ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	4.41295389
2	centriole replication (GO:0007099)	4.32780622
3	piRNA metabolic process (GO:0034587)	3.84162541
4	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.72639565
5	mast cell degranulation (GO:0043303)	3.60402114
6	mast cell activation involved in immune response (GO:0002279)	3.60402114
7	regulation of meiosis I (GO:0060631)	3.58793266
8	DNA methylation involved in gamete generation (GO:0043046)	3.57764227
9	positive regulation of interleukin-8 biosynthetic process (GO:0045416)	3.54855891
10	rRNA modification (GO:0000154)	3.54237089
11	mannosylation (GO:0097502)	3.46944599
12	neutrophil mediated immunity (GO:0002446)	3.44957045
13	positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)	3.38682311
14	pseudouridine synthesis (GO:0001522)	3.28013714
15	response to interferon-beta (GO:0035456)	3.19889997
16	ubiquinone biosynthetic process (GO:0006744)	3.18950351
17	centriole assembly (GO:0098534)	3.18104477
18	cellular extravasation (GO:0045123)	3.15225463
19	tryptophan metabolic process (GO:0006568)	3.11951287
20	negative regulation of growth of symbiont involved in interaction with host (GO:0044146)	3.10981154
21	modulation of growth of symbiont involved in interaction with host (GO:0044144)	3.10981154
22	regulation of growth of symbiont in host (GO:0044126)	3.10981154
23	negative regulation of growth of symbiont in host (GO:0044130)	3.10981154
24	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.06660910
25	water-soluble vitamin biosynthetic process (GO:0042364)	3.05416995
26	rRNA methylation (GO:0031167)	3.02262961
27	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.96494690
28	tryptophan catabolic process (GO:0006569)	2.96334533
29	indole-containing compound catabolic process (GO:0042436)	2.96334533
30	indolalkylamine catabolic process (GO:0046218)	2.96334533
31	positive regulation of histone H3-K4 methylation (GO:0051571)	2.94553120
32	rRNA catabolic process (GO:0016075)	2.93998975
33	synapsis (GO:0007129)	2.93404657
34	respiratory chain complex IV assembly (GO:0008535)	2.90842455
35	ribosome biogenesis (GO:0042254)	2.89139273
36	kynurenine metabolic process (GO:0070189)	2.86730670
37	regulation of mitotic spindle checkpoint (GO:1903504)	2.86686148
38	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.86686148
39	iron-sulfur cluster assembly (GO:0016226)	2.82331567
40	metallo-sulfur cluster assembly (GO:0031163)	2.82331567
41	killing of cells in other organism involved in symbiotic interaction (GO:0051883)	2.82106484
42	disruption of cells of other organism involved in symbiotic interaction (GO:0051818)	2.82106484
43	protein complex biogenesis (GO:0070271)	2.74628132
44	immunoglobulin mediated immune response (GO:0016064)	2.73721830
45	mast cell activation (GO:0045576)	2.72873050
46	regulation of centriole replication (GO:0046599)	2.72084121
47	ubiquinone metabolic process (GO:0006743)	2.71773538
48	mitochondrial respiratory chain complex assembly (GO:0033108)	2.70726858
49	histone H2A acetylation (GO:0043968)	2.69752128
50	positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)	2.69270728
51	male meiosis (GO:0007140)	2.68381104
52	positive regulation of B cell differentiation (GO:0045579)	2.67731495
53	phosphorylated carbohydrate dephosphorylation (GO:0046838)	2.66522384
54	inositol phosphate dephosphorylation (GO:0046855)	2.66522384
55	mitotic sister chromatid cohesion (GO:0007064)	2.66109940
56	double-strand break repair via homologous recombination (GO:0000724)	2.65629378
57	establishment of protein localization to Golgi (GO:0072600)	2.63969512
58	quinone biosynthetic process (GO:1901663)	2.63523394
59	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.62664674
60	NADH dehydrogenase complex assembly (GO:0010257)	2.62664674
61	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.62664674
62	recombinational repair (GO:0000725)	2.61530483
63	postreplication repair (GO:0006301)	2.61095623
64	regulation of chemokine biosynthetic process (GO:0045073)	2.54744921
65	DNA synthesis involved in DNA repair (GO:0000731)	2.54716029
66	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.53922813
67	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	2.53730712
68	cellular response to interferon-beta (GO:0035458)	2.52968951
69	positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO	2.52382211
70	regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)	2.52382211
71	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.49907290
72	translesion synthesis (GO:0019985)	2.49526694
73	regulation of histone H3-K4 methylation (GO:0051569)	2.48259185
74	ncRNA catabolic process (GO:0034661)	2.48190001
75	positive regulation of T cell cytokine production (GO:0002726)	2.47971817
76	regulation of mitochondrial translation (GO:0070129)	2.47312725
77	cellular ketone body metabolic process (GO:0046950)	2.46348004
78	fucose catabolic process (GO:0019317)	2.45133795
79	L-fucose metabolic process (GO:0042354)	2.45133795
80	L-fucose catabolic process (GO:0042355)	2.45133795
81	tRNA aminoacylation for protein translation (GO:0006418)	2.44868351
82	kinetochore organization (GO:0051383)	2.44519544
83	regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)	2.44313212
84	positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)	2.44313212
85	platelet dense granule organization (GO:0060155)	2.43959816
86	tRNA modification (GO:0006400)	2.41522294
87	cytochrome complex assembly (GO:0017004)	2.40675716
88	tRNA processing (GO:0008033)	2.40397072
89	protein targeting to Golgi (GO:0000042)	2.39603001
90	regulation of cilium movement (GO:0003352)	2.39519554
91	sleep (GO:0030431)	2.39449301
92	DNA modification (GO:0006304)	2.39011973
93	amino acid activation (GO:0043038)	2.38238432
94	tRNA aminoacylation (GO:0043039)	2.38238432
95	regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)	2.37994380
96	positive regulation of megakaryocyte differentiation (GO:0045654)	2.37536481
97	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.37101318
98	myeloid leukocyte mediated immunity (GO:0002444)	2.36660221
99	mitochondrial RNA metabolic process (GO:0000959)	2.35459655
100	transcription from RNA polymerase III promoter (GO:0006383)	2.34986089

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.05437268
2	E2F7_22180533_ChIP-Seq_HELA_Human	3.92265802
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.48951803
4	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	3.28741574
5	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.86017546
6	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.77713048
7	VDR_23849224_ChIP-Seq_CD4+_Human	2.73101683
8	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.64701279
9	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.57062423
10	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.54689137
11	ELK1_19687146_ChIP-ChIP_HELA_Human	2.54495391
12	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.53622657
13	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.53601745
14	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.47908527
15	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	2.42578126
16	VDR_22108803_ChIP-Seq_LS180_Human	2.41555987
17	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.38433984
18	CIITA_25753668_ChIP-Seq_RAJI_Human	2.37134239
19	FOXP3_21729870_ChIP-Seq_TREG_Human	2.23131531
20	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.08125362
21	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.00490772
22	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.98253817
23	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.89196618
24	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.86843171
25	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.81835898
26	ZNF274_21170338_ChIP-Seq_K562_Hela	1.80886521
27	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.79515601
28	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.74804325
29	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.70695482
30	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.69662460
31	GABP_19822575_ChIP-Seq_HepG2_Human	1.68443610
32	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.65904513
33	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.60183429
34	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.59374121
35	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.59302920
36	DCP1A_22483619_ChIP-Seq_HELA_Human	1.57233279
37	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.56892139
38	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.56101688
39	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.50161264
40	KDM5A_27292631_Chip-Seq_BREAST_Human	1.46493134
41	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.46385008
42	MYB_26560356_Chip-Seq_TH2_Human	1.44013225
43	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.39220467
44	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.39102333
45	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.39012043
46	IRF1_19129219_ChIP-ChIP_H3396_Human	1.38985831
47	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.38925887
48	EWS_26573619_Chip-Seq_HEK293_Human	1.35498637
49	SCL_19346495_ChIP-Seq_HPC-7_Human	1.35002682
50	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.34926643
51	SPI1_23547873_ChIP-Seq_NB4_Human	1.34751778
52	MYC_18940864_ChIP-ChIP_HL60_Human	1.32103017
53	TTF2_22483619_ChIP-Seq_HELA_Human	1.27444546
54	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.26936357
55	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.26575348
56	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	1.25704075
57	TP53_22573176_ChIP-Seq_HFKS_Human	1.24737099
58	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.20719799
59	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.19687220
60	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.18768335
61	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.16534263
62	GATA3_26560356_Chip-Seq_TH2_Human	1.16530324
63	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.16267377
64	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.15808605
65	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.14617932
66	MYB_26560356_Chip-Seq_TH1_Human	1.12622374
67	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.10137819
68	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.09305187
69	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.07367647
70	CBP_20019798_ChIP-Seq_JUKART_Human	1.07367647
71	FUS_26573619_Chip-Seq_HEK293_Human	1.07125245
72	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.06903638
73	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.04944526
74	XRN2_22483619_ChIP-Seq_HELA_Human	1.03947261
75	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.03915587
76	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.01527060
77	ER_23166858_ChIP-Seq_MCF-7_Human	0.98953976
78	RBPJ_21746931_ChIP-Seq_IB4_Human	0.97369322
79	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	0.96662431
80	MYC_19079543_ChIP-ChIP_MESCs_Mouse	0.94071248
81	GATA3_26560356_Chip-Seq_TH1_Human	0.93956082
82	TAF2_19829295_ChIP-Seq_ESCs_Human	0.92865390
83	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.91256293
84	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.91156880
85	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	0.91145272
86	E2F1_18555785_ChIP-Seq_MESCs_Mouse	0.91106068
87	ETV1_20927104_ChIP-Seq_GIST48_Human	0.90207285
88	GFI1B_20887958_ChIP-Seq_HPC-7_Mouse	0.89929815
89	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	0.89242088
90	NELFA_20434984_ChIP-Seq_ESCs_Mouse	0.88906884
91	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.88754460
92	PCGF2_27294783_Chip-Seq_ESCs_Mouse	0.88381780
93	TFEB_21752829_ChIP-Seq_HELA_Human	0.87434329
94	GATA3_27048872_Chip-Seq_THYMUS_Human	0.87007724
95	SALL4_22934838_ChIP-ChIP_CD34+_Human	0.86491043
96	MYCN_18555785_ChIP-Seq_MESCs_Mouse	0.86166859
97	HOXB7_26014856_ChIP-Seq_BT474_Human	0.85096678
98	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.85091520
99	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	0.84978255
100	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	0.83341038

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008057_abnormal_DNA_replication	3.39175081
2	MP0008877_abnormal_DNA_methylation	3.30446605
3	MP0008995_early_reproductive_senescence	3.21425955
4	MP0008058_abnormal_DNA_repair	2.92025707
5	MP0009697_abnormal_copulation	2.75663141
6	MP0001545_abnormal_hematopoietic_system	2.51683128
7	MP0005397_hematopoietic_system_phenotyp	2.51683128
8	MP0006292_abnormal_olfactory_placode	2.37323405
9	MP0003693_abnormal_embryo_hatching	2.30366171
10	MP0002166_altered_tumor_susceptibility	2.27102773
11	MP0001835_abnormal_antigen_presentation	2.10786275
12	MP0002396_abnormal_hematopoietic_system	2.08206868
13	MP0003195_calcinosis	2.05262264
14	MP0005671_abnormal_response_to	2.00122185
15	MP0005075_abnormal_melanosome_morpholog	1.95509373
16	MP0004147_increased_porphyrin_level	1.95062676
17	MP0002006_tumorigenesis	1.92775412
18	MP0004043_abnormal_pH_regulation	1.89571086
19	MP0010094_abnormal_chromosome_stability	1.89007978
20	MP0003111_abnormal_nucleus_morphology	1.84095283
21	MP0003656_abnormal_erythrocyte_physiolo	1.80775989
22	MP0006036_abnormal_mitochondrial_physio	1.80548560
23	MP0003786_premature_aging	1.80509605
24	MP0005410_abnormal_fertilization	1.72442845
25	MP0002736_abnormal_nociception_after	1.68023242
26	MP0003806_abnormal_nucleotide_metabolis	1.64538420
27	MP0006035_abnormal_mitochondrial_morpho	1.62546648
28	MP0005646_abnormal_pituitary_gland	1.57959861
29	MP0004957_abnormal_blastocyst_morpholog	1.52336745
30	MP0010307_abnormal_tumor_latency	1.48320445
31	MP0003718_maternal_effect	1.47668696
32	MP0001968_abnormal_touch/_nociception	1.46844640
33	MP0001800_abnormal_humoral_immune	1.43595962
34	MP0003252_abnormal_bile_duct	1.40376618
35	MP0001929_abnormal_gametogenesis	1.38656969
36	MP0008872_abnormal_physiological_respon	1.38528889
37	MP0001873_stomach_inflammation	1.37497970
38	MP0002398_abnormal_bone_marrow	1.34768694
39	MP0002722_abnormal_immune_system	1.30246176
40	MP0000465_gastrointestinal_hemorrhage	1.30015058
41	MP0009785_altered_susceptibility_to	1.28844791
42	MP0000689_abnormal_spleen_morphology	1.28085001
43	MP0002132_abnormal_respiratory_system	1.26910865
44	MP0002095_abnormal_skin_pigmentation	1.26234091
45	MP0003950_abnormal_plasma_membrane	1.25302107
46	MP0003172_abnormal_lysosome_physiology	1.24296059
47	MP0002723_abnormal_immune_serum	1.23622687
48	MP0002420_abnormal_adaptive_immunity	1.20066508
49	MP0001853_heart_inflammation	1.18646540
50	MP0001819_abnormal_immune_cell	1.18613976
51	MP0002928_abnormal_bile_duct	1.18584336
52	MP0005000_abnormal_immune_tolerance	1.18451323
53	MP0005025_abnormal_response_to	1.16517218
54	MP0005174_abnormal_tail_pigmentation	1.16461729
55	MP0003436_decreased_susceptibility_to	1.15355860
56	MP0002452_abnormal_antigen_presenting	1.14681972
57	MP0002019_abnormal_tumor_incidence	1.14423277
58	MP0002009_preneoplasia	1.14008676
59	MP0000716_abnormal_immune_system	1.12497974
60	MP0006072_abnormal_retinal_apoptosis	1.11736088
61	MP0003077_abnormal_cell_cycle	1.11689745
62	MP0000703_abnormal_thymus_morphology	1.09990417
63	MP0002419_abnormal_innate_immunity	1.09393559
64	MP0008873_increased_physiological_sensi	1.07930994
65	MP0003763_abnormal_thymus_physiology	1.06966626
66	MP0002139_abnormal_hepatobiliary_system	1.05474082
67	MP0005551_abnormal_eye_electrophysiolog	1.04558893
68	MP0002148_abnormal_hypersensitivity_rea	1.02923569
69	MP0002429_abnormal_blood_cell	1.01169042
70	MP0000372_irregular_coat_pigmentation	1.00481382
71	MP0005636_abnormal_mineral_homeostasis	0.99128596
72	MP0008932_abnormal_embryonic_tissue	0.97614421
73	MP0003698_abnormal_male_reproductive	0.96791854
74	MP0005379_endocrine/exocrine_gland_phen	0.96368170
75	MP0002210_abnormal_sex_determination	0.95594059
76	MP0009764_decreased_sensitivity_to	0.93638945
77	MP0000685_abnormal_immune_system	0.92922834
78	MP0005464_abnormal_platelet_physiology	0.92686481
79	MP0000653_abnormal_sex_gland	0.90030151
80	MP0005389_reproductive_system_phenotype	0.88224035
81	MP0001764_abnormal_homeostasis	0.88025862
82	MP0004782_abnormal_surfactant_physiolog	0.87815450
83	MP0001119_abnormal_female_reproductive	0.87178886
84	MP0001145_abnormal_male_reproductive	0.86800142
85	MP0009333_abnormal_splenocyte_physiolog	0.86633826
86	MP0001986_abnormal_taste_sensitivity	0.86608415
87	MP0000358_abnormal_cell_content/	0.86168659
88	MP0008007_abnormal_cellular_replicative	0.85166607
89	MP0000427_abnormal_hair_cycle	0.84421213
90	MP0002163_abnormal_gland_morphology	0.83647935
91	MP0008469_abnormal_protein_level	0.83408264
92	MP0005220_abnormal_exocrine_pancreas	0.81655749
93	MP0002876_abnormal_thyroid_physiology	0.81484504
94	MP0003787_abnormal_imprinting	0.81346690
95	MP0005387_immune_system_phenotype	0.81266781
96	MP0001790_abnormal_immune_system	0.81266781
97	MP0001919_abnormal_reproductive_system	0.79434326
98	MP0001661_extended_life_span	0.77283673
99	MP0005266_abnormal_metabolism	0.75344316
100	MP0010329_abnormal_lipoprotein_level	0.73757766

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Thrombocytosis (HP:0001894)	4.20623837
2	Type I transferrin isoform profile (HP:0003642)	3.82078182
3	Volvulus (HP:0002580)	3.68851090
4	Pancreatic cysts (HP:0001737)	3.28680891
5	Hepatocellular necrosis (HP:0001404)	3.21404099
6	Chromsome breakage (HP:0040012)	3.18505964
7	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.99959619
8	Abnormal protein N-linked glycosylation (HP:0012347)	2.99959619
9	Abnormal protein glycosylation (HP:0012346)	2.99959619
10	Abnormal glycosylation (HP:0012345)	2.99959619
11	Increased CSF lactate (HP:0002490)	2.97191872
12	B lymphocytopenia (HP:0010976)	2.89885279
13	Abnormality of the prostate (HP:0008775)	2.89521223
14	Abnormality of DNA repair (HP:0003254)	2.89124722
15	Hepatic necrosis (HP:0002605)	2.88368578
16	Renal cortical cysts (HP:0000803)	2.86950858
17	Mitochondrial inheritance (HP:0001427)	2.85327505
18	Abnormality of B cell number (HP:0010975)	2.85052927
19	Acute necrotizing encephalopathy (HP:0006965)	2.80862254
20	Granulocytopenia (HP:0001913)	2.80368028
21	Eosinophilia (HP:0001880)	2.78062229
22	Pancreatic fibrosis (HP:0100732)	2.77107572
23	Progressive macrocephaly (HP:0004481)	2.76921294
24	Abnormality of the heme biosynthetic pathway (HP:0010472)	2.63507413
25	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.63389716
26	Abnormal number of erythroid precursors (HP:0012131)	2.61123306
27	Abnormality of the renal cortex (HP:0011035)	2.60725322
28	Abnormal mitochondria in muscle tissue (HP:0008316)	2.59009579
29	Severe combined immunodeficiency (HP:0004430)	2.55051920
30	Molar tooth sign on MRI (HP:0002419)	2.52473421
31	Abnormality of midbrain morphology (HP:0002418)	2.52473421
32	Large for gestational age (HP:0001520)	2.50170259
33	True hermaphroditism (HP:0010459)	2.44138704
34	Abnormality of eosinophils (HP:0001879)	2.42518501
35	Abnormality of male internal genitalia (HP:0000022)	2.40616258
36	Acute encephalopathy (HP:0006846)	2.39954512
37	Increased serum lactate (HP:0002151)	2.39903854
38	Protruding tongue (HP:0010808)	2.39499581
39	Pancreatic islet-cell hyperplasia (HP:0004510)	2.30763891
40	Chronic hepatic failure (HP:0100626)	2.30612932
41	Acute myeloid leukemia (HP:0004808)	2.28132043
42	Nephronophthisis (HP:0000090)	2.27930795
43	Poikiloderma (HP:0001029)	2.23935617
44	Elevated erythrocyte sedimentation rate (HP:0003565)	2.23353988
45	Abnormality of the ileum (HP:0001549)	2.19968093
46	Pancytopenia (HP:0001876)	2.19967051
47	Abnormality of chromosome stability (HP:0003220)	2.16879900
48	Acute lymphatic leukemia (HP:0006721)	2.16152372
49	Abnormality of cells of the erythroid lineage (HP:0012130)	2.14551051
50	IgG deficiency (HP:0004315)	2.14342009
51	Abnormality of the renal medulla (HP:0100957)	2.09010273
52	Entropion (HP:0000621)	2.08490834
53	Stomach cancer (HP:0012126)	2.08032592
54	Poikilocytosis (HP:0004447)	2.07301403
55	Increased serum pyruvate (HP:0003542)	2.04535847
56	Nephroblastoma (Wilms tumor) (HP:0002667)	2.02816118
57	Aplasia/Hypoplasia of the thymus (HP:0010515)	2.01519609
58	Cerebral edema (HP:0002181)	2.01368493
59	Alveolar cell carcinoma (HP:0006519)	2.01014518
60	Neutropenia (HP:0001875)	2.00762101
61	Duplicated collecting system (HP:0000081)	2.00152539
62	Abnormality of T cell physiology (HP:0011840)	1.98370051
63	Aplastic anemia (HP:0001915)	1.96452982
64	Combined immunodeficiency (HP:0005387)	1.95239241
65	Neoplasm of the adrenal cortex (HP:0100641)	1.94743876
66	Progressive microcephaly (HP:0000253)	1.92978318
67	Embryonal renal neoplasm (HP:0011794)	1.92730992
68	Reduced antithrombin III activity (HP:0001976)	1.91353208
69	Thyroiditis (HP:0100646)	1.90730964
70	Hypoproteinemia (HP:0003075)	1.89960956
71	Myelodysplasia (HP:0002863)	1.88548034
72	Tinnitus (HP:0000360)	1.88380290
73	Reticulocytosis (HP:0001923)	1.88312220
74	Leukocytosis (HP:0001974)	1.88011815
75	Congenital, generalized hypertrichosis (HP:0004540)	1.85077214
76	Lactic acidosis (HP:0003128)	1.84373242
77	Abnormality of the pons (HP:0007361)	1.84157077
78	Pulmonary fibrosis (HP:0002206)	1.83447394
79	Short middle phalanx of the 5th finger (HP:0004220)	1.81220142
80	Brushfield spots (HP:0001088)	1.80837627
81	Microvesicular hepatic steatosis (HP:0001414)	1.80457058
82	Spontaneous abortion (HP:0005268)	1.77174157
83	Abnormality of T cells (HP:0002843)	1.76897919
84	Fair hair (HP:0002286)	1.75198072
85	Abnormality of the preputium (HP:0100587)	1.74280478
86	Hypoplasia of the pons (HP:0012110)	1.73897446
87	Sloping forehead (HP:0000340)	1.73157174
88	Duodenal stenosis (HP:0100867)	1.73146241
89	Small intestinal stenosis (HP:0012848)	1.73146241
90	Capillary hemangiomas (HP:0005306)	1.72642297
91	Abnormality of the renal collecting system (HP:0004742)	1.71595290
92	Squamous cell carcinoma (HP:0002860)	1.71566330
93	Meckel diverticulum (HP:0002245)	1.69403296
94	Neoplasm of the tracheobronchial system (HP:0100552)	1.67885728
95	Hypertensive crisis (HP:0100735)	1.66054554
96	Abnormality of reticulocytes (HP:0004312)	1.65995008
97	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.64898814
98	Acanthocytosis (HP:0001927)	1.62998579
99	Hypoplasia of the thymus (HP:0000778)	1.62456501
100	Optic disc pallor (HP:0000543)	1.62445861

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.14604930
2	NUAK1	3.30821689
3	TAOK3	3.26497045
4	BMPR2	3.23996202
5	TNIK	3.01364346
6	ZAK	2.94725222
7	MST4	2.90213693
8	SCYL2	2.82067680
9	TXK	2.57974733
10	MAP4K2	2.46992270
11	PLK4	2.23565065
12	RIPK4	2.11355405
13	PIK3CG	2.05596301
14	TEC	2.04213748
15	EIF2AK3	1.75645103
16	WNK4	1.69696114
17	KDR	1.68376462
18	VRK2	1.65233567
19	TLK1	1.63786637
20	IKBKB	1.54217711
21	KIT	1.51418535
22	CDK8	1.45221201
23	TTK	1.40813791
24	SIK2	1.40132102
25	BRSK2	1.36051219
26	JAK3	1.31653151
27	MAP4K1	1.30352610
28	FES	1.28789683
29	ATR	1.24633992
30	BUB1	1.23044112
31	INSRR	1.21565545
32	MKNK2	1.21304167
33	OXSR1	1.20546422
34	CDC7	1.18211387
35	PDK2	1.12034679
36	IKBKE	1.10541899
37	SRPK1	1.06738155
38	MAP3K12	1.06158295
39	ADRBK2	1.05679774
40	CDK3	1.03074923
41	MAP3K14	0.96305674
42	TBK1	0.95685997
43	CHEK2	0.95015562
44	SYK	0.94079799
45	LYN	0.89642324
46	STK3	0.83372020
47	BMPR1B	0.81122231
48	MKNK1	0.79149645
49	VRK1	0.78878828
50	NEK2	0.75841438
51	TESK2	0.75235093
52	STK4	0.72908434
53	GRK1	0.72487666
54	CDK19	0.72148573
55	ATM	0.70758504
56	EIF2AK1	0.70292969
57	STK16	0.69823225
58	ITK	0.68782786
59	NLK	0.65821462
60	MARK3	0.64616238
61	MAP3K2	0.63643594
62	RPS6KB2	0.62780760
63	FLT3	0.62426333
64	RPS6KA5	0.62239850
65	CHEK1	0.61629056
66	CDK4	0.59362179
67	BTK	0.58796026
68	BCKDK	0.57787471
69	PLK2	0.55430991
70	LCK	0.55178645
71	PLK1	0.54477506
72	CSF1R	0.53392394
73	EIF2AK2	0.51778363
74	CHUK	0.50058474
75	MUSK	0.48361908
76	TRPM7	0.47017700
77	CCNB1	0.45226868
78	PRKCI	0.45211529
79	BRD4	0.44031304
80	TNK2	0.42950092
81	DMPK	0.42559219
82	MAP3K7	0.42490147
83	PRKAA2	0.42473648
84	STK10	0.42331001
85	ABL1	0.42207354
86	GRK6	0.42011894
87	STK39	0.41793050
88	NME1	0.41658973
89	AURKB	0.40937374
90	RPS6KA4	0.40692425
91	CLK1	0.38980827
92	PBK	0.38111371
93	NME2	0.37883854
94	STK38L	0.36972716
95	PRKCQ	0.36918058
96	IRAK1	0.36862624
97	CDK7	0.36807123
98	MATK	0.36677658
99	PIM1	0.35406701
100	CSNK2A2	0.34034444

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Asthma_Homo sapiens_hsa05310	3.90058381
2	Intestinal immune network for IgA production_Homo sapiens_hsa04672	3.12173840
3	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.91181586
4	Allograft rejection_Homo sapiens_hsa05330	2.80766301
5	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.76291945
6	Graft-versus-host disease_Homo sapiens_hsa05332	2.75727532
7	Homologous recombination_Homo sapiens_hsa03440	2.73449281
8	Proteasome_Homo sapiens_hsa03050	2.63940620
9	One carbon pool by folate_Homo sapiens_hsa00670	2.42671329
10	Type I diabetes mellitus_Homo sapiens_hsa04940	2.39399218
11	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	2.36059812
12	RNA polymerase_Homo sapiens_hsa03020	2.20246093
13	Non-homologous end-joining_Homo sapiens_hsa03450	2.07691303
14	Oxidative phosphorylation_Homo sapiens_hsa00190	1.98915462
15	DNA replication_Homo sapiens_hsa03030	1.98846471
16	Fanconi anemia pathway_Homo sapiens_hsa03460	1.97701037
17	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.91321772
18	Primary immunodeficiency_Homo sapiens_hsa05340	1.87174606
19	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.85319889
20	Antigen processing and presentation_Homo sapiens_hsa04612	1.75081560
21	Base excision repair_Homo sapiens_hsa03410	1.72307917
22	Protein export_Homo sapiens_hsa03060	1.68317119
23	Parkinsons disease_Homo sapiens_hsa05012	1.65230758
24	Mismatch repair_Homo sapiens_hsa03430	1.57891385
25	RNA transport_Homo sapiens_hsa03013	1.56675792
26	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.54598475
27	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.53791912
28	Leishmaniasis_Homo sapiens_hsa05140	1.53744500
29	Nucleotide excision repair_Homo sapiens_hsa03420	1.48067982
30	Butanoate metabolism_Homo sapiens_hsa00650	1.46005491
31	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.44918824
32	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.43810992
33	Spliceosome_Homo sapiens_hsa03040	1.42999890
34	RNA degradation_Homo sapiens_hsa03018	1.41227677
35	Selenocompound metabolism_Homo sapiens_hsa00450	1.41052732
36	Basal transcription factors_Homo sapiens_hsa03022	1.40289963
37	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.27999265
38	Rheumatoid arthritis_Homo sapiens_hsa05323	1.24280239
39	Ribosome_Homo sapiens_hsa03010	1.23744444
40	Huntingtons disease_Homo sapiens_hsa05016	1.15156546
41	Herpes simplex infection_Homo sapiens_hsa05168	1.13741730
42	Pyrimidine metabolism_Homo sapiens_hsa00240	1.12553947
43	Viral myocarditis_Homo sapiens_hsa05416	1.11972967
44	Phototransduction_Homo sapiens_hsa04744	1.09323049
45	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.00201350
46	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.95389311
47	Alzheimers disease_Homo sapiens_hsa05010	0.89448761
48	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.89183052
49	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.85524715
50	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.81223111
51	Peroxisome_Homo sapiens_hsa04146	0.78678601
52	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.78448251
53	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.78043613
54	Purine metabolism_Homo sapiens_hsa00230	0.77850694
55	Tryptophan metabolism_Homo sapiens_hsa00380	0.77011964
56	Regulation of autophagy_Homo sapiens_hsa04140	0.76736466
57	mRNA surveillance pathway_Homo sapiens_hsa03015	0.74260313
58	Lysine degradation_Homo sapiens_hsa00310	0.73173689
59	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.71981534
60	Influenza A_Homo sapiens_hsa05164	0.67925169
61	Fatty acid metabolism_Homo sapiens_hsa01212	0.67533790
62	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.66145106
63	Olfactory transduction_Homo sapiens_hsa04740	0.65280873
64	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.64059290
65	Propanoate metabolism_Homo sapiens_hsa00640	0.63841123
66	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.57402550
67	Toxoplasmosis_Homo sapiens_hsa05145	0.56221474
68	Measles_Homo sapiens_hsa05162	0.55898899
69	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.54986495
70	Cell cycle_Homo sapiens_hsa04110	0.52076783
71	Glutathione metabolism_Homo sapiens_hsa00480	0.50120658
72	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.48953302
73	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.46726332
74	Pyruvate metabolism_Homo sapiens_hsa00620	0.46300108
75	Fatty acid elongation_Homo sapiens_hsa00062	0.46190119
76	Nitrogen metabolism_Homo sapiens_hsa00910	0.44388020
77	Tuberculosis_Homo sapiens_hsa05152	0.44223106
78	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.44220373
79	Metabolic pathways_Homo sapiens_hsa01100	0.41814569
80	Linoleic acid metabolism_Homo sapiens_hsa00591	0.41375735
81	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.39452357
82	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.38749268
83	Legionellosis_Homo sapiens_hsa05134	0.37519032
84	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.34430480
85	p53 signaling pathway_Homo sapiens_hsa04115	0.32866288
86	Folate biosynthesis_Homo sapiens_hsa00790	0.32550840
87	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.32344199
88	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.32054063
89	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.29936592
90	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.26757994
91	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.26181615
92	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.25663624
93	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.25525468
94	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.24140343
95	Fatty acid degradation_Homo sapiens_hsa00071	0.23843594
96	African trypanosomiasis_Homo sapiens_hsa05143	0.23220739
97	ABC transporters_Homo sapiens_hsa02010	0.22048023
98	Chemical carcinogenesis_Homo sapiens_hsa05204	0.21626776
99	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.21569041
100	HTLV-I infection_Homo sapiens_hsa05166	0.21368121

LRRFIP1P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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