LRRIQ4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm motility (GO:0030317)9.62686138
2sperm-egg recognition (GO:0035036)9.37014852
3multicellular organism reproduction (GO:0032504)8.82851359
4acrosome assembly (GO:0001675)8.79940085
5binding of sperm to zona pellucida (GO:0007339)8.76743182
6response to pheromone (GO:0019236)8.59873186
7cell-cell recognition (GO:0009988)8.35392935
8cilium or flagellum-dependent cell motility (GO:0001539)8.34291357
9plasma membrane fusion (GO:0045026)8.31453521
10piRNA metabolic process (GO:0034587)8.12498927
11epithelial cilium movement (GO:0003351)7.96450363
12acrosome reaction (GO:0007340)7.91416136
13axonemal dynein complex assembly (GO:0070286)7.85309554
14motile cilium assembly (GO:0044458)7.60699031
15spermatid development (GO:0007286)7.50139102
16protein targeting to Golgi (GO:0000042)7.37563455
17reproduction (GO:0000003)7.37449216
18establishment of protein localization to Golgi (GO:0072600)7.14872805
19synaptonemal complex assembly (GO:0007130)6.96756932
20retrograde transport, vesicle recycling within Golgi (GO:0000301)6.90451912
21male meiosis (GO:0007140)6.89378338
22synaptonemal complex organization (GO:0070193)6.85513412
23cilium movement (GO:0003341)6.52941822
24regulation of cilium movement (GO:0003352)6.38487396
25epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.36539079
26microtubule depolymerization (GO:0007019)5.88305039
27single fertilization (GO:0007338)5.87411334
28rRNA methylation (GO:0031167)5.84572881
29DNA methylation involved in gamete generation (GO:0043046)5.69199955
30sexual reproduction (GO:0019953)5.69149447
31protein localization to Golgi apparatus (GO:0034067)5.59183338
32estrogen biosynthetic process (GO:0006703)5.26963418
33spermatogenesis (GO:0007283)5.19160305
34male gamete generation (GO:0048232)5.18157678
35fertilization (GO:0009566)5.17482229
36chromosome organization involved in meiosis (GO:0070192)5.13171392
37sperm capacitation (GO:0048240)5.07354919
38meiotic nuclear division (GO:0007126)4.83536764
39rRNA modification (GO:0000154)4.83480344
40gamete generation (GO:0007276)4.81599534
41germ cell development (GO:0007281)4.64908664
42phosphatidylethanolamine biosynthetic process (GO:0006646)4.62666654
43chromatin silencing (GO:0006342)4.55751228
44male meiosis I (GO:0007141)4.49534976
45chaperone-mediated protein complex assembly (GO:0051131)4.46899612
46cellular process involved in reproduction in multicellular organism (GO:0022412)4.44103169
47positive regulation of Rab GTPase activity (GO:0032851)4.43871399
48regulation of Rab GTPase activity (GO:0032313)4.43871399
49phosphatidylethanolamine metabolic process (GO:0046337)4.33684336
50negative regulation of inclusion body assembly (GO:0090084)4.29958107
51axoneme assembly (GO:0035082)4.19381280
52regulation of vesicle fusion (GO:0031338)4.12835852
53organic cation transport (GO:0015695)4.06701912
54chromosome condensation (GO:0030261)4.01685400
55cellular ketone body metabolic process (GO:0046950)4.00733750
56antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.99518196
57single strand break repair (GO:0000012)3.95202339
58nuclear pore complex assembly (GO:0051292)3.93859798
59regulation of inclusion body assembly (GO:0090083)3.93271817
60ventricular system development (GO:0021591)3.92602582
61DNA packaging (GO:0006323)3.90036250
62glomerular visceral epithelial cell development (GO:0072015)3.84586279
63regulation of microtubule-based movement (GO:0060632)3.82778539
64meiosis I (GO:0007127)3.82039004
65cell recognition (GO:0008037)3.81080914
66regulation of centriole replication (GO:0046599)3.79874631
67spermatid nucleus differentiation (GO:0007289)3.75050467
68multicellular organismal reproductive process (GO:0048609)3.74904201
69histone H3-K9 demethylation (GO:0033169)3.74719644
70microtubule nucleation (GO:0007020)3.72987596
71microtubule severing (GO:0051013)3.72867161
72glomerular epithelial cell development (GO:0072310)3.71448606
73nuclear pore organization (GO:0006999)3.70645331
74DNA replication-dependent nucleosome organization (GO:0034723)3.69655057
75DNA replication-dependent nucleosome assembly (GO:0006335)3.69655057
76meiotic cell cycle (GO:0051321)3.68872531
77negative regulation of T cell differentiation in thymus (GO:0033085)3.62659562
78gene silencing by RNA (GO:0031047)3.56089847
79monoubiquitinated protein deubiquitination (GO:0035520)3.55382527
80calcium ion-dependent exocytosis (GO:0017156)3.53408706
81meiotic cell cycle process (GO:1903046)3.52859633
82ketone body metabolic process (GO:1902224)3.50840445
83negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.47383268
84regulation of transcription involved in cell fate commitment (GO:0060850)3.47298969
85nucleosome disassembly (GO:0006337)3.45476993
86protein-DNA complex disassembly (GO:0032986)3.45476993
87regulation of meiosis I (GO:0060631)3.42695738
88histone exchange (GO:0043486)3.38702847
89glycerol ether metabolic process (GO:0006662)3.38090182
90regulation of spindle checkpoint (GO:0090231)3.37067000
91microtubule polymerization or depolymerization (GO:0031109)3.31651009
92peptidyl-glutamic acid modification (GO:0018200)3.30772955
93mitotic sister chromatid cohesion (GO:0007064)3.30165967
94seminiferous tubule development (GO:0072520)3.28713449
95cellular response to pH (GO:0071467)3.25183767
96histone H3-K36 demethylation (GO:0070544)3.22587386
97negative regulation of gene expression, epigenetic (GO:0045814)3.18611611
98sequestering of actin monomers (GO:0042989)3.17912079
99histone mRNA catabolic process (GO:0071044)3.17782160
100regulation of cilium assembly (GO:1902017)3.17639299
101RNA destabilization (GO:0050779)3.16927088
102nonmotile primary cilium assembly (GO:0035058)3.16408229
103protein localization to chromosome, centromeric region (GO:0071459)3.15229026
104nucleus organization (GO:0006997)3.12727932
105ether metabolic process (GO:0018904)3.11075053
106homeostasis of number of cells within a tissue (GO:0048873)3.10988823
107negative regulation of organelle assembly (GO:1902116)3.10468559
108synapsis (GO:0007129)3.09870001
109protein K6-linked ubiquitination (GO:0085020)3.09021741
110cilium assembly (GO:0042384)3.08078967
111pentose metabolic process (GO:0019321)3.07126740
112intra-Golgi vesicle-mediated transport (GO:0006891)3.04854813
113cilium organization (GO:0044782)3.03893255
114multicellular organismal movement (GO:0050879)3.03596420
115musculoskeletal movement (GO:0050881)3.03596420
116centriole assembly (GO:0098534)3.03087413
117centriole replication (GO:0007099)3.02120463
118pore complex assembly (GO:0046931)3.01075595
119cranial nerve morphogenesis (GO:0021602)2.95376604
120multicellular organismal development (GO:0007275)2.92597741
121sister chromatid cohesion (GO:0007062)2.91944112
122detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.90360854
123protein K11-linked deubiquitination (GO:0035871)2.90104812
124gene silencing (GO:0016458)2.88817895
125regulation of histone H3-K9 methylation (GO:0051570)2.87487113
126mesonephros development (GO:0001823)2.85741745
127mitotic nuclear envelope disassembly (GO:0007077)2.83467047
128protein polyglutamylation (GO:0018095)2.83073661
129left/right pattern formation (GO:0060972)2.81440025
130regulation of centrosome cycle (GO:0046605)2.80939859
131heterochromatin organization (GO:0070828)2.78987106
132reciprocal meiotic recombination (GO:0007131)2.78872282
133reciprocal DNA recombination (GO:0035825)2.78872282
134GTP biosynthetic process (GO:0006183)2.75345180
135DNA alkylation (GO:0006305)2.74688868
136DNA methylation (GO:0006306)2.74688868
137protein localization to cilium (GO:0061512)2.74525059
138nucleoside diphosphate phosphorylation (GO:0006165)2.74153804
139UTP biosynthetic process (GO:0006228)2.71451381
140regulation of chromosome segregation (GO:0051983)2.71191623
141meiotic chromosome segregation (GO:0045132)2.71116357
142protein refolding (GO:0042026)2.70603943
143chromosome organization (GO:0051276)2.68857544
144fusion of sperm to egg plasma membrane (GO:0007342)11.0202665
145cell wall macromolecule catabolic process (GO:0016998)10.5545550
146cell wall macromolecule metabolic process (GO:0044036)10.5545550

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.79510749
2E2F7_22180533_ChIP-Seq_HELA_Human4.90660005
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.79160551
4FOXM1_23109430_ChIP-Seq_U2OS_Human2.93193734
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.86477664
6MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.85937604
7BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.40571527
8CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.37736125
9CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.34586526
10VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.33706150
11CTBP1_25329375_ChIP-Seq_LNCAP_Human2.31785123
12MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.24240276
13SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.19494476
14E2F4_17652178_ChIP-ChIP_JURKAT_Human2.16989080
15PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.14058748
16FUS_26573619_Chip-Seq_HEK293_Human2.13408697
17CTBP2_25329375_ChIP-Seq_LNCAP_Human2.13052975
18CBP_20019798_ChIP-Seq_JUKART_Human2.07804105
19IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.07804105
20ELF1_20517297_ChIP-Seq_JURKAT_Human2.06100588
21ERA_21632823_ChIP-Seq_H3396_Human2.05942530
22FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.01513150
23* ER_23166858_ChIP-Seq_MCF-7_Human1.98205769
24MYC_18555785_ChIP-Seq_MESCs_Mouse1.97233541
25NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.96657851
26EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.95030270
27RAC3_21632823_ChIP-Seq_H3396_Human1.91563164
28TP63_19390658_ChIP-ChIP_HaCaT_Human1.91118643
29FLI1_27457419_Chip-Seq_LIVER_Mouse1.88645125
30POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.88250297
31TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.88250297
32SMC4_20622854_ChIP-Seq_HELA_Human1.87496463
33KAP1_22055183_ChIP-Seq_ESCs_Mouse1.87437566
34EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.86861893
35EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.83764359
36BCL6_27268052_Chip-Seq_Bcells_Human1.81906560
37DROSHA_22980978_ChIP-Seq_HELA_Human1.80820882
38GATA1_26923725_Chip-Seq_HPCs_Mouse1.80120444
39RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.79230629
40EZH2_22144423_ChIP-Seq_EOC_Human1.79175841
41SALL1_21062744_ChIP-ChIP_HESCs_Human1.76939837
42NANOG_20526341_ChIP-Seq_ESCs_Human1.72227077
43MYC_19079543_ChIP-ChIP_MESCs_Mouse1.70634410
44GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.69392274
45GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.67207677
46STAT6_21828071_ChIP-Seq_BEAS2B_Human1.66534092
47BCOR_27268052_Chip-Seq_Bcells_Human1.65245011
48TAF2_19829295_ChIP-Seq_ESCs_Human1.64835737
49ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.64494757
50P300_27268052_Chip-Seq_Bcells_Human1.63786407
51ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.58796049
52MYC_19829295_ChIP-Seq_ESCs_Human1.58156678
53CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.55966842
54E2F1_20622854_ChIP-Seq_HELA_Human1.54884733
55GATA3_21878914_ChIP-Seq_MCF-7_Human1.54351407
56MYC_18358816_ChIP-ChIP_MESCs_Mouse1.53934506
57P68_20966046_ChIP-Seq_HELA_Human1.52706983
58PHF8_20622854_ChIP-Seq_HELA_Human1.50370043
59HNFA_21074721_ChIP-Seq_CACO-2_Human1.49763484
60STAT3_1855785_ChIP-Seq_MESCs_Mouse1.49620443
61MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.49385196
62CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.49114136
63ARNT_22903824_ChIP-Seq_MCF-7_Human1.48638745
64UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.48621193
65CEBPB_22108803_ChIP-Seq_LS180_Human1.48345372
66CBX2_22325352_ChIP-Seq_293T-Rex_Human1.48288350
67MYC_19030024_ChIP-ChIP_MESCs_Mouse1.48026645
68CTCF_27219007_Chip-Seq_Bcells_Human1.47797923
69TP63_22573176_ChIP-Seq_HFKS_Human1.47757732
70MYCN_18555785_ChIP-Seq_MESCs_Mouse1.47149027
71VDR_22108803_ChIP-Seq_LS180_Human1.43929172
72TDRD3_21172665_ChIP-Seq_MCF-7_Human1.43490332
73ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.43324400
74PCGF2_27294783_Chip-Seq_ESCs_Mouse1.43089086
75FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.40858078
76PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.40377084
77KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.39753261
78ETV1_20927104_ChIP-Seq_GIST48_Human1.38850073
79SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.38845183
80RBPJ_21746931_ChIP-Seq_IB4_Human1.37567918
81SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.36307074
82POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.35500072
83NANOG_18555785_ChIP-Seq_MESCs_Mouse1.35270131
84RBPJ_22232070_ChIP-Seq_NCS_Mouse1.34721886
85KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.34522104
86SMAD3_21741376_ChIP-Seq_ESCs_Human1.33420676
87SOX2_18555785_ChIP-Seq_MESCs_Mouse1.32276724
88TP53_18474530_ChIP-ChIP_U2OS_Human1.32156416
89NFYB_21822215_ChIP-Seq_K562_Human1.31238808
90SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.30525472
91CTCF_20526341_ChIP-Seq_ESCs_Human1.30222907
92SMAD3_21741376_ChIP-Seq_EPCs_Human1.28698335
93AR_25329375_ChIP-Seq_VCAP_Human1.28198513
94TBL1_22424771_ChIP-Seq_293T_Human1.27197108
95GATA6_21074721_ChIP-Seq_CACO-2_Human1.24972436
96FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24391620
97SOX2_22085726_ChIP-Seq_NPCs_Mouse1.24070482
98PHF8_20622853_ChIP-Seq_HELA_Human1.23613721
99TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.23393015
100* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.23232575
101P300_19829295_ChIP-Seq_ESCs_Human1.23078183
102AR_21909140_ChIP-Seq_LNCAP_Human1.22861047
103GATA3_21867929_ChIP-Seq_CD8_Mouse1.22618853
104ERG_20517297_ChIP-Seq_VCAP_Human1.22530885
105SMAD4_21741376_ChIP-Seq_EPCs_Human1.20649933
106ETV2_25802403_ChIP-Seq_MESCs_Mouse1.20408128
107ELK4_26923725_Chip-Seq_MESODERM_Mouse1.19113673
108POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.19020114
109RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.17671662
110OCT4_20526341_ChIP-Seq_ESCs_Human1.17662340
111EST1_17652178_ChIP-ChIP_JURKAT_Human1.16544376
112GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.16167179
113* STAT1_17558387_ChIP-Seq_HELA_Human1.15714067
114KLF5_20875108_ChIP-Seq_MESCs_Mouse1.15702756
115SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.15474699
116JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.14633429
117GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.14147707
118TAF15_26573619_Chip-Seq_HEK293_Human1.13969468
119PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.13090293
120TOP2B_26459242_ChIP-Seq_MCF-7_Human1.12720248
121RUNX2_22187159_ChIP-Seq_PCA_Human1.12652836
122GATA3_21867929_ChIP-Seq_TH1_Mouse1.10638147
123TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.10404465
124RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.10119338
125CTCF_21964334_Chip-Seq_Bcells_Human1.09560747
126PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.09509306
127RUNX1_27514584_Chip-Seq_MCF-7_Human1.08975195
128YY1_22570637_ChIP-Seq_MALME-3M_Human1.08011600
129P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.07550616
130OCT4_19829295_ChIP-Seq_ESCs_Human1.06527770
131YY1_21170310_ChIP-Seq_MESCs_Mouse1.06523254
132P53_22127205_ChIP-Seq_FIBROBLAST_Human1.06493718
133NFYA_21822215_ChIP-Seq_K562_Human1.06308610
134AUTS2_25519132_ChIP-Seq_293T-REX_Human1.05504665
135LXR_22292898_ChIP-Seq_THP-1_Human1.05282589
136SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.05057480
137CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.04898696
138STAT3_23295773_ChIP-Seq_U87_Human1.04850443
139BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human1.04703253
140PKCTHETA_26484144_Chip-Seq_BREAST_Human1.04359384
141EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.03439806
142AR_21572438_ChIP-Seq_LNCaP_Human1.01791869
143LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.01551262
144CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.01241234
145OCT1_27270436_Chip-Seq_PROSTATE_Human1.01097274
146WDR5_24793694_ChIP-Seq_LNCAP_Human1.00868837
147KLF4_19829295_ChIP-Seq_ESCs_Human1.00460179
148STAT1_20625510_ChIP-Seq_HELA_Human1.00330496
149PCGF2_27294783_Chip-Seq_NPCs_Mouse0.96930698
150CREB1_15753290_ChIP-ChIP_HEK293T_Human0.95868271
151ETS1_20019798_ChIP-Seq_JURKAT_Human0.95200402
152POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.94832333
153FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.94645019
154ZNF274_21170338_ChIP-Seq_K562_Hela0.94374092
155XRN2_22483619_ChIP-Seq_HELA_Human0.93011067
156NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.91655447
157TAL1_26923725_Chip-Seq_HPCs_Mouse0.90044248
158NFE2_27457419_Chip-Seq_LIVER_Mouse0.89846549
159NANOG_18692474_ChIP-Seq_MEFs_Mouse0.88940928
160NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.88625134
161STAT3_18555785_ChIP-Seq_MESCs_Mouse0.88560548
162RARA_24833708_ChIP-Seq_LIVER_Mouse0.88065252
163NELFA_20434984_ChIP-Seq_ESCs_Mouse0.87262138
164NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.86770527
165ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.86431895
166SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.85213264
167RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.84844596
168KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.84766060
169SPI1_26923725_Chip-Seq_HPCs_Mouse0.84650802
170E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.84229833
171TCF3_18692474_ChIP-Seq_MESCs_Mouse0.84209345
172KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.83864011
173NANOG_18692474_ChIP-Seq_MESCs_Mouse0.83787667
174KLF4_18555785_ChIP-Seq_MESCs_Mouse0.83712874
175MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.83483862
176KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.83055232
177KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.83055232
178KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.83055232
179POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.82648289
180RUNX1_26923725_Chip-Seq_HPCs_Mouse0.82551238
181VDR_23849224_ChIP-Seq_CD4+_Human0.81595286
182P53_21459846_ChIP-Seq_SAOS-2_Human0.81196187
183ESET_19884257_ChIP-Seq_ESCs_Mouse0.80339101
184RXRA_24833708_ChIP-Seq_LIVER_Mouse0.80238490
185SOX2_18692474_ChIP-Seq_MESCs_Mouse0.79815306
186NANOG_21062744_ChIP-ChIP_HESCs_Human0.79752284
187SUZ12_27294783_Chip-Seq_NPCs_Mouse0.79748010

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation5.25664752
2MP0003698_abnormal_male_reproductive5.12559040
3MP0001929_abnormal_gametogenesis5.06700829
4MP0002210_abnormal_sex_determination3.82434001
5MP0002653_abnormal_ependyma_morphology3.52933158
6MP0010094_abnormal_chromosome_stability3.27308504
7MP0001145_abnormal_male_reproductive3.23286572
8MP0001348_abnormal_lacrimal_gland3.00871780
9MP0008058_abnormal_DNA_repair2.98769665
10MP0002161_abnormal_fertility/fecundity2.96321731
11MP0000653_abnormal_sex_gland2.85005187
12MP0000678_abnormal_parathyroid_gland2.79126714
13MP0003693_abnormal_embryo_hatching2.75491537
14MP0008057_abnormal_DNA_replication2.68825043
15MP0001486_abnormal_startle_reflex2.65859489
16MP0003111_abnormal_nucleus_morphology2.65169629
17MP0003806_abnormal_nucleotide_metabolis2.41054546
18MP0003077_abnormal_cell_cycle2.25350000
19MP0004957_abnormal_blastocyst_morpholog2.22649446
20MP0002132_abnormal_respiratory_system2.19100523
21MP0002160_abnormal_reproductive_system2.13429854
22MP0005310_abnormal_salivary_gland2.09783407
23MP0005670_abnormal_white_adipose2.04736134
24MP0005410_abnormal_fertilization11.8904419
25MP0002249_abnormal_larynx_morphology1.89245594
26MP0000534_abnormal_ureter_morphology1.82532378
27MP0005423_abnormal_somatic_nervous1.82391868
28MP0000015_abnormal_ear_pigmentation1.79152691
29MP0005551_abnormal_eye_electrophysiolog1.64921364
30MP0003786_premature_aging1.54177125
31MP0008007_abnormal_cellular_replicative1.52513013
32MP0004133_heterotaxia1.50812257
33MP0002234_abnormal_pharynx_morphology1.49863299
34MP0002735_abnormal_chemical_nociception1.48774241
35MP0001968_abnormal_touch/_nociception1.46788265
36MP0002127_abnormal_cardiovascular_syste1.43767830
37MP0001730_embryonic_growth_arrest1.42416659
38MP0008932_abnormal_embryonic_tissue1.40004847
39MP0005499_abnormal_olfactory_system1.39665841
40MP0005394_taste/olfaction_phenotype1.39665841
41MP0001963_abnormal_hearing_physiology1.39361732
42MP0003123_paternal_imprinting1.39342641
43MP0005623_abnormal_meninges_morphology1.36216608
44MP0000516_abnormal_urinary_system1.34898438
45MP0005367_renal/urinary_system_phenotyp1.34898438
46MP0005389_reproductive_system_phenotype1.33506845
47MP0004742_abnormal_vestibular_system1.32206528
48MP0008995_early_reproductive_senescence1.30723320
49MP0010307_abnormal_tumor_latency1.25714697
50MP0005379_endocrine/exocrine_gland_phen1.18301086
51MP0004233_abnormal_muscle_weight1.17022669
52MP0000350_abnormal_cell_proliferation1.13631407
53MP0001485_abnormal_pinna_reflex1.12189317
54MP0001984_abnormal_olfaction1.11782360
55MP0003718_maternal_effect1.10346312
56MP0003646_muscle_fatigue1.10244100
57MP0002254_reproductive_system_inflammat1.07404049
58MP0005083_abnormal_biliary_tract1.06937947
59MP0002084_abnormal_developmental_patter1.00207715
60MP0001905_abnormal_dopamine_level0.98768622
61MP0005380_embryogenesis_phenotype0.97564017
62MP0001672_abnormal_embryogenesis/_devel0.97564017
63MP0004510_myositis0.97295931
64MP0000569_abnormal_digit_pigmentation0.97199134
65MP0008789_abnormal_olfactory_epithelium0.96899642
66MP0001293_anophthalmia0.96536458
67MP0001697_abnormal_embryo_size0.95999251
68MP0001119_abnormal_female_reproductive0.94414982
69MP0004782_abnormal_surfactant_physiolog0.93798391
70MP0002085_abnormal_embryonic_tissue0.93237981
71MP0002282_abnormal_trachea_morphology0.90931223
72MP0010352_gastrointestinal_tract_polyps0.90664516
73MP0000470_abnormal_stomach_morphology0.88891363
74MP0003283_abnormal_digestive_organ0.88828155
75MP0003172_abnormal_lysosome_physiology0.88068536
76MP0001270_distended_abdomen0.87575816
77MP0000026_abnormal_inner_ear0.86336826
78MP0000358_abnormal_cell_content/0.85818214
79MP0002080_prenatal_lethality0.85682694
80MP0002733_abnormal_thermal_nociception0.84732811
81MP0005647_abnormal_sex_gland0.84265084
82MP0000313_abnormal_cell_death0.81975122
83MP0003699_abnormal_female_reproductive0.80800772
84MP0000955_abnormal_spinal_cord0.80515114
85MP0005248_abnormal_Harderian_gland0.78679619
86MP0002095_abnormal_skin_pigmentation0.77963234
87MP0005174_abnormal_tail_pigmentation0.77748296
88MP0003890_abnormal_embryonic-extraembry0.77727766
89MP0003787_abnormal_imprinting0.77492261
90MP0003984_embryonic_growth_retardation0.76109588
91MP0000681_abnormal_thyroid_gland0.74702958
92MP0005646_abnormal_pituitary_gland0.73855411
93MP0004197_abnormal_fetal_growth/weight/0.72783383
94MP0002088_abnormal_embryonic_growth/wei0.72377588
95MP0002971_abnormal_brown_adipose0.71999344
96MP0002229_neurodegeneration0.70455889
97MP0002734_abnormal_mechanical_nocicepti0.70359174
98MP0001879_abnormal_lymphatic_vessel0.70293608
99MP0003121_genomic_imprinting0.69494697
100MP0002557_abnormal_social/conspecific_i0.68585919
101MP0005266_abnormal_metabolism0.68303534
102MP0003315_abnormal_perineum_morphology0.66880631
103MP0005451_abnormal_body_composition0.66375198
104MP0002269_muscular_atrophy0.65544589
105MP0001849_ear_inflammation0.64623347
106MP0003195_calcinosis0.64106644
107MP0001666_abnormal_nutrient_absorption0.63805270
108MP0002572_abnormal_emotion/affect_behav0.63586309
109MP0000049_abnormal_middle_ear0.63385559
110MP0002086_abnormal_extraembryonic_tissu0.63276328
111MP0006036_abnormal_mitochondrial_physio0.62911691
112MP0003942_abnormal_urinary_system0.62535595
113MP0003136_yellow_coat_color0.61706428
114MP0003119_abnormal_digestive_system0.61616346
115MP0006035_abnormal_mitochondrial_morpho0.59829911
116MP0005636_abnormal_mineral_homeostasis0.59824177
117MP0002067_abnormal_sensory_capabilities0.59611346
118MP0002019_abnormal_tumor_incidence0.58468251
119MP0009053_abnormal_anal_canal0.58147669
120MP0003879_abnormal_hair_cell0.57685355
121MP0003878_abnormal_ear_physiology0.57389336
122MP0005377_hearing/vestibular/ear_phenot0.57389336
123MP0001970_abnormal_pain_threshold0.57136993
124MP0009115_abnormal_fat_cell0.56696604
125MP0006072_abnormal_retinal_apoptosis0.54946479
126MP0001501_abnormal_sleep_pattern0.53618594
127MP0004085_abnormal_heartbeat0.53091244
128MP0005075_abnormal_melanosome_morpholog0.52764976
129MP0003861_abnormal_nervous_system0.52094806
130MP0003936_abnormal_reproductive_system0.51240510
131MP0002928_abnormal_bile_duct0.50517024
132MP0004859_abnormal_synaptic_plasticity0.49401864
133MP0010329_abnormal_lipoprotein_level0.48753766
134MP0003943_abnormal_hepatobiliary_system0.48495205
135MP0001664_abnormal_digestion0.48042528
136MP0002138_abnormal_hepatobiliary_system0.47650894
137MP0001919_abnormal_reproductive_system0.47106371
138MP0005645_abnormal_hypothalamus_physiol0.46371468
139MP0003950_abnormal_plasma_membrane0.46221704
140MP0005076_abnormal_cell_differentiation0.46016653
141MP0008875_abnormal_xenobiotic_pharmacok0.44762112
142MP0001764_abnormal_homeostasis0.43979707
143MP0002736_abnormal_nociception_after0.43705091
144MP0000427_abnormal_hair_cycle0.42138875
145MP0003385_abnormal_body_wall0.41836244
146MP0005666_abnormal_adipose_tissue0.41111103
147MP0003115_abnormal_respiratory_system0.38397885
148MP0005391_vision/eye_phenotype0.38324726
149MP0005395_other_phenotype0.37881111
150MP0005384_cellular_phenotype0.37533562
151MP0002102_abnormal_ear_morphology0.37365061
152MP0003186_abnormal_redox_activity0.35338111
153MP0003941_abnormal_skin_development0.34977156
154MP0005253_abnormal_eye_physiology0.34703430
155MP0001765_abnormal_ion_homeostasis0.34271324
156MP0002092_abnormal_eye_morphology0.33269495
157MP0005397_hematopoietic_system_phenotyp0.31332004
158MP0001545_abnormal_hematopoietic_system0.31332004
159MP0009703_decreased_birth_body0.30039652
160MP0001986_abnormal_taste_sensitivity0.29890542
161MP0000432_abnormal_head_morphology0.28661566
162MP0003011_delayed_dark_adaptation0.28195247
163MP0004808_abnormal_hematopoietic_stem0.26933394
164MP0004264_abnormal_extraembryonic_tissu0.26607906
165MP0002169_no_abnormal_phenotype0.26448593
166MP0002873_normal_phenotype0.25960544
167MP0009046_muscle_twitch0.23955251
168MP0001727_abnormal_embryo_implantation0.23595939
169MP0009672_abnormal_birth_weight0.23438827
170MP0002796_impaired_skin_barrier0.23306148
171MP0005621_abnormal_cell_physiology0.22924661

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)8.35860919
2Abnormal respiratory motile cilium morphology (HP:0005938)8.15298769
3Abnormal respiratory epithelium morphology (HP:0012253)8.15298769
4Severe visual impairment (HP:0001141)7.08969962
5Rhinitis (HP:0012384)6.89135353
6Chronic bronchitis (HP:0004469)6.81247928
7Abnormal ciliary motility (HP:0012262)6.72390163
8Attenuation of retinal blood vessels (HP:0007843)5.86331740
9Chronic hepatic failure (HP:0100626)5.72388836
10Infertility (HP:0000789)5.60290561
11Nasal polyposis (HP:0100582)5.19862166
12Bony spicule pigmentary retinopathy (HP:0007737)4.75428663
13Abnormality of the nasal mucosa (HP:0000433)4.15389078
14Bronchiectasis (HP:0002110)3.90260160
15Bronchitis (HP:0012387)3.80689383
16Abnormal rod and cone electroretinograms (HP:0008323)3.77152642
17Male infertility (HP:0003251)3.74178712
18Abnormal spermatogenesis (HP:0008669)3.68954491
19Nephronophthisis (HP:0000090)3.65707792
20Cheilitis (HP:0100825)3.51617817
21Asymmetric septal hypertrophy (HP:0001670)3.51487241
22Cone-rod dystrophy (HP:0000548)3.51103401
23Aplasia/Hypoplasia of the earlobes (HP:0009906)3.50789240
24Hyperkalemia (HP:0002153)3.48899678
25Impulsivity (HP:0100710)3.47990094
26Abnormality of macular pigmentation (HP:0008002)3.34643144
27Enlarged epiphyses (HP:0010580)3.24965310
28Supernumerary spleens (HP:0009799)3.21757991
29Bell-shaped thorax (HP:0001591)3.04153731
30Hypoplasia of the thymus (HP:0000778)2.98326768
31Resting tremor (HP:0002322)2.93943615
32Facial shape deformation (HP:0011334)2.86273164
33Potter facies (HP:0002009)2.86273164
34Abnormality of dental color (HP:0011073)2.81667559
35Aplasia/Hypoplasia of the sacrum (HP:0008517)2.81237570
36Chronic mucocutaneous candidiasis (HP:0002728)2.80107064
37Recurrent cutaneous fungal infections (HP:0011370)2.80107064
38Amelogenesis imperfecta (HP:0000705)2.78329670
39Progressive cerebellar ataxia (HP:0002073)2.78117747
40Abnormality of the renal medulla (HP:0100957)2.76612270
41Decreased central vision (HP:0007663)2.75316999
42Recurrent sinusitis (HP:0011108)2.74429048
43Hyperthyroidism (HP:0000836)2.74032075
44Azoospermia (HP:0000027)2.71886263
45Recurrent otitis media (HP:0000403)2.70462209
46Seborrheic dermatitis (HP:0001051)2.69188704
47Bowel incontinence (HP:0002607)2.65903848
48Hypoplastic ischia (HP:0003175)2.65468295
49Postural instability (HP:0002172)2.56627249
50Generalized aminoaciduria (HP:0002909)2.55681419
51Unilateral renal agenesis (HP:0000122)2.55651803
52Renal dysplasia (HP:0000110)2.55307228
53Atelectasis (HP:0100750)2.54757227
54Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.54511474
55Medial flaring of the eyebrow (HP:0010747)2.54423425
56Tubulointerstitial nephritis (HP:0001970)2.53600781
57Molar tooth sign on MRI (HP:0002419)2.46148735
58Abnormality of midbrain morphology (HP:0002418)2.46148735
59Insulin-resistant diabetes mellitus (HP:0000831)2.45335765
60Abnormality of the lower motor neuron (HP:0002366)2.45290623
61Gonadotropin excess (HP:0000837)2.41737263
62Type II lissencephaly (HP:0007260)2.41630246
63Abnormal large intestine physiology (HP:0012700)2.41193584
64Abnormality of the ischium (HP:0003174)2.39065940
65Double outlet right ventricle (HP:0001719)2.38732579
66Congenital malformation of the right heart (HP:0011723)2.38732579
67Renovascular hypertension (HP:0100817)2.35485922
68Hypoalphalipoproteinemia (HP:0003233)2.34587561
69Anomalous pulmonary venous return (HP:0010772)2.34185643
70Breast hypoplasia (HP:0003187)2.24758461
71Osteomalacia (HP:0002749)2.22537902
72Birth length less than 3rd percentile (HP:0003561)2.20186117
73Ventricular tachycardia (HP:0004756)2.18581700
74Tubular atrophy (HP:0000092)2.18532787
75Hypoparathyroidism (HP:0000829)2.17581286
76Occipital encephalocele (HP:0002085)2.16435455
77Myokymia (HP:0002411)2.15594437
78Spastic paraparesis (HP:0002313)2.15432359
79Portal hypertension (HP:0001409)2.13378402
80Horizontal nystagmus (HP:0000666)2.11270139
81Bradycardia (HP:0001662)2.07982352
82Retinal dysplasia (HP:0007973)2.07813411
83Abnormality of the parathyroid morphology (HP:0011766)2.07635568
84Abnormal urine output (HP:0012590)2.05682249
85Menstrual irregularities (HP:0000858)2.04411859
86Progressive sensorineural hearing impairment (HP:0000408)2.02694026
87Enlarged kidneys (HP:0000105)2.02043476
88Intellectual disability, moderate (HP:0002342)2.00249882
89Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.0510102
90Dynein arm defect of respiratory motile cilia (HP:0012255)11.5626881
91Absent/shortened dynein arms (HP:0200106)11.5626881
92Facial cleft (HP:0002006)1.99915807
93Progressive muscle weakness (HP:0003323)1.98544644
94Hypoplasia of the capital femoral epiphysis (HP:0003090)1.96609817
95Abnormality of the pulmonary veins (HP:0011718)1.96403641
96Abnormal drinking behavior (HP:0030082)1.94924470
97Polydipsia (HP:0001959)1.94924470
98Short ribs (HP:0000773)1.93951014
99Abnormality of the hepatic vasculature (HP:0006707)1.92935573
100Abnormality of renal excretion (HP:0011036)1.92790885
101Optic nerve hypoplasia (HP:0000609)1.92142227
102Decreased electroretinogram (ERG) amplitude (HP:0000654)1.90820134
103Ependymoma (HP:0002888)1.90501613
104Bulbous nose (HP:0000414)1.90350630
105Truncal obesity (HP:0001956)1.89513930
106Heterotopia (HP:0002282)1.89399288
107Truncus arteriosus (HP:0001660)1.88532052
108Abnormality of the aortic arch (HP:0012303)1.88274175
109Congenital primary aphakia (HP:0007707)1.86286578
110Sloping forehead (HP:0000340)1.86000131
111Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.85302067
112Tetany (HP:0001281)1.85272209
113Absent thumb (HP:0009777)1.84520158
114Polycystic kidney dysplasia (HP:0000113)1.83571866
115Gait imbalance (HP:0002141)1.82729663
116Amyotrophic lateral sclerosis (HP:0007354)1.82659171
117Abnormality of potassium homeostasis (HP:0011042)1.81152757
118Aplasia/Hypoplasia of the uvula (HP:0010293)1.80445531
119Recurrent bronchitis (HP:0002837)1.80317019
120Selective tooth agenesis (HP:0001592)1.79300967
121Medulloblastoma (HP:0002885)1.78770475
122Postaxial foot polydactyly (HP:0001830)1.77841840
123Tubulointerstitial abnormality (HP:0001969)1.77485955
124Abnormality of the labia minora (HP:0012880)1.73581392
125Degeneration of anterior horn cells (HP:0002398)1.70952635
126Abnormality of the anterior horn cell (HP:0006802)1.70952635
127Meckel diverticulum (HP:0002245)1.70824442
128Aplasia/hypoplasia of the humerus (HP:0006507)1.70458760
129Abnormality of chromosome stability (HP:0003220)1.68533786
130Chromsome breakage (HP:0040012)1.67944753
131Abnormality of the preputium (HP:0100587)1.67072801
132Chromosomal breakage induced by crosslinking agents (HP:0003221)1.66698438
133Short humerus (HP:0005792)1.66077576
134Poor coordination (HP:0002370)1.64139443
135Nephrogenic diabetes insipidus (HP:0009806)1.62754661
136Abnormality of the ileum (HP:0001549)1.61396454
137Fibular hypoplasia (HP:0003038)1.60197895
138Pancreatic fibrosis (HP:0100732)1.60068576
139Congenital hepatic fibrosis (HP:0002612)1.59722055
140Carpal bone hypoplasia (HP:0001498)1.59025953
141Abnormality of abdominal situs (HP:0011620)1.58726664
142Abdominal situs inversus (HP:0003363)1.58726664
143Agnosia (HP:0010524)1.57918047
144Absent radius (HP:0003974)1.57781528
145Ectopic kidney (HP:0000086)1.57173934
146Oculomotor apraxia (HP:0000657)1.56080509
147Neoplasm of the oral cavity (HP:0100649)1.55682529
148Tongue fasciculations (HP:0001308)1.55177986
149Median cleft lip (HP:0000161)1.53892284
150Breast carcinoma (HP:0003002)1.52756275
151Postaxial hand polydactyly (HP:0001162)1.49884597
152Small intestinal stenosis (HP:0012848)1.49715516
153Duodenal stenosis (HP:0100867)1.49715516
154Abnormality of the renal cortex (HP:0011035)1.48124543
155Absent epiphyses (HP:0010577)1.48064380
156Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.48064380
157Absent forearm bone (HP:0003953)1.47456099
158Aplasia involving forearm bones (HP:0009822)1.47456099
159Pancreatic cysts (HP:0001737)1.46428763
160Cystic liver disease (HP:0006706)1.46131046
161Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.41971577
162Spastic tetraparesis (HP:0001285)1.39549969
163Cleft eyelid (HP:0000625)1.38619673
164Stage 5 chronic kidney disease (HP:0003774)1.37219079
165Hypoplasia of the radius (HP:0002984)1.36003419
166Muscle fibrillation (HP:0010546)1.35151070
167Abnormal biliary tract physiology (HP:0012439)1.35045526
168Bile duct proliferation (HP:0001408)1.35045526
169Nephroblastoma (Wilms tumor) (HP:0002667)1.33859077
170Aplasia/Hypoplasia of the sternum (HP:0006714)1.33026443
171Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.32724681
172Long foot (HP:0001833)1.32131450
173Abnormality of the dental root (HP:0006486)1.30714746
174Taurodontia (HP:0000679)1.30714746
175Abnormality of permanent molar morphology (HP:0011071)1.30714746

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK47.65298550
2PDK37.65298550
3PDK25.17393639
4INSRR4.74192737
5TESK14.44496597
6MAP4K23.29448492
7PLK23.01625726
8PRKD32.97353550
9DDR22.91357508
10PNCK2.87105382
11ICK2.83327731
12CAMK1G2.53981522
13NEK22.50514998
14WEE12.48388244
15TTK2.40924455
16CDC72.35900304
17BUB11.94889523
18PLK41.68804043
19PIK3CG1.53505473
20DYRK31.47598109
21MST1R1.43184116
22BMPR1B1.41381602
23PLK11.40443248
24CDK121.40293019
25TESK21.38528827
26CHEK21.36287739
27NEK11.35519378
28EIF2AK11.33416166
29STK381.26016822
30PASK1.22717503
31WNK41.18478412
32PTK2B1.18424033
33STK391.14069637
34ATR1.07452642
35KSR11.06760537
36AKT31.06707259
37BRSK21.04232776
38CASK1.03709831
39MARK11.02628420
40TIE11.02622642
41STK38L1.01545310
42CHEK10.97809280
43NTRK30.96250297
44VRK20.93082452
45ACVR1B0.91611123
46DYRK1B0.91479447
47NEK90.88382129
48MAP3K90.83370363
49MAP3K20.80477075
50ATM0.77683406
51AURKA0.76153816
52KSR20.74996808
53PLK30.74775117
54BRAF0.72978267
55IRAK10.72691126
56SGK20.71802619
57EPHA20.71578757
58AURKB0.69553054
59STK30.68463345
60SRPK10.68049856
61PBK0.66957451
62MUSK0.66725829
63CCNB10.65391909
64MAP2K20.64657233
65CDK70.64591522
66MAPKAPK30.62530002
67TYRO30.59601995
68CDK30.59365960
69PDK10.59355318
70SGK4940.58624389
71SGK2230.58624389
72NUAK10.55547961
73PAK40.54084678
74RPS6KB20.53470044
75SGK10.52797917
76EIF2AK30.52760727
77PAK10.51769468
78CDK20.50112751
79PRKG10.49571980
80BRSK10.48317943
81MAP3K80.47801850
82CDK40.46905059
83ADRBK10.45033481
84IRAK30.44397360
85MAP2K60.43900676
86UHMK10.43565720
87FRK0.43403768
88TSSK60.43207637
89VRK10.43199726
90PRKAA20.43063383
91CAMK10.42937176
92STK100.42510149
93CSNK2A20.41997455
94STK110.41460487
95OXSR10.40896917
96PRKG20.40663358
97STK160.40425729
98MAP3K40.39366268
99CSNK2A10.38775456
100ERN10.38722787
101RPS6KC10.38548176
102RPS6KL10.38548176
103MTOR0.38543395
104LMTK20.38275122
105WNK10.37939691
106RPS6KA60.37893584
107CDK10.37666568
108CDK90.36354854
109MAP3K110.35930151
110SGK30.35393655
111ROCK10.35314782
112BMX0.34885259
113STK40.34556759
114EEF2K0.34539073
115CSNK1D0.33611270
116ZAK0.32553442
117AKT10.32123752
118MAPK10.30581413
119RPS6KA20.29459673
120CSF1R0.28602145
121TLK10.27629734
122BRD40.26998723
123PKN10.26866715
124CSNK1E0.26221116
125MAPKAPK50.25530731
126MET0.25468444
127DYRK20.24190947
128RPS6KA40.23540022
129CAMK40.23171837
130PRKDC0.22435576
131FGR0.22410776
132MAPK150.21846244
133TNK20.21766068
134WNK30.20773456
135TGFBR10.20522314
136NEK60.19672378
137IRAK20.19445726
138GSK3B0.19346112
139MELK0.18938510
140PRKCZ0.18803405
141RET0.17855447
142MARK30.17247558
143PRKCI0.16429157
144PIM10.15409815
145RPS6KB10.14325001
146TAOK20.13640563
147PRKCG0.12845065
148CDK60.12491404
149TAF10.11843274
150PRKAA10.11286905
151YES10.09641525
152PDPK10.08809257
153PINK10.08635673
154CDK150.08426994
155LATS20.07902662
156RPS6KA10.07434244
157LATS10.07360662
158CDK11A0.06594264
159MAPK100.05881910
160CDK180.05833681

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000726.80013201
2Butanoate metabolism_Homo sapiens_hsa006504.96947296
3DNA replication_Homo sapiens_hsa030303.67426031
4Olfactory transduction_Homo sapiens_hsa047403.57043154
5Basal transcription factors_Homo sapiens_hsa030223.55120684
6Mismatch repair_Homo sapiens_hsa034303.48421849
7Fanconi anemia pathway_Homo sapiens_hsa034603.28558388
8RNA transport_Homo sapiens_hsa030133.26237580
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.13966731
10Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.05056364
11Vitamin B6 metabolism_Homo sapiens_hsa007502.82165344
12Homologous recombination_Homo sapiens_hsa034402.57993791
13Pyruvate metabolism_Homo sapiens_hsa006202.55114039
14Phototransduction_Homo sapiens_hsa047442.40832848
15Spliceosome_Homo sapiens_hsa030402.26917791
16Proteasome_Homo sapiens_hsa030502.18123917
17Oocyte meiosis_Homo sapiens_hsa041142.15787074
18mRNA surveillance pathway_Homo sapiens_hsa030152.14101916
19Cell cycle_Homo sapiens_hsa041102.13948318
20Nucleotide excision repair_Homo sapiens_hsa034202.13069666
21Selenocompound metabolism_Homo sapiens_hsa004502.09931693
22Pyrimidine metabolism_Homo sapiens_hsa002402.02278727
23Base excision repair_Homo sapiens_hsa034102.01575473
24Non-homologous end-joining_Homo sapiens_hsa034501.94564285
25Taste transduction_Homo sapiens_hsa047421.89767470
26Phenylalanine metabolism_Homo sapiens_hsa003601.89071884
27Fatty acid biosynthesis_Homo sapiens_hsa000611.85355149
28Propanoate metabolism_Homo sapiens_hsa006401.78946766
29RNA polymerase_Homo sapiens_hsa030201.74504574
30Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.72429352
31Cysteine and methionine metabolism_Homo sapiens_hsa002701.71410390
32Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.71371519
33Linoleic acid metabolism_Homo sapiens_hsa005911.70895262
34One carbon pool by folate_Homo sapiens_hsa006701.69493485
35Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.69055180
36Purine metabolism_Homo sapiens_hsa002301.67933720
37Steroid hormone biosynthesis_Homo sapiens_hsa001401.67422025
38Huntingtons disease_Homo sapiens_hsa050161.66694058
39alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.64245785
40Pentose phosphate pathway_Homo sapiens_hsa000301.61022675
41Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.57357875
42RNA degradation_Homo sapiens_hsa030181.56802151
43Glucagon signaling pathway_Homo sapiens_hsa049221.52129444
44Tyrosine metabolism_Homo sapiens_hsa003501.49412473
45Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.45810237
46Biosynthesis of amino acids_Homo sapiens_hsa012301.42344485
47Carbon metabolism_Homo sapiens_hsa012001.28383714
48Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.17573773
49Arginine biosynthesis_Homo sapiens_hsa002201.15559865
50Glutamatergic synapse_Homo sapiens_hsa047241.13850048
51Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.10492259
52Fructose and mannose metabolism_Homo sapiens_hsa000511.10450496
53Glutathione metabolism_Homo sapiens_hsa004801.09226880
54Type II diabetes mellitus_Homo sapiens_hsa049301.08889500
55Ribosome_Homo sapiens_hsa030101.08674406
56Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.07755315
57Antigen processing and presentation_Homo sapiens_hsa046121.03401007
58p53 signaling pathway_Homo sapiens_hsa041151.02586537
59Systemic lupus erythematosus_Homo sapiens_hsa053221.00744233
60Glycosaminoglycan degradation_Homo sapiens_hsa005310.96014192
61Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.93105783
62Allograft rejection_Homo sapiens_hsa053300.93020186
63Autoimmune thyroid disease_Homo sapiens_hsa053200.93008332
64Type I diabetes mellitus_Homo sapiens_hsa049400.92554416
65Pentose and glucuronate interconversions_Homo sapiens_hsa000400.91062262
66Retinol metabolism_Homo sapiens_hsa008300.89829556
67Glycerolipid metabolism_Homo sapiens_hsa005610.89494710
68Calcium signaling pathway_Homo sapiens_hsa040200.86882238
69Salivary secretion_Homo sapiens_hsa049700.85389893
70Phosphatidylinositol signaling system_Homo sapiens_hsa040700.83021500
71NOD-like receptor signaling pathway_Homo sapiens_hsa046210.81117055
72Cardiac muscle contraction_Homo sapiens_hsa042600.80362908
73Epstein-Barr virus infection_Homo sapiens_hsa051690.78488738
74Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.78368940
75Arginine and proline metabolism_Homo sapiens_hsa003300.76686292
76Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.74821998
77ABC transporters_Homo sapiens_hsa020100.73358765
78Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.72961072
79Graft-versus-host disease_Homo sapiens_hsa053320.72407500
80Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.70326129
81Carbohydrate digestion and absorption_Homo sapiens_hsa049730.68857923
82Glycerophospholipid metabolism_Homo sapiens_hsa005640.68497418
83Dorso-ventral axis formation_Homo sapiens_hsa043200.65945209
84Pancreatic secretion_Homo sapiens_hsa049720.65742430
85Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.63153635
86Viral myocarditis_Homo sapiens_hsa054160.61594605
87Morphine addiction_Homo sapiens_hsa050320.58764087
88Nitrogen metabolism_Homo sapiens_hsa009100.58680268
89Ether lipid metabolism_Homo sapiens_hsa005650.58670197
90Vitamin digestion and absorption_Homo sapiens_hsa049770.58139294
91Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.57781034
92Viral carcinogenesis_Homo sapiens_hsa052030.56751236
93cAMP signaling pathway_Homo sapiens_hsa040240.56247899
94Mineral absorption_Homo sapiens_hsa049780.53219165
95Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.53084604
96Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.52283825
97Amphetamine addiction_Homo sapiens_hsa050310.51289841
98Circadian entrainment_Homo sapiens_hsa047130.49898568
99Hedgehog signaling pathway_Homo sapiens_hsa043400.49740171
100Endocytosis_Homo sapiens_hsa041440.48154554
101Metabolic pathways_Homo sapiens_hsa011000.48030058
102PPAR signaling pathway_Homo sapiens_hsa033200.47497441
103Serotonergic synapse_Homo sapiens_hsa047260.46684300
104Adipocytokine signaling pathway_Homo sapiens_hsa049200.46395330
105Arachidonic acid metabolism_Homo sapiens_hsa005900.44455930
106Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.43845561
107Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.43516297
108Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.41764802
109Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.40921125
110Bile secretion_Homo sapiens_hsa049760.40101236
111Fat digestion and absorption_Homo sapiens_hsa049750.39162539
112Acute myeloid leukemia_Homo sapiens_hsa052210.38855709
113Alcoholism_Homo sapiens_hsa050340.38185100
114Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.38083046
115Nicotine addiction_Homo sapiens_hsa050330.37110630
116Cyanoamino acid metabolism_Homo sapiens_hsa004600.36711781
117Influenza A_Homo sapiens_hsa051640.35557319
118Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.35477035
119Chemical carcinogenesis_Homo sapiens_hsa052040.34794554
120Lysine degradation_Homo sapiens_hsa003100.34132441
121Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.34099609
122beta-Alanine metabolism_Homo sapiens_hsa004100.33757553
123Synaptic vesicle cycle_Homo sapiens_hsa047210.33109871
124Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.33109087
125Primary bile acid biosynthesis_Homo sapiens_hsa001200.32648866
126Peroxisome_Homo sapiens_hsa041460.31892282
127Drug metabolism - other enzymes_Homo sapiens_hsa009830.31396429
128Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.31221961
129Central carbon metabolism in cancer_Homo sapiens_hsa052300.31188395
130Renin-angiotensin system_Homo sapiens_hsa046140.31066901
131Collecting duct acid secretion_Homo sapiens_hsa049660.29158347
132Ovarian steroidogenesis_Homo sapiens_hsa049130.28332906
133Vascular smooth muscle contraction_Homo sapiens_hsa042700.27084802
134VEGF signaling pathway_Homo sapiens_hsa043700.26434021
135Insulin secretion_Homo sapiens_hsa049110.25749774
136Prolactin signaling pathway_Homo sapiens_hsa049170.25703589
137HTLV-I infection_Homo sapiens_hsa051660.25066974
138Parkinsons disease_Homo sapiens_hsa050120.24488020
139Legionellosis_Homo sapiens_hsa051340.23512587
140Oxidative phosphorylation_Homo sapiens_hsa001900.22930135
141Fatty acid degradation_Homo sapiens_hsa000710.19745635
142Herpes simplex infection_Homo sapiens_hsa051680.19588813
143Basal cell carcinoma_Homo sapiens_hsa052170.19316333
144Inositol phosphate metabolism_Homo sapiens_hsa005620.15846838
145Tight junction_Homo sapiens_hsa045300.15751936
146Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.15166006
147Thyroid hormone signaling pathway_Homo sapiens_hsa049190.14910328
148Estrogen signaling pathway_Homo sapiens_hsa049150.13505990
149Hippo signaling pathway_Homo sapiens_hsa043900.10507545
150AMPK signaling pathway_Homo sapiens_hsa041520.09279453
151Folate biosynthesis_Homo sapiens_hsa007900.08675229
152Fatty acid metabolism_Homo sapiens_hsa012120.07849643
153Thyroid hormone synthesis_Homo sapiens_hsa049180.07631269
154Wnt signaling pathway_Homo sapiens_hsa043100.07607144
155Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.05408863
156Protein digestion and absorption_Homo sapiens_hsa049740.03884431

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