LRRD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1binding of sperm to zona pellucida (GO:0007339)9.70447938
2axonemal dynein complex assembly (GO:0070286)9.57407634
3epithelial cilium movement (GO:0003351)9.35468850
4motile cilium assembly (GO:0044458)8.78392658
5spermatid development (GO:0007286)8.54171810
6single fertilization (GO:0007338)8.23399737
7cilium movement (GO:0003341)7.93457800
8sperm capacitation (GO:0048240)7.56693103
9epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.55556306
10regulation of cilium movement (GO:0003352)7.09695462
11male meiosis (GO:0007140)6.89638306
12fertilization (GO:0009566)6.39838107
13piRNA metabolic process (GO:0034587)6.27928937
14synaptonemal complex organization (GO:0070193)6.26799494
15synaptonemal complex assembly (GO:0007130)6.09172548
16negative regulation of inclusion body assembly (GO:0090084)5.97460119
17microtubule depolymerization (GO:0007019)5.62140582
18spermatid nucleus differentiation (GO:0007289)5.61699149
19spermatogenesis (GO:0007283)5.56057862
20organic cation transport (GO:0015695)5.55701206
21male gamete generation (GO:0048232)5.53484267
22cell recognition (GO:0008037)5.51617544
23calcium ion-dependent exocytosis (GO:0017156)5.42490934
24behavioral response to nicotine (GO:0035095)5.34677808
25ventricular system development (GO:0021591)5.14450882
26gamete generation (GO:0007276)5.07975307
27cellular process involved in reproduction in multicellular organism (GO:0022412)4.95657588
28regulation of inclusion body assembly (GO:0090083)4.93617594
29microtubule severing (GO:0051013)4.84675984
30germ cell development (GO:0007281)4.61836847
31response to pheromone (GO:0019236)4.54551810
32chromosome organization involved in meiosis (GO:0070192)4.37737899
33DNA methylation involved in gamete generation (GO:0043046)4.21174950
34L-fucose catabolic process (GO:0042355)4.16757270
35fucose catabolic process (GO:0019317)4.16757270
36L-fucose metabolic process (GO:0042354)4.16757270
37regulation of microtubule-based movement (GO:0060632)4.03943005
38protein-cofactor linkage (GO:0018065)4.01453213
39multicellular organismal reproductive process (GO:0048609)3.97305829
40glycerol ether metabolic process (GO:0006662)3.94338175
41male meiosis I (GO:0007141)3.87723952
42seminiferous tubule development (GO:0072520)3.72995335
43meiotic nuclear division (GO:0007126)3.70719546
44monoubiquitinated protein deubiquitination (GO:0035520)3.68569034
45ether metabolic process (GO:0018904)3.66807653
46single strand break repair (GO:0000012)3.63763914
47lactate metabolic process (GO:0006089)3.61670241
48cellular ketone body metabolic process (GO:0046950)3.60582785
49platelet dense granule organization (GO:0060155)3.49726932
50alanine transport (GO:0032328)3.41767862
51chaperone-mediated protein complex assembly (GO:0051131)3.35620739
52protein localization to cilium (GO:0061512)3.34674739
53ketone body metabolic process (GO:1902224)3.30137231
54rRNA modification (GO:0000154)3.25977156
55microtubule polymerization or depolymerization (GO:0031109)3.24690128
56protein polyglutamylation (GO:0018095)3.24654139
57protein K11-linked deubiquitination (GO:0035871)3.22836954
58indole-containing compound catabolic process (GO:0042436)3.21823822
59indolalkylamine catabolic process (GO:0046218)3.21823822
60tryptophan catabolic process (GO:0006569)3.21823822
61multicellular organismal development (GO:0007275)3.21379196
62negative regulation of telomere maintenance (GO:0032205)3.19758541
63synapsis (GO:0007129)3.17748806
64centriole assembly (GO:0098534)3.17028285
65spinal cord motor neuron differentiation (GO:0021522)3.16528295
66nonmotile primary cilium assembly (GO:0035058)3.16387634
67detection of light stimulus involved in visual perception (GO:0050908)3.16352229
68detection of light stimulus involved in sensory perception (GO:0050962)3.16352229
69nephron epithelium morphogenesis (GO:0072088)3.14312774
70nephron tubule morphogenesis (GO:0072078)3.14312774
71somite development (GO:0061053)3.14150155
72alditol metabolic process (GO:0019400)3.11770570
73positive regulation of oligodendrocyte differentiation (GO:0048714)3.09987775
74genitalia morphogenesis (GO:0035112)3.09333140
75detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.06104428
76water-soluble vitamin biosynthetic process (GO:0042364)3.05398208
77gamma-aminobutyric acid transport (GO:0015812)2.99277709
78left/right pattern formation (GO:0060972)2.96148209
79kynurenine metabolic process (GO:0070189)2.95127940
80glycerol metabolic process (GO:0006071)2.95062523
81meiosis I (GO:0007127)2.94593203
82protein refolding (GO:0042026)2.94215533
83rRNA methylation (GO:0031167)2.93589272
84neuronal action potential (GO:0019228)2.92651345
85centriole replication (GO:0007099)2.89610513
86regulation of action potential (GO:0098900)2.89521450
87establishment of protein localization to mitochondrial membrane (GO:0090151)2.88842996
88cilium organization (GO:0044782)2.88527149
89regulation of hexokinase activity (GO:1903299)2.87980662
90regulation of glucokinase activity (GO:0033131)2.87980662
91mitochondrial respiratory chain complex I assembly (GO:0032981)2.87012642
92NADH dehydrogenase complex assembly (GO:0010257)2.87012642
93mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.87012642
94indolalkylamine metabolic process (GO:0006586)2.85766672
95photoreceptor cell maintenance (GO:0045494)2.85752298
96chromosome condensation (GO:0030261)2.84082766
97DNA deamination (GO:0045006)2.83232498
98protein complex biogenesis (GO:0070271)2.82788795
99cellular component assembly involved in morphogenesis (GO:0010927)2.82689083
100cilium assembly (GO:0042384)2.81690602
101preassembly of GPI anchor in ER membrane (GO:0016254)2.80585777
102microtubule-based movement (GO:0007018)2.80231734
103mannosylation (GO:0097502)2.77853150
104GTP biosynthetic process (GO:0006183)2.77577442
105sexual reproduction (GO:0019953)2.77121528
106intraciliary transport (GO:0042073)2.75715249
107positive regulation of fatty acid transport (GO:2000193)2.75627574
108proline transport (GO:0015824)2.74368319
109positive regulation of gastrulation (GO:2000543)2.71173495
110negative regulation of skeletal muscle tissue development (GO:0048642)2.70900283
111cell proliferation in forebrain (GO:0021846)2.70313361
112neuron fate determination (GO:0048664)2.67927532
113tryptophan metabolic process (GO:0006568)2.67738515
114behavioral response to ethanol (GO:0048149)2.66825140
115kidney morphogenesis (GO:0060993)2.65490276
116fucosylation (GO:0036065)2.65120734
117nucleoside diphosphate phosphorylation (GO:0006165)2.63685714
118polyol catabolic process (GO:0046174)2.63675157
119cilium morphogenesis (GO:0060271)2.63667623
120retinal cone cell development (GO:0046549)2.62848239
121mitochondrial respiratory chain complex assembly (GO:0033108)2.60696640
122regulation of mesoderm development (GO:2000380)2.60600694
123mitochondrial DNA replication (GO:0006264)2.60336329
124single-organism membrane fusion (GO:0044801)2.60047353
125calcium ion import (GO:0070509)2.60045657
126regulation of rhodopsin mediated signaling pathway (GO:0022400)2.59314914
127axoneme assembly (GO:0035082)2.58861286
128DNA packaging (GO:0006323)2.58564678
129neural tube formation (GO:0001841)2.57932903
130reciprocal meiotic recombination (GO:0007131)2.57818906
131reciprocal DNA recombination (GO:0035825)2.57818906
132membrane depolarization during action potential (GO:0086010)2.57403202
133positive regulation of defense response to virus by host (GO:0002230)2.57139111
134meiotic cell cycle (GO:0051321)2.54526459
135startle response (GO:0001964)2.53855778
136photoreceptor cell development (GO:0042461)2.51225263
137rhodopsin mediated signaling pathway (GO:0016056)2.49020502
138synaptic transmission, cholinergic (GO:0007271)2.47598840
139negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.46656055
140sulfation (GO:0051923)2.45581777
141respiratory chain complex IV assembly (GO:0008535)2.45522798
142hindbrain development (GO:0030902)2.45504861
143cysteine metabolic process (GO:0006534)2.43964681
144peptidyl-glutamic acid modification (GO:0018200)2.43835083
145cAMP catabolic process (GO:0006198)2.43649365
146limb bud formation (GO:0060174)2.42450425
147cell differentiation in spinal cord (GO:0021515)2.41846931
148peptidyl-threonine dephosphorylation (GO:0035970)2.40280660
149dopamine transport (GO:0015872)2.39829098
150glycolytic process (GO:0006096)2.39413263
151sequestering of actin monomers (GO:0042989)2.39229260
152DNA-dependent DNA replication (GO:0006261)2.38897230
153regulation of cytokine production involved in inflammatory response (GO:1900015)2.38721760
154UTP biosynthetic process (GO:0006228)2.36114962
155amino-acid betaine transport (GO:0015838)2.35407066
156carnitine transport (GO:0015879)2.35407066
157nucleus organization (GO:0006997)2.31393737
158regulation of spindle checkpoint (GO:0090231)2.29585287
159cell redox homeostasis (GO:0045454)2.29461878
160regulation of centriole replication (GO:0046599)2.23875994
161carnitine transmembrane transport (GO:1902603)2.20422300
162positive regulation of macrophage activation (GO:0043032)2.19439647
163fusion of sperm to egg plasma membrane (GO:0007342)15.9720538
164cell wall macromolecule metabolic process (GO:0044036)15.0602117
165cell wall macromolecule catabolic process (GO:0016998)15.0602117
166acrosome assembly (GO:0001675)13.2405099
167multicellular organism reproduction (GO:0032504)13.1643466
168plasma membrane fusion (GO:0045026)12.2196440
169sperm motility (GO:0030317)12.1970591
170sperm-egg recognition (GO:0035036)11.7810932
171cilium or flagellum-dependent cell motility (GO:0001539)11.5573202
172reproduction (GO:0000003)10.8547618
173cell-cell recognition (GO:0009988)10.8089498
174acrosome reaction (GO:0007340)10.3540748

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse7.50824819
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse5.47875689
3EZH2_22144423_ChIP-Seq_EOC_Human4.21177959
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.20735614
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.14459735
6GBX2_23144817_ChIP-Seq_PC3_Human2.71707224
7CBX2_27304074_Chip-Seq_ESCs_Mouse2.52390434
8FLI1_27457419_Chip-Seq_LIVER_Mouse2.47596353
9IGF1R_20145208_ChIP-Seq_DFB_Human2.42647224
10ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.41373787
11CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.33407324
12ZNF274_21170338_ChIP-Seq_K562_Hela2.27975125
13PCGF2_27294783_Chip-Seq_ESCs_Mouse2.23949960
14GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.21082412
15PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.07023084
16ZFP57_27257070_Chip-Seq_ESCs_Mouse2.06909835
17VDR_22108803_ChIP-Seq_LS180_Human2.02724602
18FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.01746502
19KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse2.01386150
20EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.99227571
21P300_19829295_ChIP-Seq_ESCs_Human1.96409131
22TAF15_26573619_Chip-Seq_HEK293_Human1.91122013
23RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.88964602
24EWS_26573619_Chip-Seq_HEK293_Human1.84882047
25CTBP2_25329375_ChIP-Seq_LNCAP_Human1.82764940
26HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.80644970
27TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.77613272
28KDM2B_26808549_Chip-Seq_REH_Human1.77232023
29SALL1_21062744_ChIP-ChIP_HESCs_Human1.75512044
30E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.69399056
31TAL1_26923725_Chip-Seq_HPCs_Mouse1.68216729
32TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.66311104
33AR_21572438_ChIP-Seq_LNCaP_Human1.63371924
34STAT6_21828071_ChIP-Seq_BEAS2B_Human1.62573771
35KAP1_22055183_ChIP-Seq_ESCs_Mouse1.62509018
36NANOG_18555785_Chip-Seq_ESCs_Mouse1.61947050
37MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.61341024
38PCGF2_27294783_Chip-Seq_NPCs_Mouse1.59399687
39BMI1_23680149_ChIP-Seq_NPCS_Mouse1.57944937
40GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.55746102
41RNF2_27304074_Chip-Seq_NSC_Mouse1.55294383
42STAT1_17558387_ChIP-Seq_HELA_Human1.52302883
43EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.52195219
44AR_25329375_ChIP-Seq_VCAP_Human1.50568486
45SUZ12_27294783_Chip-Seq_NPCs_Mouse1.50064026
46NFE2_27457419_Chip-Seq_LIVER_Mouse1.49470858
47MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.47687782
48REST_21632747_ChIP-Seq_MESCs_Mouse1.45941461
49ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.45667013
50CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.44583396
51CMYC_18555785_Chip-Seq_ESCs_Mouse1.43820243
52PIAS1_25552417_ChIP-Seq_VCAP_Human1.43564626
53TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43132560
54BCAT_22108803_ChIP-Seq_LS180_Human1.43119628
55ELK4_26923725_Chip-Seq_MESODERM_Mouse1.41973893
56P53_22387025_ChIP-Seq_ESCs_Mouse1.41162690
57TOP2B_26459242_ChIP-Seq_MCF-7_Human1.39900387
58NANOG_19829295_ChIP-Seq_ESCs_Human1.39758742
59SOX2_19829295_ChIP-Seq_ESCs_Human1.39758742
60AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.38848477
61OCT4_18555785_Chip-Seq_ESCs_Mouse1.38315130
62STAT3_23295773_ChIP-Seq_U87_Human1.37011465
63ETV2_25802403_ChIP-Seq_MESCs_Mouse1.36854233
64SMAD3_21741376_ChIP-Seq_EPCs_Human1.35928569
65FLI1_21867929_ChIP-Seq_TH2_Mouse1.35588922
66EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.35567233
67WDR5_24793694_ChIP-Seq_LNCAP_Human1.34701826
68GATA3_21878914_ChIP-Seq_MCF-7_Human1.34568680
69SUZ12_18555785_Chip-Seq_ESCs_Mouse1.34179961
70P300_18555785_Chip-Seq_ESCs_Mouse1.34067518
71TP53_22573176_ChIP-Seq_HFKS_Human1.33253831
72HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.32475850
73IRF1_19129219_ChIP-ChIP_H3396_Human1.32293570
74FOXA1_27270436_Chip-Seq_PROSTATE_Human1.31699926
75FOXA1_25329375_ChIP-Seq_VCAP_Human1.31699926
76MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.30395586
77NR3C1_21868756_ChIP-Seq_MCF10A_Human1.29810225
78GATA3_21867929_ChIP-Seq_TH1_Mouse1.29716657
79CRX_20693478_ChIP-Seq_RETINA_Mouse1.29499024
80CBP_20019798_ChIP-Seq_JUKART_Human1.28724786
81IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.28724786
82ER_23166858_ChIP-Seq_MCF-7_Human1.27512521
83TCF4_22108803_ChIP-Seq_LS180_Human1.26338567
84KLF4_18555785_Chip-Seq_ESCs_Mouse1.25967537
85PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.24974793
86MYC_18940864_ChIP-ChIP_HL60_Human1.24528491
87SOX2_18555785_Chip-Seq_ESCs_Mouse1.21896092
88EZH2_27294783_Chip-Seq_NPCs_Mouse1.21365841
89RUNX2_22187159_ChIP-Seq_PCA_Human1.21029356
90KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.20476569
91NCOR_22424771_ChIP-Seq_293T_Human1.20225296
92GF1_26923725_Chip-Seq_HPCs_Mouse1.19171723
93FOXA1_21572438_ChIP-Seq_LNCaP_Human1.19105195
94FUS_26573619_Chip-Seq_HEK293_Human1.18808917
95SMAD4_21741376_ChIP-Seq_EPCs_Human1.18178672
96STAT3_18555785_Chip-Seq_ESCs_Mouse1.18168705
97SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.18110327
98GATA1_26923725_Chip-Seq_HPCs_Mouse1.17432874
99CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.17097117
100ESRRB_18555785_Chip-Seq_ESCs_Mouse1.16481387
101E2F1_18555785_Chip-Seq_ESCs_Mouse1.16124594
102GATA3_21867929_ChIP-Seq_CD8_Mouse1.16120669
103LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.15773897
104KLF5_20875108_ChIP-Seq_MESCs_Mouse1.15532018
105RUNX1_27457419_Chip-Seq_LIVER_Mouse1.15080084
106AUTS2_25519132_ChIP-Seq_293T-REX_Human1.14447115
107GABP_17652178_ChIP-ChIP_JURKAT_Human1.14429804
108GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.13963128
109EZH2_27304074_Chip-Seq_ESCs_Mouse1.13954017
110CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.13102303
111AR_20517297_ChIP-Seq_VCAP_Human1.12908013
112EED_16625203_ChIP-ChIP_MESCs_Mouse1.12583625
113FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12380344
114ERA_21632823_ChIP-Seq_H3396_Human1.11314471
115NOTCH1_21737748_ChIP-Seq_TLL_Human1.11067363
116CTCF_18555785_Chip-Seq_ESCs_Mouse1.10895159
117TAF2_19829295_ChIP-Seq_ESCs_Human1.10809956
118MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.09779556
119PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.09525448
120OCT4_21477851_ChIP-Seq_ESCs_Mouse1.07873349
121PU1_27457419_Chip-Seq_LIVER_Mouse1.07524858
122CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.06293162
123JARID2_20064375_ChIP-Seq_MESCs_Mouse1.06186766
124CTBP1_25329375_ChIP-Seq_LNCAP_Human1.05895915
125SOX9_26525672_Chip-Seq_HEART_Mouse1.05669636
126PRDM14_20953172_ChIP-Seq_ESCs_Human1.05442965
127NMYC_18555785_Chip-Seq_ESCs_Mouse1.05411929
128EZH2_27294783_Chip-Seq_ESCs_Mouse1.05367941
129SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.05251572
130REST_18959480_ChIP-ChIP_MESCs_Mouse1.04539343
131NANOG_20526341_ChIP-Seq_ESCs_Human1.04088011
132SMAD1_18555785_Chip-Seq_ESCs_Mouse1.03290001
133KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.03198925
134P53_21459846_ChIP-Seq_SAOS-2_Human1.03094700
135MYC_19829295_ChIP-Seq_ESCs_Human1.02683627
136EST1_17652178_ChIP-ChIP_JURKAT_Human1.02472308
137RBPJ_22232070_ChIP-Seq_NCS_Mouse1.01530288
138SOX2_22085726_ChIP-Seq_NPCs_Mouse1.00937350
139CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.00707593
140GF1B_26923725_Chip-Seq_HPCs_Mouse1.00067138
141DROSHA_22980978_ChIP-Seq_HELA_Human0.99404964
142HOXB7_26014856_ChIP-Seq_BT474_Human0.98854129
143SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.98748600
144SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.97211078
145SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.96458217
146RUNX1_26923725_Chip-Seq_HPCs_Mouse0.96350831
147ZFX_18555785_Chip-Seq_ESCs_Mouse0.96275185
148OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.95468934
149PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.95158887
150TCF4_23295773_ChIP-Seq_U87_Human0.94290965
151CDX2_19796622_ChIP-Seq_MESCs_Mouse0.93822466
152EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.93720034
153POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.93179750
154TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93179750
155SMAD4_21799915_ChIP-Seq_A2780_Human0.92938665
156POU3F2_20337985_ChIP-ChIP_501MEL_Human0.92713019
157STAT3_18555785_ChIP-Seq_MESCs_Mouse0.90552065
158UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.90317616
159CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.89857074
160NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.89577665
161SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.89056494
162EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.86429871

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.59408897
2MP0001929_abnormal_gametogenesis4.89160635
3MP0008877_abnormal_DNA_methylation4.34511007
4MP0003136_yellow_coat_color3.72267934
5MP0002210_abnormal_sex_determination2.96708888
6MP0002161_abnormal_fertility/fecundity2.93719098
7MP0002653_abnormal_ependyma_morphology2.65633220
8MP0009046_muscle_twitch2.55932684
9MP0001145_abnormal_male_reproductive2.55394204
10MP0000569_abnormal_digit_pigmentation2.41011761
11MP0002638_abnormal_pupillary_reflex2.39282296
12MP0000653_abnormal_sex_gland2.20781364
13MP0003880_abnormal_central_pattern2.18264465
14MP0005623_abnormal_meninges_morphology2.13767835
15MP0003195_calcinosis2.11059917
16MP0001986_abnormal_taste_sensitivity2.04585523
17MP0002837_dystrophic_cardiac_calcinosis2.04287442
18MP0005410_abnormal_fertilization15.1120654
19MP0005670_abnormal_white_adipose1.96403145
20MP0002938_white_spotting1.94366246
21MP0006072_abnormal_retinal_apoptosis1.90213572
22MP0001485_abnormal_pinna_reflex1.84276007
23MP0005253_abnormal_eye_physiology1.79501431
24MP0002234_abnormal_pharynx_morphology1.76959250
25MP0008875_abnormal_xenobiotic_pharmacok1.75498983
26MP0003787_abnormal_imprinting1.72545562
27MP0003283_abnormal_digestive_organ1.71333230
28MP0006292_abnormal_olfactory_placode1.70725128
29MP0000372_irregular_coat_pigmentation1.69834837
30MP0005084_abnormal_gallbladder_morpholo1.65266018
31MP0005647_abnormal_sex_gland1.58114687
32MP0005646_abnormal_pituitary_gland1.56569836
33MP0004133_heterotaxia1.53781438
34MP0003011_delayed_dark_adaptation1.52778021
35MP0001486_abnormal_startle_reflex1.52075917
36MP0005645_abnormal_hypothalamus_physiol1.48906121
37MP0002160_abnormal_reproductive_system1.48320014
38MP0005174_abnormal_tail_pigmentation1.46297170
39MP0004742_abnormal_vestibular_system1.44091110
40MP0002139_abnormal_hepatobiliary_system1.43005638
41MP0002282_abnormal_trachea_morphology1.40366021
42MP0000631_abnormal_neuroendocrine_gland1.38207592
43MP0001968_abnormal_touch/_nociception1.32947782
44MP0004043_abnormal_pH_regulation1.31795787
45MP0004859_abnormal_synaptic_plasticity1.29056813
46MP0001501_abnormal_sleep_pattern1.23964437
47MP0001765_abnormal_ion_homeostasis1.22360444
48MP0003635_abnormal_synaptic_transmissio1.18052217
49MP0005379_endocrine/exocrine_gland_phen1.16995388
50MP0000026_abnormal_inner_ear1.16334199
51MP0004233_abnormal_muscle_weight1.10147820
52MP0005195_abnormal_posterior_eye1.08124634
53MP0002876_abnormal_thyroid_physiology1.07595096
54MP0001984_abnormal_olfaction1.06213579
55MP0000920_abnormal_myelination1.05427336
56MP0004147_increased_porphyrin_level1.05109394
57MP0002736_abnormal_nociception_after1.04398243
58MP0003718_maternal_effect1.04380543
59MP0003122_maternal_imprinting0.99926324
60MP0009745_abnormal_behavioral_response0.99778947
61MP0002095_abnormal_skin_pigmentation0.99593111
62MP0010386_abnormal_urinary_bladder0.99002061
63MP0002735_abnormal_chemical_nociception0.97523054
64MP0000427_abnormal_hair_cycle0.97463154
65MP0001963_abnormal_hearing_physiology0.96596983
66MP0005332_abnormal_amino_acid0.96583723
67MP0002063_abnormal_learning/memory/cond0.96023619
68MP0001905_abnormal_dopamine_level0.94871371
69MP0002752_abnormal_somatic_nervous0.93658227
70MP0002277_abnormal_respiratory_mucosa0.93481192
71MP0002064_seizures0.93076306
72MP0004924_abnormal_behavior0.92640436
73MP0005386_behavior/neurological_phenoty0.92640436
74MP0001293_anophthalmia0.91265452
75MP0002751_abnormal_autonomic_nervous0.90099963
76MP0001324_abnormal_eye_pigmentation0.89603740
77MP0001502_abnormal_circadian_rhythm0.89361645
78MP0003183_abnormal_peptide_metabolism0.89045532
79MP0000049_abnormal_middle_ear0.88639209
80MP0003121_genomic_imprinting0.87803665
81MP0000230_abnormal_systemic_arterial0.86384440
82MP0004270_analgesia0.85331565
83MP0005423_abnormal_somatic_nervous0.84874118
84MP0005075_abnormal_melanosome_morpholog0.84681180
85MP0003119_abnormal_digestive_system0.84604226
86MP0006035_abnormal_mitochondrial_morpho0.83813374
87MP0002572_abnormal_emotion/affect_behav0.83685996
88MP0002272_abnormal_nervous_system0.83115880
89MP0001919_abnormal_reproductive_system0.82820911
90MP0004215_abnormal_myocardial_fiber0.82581343
91MP0000685_abnormal_immune_system0.78539786
92MP0002102_abnormal_ear_morphology0.76604129
93MP0008995_early_reproductive_senescence0.76529998
94MP0002796_impaired_skin_barrier0.75866489
95MP0002928_abnormal_bile_duct0.75517638
96MP0008569_lethality_at_weaning0.75135547
97MP0005171_absent_coat_pigmentation0.74396400
98MP0008057_abnormal_DNA_replication0.71536650
99MP0003633_abnormal_nervous_system0.69951131
100MP0004142_abnormal_muscle_tone0.64668889
101MP0001529_abnormal_vocalization0.58070022
102MP0005636_abnormal_mineral_homeostasis0.57621377
103MP0005389_reproductive_system_phenotype0.57378899
104MP0002067_abnormal_sensory_capabilities0.55578966
105MP0003631_nervous_system_phenotype0.54937374
106MP0002557_abnormal_social/conspecific_i0.52340348
107MP0005551_abnormal_eye_electrophysiolog0.51509401
108MP0002734_abnormal_mechanical_nocicepti0.51276024
109MP0002822_catalepsy0.50680729
110MP0003329_amyloid_beta_deposits0.48438363
111MP0006276_abnormal_autonomic_nervous0.48383462
112MP0001440_abnormal_grooming_behavior0.46132002
113MP0008058_abnormal_DNA_repair0.45910638
114MP0002163_abnormal_gland_morphology0.45682522
115MP0005451_abnormal_body_composition0.45515077
116MP0002133_abnormal_respiratory_system0.44366704
117MP0005388_respiratory_system_phenotype0.44366704
118MP0002066_abnormal_motor_capabilities/c0.42694382
119MP0003879_abnormal_hair_cell0.42550601
120MP0006082_CNS_inflammation0.41412060
121MP0000778_abnormal_nervous_system0.41374092
122MP0001873_stomach_inflammation0.41239188
123MP0010234_abnormal_vibrissa_follicle0.40657438
124MP0004811_abnormal_neuron_physiology0.40532362
125MP0002138_abnormal_hepatobiliary_system0.40233831
126MP0001177_atelectasis0.39436279
127MP0002152_abnormal_brain_morphology0.38838060
128MP0004885_abnormal_endolymph0.38346287
129MP0002108_abnormal_muscle_morphology0.36913841
130MP0008872_abnormal_physiological_respon0.36645334
131MP0005377_hearing/vestibular/ear_phenot0.36297669
132MP0003878_abnormal_ear_physiology0.36297669
133MP0002971_abnormal_brown_adipose0.36037275
134MP0005666_abnormal_adipose_tissue0.35701299
135MP0001664_abnormal_digestion0.35354146
136MP0001970_abnormal_pain_threshold0.35052319
137MP0000955_abnormal_spinal_cord0.34639117
138MP0002733_abnormal_thermal_nociception0.34517436
139MP0002229_neurodegeneration0.33768402
140MP0005310_abnormal_salivary_gland0.33740785
141MP0002882_abnormal_neuron_morphology0.33160516
142MP0000462_abnormal_digestive_system0.30753669
143MP0000604_amyloidosis0.30478523
144MP0003950_abnormal_plasma_membrane0.30473392
145MP0003634_abnormal_glial_cell0.30329019
146MP0005397_hematopoietic_system_phenotyp0.30051957
147MP0001545_abnormal_hematopoietic_system0.30051957
148MP0005535_abnormal_body_temperature0.29912154
149MP0003646_muscle_fatigue0.29022761
150MP0003699_abnormal_female_reproductive0.28988986
151MP0004510_myositis0.28002736
152MP0010678_abnormal_skin_adnexa0.26642391
153MP0002269_muscular_atrophy0.26281292
154MP0003861_abnormal_nervous_system0.25693930

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.23867337
2Abnormal respiratory motile cilium morphology (HP:0005938)8.76967259
3Abnormal respiratory epithelium morphology (HP:0012253)8.76967259
4Abnormal ciliary motility (HP:0012262)7.72942499
5Rhinitis (HP:0012384)7.38874373
6Chronic bronchitis (HP:0004469)7.28609299
7Nasal polyposis (HP:0100582)6.11297416
8Infertility (HP:0000789)5.67868216
9Abnormality of the nasal mucosa (HP:0000433)4.88725217
10Congenital stationary night blindness (HP:0007642)4.46784989
11Bronchitis (HP:0012387)4.41220895
12Pancreatic cysts (HP:0001737)4.38833388
13True hermaphroditism (HP:0010459)4.32276049
14Bronchiectasis (HP:0002110)4.22012202
15Nephronophthisis (HP:0000090)3.81065097
16Recurrent sinusitis (HP:0011108)3.74224422
17Medial flaring of the eyebrow (HP:0010747)3.49719725
18Male infertility (HP:0003251)3.47380618
19Chronic hepatic failure (HP:0100626)3.43332099
20Abnormal spermatogenesis (HP:0008669)3.24139153
21Attenuation of retinal blood vessels (HP:0007843)3.16411303
22Recurrent otitis media (HP:0000403)3.02811992
23Abnormality of the renal medulla (HP:0100957)3.02366397
24Abolished electroretinogram (ERG) (HP:0000550)3.01617023
25Abnormal rod and cone electroretinograms (HP:0008323)2.74605378
26Cystic liver disease (HP:0006706)2.65231590
27Increased corneal curvature (HP:0100692)2.63669997
28Keratoconus (HP:0000563)2.63669997
29Gait imbalance (HP:0002141)2.61397399
30Sclerocornea (HP:0000647)2.61029531
31Congenital primary aphakia (HP:0007707)2.58423912
32Chorioretinal atrophy (HP:0000533)2.53292665
33Azoospermia (HP:0000027)2.51263368
34Recurrent bronchitis (HP:0002837)2.49628626
35Pendular nystagmus (HP:0012043)2.48527565
36Anencephaly (HP:0002323)2.47118772
37Furrowed tongue (HP:0000221)2.46897003
38Congenital, generalized hypertrichosis (HP:0004540)2.45866843
39Tubulointerstitial fibrosis (HP:0005576)2.43663817
40Tubular atrophy (HP:0000092)2.40416706
41Large for gestational age (HP:0001520)2.36903062
42Bony spicule pigmentary retinopathy (HP:0007737)2.35386309
43Abnormality of saccadic eye movements (HP:0000570)2.34984857
44Occipital encephalocele (HP:0002085)2.31500257
45Tubulointerstitial abnormality (HP:0001969)2.30267059
46Hyperventilation (HP:0002883)2.30163902
47Inability to walk (HP:0002540)2.26474331
48Tongue fasciculations (HP:0001308)2.25190860
49Acute necrotizing encephalopathy (HP:0006965)2.24180815
50Polyuria (HP:0000103)2.23689752
51Abnormality of alanine metabolism (HP:0010916)2.23563496
52Hyperalaninemia (HP:0003348)2.23563496
53Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.23563496
54Concave nail (HP:0001598)2.22524639
55Nephrogenic diabetes insipidus (HP:0009806)2.20897501
56Male pseudohermaphroditism (HP:0000037)2.20558145
57Abnormality of midbrain morphology (HP:0002418)2.19976335
58Molar tooth sign on MRI (HP:0002419)2.19976335
59Lissencephaly (HP:0001339)2.19517007
60Sensory axonal neuropathy (HP:0003390)2.15463464
61Congenital sensorineural hearing impairment (HP:0008527)2.15286433
62Mitochondrial inheritance (HP:0001427)2.12482235
63Vaginal atresia (HP:0000148)2.05586311
64Genital tract atresia (HP:0001827)2.05163486
65Acute encephalopathy (HP:0006846)2.04850087
66Chronic sinusitis (HP:0011109)2.03349827
67Constricted visual fields (HP:0001133)2.03197588
68Absent rod-and cone-mediated responses on ERG (HP:0007688)2.01699817
69Renal cortical cysts (HP:0000803)2.01686846
70Muscle fibrillation (HP:0010546)2.00181361
71Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.4755020
72Dynein arm defect of respiratory motile cilia (HP:0012255)12.7342662
73Absent/shortened dynein arms (HP:0200106)12.7342662
74Decreased circulating renin level (HP:0003351)1.98638700
75Bell-shaped thorax (HP:0001591)1.98569197
76Increased CSF lactate (HP:0002490)1.98402210
77Bilateral microphthalmos (HP:0007633)1.98244096
78Optic disc pallor (HP:0000543)1.97372034
79Progressive macrocephaly (HP:0004481)1.95531948
80Neuroendocrine neoplasm (HP:0100634)1.95120344
81Aplasia/hypoplasia of the uterus (HP:0008684)1.94637134
82Tubulointerstitial nephritis (HP:0001970)1.93435363
83Anophthalmia (HP:0000528)1.92747431
84Poor coordination (HP:0002370)1.88195084
85Abnormal mitochondria in muscle tissue (HP:0008316)1.88150036
86Abnormal urine output (HP:0012590)1.88027285
87Anterior segment dysgenesis (HP:0007700)1.86784798
88Abnormality of the renal cortex (HP:0011035)1.85602621
89Abnormality of ocular smooth pursuit (HP:0000617)1.85478162
90Aplasia/Hypoplasia of the lens (HP:0008063)1.83941680
91Hyperglycinuria (HP:0003108)1.83914590
92Lipid accumulation in hepatocytes (HP:0006561)1.83020166
93Slow saccadic eye movements (HP:0000514)1.82893787
94Aplasia/Hypoplasia of the tibia (HP:0005772)1.82445663
95Abnormality of macular pigmentation (HP:0008002)1.82349963
96Optic nerve hypoplasia (HP:0000609)1.82291881
97Hepatocellular necrosis (HP:0001404)1.82063252
98Amelogenesis imperfecta (HP:0000705)1.81920668
99Focal motor seizures (HP:0011153)1.78999501
100Pheochromocytoma (HP:0002666)1.78747654
101Abnormal gallbladder physiology (HP:0012438)1.78251401
102Cholecystitis (HP:0001082)1.78251401
103Abnormality of the dental root (HP:0006486)1.76464663
104Taurodontia (HP:0000679)1.76464663
105Abnormality of permanent molar morphology (HP:0011071)1.76464663
106Progressive inability to walk (HP:0002505)1.75728565
107Impaired smooth pursuit (HP:0007772)1.75119684
108Oligodactyly (hands) (HP:0001180)1.74442864
109Decreased central vision (HP:0007663)1.74250172
110Tachypnea (HP:0002789)1.73972863
111Hemiparesis (HP:0001269)1.73770940
112Patellar aplasia (HP:0006443)1.72932772
113Hepatic necrosis (HP:0002605)1.72068670
114Methylmalonic acidemia (HP:0002912)1.71746008
115Severe visual impairment (HP:0001141)1.71413436
116Polyphagia (HP:0002591)1.71317578
117Polydipsia (HP:0001959)1.70438206
118Abnormal drinking behavior (HP:0030082)1.70438206
119Impulsivity (HP:0100710)1.65507191
120Abnormality of molar (HP:0011077)1.64142451
121Abnormality of molar morphology (HP:0011070)1.64142451
122Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.62424097
123Stage 5 chronic kidney disease (HP:0003774)1.61222947
124Delayed gross motor development (HP:0002194)1.60214366
125Abnormality of renal excretion (HP:0011036)1.57547946
126Postaxial foot polydactyly (HP:0001830)1.56986238
127Postaxial hand polydactyly (HP:0001162)1.56657438
128Retinal dysplasia (HP:0007973)1.56453178
129Gaze-evoked nystagmus (HP:0000640)1.56449095
130Spastic tetraparesis (HP:0001285)1.55936728
131Type II lissencephaly (HP:0007260)1.55341158
132Abnormality of the dental pulp (HP:0006479)1.54912969
133Hypoplasia of the capital femoral epiphysis (HP:0003090)1.53123326
134J-shaped sella turcica (HP:0002680)1.51556263
135Limb ataxia (HP:0002070)1.50237926
136Microglossia (HP:0000171)1.50051130
137Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.47181848
138Progressive cerebellar ataxia (HP:0002073)1.45867041
139Neurofibrillary tangles (HP:0002185)1.45394357
140Gonadotropin excess (HP:0000837)1.44729558
141Pancreatic fibrosis (HP:0100732)1.42520885
142Congenital hepatic fibrosis (HP:0002612)1.42019140
143Cerebellar dysplasia (HP:0007033)1.38118396
144Vascular calcification (HP:0004934)1.36051054
145Bile duct proliferation (HP:0001408)1.34879467
146Abnormal biliary tract physiology (HP:0012439)1.34879467
147Chronic otitis media (HP:0000389)1.34616212
148Dyschromatopsia (HP:0007641)1.33747040
149Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.33164190
150Absent frontal sinuses (HP:0002688)1.31745289
151Short ribs (HP:0000773)1.30975148
152Oculomotor apraxia (HP:0000657)1.30955098
153Choroideremia (HP:0001139)1.29360023
154Cerebral inclusion bodies (HP:0100314)1.23990725
155Decreased electroretinogram (ERG) amplitude (HP:0000654)1.22993973
156Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.22751174
157Deformed sella turcica (HP:0002681)1.22387843
158Cardiovascular calcification (HP:0011915)1.21641794
159Aplasia/Hypoplasia of the tongue (HP:0010295)1.20112331
160Abnormality of the neuromuscular junction (HP:0003398)1.20107072
161Fatigable weakness (HP:0003473)1.20107072
162Type 2 muscle fiber atrophy (HP:0003554)1.19422397
163Broad foot (HP:0001769)1.18041687

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK48.50942075
2PDK38.50942075
3PDK25.50623755
4TESK14.17685156
5FRK4.14857232
6STK393.35913986
7BMPR1B3.27911282
8ICK3.23973324
9PRKD33.06294067
10WNK42.84090680
11WNK32.83044066
12TAOK32.41644041
13TLK12.37386646
14ZAK2.33589207
15MAP4K22.23581728
16GRK12.23450883
17INSRR2.20640446
18PTK2B2.10833557
19NUAK12.04697689
20MAP3K91.79547912
21WEE11.59533194
22VRK21.58025439
23MAPK131.54126332
24VRK11.49928550
25ACVR1B1.47452763
26DAPK21.47333279
27STK381.46864240
28DYRK21.41508828
29PNCK1.36204734
30DYRK1B1.35722459
31PDK11.29050379
32TGFBR11.26625087
33RIPK41.25827414
34MST1R1.25517067
35MAP2K71.16190280
36LMTK21.12740700
37ADRBK21.09567416
38ARAF1.08796280
39WNK11.08475663
40MKNK21.06521097
41MARK21.03550876
42ADRBK10.99715079
43MARK10.98578139
44DYRK30.93549288
45TIE10.90247043
46TNIK0.88591472
47MUSK0.88176133
48PRKCE0.85233005
49PHKG20.79929377
50PHKG10.79929377
51PDPK10.79831663
52TYRO30.78133440
53PKN10.76169877
54NEK20.74363206
55CSNK1G10.72641591
56LIMK10.71367290
57MAPKAPK50.71001717
58CSNK1G30.69983535
59NTRK30.67979143
60EPHA40.67883647
61STK30.67152030
62PLK20.65662345
63IRAK10.65651430
64PAK30.64994778
65TSSK60.64246514
66CCNB10.63993583
67MAP3K130.63985340
68MAP2K20.62723394
69CDK80.59939618
70YES10.58585371
71TRIM280.58245420
72PIK3CA0.57198272
73BCKDK0.57090854
74GRK70.56794207
75RPS6KA50.56212112
76CASK0.55773327
77OXSR10.55665297
78TAF10.54866058
79CSNK1A1L0.54707955
80PRKCQ0.53059087
81TEC0.52896420
82PRKCG0.52429013
83CDK30.49049957
84IKBKB0.48801658
85CSNK1G20.46612763
86MKNK10.46612272
87BRAF0.46597202
88EPHA30.46460550
89PLK30.46453855
90CAMKK20.44124389
91MAP2K60.44120817
92SIK20.43736132
93PRKACA0.42459828
94SCYL20.42306608
95CAMK2A0.42219485
96CSNK1A10.41708692
97MAP3K40.41184880
98MARK30.40650048
99IRAK20.39876533
100BMX0.37524402
101ITK0.36870607
102OBSCN0.35580960
103MAPK150.34934506
104PLK40.34856812
105CAMK10.34546317
106BRSK20.34230030
107SYK0.34052979
108CAMK2B0.32450808
109MAPKAPK30.31553362
110CHEK20.30940044
111KIT0.30334299
112PRKCI0.29599366
113CAMK1G0.29014466
114CHUK0.28574395
115PAK10.27623495
116TTK0.27001741
117STK38L0.26731901
118ERBB40.26412695
119TXK0.26021133
120GRK60.24786168
121PRKACB0.24757075
122PRKG10.24715017
123NTRK20.23573253
124GRK50.22153058
125CHEK10.22092169
126CSNK1D0.21676101
127STK100.20905029
128MST40.20525904
129CDK150.20447636
130LATS10.19746626
131FGFR20.19298065
132MINK10.19136760
133CDK180.19094918
134BCR0.18078611
135ZAP700.17918180
136EGFR0.17780426
137STK110.17564858
138EPHB10.16848234
139DYRK1A0.16817152
140CDK140.16056416
141MAP3K140.15894947
142ATM0.15556129
143PRKCZ0.14982585
144CSNK2A20.12485136
145CDK50.11925216
146MET0.11915066
147CDK11A0.11375685
148CSF1R0.10866671
149PRKCB0.09537122
150MAP4K10.08804850
151PASK0.08728065
152PINK10.08053616
153PRKCA0.07925508
154EIF2AK30.07681577
155RPS6KB10.07095342
156PRKCD0.06861718
157CAMK2G0.06858963
158FGR0.05478709
159SGK2230.05259933
160SGK4940.05259933
161BRSK10.05163763

Predicted pathways (KEGG)

RankGene SetZ-score
1Pyruvate metabolism_Homo sapiens_hsa006203.67725938
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.33211337
3Vitamin B6 metabolism_Homo sapiens_hsa007503.17941860
4Phototransduction_Homo sapiens_hsa047443.00989178
5Linoleic acid metabolism_Homo sapiens_hsa005912.97939776
6Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.91447662
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.90630612
8Maturity onset diabetes of the young_Homo sapiens_hsa049502.74790609
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.71558693
10Propanoate metabolism_Homo sapiens_hsa006402.70197745
11Fatty acid biosynthesis_Homo sapiens_hsa000612.67669057
12Nitrogen metabolism_Homo sapiens_hsa009102.62263048
13Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.56871633
14Amphetamine addiction_Homo sapiens_hsa050312.39206572
15Collecting duct acid secretion_Homo sapiens_hsa049662.31312226
16Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.22711102
17Glycosaminoglycan degradation_Homo sapiens_hsa005312.20357185
18Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.19596351
19Butanoate metabolism_Homo sapiens_hsa006502.16145301
20Synaptic vesicle cycle_Homo sapiens_hsa047212.12347891
21Glucagon signaling pathway_Homo sapiens_hsa049222.05562734
22Parkinsons disease_Homo sapiens_hsa050122.04044231
23Glycerolipid metabolism_Homo sapiens_hsa005611.92690884
24Ether lipid metabolism_Homo sapiens_hsa005651.89650228
25Basal transcription factors_Homo sapiens_hsa030221.87076755
26Protein export_Homo sapiens_hsa030601.85519616
27Pentose phosphate pathway_Homo sapiens_hsa000301.76114700
28Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.69374094
29Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.66256278
30RNA polymerase_Homo sapiens_hsa030201.66156183
31Nicotine addiction_Homo sapiens_hsa050331.59176313
32Glycerophospholipid metabolism_Homo sapiens_hsa005641.56761804
33Homologous recombination_Homo sapiens_hsa034401.55108722
34Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.49365772
35One carbon pool by folate_Homo sapiens_hsa006701.49132603
36Sulfur relay system_Homo sapiens_hsa041221.48200773
37Ribosome_Homo sapiens_hsa030101.46721287
38Huntingtons disease_Homo sapiens_hsa050161.45095164
39Tryptophan metabolism_Homo sapiens_hsa003801.44941935
40Selenocompound metabolism_Homo sapiens_hsa004501.40726485
41Primary bile acid biosynthesis_Homo sapiens_hsa001201.38119756
42Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.35993909
43Long-term potentiation_Homo sapiens_hsa047201.34967811
44Caffeine metabolism_Homo sapiens_hsa002321.32196835
45Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.32096882
46Cocaine addiction_Homo sapiens_hsa050301.27600590
47Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.25726332
48Antigen processing and presentation_Homo sapiens_hsa046121.25323349
49Dorso-ventral axis formation_Homo sapiens_hsa043201.23456934
50Circadian entrainment_Homo sapiens_hsa047131.23070976
51Alzheimers disease_Homo sapiens_hsa050101.20285801
52Oocyte meiosis_Homo sapiens_hsa041141.19999468
53PPAR signaling pathway_Homo sapiens_hsa033201.19647815
54Renin-angiotensin system_Homo sapiens_hsa046141.18413237
55Renin secretion_Homo sapiens_hsa049241.16940842
56Cardiac muscle contraction_Homo sapiens_hsa042601.15700740
57Cysteine and methionine metabolism_Homo sapiens_hsa002701.13366002
58Vibrio cholerae infection_Homo sapiens_hsa051101.13120388
59RNA degradation_Homo sapiens_hsa030181.12201082
60Mineral absorption_Homo sapiens_hsa049781.10158049
61Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.05644116
62Peroxisome_Homo sapiens_hsa041461.04901444
63Carbon metabolism_Homo sapiens_hsa012001.01905781
64Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.01093169
65Carbohydrate digestion and absorption_Homo sapiens_hsa049731.00312224
66Histidine metabolism_Homo sapiens_hsa003400.99265081
67Calcium signaling pathway_Homo sapiens_hsa040200.98798429
68Cyanoamino acid metabolism_Homo sapiens_hsa004600.93097176
69Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.93031672
70Glutamatergic synapse_Homo sapiens_hsa047240.92955313
71Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.92732370
72Gastric acid secretion_Homo sapiens_hsa049710.88692096
73Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.87856567
74Serotonergic synapse_Homo sapiens_hsa047260.87286961
75Taste transduction_Homo sapiens_hsa047420.86888449
76Morphine addiction_Homo sapiens_hsa050320.86834735
77Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.86680073
78Steroid biosynthesis_Homo sapiens_hsa001000.86366397
79ABC transporters_Homo sapiens_hsa020100.86067713
80Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.85913260
81Olfactory transduction_Homo sapiens_hsa047400.84735036
82Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.83971127
83Salivary secretion_Homo sapiens_hsa049700.82433632
84Dopaminergic synapse_Homo sapiens_hsa047280.80376097
85Fat digestion and absorption_Homo sapiens_hsa049750.78918656
86Thyroid hormone synthesis_Homo sapiens_hsa049180.78671903
87Insulin secretion_Homo sapiens_hsa049110.77445727
88Phosphatidylinositol signaling system_Homo sapiens_hsa040700.76447381
89Fanconi anemia pathway_Homo sapiens_hsa034600.76075621
90Retinol metabolism_Homo sapiens_hsa008300.75737680
91Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.75532738
92Biosynthesis of amino acids_Homo sapiens_hsa012300.73745954
93Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.72536868
94Ovarian steroidogenesis_Homo sapiens_hsa049130.72146488
95Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.70757692
96Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.68727881
97Arachidonic acid metabolism_Homo sapiens_hsa005900.68310216
98Regulation of autophagy_Homo sapiens_hsa041400.67803738
99Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.67514458
100beta-Alanine metabolism_Homo sapiens_hsa004100.67495342
101Hedgehog signaling pathway_Homo sapiens_hsa043400.67057781
102Fatty acid degradation_Homo sapiens_hsa000710.65200866
103Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.64833839
104Intestinal immune network for IgA production_Homo sapiens_hsa046720.64621481
105Estrogen signaling pathway_Homo sapiens_hsa049150.64153357
106Vascular smooth muscle contraction_Homo sapiens_hsa042700.62260096
107Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.62194975
108Primary immunodeficiency_Homo sapiens_hsa053400.62022892
109Pentose and glucuronate interconversions_Homo sapiens_hsa000400.60433201
110Purine metabolism_Homo sapiens_hsa002300.58925464
111Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.58179816
112Phenylalanine metabolism_Homo sapiens_hsa003600.57894250
113Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.56321897
114Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.55879198
115Rheumatoid arthritis_Homo sapiens_hsa053230.54665327
116Fatty acid metabolism_Homo sapiens_hsa012120.53993419
117Proteasome_Homo sapiens_hsa030500.53607220
118Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.52522536
119N-Glycan biosynthesis_Homo sapiens_hsa005100.51887052
120Inositol phosphate metabolism_Homo sapiens_hsa005620.51723580
121Glutathione metabolism_Homo sapiens_hsa004800.50766162
122Sulfur metabolism_Homo sapiens_hsa009200.50276932
123Folate biosynthesis_Homo sapiens_hsa007900.48794477
124Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.47735442
125Bile secretion_Homo sapiens_hsa049760.47304918
126Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.47001737
127Chemical carcinogenesis_Homo sapiens_hsa052040.45916926
128Fatty acid elongation_Homo sapiens_hsa000620.45359992
129Pancreatic secretion_Homo sapiens_hsa049720.45268296
130cGMP-PKG signaling pathway_Homo sapiens_hsa040220.44791588
131Pyrimidine metabolism_Homo sapiens_hsa002400.44094495
132Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.43854898
133cAMP signaling pathway_Homo sapiens_hsa040240.42707102
134Endocytosis_Homo sapiens_hsa041440.42051212
135Metabolic pathways_Homo sapiens_hsa011000.41532304
136Sphingolipid metabolism_Homo sapiens_hsa006000.41001128
137Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.40616587
138Oxidative phosphorylation_Homo sapiens_hsa001900.40119413
139mRNA surveillance pathway_Homo sapiens_hsa030150.39065851
140Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.38966584
141Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.38443165
142Asthma_Homo sapiens_hsa053100.37649641
143Nucleotide excision repair_Homo sapiens_hsa034200.37338940
144Basal cell carcinoma_Homo sapiens_hsa052170.36999840
145Steroid hormone biosynthesis_Homo sapiens_hsa001400.36504258
146Tyrosine metabolism_Homo sapiens_hsa003500.36314957
147Phagosome_Homo sapiens_hsa041450.36262139
148GABAergic synapse_Homo sapiens_hsa047270.31968513
149Cholinergic synapse_Homo sapiens_hsa047250.31941289
150Type I diabetes mellitus_Homo sapiens_hsa049400.30861371
151MAPK signaling pathway_Homo sapiens_hsa040100.29834040
152Long-term depression_Homo sapiens_hsa047300.29695760
153Non-homologous end-joining_Homo sapiens_hsa034500.27853474
154Fructose and mannose metabolism_Homo sapiens_hsa000510.26797337

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