LRRK2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Mutations in this gene have been associated with Parkinson disease-8. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1detection of molecule of bacterial origin (GO:0032490)6.63390211
2microglial cell activation (GO:0001774)5.68491285
3detection of external biotic stimulus (GO:0098581)5.14129176
4detection of other organism (GO:0098543)4.88848648
5macrophage activation (GO:0042116)4.78960610
6surfactant homeostasis (GO:0043129)4.74053166
7positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)4.73962498
8response to host immune response (GO:0052572)4.64986946
9response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.64986946
10regulation of gamma-delta T cell activation (GO:0046643)4.61178763
11detection of biotic stimulus (GO:0009595)4.48940913
12neutrophil mediated immunity (GO:0002446)4.47746012
13antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.39252427
14response to peptidoglycan (GO:0032494)4.29463692
15response to host (GO:0075136)4.29327432
16response to host defenses (GO:0052200)4.29327432
17response to defenses of other organism involved in symbiotic interaction (GO:0052173)4.29327432
18positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.29155887
19negative regulation of interleukin-12 production (GO:0032695)4.27103411
20negative regulation of lymphocyte mediated immunity (GO:0002707)4.15453472
21regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.13465936
22detection of bacterium (GO:0016045)4.08692381
23myeloid leukocyte mediated immunity (GO:0002444)3.97430634
24chemical homeostasis within a tissue (GO:0048875)3.93379644
25regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.92471145
26B cell receptor signaling pathway (GO:0050853)3.88143889
27antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.86702883
28regulation of B cell receptor signaling pathway (GO:0050855)3.83078946
29production of molecular mediator involved in inflammatory response (GO:0002532)3.81987747
30negative regulation of T cell mediated immunity (GO:0002710)3.76709799
31positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.75529659
32myeloid cell activation involved in immune response (GO:0002275)3.71611014
33positive regulation of Rap GTPase activity (GO:0032854)3.58403600
34antigen processing and presentation via MHC class Ib (GO:0002475)3.58185750
35leukocyte migration involved in inflammatory response (GO:0002523)3.49400162
36negative regulation of leukocyte mediated immunity (GO:0002704)3.47855592
37regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.38617394
38regulation of Rap GTPase activity (GO:0032317)3.37439163
39negative T cell selection (GO:0043383)3.34320583
40positive regulation of macrophage cytokine production (GO:0060907)3.31678246
41antigen processing and presentation of endogenous antigen (GO:0019883)3.26817734
42immunoglobulin mediated immune response (GO:0016064)3.23855609
43negative regulation of B cell mediated immunity (GO:0002713)3.18658580
44negative regulation of immunoglobulin mediated immune response (GO:0002890)3.18658580
45hepatocyte apoptotic process (GO:0097284)3.17900348
46negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.17124539
47negative regulation of B cell proliferation (GO:0030889)3.16229614
48T-helper 1 type immune response (GO:0042088)3.14071887
49antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.13309659
50positive regulation of mast cell activation (GO:0033005)3.13156152
51defense response to protozoan (GO:0042832)3.13110086
52positive T cell selection (GO:0043368)3.12597965
53dendritic cell migration (GO:0036336)3.11486171
54regulation of interferon-alpha production (GO:0032647)3.06952030
55regulation of mast cell degranulation (GO:0043304)3.04756785
56negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.04094762
57type I interferon signaling pathway (GO:0060337)2.97273567
58cellular response to type I interferon (GO:0071357)2.97273567
59protein localization to endosome (GO:0036010)2.97021055
60cellular response to zinc ion (GO:0071294)2.96910484
61regulation of interferon-beta biosynthetic process (GO:0045357)2.96844591
62response to type I interferon (GO:0034340)2.96025196
63regulation of interleukin-6 biosynthetic process (GO:0045408)2.95225130
64regulation of necroptotic process (GO:0060544)2.94211082
65myeloid leukocyte activation (GO:0002274)2.93306620
66regulation of myeloid leukocyte mediated immunity (GO:0002886)2.93275010
67negative regulation of adaptive immune response (GO:0002820)2.92863656
68positive regulation of gamma-delta T cell activation (GO:0046645)2.92771947
69positive regulation of toll-like receptor signaling pathway (GO:0034123)2.91506977
70regulation of mast cell activation (GO:0033003)2.90406402
71regulation of dendritic cell antigen processing and presentation (GO:0002604)2.90276517
72regulation of tolerance induction (GO:0002643)2.89484814
73lipopolysaccharide-mediated signaling pathway (GO:0031663)2.89228657
74activated T cell proliferation (GO:0050798)2.88973877
75response to muramyl dipeptide (GO:0032495)2.88449863
76positive regulation of B cell differentiation (GO:0045579)2.87044522
77regulation of mast cell activation involved in immune response (GO:0033006)2.84413677
78positive regulation of interferon-beta production (GO:0032728)2.81974716
79regulation of macrophage cytokine production (GO:0010935)2.74926635
80stress fiber assembly (GO:0043149)2.71511046
81regulation of ARF protein signal transduction (GO:0032012)2.64706825
82negative regulation of cell killing (GO:0031342)2.63071401
83negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.63071401
84cell adhesion mediated by integrin (GO:0033627)2.54638546
85negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.52271408
86cytoskeletal anchoring at plasma membrane (GO:0007016)2.50763677
87positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.49470305
88regulation of synapse structural plasticity (GO:0051823)2.47793164
89regulation of B cell differentiation (GO:0045577)2.45312357
90prepulse inhibition (GO:0060134)2.44095316
91B cell proliferation (GO:0042100)2.43642861
92apoptotic cell clearance (GO:0043277)2.42441359
93G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.40857426
94negative regulation of synaptic transmission, GABAergic (GO:0032229)2.40294046
95regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.40064811
96macrophage activation involved in immune response (GO:0002281)2.38843676
97growth hormone receptor signaling pathway (GO:0060396)2.36262716
98regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.34307661
99mature B cell differentiation (GO:0002335)2.33773770
100response to interleukin-15 (GO:0070672)2.32918191
101cortical actin cytoskeleton organization (GO:0030866)2.30243928
102synaptic vesicle maturation (GO:0016188)2.29455915
103vascular endothelial growth factor signaling pathway (GO:0038084)2.28538806
104nerve growth factor signaling pathway (GO:0038180)2.28390005
105neutrophil activation (GO:0042119)2.28070524
106Fc-gamma receptor signaling pathway involved in phagocytosis (GO:0038096)2.27148467
107immune response-regulating cell surface receptor signaling pathway involved in phagocytosis (GO:00022.27148467
108Fc-gamma receptor signaling pathway (GO:0038094)2.27148467
109vocalization behavior (GO:0071625)2.26685550
110phosphate ion transmembrane transport (GO:0035435)2.26313926
111cellular extravasation (GO:0045123)2.25714361
112Fc receptor mediated stimulatory signaling pathway (GO:0002431)2.25669627
113glomerular visceral epithelial cell development (GO:0072015)2.24515399
114phosphate ion transport (GO:0006817)2.24248258
115germinal center formation (GO:0002467)2.23337691
116regulation of interleukin-12 biosynthetic process (GO:0045075)2.21907734
117membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.21239126
118positive thymic T cell selection (GO:0045059)2.20642735
119substrate-dependent cell migration (GO:0006929)2.20461266
120JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.18837204
121establishment of nucleus localization (GO:0040023)2.18756596
122activation of protein kinase A activity (GO:0034199)2.18364932
123regulation of beta-amyloid formation (GO:1902003)2.18200499
124positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.18006260
125activation of JUN kinase activity (GO:0007257)2.17700114
126positive regulation of cellular amide metabolic process (GO:0034250)2.16867470
127adenosine receptor signaling pathway (GO:0001973)2.16808099
128I-kappaB phosphorylation (GO:0007252)2.16494599
129cellular potassium ion homeostasis (GO:0030007)2.16175719
130potassium ion import (GO:0010107)2.15772509
131neutrophil activation involved in immune response (GO:0002283)2.15292725
132synaptic vesicle docking involved in exocytosis (GO:0016081)2.14300941
133sodium ion export (GO:0071436)2.14270297
134granulocyte activation (GO:0036230)2.13799580
135negative regulation of vascular permeability (GO:0043116)2.13681823
136positive regulation by organism of defense response of other organism involved in symbiotic interact2.13104469
137modulation by symbiont of host immune response (GO:0052553)2.13104469
138positive regulation by symbiont of host defense response (GO:0052509)2.13104469
139modulation by symbiont of host defense response (GO:0052031)2.13104469
140modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.13104469
141modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.13104469
142regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.12753458
143regulation of gamma-delta T cell differentiation (GO:0045586)2.12605479
144negative thymic T cell selection (GO:0045060)2.12558858
145positive regulation of interferon-alpha production (GO:0032727)2.11814676
146* locomotory exploration behavior (GO:0035641)2.11119069
147interferon-gamma-mediated signaling pathway (GO:0060333)2.09916397
148cortical cytoskeleton organization (GO:0030865)2.08501002
149positive regulation of fibroblast migration (GO:0010763)2.08461870
150positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.08284194
151cellular response to interleukin-15 (GO:0071350)2.07580430
152establishment of endothelial barrier (GO:0061028)2.07395474
153negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.06403423
154regulation of leukocyte degranulation (GO:0043300)2.05659460
155leukocyte aggregation (GO:0070486)2.05643929
156regulation of glutamate receptor signaling pathway (GO:1900449)2.05442708
157plasma membrane repair (GO:0001778)2.05199044
158respiratory burst (GO:0045730)2.04853596
159regulation of regulated secretory pathway (GO:1903305)2.04714284
160negative regulation of fatty acid transport (GO:2000192)2.04387503
161hypotonic response (GO:0006971)2.04211141
162cAMP catabolic process (GO:0006198)2.04075929
163glomerular epithelial cell development (GO:0072310)2.03879421
164cAMP biosynthetic process (GO:0006171)2.01773198

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human3.28898309
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.19584398
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.62617159
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.43314199
5SCL_19346495_ChIP-Seq_HPC-7_Human2.40748628
6SMAD_19615063_ChIP-ChIP_OVARY_Human2.36753935
7* SPI1_23547873_ChIP-Seq_NB4_Human2.36439215
8IRF8_21731497_ChIP-ChIP_J774_Mouse2.31920045
9IKZF1_21737484_ChIP-ChIP_HCT116_Human2.10621617
10IRF8_27001747_Chip-Seq_BMDM_Mouse2.08835905
11VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.98554407
12SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.93228580
13MYB_26560356_Chip-Seq_TH1_Human1.86656333
14CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.84120025
15STAT4_19710469_ChIP-ChIP_TH1__Mouse1.80780470
16EZH2_22144423_ChIP-Seq_EOC_Human1.75947737
17DROSHA_22980978_ChIP-Seq_HELA_Human1.73724632
18GATA3_27048872_Chip-Seq_THYMUS_Human1.73234190
19KDM2B_26808549_Chip-Seq_SUP-B15_Human1.70888771
20* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.70500276
21RUNX_20019798_ChIP-Seq_JUKART_Human1.70375114
22MAF_26560356_Chip-Seq_TH1_Human1.68216542
23TRIM28_21343339_ChIP-Seq_HEK293_Human1.67430587
24Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.66305841
25EGR1_19374776_ChIP-ChIP_THP-1_Human1.64427092
26GATA1_22025678_ChIP-Seq_K562_Human1.62088431
27PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.61772149
28RUNX1_22412390_ChIP-Seq_EML_Mouse1.61648408
29RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.60065567
30GATA1_19941827_ChIP-Seq_MEL_Mouse1.57722476
31PU_27001747_Chip-Seq_BMDM_Mouse1.57604559
32ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.56089842
33RARB_27405468_Chip-Seq_BRAIN_Mouse1.55617033
34SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.55459540
35RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.51968549
36GATA2_21666600_ChIP-Seq_HMVEC_Human1.50955193
37STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.49646343
38SPI1_23127762_ChIP-Seq_K562_Human1.49592920
39IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.48945937
40SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.48040454
41STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.47864040
42NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.47668273
43MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.44416332
44BP1_19119308_ChIP-ChIP_Hs578T_Human1.43958004
45GATA3_26560356_Chip-Seq_TH2_Human1.43256755
46* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.42395972
47ZNF217_24962896_ChIP-Seq_MCF-7_Human1.41750847
48ESR1_20079471_ChIP-ChIP_T-47D_Human1.40984724
49CDX2_19796622_ChIP-Seq_MESCs_Mouse1.39760710
50TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.39276604
51* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.38547501
52VDR_24787735_ChIP-Seq_THP-1_Human1.38527113
53TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.38250516
54TP53_16413492_ChIP-PET_HCT116_Human1.38217254
55NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.38030037
56GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.37266032
57VDR_21846776_ChIP-Seq_THP-1_Human1.36968071
58* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.35325189
59UTX_26944678_Chip-Seq_JUKART_Human1.35030670
60AHR_22903824_ChIP-Seq_MCF-7_Human1.33955567
61GBX2_23144817_ChIP-Seq_PC3_Human1.33153997
62SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.32670028
63* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.32655349
64RXR_22108803_ChIP-Seq_LS180_Human1.32573378
65E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.29493259
66EZH2_18974828_ChIP-Seq_MESCs_Mouse1.29236080
67RNF2_18974828_ChIP-Seq_MESCs_Mouse1.29236080
68GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.26593056
69CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.25432848
70* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.23607585
71RARG_19884340_ChIP-ChIP_MEFs_Mouse1.23173394
72WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.22900572
73RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.22095671
74PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.21279657
75ARNT_22903824_ChIP-Seq_MCF-7_Human1.20905129
76MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.19933100
77KDM2B_26808549_Chip-Seq_DND41_Human1.19826623
78FOXO3_23340844_ChIP-Seq_DLD1_Human1.19319638
79IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.19100307
80JARID2_20064375_ChIP-Seq_MESCs_Mouse1.18683670
81EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.18475205
82FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.18078844
83* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.17906682
84BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.17731737
85FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.17212000
86GATA2_22383799_ChIP-Seq_G1ME_Mouse1.16147415
87BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.15572019
88GATA1_19941826_ChIP-Seq_K562_Human1.15411681
89EP300_21415370_ChIP-Seq_HL-1_Mouse1.14383840
90GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13978199
91GATA2_19941826_ChIP-Seq_K562_Human1.13669416
92THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.11877441
93MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.11111000
94NRF2_20460467_ChIP-Seq_MEFs_Mouse1.10872913
95NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.10872913
96LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.10498775
97KDM2B_26808549_Chip-Seq_K562_Human1.10288711
98WT1_25993318_ChIP-Seq_PODOCYTE_Human1.08911681
99AR_21572438_ChIP-Seq_LNCaP_Human1.08842749
100CJUN_26792858_Chip-Seq_BT549_Human1.06868669
101TCF7_22412390_ChIP-Seq_EML_Mouse1.04792081
102TP53_18474530_ChIP-ChIP_U2OS_Human1.04079833
103CTNNB1_20460455_ChIP-Seq_HCT116_Human1.02656552
104GATA1_19941827_ChIP-Seq_MEL86_Mouse1.02051905
105JARID2_20075857_ChIP-Seq_MESCs_Mouse1.01167882
106VDR_24763502_ChIP-Seq_THP-1_Human1.00652860
107LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.00092522
108NR3C1_23031785_ChIP-Seq_PC12_Mouse0.97605491
109SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.97490019
110ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.97300606
111STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.96690142
112MAF_26560356_Chip-Seq_TH2_Human0.96574976
113ESR2_21235772_ChIP-Seq_MCF-7_Human0.96201813
114PIAS1_25552417_ChIP-Seq_VCAP_Human0.95590928
115PPAR_26484153_Chip-Seq_NCI-H1993_Human0.95195871
116SMAD4_21799915_ChIP-Seq_A2780_Human0.94210459
117CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94091420
118SMRT_27268052_Chip-Seq_Bcells_Human0.94025707
119PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93478928
120* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.92679444
121BRD4_27068464_Chip-Seq_AML-cells_Mouse0.92335942
122SOX2_21211035_ChIP-Seq_LN229_Gbm0.91915019
123SMAD3_21741376_ChIP-Seq_HESCs_Human0.91754337
124DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.91494039
125AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.89829499
126SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.89702974
127KDM2B_26808549_Chip-Seq_JURKAT_Human0.89588636
128TBX20_22080862_ChIP-Seq_HEART_Mouse0.89586976
129TBX20_22328084_ChIP-Seq_HEART_Mouse0.89586976
130NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.89045701
131FOXA2_19822575_ChIP-Seq_HepG2_Human0.88850515
132MYB_26560356_Chip-Seq_TH2_Human0.88838926
133KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.88567476
134CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.88490743
135GATA1_22383799_ChIP-Seq_G1ME_Mouse0.88318321
136KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.88100166
137TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.87665281
138MYC_22102868_ChIP-Seq_BL_Human0.86501773
139KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.86359192
140CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.83735544
141VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.82238673
142FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.80956434
143STAT6_21828071_ChIP-Seq_BEAS2B_Human0.73388442
144GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.72782387
145SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.71873608
146PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.69937902
147SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.69631852
148CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.69245142
149* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.66149185
150RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.65505664
151SALL4_18804426_ChIP-ChIP_XEN_Mouse0.65300590
152FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.64728019
153SALL4_22934838_ChIP-ChIP_CD34+_Human0.64704034
154PRDM14_20953172_ChIP-Seq_ESCs_Human0.64339118

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001958_emphysema4.00055264
2MP0003303_peritoneal_inflammation3.37213789
3MP0000569_abnormal_digit_pigmentation3.30764007
4MP0001835_abnormal_antigen_presentation3.14198695
5MP0001790_abnormal_immune_system2.87732596
6MP0005387_immune_system_phenotype2.87732596
7MP0004859_abnormal_synaptic_plasticity2.82938798
8MP0003300_gastrointestinal_ulcer2.54504054
9MP0005451_abnormal_body_composition2.46494497
10MP0002822_catalepsy2.41480025
11MP0004381_abnormal_hair_follicle2.23909848
12MP0003091_abnormal_cell_migration2.19634127
13MP0004510_myositis2.16091916
14MP0001800_abnormal_humoral_immune2.13996629
15MP0006082_CNS_inflammation2.13021143
16MP0000685_abnormal_immune_system2.04557072
17MP0005167_abnormal_blood-brain_barrier2.00274293
18MP0003045_fibrosis2.00218687
19MP0003763_abnormal_thymus_physiology1.99336243
20MP0003183_abnormal_peptide_metabolism1.98792702
21MP0004782_abnormal_surfactant_physiolog1.94965328
22MP0005000_abnormal_immune_tolerance1.91555073
23MP0003787_abnormal_imprinting1.89952885
24MP0002452_abnormal_antigen_presenting1.88319872
25MP0002138_abnormal_hepatobiliary_system1.85191712
26MP0010234_abnormal_vibrissa_follicle1.82930622
27MP0010352_gastrointestinal_tract_polyps1.77064927
28* MP0008260_abnormal_autophagy1.74084925
29MP0003436_decreased_susceptibility_to1.72541968
30MP0002132_abnormal_respiratory_system1.70398183
31MP0003656_abnormal_erythrocyte_physiolo1.68592021
32MP0003279_aneurysm1.64987831
33MP0008438_abnormal_cutaneous_collagen1.63898291
34MP0003566_abnormal_cell_adhesion1.63123782
35MP0003075_altered_response_to1.59837567
36MP0001177_atelectasis1.59163004
37MP0002133_abnormal_respiratory_system1.58985023
38MP0005388_respiratory_system_phenotype1.58985023
39MP0008961_abnormal_basal_metabolism1.56543617
40MP0000015_abnormal_ear_pigmentation1.55146852
41MP0002419_abnormal_innate_immunity1.54442880
42MP0003690_abnormal_glial_cell1.51178303
43MP0002722_abnormal_immune_system1.47339859
44MP0002723_abnormal_immune_serum1.45260770
45MP0005623_abnormal_meninges_morphology1.45026761
46MP0003866_abnormal_defecation1.44735294
47MP0000465_gastrointestinal_hemorrhage1.43652639
48MP0002166_altered_tumor_susceptibility1.43588192
49MP0002420_abnormal_adaptive_immunity1.43543837
50MP0000858_altered_metastatic_potential1.42684128
51MP0003635_abnormal_synaptic_transmissio1.42516899
52MP0001819_abnormal_immune_cell1.39849144
53MP0005058_abnormal_lysosome_morphology1.39847207
54MP0003221_abnormal_cardiomyocyte_apopto1.37679043
55MP0003705_abnormal_hypodermis_morpholog1.36549480
56MP0002277_abnormal_respiratory_mucosa1.35488247
57MP0009780_abnormal_chondrocyte_physiolo1.34688330
58MP0002168_other_aberrant_phenotype1.34148173
59MP0002396_abnormal_hematopoietic_system1.32811692
60MP0000703_abnormal_thymus_morphology1.31843792
61* MP0002429_abnormal_blood_cell1.31534972
62MP0001879_abnormal_lymphatic_vessel1.31194016
63MP0005397_hematopoietic_system_phenotyp1.31089892
64MP0001545_abnormal_hematopoietic_system1.31089892
65MP0005174_abnormal_tail_pigmentation1.30001060
66MP0001851_eye_inflammation1.29218085
67MP0005166_decreased_susceptibility_to1.28538045
68MP0008004_abnormal_stomach_pH1.27817555
69MP0005075_abnormal_melanosome_morpholog1.26574214
70MP0009278_abnormal_bone_marrow1.25845102
71MP0002006_tumorigenesis1.22153898
72MP0002295_abnormal_pulmonary_circulatio1.21179577
73MP0009046_muscle_twitch1.20631465
74MP0002148_abnormal_hypersensitivity_rea1.19774353
75MP0008469_abnormal_protein_level1.18191309
76MP0009785_altered_susceptibility_to1.14951982
77* MP0009745_abnormal_behavioral_response1.13889344
78MP0005025_abnormal_response_to1.13339262
79MP0002063_abnormal_learning/memory/cond1.12441143
80* MP0002136_abnormal_kidney_physiology1.12008022
81MP0002332_abnormal_exercise_endurance1.10395551
82MP0002405_respiratory_system_inflammati1.10167140
83MP0005671_abnormal_response_to1.08370967
84MP0002928_abnormal_bile_duct1.07346582
85MP0001765_abnormal_ion_homeostasis1.06470027
86MP0003172_abnormal_lysosome_physiology1.05917253
87MP0003724_increased_susceptibility_to1.03852987
88MP0003828_pulmonary_edema1.03589382
89MP0005464_abnormal_platelet_physiology1.02235800
90MP0001873_stomach_inflammation1.01891260
91MP0004808_abnormal_hematopoietic_stem1.01461232
92* MP0000716_abnormal_immune_system1.01291435
93MP0008057_abnormal_DNA_replication1.00973972
94* MP0008874_decreased_physiological_sensi1.00876871
95MP0004883_abnormal_blood_vessel0.99168547
96MP0002064_seizures0.98737591
97MP0004947_skin_inflammation0.98432372
98MP0009764_decreased_sensitivity_to0.98094756
99* MP0001845_abnormal_inflammatory_respons0.97224430
100MP0000767_abnormal_smooth_muscle0.97140718
101MP0004484_altered_response_of0.94887503
102MP0000343_altered_response_to0.94652341
103MP0009333_abnormal_splenocyte_physiolog0.93074466
104MP0002998_abnormal_bone_remodeling0.92861535
105MP0002398_abnormal_bone_marrow0.92712310
106MP0001853_heart_inflammation0.92380600
107MP0003191_abnormal_cellular_cholesterol0.91667386
108MP0005310_abnormal_salivary_gland0.91086632
109MP0000604_amyloidosis0.90833812
110MP0001533_abnormal_skeleton_physiology0.90673869
111MP0001501_abnormal_sleep_pattern0.89091923
112MP0010368_abnormal_lymphatic_system0.89022802
113MP0000249_abnormal_blood_vessel0.88129715
114MP0005164_abnormal_response_to0.85013621
115MP0003329_amyloid_beta_deposits0.82887784
116MP0004272_abnormal_basement_membrane0.82066557
117MP0005023_abnormal_wound_healing0.81769748
118MP0000689_abnormal_spleen_morphology0.81572341
119MP0005275_abnormal_skin_tensile0.81165927
120MP0003633_abnormal_nervous_system0.81109146
121MP0001968_abnormal_touch/_nociception0.80559229
122MP0001756_abnormal_urination0.80384854
123MP0000013_abnormal_adipose_tissue0.80015935
124MP0008569_lethality_at_weaning0.79720354
125MP0003448_altered_tumor_morphology0.79331964
126MP0010155_abnormal_intestine_physiology0.78101554
127MP0004858_abnormal_nervous_system0.77409950
128MP0008877_abnormal_DNA_methylation0.77272042
129MP0009763_increased_sensitivity_to0.77203326
130MP0004130_abnormal_muscle_cell0.77128972
131MP0000371_diluted_coat_color0.76006968
132MP0002009_preneoplasia0.74073661
133MP0005376_homeostasis/metabolism_phenot0.74073117
134MP0006054_spinal_hemorrhage0.69837014
135MP0009765_abnormal_xenobiotic_induced0.63740824
136MP0001663_abnormal_digestive_system0.61094773
137MP0005390_skeleton_phenotype0.56104086
138MP0003252_abnormal_bile_duct0.53761696
139MP0005408_hypopigmentation0.52035668

Predicted human phenotypes

RankGene SetZ-score
1Retrobulbar optic neuritis (HP:0100654)5.64984859
2Optic neuritis (HP:0100653)5.64984859
3Orchitis (HP:0100796)5.62854692
4Myositis (HP:0100614)5.53213482
5Interstitial pulmonary disease (HP:0006530)4.86666476
6Gastrointestinal infarctions (HP:0005244)4.79198746
7T lymphocytopenia (HP:0005403)4.42913036
8Keratoconjunctivitis sicca (HP:0001097)4.28304467
9Abnormality of T cell number (HP:0011839)4.21631517
10Elevated erythrocyte sedimentation rate (HP:0003565)3.99742503
11Peritonitis (HP:0002586)3.99092923
12Keratoconjunctivitis (HP:0001096)3.93484368
13Gastrointestinal stroma tumor (HP:0100723)3.91716071
14Stomatitis (HP:0010280)3.89293262
15Agammaglobulinemia (HP:0004432)3.82432631
16Gingival bleeding (HP:0000225)3.64554229
17Hematochezia (HP:0002573)3.59616056
18Arterial thrombosis (HP:0004420)3.56970688
19Colitis (HP:0002583)3.56088035
20Encephalitis (HP:0002383)3.45862428
21Cellulitis (HP:0100658)3.45301876
22Obstructive lung disease (HP:0006536)3.39394234
23Chronic obstructive pulmonary disease (HP:0006510)3.39394234
24Recurrent abscess formation (HP:0002722)3.38239339
25Eczematoid dermatitis (HP:0000976)3.28844181
26Cerebral aneurysm (HP:0004944)3.26970014
27Chest pain (HP:0100749)3.26181736
28Hemoptysis (HP:0002105)3.23202869
29Hyperactive renin-angiotensin system (HP:0000841)3.21474065
30Urticaria (HP:0001025)3.13325189
31Recurrent bacterial skin infections (HP:0005406)3.12667446
32Mitral stenosis (HP:0001718)3.06404658
33Leukocytosis (HP:0001974)3.02483537
34Abnormality of T cells (HP:0002843)2.85574009
35Emphysema (HP:0002097)2.82363083
36Pulmonary embolism (HP:0002204)2.80603769
37Inflammation of the large intestine (HP:0002037)2.80596674
38Absent frontal sinuses (HP:0002688)2.77160739
39Epistaxis (HP:0000421)2.72011485
40Hypokalemic alkalosis (HP:0001949)2.68247922
41Anorexia (HP:0002039)2.66168798
42Verrucae (HP:0200043)2.65455835
43Papilloma (HP:0012740)2.65455835
44Prolonged bleeding time (HP:0003010)2.65046357
45Gastrointestinal inflammation (HP:0004386)2.63705219
46Restrictive lung disease (HP:0002091)2.61118044
47Abnormality of the peritoneum (HP:0002585)2.58624265
48Ulnar bowing (HP:0003031)2.58255692
49Gangrene (HP:0100758)2.57718447
50Mediastinal lymphadenopathy (HP:0100721)2.57642114
51Episodic fever (HP:0001954)2.57308830
52Amyloidosis (HP:0011034)2.53595583
53Papilledema (HP:0001085)2.53261633
54Slow saccadic eye movements (HP:0000514)2.51460001
55Recurrent gram-negative bacterial infections (HP:0005420)2.51123031
56* Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.45158138
57Vertebral arch anomaly (HP:0008438)2.43573921
58Gout (HP:0001997)2.40537681
59Abnormality of chloride homeostasis (HP:0011422)2.39515225
60Increased IgE level (HP:0003212)2.39215466
61Eosinophilia (HP:0001880)2.38318503
62Metabolic alkalosis (HP:0200114)2.38256599
63Recurrent bronchitis (HP:0002837)2.37724580
64Aortic aneurysm (HP:0004942)2.36598074
65Osteolytic defects of the phalanges of the hand (HP:0009771)2.35484957
66Osteolytic defects of the hand bones (HP:0009699)2.35484957
67Increased circulating renin level (HP:0000848)2.34587640
68Granulocytopenia (HP:0001913)2.33062422
69Abnormality of the endocardium (HP:0004306)2.33025231
70Osteomyelitis (HP:0002754)2.30886942
71Dilatation of the ascending aorta (HP:0005111)2.30536068
72Abnormal delayed hypersensitivity skin test (HP:0002963)2.29714639
73Acute hepatic failure (HP:0006554)2.27593845
74Focal motor seizures (HP:0011153)2.23750864
75Viral hepatitis (HP:0006562)2.22504758
76Abnormality of the pleura (HP:0002103)2.22503817
77Hypochromic microcytic anemia (HP:0004840)2.20759048
78Chronic otitis media (HP:0000389)2.19259854
79Recurrent fungal infections (HP:0002841)2.19076193
80Focal seizures (HP:0007359)2.17340384
81Recurrent viral infections (HP:0004429)2.17286115
82Spontaneous hematomas (HP:0007420)2.17220110
83Chronic mucocutaneous candidiasis (HP:0002728)2.16685892
84Recurrent cutaneous fungal infections (HP:0011370)2.16685892
85Neoplasm of the tracheobronchial system (HP:0100552)2.13070066
86Abnormality of macrophages (HP:0004311)2.12414505
87Recurrent skin infections (HP:0001581)2.11326493
88Vertigo (HP:0002321)2.10105879
89Sepsis (HP:0100806)2.09561924
90Vasculitis (HP:0002633)2.09488217
91IgA deficiency (HP:0002720)2.08895765
92Glomerulopathy (HP:0100820)2.07667551
93Lymphopenia (HP:0001888)2.07612633
94Hypochromic anemia (HP:0001931)2.07014992
95Keratitis (HP:0000491)2.06430983
96Gingivitis (HP:0000230)2.05194235
97Renal salt wasting (HP:0000127)2.02245200
98Recurrent sinusitis (HP:0011108)2.01937711
99Broad metatarsal (HP:0001783)2.01531442
100Abnormality of the fingertips (HP:0001211)2.01509579
101Abnormality of eosinophils (HP:0001879)2.00592496
102Thrombophlebitis (HP:0004418)2.00503904
103Microcytic anemia (HP:0001935)1.98100664
104Autoimmune thrombocytopenia (HP:0001973)1.95975944
105Tubulointerstitial fibrosis (HP:0005576)1.95278404
106Pustule (HP:0200039)1.95206415
107Abnormality of cells of the lymphoid lineage (HP:0012140)1.94542102
108Mitral valve prolapse (HP:0001634)1.93114693
109Dysmetric saccades (HP:0000641)1.92890770
110Acne (HP:0001061)1.92362953
111Camptodactyly of toe (HP:0001836)1.91667408
112Arterial tortuosity (HP:0005116)1.91321088
113Action tremor (HP:0002345)1.90905003
114Cheilitis (HP:0100825)1.89816731
115Difficulty running (HP:0009046)1.89786649
116Aqueductal stenosis (HP:0002410)1.88917633
117Shallow orbits (HP:0000586)1.88619207
118Myokymia (HP:0002411)1.88274421
119Abnormality of renin-angiotensin system (HP:0000847)1.88145103
120Long toe (HP:0010511)1.88046422
121Autoimmune hemolytic anemia (HP:0001890)1.87637960
122Increased IgM level (HP:0003496)1.87599688
123Vascular tortuosity (HP:0004948)1.87377106
124Chronic sinusitis (HP:0011109)1.86212466
125IgM deficiency (HP:0002850)1.86020658
126Abnormality of renal excretion (HP:0011036)1.85789216
127Papillary thyroid carcinoma (HP:0002895)1.85697858
128Hemangiomatosis (HP:0007461)1.85564050
129Increased density of long bones (HP:0006392)1.85237157
130Macroorchidism (HP:0000053)1.85180355
131Hypomagnesemia (HP:0002917)1.84976942
132Skin ulcer (HP:0200042)1.84583427
133Persistence of primary teeth (HP:0006335)1.84354708
134Polycythemia (HP:0001901)1.84242100
135Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.83678904
136Abnormality of T cell physiology (HP:0011840)1.83370082
137Meningitis (HP:0001287)1.82953308
138Stomach cancer (HP:0012126)1.82432078
139Amaurosis fugax (HP:0100576)1.82393980
140Fatigue (HP:0012378)1.81736986
141Abnormality of the vasculature of the conjunctiva (HP:0008054)1.81392996
142Pulmonary infiltrates (HP:0002113)1.81278059
143Visceral angiomatosis (HP:0100761)1.80445209
144Distal lower limb amyotrophy (HP:0008944)1.80230507
145Lower limb amyotrophy (HP:0007210)1.80056465
146Subacute progressive viral hepatitis (HP:0006572)1.79732698
147Alveolar cell carcinoma (HP:0006519)1.78720315
148Xerostomia (HP:0000217)1.78171194
149Polyuria (HP:0000103)1.77665196
150Upper limb amyotrophy (HP:0009129)1.77205066
151Distal upper limb amyotrophy (HP:0007149)1.77205066
152Atonic seizures (HP:0010819)1.75567884
153Hypergammaglobulinemia (HP:0010702)1.74610221
154Abnormal urine output (HP:0012590)1.74475875
155Hyperaldosteronism (HP:0000859)1.73880545
156Recurrent pneumonia (HP:0006532)1.73629639
157Periodontitis (HP:0000704)1.72824484
158Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.72626180
159Facial diplegia (HP:0001349)1.72210957
160Panhypogammaglobulinemia (HP:0003139)1.71654409
161Paresthesia (HP:0003401)1.71632520
162Tachypnea (HP:0002789)1.71501971
163Conjunctival telangiectasia (HP:0000524)1.71358074
164Hemiplegia (HP:0002301)1.70243533
165Syringomyelia (HP:0003396)1.69129387
166Spinal cord lesions (HP:0100561)1.69129387
167Tetany (HP:0001281)1.68806210
168Bowed forearm bones (HP:0003956)1.68221253

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.07270090
2IRAK43.15631440
3MAP3K133.01100278
4MAP2K32.82733848
5EPHA42.76683034
6MAP4K12.71427462
7MAP3K92.64765801
8TTN2.58486092
9RIPK11.97518867
10TRIB31.85086999
11MAP3K141.84560733
12JAK11.84039303
13IRAK11.83562645
14TXK1.81854808
15DAPK21.73833425
16SIK21.70190504
17GRK61.68691712
18TAOK31.65094531
19KSR21.58068587
20YES11.56460778
21JAK21.56457293
22IRAK21.54926779
23FES1.54877140
24CAMK1G1.52616934
25PIK3CG1.51383870
26CAMK1D1.45896703
27NTRK31.45442376
28SGK31.44887053
29PRPF4B1.43055846
30MAP3K11.39455983
31BMPR21.39287467
32CSF1R1.37394357
33MAP3K61.37026401
34CAMKK11.36492571
35WNK11.35168980
36PTK2B1.34198778
37MAP3K31.33206007
38PRKCH1.31470231
39FGFR31.30006208
40CSK1.28824657
41TYK21.27614185
42FRK1.27594483
43FGFR21.24849160
44ERN11.24844506
45OXSR11.24503102
46EPHB11.22645268
47STK101.21557570
48FGR1.20491647
49HCK1.20113448
50CAMKK21.14035419
51WNK41.12460880
52SYK1.11510002
53SGK21.11075196
54NTRK11.09391249
55TEC1.09040001
56TGFBR21.07489061
57PDK10.99935485
58BLK0.99226101
59MARK30.98716738
60LCK0.98343915
61PDGFRA0.97224008
62PDPK10.94733217
63NLK0.92911356
64EPHA30.92428045
65PTK60.91002581
66RAF10.88770891
67JAK30.87314604
68PRKCQ0.85866546
69MAP3K110.85690516
70STK110.85236615
71SGK4940.85116434
72SGK2230.85116434
73MAP2K40.84270754
74PDGFRB0.83973905
75GRK50.82013919
76DMPK0.81944290
77MAP3K20.81684586
78BTK0.80672671
79BMX0.78540327
80CDC42BPA0.77470933
81STK40.77341385
82MAP3K50.75786787
83FYN0.75592224
84MATK0.75417130
85WNK30.75149057
86DAPK10.74823650
87MAP3K70.74550965
88SGK10.73315554
89SIK10.73062504
90KSR10.71771591
91TBK10.70582899
92SIK30.68975022
93TAOK10.68318842
94TRPM70.68070115
95ALK0.67943889
96PIM10.66571684
97* LRRK20.66477616
98RET0.65355060
99DDR20.65283637
100MAP3K120.63892037
101ERBB20.63567161
102PAK60.62936473
103CDK50.62912921
104KIT0.61742483
105TNK20.61609709
106EGFR0.61138767
107GRK10.61105509
108ZAP700.58649664
109IKBKB0.58354502
110SCYL20.57402589
111LMTK20.57209981
112PRKD20.56963412
113INSR0.55358808
114DYRK1B0.55137253
115MINK10.54230069
116TIE10.54141374
117MAP3K100.52799241
118CDK190.52731778
119PRKD10.52640127
120LYN0.51926715
121MAP2K10.51913999
122MARK20.51449153
123ITK0.51376422
124IKBKE0.50878830
125FGFR40.50817309
126ACVR1B0.50724244
127PKN20.50461049
128DYRK1A0.49518468
129DYRK30.49433553
130IRAK30.48162894
131STK380.45446798
132NEK90.44318139
133MAPK70.42563393
134HIPK20.42206485
135MAPK120.42107682
136CAMK40.41169992
137MAP2K60.40983104
138PAK30.38749305
139NEK60.34752464

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051502.58038023
2B cell receptor signaling pathway_Homo sapiens_hsa046622.47402303
3Measles_Homo sapiens_hsa051621.81171506
4Graft-versus-host disease_Homo sapiens_hsa053321.73391443
5Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.71351453
6Legionellosis_Homo sapiens_hsa051341.68138167
7Allograft rejection_Homo sapiens_hsa053301.67893490
8Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.67751610
9Autoimmune thyroid disease_Homo sapiens_hsa053201.61801354
10Olfactory transduction_Homo sapiens_hsa047401.54652069
11Gastric acid secretion_Homo sapiens_hsa049711.54002401
12Long-term potentiation_Homo sapiens_hsa047201.53656907
13Leishmaniasis_Homo sapiens_hsa051401.51107822
14Influenza A_Homo sapiens_hsa051641.50495165
15Acute myeloid leukemia_Homo sapiens_hsa052211.49208349
16Osteoclast differentiation_Homo sapiens_hsa043801.46680173
17Jak-STAT signaling pathway_Homo sapiens_hsa046301.45095092
18Salivary secretion_Homo sapiens_hsa049701.42039721
19RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.41418173
20Leukocyte transendothelial migration_Homo sapiens_hsa046701.38091093
21Chemokine signaling pathway_Homo sapiens_hsa040621.33335888
22Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.33188244
23Renin secretion_Homo sapiens_hsa049241.32696359
24Morphine addiction_Homo sapiens_hsa050321.32531192
25Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.29890922
26Hepatitis B_Homo sapiens_hsa051611.29737706
27Circadian entrainment_Homo sapiens_hsa047131.28375909
28Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.28304285
29Glioma_Homo sapiens_hsa052141.24454378
30AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.24160580
31Platelet activation_Homo sapiens_hsa046111.23693483
32Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.21844050
33Tuberculosis_Homo sapiens_hsa051521.20701079
34Phosphatidylinositol signaling system_Homo sapiens_hsa040701.19966485
35Prolactin signaling pathway_Homo sapiens_hsa049171.19158159
36Aldosterone synthesis and secretion_Homo sapiens_hsa049251.18368716
37Type I diabetes mellitus_Homo sapiens_hsa049401.17291679
38Antigen processing and presentation_Homo sapiens_hsa046121.16910360
39Hepatitis C_Homo sapiens_hsa051601.15160162
40Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.14927035
41Synaptic vesicle cycle_Homo sapiens_hsa047211.13641680
42Oxytocin signaling pathway_Homo sapiens_hsa049211.12310226
43Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.10686812
44Primary immunodeficiency_Homo sapiens_hsa053401.10377080
45Herpes simplex infection_Homo sapiens_hsa051681.09770481
46Focal adhesion_Homo sapiens_hsa045101.07097244
47Dorso-ventral axis formation_Homo sapiens_hsa043201.06585783
48Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.05881201
49Viral myocarditis_Homo sapiens_hsa054161.05453721
50Glutamatergic synapse_Homo sapiens_hsa047241.05392923
51Hematopoietic cell lineage_Homo sapiens_hsa046401.05367743
52African trypanosomiasis_Homo sapiens_hsa051431.04447401
53Apoptosis_Homo sapiens_hsa042101.04337668
54FoxO signaling pathway_Homo sapiens_hsa040681.04062893
55Amphetamine addiction_Homo sapiens_hsa050311.03674185
56Cholinergic synapse_Homo sapiens_hsa047251.03640596
57NF-kappa B signaling pathway_Homo sapiens_hsa040641.03284461
58Neurotrophin signaling pathway_Homo sapiens_hsa047221.02569761
59GnRH signaling pathway_Homo sapiens_hsa049121.02105378
60Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.02103627
61Proteoglycans in cancer_Homo sapiens_hsa052050.98742351
62Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.98095712
63Phospholipase D signaling pathway_Homo sapiens_hsa040720.97065293
64Salmonella infection_Homo sapiens_hsa051320.95602740
65Dilated cardiomyopathy_Homo sapiens_hsa054140.94923906
66Rap1 signaling pathway_Homo sapiens_hsa040150.94885540
67Toll-like receptor signaling pathway_Homo sapiens_hsa046200.94643580
68Non-small cell lung cancer_Homo sapiens_hsa052230.94525691
69Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.94057284
70VEGF signaling pathway_Homo sapiens_hsa043700.93652970
71Type II diabetes mellitus_Homo sapiens_hsa049300.92889092
72Estrogen signaling pathway_Homo sapiens_hsa049150.92694943
73Amoebiasis_Homo sapiens_hsa051460.92447368
74Endometrial cancer_Homo sapiens_hsa052130.92376871
75Toxoplasmosis_Homo sapiens_hsa051450.92329223
76Dopaminergic synapse_Homo sapiens_hsa047280.92149705
77Shigellosis_Homo sapiens_hsa051310.91354773
78Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.91042342
79Intestinal immune network for IgA production_Homo sapiens_hsa046720.90904241
80Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.90152619
81Malaria_Homo sapiens_hsa051440.89981329
82TNF signaling pathway_Homo sapiens_hsa046680.88931990
83Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.88679143
84Regulation of actin cytoskeleton_Homo sapiens_hsa048100.88013316
85GABAergic synapse_Homo sapiens_hsa047270.87964631
86Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.87439287
87Gap junction_Homo sapiens_hsa045400.86344491
88Collecting duct acid secretion_Homo sapiens_hsa049660.86181365
89Long-term depression_Homo sapiens_hsa047300.86137304
90Pancreatic cancer_Homo sapiens_hsa052120.86050275
91Chronic myeloid leukemia_Homo sapiens_hsa052200.85679270
92Calcium signaling pathway_Homo sapiens_hsa040200.85384903
93Inositol phosphate metabolism_Homo sapiens_hsa005620.83779504
94Pertussis_Homo sapiens_hsa051330.83079360
95cGMP-PKG signaling pathway_Homo sapiens_hsa040220.82920316
96MAPK signaling pathway_Homo sapiens_hsa040100.82634606
97cAMP signaling pathway_Homo sapiens_hsa040240.81687031
98Phagosome_Homo sapiens_hsa041450.80530769
99Cocaine addiction_Homo sapiens_hsa050300.80200361
100Nicotine addiction_Homo sapiens_hsa050330.79239152
101Rheumatoid arthritis_Homo sapiens_hsa053230.78776285
102mTOR signaling pathway_Homo sapiens_hsa041500.78233793
103Thyroid hormone synthesis_Homo sapiens_hsa049180.77378352
104Asthma_Homo sapiens_hsa053100.75122478
105ECM-receptor interaction_Homo sapiens_hsa045120.75065903
106Endocytosis_Homo sapiens_hsa041440.74809724
107Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.73833847
108ErbB signaling pathway_Homo sapiens_hsa040120.73482661
109Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.72802493
110Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.72625956
111Notch signaling pathway_Homo sapiens_hsa043300.72234429
112Lysosome_Homo sapiens_hsa041420.72214284
113Small cell lung cancer_Homo sapiens_hsa052220.72018503
114Adherens junction_Homo sapiens_hsa045200.70901213
115Choline metabolism in cancer_Homo sapiens_hsa052310.69825188
116HIF-1 signaling pathway_Homo sapiens_hsa040660.69379113
117Thyroid hormone signaling pathway_Homo sapiens_hsa049190.69307139
118Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.69002387
119Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.68549375
120Insulin secretion_Homo sapiens_hsa049110.67564299
121T cell receptor signaling pathway_Homo sapiens_hsa046600.67536308
122Vascular smooth muscle contraction_Homo sapiens_hsa042700.67160386
123Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.64081404
124Renal cell carcinoma_Homo sapiens_hsa052110.63970126
125Adipocytokine signaling pathway_Homo sapiens_hsa049200.62948647
126Carbohydrate digestion and absorption_Homo sapiens_hsa049730.62588385
127Insulin resistance_Homo sapiens_hsa049310.62509751
128Sphingolipid signaling pathway_Homo sapiens_hsa040710.62279315
129NOD-like receptor signaling pathway_Homo sapiens_hsa046210.62243307
130SNARE interactions in vesicular transport_Homo sapiens_hsa041300.61746521
131Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.60284680
132Prostate cancer_Homo sapiens_hsa052150.59460255
133Taste transduction_Homo sapiens_hsa047420.58801012
134Viral carcinogenesis_Homo sapiens_hsa052030.56361490
135Colorectal cancer_Homo sapiens_hsa052100.52623407
136Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.46067225
137Epstein-Barr virus infection_Homo sapiens_hsa051690.44566667
138Longevity regulating pathway - mammal_Homo sapiens_hsa042110.43687538
139Regulation of autophagy_Homo sapiens_hsa041400.43578040

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