LRRK1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a multi-domain protein that is a leucine-rich repeat kinase and a GDP/GTP binding protein. The encoded protein is thought to play a role in the regulation of bone mass. Mice lacking a similar gene showed severe osteopetrosis, increased bone mineralization and decreased bone resorption. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pre-miRNA processing (GO:0031054)7.33862346
2positive regulation of SMAD protein import into nucleus (GO:0060391)6.38461054
3heterochromatin organization (GO:0070828)5.68037733
4protein complex localization (GO:0031503)5.59847428
5establishment of integrated proviral latency (GO:0075713)5.53833337
6L-serine metabolic process (GO:0006563)5.34833016
7regulation of gene silencing (GO:0060968)5.27942472
8negative regulation of gene silencing (GO:0060969)5.27140447
9regulation of histone H3-K9 methylation (GO:0051570)5.20114639
10regulation of cell fate specification (GO:0042659)5.17666471
11regulation of dendritic cell antigen processing and presentation (GO:0002604)5.11223780
12NIK/NF-kappaB signaling (GO:0038061)5.06930542
13DNA unwinding involved in DNA replication (GO:0006268)5.04910653
14regulation of Wnt signaling pathway involved in heart development (GO:0003307)5.02350548
15antigen processing and presentation of endogenous antigen (GO:0019883)4.98851780
16paraxial mesoderm development (GO:0048339)4.95041902
17regulation of chromatin silencing (GO:0031935)4.87264584
18antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.73673135
19nuclear pore complex assembly (GO:0051292)4.73457175
20protein localization to kinetochore (GO:0034501)4.69648013
21negative regulation of histone methylation (GO:0031061)4.59145555
22negative regulation of translation, ncRNA-mediated (GO:0040033)4.53687220
23regulation of translation, ncRNA-mediated (GO:0045974)4.53687220
24negative regulation of translation involved in gene silencing by miRNA (GO:0035278)4.53687220
25histone arginine methylation (GO:0034969)4.52291216
26regulation of SMAD protein import into nucleus (GO:0060390)4.50388334
27positive regulation of antigen processing and presentation (GO:0002579)4.38791640
28L-alpha-amino acid transmembrane transport (GO:1902475)4.38124201
29antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.36815962
30antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.36815962
31cell fate commitment involved in formation of primary germ layer (GO:0060795)4.31251718
32positive regulation of catenin import into nucleus (GO:0035413)4.23069141
33nuclear pore organization (GO:0006999)4.16475535
34lung-associated mesenchyme development (GO:0060484)4.08883192
35establishment of viral latency (GO:0019043)4.05229299
36regulation of antigen processing and presentation (GO:0002577)4.00425571
37IMP biosynthetic process (GO:0006188)3.97841059
38cellular protein complex localization (GO:0034629)3.91428023
39protein localization to chromosome, centromeric region (GO:0071459)3.88304446
40neutrophil activation involved in immune response (GO:0002283)3.88141517
41IMP metabolic process (GO:0046040)3.83797678
42negative regulation of androgen receptor signaling pathway (GO:0060766)3.82085227
43regulation of interleukin-12 biosynthetic process (GO:0045075)3.80273156
44positive regulation of natural killer cell differentiation (GO:0032825)3.79756495
45regulation of stem cell maintenance (GO:2000036)3.77151496
46regulation of helicase activity (GO:0051095)3.76177919
47myeloid dendritic cell differentiation (GO:0043011)3.74578337
48glomerular visceral epithelial cell development (GO:0072015)3.71520683
49response to muramyl dipeptide (GO:0032495)3.68948035
50protein-DNA complex disassembly (GO:0032986)3.63504342
51nucleosome disassembly (GO:0006337)3.63504342
52myeloid dendritic cell activation (GO:0001773)3.61899805
53growth hormone receptor signaling pathway (GO:0060396)3.60861634
54neutrophil activation (GO:0042119)3.50126424
55regulation of cell fate commitment (GO:0010453)3.48677815
56positive regulation of gamma-delta T cell activation (GO:0046645)3.48453388
57dendritic cell differentiation (GO:0097028)3.44208775
58convergent extension (GO:0060026)3.40818834
59positive regulation of cell cycle G2/M phase transition (GO:1902751)3.39904830
60positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)3.39904830
61anterior/posterior axis specification, embryo (GO:0008595)3.37402397
62nodal signaling pathway (GO:0038092)3.31780013
63notochord development (GO:0030903)3.30996399
64DNA strand elongation involved in DNA replication (GO:0006271)3.29585510
65pore complex assembly (GO:0046931)3.29509788
66cell adhesion mediated by integrin (GO:0033627)3.28332773
67positive regulation of interferon-alpha production (GO:0032727)3.28316493
68positive regulation of chromosome segregation (GO:0051984)3.28207099
69granulocyte activation (GO:0036230)3.26382118
70glomerular epithelial cell development (GO:0072310)3.25253408
71single strand break repair (GO:0000012)3.20992361
72mitotic sister chromatid cohesion (GO:0007064)3.17269061
73peptidyl-arginine omega-N-methylation (GO:0035247)3.15917710
74DNA strand elongation (GO:0022616)3.13584087
75DNA duplex unwinding (GO:0032508)3.12602928
76chromatin silencing (GO:0006342)3.12266303
77serine family amino acid biosynthetic process (GO:0009070)3.09234992
78positive regulation of B cell differentiation (GO:0045579)3.09103822
79DNA replication initiation (GO:0006270)3.08223027
80lysine catabolic process (GO:0006554)3.07846961
81lysine metabolic process (GO:0006553)3.07846961
82negative regulation of cell fate specification (GO:0009996)3.06997030
83regulation of interferon-alpha production (GO:0032647)3.06180307
84negative regulation of granulocyte differentiation (GO:0030853)3.06095769
85cellular response to growth hormone stimulus (GO:0071378)3.05903162
86negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.05189181
87histone H3-K36 demethylation (GO:0070544)3.04433992
88negative regulation of telomerase activity (GO:0051974)3.02879090
89DNA geometric change (GO:0032392)3.01243525
90establishment of apical/basal cell polarity (GO:0035089)3.00940442
91regulation of translational fidelity (GO:0006450)2.99893403
92antigen processing and presentation via MHC class Ib (GO:0002475)2.99003900
93regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.97776725
94negative regulation of chromosome segregation (GO:0051985)2.97512309
95natural killer cell mediated cytotoxicity (GO:0042267)2.95253012
96natural killer cell mediated immunity (GO:0002228)2.95253012
97positive regulation of interleukin-12 production (GO:0032735)2.95083554
98chromatin assembly (GO:0031497)2.94826026
99interferon-gamma-mediated signaling pathway (GO:0060333)2.93561567
100regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.92591223
101nucleobase biosynthetic process (GO:0046112)2.92577649
102negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.92575238
103negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.92575238
104negative regulation of mitotic sister chromatid segregation (GO:0033048)2.92575238
105negative regulation of mitotic sister chromatid separation (GO:2000816)2.92575238
106negative regulation of sister chromatid segregation (GO:0033046)2.92575238
107ATP-dependent chromatin remodeling (GO:0043044)2.91605908
108regulation of interferon-beta biosynthetic process (GO:0045357)2.91467624
109negative regulation of cell fate commitment (GO:0010454)2.91454445
110response to type I interferon (GO:0034340)2.91012513
111mitotic metaphase plate congression (GO:0007080)2.90289815
112regulation of telomere maintenance via telomerase (GO:0032210)2.89182176
113regulation of DNA methylation (GO:0044030)2.89134727
114immunoglobulin mediated immune response (GO:0016064)2.87301590
115somatic hypermutation of immunoglobulin genes (GO:0016446)2.87096411
116somatic diversification of immune receptors via somatic mutation (GO:0002566)2.87096411
117type I interferon signaling pathway (GO:0060337)2.85884917
118cellular response to type I interferon (GO:0071357)2.85884917
119regulation of catenin import into nucleus (GO:0035412)2.84243872
120planar cell polarity pathway involved in neural tube closure (GO:0090179)2.82096323
121mRNA stabilization (GO:0048255)2.81291706
122RNA stabilization (GO:0043489)2.81291706
123ncRNA catabolic process (GO:0034661)2.80180033
124regulation of necroptotic process (GO:0060544)2.80114272
125homocysteine metabolic process (GO:0050667)2.79673141
126regulation of chromosome segregation (GO:0051983)2.79545007
127NLS-bearing protein import into nucleus (GO:0006607)2.78552332
128regulation of B cell differentiation (GO:0045577)2.78479048
129regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.78355617
130regulation of natural killer cell differentiation (GO:0032823)2.77648800
131regulation of integrin activation (GO:0033623)2.77504013
132folic acid-containing compound biosynthetic process (GO:0009396)2.76844574
133regulation of B cell receptor signaling pathway (GO:0050855)2.76060065
134regulation of T-helper 1 cell differentiation (GO:0045625)2.75132083
135positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.74763247
136peptidyl-arginine methylation (GO:0018216)2.74717609
137peptidyl-arginine N-methylation (GO:0035246)2.74717609
138response to peptidoglycan (GO:0032494)2.73830944
139DNA replication checkpoint (GO:0000076)2.72270621
140JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.71068248
141DNA replication-dependent nucleosome organization (GO:0034723)2.70599605
142DNA replication-dependent nucleosome assembly (GO:0006335)2.70599605
143negative thymic T cell selection (GO:0045060)2.70127282
144hepatocyte apoptotic process (GO:0097284)2.68313247
145germinal center formation (GO:0002467)2.64274625
146regulation of interleukin-12 production (GO:0032655)2.63769242
147regulation of T cell tolerance induction (GO:0002664)2.63487640
148positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.63155239
149macrophage activation involved in immune response (GO:0002281)2.62676310
150regulation of RIG-I signaling pathway (GO:0039535)2.60928776
151modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.60161339
152positive regulation by organism of defense response of other organism involved in symbiotic interact2.60161339
153modulation by symbiont of host immune response (GO:0052553)2.60161339
154positive regulation by symbiont of host defense response (GO:0052509)2.60161339
155modulation by symbiont of host defense response (GO:0052031)2.60161339
156modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.60161339
157dendritic cell migration (GO:0036336)2.59043353
158dendritic cell chemotaxis (GO:0002407)2.53032134
159response to interferon-beta (GO:0035456)2.48448781
160regulation of cellular extravasation (GO:0002691)2.47175415
161Arp2/3 complex-mediated actin nucleation (GO:0034314)2.46990424
162regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.45308079
163positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.44686746
164negative T cell selection (GO:0043383)2.44551655
165mature B cell differentiation (GO:0002335)2.44524406
166cellular response to interferon-beta (GO:0035458)2.44222565
167regulation of hypersensitivity (GO:0002883)2.43692389
168cytokine secretion (GO:0050663)2.43613987
169substrate-dependent cell migration (GO:0006929)2.43480647
170natural killer cell differentiation (GO:0001779)2.42907453
171pinocytosis (GO:0006907)2.42696752
172positive regulation of granulocyte chemotaxis (GO:0071624)2.42054541
173positive regulation of neutrophil chemotaxis (GO:0090023)2.38647695
174positive regulation of neutrophil migration (GO:1902624)2.38647695
175cellular response to zinc ion (GO:0071294)2.38378219
176response to interferon-alpha (GO:0035455)2.37555758
177myeloid leukocyte activation (GO:0002274)2.37166841
178regulation of gamma-delta T cell activation (GO:0046643)2.35597465
179cellular extravasation (GO:0045123)2.34514147
180apoptotic cell clearance (GO:0043277)2.33627818
181T-helper 1 type immune response (GO:0042088)2.33215448
182cellular response to exogenous dsRNA (GO:0071360)2.32943166
183defense response to protozoan (GO:0042832)2.32182891
184positive regulation of monocyte chemotaxis (GO:0090026)2.31278547
185positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.30252634
186regulation of gamma-delta T cell differentiation (GO:0045586)2.30215116
187leukocyte mediated cytotoxicity (GO:0001909)2.29173715
188B cell mediated immunity (GO:0019724)2.27422095
189negative regulation of phagocytosis (GO:0050765)2.27116114
190positive regulation of natural killer cell activation (GO:0032816)2.27003160
191positive regulation of macrophage differentiation (GO:0045651)2.26897393
192response to protozoan (GO:0001562)2.26754638
193regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.24963532
194T cell migration (GO:0072678)2.24616719
195detection of molecule of bacterial origin (GO:0032490)2.24287326
196positive regulation of interferon-beta production (GO:0032728)2.23734864
197positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.23438421
198regulation of gene silencing by RNA (GO:0060966)10.1918546
199regulation of posttranscriptional gene silencing (GO:0060147)10.1918546
200regulation of gene silencing by miRNA (GO:0060964)10.1918546

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.73319493
2IRF8_22096565_ChIP-ChIP_GC-B_Human5.17861576
3KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.54209089
4KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.54209089
5KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.54209089
6IRF8_21731497_ChIP-ChIP_J774_Mouse4.23072483
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.20849320
8TP63_17297297_ChIP-ChIP_HaCaT_Human3.84256271
9FOXM1_23109430_ChIP-Seq_U2OS_Human3.83994896
10POU5F1_18700969_ChIP-ChIP_MESCs_Mouse3.46228515
11MYC_18555785_ChIP-Seq_MESCs_Mouse3.44566054
12STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.36137643
13EGR1_19374776_ChIP-ChIP_THP-1_Human3.32114703
14NANOG_18700969_ChIP-ChIP_MESCs_Mouse3.24558303
15IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.24478392
16IRF8_27001747_Chip-Seq_BMDM_Mouse3.20674839
17IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.17975498
18BP1_19119308_ChIP-ChIP_Hs578T_Human3.09245192
19NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.03291149
20RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.93606472
21SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.89293061
22MYC_19079543_ChIP-ChIP_MESCs_Mouse2.87768559
23NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.81918428
24E2F4_17652178_ChIP-ChIP_JURKAT_Human2.78306182
25STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.77538349
26ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.63710797
27MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.62601900
28KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.60821463
29TCF3_18692474_ChIP-Seq_MEFs_Mouse2.60213102
30NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.57756858
31FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.57269981
32STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.53712681
33MYB_21317192_ChIP-Seq_ERMYB_Mouse2.53367350
34ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.43741883
35SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.38494744
36* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.37189728
37MYC_19030024_ChIP-ChIP_MESCs_Mouse2.36191496
38EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.26663547
39SALL1_21062744_ChIP-ChIP_HESCs_Human2.25565691
40TCF3_18692474_ChIP-Seq_MESCs_Mouse2.16663734
41SOX2_16153702_ChIP-ChIP_HESCs_Human2.15016212
42RARG_19884340_ChIP-ChIP_MEFs_Mouse2.13683377
43NANOG_16153702_ChIP-ChIP_HESCs_Human2.11751794
44* SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.08380227
45SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.05211523
46ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.05079270
47NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.04533141
48SOX2_18555785_ChIP-Seq_MESCs_Mouse2.03930829
49TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.01497167
50NANOG_18555785_ChIP-Seq_MESCs_Mouse1.98604842
51POU5F1_16153702_ChIP-ChIP_HESCs_Human1.95412708
52RUNX_20019798_ChIP-Seq_JUKART_Human1.95366083
53STAT4_19710469_ChIP-ChIP_TH1__Mouse1.93190056
54SCL_19346495_ChIP-Seq_HPC-7_Human1.90852666
55GATA2_21666600_ChIP-Seq_HMVEC_Human1.90229854
56E2F1_21310950_ChIP-Seq_MCF-7_Human1.89821828
57BRD4_27068464_Chip-Seq_AML-cells_Mouse1.88550142
58GATA1_22025678_ChIP-Seq_K562_Human1.84419948
59GATA1_26923725_Chip-Seq_HPCs_Mouse1.83701233
60ZFP281_18757296_ChIP-ChIP_E14_Mouse1.81035865
61CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.81010732
62RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.79936560
63SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.79828619
64TRIM28_21343339_ChIP-Seq_HEK293_Human1.77307535
65VDR_21846776_ChIP-Seq_THP-1_Human1.76641361
66MAF_26560356_Chip-Seq_TH1_Human1.76623100
67VDR_24763502_ChIP-Seq_THP-1_Human1.76507139
68NELFA_20434984_ChIP-Seq_ESCs_Mouse1.75546735
69MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.74239938
70TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.73975847
71MYB_26560356_Chip-Seq_TH2_Human1.73821561
72POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.73394048
73MYCN_18555785_ChIP-Seq_MESCs_Mouse1.71327332
74VDR_24787735_ChIP-Seq_THP-1_Human1.63646338
75MYC_18358816_ChIP-ChIP_MESCs_Mouse1.63179292
76ELK3_25401928_ChIP-Seq_HUVEC_Human1.62273751
77TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.61554507
78NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.59988998
79FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.59435187
80STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.58872530
81SMAD_19615063_ChIP-ChIP_OVARY_Human1.57889015
82NANOG_21062744_ChIP-ChIP_HESCs_Human1.55956854
83RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.55026656
84POU5F1_16518401_ChIP-PET_MESCs_Mouse1.54822579
85THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.54612128
86SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.54139401
87SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.53521620
88SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.53521620
89SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.51626233
90VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.50862554
91CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.50858693
92SPI1_23127762_ChIP-Seq_K562_Human1.50342391
93AR_21909140_ChIP-Seq_LNCAP_Human1.49763562
94* SPI1_23547873_ChIP-Seq_NB4_Human1.49360822
95TCF7_22412390_ChIP-Seq_EML_Mouse1.48913683
96MYB_26560356_Chip-Seq_TH1_Human1.46042413
97RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.43152688
98CLOCK_20551151_ChIP-Seq_293T_Human1.42964044
99POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.42178322
100MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.41276533
101NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.40568970
102HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.40233852
103TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.39161035
104RUNX1_22412390_ChIP-Seq_EML_Mouse1.37462965
105PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.37187293
106RBPJ_22232070_ChIP-Seq_NCS_Mouse1.36165919
107KLF4_18555785_ChIP-Seq_MESCs_Mouse1.35253185
108MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.34932086
109YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.34686089
110ESR1_21235772_ChIP-Seq_MCF-7_Human1.34334515
111E2F1_18555785_ChIP-Seq_MESCs_Mouse1.34147484
112SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.33673964
113TBX3_20139965_ChIP-Seq_ESCs_Mouse1.32310132
114TBX3_20139965_ChIP-Seq_MESCs_Mouse1.30870098
115PU_27001747_Chip-Seq_BMDM_Mouse1.30673820
116SOX2_18692474_ChIP-Seq_MEFs_Mouse1.29326407
117SOX2_18692474_ChIP-Seq_MESCs_Mouse1.29119546
118ZFX_18555785_ChIP-Seq_MESCs_Mouse1.27965776
119KAP1_27257070_Chip-Seq_ESCs_Mouse1.27696206
120* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.25274549
121POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.25000531
122FOXO3_23340844_ChIP-Seq_DLD1_Human1.24682968
123ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.23881760
124* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.23004587
125* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.22978962
126NANOG_18692474_ChIP-Seq_MESCs_Mouse1.22191683
127PPARA_22158963_ChIP-Seq_LIVER_Mouse1.21882300
128* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.21183968
129PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.20853149
130CJUN_26792858_Chip-Seq_BT549_Human1.20271411
131CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.20106453
132* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.19988412
133ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.19980443
134UTX_26944678_Chip-Seq_JUKART_Human1.19557541
135MYC_22102868_ChIP-Seq_BL_Human1.19526411
136CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.19523618
137PPAR_26484153_Chip-Seq_NCI-H1993_Human1.18070420
138ERG_21242973_ChIP-ChIP_JURKAT_Human1.17541702
139NANOG_18692474_ChIP-Seq_MEFs_Mouse1.16857930
140ZFP281_27345836_Chip-Seq_ESCs_Mouse1.16753901
141NANOG_16518401_ChIP-PET_MESCs_Mouse1.16113409
142CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.15467524
143SOX2_20726797_ChIP-Seq_SW620_Human1.14826453
144LXR_22158963_ChIP-Seq_LIVER_Mouse1.14191337
145POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.14145790
146OCT4_18692474_ChIP-Seq_MEFs_Mouse1.12202623
147KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.11117646
148FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.10072198
149* NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.09710961
150NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.09290106
151XRN2_22483619_ChIP-Seq_HELA_Human1.09111550
152RXR_22158963_ChIP-Seq_LIVER_Mouse1.08650042
153JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.08081110
154GATA3_27048872_Chip-Seq_THYMUS_Human1.07826688
155ESR2_21235772_ChIP-Seq_MCF-7_Human1.07491336
156HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.06756625
157BRD4_25478319_ChIP-Seq_HGPS_Human1.06361480
158KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.05791990
159STAT3_1855785_ChIP-Seq_MESCs_Mouse1.05532353
160ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.04502616
161LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.04481446
162* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04376128
163CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04014416
164THAP11_20581084_ChIP-Seq_MESCs_Mouse1.02644838
165JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.02024820
166KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.01709296
167CDX2_20551321_ChIP-Seq_CACO-2_Human1.00280160
168CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.00067840
169GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.99916841
170DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.99527447
171P63_26484246_Chip-Seq_KERATINOCYTES_Human0.99262927
172HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.98308602
173NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.98153313
174KDM2B_26808549_Chip-Seq_DND41_Human0.97047094
175LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.96989392
176TTF2_22483619_ChIP-Seq_HELA_Human0.96968694
177GATA2_22383799_ChIP-Seq_G1ME_Mouse0.96951322
178TBX20_22080862_ChIP-Seq_HEART_Mouse0.96555447
179TBX20_22328084_ChIP-Seq_HEART_Mouse0.96555447
180MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.93333131
181WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.93252683
182TP63_19390658_ChIP-ChIP_HaCaT_Human0.92598831
183SOX9_24532713_ChIP-Seq_HFSC_Mouse0.92332753
184GATA2_19941826_ChIP-Seq_K562_Human0.92118792
185CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.91877795
186ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.91335255
187KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.91209558
188KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.91094780
189* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.88200005
190EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.85878816
191WT1_19549856_ChIP-ChIP_CCG9911_Human0.85459079
192ISL1_27105846_Chip-Seq_CPCs_Mouse0.84805922
193ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.84745664
194CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.84111954
195SOX17_20123909_ChIP-Seq_XEN_Mouse0.78868725
196STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.78448767
197PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.77178403
198* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.76655947

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.01934863
2MP0003941_abnormal_skin_development3.96437146
3MP0003693_abnormal_embryo_hatching3.61059407
4MP0008057_abnormal_DNA_replication3.60779775
5MP0004957_abnormal_blastocyst_morpholog3.51565302
6MP0003890_abnormal_embryonic-extraembry3.31098821
7MP0009672_abnormal_birth_weight3.19944492
8MP0000685_abnormal_immune_system3.17869039
9MP0003111_abnormal_nucleus_morphology3.08332922
10MP0002138_abnormal_hepatobiliary_system3.01651836
11MP0002254_reproductive_system_inflammat2.99350626
12MP0010094_abnormal_chromosome_stability2.63205748
13MP0008438_abnormal_cutaneous_collagen2.58108603
14MP0003718_maternal_effect2.50171167
15MP0008877_abnormal_DNA_methylation2.46196005
16MP0001790_abnormal_immune_system2.44714300
17MP0005387_immune_system_phenotype2.44714300
18MP0003436_decreased_susceptibility_to2.39670046
19MP0004510_myositis2.36847697
20MP0002166_altered_tumor_susceptibility2.36512972
21MP0001730_embryonic_growth_arrest2.33193344
22MP0005671_abnormal_response_to2.29180528
23MP0008932_abnormal_embryonic_tissue2.28835608
24MP0002148_abnormal_hypersensitivity_rea2.27031998
25MP0009785_altered_susceptibility_to2.19526185
26MP0003077_abnormal_cell_cycle2.14650848
27MP0001800_abnormal_humoral_immune2.07321446
28MP0002452_abnormal_antigen_presenting2.07179482
29MP0003136_yellow_coat_color2.05039351
30MP0002419_abnormal_innate_immunity2.04976954
31MP0003119_abnormal_digestive_system2.04140363
32MP0005000_abnormal_immune_tolerance2.01037659
33MP0002006_tumorigenesis1.98915765
34MP0000537_abnormal_urethra_morphology1.98545268
35MP0003705_abnormal_hypodermis_morpholog1.98288995
36MP0003937_abnormal_limbs/digits/tail_de1.95756637
37MP0003567_abnormal_fetal_cardiomyocyte1.95490726
38MP0005025_abnormal_response_to1.94926824
39MP0008058_abnormal_DNA_repair1.91774927
40MP0004133_heterotaxia1.88831451
41MP0001672_abnormal_embryogenesis/_devel1.87731794
42MP0005380_embryogenesis_phenotype1.87731794
43MP0002085_abnormal_embryonic_tissue1.86029812
44MP0001348_abnormal_lacrimal_gland1.84170502
45MP0003566_abnormal_cell_adhesion1.83543994
46MP0005275_abnormal_skin_tensile1.82350323
47MP0002723_abnormal_immune_serum1.80242829
48MP0001873_stomach_inflammation1.79679457
49MP0002697_abnormal_eye_size1.78607520
50MP0003191_abnormal_cellular_cholesterol1.77898475
51MP0010030_abnormal_orbit_morphology1.77374142
52MP0001853_heart_inflammation1.77369990
53MP0006082_CNS_inflammation1.75191134
54MP0002084_abnormal_developmental_patter1.74805155
55MP0001819_abnormal_immune_cell1.74132651
56MP0003300_gastrointestinal_ulcer1.73961458
57MP0002420_abnormal_adaptive_immunity1.71742725
58MP0005464_abnormal_platelet_physiology1.69557087
59MP0010352_gastrointestinal_tract_polyps1.68395929
60MP0000569_abnormal_digit_pigmentation1.68030655
61MP0003878_abnormal_ear_physiology1.67953537
62MP0005377_hearing/vestibular/ear_phenot1.67953537
63MP0003984_embryonic_growth_retardation1.66656117
64MP0002877_abnormal_melanocyte_morpholog1.66142059
65MP0009703_decreased_birth_body1.65218678
66MP0001849_ear_inflammation1.64205215
67MP0004947_skin_inflammation1.61597446
68MP0002088_abnormal_embryonic_growth/wei1.61048507
69MP0003279_aneurysm1.59765314
70MP0004197_abnormal_fetal_growth/weight/1.57189129
71MP0001958_emphysema1.57007579
72MP0000350_abnormal_cell_proliferation1.56750870
73MP0002396_abnormal_hematopoietic_system1.56236657
74MP0002796_impaired_skin_barrier1.54052760
75MP0003091_abnormal_cell_migration1.52455762
76MP0004233_abnormal_muscle_weight1.52336832
77MP0001293_anophthalmia1.50672395
78MP0003303_peritoneal_inflammation1.50471389
79MP0002405_respiratory_system_inflammati1.48812255
80MP0001697_abnormal_embryo_size1.46605071
81MP0005310_abnormal_salivary_gland1.46106945
82MP0003724_increased_susceptibility_to1.45871541
83MP0010155_abnormal_intestine_physiology1.45644617
84MP0001533_abnormal_skeleton_physiology1.45015041
85MP0002080_prenatal_lethality1.42515169
86MP0009278_abnormal_bone_marrow1.39961673
87MP0004264_abnormal_extraembryonic_tissu1.34582656
88MP0000716_abnormal_immune_system1.32956993
89MP0000428_abnormal_craniofacial_morphol1.32758815
90MP0003448_altered_tumor_morphology1.32232504
91MP0001845_abnormal_inflammatory_respons1.30469363
92MP0005397_hematopoietic_system_phenotyp1.29907790
93MP0001545_abnormal_hematopoietic_system1.29907790
94MP0001299_abnormal_eye_distance/1.29297011
95MP0000579_abnormal_nail_morphology1.27833320
96MP0005058_abnormal_lysosome_morphology1.26993242
97MP0001879_abnormal_lymphatic_vessel1.25633506
98MP0002398_abnormal_bone_marrow1.25602315
99MP0000767_abnormal_smooth_muscle1.25554874
100MP0000858_altered_metastatic_potential1.25380908
101MP0002111_abnormal_tail_morphology1.25222329
102MP0000566_synostosis1.23479982
103MP0005023_abnormal_wound_healing1.22813529
104MP0002933_joint_inflammation1.22074873
105MP0004185_abnormal_adipocyte_glucose1.20329653
106MP0003861_abnormal_nervous_system1.20226892
107MP0004808_abnormal_hematopoietic_stem1.20050471
108MP0001188_hyperpigmentation1.19663021
109MP0006292_abnormal_olfactory_placode1.19281683
110MP0009764_decreased_sensitivity_to1.18907822
111MP0002086_abnormal_extraembryonic_tissu1.17642455
112MP0000432_abnormal_head_morphology1.16734997
113MP0003453_abnormal_keratinocyte_physiol1.15996472
114MP0002998_abnormal_bone_remodeling1.14196508
115MP0005076_abnormal_cell_differentiation1.13837545
116MP0010368_abnormal_lymphatic_system1.13204021
117MP0001286_abnormal_eye_development1.13190112
118MP0006054_spinal_hemorrhage1.11320462
119MP0008469_abnormal_protein_level1.11314419
120MP0002060_abnormal_skin_morphology1.08816699
121MP0002429_abnormal_blood_cell1.08341613
122MP0002009_preneoplasia1.08001210
123MP0000049_abnormal_middle_ear1.07846761
124MP0002089_abnormal_postnatal_growth/wei1.07566899
125MP0004858_abnormal_nervous_system1.05827095
126MP0005503_abnormal_tendon_morphology1.04277661
127MP0001346_abnormal_lacrimal_gland1.03690090
128MP0003045_fibrosis1.03423545
129MP0009333_abnormal_splenocyte_physiolog1.01905990
130MP0009840_abnormal_foam_cell1.01605245
131MP0000689_abnormal_spleen_morphology1.01257690
132MP0001661_extended_life_span1.00846130
133MP0003115_abnormal_respiratory_system1.00373773
134MP0002722_abnormal_immune_system0.98729153
135MP0001243_abnormal_dermal_layer0.98485292
136MP0003828_pulmonary_edema0.96512265
137MP0008007_abnormal_cellular_replicative0.95714054
138MP0008004_abnormal_stomach_pH0.93939390
139MP0000313_abnormal_cell_death0.92209008
140MP0004782_abnormal_surfactant_physiolog0.91912149
141MP0000249_abnormal_blood_vessel0.90849698
142MP0003763_abnormal_thymus_physiology0.90837364
143MP0005390_skeleton_phenotype0.90637124
144MP0000343_altered_response_to0.89695545
145MP0009053_abnormal_anal_canal0.89335011
146MP0003787_abnormal_imprinting0.88685342
147MP0003252_abnormal_bile_duct0.86233559
148MP0000733_abnormal_muscle_development0.85477598
149MP0005501_abnormal_skin_physiology0.84307135
150MP0004272_abnormal_basement_membrane0.83807154
151MP0008770_decreased_survivor_rate0.83273162
152MP0002295_abnormal_pulmonary_circulatio0.82915590
153MP0009697_abnormal_copulation0.82619456
154MP0002928_abnormal_bile_duct0.82541928
155MP0002090_abnormal_vision0.80525109
156MP0002925_abnormal_cardiovascular_devel0.80118637
157MP0001915_intracranial_hemorrhage0.79460623
158MP0003123_paternal_imprinting0.77515202
159MP0003121_genomic_imprinting0.76983035
160MP0003935_abnormal_craniofacial_develop0.76816114
161MP0010630_abnormal_cardiac_muscle0.76506400
162MP0002136_abnormal_kidney_physiology0.73988699
163MP0001485_abnormal_pinna_reflex0.72403896
164MP0001542_abnormal_bone_strength0.71445989
165MP0005395_other_phenotype0.71267855
166MP0000678_abnormal_parathyroid_gland0.71149773
167MP0009763_increased_sensitivity_to0.70642289
168MP0005164_abnormal_response_to0.70595032
169MP0010307_abnormal_tumor_latency0.70396230
170MP0003942_abnormal_urinary_system0.70373278
171MP0004883_abnormal_blood_vessel0.70192816
172MP0003172_abnormal_lysosome_physiology0.69457606
173MP0000465_gastrointestinal_hemorrhage0.69128488
174MP0002163_abnormal_gland_morphology0.69114204
175MP0002081_perinatal_lethality0.68534696
176MP0003075_altered_response_to0.68493164
177MP0009384_cardiac_valve_regurgitation0.66508962
178MP0002233_abnormal_nose_morphology0.65418268
179MP0001177_atelectasis0.63103835
180MP0002092_abnormal_eye_morphology0.62330958
181MP0005621_abnormal_cell_physiology0.60529572
182MP0000490_abnormal_crypts_of0.60295140
183MP0003283_abnormal_digestive_organ0.57160544
184MP0005257_abnormal_intraocular_pressure0.56537509
185MP0002938_white_spotting0.55983941
186MP0001145_abnormal_male_reproductive0.55884931
187MP0003755_abnormal_palate_morphology0.54787281
188MP0002210_abnormal_sex_determination0.54615257
189MP0000266_abnormal_heart_morphology0.54072061
190MP0005647_abnormal_sex_gland0.53977679
191MP0000762_abnormal_tongue_morphology0.53270512

Predicted human phenotypes

RankGene SetZ-score
1Hepatoblastoma (HP:0002884)4.75342748
2Eczematoid dermatitis (HP:0000976)4.24876041
3Recurrent abscess formation (HP:0002722)4.10605766
4Recurrent bacterial skin infections (HP:0005406)4.02441720
5Dysmetric saccades (HP:0000641)3.81510423
6Abnormality of the labia minora (HP:0012880)3.77663219
7Selective tooth agenesis (HP:0001592)3.70441335
8Choanal stenosis (HP:0000452)3.69196606
9Spastic diplegia (HP:0001264)3.68469161
10Nephroblastoma (Wilms tumor) (HP:0002667)3.63938048
11Colon cancer (HP:0003003)3.60089217
12Peritonitis (HP:0002586)3.49112802
13Myositis (HP:0100614)3.44496278
14Interstitial pulmonary disease (HP:0006530)3.42229166
15Embryonal renal neoplasm (HP:0011794)3.41191103
16Osteolytic defects of the phalanges of the hand (HP:0009771)3.22446233
17Osteolytic defects of the hand bones (HP:0009699)3.22446233
18Bilateral microphthalmos (HP:0007633)3.16533764
19Hematochezia (HP:0002573)3.15651377
20Orchitis (HP:0100796)3.13459793
21Recurrent fungal infections (HP:0002841)3.12412222
22Chronic bronchitis (HP:0004469)3.08826939
23Septo-optic dysplasia (HP:0100842)3.08203465
24Cerebral aneurysm (HP:0004944)3.03475403
25Cortical dysplasia (HP:0002539)3.02974587
26Chronic otitis media (HP:0000389)3.02647279
27Bronchomalacia (HP:0002780)3.02463714
28Protrusio acetabuli (HP:0003179)3.01342058
29Elevated erythrocyte sedimentation rate (HP:0003565)3.00433971
30Thrombocytosis (HP:0001894)2.93091789
31Periodontitis (HP:0000704)2.89361381
32Myocardial infarction (HP:0001658)2.86577557
33Recurrent gram-negative bacterial infections (HP:0005420)2.86382428
34Aortic dissection (HP:0002647)2.84604334
35Aortic aneurysm (HP:0004942)2.84031101
36Premature rupture of membranes (HP:0001788)2.83546234
37Recurrent skin infections (HP:0001581)2.83468969
38Optic neuritis (HP:0100653)2.81381596
39Retrobulbar optic neuritis (HP:0100654)2.81381596
40Recurrent viral infections (HP:0004429)2.78302636
41Birth length less than 3rd percentile (HP:0003561)2.77411424
42Systemic lupus erythematosus (HP:0002725)2.75558159
43Skull defect (HP:0001362)2.69149249
44Autoimmune thrombocytopenia (HP:0001973)2.67520805
45Cellulitis (HP:0100658)2.63922771
46Arterial thrombosis (HP:0004420)2.63013807
47Colitis (HP:0002583)2.62761050
48Abnormality of macrophages (HP:0004311)2.62042220
49Pulmonary infiltrates (HP:0002113)2.60604152
50Short hallux (HP:0010109)2.60484681
51Vertebral compression fractures (HP:0002953)2.57318797
52Malignant gastrointestinal tract tumors (HP:0006749)2.56454299
53Gastrointestinal carcinoma (HP:0002672)2.56454299
54Ependymoma (HP:0002888)2.55759439
55Genetic anticipation (HP:0003743)2.55445239
56Abdominal situs inversus (HP:0003363)2.54833754
57Abnormality of abdominal situs (HP:0011620)2.54833754
58Spontaneous hematomas (HP:0007420)2.54013712
59Increased IgE level (HP:0003212)2.53993857
60Mediastinal lymphadenopathy (HP:0100721)2.53190122
61Turricephaly (HP:0000262)2.52298029
62Homocystinuria (HP:0002156)2.52289718
63Abnormality of homocysteine metabolism (HP:0010919)2.52289718
64Absent radius (HP:0003974)2.51577091
65Multiple enchondromatosis (HP:0005701)2.50672303
66Aplasia/Hypoplasia of the sternum (HP:0006714)2.50377761
67Recurrent cutaneous fungal infections (HP:0011370)2.49439631
68Chronic mucocutaneous candidiasis (HP:0002728)2.49439631
69Neoplasm of the adrenal cortex (HP:0100641)2.48868158
70Vasculitis (HP:0002633)2.46228965
71Abnormal delayed hypersensitivity skin test (HP:0002963)2.45369614
72Maternal diabetes (HP:0009800)2.43365841
73Gastrointestinal infarctions (HP:0005244)2.42401567
74Atrophic scars (HP:0001075)2.41886520
75Aplasia/Hypoplasia of the hallux (HP:0008362)2.40391771
76Agammaglobulinemia (HP:0004432)2.39472627
77Gingivitis (HP:0000230)2.36279770
78Chromosomal breakage induced by crosslinking agents (HP:0003221)2.34959782
79Increased nuchal translucency (HP:0010880)2.34374057
80Absent forearm bone (HP:0003953)2.33647681
81Aplasia involving forearm bones (HP:0009822)2.33647681
82Abnormality of the salivary glands (HP:0010286)2.30373750
83Abnormal lung lobation (HP:0002101)2.29797065
84Abnormality of the nasal mucosa (HP:0000433)2.29651148
85Inflammation of the large intestine (HP:0002037)2.29632233
86Cervical subluxation (HP:0003308)2.27359523
87Aplasia involving bones of the extremities (HP:0009825)2.26486225
88Aplasia involving bones of the upper limbs (HP:0009823)2.26486225
89Aplasia of the phalanges of the hand (HP:0009802)2.26486225
90Chromsome breakage (HP:0040012)2.24612795
91Myelomeningocele (HP:0002475)2.22529471
92Spinal cord lesions (HP:0100561)2.21443852
93Syringomyelia (HP:0003396)2.21443852
94Gingival bleeding (HP:0000225)2.20569226
95Esophageal varix (HP:0002040)2.20195434
96Impulsivity (HP:0100710)2.19827933
97Facial cleft (HP:0002006)2.19160736
98Protruding tongue (HP:0010808)2.19001431
99Hyperglycinuria (HP:0003108)2.17121433
100Meningitis (HP:0001287)2.16825031
101Broad thumb (HP:0011304)2.16641950
102Intestinal fistula (HP:0100819)2.16519845
103Urethral obstruction (HP:0000796)2.16086988
104Keratoconjunctivitis (HP:0001096)2.15724358
105Gastrointestinal inflammation (HP:0004386)2.14509551
106Nasal polyposis (HP:0100582)2.13207218
107Cutaneous syndactyly (HP:0012725)2.13146495
108Absent eyebrow (HP:0002223)2.13033416
109Emphysema (HP:0002097)2.12945767
110Osteomyelitis (HP:0002754)2.12904720
111Aqueductal stenosis (HP:0002410)2.12709637
112Absent eyelashes (HP:0000561)2.12353597
113Trigonocephaly (HP:0000243)2.12302384
114Absent frontal sinuses (HP:0002688)2.12041207
115Embryonal neoplasm (HP:0002898)2.11505974
116Nephritis (HP:0000123)2.10544889
117Pustule (HP:0200039)2.10023476
118Dilatation of the ascending aorta (HP:0005111)2.09271316
119Thick nail (HP:0001805)2.09114556
120Stenosis of the external auditory canal (HP:0000402)2.08420276
121Rhabdomyosarcoma (HP:0002859)2.07225962
122Spondylolisthesis (HP:0003302)2.05670494
123Preaxial foot polydactyly (HP:0001841)2.05554543
124Abnormal platelet volume (HP:0011876)2.04786044
125Mitral valve prolapse (HP:0001634)2.03777179
126Hypergammaglobulinemia (HP:0010702)2.03570930
127Biliary tract neoplasm (HP:0100574)2.02476921
128Hemoptysis (HP:0002105)2.02235282
129Eosinophilia (HP:0001880)2.02064028
130Uterine neoplasm (HP:0010784)1.99060974
131Medulloblastoma (HP:0002885)1.98677828
132Abnormality of the septum pellucidum (HP:0007375)1.98185519
133Keratoconjunctivitis sicca (HP:0001097)1.98161349
134Abnormality of proline metabolism (HP:0010907)1.97697840
135Hydroxyprolinuria (HP:0003080)1.97697840
136Leukocytosis (HP:0001974)1.97414790
137Vaginal fistula (HP:0004320)1.96444966
138Rectovaginal fistula (HP:0000143)1.96121040
139Rectal fistula (HP:0100590)1.96121040
140Abnormal number of incisors (HP:0011064)1.95132562
141Carpal bone hypoplasia (HP:0001498)1.94328591
142High anterior hairline (HP:0009890)1.94179356
143Ankle contracture (HP:0006466)1.93906872
144Esophageal atresia (HP:0002032)1.93885343
145Camptodactyly of toe (HP:0001836)1.93880776
146Hyperglycinemia (HP:0002154)1.93838674
147External ophthalmoplegia (HP:0000544)1.93512997
148Epistaxis (HP:0000421)1.92918440
149Increased mean platelet volume (HP:0011877)1.92202661
150Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.90020727
151Vascular tortuosity (HP:0004948)1.88928079
152Alopecia of scalp (HP:0002293)1.88887619
153Abnormality of the lacrimal duct (HP:0011481)1.88481935
154Skin ulcer (HP:0200042)1.87942226
155Recurrent lower respiratory tract infections (HP:0002783)1.87654352
156Arnold-Chiari malformation (HP:0002308)1.86832553
157Flexion contracture of toe (HP:0005830)1.86392728
158Joint contractures involving the joints of the feet (HP:0100492)1.86392728
159Overriding aorta (HP:0002623)1.86016383
160Polycythemia (HP:0001901)1.85803208
161Hypoglycemic seizures (HP:0002173)1.85791012
162Breast aplasia (HP:0100783)1.85079364
163Fatigue (HP:0012378)1.84818014
164Omphalocele (HP:0001539)1.83381629
165Abnormality of the peritoneum (HP:0002585)1.81948773
166Partial duplication of thumb phalanx (HP:0009944)1.81596974
167Petechiae (HP:0000967)1.80303864
168Abnormality of the fingertips (HP:0001211)1.80254098
169Arterial tortuosity (HP:0005116)1.80185628
170Vacuolated lymphocytes (HP:0001922)1.80000544
171Leiomyosarcoma (HP:0100243)1.79853126
172Uterine leiomyosarcoma (HP:0002891)1.79853126
173Clitoromegaly (HP:0000057)1.79290582
174Progressive external ophthalmoplegia (HP:0000590)1.78813402
175Absent septum pellucidum (HP:0001331)1.78500068
176Abnormality of serine family amino acid metabolism (HP:0010894)1.78479571
177Abnormality of glycine metabolism (HP:0010895)1.78479571
178Ectopic kidney (HP:0000086)1.78133784
179Broad metatarsal (HP:0001783)1.77871956
180Abnormality of the pericardium (HP:0001697)1.77688742
181Duplication of thumb phalanx (HP:0009942)1.77632075
182Coronal craniosynostosis (HP:0004440)1.77496966
183Anal stenosis (HP:0002025)1.77394643
184Glomerulonephritis (HP:0000099)1.77019983
185Mucopolysacchariduria (HP:0008155)1.77018435
186Urinary glycosaminoglycan excretion (HP:0003541)1.77018435
187Chest pain (HP:0100749)1.76430141
188Granulocytopenia (HP:0001913)1.76110487
189Shallow orbits (HP:0000586)1.75777891
190Meckel diverticulum (HP:0002245)1.75328735
191Recurrent pneumonia (HP:0006532)1.75081205
192Hypoplasia of the pons (HP:0012110)1.74701908
193Encephalitis (HP:0002383)1.73825656
194Agnosia (HP:0010524)1.73791276
195Cutaneous finger syndactyly (HP:0010554)1.72867028
196Increased neuronal autofluorescent lipopigment (HP:0002074)1.71804342
197Fused cervical vertebrae (HP:0002949)1.71790993
198Generalized hypotonia (HP:0001290)1.71375928

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K144.27846499
2CDC73.50745712
3SMG13.36552073
4TTK3.27577126
5CDK192.92481736
6TAF12.89901102
7TYK22.89291774
8TBK12.72239978
9TSSK62.72068908
10TGFBR22.62163732
11IKBKB2.53983335
12JAK32.50760278
13MKNK12.45132108
14TTN2.28105474
15BUB12.26928603
16VRK22.26191518
17IRAK32.25704614
18ERN12.23837011
19JAK12.21804518
20MAP3K92.18899702
21MAP4K12.18564501
22IRAK42.10654900
23MKNK22.05738727
24KIT2.02521821
25CHUK2.01732134
26EPHB11.93569334
27IKBKE1.90930020
28PASK1.89852190
29FLT31.88259578
30CAMK1G1.86472764
31SRPK11.81677923
32PKN21.81255692
33PLK31.79450516
34LATS21.77578810
35TNIK1.76951721
36CSF1R1.74443933
37FGFR21.74255096
38LATS11.71047193
39MAP3K131.68574651
40NEK91.65526108
41BRD41.60439360
42TRIB31.59842391
43STK38L1.59209351
44ERBB41.58611059
45FGFR41.56705950
46PTK61.53002196
47STK101.49608621
48DYRK31.45958684
49PLK41.45253076
50BLK1.44637546
51NEK21.40365913
52LRRK21.39502215
53MAP2K31.36013652
54FGFR11.34947735
55ZAP701.34127828
56TRPM71.34124946
57DYRK21.32131172
58TAOK31.31671271
59BTK1.29427260
60CHEK21.27105213
61PIM21.26994057
62SIK11.25224039
63EPHA31.24446894
64RIPK41.24413842
65ALK1.21369205
66RPS6KA41.19951951
67ZAK1.19865224
68PAK41.11099031
69PBK1.09592438
70FGFR31.09092034
71PLK11.08592481
72MAP3K101.08087462
73CSK1.07982848
74TEC1.07461584
75MST40.98846807
76BMX0.95448484
77EPHA20.94324177
78CHEK10.93936051
79HCK0.92067762
80ATR0.91847068
81MAP3K30.91639390
82JAK20.91176390
83STK30.90840036
84NTRK10.90129985
85TGFBR10.89525747
86SYK0.88416968
87CDK70.86800109
88PIM10.86451141
89ITK0.84652757
90CDK40.84037506
91CAMK1D0.83607140
92ATM0.83554596
93EEF2K0.83054473
94RIPK10.81155917
95OXSR10.80411707
96NUAK10.80047105
97TYRO30.79817016
98PRKAA20.78283024
99CDK60.76893436
100MTOR0.76408758
101LCK0.75324194
102KDR0.75304205
103TXK0.74202592
104ICK0.74171083
105WEE10.70085296
106DYRK1B0.69698307
107BRSK20.69691880
108CDK20.69525438
109MAPKAPK20.68961989
110CDK10.67413829
111MST1R0.65775250
112TIE10.64913175
113MYLK0.63890189
114LYN0.63221037
115STK40.61593244
116PIK3CG0.60976992
117MET0.58637497
118PRKDC0.56654797
119NLK0.55402239
120DDR20.55109123
121PTK20.55053216
122PAK20.54775938
123CSNK1G10.54376398
124DMPK0.53848434
125NEK10.53404202
126SIK20.53310420
127PNCK0.52904051
128ABL10.52809725
129STK240.52413723
130PDGFRA0.51565975
131AURKB0.51262181
132MOS0.51089664
133CSNK1E0.51004790
134EIF2AK20.50047794
135CLK10.49736496
136PIK3CA0.49553897
137RPS6KA60.48889551
138EPHB20.48527595
139SCYL20.48313782
140GSK3B0.47178382
141MATK0.47062385
142DAPK10.46572766
143CDK120.46147813
144PDGFRB0.45330393
145PRKG20.44915052
146RPS6KA10.44662934
147SIK30.43745404
148DYRK1A0.43718415
149FRK0.43183803
150PKN10.43106082
151IRAK10.43068493
152MAP3K70.42795675
153RPS6KB20.40744321
154RPS6KC10.40450131
155RPS6KL10.40450131
156MAP3K80.39715964
157INSRR0.38600959
158AURKA0.37880526
159MAPK100.37680295
160BRAF0.36873493
161AKT10.35248783
162MAPK140.34515318
163CDK90.33837289
164MAPK90.33727751
165YES10.33107259
166CSNK1D0.31512800
167FGR0.30385678
168NME10.30300508
169PAK10.30210888
170CASK0.29467863
171VRK10.29288047
172CDK11A0.28155335
173MELK0.27485433

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.63508211
2Selenocompound metabolism_Homo sapiens_hsa004503.16316375
3Mismatch repair_Homo sapiens_hsa034303.02080469
4Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.80730238
5NF-kappa B signaling pathway_Homo sapiens_hsa040642.80081622
6Leishmaniasis_Homo sapiens_hsa051402.73069252
7Non-homologous end-joining_Homo sapiens_hsa034502.69665670
8Cysteine and methionine metabolism_Homo sapiens_hsa002702.61673660
9mRNA surveillance pathway_Homo sapiens_hsa030152.54803623
10RNA transport_Homo sapiens_hsa030132.50294402
11Cell cycle_Homo sapiens_hsa041102.49436850
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.41683077
13Spliceosome_Homo sapiens_hsa030402.39778329
14Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.34522061
15Intestinal immune network for IgA production_Homo sapiens_hsa046722.31453003
16Base excision repair_Homo sapiens_hsa034102.28460050
17Osteoclast differentiation_Homo sapiens_hsa043802.22369040
18One carbon pool by folate_Homo sapiens_hsa006702.20407698
19Biosynthesis of amino acids_Homo sapiens_hsa012302.14764406
20Toll-like receptor signaling pathway_Homo sapiens_hsa046202.13252969
21Toxoplasmosis_Homo sapiens_hsa051452.04776161
22NOD-like receptor signaling pathway_Homo sapiens_hsa046212.04456289
23Graft-versus-host disease_Homo sapiens_hsa053321.98782134
24Allograft rejection_Homo sapiens_hsa053301.97248878
25Measles_Homo sapiens_hsa051621.93631324
26Staphylococcus aureus infection_Homo sapiens_hsa051501.93517920
27B cell receptor signaling pathway_Homo sapiens_hsa046621.92467663
28TNF signaling pathway_Homo sapiens_hsa046681.90806506
29Lysine degradation_Homo sapiens_hsa003101.87628082
30Antigen processing and presentation_Homo sapiens_hsa046121.83454577
31Malaria_Homo sapiens_hsa051441.82240920
32Pertussis_Homo sapiens_hsa051331.78591461
33Apoptosis_Homo sapiens_hsa042101.76885233
34Thyroid cancer_Homo sapiens_hsa052161.71953842
35Primary immunodeficiency_Homo sapiens_hsa053401.68794698
36Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.68356383
37Small cell lung cancer_Homo sapiens_hsa052221.67120356
38Viral myocarditis_Homo sapiens_hsa054161.66346595
39RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.65638522
40Tight junction_Homo sapiens_hsa045301.64311802
41Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.61555484
42Basal cell carcinoma_Homo sapiens_hsa052171.56125117
43AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.54647414
44Shigellosis_Homo sapiens_hsa051311.54496977
45Leukocyte transendothelial migration_Homo sapiens_hsa046701.52520889
46Jak-STAT signaling pathway_Homo sapiens_hsa046301.52310852
47Legionellosis_Homo sapiens_hsa051341.51315447
48Hippo signaling pathway_Homo sapiens_hsa043901.51169693
49Influenza A_Homo sapiens_hsa051641.47064882
50Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.44245344
51Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.43117279
52Central carbon metabolism in cancer_Homo sapiens_hsa052301.42659290
53Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.42284177
54Homologous recombination_Homo sapiens_hsa034401.42269299
55Tuberculosis_Homo sapiens_hsa051521.41619167
56Hematopoietic cell lineage_Homo sapiens_hsa046401.40460203
57Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.36470828
58Wnt signaling pathway_Homo sapiens_hsa043101.36071732
59Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.35582912
60Chronic myeloid leukemia_Homo sapiens_hsa052201.34963536
61ECM-receptor interaction_Homo sapiens_hsa045121.31115624
62Vitamin B6 metabolism_Homo sapiens_hsa007501.28684918
63Glycosaminoglycan degradation_Homo sapiens_hsa005311.27701992
64Chemokine signaling pathway_Homo sapiens_hsa040621.27118766
65Basal transcription factors_Homo sapiens_hsa030221.25933604
66Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.25828675
67Herpes simplex infection_Homo sapiens_hsa051681.25804637
68Amoebiasis_Homo sapiens_hsa051461.20356086
69RNA polymerase_Homo sapiens_hsa030201.18951270
70Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.18777926
71Nucleotide excision repair_Homo sapiens_hsa034201.18454627
72Acute myeloid leukemia_Homo sapiens_hsa052211.18190024
73Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.18096039
74Focal adhesion_Homo sapiens_hsa045101.17560305
75Salmonella infection_Homo sapiens_hsa051321.17357787
76Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.16976147
77Carbon metabolism_Homo sapiens_hsa012001.14600843
78Hepatitis B_Homo sapiens_hsa051611.12531458
79Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.10737039
80RNA degradation_Homo sapiens_hsa030181.10676733
81Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.10662331
82Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.10452773
832-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.10217308
84Adherens junction_Homo sapiens_hsa045201.09137128
85Platelet activation_Homo sapiens_hsa046111.08716210
86Other glycan degradation_Homo sapiens_hsa005111.08687222
87Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.08621714
88Autoimmune thyroid disease_Homo sapiens_hsa053201.06498539
89Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.05800035
90Pancreatic cancer_Homo sapiens_hsa052121.05264777
91Complement and coagulation cascades_Homo sapiens_hsa046101.04390612
92Colorectal cancer_Homo sapiens_hsa052101.03164349
93Lysosome_Homo sapiens_hsa041421.00368913
94Hepatitis C_Homo sapiens_hsa051600.98031393
95Proteoglycans in cancer_Homo sapiens_hsa052050.95778812
96Oocyte meiosis_Homo sapiens_hsa041140.95480845
97Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.94324948
98Transcriptional misregulation in cancer_Homo sapiens_hsa052020.93862031
99Fanconi anemia pathway_Homo sapiens_hsa034600.93261663
100Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.88766768
101Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.88269383
102Pyruvate metabolism_Homo sapiens_hsa006200.87211815
103Pentose phosphate pathway_Homo sapiens_hsa000300.86028087
104African trypanosomiasis_Homo sapiens_hsa051430.85631618
105Galactose metabolism_Homo sapiens_hsa000520.83185587
106Steroid biosynthesis_Homo sapiens_hsa001000.80162992
107Regulation of actin cytoskeleton_Homo sapiens_hsa048100.76957754
108T cell receptor signaling pathway_Homo sapiens_hsa046600.76388308
109p53 signaling pathway_Homo sapiens_hsa041150.75552992
110HTLV-I infection_Homo sapiens_hsa051660.75232031
111Caffeine metabolism_Homo sapiens_hsa002320.75103465
112MicroRNAs in cancer_Homo sapiens_hsa052060.74580663
113Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.74051684
114Prolactin signaling pathway_Homo sapiens_hsa049170.73043241
115Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.71557364
116Endometrial cancer_Homo sapiens_hsa052130.71038645
117Adipocytokine signaling pathway_Homo sapiens_hsa049200.70748982
118Arginine and proline metabolism_Homo sapiens_hsa003300.70614233
119Pyrimidine metabolism_Homo sapiens_hsa002400.70351874
120Purine metabolism_Homo sapiens_hsa002300.68947576
121Viral carcinogenesis_Homo sapiens_hsa052030.65776408
122Vitamin digestion and absorption_Homo sapiens_hsa049770.65518099
123Phagosome_Homo sapiens_hsa041450.64186846
124Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.63759222
125Rheumatoid arthritis_Homo sapiens_hsa053230.62153140
126Asthma_Homo sapiens_hsa053100.61264508
127Insulin resistance_Homo sapiens_hsa049310.60131172
128Epstein-Barr virus infection_Homo sapiens_hsa051690.59019216
129Cyanoamino acid metabolism_Homo sapiens_hsa004600.58860408
130Hedgehog signaling pathway_Homo sapiens_hsa043400.58663133
131Neurotrophin signaling pathway_Homo sapiens_hsa047220.57638526
132Pentose and glucuronate interconversions_Homo sapiens_hsa000400.56119687
133Longevity regulating pathway - mammal_Homo sapiens_hsa042110.55487990
134Pathways in cancer_Homo sapiens_hsa052000.54291593
135Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.53882875
136Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.53668871
137Melanoma_Homo sapiens_hsa052180.51661190
138Glucagon signaling pathway_Homo sapiens_hsa049220.50094665
139Thyroid hormone signaling pathway_Homo sapiens_hsa049190.49340428
140Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.49232747
141PI3K-Akt signaling pathway_Homo sapiens_hsa041510.48874554
142Melanogenesis_Homo sapiens_hsa049160.48781886
143HIF-1 signaling pathway_Homo sapiens_hsa040660.47867388
144Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.47291558
145Bladder cancer_Homo sapiens_hsa052190.46562675
146Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.46434811
147Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.46396106
148ABC transporters_Homo sapiens_hsa020100.46137566
149Arginine biosynthesis_Homo sapiens_hsa002200.44896805
150Notch signaling pathway_Homo sapiens_hsa043300.44416835
151Type I diabetes mellitus_Homo sapiens_hsa049400.44157414
152Prostate cancer_Homo sapiens_hsa052150.44087576
153Rap1 signaling pathway_Homo sapiens_hsa040150.43912206
154Renin-angiotensin system_Homo sapiens_hsa046140.42486836
155FoxO signaling pathway_Homo sapiens_hsa040680.42328873
156Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.41947897
157Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.41801957
158Taste transduction_Homo sapiens_hsa047420.41480081
159Insulin signaling pathway_Homo sapiens_hsa049100.41327673
160VEGF signaling pathway_Homo sapiens_hsa043700.41086872
161Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.40740845
162AMPK signaling pathway_Homo sapiens_hsa041520.40570886
163Axon guidance_Homo sapiens_hsa043600.39226100
164Dilated cardiomyopathy_Homo sapiens_hsa054140.38455945
165Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.37209692
166Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.36778382
167Tryptophan metabolism_Homo sapiens_hsa003800.35971570
168TGF-beta signaling pathway_Homo sapiens_hsa043500.35358311
169Fructose and mannose metabolism_Homo sapiens_hsa000510.35061859
170Protein digestion and absorption_Homo sapiens_hsa049740.33838449
171Non-small cell lung cancer_Homo sapiens_hsa052230.33638944
172Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.33581730
173Propanoate metabolism_Homo sapiens_hsa006400.32126948
174Long-term depression_Homo sapiens_hsa047300.31553836
175Nicotine addiction_Homo sapiens_hsa050330.30315679
176Folate biosynthesis_Homo sapiens_hsa007900.29135187
177beta-Alanine metabolism_Homo sapiens_hsa004100.25031421
178Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.24937766
179Proteasome_Homo sapiens_hsa030500.24666396
180ErbB signaling pathway_Homo sapiens_hsa040120.23563299
181Fatty acid biosynthesis_Homo sapiens_hsa000610.22839980
182Starch and sucrose metabolism_Homo sapiens_hsa005000.22423558

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