_27457419_Chip-Seq_LIVER_Mouse2.49711764
13E2F4_17652178_ChIP-ChIP_JURKAT_Human2.48394942
14MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.46787402
15FUS_26573619_Chip-Seq_HEK293_Human2.30009492
16POU3F2_20337985_ChIP-ChIP_501MEL_Human2.28077917
17PCGF2_27294783_Chip-Seq_ESCs_Mouse2.20459518
18ZFP57_27257070_Chip-Seq_ESCs_Mouse2.19965366
19TAF15_26573619_Chip-Seq_HEK293_Human2.13872593
20SALL1_21062744_ChIP-ChIP_HESCs_Human2.13749006
21CBX2_27304074_Chip-Seq_ESCs_Mouse2.09493618
22SCL_19346495_ChIP-Seq_HPC-7_Human2.04659997
23ZNF274_21170338_ChIP-Seq_K562_Hela2.01311995
24PADI4_21655091_ChIP-ChIP_MCF-7_Human1.99418860
25CREB1_15753290_ChIP-ChIP_HEK293T_Human1.98002626
26CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.89679095
27FOXM1_23109430_ChIP-Seq_U2OS_Human1.86328375
28MYC_18555785_ChIP-Seq_MESCs_Mouse1.84535551
29CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.83656982
30RBPJ_22232070_ChIP-Seq_NCS_Mouse1.79670116
31PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.78759100
32EWS_26573619_Chip-Seq_HEK293_Human1.77777427
33* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.77188613
34TP63_19390658_ChIP-ChIP_HaCaT_Human1.74078493
35FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.72364492
36POU5F1_16153702_ChIP-ChIP_HESCs_Human1.68622448
37FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.68363832
38GBX2_23144817_ChIP-Seq_PC3_Human1.65071553
39RNF2_27304074_Chip-Seq_NSC_Mouse1.61218142
40MYC_18940864_ChIP-ChIP_HL60_Human1.58580509
41RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.57604416
42CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.57470911
43PCGF2_27294783_Chip-Seq_NPCs_Mouse1.55782537
44TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.55689581
45VDR_23849224_ChIP-Seq_CD4+_Human1.51337360
46TAL1_26923725_Chip-Seq_HPCs_Mouse1.50746537
47NANOG_16153702_ChIP-ChIP_HESCs_Human1.48506347
48FOXP3_21729870_ChIP-Seq_TREG_Human1.46187771
49FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.45042462
50E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.44020523
51CTBP2_25329375_ChIP-Seq_LNCAP_Human1.43066690
52KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.42086444
53NANOG_18555785_Chip-Seq_ESCs_Mouse1.40752371
54SUZ12_27294783_Chip-Seq_NPCs_Mouse1.40544500
55PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.40062333
56EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.39751317
57NFE2_27457419_Chip-Seq_LIVER_Mouse1.38608193
58MYC_19030024_ChIP-ChIP_MESCs_Mouse1.37739946
59MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.36704447
60WT1_19549856_ChIP-ChIP_CCG9911_Human1.36499105
61TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35048403
62POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.35048403
63KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.34783119
64GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33081691
65ER_23166858_ChIP-Seq_MCF-7_Human1.31315473
66P300_19829295_ChIP-Seq_ESCs_Human1.30121641
67TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.29331295
68IGF1R_20145208_ChIP-Seq_DFB_Human1.28418335
69CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26252116
70KDM2B_26808549_Chip-Seq_REH_Human1.26129854
71P53_22387025_ChIP-Seq_ESCs_Mouse1.26123413
72YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.24120602
73MYCN_18555785_ChIP-Seq_MESCs_Mouse1.23713491
74HOXB4_20404135_ChIP-ChIP_EML_Mouse1.23028927
75SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.22430209
76CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.22173322
77SOX2_16153702_ChIP-ChIP_HESCs_Human1.22142902
78IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.21975413
79* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.21503124
80EZH2_27294783_Chip-Seq_NPCs_Mouse1.20484282
81CMYC_18555785_Chip-Seq_ESCs_Mouse1.18371477
82ETS1_20019798_ChIP-Seq_JURKAT_Human1.18207936
83JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.17347918
84P300_18555785_Chip-Seq_ESCs_Mouse1.17316001
85E2F1_18555785_Chip-Seq_ESCs_Mouse1.17004645
86NELFA_20434984_ChIP-Seq_ESCs_Mouse1.16818846
87ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.16358572
88SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.16150915
89SUZ12_18555785_Chip-Seq_ESCs_Mouse1.15757587
90IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.14356128
91CBP_20019798_ChIP-Seq_JUKART_Human1.14356128
92* E2F1_21310950_ChIP-Seq_MCF-7_Human1.14304746
93KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.14010182
94KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.14010182
95KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.14010182
96EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.13583962
97OCT4_18555785_Chip-Seq_ESCs_Mouse1.13061200
98STAT3_18555785_Chip-Seq_ESCs_Mouse1.12146854
99POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.09493063
100CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.09210293
101MYC_19079543_ChIP-ChIP_MESCs_Mouse1.07981591
102OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07934924
103ELK1_19687146_ChIP-ChIP_HELA_Human1.07898734
104SOX9_26525672_Chip-Seq_HEART_Mouse1.07546588
105TCF4_23295773_ChIP-Seq_U87_Human1.07137956
106TTF2_22483619_ChIP-Seq_HELA_Human1.06947185
107SMAD4_21799915_ChIP-Seq_A2780_Human1.05584212
108ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.04823479
109PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04807861
110AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.04659888
111CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.04621812
112SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04093759
113FLI1_21867929_ChIP-Seq_TH2_Mouse1.03495042
114GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.03220135
115DCP1A_22483619_ChIP-Seq_HELA_Human1.02658461
116* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.02345869
117SMAD3_21741376_ChIP-Seq_EPCs_Human1.02119981
118* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.01549939
119NMYC_18555785_Chip-Seq_ESCs_Mouse1.01143878
120HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.00975240
121STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.99627139
122CRX_20693478_ChIP-Seq_RETINA_Mouse0.98437782
123MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.98053189
124UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.97511602
125TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97074765
126MYC_18358816_ChIP-ChIP_MESCs_Mouse0.96080595
127TOP2B_26459242_ChIP-Seq_MCF-7_Human0.95142716
128BCAT_22108803_ChIP-Seq_LS180_Human0.95067261
129SOX2_19829295_ChIP-Seq_ESCs_Human0.94037566
130NANOG_19829295_ChIP-Seq_ESCs_Human0.94037566
131KLF4_18555785_Chip-Seq_ESCs_Mouse0.93045009
132MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.92997332
133* SOX2_18555785_Chip-Seq_ESCs_Mouse0.92540475
134GATA1_26923725_Chip-Seq_HPCs_Mouse0.92468265
135VDR_22108803_ChIP-Seq_LS180_Human0.91817768
136IRF1_19129219_ChIP-ChIP_H3396_Human0.91797270
137ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.90735447
138GABP_19822575_ChIP-Seq_HepG2_Human0.89775824
139* BMI1_23680149_ChIP-Seq_NPCS_Mouse0.89638256
140SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.89569760
141TCF4_22108803_ChIP-Seq_LS180_Human0.89426978
142CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.89313705
143RUNX1_27457419_Chip-Seq_LIVER_Mouse0.88346991
144SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.87911839
145KAP1_22055183_ChIP-Seq_ESCs_Mouse0.87460470
146LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.87304642
147MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.86732187
148CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.86520498
149CTCF_18555785_Chip-Seq_ESCs_Mouse0.86176396
150* PIAS1_25552417_ChIP-Seq_VCAP_Human0.85875901
151SMAD4_21741376_ChIP-Seq_EPCs_Human0.85447561
152RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.84031656

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization6.58030481
2MP0008877_abnormal_DNA_methylation4.80698052
3MP0000569_abnormal_digit_pigmentation3.61987373
4MP0008057_abnormal_DNA_replication3.32244272
5MP0003698_abnormal_male_reproductive3.16693326
6MP0001929_abnormal_gametogenesis3.10382424
7MP0010094_abnormal_chromosome_stability3.08756434
8MP0008058_abnormal_DNA_repair2.92985665
9MP0003787_abnormal_imprinting2.78184265
10MP0001529_abnormal_vocalization2.77968431
11MP0002396_abnormal_hematopoietic_system2.69837395
12MP0002210_abnormal_sex_determination2.53899655
13MP0004808_abnormal_hematopoietic_stem2.30569387
14MP0003121_genomic_imprinting2.19134253
15MP0001145_abnormal_male_reproductive2.05131602
16MP0003941_abnormal_skin_development2.00556712
17MP0003119_abnormal_digestive_system2.00067437
18MP0005174_abnormal_tail_pigmentation1.98319260
19MP0001188_hyperpigmentation1.98057337
20MP0008007_abnormal_cellular_replicative1.93481333
21MP0002736_abnormal_nociception_after1.91105967
22MP0006072_abnormal_retinal_apoptosis1.89766109
23MP0008004_abnormal_stomach_pH1.87810844
24MP0002938_white_spotting1.86779098
25MP0000653_abnormal_sex_gland1.84058834
26MP0004147_increased_porphyrin_level1.83263514
27MP0003718_maternal_effect1.82298080
28MP0002132_abnormal_respiratory_system1.81490452
29MP0002102_abnormal_ear_morphology1.78448004
30MP0001984_abnormal_olfaction1.76664544
31MP0006292_abnormal_olfactory_placode1.73298187
32MP0002161_abnormal_fertility/fecundity1.67963754
33MP0000015_abnormal_ear_pigmentation1.64645094
34MP0003136_yellow_coat_color1.64336248
35MP0005623_abnormal_meninges_morphology1.63054069
36MP0003077_abnormal_cell_cycle1.59140620
37MP0002095_abnormal_skin_pigmentation1.56018152
38MP0003111_abnormal_nucleus_morphology1.55062926
39MP0005499_abnormal_olfactory_system1.48279426
40MP0005394_taste/olfaction_phenotype1.48279426
41MP0002084_abnormal_developmental_patter1.45045648
42MP0008789_abnormal_olfactory_epithelium1.44923083
43MP0005409_darkened_coat_color1.44298841
44MP0005380_embryogenesis_phenotype1.41446123
45MP0001672_abnormal_embryogenesis/_devel1.41446123
46MP0002233_abnormal_nose_morphology1.41022909
47MP0001286_abnormal_eye_development1.40468484
48MP0002254_reproductive_system_inflammat1.38066876
49MP0003123_paternal_imprinting1.33702097
50MP0003122_maternal_imprinting1.33376920
51MP0006054_spinal_hemorrhage1.30983213
52MP0001485_abnormal_pinna_reflex1.28304042
53MP0002282_abnormal_trachea_morphology1.25546791
54MP0002111_abnormal_tail_morphology1.25381276
55MP0002085_abnormal_embryonic_tissue1.24261472
56MP0001697_abnormal_embryo_size1.17171539
57MP0010030_abnormal_orbit_morphology1.15082524
58MP0005253_abnormal_eye_physiology1.11772788
59MP0003984_embryonic_growth_retardation1.11466121
60MP0002088_abnormal_embryonic_growth/wei1.10877415
61MP0003943_abnormal_hepatobiliary_system1.09440892
62MP0002160_abnormal_reproductive_system1.07242294
63MP0005646_abnormal_pituitary_gland1.05586665
64MP0009697_abnormal_copulation1.04665861
65MP0009379_abnormal_foot_pigmentation1.04571572
66MP0009703_decreased_birth_body1.04366726
67MP0003567_abnormal_fetal_cardiomyocyte1.03243916
68MP0001730_embryonic_growth_arrest1.02411676
69MP0003186_abnormal_redox_activity1.01948712
70MP0004133_heterotaxia1.01819852
71MP0001293_anophthalmia1.00990994
72MP0000372_irregular_coat_pigmentation0.99548631
73MP0001835_abnormal_antigen_presentation0.97937536
74MP0003763_abnormal_thymus_physiology0.97439605
75MP0000703_abnormal_thymus_morphology0.94756019
76MP0002080_prenatal_lethality0.94414871
77MP0000516_abnormal_urinary_system0.93819775
78MP0005367_renal/urinary_system_phenotyp0.93819775
79MP0004957_abnormal_blastocyst_morpholog0.93792435
80MP0004215_abnormal_myocardial_fiber0.93791312
81MP0005551_abnormal_eye_electrophysiolog0.91607144
82MP0002398_abnormal_bone_marrow0.90580126
83MP0002697_abnormal_eye_size0.89892839
84MP0004197_abnormal_fetal_growth/weight/0.88906476
85MP0010307_abnormal_tumor_latency0.88058346
86MP0003755_abnormal_palate_morphology0.87471798
87MP0005391_vision/eye_phenotype0.86865230
88MP0004233_abnormal_muscle_weight0.86403847
89MP0003693_abnormal_embryo_hatching0.85734541
90MP0003880_abnormal_central_pattern0.85440963
91MP0005075_abnormal_melanosome_morpholog0.85379568
92MP0001177_atelectasis0.84567941
93MP0000358_abnormal_cell_content/0.82578321
94MP0005389_reproductive_system_phenotype0.82482580
95MP0003935_abnormal_craniofacial_develop0.81912825
96MP0006035_abnormal_mitochondrial_morpho0.81811394
97MP0005671_abnormal_response_to0.81798593
98MP0005187_abnormal_penis_morphology0.81631795
99MP0005171_absent_coat_pigmentation0.81240456
100MP0002751_abnormal_autonomic_nervous0.80688912
101MP0000647_abnormal_sebaceous_gland0.80290906
102MP0001968_abnormal_touch/_nociception0.79669226
103MP0009250_abnormal_appendicular_skeleto0.78614020
104MP0000428_abnormal_craniofacial_morphol0.78093019
105MP0003937_abnormal_limbs/digits/tail_de0.77936217
106MP0000490_abnormal_crypts_of0.77661956
107MP0000427_abnormal_hair_cycle0.77357724
108MP0005397_hematopoietic_system_phenotyp0.77195497
109MP0001545_abnormal_hematopoietic_system0.77195497
110MP0003936_abnormal_reproductive_system0.77083479
111MP0001119_abnormal_female_reproductive0.76681835
112MP0009672_abnormal_birth_weight0.76368389
113MP0003786_premature_aging0.76295235
114MP0005084_abnormal_gallbladder_morpholo0.75709768
115MP0002009_preneoplasia0.74619363
116MP0000465_gastrointestinal_hemorrhage0.74192400
117MP0002177_abnormal_outer_ear0.73565881
118MP0000383_abnormal_hair_follicle0.73330210
119MP0000462_abnormal_digestive_system0.72623928
120MP0003942_abnormal_urinary_system0.72405503
121MP0004885_abnormal_endolymph0.72289931
122MP0002234_abnormal_pharynx_morphology0.72135979
123MP0008872_abnormal_physiological_respon0.69437032
124MP0003315_abnormal_perineum_morphology0.67725873
125MP0003115_abnormal_respiratory_system0.66419207
126MP0002928_abnormal_bile_duct0.65688942
127MP0002163_abnormal_gland_morphology0.64986156
128MP0001905_abnormal_dopamine_level0.64625679
129MP0003279_aneurysm0.64244655
130MP0002114_abnormal_axial_skeleton0.63478616
131MP0000049_abnormal_middle_ear0.63423880
132MP0005423_abnormal_somatic_nervous0.63306179
133MP0008932_abnormal_embryonic_tissue0.62738930
134MP0000689_abnormal_spleen_morphology0.62577111
135MP0003385_abnormal_body_wall0.61937463
136MP0008995_early_reproductive_senescence0.61810272
137MP0005503_abnormal_tendon_morphology0.60544698
138MP0001879_abnormal_lymphatic_vessel0.60367538
139MP0000716_abnormal_immune_system0.60316722
140MP0000313_abnormal_cell_death0.59824121
141MP0000631_abnormal_neuroendocrine_gland0.58875202
142MP0002166_altered_tumor_susceptibility0.57747519
143MP0002109_abnormal_limb_morphology0.57683291
144MP0000681_abnormal_thyroid_gland0.56408394
145MP0002429_abnormal_blood_cell0.55097091
146MP0000432_abnormal_head_morphology0.54221374
147MP0002420_abnormal_adaptive_immunity0.53971345
148MP0002249_abnormal_larynx_morphology0.53654856
149MP0002722_abnormal_immune_system0.53549677
150MP0005645_abnormal_hypothalamus_physiol0.52942747
151MP0003861_abnormal_nervous_system0.52016462
152MP0004134_abnormal_chest_morphology0.51120822
153MP0002405_respiratory_system_inflammati0.51098714
154MP0001819_abnormal_immune_cell0.50958678
155MP0002133_abnormal_respiratory_system0.50578319
156MP0005388_respiratory_system_phenotype0.50578319
157MP0001919_abnormal_reproductive_system0.50481828
158MP0003890_abnormal_embryonic-extraembry0.49949790
159MP0000350_abnormal_cell_proliferation0.48883904

Predicted human phenotypes

RankGene SetZ-score
1Absent/shortened dynein arms (HP:0200106)8.39569455
2Dynein arm defect of respiratory motile cilia (HP:0012255)8.39569455
3Respiratory insufficiency due to defective ciliary clearance (HP:0200073)8.09293959
4Abnormal respiratory epithelium morphology (HP:0012253)6.06642324
5Abnormal respiratory motile cilium morphology (HP:0005938)6.06642324
6Abnormal respiratory motile cilium physiology (HP:0012261)5.87036745
7Abnormal ciliary motility (HP:0012262)5.19733795
8Rhinitis (HP:0012384)4.74085076
9Nephronophthisis (HP:0000090)3.99883958
10Chronic bronchitis (HP:0004469)3.96307069
11Volvulus (HP:0002580)3.38742661
12Tubulointerstitial nephritis (HP:0001970)3.32263108
13Absent frontal sinuses (HP:0002688)3.24876767
14Abnormality of the renal medulla (HP:0100957)3.19893105
15Infertility (HP:0000789)3.18790204
16Cortical dysplasia (HP:0002539)3.15410795
17Bronchiectasis (HP:0002110)3.13300585
18Nasal polyposis (HP:0100582)3.03260123
19Colon cancer (HP:0003003)3.00608021
20Molar tooth sign on MRI (HP:0002419)3.00032406
21Abnormality of midbrain morphology (HP:0002418)3.00032406
22Bronchitis (HP:0012387)2.99040746
23Chromsome breakage (HP:0040012)2.94449405
24Chromosomal breakage induced by crosslinking agents (HP:0003221)2.64798877
25Abnormality of the labia minora (HP:0012880)2.64048893
26Medial flaring of the eyebrow (HP:0010747)2.61568644
27Pancreatic fibrosis (HP:0100732)2.58523857
28Embryonal renal neoplasm (HP:0011794)2.57890663
29Recurrent sinusitis (HP:0011108)2.56689500
30Postaxial foot polydactyly (HP:0001830)2.52747046
31Medulloblastoma (HP:0002885)2.49856575
32Nephroblastoma (Wilms tumor) (HP:0002667)2.49204059
33Abnormality of the duodenum (HP:0002246)2.47600346
34Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.46997954
35Supernumerary spleens (HP:0009799)2.46565445
36Septo-optic dysplasia (HP:0100842)2.41606281
37Acute myeloid leukemia (HP:0004808)2.41066926
38Rhabdomyosarcoma (HP:0002859)2.40612477
39Abnormality of the nasal mucosa (HP:0000433)2.39376375
40Bifid tongue (HP:0010297)2.37437061
41Recurrent bronchitis (HP:0002837)2.34196531
42Abnormal umbilical cord blood vessels (HP:0011403)2.31923528
43Single umbilical artery (HP:0001195)2.31923528
44Abnormality of the fetal cardiovascular system (HP:0010948)2.31923528
45Triphalangeal thumb (HP:0001199)2.30590064
46Abnormal spermatogenesis (HP:0008669)2.30300972
47Renal dysplasia (HP:0000110)2.27689728
48Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.27020675
49Carpal bone hypoplasia (HP:0001498)2.26576258
50Tubular atrophy (HP:0000092)2.26152629
51Abnormality of chromosome stability (HP:0003220)2.25558021
52Fibular hypoplasia (HP:0003038)2.24639067
53Oligodactyly (hands) (HP:0001180)2.24445201
54Abnormality of the heme biosynthetic pathway (HP:0010472)2.22520392
55Intestinal atresia (HP:0011100)2.14725791
56Irregular epiphyses (HP:0010582)2.11838251
57Small hand (HP:0200055)2.09016762
58Aplasia/Hypoplasia of the uvula (HP:0010293)2.07758191
59Abnormality of methionine metabolism (HP:0010901)2.05901136
6011 pairs of ribs (HP:0000878)2.05626759
61Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.05410469
62Gonadotropin excess (HP:0000837)2.02081935
63Abnormality of the frontal sinuses (HP:0002687)2.00775426
64True hermaphroditism (HP:0010459)2.00475547
65Hyperglycinuria (HP:0003108)2.00130987
66Myelodysplasia (HP:0002863)2.00056827
67Microglossia (HP:0000171)1.97675061
68Acute encephalopathy (HP:0006846)1.97206028
69Ependymoma (HP:0002888)1.94188731
70Abnormality of the preputium (HP:0100587)1.94140814
71Birth length less than 3rd percentile (HP:0003561)1.93469733
72Aplasia/Hypoplasia of the tongue (HP:0010295)1.92912234
73Recurrent otitis media (HP:0000403)1.92240196
74Rectovaginal fistula (HP:0000143)1.92021631
75Rectal fistula (HP:0100590)1.92021631
76Papillary thyroid carcinoma (HP:0002895)1.91527232
77Absent radius (HP:0003974)1.91065443
78Clubbing of toes (HP:0100760)1.89845233
79Syringomyelia (HP:0003396)1.88976281
80Spinal cord lesions (HP:0100561)1.88976281
81Meckel diverticulum (HP:0002245)1.88467898
82Hyperglycinemia (HP:0002154)1.88309883
83Proximal placement of thumb (HP:0009623)1.88023308
84Optic nerve hypoplasia (HP:0000609)1.87423732
85Tubulointerstitial abnormality (HP:0001969)1.86811096
86Gait imbalance (HP:0002141)1.85355692
87Congenital primary aphakia (HP:0007707)1.85211162
88Acute necrotizing encephalopathy (HP:0006965)1.83908108
89Glioma (HP:0009733)1.83167860
90Abnormality of aspartate family amino acid metabolism (HP:0010899)1.82701501
91Anophthalmia (HP:0000528)1.81448462
92Biliary tract neoplasm (HP:0100574)1.81079334
93Aplasia involving forearm bones (HP:0009822)1.79809287
94Absent forearm bone (HP:0003953)1.79809287
95Chronic sinusitis (HP:0011109)1.79171644
96Hemivertebrae (HP:0002937)1.78122793
97Metaphyseal dysplasia (HP:0100255)1.77576026
98Abnormality of the ileum (HP:0001549)1.77346297
99Preaxial hand polydactyly (HP:0001177)1.77130065
100Increased nuchal translucency (HP:0010880)1.76893478
101Pancreatic cysts (HP:0001737)1.76861272
102Ectopic kidney (HP:0000086)1.74160694
103Aplasia/Hypoplasia of the sternum (HP:0006714)1.73997893
104Abnormality of DNA repair (HP:0003254)1.73589964
105Sloping forehead (HP:0000340)1.73103794
106Short middle phalanx of the 5th finger (HP:0004220)1.72718719
107Short ribs (HP:0000773)1.72437913
108Thyroid carcinoma (HP:0002890)1.71888900
109Postaxial hand polydactyly (HP:0001162)1.71649201
110Choanal atresia (HP:0000453)1.71165462
111Abnormality of serine family amino acid metabolism (HP:0010894)1.71024034
112Abnormality of glycine metabolism (HP:0010895)1.71024034
113Duodenal stenosis (HP:0100867)1.70858828
114Small intestinal stenosis (HP:0012848)1.70858828
115Renal hypoplasia (HP:0000089)1.69630771
116Facial cleft (HP:0002006)1.69284918
117Genital tract atresia (HP:0001827)1.68494297
118Aplasia/Hypoplasia of the tibia (HP:0005772)1.68490337
119Anal atresia (HP:0002023)1.68322835
120Abolished electroretinogram (ERG) (HP:0000550)1.67883825
121Methylmalonic acidemia (HP:0002912)1.67858680
122Median cleft lip (HP:0000161)1.67849512
123Anal stenosis (HP:0002025)1.67347317
124Renal agenesis (HP:0000104)1.66318158
125Impulsivity (HP:0100710)1.66025987
126Pancreatic islet-cell hyperplasia (HP:0004510)1.65856044
127Neoplasm of the colon (HP:0100273)1.65641183
128Renal cortical cysts (HP:0000803)1.65633104
129Deviation of the thumb (HP:0009603)1.64704349
130Short 4th metacarpal (HP:0010044)1.64104023
131Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.64104023
132Abnormality of the fovea (HP:0000493)1.63845909
133Astigmatism (HP:0000483)1.63614157
134Stage 5 chronic kidney disease (HP:0003774)1.63404539
135Neoplasm of the oral cavity (HP:0100649)1.63005348
136Neoplasm of the small intestine (HP:0100833)1.61967636
137Nephrogenic diabetes insipidus (HP:0009806)1.61811730
138Abnormality of the renal collecting system (HP:0004742)1.61591247
139Acanthocytosis (HP:0001927)1.61130319
140Abnormality of the prostate (HP:0008775)1.60750900
141Short tibia (HP:0005736)1.59879963
142Abnormal lung lobation (HP:0002101)1.59147769
143Reticulocytopenia (HP:0001896)1.57170165
144Abnormality of the renal cortex (HP:0011035)1.56812284
145Anencephaly (HP:0002323)1.56649515
146Abnormality of the carotid arteries (HP:0005344)1.55451798
147Thrombocytosis (HP:0001894)1.54032481
148Aplastic anemia (HP:0001915)1.53326812
149Poor coordination (HP:0002370)1.51677191
150Prostate neoplasm (HP:0100787)1.51270411
151Abnormal hair whorl (HP:0010721)1.50193162
152Embryonal neoplasm (HP:0002898)1.50065928
153Congenital hepatic fibrosis (HP:0002612)1.49397996
154Chronic hepatic failure (HP:0100626)1.48982189
155Vaginal atresia (HP:0000148)1.48953526
156Acute lymphatic leukemia (HP:0006721)1.47806082
157Aplasia/Hypoplasia of the lens (HP:0008063)1.46680671
158Aplasia/Hypoplasia of the fibula (HP:0006492)1.45992724

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK45.78845862
2PDK35.78845862
3MST43.75085388
4MKNK13.39041788
5MKNK23.15783419
6PDK23.11753196
7PBK3.05887226
8CDC72.98700774
9NEK12.67680041
10PNCK2.19380568
11EIF2AK12.18179826
12NEK22.03660464
13TRIM282.03340735
14BRSK21.94237778
15TNIK1.77035943
16TAF11.76326716
17ERBB41.73227632
18WEE11.70212796
19ATR1.53429599
20MUSK1.53415577
21CCNB11.52697806
22SRPK11.51609182
23VRK11.47350773
24YES11.44916490
25PIK3CA1.41643524
26MAPK131.38347737
27TLK11.37487894
28BMPR1B1.36986674
29PASK1.36955210
30VRK21.36470650
31MAPKAPK51.33977971
32DYRK31.31873779
33TEC1.29267048
34CHEK21.28009125
35LATS11.27781097
36PLK41.26160972
37PTK2B1.25749529
38STK161.25285213
39TGFBR11.22873591
40CDK81.20852315
41CASK1.20332855
42NEK61.17457721
43FRK1.08034619
44STK391.06694758
45PLK31.06627405
46CDK31.06118317
47JAK31.04313743
48ATM1.01442499
49CAMK1G0.99880332
50NUAK10.99674931
51WNK10.99435261
52DMPK0.97278634
53TIE10.97061306
54MAP4K20.95682425
55CHEK10.93746703
56CDK90.92771993
57STK38L0.89696267
58KIT0.89461930
59ERBB30.88499389
60BTK0.87813280
61PLK10.87599674
62MAP2K70.86637166
63MAP3K40.85287827
64BCR0.84066639
65TXK0.76277299
66BUB10.75118815
67CDK60.72866671
68AURKB0.71015238
69ZAK0.69273541
70ITK0.68589177
71OXSR10.64400887
72ICK0.63941739
73RIPK40.60810130
74SIK30.60220478
75EPHA40.59734863
76WNK40.59533120
77RPS6KB10.57810937
78TESK10.56697844
79NTRK30.56565108
80STK30.56327335
81CSF1R0.56255634
82BRSK10.53920528
83EIF2AK20.53777773
84ACVR1B0.53037642
85SIK20.52343321
86BRD40.51596134
87RAF10.51075665
88STK100.50621256
89CSNK1G10.49528897
90FLT30.49493643
91INSRR0.49158637
92DYRK20.49070337
93CLK10.48649191
94PLK20.48558033
95CDK10.46968289
96SCYL20.45664438
97IRAK40.45605876
98CDK70.45587618
99NTRK20.45071841
100MELK0.44165058
101TRPM70.43862154
102CSNK1G20.42667613
103NLK0.42647511
104TSSK60.42624123
105CDK20.42606599
106CSNK1E0.42022970
107BMPR20.39503862
108TTK0.39291397
109IRAK10.39227866
110RPS6KA40.36008967
111RPS6KB20.34836450
112MAPK140.34209819
113EIF2AK30.34209559
114MINK10.34100456
115MAPK150.33691186
116WNK30.32851261
117SGK20.32591356
118PRKDC0.31984685
119PKN10.31721407
120MARK30.31667631
121CSNK1G30.31460151
122SYK0.31050596
123CSNK2A10.30794682
124CSNK2A20.30024356
125RPS6KA50.29624882
126STK40.29125646
127BRAF0.28516163
128CAMK1D0.28013323
129CSNK1A1L0.27411052
130AURKA0.27085198
131MAPK80.26787244
132LCK0.26774681
133NME10.25934902
134FGFR10.25854191
135ROCK10.25615312
136STK240.23695238
137MAP3K80.23158415
138CDK180.21437604
139ERBB20.18675703

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034302.88248735
2DNA replication_Homo sapiens_hsa030302.75199339
3Basal transcription factors_Homo sapiens_hsa030222.72591245
4Fanconi anemia pathway_Homo sapiens_hsa034602.68509352
5Non-homologous end-joining_Homo sapiens_hsa034502.58549945
6Homologous recombination_Homo sapiens_hsa034402.37309909
7Cell cycle_Homo sapiens_hsa041102.29053607
8Base excision repair_Homo sapiens_hsa034102.21764623
9RNA degradation_Homo sapiens_hsa030182.10528370
10Spliceosome_Homo sapiens_hsa030402.00952792
11Nucleotide excision repair_Homo sapiens_hsa034201.96850528
12Propanoate metabolism_Homo sapiens_hsa006401.84619207
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.78422098
14RNA transport_Homo sapiens_hsa030131.77647146
15Steroid biosynthesis_Homo sapiens_hsa001001.77375941
16One carbon pool by folate_Homo sapiens_hsa006701.76430149
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.73174173
18Oocyte meiosis_Homo sapiens_hsa041141.70218529
19Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.64893027
20mRNA surveillance pathway_Homo sapiens_hsa030151.61993426
21Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.51538541
22Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.43044972
23Pyruvate metabolism_Homo sapiens_hsa006201.40312464
24Transcriptional misregulation in cancer_Homo sapiens_hsa052021.38833021
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.31210990
26Cysteine and methionine metabolism_Homo sapiens_hsa002701.29987169
27Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.27356738
28Antigen processing and presentation_Homo sapiens_hsa046121.23784939
29Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.22709903
30Parkinsons disease_Homo sapiens_hsa050121.19449556
31Oxidative phosphorylation_Homo sapiens_hsa001901.17808196
32Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.16841846
33Fatty acid elongation_Homo sapiens_hsa000621.12640263
342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.11347199
35p53 signaling pathway_Homo sapiens_hsa041151.11253917
36Butanoate metabolism_Homo sapiens_hsa006501.11056254
37Ribosome_Homo sapiens_hsa030101.09831534
38Herpes simplex infection_Homo sapiens_hsa051681.07416304
39Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.06467257
40Systemic lupus erythematosus_Homo sapiens_hsa053221.06406199
41Measles_Homo sapiens_hsa051621.04325171
42Allograft rejection_Homo sapiens_hsa053301.03955305
43Amphetamine addiction_Homo sapiens_hsa050311.03412228
44Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.03059302
45Primary immunodeficiency_Homo sapiens_hsa053400.99232208
46Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.98794741
47Ether lipid metabolism_Homo sapiens_hsa005650.98370886
48Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.97121388
49Fatty acid metabolism_Homo sapiens_hsa012120.95673443
50Purine metabolism_Homo sapiens_hsa002300.94692876
51Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.90532294
52Long-term potentiation_Homo sapiens_hsa047200.89857291
53Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.89257680
54Glucagon signaling pathway_Homo sapiens_hsa049220.88986018
55Glutathione metabolism_Homo sapiens_hsa004800.88426319
56Renin secretion_Homo sapiens_hsa049240.85877194
57Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.85665818
58NOD-like receptor signaling pathway_Homo sapiens_hsa046210.85460568
59Nicotine addiction_Homo sapiens_hsa050330.80741841
60Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.80706723
61Pyrimidine metabolism_Homo sapiens_hsa002400.79182367
62Epstein-Barr virus infection_Homo sapiens_hsa051690.79102266
63Caffeine metabolism_Homo sapiens_hsa002320.79056863
64Hematopoietic cell lineage_Homo sapiens_hsa046400.78376416
65Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.77717652
66B cell receptor signaling pathway_Homo sapiens_hsa046620.77077661
67Graft-versus-host disease_Homo sapiens_hsa053320.76711614
68Viral carcinogenesis_Homo sapiens_hsa052030.76277939
69Alcoholism_Homo sapiens_hsa050340.75988347
70Selenocompound metabolism_Homo sapiens_hsa004500.74846302
71Basal cell carcinoma_Homo sapiens_hsa052170.71955097
72Platelet activation_Homo sapiens_hsa046110.71680201
73Glycosaminoglycan degradation_Homo sapiens_hsa005310.71393120
74Glutamatergic synapse_Homo sapiens_hsa047240.69876807
75Fatty acid degradation_Homo sapiens_hsa000710.68974888
76Calcium signaling pathway_Homo sapiens_hsa040200.68964733
77Legionellosis_Homo sapiens_hsa051340.68961012
78Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.68576232
79Protein export_Homo sapiens_hsa030600.67355266
80Autoimmune thyroid disease_Homo sapiens_hsa053200.66861659
81Retinol metabolism_Homo sapiens_hsa008300.66439048
82Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.66226024
83HTLV-I infection_Homo sapiens_hsa051660.66071145
84SNARE interactions in vesicular transport_Homo sapiens_hsa041300.66067798
85Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.65621340
86N-Glycan biosynthesis_Homo sapiens_hsa005100.64716206
87Circadian entrainment_Homo sapiens_hsa047130.63537656
88Hepatitis B_Homo sapiens_hsa051610.63496289
89Influenza A_Homo sapiens_hsa051640.63379199
90Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.62150803
91Huntingtons disease_Homo sapiens_hsa050160.61659402
92Hedgehog signaling pathway_Homo sapiens_hsa043400.61652765
93Salmonella infection_Homo sapiens_hsa051320.60262618
94Vitamin digestion and absorption_Homo sapiens_hsa049770.60220040
95Small cell lung cancer_Homo sapiens_hsa052220.60174620
96Hippo signaling pathway_Homo sapiens_hsa043900.59955675
97Peroxisome_Homo sapiens_hsa041460.59911884
98Olfactory transduction_Homo sapiens_hsa047400.59839093
99Taste transduction_Homo sapiens_hsa047420.59700908
100Jak-STAT signaling pathway_Homo sapiens_hsa046300.59505652
101MicroRNAs in cancer_Homo sapiens_hsa052060.59310597
102Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.58820581
103TGF-beta signaling pathway_Homo sapiens_hsa043500.57623173
104Nitrogen metabolism_Homo sapiens_hsa009100.56081977
105Serotonergic synapse_Homo sapiens_hsa047260.55572531
106Metabolic pathways_Homo sapiens_hsa011000.54154886
107Pentose and glucuronate interconversions_Homo sapiens_hsa000400.54016241
108Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.53454977
109Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.53093365
110Intestinal immune network for IgA production_Homo sapiens_hsa046720.52955121
111Folate biosynthesis_Homo sapiens_hsa007900.50945639
112Shigellosis_Homo sapiens_hsa051310.48922958
113Prostate cancer_Homo sapiens_hsa052150.48686342
114Long-term depression_Homo sapiens_hsa047300.48441287
115cAMP signaling pathway_Homo sapiens_hsa040240.48258511
116Alzheimers disease_Homo sapiens_hsa050100.48126137
117Wnt signaling pathway_Homo sapiens_hsa043100.47865171
118T cell receptor signaling pathway_Homo sapiens_hsa046600.47834758
119NF-kappa B signaling pathway_Homo sapiens_hsa040640.47757242
120Dorso-ventral axis formation_Homo sapiens_hsa043200.47576430
121Cocaine addiction_Homo sapiens_hsa050300.47142792
122beta-Alanine metabolism_Homo sapiens_hsa004100.46535584
123Proteasome_Homo sapiens_hsa030500.46034763
124Phototransduction_Homo sapiens_hsa047440.44985131
125Carbon metabolism_Homo sapiens_hsa012000.44295293
126Type I diabetes mellitus_Homo sapiens_hsa049400.43952327
127Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.43385219
128RNA polymerase_Homo sapiens_hsa030200.43182124
129RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.43179769
130Vitamin B6 metabolism_Homo sapiens_hsa007500.42447182
131cGMP-PKG signaling pathway_Homo sapiens_hsa040220.41600739
132Arachidonic acid metabolism_Homo sapiens_hsa005900.41540986
133Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.40663025
134Dopaminergic synapse_Homo sapiens_hsa047280.40521489
135Oxytocin signaling pathway_Homo sapiens_hsa049210.40092697
136Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.39793833
137Biosynthesis of amino acids_Homo sapiens_hsa012300.39643989
138Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.38566381
139Carbohydrate digestion and absorption_Homo sapiens_hsa049730.38553463
140Linoleic acid metabolism_Homo sapiens_hsa005910.38277295
141Leishmaniasis_Homo sapiens_hsa051400.37565883
142MAPK signaling pathway_Homo sapiens_hsa040100.36990643
143Malaria_Homo sapiens_hsa051440.36790406
144Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.36622452
145Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.33846749
146Primary bile acid biosynthesis_Homo sapiens_hsa001200.33679194
147Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.33291838
148Steroid hormone biosynthesis_Homo sapiens_hsa001400.29710104
149Tryptophan metabolism_Homo sapiens_hsa003800.29648751
150alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.28886400
151Lysine degradation_Homo sapiens_hsa003100.28584535
152Chemical carcinogenesis_Homo sapiens_hsa052040.27631626
153Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.26866017
154Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.26665445
155Melanoma_Homo sapiens_hsa052180.23651456
156Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.22797072
157Arginine and proline metabolism_Homo sapiens_hsa003300.22678000
158Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.19639502
159Fat digestion and absorption_Homo sapiens_hsa049750.19142214

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