LRRN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)7.75072805
2central nervous system myelination (GO:0022010)7.75072805
3regulation of gene silencing by RNA (GO:0060966)5.75857503
4regulation of posttranscriptional gene silencing (GO:0060147)5.75857503
5regulation of gene silencing by miRNA (GO:0060964)5.75857503
6paraxial mesoderm development (GO:0048339)5.44838636
7fatty acid elongation (GO:0030497)5.06577343
8myelination (GO:0042552)4.88032086
9axon ensheathment (GO:0008366)4.86372124
10ensheathment of neurons (GO:0007272)4.86372124
11pre-miRNA processing (GO:0031054)4.69058568
12presynaptic membrane organization (GO:0097090)4.37740748
13neuron cell-cell adhesion (GO:0007158)4.26579231
14negative regulation of neurotransmitter secretion (GO:0046929)4.18020066
15long-chain fatty acid biosynthetic process (GO:0042759)4.16128311
16apical protein localization (GO:0045176)4.15037058
17presynaptic membrane assembly (GO:0097105)4.11053670
18lateral sprouting from an epithelium (GO:0060601)4.08510178
19negative regulation of neurotransmitter transport (GO:0051589)4.06325284
20positive regulation of oligodendrocyte differentiation (GO:0048714)4.03846386
21establishment of integrated proviral latency (GO:0075713)3.94934022
22convergent extension (GO:0060026)3.88422869
23regulation of cell fate specification (GO:0042659)3.86887986
24planar cell polarity pathway involved in neural tube closure (GO:0090179)3.85777943
25establishment of mitochondrion localization (GO:0051654)3.80584626
26heterochromatin organization (GO:0070828)3.78051056
27negative regulation of translation, ncRNA-mediated (GO:0040033)3.76211125
28regulation of translation, ncRNA-mediated (GO:0045974)3.76211125
29negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.76211125
30oligodendrocyte differentiation (GO:0048709)3.69127092
31asymmetric protein localization (GO:0008105)3.68704420
32photoreceptor cell differentiation (GO:0046530)3.68206334
33eye photoreceptor cell differentiation (GO:0001754)3.68206334
34myelin maintenance (GO:0043217)3.65100856
35neuronal action potential propagation (GO:0019227)3.65025177
36L-serine metabolic process (GO:0006563)3.64502913
37regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.60225045
38lung-associated mesenchyme development (GO:0060484)3.47465102
39positive regulation of SMAD protein import into nucleus (GO:0060391)3.42046839
40negative regulation of protein localization to cell surface (GO:2000009)3.40175960
41notochord development (GO:0030903)3.38152016
42L-amino acid import (GO:0043092)3.35107907
43pyrimidine nucleobase catabolic process (GO:0006208)3.33336910
44G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.32263167
45protein localization to kinetochore (GO:0034501)3.31306108
46peptidyl-tyrosine autophosphorylation (GO:0038083)3.30136149
47transmission of nerve impulse (GO:0019226)3.29471818
48synaptic vesicle maturation (GO:0016188)3.29132883
49response to methylmercury (GO:0051597)3.23333909
50neuron recognition (GO:0008038)3.21719524
51postsynaptic membrane organization (GO:0001941)3.17920151
52generation of neurons (GO:0048699)3.16895300
53positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.12810714
54adult walking behavior (GO:0007628)3.08426202
55neuronal stem cell maintenance (GO:0097150)3.08188924
56protein complex localization (GO:0031503)3.07210669
57dendritic spine morphogenesis (GO:0060997)3.02186115
58axonal fasciculation (GO:0007413)3.01688474
59chromatin remodeling at centromere (GO:0031055)3.00264807
60regulation of synaptic vesicle exocytosis (GO:2000300)3.00249629
61negative regulation of axonogenesis (GO:0050771)2.98552242
62cerebral cortex radially oriented cell migration (GO:0021799)2.97834990
63dendrite morphogenesis (GO:0048813)2.97663089
64DNA unwinding involved in DNA replication (GO:0006268)2.97616232
65regulation of gene silencing (GO:0060968)2.96490508
66regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.96352748
67regulation of short-term neuronal synaptic plasticity (GO:0048172)2.95871916
68cholesterol biosynthetic process (GO:0006695)2.95575419
69amino acid import (GO:0043090)2.95322579
70outer ear morphogenesis (GO:0042473)2.94242959
71dorsal/ventral axis specification (GO:0009950)2.93503438
72nerve growth factor signaling pathway (GO:0038180)2.93456095
73regulation of histone H3-K9 methylation (GO:0051570)2.93174782
74mesenchymal to epithelial transition (GO:0060231)2.91610354
75protein palmitoylation (GO:0018345)2.90813641
76nucleosome disassembly (GO:0006337)2.89653512
77protein-DNA complex disassembly (GO:0032986)2.89653512
78somatic stem cell division (GO:0048103)2.89642772
79regulation of collateral sprouting (GO:0048670)2.88763704
80kidney morphogenesis (GO:0060993)2.87055442
81cell fate commitment involved in formation of primary germ layer (GO:0060795)2.86871788
82mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.86868789
83establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.85321433
84magnesium ion transport (GO:0015693)2.82207156
85establishment of viral latency (GO:0019043)2.80386980
86mating behavior (GO:0007617)2.79180822
87ionotropic glutamate receptor signaling pathway (GO:0035235)2.79071598
88regulation of non-canonical Wnt signaling pathway (GO:2000050)2.78654288
89neuronal ion channel clustering (GO:0045161)2.78473225
90glycerophospholipid catabolic process (GO:0046475)2.78172478
91positive regulation of catenin import into nucleus (GO:0035413)2.76477135
92ATP-dependent chromatin remodeling (GO:0043044)2.76340997
93long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.76185245
94negative regulation of histone methylation (GO:0031061)2.75798981
95substantia nigra development (GO:0021762)2.75765522
96regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.75515561
97locomotory exploration behavior (GO:0035641)2.74981026
98CENP-A containing nucleosome assembly (GO:0034080)2.74961675
99cell surface receptor signaling pathway involved in heart development (GO:0061311)2.74788620
100negative regulation of gene silencing (GO:0060969)2.72171092
101axon development (GO:0061564)2.72066240
102detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.71050383
103detection of temperature stimulus involved in sensory perception (GO:0050961)2.71050383
104response to lipoprotein particle (GO:0055094)2.70686308
105synaptic vesicle exocytosis (GO:0016079)2.70182926
106regulation of stem cell maintenance (GO:2000036)2.69839372
107astrocyte development (GO:0014002)2.69779008
108negative regulation of axon extension (GO:0030517)2.69701550
109regulation of cell fate commitment (GO:0010453)2.69537092
110cerebellar granule cell differentiation (GO:0021707)2.69339108
111DNA replication-independent nucleosome organization (GO:0034724)2.69068764
112DNA replication-independent nucleosome assembly (GO:0006336)2.69068764
113Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.68867882
114positive regulation of glial cell differentiation (GO:0045687)2.68165947
115digestive tract morphogenesis (GO:0048546)2.67966795
116vocalization behavior (GO:0071625)2.67020651
117regulation of helicase activity (GO:0051095)2.62481599
118non-canonical Wnt signaling pathway (GO:0035567)2.62176886
119sterol biosynthetic process (GO:0016126)2.61659236
120negative regulation of cell fate specification (GO:0009996)2.61457184
121regulation of development, heterochronic (GO:0040034)2.61177239
122negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.61083791
123DNA damage response, detection of DNA damage (GO:0042769)2.60531334
124peripheral nervous system axon ensheathment (GO:0032292)2.59331080
125myelination in peripheral nervous system (GO:0022011)2.59331080
126regulation of establishment of planar polarity (GO:0090175)2.58396990
127synaptic transmission, glutamatergic (GO:0035249)2.58322555
128glutamate secretion (GO:0014047)2.58013663
129histone exchange (GO:0043486)2.57097782
130anterior/posterior axis specification, embryo (GO:0008595)2.57029930
131limb bud formation (GO:0060174)2.55309124
132creatine metabolic process (GO:0006600)2.54227124
133protein localization to chromosome, centromeric region (GO:0071459)2.54138894
134neural tube closure (GO:0001843)2.53902338
135innervation (GO:0060384)2.53638929
136regulation of oligodendrocyte differentiation (GO:0048713)2.52620435
137tube closure (GO:0060606)2.52225441
138negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.51618162
139histone arginine methylation (GO:0034969)2.50784313
140positive regulation of cell cycle G2/M phase transition (GO:1902751)2.50440444
141positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)2.50440444
142regulation of amyloid precursor protein catabolic process (GO:1902991)2.49944475
143organelle transport along microtubule (GO:0072384)2.49156001
144regulation of SMAD protein import into nucleus (GO:0060390)2.49060295
145long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.48927275
146cell migration in hindbrain (GO:0021535)2.48707998
147neuron projection extension involved in neuron projection guidance (GO:1902284)2.48558080
148axon extension involved in axon guidance (GO:0048846)2.48558080
149positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.48220654
150neurofilament cytoskeleton organization (GO:0060052)2.47741503
151regulation of neuronal synaptic plasticity (GO:0048168)2.47178830
152organ growth (GO:0035265)2.47167452
153glycosylceramide metabolic process (GO:0006677)2.47118394
154glutamate receptor signaling pathway (GO:0007215)2.47088161
155cranial nerve development (GO:0021545)2.46823733
156astrocyte differentiation (GO:0048708)2.46120971
157response to redox state (GO:0051775)2.45387127
158inner ear receptor cell development (GO:0060119)2.45357892
159midbrain development (GO:0030901)2.45200416
160regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.44943177
161mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.44912295
162somatic stem cell maintenance (GO:0035019)2.44671531
163somite development (GO:0061053)2.44087763
164positive regulation of potassium ion transport (GO:0043268)2.44079071
165spinal cord motor neuron differentiation (GO:0021522)2.43985333
166negative regulation of cell fate commitment (GO:0010454)2.43779872
167detection of temperature stimulus (GO:0016048)2.43751753
168layer formation in cerebral cortex (GO:0021819)2.43482333
169negative regulation of fibroblast apoptotic process (GO:2000270)2.42872031
170neuron-neuron synaptic transmission (GO:0007270)2.42649990
171isoprenoid biosynthetic process (GO:0008299)2.42527130
172post-anal tail morphogenesis (GO:0036342)2.42460706
173mitotic metaphase plate congression (GO:0007080)2.41825898
174spinal cord development (GO:0021510)2.41622809
175DNA topological change (GO:0006265)2.41026770
176protein localization to synapse (GO:0035418)2.40917233
177regulation of synaptic vesicle transport (GO:1902803)2.39602218
178regulation of chromatin silencing (GO:0031935)2.39258701
179establishment of monopolar cell polarity (GO:0061162)2.38493332
180establishment or maintenance of monopolar cell polarity (GO:0061339)2.38493332
181regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.38375413
182neuron remodeling (GO:0016322)2.38024895
183cellular response to cholesterol (GO:0071397)2.37879150
184pituitary gland development (GO:0021983)2.37796259
185regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.37683614
186positive regulation of synapse assembly (GO:0051965)2.36144215
187stem cell division (GO:0017145)2.35747294
188membrane assembly (GO:0071709)2.35629787
189gamma-aminobutyric acid signaling pathway (GO:0007214)2.35558039
190negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.35364780
191import into cell (GO:0098657)2.35181030
192negative regulation of JUN kinase activity (GO:0043508)2.34498677
193negative regulation of synaptic transmission, GABAergic (GO:0032229)2.34202314

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.17139268
2RBPJ_22232070_ChIP-Seq_NCS_Mouse4.02630834
3E2F7_22180533_ChIP-Seq_HELA_Human3.76338381
4GBX2_23144817_ChIP-Seq_PC3_Human3.70935709
5KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.03508045
6KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.03508045
7KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.03508045
8NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.92149509
9SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.76702103
10* POU5F1_16153702_ChIP-ChIP_HESCs_Human2.76052735
11HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.75432605
12* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.72183455
13SALL1_21062744_ChIP-ChIP_HESCs_Human2.70035862
14FOXM1_23109430_ChIP-Seq_U2OS_Human2.69737214
15JARID2_20064375_ChIP-Seq_MESCs_Mouse2.69589537
16EZH2_18974828_ChIP-Seq_MESCs_Mouse2.47067003
17RNF2_18974828_ChIP-Seq_MESCs_Mouse2.47067003
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.45907969
19SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.37703097
20* SOX2_16153702_ChIP-ChIP_HESCs_Human2.34480408
21POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.33237264
22* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.31280419
23JARID2_20075857_ChIP-Seq_MESCs_Mouse2.30272364
24* EED_16625203_ChIP-ChIP_MESCs_Mouse2.27126439
25* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.26483947
26* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.23699344
27* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.22692417
28EZH2_27294783_Chip-Seq_ESCs_Mouse2.18174425
29TAF15_26573619_Chip-Seq_HEK293_Human2.13726781
30* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.12464543
31* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.12066197
32SOX2_18555785_ChIP-Seq_MESCs_Mouse2.04806387
33E2F4_17652178_ChIP-ChIP_JURKAT_Human2.01187637
34* RNF2_27304074_Chip-Seq_ESCs_Mouse2.00630741
35NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.98043181
36ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.97202706
37ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.96864397
38TCF3_18692474_ChIP-Seq_MEFs_Mouse1.94019989
39KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.91664919
40* NANOG_16153702_ChIP-ChIP_HESCs_Human1.90294439
41OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.89386461
42SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.87728882
43* REST_21632747_ChIP-Seq_MESCs_Mouse1.83360840
44DROSHA_22980978_ChIP-Seq_HELA_Human1.78546783
45MYC_18555785_ChIP-Seq_MESCs_Mouse1.75408017
46TCF3_18692474_ChIP-Seq_MESCs_Mouse1.74684099
47AR_21572438_ChIP-Seq_LNCaP_Human1.71696975
48PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.69496911
49SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.67944492
50ZFP57_27257070_Chip-Seq_ESCs_Mouse1.67394284
51* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.65726013
52POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.64829790
53CBX2_27304074_Chip-Seq_ESCs_Mouse1.64284143
54* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.63635719
55HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.63420253
56RARB_27405468_Chip-Seq_BRAIN_Mouse1.62159365
57RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.61480811
58GATA1_26923725_Chip-Seq_HPCs_Mouse1.57229151
59FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.55578919
60CTBP2_25329375_ChIP-Seq_LNCAP_Human1.54675697
61TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.54369779
62GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.54083381
63MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.53505453
64SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.53290154
65TP63_19390658_ChIP-ChIP_HaCaT_Human1.51297790
66EWS_26573619_Chip-Seq_HEK293_Human1.50719966
67SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.49532246
68REST_18959480_ChIP-ChIP_MESCs_Mouse1.49026851
69CTBP1_25329375_ChIP-Seq_LNCAP_Human1.48841509
70E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.47480813
71PIAS1_25552417_ChIP-Seq_VCAP_Human1.47163020
72ZFP281_18757296_ChIP-ChIP_E14_Mouse1.46601885
73TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.46509888
74POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.46458258
75TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.46458258
76CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.45553548
77NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.45412559
78VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.45404012
79CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.45106674
80* SMAD3_21741376_ChIP-Seq_EPCs_Human1.43393126
81TBX3_20139965_ChIP-Seq_MESCs_Mouse1.43280569
82TBX3_20139965_ChIP-Seq_ESCs_Mouse1.43045754
83POU3F2_20337985_ChIP-ChIP_501MEL_Human1.41949662
84CDX2_19796622_ChIP-Seq_MESCs_Mouse1.39144177
85SMAD4_21799915_ChIP-Seq_A2780_Human1.39101372
86AR_21909140_ChIP-Seq_LNCAP_Human1.35860872
87IGF1R_20145208_ChIP-Seq_DFB_Human1.35750302
88BMI1_23680149_ChIP-Seq_NPCS_Mouse1.35588011
89ZNF274_21170338_ChIP-Seq_K562_Hela1.35583279
90MYC_19079543_ChIP-ChIP_MESCs_Mouse1.33460995
91STAT3_23295773_ChIP-Seq_U87_Human1.33338391
92CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.33184366
93* P300_19829295_ChIP-Seq_ESCs_Human1.31974815
94POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.31804049
95TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.30452161
96ISL1_27105846_Chip-Seq_CPCs_Mouse1.30158575
97ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.29742713
98TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.29714615
99* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29713047
100TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29185269
101NR3C1_23031785_ChIP-Seq_PC12_Mouse1.27868380
102WT1_19549856_ChIP-ChIP_CCG9911_Human1.27726015
103VDR_22108803_ChIP-Seq_LS180_Human1.25725985
104MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.22137842
105AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.21576344
106CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.19696532
107RING1B_27294783_Chip-Seq_ESCs_Mouse1.19595576
108SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.19472886
109NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.18901062
110WT1_25993318_ChIP-Seq_PODOCYTE_Human1.18891676
111ARNT_22903824_ChIP-Seq_MCF-7_Human1.17489725
112TOP2B_26459242_ChIP-Seq_MCF-7_Human1.17482821
113POU5F1_16518401_ChIP-PET_MESCs_Mouse1.17029782
114* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.16342737
115SOX9_26525672_Chip-Seq_HEART_Mouse1.15842853
116OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.14998668
117RING1B_27294783_Chip-Seq_NPCs_Mouse1.14957969
118ERG_21242973_ChIP-ChIP_JURKAT_Human1.13577189
119NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.13323701
120ZNF217_24962896_ChIP-Seq_MCF-7_Human1.13100807
121* ER_23166858_ChIP-Seq_MCF-7_Human1.13008625
122NANOG_21062744_ChIP-ChIP_HESCs_Human1.12629978
123RNF2_27304074_Chip-Seq_NSC_Mouse1.12595424
124MYC_19030024_ChIP-ChIP_MESCs_Mouse1.12230830
125AHR_22903824_ChIP-Seq_MCF-7_Human1.11332442
126* SOX2_21211035_ChIP-Seq_LN229_Gbm1.11273063
127NANOG_18555785_ChIP-Seq_MESCs_Mouse1.10874554
128PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.09783132
129KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.09570301
130FUS_26573619_Chip-Seq_HEK293_Human1.08809074
131MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.08006620
132KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.06621355
133YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.06449226
134E2F1_21310950_ChIP-Seq_MCF-7_Human1.05272110
135* TCF4_23295773_ChIP-Seq_U87_Human1.04185838
136LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02655246
137ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.01957125
138EP300_21415370_ChIP-Seq_HL-1_Mouse1.01280293
139ZFP281_27345836_Chip-Seq_ESCs_Mouse1.00955943
140SOX2_18692474_ChIP-Seq_MESCs_Mouse1.00784850
141TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.00616554
142P53_22127205_ChIP-Seq_FIBROBLAST_Human0.99747632
143YAP1_20516196_ChIP-Seq_MESCs_Mouse0.98418768
144NR3C1_21868756_ChIP-Seq_MCF10A_Human0.98399059
145SOX2_18692474_ChIP-Seq_MEFs_Mouse0.97466985
146MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.97284622
147RUNX2_22187159_ChIP-Seq_PCA_Human0.96665259
148MYCN_18555785_ChIP-Seq_MESCs_Mouse0.95652271
149UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.94843887
150AR_19668381_ChIP-Seq_PC3_Human0.93960715
151NANOG_18555785_Chip-Seq_ESCs_Mouse0.93849781
152TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.93696868
153PRDM14_20953172_ChIP-Seq_ESCs_Human0.93191740
154GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92165104
155* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.91405666
156* SMAD3_21741376_ChIP-Seq_ESCs_Human0.90193644
157* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.89933934
158* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.89556828
159* AR_25329375_ChIP-Seq_VCAP_Human0.89031873
160NRF2_20460467_ChIP-Seq_MEFs_Mouse0.88934326
161NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.88934326
162TAL1_26923725_Chip-Seq_HPCs_Mouse0.88091027
163SMAD4_21741376_ChIP-Seq_EPCs_Human0.87855093
164MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.86129927
165CMYC_18555785_Chip-Seq_ESCs_Mouse0.84516221
166TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.82446785

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004270_analgesia4.42079392
2MP0003880_abnormal_central_pattern3.92828110
3MP0000920_abnormal_myelination3.49372960
4MP0004859_abnormal_synaptic_plasticity3.42177855
5MP0010030_abnormal_orbit_morphology2.77118574
6MP0003890_abnormal_embryonic-extraembry2.67364714
7MP0006292_abnormal_olfactory_placode2.66233792
8MP0003635_abnormal_synaptic_transmissio2.61860647
9MP0003941_abnormal_skin_development2.57872096
10MP0002272_abnormal_nervous_system2.47991138
11MP0002734_abnormal_mechanical_nocicepti2.46863201
12MP0000778_abnormal_nervous_system2.45438249
13MP0000566_synostosis2.44384979
14MP0002254_reproductive_system_inflammat2.36423959
15MP0001293_anophthalmia2.34529048
16MP0002064_seizures2.32324215
17MP0003329_amyloid_beta_deposits2.30266969
18MP0000537_abnormal_urethra_morphology2.29642533
19MP0001486_abnormal_startle_reflex2.27425214
20MP0004885_abnormal_endolymph2.22616100
21MP0005423_abnormal_somatic_nervous2.11658811
22MP0004133_heterotaxia2.07998208
23MP0003634_abnormal_glial_cell2.06984859
24MP0009745_abnormal_behavioral_response2.06337167
25MP0003119_abnormal_digestive_system2.01414331
26MP0002735_abnormal_chemical_nociception2.01041540
27MP0002063_abnormal_learning/memory/cond1.98104673
28MP0000955_abnormal_spinal_cord1.97609435
29MP0002697_abnormal_eye_size1.95594200
30MP0009672_abnormal_birth_weight1.95554565
31MP0001968_abnormal_touch/_nociception1.92583689
32MP0009046_muscle_twitch1.90958877
33MP0001529_abnormal_vocalization1.89358379
34MP0004142_abnormal_muscle_tone1.86366033
35MP0003693_abnormal_embryo_hatching1.83826653
36MP0004742_abnormal_vestibular_system1.82706751
37MP0002572_abnormal_emotion/affect_behav1.81970717
38MP0002733_abnormal_thermal_nociception1.79524935
39MP0000049_abnormal_middle_ear1.77852229
40MP0003690_abnormal_glial_cell1.77843928
41MP0005645_abnormal_hypothalamus_physiol1.77836337
42MP0003121_genomic_imprinting1.76855339
43MP0002067_abnormal_sensory_capabilities1.74816188
44MP0001970_abnormal_pain_threshold1.74806727
45MP0005171_absent_coat_pigmentation1.74286408
46MP0002736_abnormal_nociception_after1.72728397
47MP0003567_abnormal_fetal_cardiomyocyte1.71756408
48MP0001485_abnormal_pinna_reflex1.70398874
49MP0002184_abnormal_innervation1.69124380
50MP0009780_abnormal_chondrocyte_physiolo1.67349079
51MP0005377_hearing/vestibular/ear_phenot1.65447650
52MP0003878_abnormal_ear_physiology1.65447650
53MP0001299_abnormal_eye_distance/1.65082320
54MP0004957_abnormal_blastocyst_morpholog1.64338553
55MP0002233_abnormal_nose_morphology1.64121148
56MP0005394_taste/olfaction_phenotype1.63756271
57MP0005499_abnormal_olfactory_system1.63756271
58MP0008877_abnormal_DNA_methylation1.62233298
59MP0008932_abnormal_embryonic_tissue1.60607157
60MP0001286_abnormal_eye_development1.60089487
61MP0002882_abnormal_neuron_morphology1.57983440
62MP0001188_hyperpigmentation1.57882233
63MP0000428_abnormal_craniofacial_morphol1.57272799
64MP0004043_abnormal_pH_regulation1.55752019
65MP0001905_abnormal_dopamine_level1.54993249
66MP0000579_abnormal_nail_morphology1.53531655
67MP0001440_abnormal_grooming_behavior1.51324675
68MP0004145_abnormal_muscle_electrophysio1.50516528
69MP0004858_abnormal_nervous_system1.49249926
70MP0003950_abnormal_plasma_membrane1.48071712
71MP0002229_neurodegeneration1.47090671
72MP0008569_lethality_at_weaning1.45281691
73MP0008789_abnormal_olfactory_epithelium1.45261047
74MP0000462_abnormal_digestive_system1.43202308
75MP0002085_abnormal_embryonic_tissue1.39784649
76MP0003111_abnormal_nucleus_morphology1.39770662
77MP0002066_abnormal_motor_capabilities/c1.38247863
78MP0002084_abnormal_developmental_patter1.37826248
79MP0005646_abnormal_pituitary_gland1.37079250
80MP0003123_paternal_imprinting1.36891547
81MP0003632_abnormal_nervous_system1.36242298
82MP0006276_abnormal_autonomic_nervous1.30321134
83MP0002111_abnormal_tail_morphology1.29535168
84MP0005386_behavior/neurological_phenoty1.29251282
85MP0004924_abnormal_behavior1.29251282
86MP0002557_abnormal_social/conspecific_i1.28906870
87MP0003283_abnormal_digestive_organ1.28807565
88MP0009053_abnormal_anal_canal1.28396621
89MP0009703_decreased_birth_body1.27512903
90MP0003755_abnormal_palate_morphology1.26777341
91MP0003787_abnormal_imprinting1.25598847
92MP0005248_abnormal_Harderian_gland1.25338370
93MP0004811_abnormal_neuron_physiology1.21798827
94MP0010094_abnormal_chromosome_stability1.21035155
95MP0004134_abnormal_chest_morphology1.20687522
96MP0002092_abnormal_eye_morphology1.20365940
97MP0000747_muscle_weakness1.18375356
98MP0002909_abnormal_adrenal_gland1.18284856
99MP0003631_nervous_system_phenotype1.17918345
100MP0003633_abnormal_nervous_system1.16503860
101MP0004197_abnormal_fetal_growth/weight/1.14860591
102MP0002752_abnormal_somatic_nervous1.14826283
103MP0000631_abnormal_neuroendocrine_gland1.14406548
104MP0000432_abnormal_head_morphology1.12943656
105MP0003385_abnormal_body_wall1.12795452
106MP0003136_yellow_coat_color1.12565845
107MP0003942_abnormal_urinary_system1.11011038
108MP0002152_abnormal_brain_morphology1.10073906
109MP0003077_abnormal_cell_cycle1.09609933
110MP0005409_darkened_coat_color1.09110825
111MP0006072_abnormal_retinal_apoptosis1.08824880
112MP0001963_abnormal_hearing_physiology1.08795437
113MP0008057_abnormal_DNA_replication1.08573243
114MP0001730_embryonic_growth_arrest1.08108044
115MP0001984_abnormal_olfaction1.06776069
116MP0001502_abnormal_circadian_rhythm1.05418105
117MP0003935_abnormal_craniofacial_develop1.05346467
118MP0005380_embryogenesis_phenotype1.04012712
119MP0001672_abnormal_embryogenesis/_devel1.04012712
120MP0008058_abnormal_DNA_repair1.03377121
121MP0002116_abnormal_craniofacial_bone1.02985883
122MP0003122_maternal_imprinting1.02339326
123MP0002081_perinatal_lethality1.02120071
124MP0010678_abnormal_skin_adnexa1.01917687
125MP0005187_abnormal_penis_morphology0.98790110
126MP0003718_maternal_effect0.97219343
127MP0001986_abnormal_taste_sensitivity0.96717923
128MP0005551_abnormal_eye_electrophysiolog0.96279486
129MP0005391_vision/eye_phenotype0.95952398
130MP0001346_abnormal_lacrimal_gland0.95937594
131MP0003315_abnormal_perineum_morphology0.95892463
132MP0000762_abnormal_tongue_morphology0.94869573
133MP0005379_endocrine/exocrine_gland_phen0.94720788
134MP0003183_abnormal_peptide_metabolism0.93520352
135MP0000013_abnormal_adipose_tissue0.91537361
136MP0005623_abnormal_meninges_morphology0.89446864
137MP0003984_embryonic_growth_retardation0.88798834
138MP0000604_amyloidosis0.88711992
139MP0005410_abnormal_fertilization0.87969181
140MP0001501_abnormal_sleep_pattern0.86814824
141MP0002088_abnormal_embryonic_growth/wei0.86700510
142MP0002751_abnormal_autonomic_nervous0.85853440
143MP0003115_abnormal_respiratory_system0.85730604
144MP0000026_abnormal_inner_ear0.85722861
145MP0005257_abnormal_intraocular_pressure0.84723648
146MP0001697_abnormal_embryo_size0.84392025
147MP0002249_abnormal_larynx_morphology0.84364034
148MP0003195_calcinosis0.84165274
149MP0003938_abnormal_ear_development0.83072273
150MP0003861_abnormal_nervous_system0.80009939
151MP0000751_myopathy0.77071215
152MP0000534_abnormal_ureter_morphology0.75292526
153MP0001348_abnormal_lacrimal_gland0.75070956
154MP0000003_abnormal_adipose_tissue0.73179394
155MP0001943_abnormal_respiration0.72954248
156MP0005253_abnormal_eye_physiology0.71213414
157MP0000383_abnormal_hair_follicle0.71092602
158MP0002938_white_spotting0.68549840
159MP0009250_abnormal_appendicular_skeleto0.67312978
160MP0003937_abnormal_limbs/digits/tail_de0.66954073
161MP0001177_atelectasis0.66662914
162MP0002069_abnormal_eating/drinking_beha0.66620650
163MP0003137_abnormal_impulse_conducting0.66493411
164MP0002653_abnormal_ependyma_morphology0.64976020
165MP0004147_increased_porphyrin_level0.64062226

Predicted human phenotypes

RankGene SetZ-score
1Neurofibrillary tangles (HP:0002185)5.04313172
2Degeneration of the lateral corticospinal tracts (HP:0002314)4.93853200
3Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.93853200
4Septo-optic dysplasia (HP:0100842)4.52448589
5Abnormality of the corticospinal tract (HP:0002492)4.22208123
6Hepatoblastoma (HP:0002884)4.19131683
7Supranuclear gaze palsy (HP:0000605)4.00363525
8Myokymia (HP:0002411)3.99702720
9Cerebral inclusion bodies (HP:0100314)3.85118478
10Insidious onset (HP:0003587)3.65448021
11Termporal pattern (HP:0011008)3.65448021
12Retinal dysplasia (HP:0007973)3.63033734
13Abnormality of the labia minora (HP:0012880)3.62147092
14Akinesia (HP:0002304)3.60254808
15Spastic gait (HP:0002064)3.47755644
16Ankle clonus (HP:0011448)3.44873185
17Peripheral hypomyelination (HP:0007182)3.44014986
18Pheochromocytoma (HP:0002666)3.29301761
19Colon cancer (HP:0003003)3.20929514
20Focal motor seizures (HP:0011153)3.19879995
21Cortical dysplasia (HP:0002539)3.15265424
22Action tremor (HP:0002345)3.04728826
23Sensory axonal neuropathy (HP:0003390)3.01668829
24Onion bulb formation (HP:0003383)2.98848725
25Choanal stenosis (HP:0000452)2.88251300
26Dysmetria (HP:0001310)2.86805554
27Intention tremor (HP:0002080)2.82160898
28Aplasia/Hypoplasia of the sternum (HP:0006714)2.80265404
29Scanning speech (HP:0002168)2.80257642
30Abnormal auditory evoked potentials (HP:0006958)2.79483327
31Megalencephaly (HP:0001355)2.79228152
32Alacrima (HP:0000522)2.78709240
33Neuroendocrine neoplasm (HP:0100634)2.78422346
34Maternal diabetes (HP:0009800)2.75406686
35Fetal akinesia sequence (HP:0001989)2.75345303
36Abnormality of the septum pellucidum (HP:0007375)2.74367181
37Type II lissencephaly (HP:0007260)2.72900332
38Anteriorly placed anus (HP:0001545)2.71530289
39Cutaneous syndactyly (HP:0012725)2.68228528
40Esophageal atresia (HP:0002032)2.65587891
41Cutaneous finger syndactyly (HP:0010554)2.61975941
42Focal seizures (HP:0007359)2.59688686
43Anophthalmia (HP:0000528)2.59030987
44Atonic seizures (HP:0010819)2.54846076
45Spastic diplegia (HP:0001264)2.54269749
46Bilateral microphthalmos (HP:0007633)2.54213086
47Aqueductal stenosis (HP:0002410)2.53557682
48Vitreoretinal degeneration (HP:0000655)2.50006973
49Optic nerve hypoplasia (HP:0000609)2.45785187
50Segmental peripheral demyelination/remyelination (HP:0003481)2.44876493
51High anterior hairline (HP:0009890)2.43289275
52Partial duplication of thumb phalanx (HP:0009944)2.43257872
53Lower limb muscle weakness (HP:0007340)2.42850645
54Ulnar claw (HP:0001178)2.40685676
55Increased circulating renin level (HP:0000848)2.40256627
56Hemivertebrae (HP:0002937)2.39371641
57Trigonocephaly (HP:0000243)2.38037074
58Rib fusion (HP:0000902)2.37359986
59Urinary urgency (HP:0000012)2.37301269
60Myelomeningocele (HP:0002475)2.37265295
61Turricephaly (HP:0000262)2.36938882
62Chin dimple (HP:0010751)2.34069573
63Broad thumb (HP:0011304)2.34049391
64Intestinal atresia (HP:0011100)2.32237804
65Abnormal lung lobation (HP:0002101)2.31387324
66Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.29387835
67Epileptic encephalopathy (HP:0200134)2.29250074
68Aplasia/Hypoplasia of the brainstem (HP:0007362)2.25069043
69Hypoplasia of the brainstem (HP:0002365)2.25069043
70Progressive cerebellar ataxia (HP:0002073)2.23511715
71Bronchomalacia (HP:0002780)2.23005457
72Omphalocele (HP:0001539)2.22086222
73Nephroblastoma (Wilms tumor) (HP:0002667)2.21648626
74Truncal ataxia (HP:0002078)2.21600448
75Decreased lacrimation (HP:0000633)2.21487870
76Bifid tongue (HP:0010297)2.21126365
77Split foot (HP:0001839)2.18931779
78Aplasia involving bones of the upper limbs (HP:0009823)2.17659069
79Aplasia of the phalanges of the hand (HP:0009802)2.17659069
80Aplasia involving bones of the extremities (HP:0009825)2.17659069
81Breast aplasia (HP:0100783)2.16737116
82Gowers sign (HP:0003391)2.15640430
83Preaxial foot polydactyly (HP:0001841)2.15349495
84Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.14819836
85Cerebral hypomyelination (HP:0006808)2.14309033
86Thickened helices (HP:0000391)2.13791696
87Abdominal situs inversus (HP:0003363)2.12890013
88Abnormality of abdominal situs (HP:0011620)2.12890013
89Gastrointestinal atresia (HP:0002589)2.12497767
90Renal hypoplasia (HP:0000089)2.10875774
91Parakeratosis (HP:0001036)2.10871035
92Hammertoe (HP:0001765)2.10106513
93Partial duplication of the phalanx of hand (HP:0009999)2.09310267
94Aplasia/Hypoplasia of the breasts (HP:0010311)2.08687875
95Increased nuchal translucency (HP:0010880)2.06637366
96Embryonal renal neoplasm (HP:0011794)2.05917149
97Morphological abnormality of the middle ear (HP:0008609)2.03319218
98Stenosis of the external auditory canal (HP:0000402)2.00773206
99Absent septum pellucidum (HP:0001331)1.99958568
100Clonus (HP:0002169)1.99891097
101Abnormal number of incisors (HP:0011064)1.98682423
102Abnormality of the diencephalon (HP:0010662)1.97069440
103Coronal craniosynostosis (HP:0004440)1.96249238
104Slow saccadic eye movements (HP:0000514)1.96022073
105Foot dorsiflexor weakness (HP:0009027)1.95798348
106Abnormality of the antihelix (HP:0009738)1.94455322
107Shallow orbits (HP:0000586)1.94405146
108Medulloblastoma (HP:0002885)1.94038190
109Decreased motor nerve conduction velocity (HP:0003431)1.94025355
110Humeroradial synostosis (HP:0003041)1.93357280
111Synostosis involving the elbow (HP:0003938)1.93357280
112Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.93280415
113Short 4th metacarpal (HP:0010044)1.93280415
114Difficulty running (HP:0009046)1.93114192
115Labial hypoplasia (HP:0000066)1.92086504
116Agitation (HP:0000713)1.91819746
117Steppage gait (HP:0003376)1.91461555
118Dialeptic seizures (HP:0011146)1.90770912
119Broad long bones (HP:0005622)1.89707662
120Hypoplastic female external genitalia (HP:0012815)1.89628192
121Short hallux (HP:0010109)1.89493047
122Broad phalanges of the hand (HP:0009768)1.88974772
123Broad finger (HP:0001500)1.88457556
124Absent eyebrow (HP:0002223)1.87642027
125Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.86629293
126Buphthalmos (HP:0000557)1.86476287
127Aplasia/Hypoplasia of the hallux (HP:0008362)1.86388791
128Broad metatarsal (HP:0001783)1.85644132
129Overriding aorta (HP:0002623)1.85612695
130Neuronal loss in central nervous system (HP:0002529)1.85571272
131Diminished movement (HP:0002374)1.85300253
132Hyperglycinemia (HP:0002154)1.84738315
133Morphological abnormality of the pyramidal tract (HP:0002062)1.80951463
134Abnormality of the foot musculature (HP:0001436)1.79857397
135Large for gestational age (HP:0001520)1.79808824
136Partial agenesis of the corpus callosum (HP:0001338)1.79677242
137Absent radius (HP:0003974)1.79198887
138Visual hallucinations (HP:0002367)1.78820703
139Clumsiness (HP:0002312)1.78492859
140Vertebral clefting (HP:0008428)1.77346165
141Urinary bladder sphincter dysfunction (HP:0002839)1.77141778
142Postural tremor (HP:0002174)1.76216723
143Broad phalanx (HP:0006009)1.75973626
144EEG with generalized epileptiform discharges (HP:0011198)1.75921814
145Hypomagnesemia (HP:0002917)1.75735278
146Abnormal hair whorl (HP:0010721)1.75712541
147Generalized hypotonia (HP:0001290)1.75630421
148Hypsarrhythmia (HP:0002521)1.75276692
149Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.74963203
150Epileptiform EEG discharges (HP:0011182)1.74704062
151Anxiety (HP:0000739)1.74460093
152Aplasia involving forearm bones (HP:0009822)1.74395361
153Absent forearm bone (HP:0003953)1.74395361
154Neoplasm of the peripheral nervous system (HP:0100007)1.74019845
155Excessive salivation (HP:0003781)1.73908683
156Drooling (HP:0002307)1.73908683
157Midline defect of the nose (HP:0004122)1.73830444
158Supernumerary spleens (HP:0009799)1.73535610
159Arnold-Chiari malformation (HP:0002308)1.73190927
160Hemiparesis (HP:0001269)1.72918683
161Distal sensory impairment (HP:0002936)1.72734592
162Absence seizures (HP:0002121)1.71697492
163Generalized tonic-clonic seizures (HP:0002069)1.71594090
164Hyporeflexia of lower limbs (HP:0002600)1.71008211
165Chronic bronchitis (HP:0004469)1.70796700
166Absent speech (HP:0001344)1.70545385
167Hyperventilation (HP:0002883)1.70133149
168Oligodactyly (HP:0012165)1.69808478
169Abnormality of the middle phalanges of the toes (HP:0010183)1.69771512
170Leukodystrophy (HP:0002415)1.69717848
171Depression (HP:0000716)1.69570359
172Autoamputation (HP:0001218)1.69195648
173Skull defect (HP:0001362)1.69184582
174Micropenis (HP:0000054)1.68403973
175Duplication of thumb phalanx (HP:0009942)1.68359622
176Limb dystonia (HP:0002451)1.67109450
177Dysdiadochokinesis (HP:0002075)1.66164095
178Popliteal pterygium (HP:0009756)1.65245049
179Bowel incontinence (HP:0002607)1.63686971
180Oligodactyly (hands) (HP:0001180)1.63257929
181Facial cleft (HP:0002006)1.62677399
182Erectile abnormalities (HP:0100639)1.62061001
183Scrotal hypoplasia (HP:0000046)1.60751110
1842-3 toe syndactyly (HP:0004691)1.59771086
185Broad foot (HP:0001769)1.59520443
186Selective tooth agenesis (HP:0001592)1.59016424
187Holoprosencephaly (HP:0001360)1.58632680
188Abnormality of the 4th metacarpal (HP:0010012)1.58046326
189Rocker bottom foot (HP:0001838)1.56981870
190Rhabdomyosarcoma (HP:0002859)1.55294216

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK394.55474627
2OXSR13.13435356
3MKNK12.98650442
4MKNK22.96735544
5CDC72.95149536
6MAP3K102.56073445
7SRPK12.37682232
8BCR2.36965371
9WNK42.33267903
10EPHB12.31437595
11NTRK32.29964857
12TSSK62.27173518
13NTRK12.25989393
14MARK12.21162707
15TTK2.16042684
16UHMK12.16011924
17WNK12.15381716
18MAPKAPK52.00967525
19TAF11.96717485
20LIMK11.94537399
21PNCK1.93081839
22CASK1.86315716
23CDK191.83694496
24FGFR21.75789686
25DYRK31.72958810
26PLK31.70862618
27BRD41.69438821
28PAK61.69251766
29WEE11.69209760
30LATS21.69051581
31EPHA41.66405124
32MUSK1.62219971
33PKN11.61061190
34MET1.58232063
35CSNK1A1L1.57586835
36LATS11.56256534
37TNIK1.56054623
38MAPK151.52187173
39CSNK1G31.51477681
40STK38L1.50871754
41KSR21.49760192
42NEK61.47499263
43CAMK2B1.43609393
44CSNK1G21.41612242
45MAP3K91.40254163
46TYRO31.39787580
47CAMK1D1.36676756
48VRK21.35831199
49EPHB21.34608150
50PRKD31.33787695
51PAK31.32951315
52BUB11.30883702
53PLK41.29326013
54SGK4941.26592330
55SGK2231.26592330
56CDK51.22804217
57NTRK21.22388034
58INSRR1.21990955
59ROCK21.21259291
60PRPF4B1.20313096
61CDK141.18804573
62ICK1.18397325
63MINK11.18270657
64NEK21.16449396
65FGFR11.16098914
66PHKG21.14821765
67PHKG11.14821765
68CAMK2D1.12339761
69MAP3K41.12196763
70PASK1.11876465
71CSNK1G11.09840318
72CDK121.09702652
73MAP3K21.09590832
74MAPK131.07028558
75CDK151.06001627
76BRSK21.05246437
77CDK181.05213454
78FGR1.01785142
79WNK31.00746165
80STK30.99680741
81PBK0.99273890
82ALK0.98927774
83PLK10.97608203
84MOS0.97273028
85CDK11A0.97227524
86KSR10.96074966
87CAMK2A0.94819460
88TRIM280.90898449
89MARK20.89484573
90TESK20.89239730
91HIPK20.87145166
92CAMK2G0.86810088
93DYRK20.86507601
94PDGFRA0.85418820
95CHEK20.80350081
96RPS6KA40.78117640
97ATR0.77466715
98BMX0.76174538
99CAMK1G0.75413213
100ZAK0.74747642
101PRKCE0.74612796
102IRAK20.74136717
103VRK10.73706796
104PRKCH0.72452317
105STK240.70782821
106MAP2K70.70757157
107NUAK10.70710891
108NLK0.70116775
109RET0.66719545
110ATM0.66114793
111CSNK1E0.65867185
112ERBB40.65042696
113MAP2K40.64961044
114PDGFRB0.63984003
115ARAF0.62004466
116PRKD10.60136356
117MAP3K10.59592995
118PRKDC0.58695708
119CDK30.58012326
120CHEK10.56883173
121GRK50.56172140
122YES10.56159621
123SGK20.55843116
124CDK10.55545693
125BRSK10.54492935
126STK110.54099893
127CDK20.53075880
128DDR20.52767989
129PRKCQ0.52760235
130FYN0.51821680
131DYRK1A0.51145852
132PRKCG0.50233714
133CSNK1A10.49848514
134LMTK20.49402726
135FER0.49249920
136ERBB20.49104274
137NEK10.48593363
138MAPK100.48324458
139CDK70.47519562
140FES0.46760135
141AURKB0.46561837
142CAMKK20.46259718
143PDPK10.45827960
144MAP3K120.44576222
145NME10.43256464
146PRKG10.43104044
147PRKACB0.42340996
148PLK20.41841657
149EIF2AK20.41523510
150GSK3B0.40598851
151CSNK1D0.40550439
152CDC42BPA0.40220649
153BMPR1B0.39556172
154CLK10.37829361
155DAPK20.37252354
156DMPK0.36837560
157DYRK1B0.36554912
158MAPK90.33723115

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.52252266
2Basal cell carcinoma_Homo sapiens_hsa052173.03679208
3Steroid biosynthesis_Homo sapiens_hsa001002.81663276
4Fatty acid elongation_Homo sapiens_hsa000622.55609812
5Spliceosome_Homo sapiens_hsa030402.48568365
6Mismatch repair_Homo sapiens_hsa034302.36591458
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.26600165
8DNA replication_Homo sapiens_hsa030302.21873212
9Hippo signaling pathway_Homo sapiens_hsa043902.21393733
10Cell cycle_Homo sapiens_hsa041102.05024990
11Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045502.03959361
12mRNA surveillance pathway_Homo sapiens_hsa030152.03017569
13GABAergic synapse_Homo sapiens_hsa047271.99413828
14Ether lipid metabolism_Homo sapiens_hsa005651.98527636
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.97693174
16Glutamatergic synapse_Homo sapiens_hsa047241.96814930
17Nicotine addiction_Homo sapiens_hsa050331.92461160
18RNA transport_Homo sapiens_hsa030131.91437534
19Adherens junction_Homo sapiens_hsa045201.90135356
20Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.88339197
21Non-homologous end-joining_Homo sapiens_hsa034501.88163743
22Insulin secretion_Homo sapiens_hsa049111.85719210
23Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.83546555
24Axon guidance_Homo sapiens_hsa043601.81863571
25Circadian entrainment_Homo sapiens_hsa047131.80604472
26Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.80232825
27Sulfur metabolism_Homo sapiens_hsa009201.77737454
28Synaptic vesicle cycle_Homo sapiens_hsa047211.64472818
29Maturity onset diabetes of the young_Homo sapiens_hsa049501.62002322
30Serotonergic synapse_Homo sapiens_hsa047261.61107859
31Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.60726711
32Morphine addiction_Homo sapiens_hsa050321.59792763
33Cocaine addiction_Homo sapiens_hsa050301.59283942
34Dopaminergic synapse_Homo sapiens_hsa047281.58211571
35Base excision repair_Homo sapiens_hsa034101.55141377
36Cysteine and methionine metabolism_Homo sapiens_hsa002701.54671892
37Long-term depression_Homo sapiens_hsa047301.53554409
38Basal transcription factors_Homo sapiens_hsa030221.43354627
39Protein export_Homo sapiens_hsa030601.43342636
40Amphetamine addiction_Homo sapiens_hsa050311.42388852
41Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.42121656
42Selenocompound metabolism_Homo sapiens_hsa004501.41459677
43Long-term potentiation_Homo sapiens_hsa047201.38775059
44Taste transduction_Homo sapiens_hsa047421.38555225
45Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.36414683
46Cholinergic synapse_Homo sapiens_hsa047251.36339354
47RNA degradation_Homo sapiens_hsa030181.34157568
48Notch signaling pathway_Homo sapiens_hsa043301.32867372
49Salivary secretion_Homo sapiens_hsa049701.32436574
50Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.31671340
51Sphingolipid metabolism_Homo sapiens_hsa006001.28637844
52Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.26267679
53Olfactory transduction_Homo sapiens_hsa047401.23814874
54RNA polymerase_Homo sapiens_hsa030201.23722219
55Vibrio cholerae infection_Homo sapiens_hsa051101.23276614
56Colorectal cancer_Homo sapiens_hsa052101.23130138
57MicroRNAs in cancer_Homo sapiens_hsa052061.21013782
58Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.19358169
59Gastric acid secretion_Homo sapiens_hsa049711.17527721
60Pancreatic secretion_Homo sapiens_hsa049721.15638408
61Gap junction_Homo sapiens_hsa045401.15613797
62Biosynthesis of amino acids_Homo sapiens_hsa012301.12063521
63TGF-beta signaling pathway_Homo sapiens_hsa043501.11682716
64Dorso-ventral axis formation_Homo sapiens_hsa043201.10949100
65Fanconi anemia pathway_Homo sapiens_hsa034601.09270634
66Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.08933426
67Renal cell carcinoma_Homo sapiens_hsa052111.08603693
68Oocyte meiosis_Homo sapiens_hsa041141.07316400
69Renin secretion_Homo sapiens_hsa049241.04620944
70Thyroid cancer_Homo sapiens_hsa052161.04440118
71Lysine degradation_Homo sapiens_hsa003101.02862166
72Ribosome_Homo sapiens_hsa030101.02165592
73Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.02163393
74ErbB signaling pathway_Homo sapiens_hsa040121.00946283
75Collecting duct acid secretion_Homo sapiens_hsa049660.98390888
76Aldosterone synthesis and secretion_Homo sapiens_hsa049250.96478619
77Nucleotide excision repair_Homo sapiens_hsa034200.94849521
78Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.94585684
79Tight junction_Homo sapiens_hsa045300.94580545
80Homologous recombination_Homo sapiens_hsa034400.94104754
81Butanoate metabolism_Homo sapiens_hsa006500.93588256
82Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.93389294
83Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.93029253
84Vascular smooth muscle contraction_Homo sapiens_hsa042700.92809333
85Endometrial cancer_Homo sapiens_hsa052130.92200503
86Sphingolipid signaling pathway_Homo sapiens_hsa040710.91241302
87Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.91053258
88Cardiac muscle contraction_Homo sapiens_hsa042600.89925793
89Phospholipase D signaling pathway_Homo sapiens_hsa040720.89183028
90Type II diabetes mellitus_Homo sapiens_hsa049300.87973357
91Pyruvate metabolism_Homo sapiens_hsa006200.87070543
92Hedgehog signaling pathway_Homo sapiens_hsa043400.86657602
93cAMP signaling pathway_Homo sapiens_hsa040240.86652384
94Oxytocin signaling pathway_Homo sapiens_hsa049210.86601320
95One carbon pool by folate_Homo sapiens_hsa006700.86580596
96Propanoate metabolism_Homo sapiens_hsa006400.84786463
97SNARE interactions in vesicular transport_Homo sapiens_hsa041300.84037374
98Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.83413404
99Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.82420333
100Endocytosis_Homo sapiens_hsa041440.81170809
101GnRH signaling pathway_Homo sapiens_hsa049120.80538484
102Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.79269063
103Oxidative phosphorylation_Homo sapiens_hsa001900.79265731
104Linoleic acid metabolism_Homo sapiens_hsa005910.78058180
105Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.77978080
106Calcium signaling pathway_Homo sapiens_hsa040200.77690658
107Ras signaling pathway_Homo sapiens_hsa040140.77592718
108Melanogenesis_Homo sapiens_hsa049160.77466653
109Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.77255771
110Alzheimers disease_Homo sapiens_hsa050100.76721521
111Estrogen signaling pathway_Homo sapiens_hsa049150.75905352
112Central carbon metabolism in cancer_Homo sapiens_hsa052300.74046293
113alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.73225893
114Phosphatidylinositol signaling system_Homo sapiens_hsa040700.71774685
115Ovarian steroidogenesis_Homo sapiens_hsa049130.70061620
116Prostate cancer_Homo sapiens_hsa052150.69094719
117Choline metabolism in cancer_Homo sapiens_hsa052310.67837747
118Prion diseases_Homo sapiens_hsa050200.67392429
119Glioma_Homo sapiens_hsa052140.67304785
120Protein digestion and absorption_Homo sapiens_hsa049740.66238807
121cGMP-PKG signaling pathway_Homo sapiens_hsa040220.65131943
122Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.64568159
123Melanoma_Homo sapiens_hsa052180.63589643
124Pathways in cancer_Homo sapiens_hsa052000.63408449
125Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.63372327
126p53 signaling pathway_Homo sapiens_hsa041150.62999332
127Thyroid hormone synthesis_Homo sapiens_hsa049180.62873031
1282-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.62722905
129Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.62470320
130Vitamin B6 metabolism_Homo sapiens_hsa007500.61554747
131Wnt signaling pathway_Homo sapiens_hsa043100.60600710
132Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.59096563
133Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.58023452
134Histidine metabolism_Homo sapiens_hsa003400.57062238
135Dilated cardiomyopathy_Homo sapiens_hsa054140.55443062
136MAPK signaling pathway_Homo sapiens_hsa040100.55275093
137Nitrogen metabolism_Homo sapiens_hsa009100.54996512
138Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.54828886
139Huntingtons disease_Homo sapiens_hsa050160.54533059
140Phototransduction_Homo sapiens_hsa047440.54275314
141Thyroid hormone signaling pathway_Homo sapiens_hsa049190.53971867
142Carbohydrate digestion and absorption_Homo sapiens_hsa049730.52733225
143Alcoholism_Homo sapiens_hsa050340.52687480
144Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.52648414
145Parkinsons disease_Homo sapiens_hsa050120.52074740
146Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.49499840
147Carbon metabolism_Homo sapiens_hsa012000.48417695
148Lysosome_Homo sapiens_hsa041420.48272944
149Glycerophospholipid metabolism_Homo sapiens_hsa005640.47485434
150ECM-receptor interaction_Homo sapiens_hsa045120.45942556
151Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.43301395
152Vitamin digestion and absorption_Homo sapiens_hsa049770.42958020
153Arginine and proline metabolism_Homo sapiens_hsa003300.41779311
154Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.41283119
155Fatty acid metabolism_Homo sapiens_hsa012120.40692524
156Regulation of autophagy_Homo sapiens_hsa041400.39217686
157Purine metabolism_Homo sapiens_hsa002300.38618783
158Rap1 signaling pathway_Homo sapiens_hsa040150.38466726
159Proteasome_Homo sapiens_hsa030500.37059185
160Inositol phosphate metabolism_Homo sapiens_hsa005620.37034769
161Proteoglycans in cancer_Homo sapiens_hsa052050.36040560
162Mineral absorption_Homo sapiens_hsa049780.35419082
163Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.34427892

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