LRRIQ1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1motile cilium assembly (GO:0044458)9.74355501
2fusion of sperm to egg plasma membrane (GO:0007342)8.70860101
3ventricular system development (GO:0021591)8.37431557
4cell wall macromolecule catabolic process (GO:0016998)8.00166972
5cell wall macromolecule metabolic process (GO:0044036)8.00166972
6multicellular organism reproduction (GO:0032504)7.25641384
7sperm motility (GO:0030317)6.98820869
8GTP biosynthetic process (GO:0006183)6.83494686
9acrosome assembly (GO:0001675)6.82518309
10plasma membrane fusion (GO:0045026)6.73894708
11nucleoside diphosphate phosphorylation (GO:0006165)6.55037043
12intraciliary transport (GO:0042073)6.37597439
13sperm-egg recognition (GO:0035036)6.30790301
14left/right axis specification (GO:0070986)6.18967527
15acrosome reaction (GO:0007340)6.02804938
16UTP biosynthetic process (GO:0006228)5.95793357
17reproduction (GO:0000003)5.82439525
18regulation of cilium movement (GO:0003352)5.74750209
19cilium organization (GO:0044782)5.62295269
20binding of sperm to zona pellucida (GO:0007339)5.59513177
21cell-cell recognition (GO:0009988)5.56730869
22spermatid development (GO:0007286)5.55063393
23UTP metabolic process (GO:0046051)5.45734457
24male meiosis (GO:0007140)5.39995014
25cilium assembly (GO:0042384)5.30765044
26single fertilization (GO:0007338)5.26973817
27piRNA metabolic process (GO:0034587)5.04071854
28cilium morphogenesis (GO:0060271)4.85391254
29microtubule bundle formation (GO:0001578)4.82139987
30negative regulation of inclusion body assembly (GO:0090084)4.68485355
31cellular component assembly involved in morphogenesis (GO:0010927)4.67617192
32microtubule-based movement (GO:0007018)4.58753891
33protein localization to cilium (GO:0061512)4.57439525
34guanosine-containing compound biosynthetic process (GO:1901070)4.43904194
35fertilization (GO:0009566)4.42335345
36CTP metabolic process (GO:0046036)4.39285023
37CTP biosynthetic process (GO:0006241)4.39285023
38male meiosis I (GO:0007141)4.33466002
39synaptonemal complex organization (GO:0070193)4.26403398
40spermatid nucleus differentiation (GO:0007289)4.14362512
41regulation of inclusion body assembly (GO:0090083)4.11446554
42pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.91251359
43behavioral response to nicotine (GO:0035095)3.86321756
44sperm capacitation (GO:0048240)3.84585541
45microtubule severing (GO:0051013)3.84139432
46spermatogenesis (GO:0007283)3.69903045
47male gamete generation (GO:0048232)3.68266007
48pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)3.66491059
49axon ensheathment in central nervous system (GO:0032291)3.65269998
50central nervous system myelination (GO:0022010)3.65269998
51otic vesicle formation (GO:0030916)3.61952146
52cell projection assembly (GO:0030031)3.59615906
53pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.58501114
54brain morphogenesis (GO:0048854)3.54410660
55substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.53314474
56substrate-independent telencephalic tangential migration (GO:0021826)3.53314474
57nucleotide phosphorylation (GO:0046939)3.50794943
58calcium ion-dependent exocytosis (GO:0017156)3.49615164
59synaptonemal complex assembly (GO:0007130)3.49514671
60protein polyglutamylation (GO:0018095)3.48906697
61gamete generation (GO:0007276)3.45226875
62centriole assembly (GO:0098534)3.40259580
63left/right pattern formation (GO:0060972)3.39672265
64meiosis I (GO:0007127)3.39452521
65centriole replication (GO:0007099)3.38719091
66neuron fate determination (GO:0048664)3.38069407
67regulation of microtubule-based movement (GO:0060632)3.35021632
68meiotic cell cycle (GO:0051321)3.26902833
69pyrimidine nucleobase catabolic process (GO:0006208)3.26744152
70retinal rod cell development (GO:0046548)3.24155805
71cell recognition (GO:0008037)3.22450415
72DNA methylation involved in gamete generation (GO:0043046)3.17485973
73lung epithelium development (GO:0060428)3.14663139
74appendage development (GO:0048736)3.11067106
75limb development (GO:0060173)3.11067106
76pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.09655643
77retinal ganglion cell axon guidance (GO:0031290)3.08216120
78nucleoside diphosphate metabolic process (GO:0009132)3.07227550
79germ cell development (GO:0007281)3.00040632
80somite development (GO:0061053)2.98976276
81microtubule polymerization or depolymerization (GO:0031109)2.97572870
82cellular process involved in reproduction in multicellular organism (GO:0022412)2.94331682
83establishment of planar polarity (GO:0001736)2.91850532
84establishment of tissue polarity (GO:0007164)2.91850532
85determination of left/right symmetry (GO:0007368)2.91719982
86neuronal stem cell maintenance (GO:0097150)2.90587240
87meiotic nuclear division (GO:0007126)2.86152787
88presynaptic membrane organization (GO:0097090)2.83034877
89negative regulation of oligodendrocyte differentiation (GO:0048715)2.80683829
90presynaptic membrane assembly (GO:0097105)2.79815728
91determination of bilateral symmetry (GO:0009855)2.79101009
92lateral sprouting from an epithelium (GO:0060601)2.78298647
93photoreceptor cell maintenance (GO:0045494)2.76915630
94regulation of collateral sprouting (GO:0048670)2.76738178
95regulation of pigment cell differentiation (GO:0050932)2.75896016
96limb bud formation (GO:0060174)2.75243686
97lateral ventricle development (GO:0021670)2.75106790
98multicellular organismal reproductive process (GO:0048609)2.73290932
99specification of symmetry (GO:0009799)2.73150973
100postsynaptic membrane organization (GO:0001941)2.72692004
101regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.72481139
102auditory behavior (GO:0031223)2.69291191
103kidney morphogenesis (GO:0060993)2.65931712
104smoothened signaling pathway (GO:0007224)2.65583705
105transmission of nerve impulse (GO:0019226)2.64675286
106negative regulation of astrocyte differentiation (GO:0048712)2.61440296
107organelle assembly (GO:0070925)2.59404644
108microtubule-based process (GO:0007017)2.57050786
109axonal fasciculation (GO:0007413)2.56681223
110neural tube formation (GO:0001841)2.56289185
111nucleobase catabolic process (GO:0046113)2.54985895
112microtubule depolymerization (GO:0007019)2.54652374
113establishment of protein localization to mitochondrial membrane (GO:0090151)2.53766681
114photoreceptor cell differentiation (GO:0046530)2.53645480
115eye photoreceptor cell differentiation (GO:0001754)2.53645480
116organic cation transport (GO:0015695)2.52236180
117base-excision repair, AP site formation (GO:0006285)2.51585828
118positive regulation of gastrulation (GO:2000543)2.49157140
119response to pheromone (GO:0019236)2.48601942
120nonmotile primary cilium assembly (GO:0035058)2.46483398
121cell proliferation in forebrain (GO:0021846)2.46354942
122mechanosensory behavior (GO:0007638)2.46196538
123organelle disassembly (GO:1903008)2.46058575
124regulation of smoothened signaling pathway (GO:0008589)2.46011644
125pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.45983886
126protein localization to synapse (GO:0035418)2.45064588
127photoreceptor cell development (GO:0042461)2.44725361
128retinal cone cell development (GO:0046549)2.42662354
129spinal cord motor neuron differentiation (GO:0021522)2.41859691
130chromosome organization involved in meiosis (GO:0070192)2.41714051
131forebrain neuron differentiation (GO:0021879)2.41575547
132dorsal/ventral pattern formation (GO:0009953)2.41503225
133protein refolding (GO:0042026)2.41476107
134purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.40479790
135negative regulation of glial cell differentiation (GO:0045686)2.40015261
136retina layer formation (GO:0010842)2.39537235
137multicellular organismal aging (GO:0010259)2.38360302
138response to auditory stimulus (GO:0010996)2.37621421
139sequestering of actin monomers (GO:0042989)2.35983803
140microtubule-based transport (GO:0010970)2.34665622
141nephron epithelium morphogenesis (GO:0072088)2.33638217
142nephron tubule morphogenesis (GO:0072078)2.33638217
143lactate metabolic process (GO:0006089)2.33479917
144purine nucleoside triphosphate biosynthetic process (GO:0009145)2.33008364
145heart looping (GO:0001947)2.32126084
146hindbrain development (GO:0030902)2.31819308
147mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.31223285
148cornea development in camera-type eye (GO:0061303)2.30046959
149negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.29421827
150deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.28609452
151energy coupled proton transport, down electrochemical gradient (GO:0015985)2.28487159
152ATP synthesis coupled proton transport (GO:0015986)2.28487159
153protein K11-linked deubiquitination (GO:0035871)2.25344729
154ADP metabolic process (GO:0046031)2.24024552
155response to histamine (GO:0034776)2.23707757
156pyrimidine ribonucleotide biosynthetic process (GO:0009220)2.22575443
157cilium or flagellum-dependent cell motility (GO:0001539)14.6245027
158axonemal dynein complex assembly (GO:0070286)14.3601122
159cilium movement (GO:0003341)14.2580736
160epithelial cilium movement (GO:0003351)12.4627204
161epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)10.4490436
162axoneme assembly (GO:0035082)10.1002818

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.97379491
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.70137559
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.36772562
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.35791391
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.19615784
6CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.60666018
7FLI1_27457419_Chip-Seq_LIVER_Mouse2.39981879
8CTBP2_25329375_ChIP-Seq_LNCAP_Human2.33125983
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.31587194
10PCGF2_27294783_Chip-Seq_ESCs_Mouse2.27241288
11CBX2_27304074_Chip-Seq_ESCs_Mouse2.25521107
12GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.25129519
13GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.10467122
14PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.09513512
15GBX2_23144817_ChIP-Seq_PC3_Human2.08588050
16IGF1R_20145208_ChIP-Seq_DFB_Human2.07753796
17TAF15_26573619_Chip-Seq_HEK293_Human1.97390117
18EWS_26573619_Chip-Seq_HEK293_Human1.92597159
19PCGF2_27294783_Chip-Seq_NPCs_Mouse1.89493416
20SMAD4_21799915_ChIP-Seq_A2780_Human1.84517501
21TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.84468394
22SUZ12_27294783_Chip-Seq_NPCs_Mouse1.80379254
23* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.80130156
24RNF2_27304074_Chip-Seq_NSC_Mouse1.76976301
25FUS_26573619_Chip-Seq_HEK293_Human1.72350994
26RBPJ_22232070_ChIP-Seq_NCS_Mouse1.70699035
27EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.70091708
28P300_19829295_ChIP-Seq_ESCs_Human1.67980162
29CTBP1_25329375_ChIP-Seq_LNCAP_Human1.66336510
30NANOG_18555785_Chip-Seq_ESCs_Mouse1.64741664
31NFE2_27457419_Chip-Seq_LIVER_Mouse1.64140988
32JARID2_20064375_ChIP-Seq_MESCs_Mouse1.61931146
33GATA1_26923725_Chip-Seq_HPCs_Mouse1.61334665
34EED_16625203_ChIP-ChIP_MESCs_Mouse1.58413572
35VDR_22108803_ChIP-Seq_LS180_Human1.56624468
36REST_21632747_ChIP-Seq_MESCs_Mouse1.55068728
37KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.54387727
38AR_21572438_ChIP-Seq_LNCaP_Human1.53977610
39TAL1_26923725_Chip-Seq_HPCs_Mouse1.50801526
40CDX2_19796622_ChIP-Seq_MESCs_Mouse1.50771335
41NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.49966439
42BMI1_23680149_ChIP-Seq_NPCS_Mouse1.49832045
43RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.48655648
44P53_22387025_ChIP-Seq_ESCs_Mouse1.48423143
45TOP2B_26459242_ChIP-Seq_MCF-7_Human1.48357295
46ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.44877229
47TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.43145886
48MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.42942432
49AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.42725347
50SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.41898331
51TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.41738497
52JARID2_20075857_ChIP-Seq_MESCs_Mouse1.41652354
53SUZ12_18555785_Chip-Seq_ESCs_Mouse1.40832568
54SMAD3_21741376_ChIP-Seq_EPCs_Human1.40454463
55ZNF274_21170338_ChIP-Seq_K562_Hela1.40048150
56ER_23166858_ChIP-Seq_MCF-7_Human1.39605028
57CMYC_18555785_Chip-Seq_ESCs_Mouse1.39387466
58RNF2_27304074_Chip-Seq_ESCs_Mouse1.38695715
59DROSHA_22980978_ChIP-Seq_HELA_Human1.38322102
60MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.37722228
61OCT4_18555785_Chip-Seq_ESCs_Mouse1.37251465
62P300_18555785_Chip-Seq_ESCs_Mouse1.37063241
63EZH2_27294783_Chip-Seq_NPCs_Mouse1.36913407
64STAT3_18555785_Chip-Seq_ESCs_Mouse1.36671937
65STAT3_23295773_ChIP-Seq_U87_Human1.36608312
66BCAT_22108803_ChIP-Seq_LS180_Human1.36570323
67EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.35738651
68E2F1_18555785_Chip-Seq_ESCs_Mouse1.35209792
69TCF4_23295773_ChIP-Seq_U87_Human1.33234319
70RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.33210233
71SOX2_18555785_Chip-Seq_ESCs_Mouse1.32493753
72SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.30575116
73SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.30326744
74MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.29785521
75PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.29038778
76TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28807372
77POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.28807372
78* KDM2B_26808549_Chip-Seq_REH_Human1.28607085
79EZH2_27294783_Chip-Seq_ESCs_Mouse1.27543607
80* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.26678891
81SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.26664369
82RUNX2_22187159_ChIP-Seq_PCA_Human1.25909593
83EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.25434198
84* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.24982228
85KLF4_18555785_Chip-Seq_ESCs_Mouse1.23003646
86SALL1_21062744_ChIP-ChIP_HESCs_Human1.22820586
87EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.21130639
88NR3C1_21868756_ChIP-Seq_MCF10A_Human1.20905517
89* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.20807289
90RUNX1_27457419_Chip-Seq_LIVER_Mouse1.20112892
91SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.19906816
92POU5F1_16153702_ChIP-ChIP_HESCs_Human1.18485081
93CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.18405302
94* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.18290115
95ESRRB_18555785_Chip-Seq_ESCs_Mouse1.17610116
96ZFX_18555785_Chip-Seq_ESCs_Mouse1.17574728
97OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16932429
98KAP1_22055183_ChIP-Seq_ESCs_Mouse1.16503902
99* CRX_20693478_ChIP-Seq_RETINA_Mouse1.16124327
100CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15724305
101* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.15523459
102AR_25329375_ChIP-Seq_VCAP_Human1.15394397
103EZH2_18974828_ChIP-Seq_MESCs_Mouse1.14611300
104RNF2_18974828_ChIP-Seq_MESCs_Mouse1.14611300
105* FLI1_21867929_ChIP-Seq_TH2_Mouse1.14297942
106SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13948725
107TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.13906436
108REST_18959480_ChIP-ChIP_MESCs_Mouse1.13601648
109* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.13158421
110* CBP_20019798_ChIP-Seq_JUKART_Human1.12986742
111* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.12986742
112ARNT_22903824_ChIP-Seq_MCF-7_Human1.12483977
113PU1_27457419_Chip-Seq_LIVER_Mouse1.12436604
114LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11618514
115NMYC_18555785_Chip-Seq_ESCs_Mouse1.11447223
116PIAS1_25552417_ChIP-Seq_VCAP_Human1.10663271
117SUZ12_27294783_Chip-Seq_ESCs_Mouse1.10585428
118SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.10500372
119PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.10117002
120SMAD4_21741376_ChIP-Seq_EPCs_Human1.09416803
121CTCF_18555785_Chip-Seq_ESCs_Mouse1.09050933
122WDR5_24793694_ChIP-Seq_LNCAP_Human1.08880896
123ELK4_26923725_Chip-Seq_MESODERM_Mouse1.07127602
124TCF4_22108803_ChIP-Seq_LS180_Human1.07123779
125P53_22127205_ChIP-Seq_FIBROBLAST_Human1.06417435
126CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.06364609
127EZH2_27304074_Chip-Seq_ESCs_Mouse1.05547722
128SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.03789000
129GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.02849408
130NANOG_19829295_ChIP-Seq_ESCs_Human1.02405039
131SOX2_19829295_ChIP-Seq_ESCs_Human1.02405039
132KLF5_20875108_ChIP-Seq_MESCs_Mouse1.01997328
133STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.01798246
134IRF1_19129219_ChIP-ChIP_H3396_Human1.00413289
135CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.00344967
136TBL1_22424771_ChIP-Seq_293T_Human1.00260967
137* SOX2_21211035_ChIP-Seq_LN229_Gbm0.98373791
138RING1B_27294783_Chip-Seq_ESCs_Mouse0.97498540
139TP63_19390658_ChIP-ChIP_HaCaT_Human0.96473040

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization7.32714649
2MP0003136_yellow_coat_color5.98072944
3MP0002653_abnormal_ependyma_morphology4.47091758
4MP0008004_abnormal_stomach_pH3.51908709
5MP0003698_abnormal_male_reproductive3.39206002
6MP0001929_abnormal_gametogenesis3.02797803
7MP0005623_abnormal_meninges_morphology2.81782907
8MP0003880_abnormal_central_pattern2.76261735
9MP0001984_abnormal_olfaction2.65873651
10MP0009046_muscle_twitch2.43578260
11MP0010030_abnormal_orbit_morphology2.36268477
12MP0005646_abnormal_pituitary_gland2.36070083
13MP0008789_abnormal_olfactory_epithelium2.26031301
14MP0000566_synostosis2.18810394
15MP0001440_abnormal_grooming_behavior2.16427946
16MP0008877_abnormal_DNA_methylation2.12185931
17MP0009379_abnormal_foot_pigmentation2.09197286
18MP0002210_abnormal_sex_determination2.07987686
19MP0002822_catalepsy2.06422714
20MP0001529_abnormal_vocalization2.04960484
21MP0004859_abnormal_synaptic_plasticity2.01454680
22MP0003878_abnormal_ear_physiology1.97334637
23MP0005377_hearing/vestibular/ear_phenot1.97334637
24MP0003011_delayed_dark_adaptation1.96590923
25MP0002160_abnormal_reproductive_system1.95280358
26MP0006292_abnormal_olfactory_placode1.93107488
27MP0005499_abnormal_olfactory_system1.91234364
28MP0005394_taste/olfaction_phenotype1.91234364
29MP0002161_abnormal_fertility/fecundity1.81060850
30MP0002638_abnormal_pupillary_reflex1.80853686
31MP0003890_abnormal_embryonic-extraembry1.80826181
32MP0001293_anophthalmia1.72080369
33MP0004133_heterotaxia1.70560282
34MP0009745_abnormal_behavioral_response1.69514086
35MP0001145_abnormal_male_reproductive1.69025505
36MP0004270_analgesia1.68791401
37MP0003635_abnormal_synaptic_transmissio1.66252408
38MP0003787_abnormal_imprinting1.65915906
39MP0004885_abnormal_endolymph1.65705629
40MP0005551_abnormal_eye_electrophysiolog1.65334027
41MP0002928_abnormal_bile_duct1.63663092
42MP0000778_abnormal_nervous_system1.60860709
43MP0001501_abnormal_sleep_pattern1.60227074
44MP0000653_abnormal_sex_gland1.57059629
45MP0002736_abnormal_nociception_after1.56690479
46MP0001968_abnormal_touch/_nociception1.54046980
47MP0003122_maternal_imprinting1.53288748
48MP0002572_abnormal_emotion/affect_behav1.51865317
49MP0005248_abnormal_Harderian_gland1.51259537
50MP0008875_abnormal_xenobiotic_pharmacok1.47458842
51MP0004381_abnormal_hair_follicle1.47433175
52MP0002064_seizures1.46978534
53MP0002734_abnormal_mechanical_nocicepti1.46052057
54MP0000569_abnormal_digit_pigmentation1.41809639
55MP0002282_abnormal_trachea_morphology1.41109075
56MP0002063_abnormal_learning/memory/cond1.38886965
57MP0003950_abnormal_plasma_membrane1.38636374
58MP0001346_abnormal_lacrimal_gland1.34007775
59MP0002272_abnormal_nervous_system1.33782157
60MP0002735_abnormal_chemical_nociception1.32696482
61MP0001486_abnormal_startle_reflex1.32692532
62MP0001188_hyperpigmentation1.27897811
63MP0006276_abnormal_autonomic_nervous1.26661371
64MP0000383_abnormal_hair_follicle1.26203143
65MP0002557_abnormal_social/conspecific_i1.26039378
66MP0003121_genomic_imprinting1.24707866
67MP0005171_absent_coat_pigmentation1.20929848
68MP0002102_abnormal_ear_morphology1.19717429
69MP0001286_abnormal_eye_development1.15984431
70MP0005389_reproductive_system_phenotype1.14001467
71MP0004043_abnormal_pH_regulation1.12727526
72MP0003938_abnormal_ear_development1.11896626
73MP0005253_abnormal_eye_physiology1.07433976
74MP0000631_abnormal_neuroendocrine_gland1.06271204
75MP0002067_abnormal_sensory_capabilities1.05619489
76MP0004142_abnormal_muscle_tone1.03658631
77MP0002277_abnormal_respiratory_mucosa1.03606543
78MP0003942_abnormal_urinary_system1.02629118
79MP0005084_abnormal_gallbladder_morpholo1.02319499
80MP0001765_abnormal_ion_homeostasis0.99711774
81MP0003937_abnormal_limbs/digits/tail_de0.99140575
82MP0009780_abnormal_chondrocyte_physiolo0.98650564
83MP0005379_endocrine/exocrine_gland_phen0.97681791
84MP0003283_abnormal_digestive_organ0.97235071
85MP0001324_abnormal_eye_pigmentation0.97143093
86MP0003119_abnormal_digestive_system0.95806603
87MP0002249_abnormal_larynx_morphology0.94111380
88MP0004742_abnormal_vestibular_system0.93951604
89MP0002882_abnormal_neuron_morphology0.92325252
90MP0004145_abnormal_muscle_electrophysio0.91967609
91MP0002938_white_spotting0.91794627
92MP0003879_abnormal_hair_cell0.89264441
93MP0002752_abnormal_somatic_nervous0.89224949
94MP0004858_abnormal_nervous_system0.87559446
95MP0002184_abnormal_innervation0.87052752
96MP0005423_abnormal_somatic_nervous0.86947225
97MP0002152_abnormal_brain_morphology0.86540786
98MP0001502_abnormal_circadian_rhythm0.85915663
99MP0001905_abnormal_dopamine_level0.85125010
100MP0006072_abnormal_retinal_apoptosis0.83643599
101MP0002751_abnormal_autonomic_nervous0.82793620
102MP0003690_abnormal_glial_cell0.82652893
103MP0008995_early_reproductive_senescence0.81946705
104MP0005386_behavior/neurological_phenoty0.81730310
105MP0004924_abnormal_behavior0.81730310
106MP0000049_abnormal_middle_ear0.80930152
107MP0004019_abnormal_vitamin_homeostasis0.80865465
108MP0003634_abnormal_glial_cell0.80854094
109MP0005187_abnormal_penis_morphology0.80415790
110MP0002876_abnormal_thyroid_physiology0.79225622
111MP0000026_abnormal_inner_ear0.77555494
112MP0003329_amyloid_beta_deposits0.77287200
113MP0001963_abnormal_hearing_physiology0.76509114
114MP0003861_abnormal_nervous_system0.76108217
115MP0002234_abnormal_pharynx_morphology0.75940369
116MP0001485_abnormal_pinna_reflex0.75752799
117MP0005075_abnormal_melanosome_morpholog0.75020582
118MP0001970_abnormal_pain_threshold0.74877880
119MP0000955_abnormal_spinal_cord0.73348399
120MP0001958_emphysema0.72627344
121MP0003633_abnormal_nervous_system0.72018023
122MP0001177_atelectasis0.67521800
123MP0002229_neurodegeneration0.63881328
124MP0005409_darkened_coat_color0.63651633
125MP0005195_abnormal_posterior_eye0.63124055
126MP0005388_respiratory_system_phenotype0.63091943
127MP0002133_abnormal_respiratory_system0.63091943
128MP0003631_nervous_system_phenotype0.62226678
129MP0002066_abnormal_motor_capabilities/c0.60300297
130MP0005647_abnormal_sex_gland0.60178631
131MP0005391_vision/eye_phenotype0.59626178
132MP0005645_abnormal_hypothalamus_physiol0.59523081
133MP0002116_abnormal_craniofacial_bone0.58613195
134MP0004811_abnormal_neuron_physiology0.58448773
135MP0009250_abnormal_appendicular_skeleto0.58444980
136MP0002233_abnormal_nose_morphology0.56239800

Predicted human phenotypes

RankGene SetZ-score
1Absent/shortened dynein arms (HP:0200106)9.69462859
2Dynein arm defect of respiratory motile cilia (HP:0012255)9.69462859
3Rhinitis (HP:0012384)9.09854689
4Abnormal respiratory epithelium morphology (HP:0012253)8.90587347
5Abnormal respiratory motile cilium morphology (HP:0005938)8.90587347
6Chronic bronchitis (HP:0004469)7.39052926
7Bronchiectasis (HP:0002110)5.18551830
8Nasal polyposis (HP:0100582)5.04274047
9Pancreatic fibrosis (HP:0100732)4.22987764
10True hermaphroditism (HP:0010459)4.17026324
11Abnormality of the nasal mucosa (HP:0000433)4.02912067
12Infertility (HP:0000789)3.68838091
13Bronchitis (HP:0012387)3.64754544
14Nephronophthisis (HP:0000090)3.64305336
15Tubulointerstitial nephritis (HP:0001970)3.60729091
16Medial flaring of the eyebrow (HP:0010747)3.40200751
17Recurrent sinusitis (HP:0011108)3.38465003
18Chronic sinusitis (HP:0011109)3.09278007
19Abnormality of midbrain morphology (HP:0002418)3.08294139
20Molar tooth sign on MRI (HP:0002419)3.08294139
21Gait imbalance (HP:0002141)3.05425349
22Congenital primary aphakia (HP:0007707)3.01150023
23Pancreatic cysts (HP:0001737)2.99728783
24Median cleft lip (HP:0000161)2.97031854
25Chronic hepatic failure (HP:0100626)2.94760588
26Occipital encephalocele (HP:0002085)2.90216856
27Abnormality of the renal medulla (HP:0100957)2.86122380
28Postaxial foot polydactyly (HP:0001830)2.82520086
29Cystic liver disease (HP:0006706)2.74080879
30Supernumerary spleens (HP:0009799)2.70073701
31Nephrogenic diabetes insipidus (HP:0009806)2.64764195
32Congenital hepatic fibrosis (HP:0002612)2.64210802
33Aplasia/Hypoplasia of the tongue (HP:0010295)2.61494782
34Recurrent otitis media (HP:0000403)2.59794045
35Fibular hypoplasia (HP:0003038)2.57926593
36Genital tract atresia (HP:0001827)2.43574244
37Bile duct proliferation (HP:0001408)2.43148646
38Abnormal biliary tract physiology (HP:0012439)2.43148646
39Abnormality of permanent molar morphology (HP:0011071)2.40218680
40Abnormality of the dental root (HP:0006486)2.40218680
41Taurodontia (HP:0000679)2.40218680
42Vaginal atresia (HP:0000148)2.27557059
43Abnormality of molar (HP:0011077)2.25076051
44Abnormality of molar morphology (HP:0011070)2.25076051
45Poor coordination (HP:0002370)2.23352124
46Abnormality of the dental pulp (HP:0006479)2.18969817
47Tubulointerstitial abnormality (HP:0001969)2.15283359
48Anophthalmia (HP:0000528)2.11245005
49Postaxial hand polydactyly (HP:0001162)2.10506394
50Abnormality of dentin (HP:0010299)2.06663575
51Septo-optic dysplasia (HP:0100842)2.05149372
52Facial cleft (HP:0002006)2.03961002
53Tubular atrophy (HP:0000092)2.02581187
54Preaxial hand polydactyly (HP:0001177)2.01820085
55Anencephaly (HP:0002323)2.01095845
56Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.4789808
57Abnormal respiratory motile cilium physiology (HP:0012261)11.5293581
58Abnormal ciliary motility (HP:0012262)10.9018985
59Narrow forehead (HP:0000341)1.96753025
60Male pseudohermaphroditism (HP:0000037)1.96293297
61Asplenia (HP:0001746)1.86227885
62Aplasia/Hypoplasia of the spleen (HP:0010451)1.85258117
63Sclerocornea (HP:0000647)1.84758719
64Stage 5 chronic kidney disease (HP:0003774)1.81964475
65Tubulointerstitial fibrosis (HP:0005576)1.81589619
66Male infertility (HP:0003251)1.78061255
67Aplasia/Hypoplasia of the fibula (HP:0006492)1.77711430
68Aplasia/Hypoplasia of the lens (HP:0008063)1.73586296
69Aganglionic megacolon (HP:0002251)1.72532756
70Oculomotor apraxia (HP:0000657)1.70089906
71Prominent nasal bridge (HP:0000426)1.69647381
72Absent rod-and cone-mediated responses on ERG (HP:0007688)1.68539430
73Polyphagia (HP:0002591)1.66710370
74Myokymia (HP:0002411)1.65877108
75Abnormal rod and cone electroretinograms (HP:0008323)1.63925491
76Polyuria (HP:0000103)1.59583059
77Holoprosencephaly (HP:0001360)1.57492157
78Bony spicule pigmentary retinopathy (HP:0007737)1.57312487
79Abnormality of the renal cortex (HP:0011035)1.56990268
80Multicystic kidney dysplasia (HP:0000003)1.55584958
81Abnormality of the labia minora (HP:0012880)1.52953767
82Rib fusion (HP:0000902)1.50273706
83Chronic otitis media (HP:0000389)1.47618935
84Oligodactyly (hands) (HP:0001180)1.47498179
85Abnormal drinking behavior (HP:0030082)1.47388820
86Polydipsia (HP:0001959)1.47388820
87Short foot (HP:0001773)1.46862839
88Furrowed tongue (HP:0000221)1.46197070
89Decreased testicular size (HP:0008734)1.46047420
90Focal motor seizures (HP:0011153)1.45443314
91Maternal diabetes (HP:0009800)1.45429630
92Highly arched eyebrow (HP:0002553)1.44464661
93Left ventricular hypertrophy (HP:0001712)1.44437329
94Hyperglycinemia (HP:0002154)1.42250190
95Bifid tongue (HP:0010297)1.42214393
96Hypodontia (HP:0000668)1.42098224
97Optic nerve hypoplasia (HP:0000609)1.40494535
98Cutaneous finger syndactyly (HP:0010554)1.39567158
99Type II lissencephaly (HP:0007260)1.39240288
100Acute necrotizing encephalopathy (HP:0006965)1.38400857
101Dandy-Walker malformation (HP:0001305)1.38034073
102Atelectasis (HP:0100750)1.37892834
103Abolished electroretinogram (ERG) (HP:0000550)1.36633731
104Abnormality of renal excretion (HP:0011036)1.35161777
105Sex reversal (HP:0012245)1.34413232
106Abnormal sex determination (HP:0012244)1.34413232
107Broad foot (HP:0001769)1.33905892
108Specific learning disability (HP:0001328)1.32179886
109Nephropathy (HP:0000112)1.31373120
110Aplasia involving bones of the extremities (HP:0009825)1.29513944
111Aplasia involving bones of the upper limbs (HP:0009823)1.29513944
112Aplasia of the phalanges of the hand (HP:0009802)1.29513944
113Microglossia (HP:0000171)1.26616343
114Abnormality of renal resorption (HP:0011038)1.25612794
115Short ribs (HP:0000773)1.24830134
116Broad distal phalanx of finger (HP:0009836)1.24671324
117Retinitis pigmentosa (HP:0000510)1.23998715
118Decreased central vision (HP:0007663)1.22387296
119Renal dysplasia (HP:0000110)1.21270125
120Progressive cerebellar ataxia (HP:0002073)1.20892238
121Dental crowding (HP:0000678)1.20146182
122Polycystic kidney dysplasia (HP:0000113)1.19464972
123Abnormality of abdominal situs (HP:0011620)1.19020279
124Abdominal situs inversus (HP:0003363)1.19020279
125Bell-shaped thorax (HP:0001591)1.16046298
126Recurrent bronchitis (HP:0002837)1.15222289
12711 pairs of ribs (HP:0000878)1.14151242
128Abnormality of macular pigmentation (HP:0008002)1.13951023
129Neonatal short-limb short stature (HP:0008921)1.13509953
130Ectopic anus (HP:0004397)1.12826749
131Cone-rod dystrophy (HP:0000548)1.12599996
132Short thorax (HP:0010306)1.12248116
133Polycystic ovaries (HP:0000147)1.11412659

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PNCK6.37243331
2PDK35.95098615
3PDK45.95098615
4MAPK154.72117599
5PDK23.83859186
6STK163.63723704
7STK392.48625471
8WNK42.06232132
9CASK1.88359200
10MAP4K21.84699368
11PTK2B1.78723296
12MST41.73394252
13DYRK21.72442365
14GRK11.63857386
15MAP2K71.55870552
16EPHA41.51685775
17BMPR1B1.42593983
18EPHB21.42247030
19PLK21.39672861
20TLK11.37533918
21TNIK1.33926586
22INSRR1.31308529
23MAP3K41.30868703
24BRSK21.29291027
25NTRK31.27039032
26NTRK21.18041739
27IRAK11.15397819
28PRKCG1.13430724
29LMTK21.05343087
30NEK61.03971098
31DYRK1B1.03170546
32LATS11.00589955
33DAPK20.99321040
34WNK10.97370080
35ERBB30.95646962
36TESK10.90544752
37WEE10.88398763
38STK38L0.88111578
39TSSK60.86147384
40GRK50.86125445
41CDK30.85704082
42MUSK0.83262773
43CAMKK20.82019456
44MAPK130.81879184
45NME10.80831691
46BMPR20.80801795
47PRKD30.73535571
48MARK10.73207789
49ZAK0.72961938
50UHMK10.70986989
51DYRK1A0.70165103
52ERBB20.69860736
53TRIM280.67622532
54MINK10.66083634
55CAMK2A0.65897857
56ACVR1B0.64383351
57MAP2K40.64324975
58CAMK1G0.64112072
59PHKG20.64092435
60PHKG10.64092435
61MAP2K20.63291379
62ADRBK20.63171960
63OXSR10.63084252
64TIE10.61283396
65VRK10.61078207
66ADRBK10.61020438
67CDK190.60560037
68BCKDK0.60046740
69SGK20.58851290
70ICK0.58250108
71EPHA30.58115173
72CAMKK10.57596190
73SGK2230.55933210
74SGK4940.55933210
75PLK40.55443393
76RIPK40.54706012
77STK30.53796060
78DMPK0.53595139
79STK380.53405871
80FGR0.53282235
81BCR0.53277082
82TAF10.52401432
83TAOK30.52148918
84CAMK2B0.52125247
85PRKCE0.51658201
86GRK70.51272561
87PDK10.50968837
88MAP3K20.50967668
89AURKA0.50407071
90DYRK30.50228772
91MAPKAPK50.50074125
92FGFR20.49503170
93AKT30.49040073
94CHEK20.47366025
95PLK10.47150016
96PRKG10.46043660
97NUAK10.45894929
98NLK0.45452084
99PRKCZ0.44763732
100MARK20.43233053
101PLK30.43185018
102CDK50.42652786
103PINK10.41474254
104CAMK10.40703771
105MAP3K60.39740827
106MKNK10.39102785
107LATS20.38918212
108PRKCQ0.37899760
109SIK20.37115051
110RPS6KA20.36613259
111ROCK20.35950081
112TGFBR10.35526320
113ROCK10.35523481
114PKN10.35522677
115CSNK1G10.34792988
116MAP3K120.34540817
117PRKACA0.34392071
118CDC70.32932882
119MKNK20.32650000
120CSNK1A1L0.32641145
121CSNK1A10.32218594
122WNK30.32218057
123TTK0.31929249
124BRSK10.31804594
125CSNK1E0.31697451
126PASK0.30952943
127TYRO30.30640647
128FER0.30490540
129CCNB10.30015783
130CSNK1G30.29251039
131STK110.28211184
132PAK30.27701948
133CAMK2D0.27700588
134MAPK70.26620130
135PRKACB0.25260981
136FRK0.24975068
137PRKCA0.23626379
138STK100.23439735
139SGK10.23264620
140CSNK1G20.23013216
141MAPK120.22952109

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.04088981
2Huntingtons disease_Homo sapiens_hsa050162.94230337
3Amphetamine addiction_Homo sapiens_hsa050312.62936593
4Vitamin B6 metabolism_Homo sapiens_hsa007502.58563386
5Olfactory transduction_Homo sapiens_hsa047402.42545844
6Pyruvate metabolism_Homo sapiens_hsa006202.25846148
7Basal cell carcinoma_Homo sapiens_hsa052172.16226309
8Steroid biosynthesis_Homo sapiens_hsa001002.14976299
9Circadian entrainment_Homo sapiens_hsa047132.10042881
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.04991598
11Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.02204101
12Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.00687306
13Glutamatergic synapse_Homo sapiens_hsa047241.96474738
14Gastric acid secretion_Homo sapiens_hsa049711.93485519
15Taste transduction_Homo sapiens_hsa047421.93176003
16Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.92651737
17Dorso-ventral axis formation_Homo sapiens_hsa043201.91701499
18Protein export_Homo sapiens_hsa030601.90799062
19Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.80023208
20Synaptic vesicle cycle_Homo sapiens_hsa047211.67429521
21Ribosome_Homo sapiens_hsa030101.67068110
22Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.65463333
23Insulin secretion_Homo sapiens_hsa049111.65254543
24Renin secretion_Homo sapiens_hsa049241.62922251
25Salivary secretion_Homo sapiens_hsa049701.60184032
26Collecting duct acid secretion_Homo sapiens_hsa049661.59539464
27Long-term potentiation_Homo sapiens_hsa047201.57690261
28Calcium signaling pathway_Homo sapiens_hsa040201.57170644
29Morphine addiction_Homo sapiens_hsa050321.54606660
30Cocaine addiction_Homo sapiens_hsa050301.52794245
31GABAergic synapse_Homo sapiens_hsa047271.52404705
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.50745314
33Glucagon signaling pathway_Homo sapiens_hsa049221.50530047
34Phototransduction_Homo sapiens_hsa047441.47135358
35Dopaminergic synapse_Homo sapiens_hsa047281.46873217
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.46459836
37Mineral absorption_Homo sapiens_hsa049781.46073990
38Propanoate metabolism_Homo sapiens_hsa006401.45171549
39Cardiac muscle contraction_Homo sapiens_hsa042601.37130944
40Caffeine metabolism_Homo sapiens_hsa002321.35840395
41Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.35047311
42Nitrogen metabolism_Homo sapiens_hsa009101.34667189
43Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.33691689
44Ether lipid metabolism_Homo sapiens_hsa005651.32990815
45Serotonergic synapse_Homo sapiens_hsa047261.31154294
46Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.29309464
47Circadian rhythm_Homo sapiens_hsa047101.28183862
48Primary bile acid biosynthesis_Homo sapiens_hsa001201.27344496
49Oxidative phosphorylation_Homo sapiens_hsa001901.26106385
50Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.23306580
51Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.22243617
52beta-Alanine metabolism_Homo sapiens_hsa004101.20727672
53Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.19229071
54Hippo signaling pathway_Homo sapiens_hsa043901.16041879
55cAMP signaling pathway_Homo sapiens_hsa040241.15603978
56Fatty acid biosynthesis_Homo sapiens_hsa000611.11428592
57Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.10654350
58Basal transcription factors_Homo sapiens_hsa030221.07381527
59Histidine metabolism_Homo sapiens_hsa003401.06289451
60Oocyte meiosis_Homo sapiens_hsa041141.05961466
61Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.05729220
62Steroid hormone biosynthesis_Homo sapiens_hsa001401.04341598
63Aldosterone synthesis and secretion_Homo sapiens_hsa049251.01895817
64Phenylalanine metabolism_Homo sapiens_hsa003601.00594592
65Alzheimers disease_Homo sapiens_hsa050101.00510173
66Peroxisome_Homo sapiens_hsa041461.00454099
67Thyroid hormone synthesis_Homo sapiens_hsa049180.99968205
68Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.99479702
69Maturity onset diabetes of the young_Homo sapiens_hsa049500.99216464
70Retinol metabolism_Homo sapiens_hsa008300.98227772
71Sphingolipid metabolism_Homo sapiens_hsa006000.97806615
72Homologous recombination_Homo sapiens_hsa034400.95787483
73Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.92905659
74Estrogen signaling pathway_Homo sapiens_hsa049150.91606061
75Regulation of autophagy_Homo sapiens_hsa041400.90072700
76Glycerolipid metabolism_Homo sapiens_hsa005610.89983327
77Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.89304491
78Tyrosine metabolism_Homo sapiens_hsa003500.88228939
79Tryptophan metabolism_Homo sapiens_hsa003800.87493284
80Phosphatidylinositol signaling system_Homo sapiens_hsa040700.85727945
81cGMP-PKG signaling pathway_Homo sapiens_hsa040220.84040408
82Sulfur metabolism_Homo sapiens_hsa009200.83870356
83Linoleic acid metabolism_Homo sapiens_hsa005910.81056265
84Hedgehog signaling pathway_Homo sapiens_hsa043400.80727858
85Oxytocin signaling pathway_Homo sapiens_hsa049210.80359044
86RNA polymerase_Homo sapiens_hsa030200.79126970
87Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.76894848
88Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.76883551
89Wnt signaling pathway_Homo sapiens_hsa043100.76741585
90Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.76308113
91Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.75228756
92Vibrio cholerae infection_Homo sapiens_hsa051100.73774200
93Glycosaminoglycan degradation_Homo sapiens_hsa005310.73726027
94Axon guidance_Homo sapiens_hsa043600.73085957
95Parkinsons disease_Homo sapiens_hsa050120.72121962
96Glycerophospholipid metabolism_Homo sapiens_hsa005640.71977267
97Purine metabolism_Homo sapiens_hsa002300.69886508
98Ovarian steroidogenesis_Homo sapiens_hsa049130.69551665
99Inositol phosphate metabolism_Homo sapiens_hsa005620.69020454
100Cholinergic synapse_Homo sapiens_hsa047250.68751055
101PPAR signaling pathway_Homo sapiens_hsa033200.68118004
102Fanconi anemia pathway_Homo sapiens_hsa034600.67250434
103Pancreatic secretion_Homo sapiens_hsa049720.67124101
104alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.67115223
105TGF-beta signaling pathway_Homo sapiens_hsa043500.65408622
106Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.63588036
107Gap junction_Homo sapiens_hsa045400.62954345
108Vascular smooth muscle contraction_Homo sapiens_hsa042700.61788472
109Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.61109231
110ABC transporters_Homo sapiens_hsa020100.59829502
111Long-term depression_Homo sapiens_hsa047300.58505679
112Melanogenesis_Homo sapiens_hsa049160.58208840
113Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.58058367
114Bile secretion_Homo sapiens_hsa049760.58011406
115Nucleotide excision repair_Homo sapiens_hsa034200.55956926
116Fatty acid degradation_Homo sapiens_hsa000710.55540892
117RNA degradation_Homo sapiens_hsa030180.54119584
118Notch signaling pathway_Homo sapiens_hsa043300.53725357
119Arachidonic acid metabolism_Homo sapiens_hsa005900.52353134
120GnRH signaling pathway_Homo sapiens_hsa049120.50883438
121Pentose and glucuronate interconversions_Homo sapiens_hsa000400.50587186
122Glutathione metabolism_Homo sapiens_hsa004800.49917222
123Carbohydrate digestion and absorption_Homo sapiens_hsa049730.46838809
124Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.46698678
125Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.45538853
126Vitamin digestion and absorption_Homo sapiens_hsa049770.45149487
127Folate biosynthesis_Homo sapiens_hsa007900.43259155
128Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.41987632
129Alcoholism_Homo sapiens_hsa050340.38688278
130Tight junction_Homo sapiens_hsa045300.38084272
131Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.37891530
132Fatty acid elongation_Homo sapiens_hsa000620.37610110
133Rheumatoid arthritis_Homo sapiens_hsa053230.37401015
134Metabolic pathways_Homo sapiens_hsa011000.36411902
135Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.35851687
136Chemical carcinogenesis_Homo sapiens_hsa052040.35434960
137Mismatch repair_Homo sapiens_hsa034300.35149180
138Butanoate metabolism_Homo sapiens_hsa006500.34638479
139Protein digestion and absorption_Homo sapiens_hsa049740.33784555

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