LRRN4CL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)5.55435695
2axon ensheathment in central nervous system (GO:0032291)4.60857089
3central nervous system myelination (GO:0022010)4.60857089
4long-chain fatty acid biosynthetic process (GO:0042759)4.48864765
5extracellular fibril organization (GO:0043206)4.31860324
6extracellular regulation of signal transduction (GO:1900115)4.26994709
7extracellular negative regulation of signal transduction (GO:1900116)4.26994709
8regulation of hippo signaling (GO:0035330)3.99395886
9mesenchymal cell differentiation involved in kidney development (GO:0072161)3.83011984
10mesenchymal cell differentiation involved in renal system development (GO:2001012)3.83011984
11import into cell (GO:0098657)3.82956950
12type B pancreatic cell proliferation (GO:0044342)3.82331094
13L-fucose catabolic process (GO:0042355)3.78268890
14fucose catabolic process (GO:0019317)3.78268890
15L-fucose metabolic process (GO:0042354)3.78268890
16presynaptic membrane assembly (GO:0097105)3.77754895
17fibril organization (GO:0097435)3.69397632
18negative regulation of myoblast differentiation (GO:0045662)3.67334886
19sequestering of extracellular ligand from receptor (GO:0035581)3.63491433
20blood vessel maturation (GO:0001955)3.55856961
21negative regulation of protein localization to cell surface (GO:2000009)3.54799198
22nephron tubule morphogenesis (GO:0072078)3.50039894
23nephron epithelium morphogenesis (GO:0072088)3.50039894
24cerebral cortex radially oriented cell migration (GO:0021799)3.48453895
25adhesion of symbiont to host cell (GO:0044650)3.45513985
26virion attachment to host cell (GO:0019062)3.45513985
27positive regulation of gastrulation (GO:2000543)3.40953646
28presynaptic membrane organization (GO:0097090)3.40317056
29retina vasculature morphogenesis in camera-type eye (GO:0061299)3.36005610
30platelet dense granule organization (GO:0060155)3.19665245
31response to redox state (GO:0051775)3.18937283
32extracellular matrix assembly (GO:0085029)3.17291411
33cell differentiation involved in metanephros development (GO:0072202)3.17011193
34protein heterotrimerization (GO:0070208)3.11446565
35urinary tract smooth muscle contraction (GO:0014848)3.09783357
36alanine transport (GO:0032328)3.07132767
37negative regulation of leukocyte chemotaxis (GO:0002689)2.99558609
38detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.99453184
39renal tubule morphogenesis (GO:0061333)2.99100172
40negative regulation of synaptic transmission, GABAergic (GO:0032229)2.94829539
41collagen fibril organization (GO:0030199)2.93061215
42keratinocyte development (GO:0003334)2.90922375
43positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.83902126
44positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)2.80736765
45keratan sulfate catabolic process (GO:0042340)2.80286752
46neuron remodeling (GO:0016322)2.78320108
47peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.77776276
48neuronal action potential (GO:0019228)2.76670238
49dermatan sulfate biosynthetic process (GO:0030208)2.76089480
50limb bud formation (GO:0060174)2.75965244
51short-term memory (GO:0007614)2.74889437
52postsynaptic membrane organization (GO:0001941)2.74130379
53startle response (GO:0001964)2.73902453
54developmental pigmentation (GO:0048066)2.73135700
55cranial nerve morphogenesis (GO:0021602)2.72900800
56detection of light stimulus involved in sensory perception (GO:0050962)2.72520859
57detection of light stimulus involved in visual perception (GO:0050908)2.72520859
58cornea development in camera-type eye (GO:0061303)2.71874047
59peripheral nervous system axon ensheathment (GO:0032292)2.69935193
60myelination in peripheral nervous system (GO:0022011)2.69935193
61protein-cofactor linkage (GO:0018065)2.69407722
62isoprenoid biosynthetic process (GO:0008299)2.67766852
63polyol transport (GO:0015791)2.67362873
64parturition (GO:0007567)2.67100034
65positive regulation of synapse assembly (GO:0051965)2.66593605
66head development (GO:0060322)2.66121841
67negative regulation of neurotransmitter transport (GO:0051589)2.65472094
68negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)2.64774111
69regulation of gene silencing by RNA (GO:0060966)2.64440326
70regulation of posttranscriptional gene silencing (GO:0060147)2.64440326
71regulation of gene silencing by miRNA (GO:0060964)2.64440326
72adhesion of symbiont to host (GO:0044406)2.64248595
73regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.62935694
74synaptic transmission, cholinergic (GO:0007271)2.62110961
75myelination (GO:0042552)2.61971640
76cellular ketone body metabolic process (GO:0046950)2.61924970
77photoreceptor cell differentiation (GO:0046530)2.61471337
78eye photoreceptor cell differentiation (GO:0001754)2.61471337
79mesonephros development (GO:0001823)2.61049167
80sulfation (GO:0051923)2.60621695
81positive regulation of uterine smooth muscle contraction (GO:0070474)2.59515896
82regulation of action potential (GO:0098900)2.58615182
83behavioral response to pain (GO:0048266)2.58122026
84negative regulation of telomere maintenance (GO:0032205)2.57951243
85positive regulation of fatty acid oxidation (GO:0046321)2.57555362
86cell proliferation in forebrain (GO:0021846)2.57152136
87bone trabecula formation (GO:0060346)2.55173470
88fucosylation (GO:0036065)2.54649218
89metanephric mesenchyme development (GO:0072075)2.53658363
90cilium morphogenesis (GO:0060271)2.53502791
91regulation of sequestering of triglyceride (GO:0010889)2.53432435
92GPI anchor biosynthetic process (GO:0006506)2.51857107
93ketone body metabolic process (GO:1902224)2.51677410
94water-soluble vitamin biosynthetic process (GO:0042364)2.51343608
95negative regulation of leukocyte migration (GO:0002686)2.50969567
96superoxide anion generation (GO:0042554)2.50240933
97purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.50185253
983-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.50185253
99chondrocyte proliferation (GO:0035988)2.50001434
100kidney morphogenesis (GO:0060993)2.49974541
101fatty acid elongation (GO:0030497)2.49475511
102astrocyte development (GO:0014002)2.49252259
103protein polyglutamylation (GO:0018095)2.49148867
104chondroitin sulfate catabolic process (GO:0030207)2.48988926
105negative regulation of keratinocyte proliferation (GO:0010839)2.48981516
106axon ensheathment (GO:0008366)2.48912330
107ensheathment of neurons (GO:0007272)2.48912330
108auditory receptor cell stereocilium organization (GO:0060088)2.48104939
109negative regulation of mast cell activation (GO:0033004)2.45979307
110G-protein coupled receptor internalization (GO:0002031)2.45950413
111preassembly of GPI anchor in ER membrane (GO:0016254)2.44768808
112dermatan sulfate metabolic process (GO:0030205)2.44762509
113peristalsis (GO:0030432)2.43778372
114detection of molecule of bacterial origin (GO:0032490)2.43398028
115positive regulation of action potential (GO:0045760)2.43145006
116epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.43027354
117neuron cell-cell adhesion (GO:0007158)2.42328735
118omega-hydroxylase P450 pathway (GO:0097267)2.42199808
119cellular response to vitamin (GO:0071295)2.40269739
120regulation of timing of cell differentiation (GO:0048505)2.40020626
121phasic smooth muscle contraction (GO:0014821)2.39663782
122cellular response to ATP (GO:0071318)2.39643335
123smooth muscle contraction (GO:0006939)2.39364995
124retinal cone cell development (GO:0046549)2.38495516
125inner ear receptor stereocilium organization (GO:0060122)2.38431780
126positive regulation of fatty acid beta-oxidation (GO:0032000)2.37727926
127axoneme assembly (GO:0035082)2.37510493
128regulation of rhodopsin mediated signaling pathway (GO:0022400)2.35386054
129GPI anchor metabolic process (GO:0006505)2.35307317
130ubiquinone biosynthetic process (GO:0006744)2.35270485
131negative regulation of reactive oxygen species metabolic process (GO:2000378)2.35065323
132regulation of mesoderm development (GO:2000380)2.34628778
133inner ear receptor cell development (GO:0060119)2.33623431
134ganglion development (GO:0061548)2.33549632
135negative regulation of neurotransmitter secretion (GO:0046929)2.33466275
136mesenchymal cell differentiation (GO:0048762)2.33397021
137rhodopsin mediated signaling pathway (GO:0016056)2.32434807
138kidney mesenchyme development (GO:0072074)2.31434892
139regulation of keratinocyte proliferation (GO:0010837)2.31326072
140regulation of interleukin-8 secretion (GO:2000482)2.31142665
141serotonin receptor signaling pathway (GO:0007210)2.30743696
142ubiquinone metabolic process (GO:0006743)2.29770487
143mitotic cell cycle arrest (GO:0071850)2.29684869
144smooth muscle tissue development (GO:0048745)2.29433658
145collagen catabolic process (GO:0030574)2.28921765
146cell differentiation involved in kidney development (GO:0061005)2.28865323
147organ growth (GO:0035265)2.28794459
148opsonization (GO:0008228)2.28528695
149membrane assembly (GO:0071709)2.28419252
150glycerophospholipid catabolic process (GO:0046475)2.28252876
151response to pheromone (GO:0019236)2.28069327
152mesenchymal-epithelial cell signaling (GO:0060638)2.28017675
153cAMP catabolic process (GO:0006198)2.26839204
154regulation of myoblast differentiation (GO:0045661)2.26352163
155dentate gyrus development (GO:0021542)2.25840202
156oligodendrocyte differentiation (GO:0048709)2.25451253
157collagen metabolic process (GO:0032963)2.25443755
158indole-containing compound catabolic process (GO:0042436)2.22407932
159indolalkylamine catabolic process (GO:0046218)2.22407932
160tryptophan catabolic process (GO:0006569)2.22407932
161protein complex biogenesis (GO:0070271)2.21902810
162facial nerve structural organization (GO:0021612)2.21808198
163negative regulation of protein autophosphorylation (GO:0031953)2.21382967
164regulation of chemokine-mediated signaling pathway (GO:0070099)2.20930519
165cell migration involved in heart development (GO:0060973)2.20844631
166regulation of pigment cell differentiation (GO:0050932)2.20659407
167cerebral cortex cell migration (GO:0021795)2.20056722
168indolalkylamine metabolic process (GO:0006586)2.19751663
169cyclic nucleotide catabolic process (GO:0009214)2.19729712
170regulation of non-canonical Wnt signaling pathway (GO:2000050)2.18922396
171somite development (GO:0061053)2.17887961
172lymphangiogenesis (GO:0001946)2.17662600
173negative regulation of macrophage differentiation (GO:0045650)2.17265297
174kynurenine metabolic process (GO:0070189)2.15176314
175epithelial cilium movement (GO:0003351)2.15127643

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human4.62079931
2ZNF274_21170338_ChIP-Seq_K562_Hela3.33379091
3EZH2_22144423_ChIP-Seq_EOC_Human3.20599801
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.70108870
5ZFP57_27257070_Chip-Seq_ESCs_Mouse2.58623348
6EED_16625203_ChIP-ChIP_MESCs_Mouse2.51758047
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.37456588
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.31460012
9SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.29544042
10SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.29343230
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.26783415
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.25633941
13TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.17920474
14BMI1_23680149_ChIP-Seq_NPCS_Mouse2.14951094
15HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.12250574
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.07467038
17RNF2_18974828_ChIP-Seq_MESCs_Mouse2.06813286
18EZH2_18974828_ChIP-Seq_MESCs_Mouse2.06813286
19TAF15_26573619_Chip-Seq_HEK293_Human2.04865534
20PCGF2_27294783_Chip-Seq_ESCs_Mouse2.04378346
21SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.03860675
22JARID2_20075857_ChIP-Seq_MESCs_Mouse1.94012186
23SUZ12_27294783_Chip-Seq_NPCs_Mouse1.89886364
24POU3F2_20337985_ChIP-ChIP_501MEL_Human1.87319189
25CBX2_27304074_Chip-Seq_ESCs_Mouse1.84478908
26CDX2_19796622_ChIP-Seq_MESCs_Mouse1.84304299
27RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.83695781
28FLI1_27457419_Chip-Seq_LIVER_Mouse1.82724464
29TRIM28_21343339_ChIP-Seq_HEK293_Human1.81032703
30PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.79734865
31PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.77974426
32CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.75793274
33POU5F1_16153702_ChIP-ChIP_HESCs_Human1.73492714
34NFE2_27457419_Chip-Seq_LIVER_Mouse1.72396552
35PCGF2_27294783_Chip-Seq_NPCs_Mouse1.71121449
36PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.68173431
37IGF1R_20145208_ChIP-Seq_DFB_Human1.66130504
38EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.65350380
39FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.64511661
40NANOG_18555785_Chip-Seq_ESCs_Mouse1.64222443
41TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.64168147
42EZH2_27294783_Chip-Seq_ESCs_Mouse1.63456731
43P300_19829295_ChIP-Seq_ESCs_Human1.60763367
44PIAS1_25552417_ChIP-Seq_VCAP_Human1.59732322
45TP53_18474530_ChIP-ChIP_U2OS_Human1.58582588
46MTF2_20144788_ChIP-Seq_MESCs_Mouse1.57672529
47BP1_19119308_ChIP-ChIP_Hs578T_Human1.57550853
48RNF2_27304074_Chip-Seq_ESCs_Mouse1.57263515
49SUZ12_18555785_Chip-Seq_ESCs_Mouse1.56397096
50E2F1_18555785_Chip-Seq_ESCs_Mouse1.54423956
51SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.53671216
52EZH2_27294783_Chip-Seq_NPCs_Mouse1.53247976
53P53_22387025_ChIP-Seq_ESCs_Mouse1.52780062
54EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.52706560
55ER_23166858_ChIP-Seq_MCF-7_Human1.52670068
56SMAD_19615063_ChIP-ChIP_OVARY_Human1.52084627
57MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.51940645
58EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.48418751
59STAT3_18555785_Chip-Seq_ESCs_Mouse1.47359523
60SUZ12_27294783_Chip-Seq_ESCs_Mouse1.46639780
61BCAT_22108803_ChIP-Seq_LS180_Human1.45456356
62SMAD4_21799915_ChIP-Seq_A2780_Human1.44112019
63P300_18555785_Chip-Seq_ESCs_Mouse1.42538981
64AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.42025523
65CMYC_18555785_Chip-Seq_ESCs_Mouse1.41992842
66AR_25329375_ChIP-Seq_VCAP_Human1.41151849
67CTBP1_25329375_ChIP-Seq_LNCAP_Human1.40950967
68EWS_26573619_Chip-Seq_HEK293_Human1.40671521
69VDR_22108803_ChIP-Seq_LS180_Human1.40587415
70OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40301485
71SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40276277
72NMYC_18555785_Chip-Seq_ESCs_Mouse1.39500048
73NR3C1_21868756_ChIP-Seq_MCF10A_Human1.39053103
74WT1_19549856_ChIP-ChIP_CCG9911_Human1.38448818
75SOX2_18555785_Chip-Seq_ESCs_Mouse1.35902745
76RNF2_27304074_Chip-Seq_NSC_Mouse1.34386852
77CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.34132584
78TP53_16413492_ChIP-PET_HCT116_Human1.33130282
79SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.33043574
80FUS_26573619_Chip-Seq_HEK293_Human1.32569980
81CTBP2_25329375_ChIP-Seq_LNCAP_Human1.32476467
82TAL1_26923725_Chip-Seq_HPCs_Mouse1.29734574
83ZFX_18555785_Chip-Seq_ESCs_Mouse1.29544977
84RUNX1_27457419_Chip-Seq_LIVER_Mouse1.28920495
85OCT4_18555785_Chip-Seq_ESCs_Mouse1.27848597
86PU1_27457419_Chip-Seq_LIVER_Mouse1.27004798
87TP53_22573176_ChIP-Seq_HFKS_Human1.26705612
88SMAD3_21741376_ChIP-Seq_EPCs_Human1.25313871
89KDM2B_26808549_Chip-Seq_REH_Human1.25068446
90AR_21572438_ChIP-Seq_LNCaP_Human1.24858182
91UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.24310460
92EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.24169179
93KLF4_18555785_Chip-Seq_ESCs_Mouse1.23511313
94TOP2B_26459242_ChIP-Seq_MCF-7_Human1.23307881
95NRF2_20460467_ChIP-Seq_MEFs_Mouse1.22653897
96NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.22653897
97HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.21934350
98DROSHA_22980978_ChIP-Seq_HELA_Human1.20670810
99ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.20606177
100FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.20250698
101SALL1_21062744_ChIP-ChIP_HESCs_Human1.20116236
102* ETV2_25802403_ChIP-Seq_MESCs_Mouse1.19469293
103SMAD1_18555785_Chip-Seq_ESCs_Mouse1.19138924
104CRX_20693478_ChIP-Seq_RETINA_Mouse1.17662960
105ESRRB_18555785_Chip-Seq_ESCs_Mouse1.16706619
106RUNX2_22187159_ChIP-Seq_PCA_Human1.16422569
107POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.14040797
108TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14040797
109IKZF1_21737484_ChIP-ChIP_HCT116_Human1.14010519
110CJUN_26792858_Chip-Seq_BT549_Human1.13815071
111* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.12845673
112* FOXA1_25329375_ChIP-Seq_VCAP_Human1.12845673
113CTCF_18555785_Chip-Seq_ESCs_Mouse1.12530848
114GATA3_21878914_ChIP-Seq_MCF-7_Human1.11676571
115VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.11429456
116CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.11292238
117TCF4_23295773_ChIP-Seq_U87_Human1.10831645
118CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.09899019
119BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.09783274
120SMAD4_21741376_ChIP-Seq_EPCs_Human1.08687221
121SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.08677218
122MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.08537341
123CBP_20019798_ChIP-Seq_JUKART_Human1.07300764
124IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.07300764
125STAT3_23295773_ChIP-Seq_U87_Human1.06828333
126REST_21632747_ChIP-Seq_MESCs_Mouse1.06746528
127NANOG_19829295_ChIP-Seq_ESCs_Human1.04656898
128SOX2_19829295_ChIP-Seq_ESCs_Human1.04656898
129TCF4_22108803_ChIP-Seq_LS180_Human1.03807595
130RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03377031
131AR_20517297_ChIP-Seq_VCAP_Human1.01179682
132IRF1_19129219_ChIP-ChIP_H3396_Human0.98097398

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.79712773
2MP0005503_abnormal_tendon_morphology4.57818656
3MP0005275_abnormal_skin_tensile3.69576411
4MP0005171_absent_coat_pigmentation3.31422567
5MP0001986_abnormal_taste_sensitivity3.24827410
6MP0001188_hyperpigmentation3.20728269
7MP0005423_abnormal_somatic_nervous2.55211261
8MP0001958_emphysema2.53356322
9MP0006054_spinal_hemorrhage2.38588160
10MP0000569_abnormal_digit_pigmentation2.32639253
11MP0005257_abnormal_intraocular_pressure2.26704146
12MP0010386_abnormal_urinary_bladder2.14043850
13MP0002102_abnormal_ear_morphology2.13204464
14MP0005409_darkened_coat_color2.13123266
15MP0003279_aneurysm2.10513593
16MP0003880_abnormal_central_pattern2.09867108
17MP0003283_abnormal_digestive_organ1.99530767
18MP0000372_irregular_coat_pigmentation1.94035158
19MP0004885_abnormal_endolymph1.92926034
20MP0003950_abnormal_plasma_membrane1.78429895
21MP0005174_abnormal_tail_pigmentation1.75991331
22MP0009250_abnormal_appendicular_skeleto1.73053159
23MP0002108_abnormal_muscle_morphology1.67792269
24MP0003646_muscle_fatigue1.66940131
25MP0003724_increased_susceptibility_to1.66714601
26MP0009379_abnormal_foot_pigmentation1.66572836
27MP0003136_yellow_coat_color1.66103149
28MP0005508_abnormal_skeleton_morphology1.65940871
29MP0003195_calcinosis1.64578669
30MP0009384_cardiac_valve_regurgitation1.60304573
31MP0003941_abnormal_skin_development1.56575132
32MP0006276_abnormal_autonomic_nervous1.55929240
33MP0000049_abnormal_middle_ear1.55591380
34MP0006292_abnormal_olfactory_placode1.51616991
35MP0001542_abnormal_bone_strength1.51336682
36MP0000566_synostosis1.50461220
37MP0002277_abnormal_respiratory_mucosa1.48254334
38MP0002163_abnormal_gland_morphology1.44944041
39MP0001486_abnormal_startle_reflex1.43718582
40MP0002254_reproductive_system_inflammat1.43643783
41MP0004742_abnormal_vestibular_system1.43634136
42MP0000013_abnormal_adipose_tissue1.42732398
43MP0004272_abnormal_basement_membrane1.41726801
44MP0002938_white_spotting1.38921824
45MP0005084_abnormal_gallbladder_morpholo1.38630402
46MP0002933_joint_inflammation1.37864529
47MP0006072_abnormal_retinal_apoptosis1.33285708
48MP0005379_endocrine/exocrine_gland_phen1.31051143
49MP0004134_abnormal_chest_morphology1.30380723
50MP0000920_abnormal_myelination1.28613856
51MP0002295_abnormal_pulmonary_circulatio1.27121455
52MP0000751_myopathy1.25883712
53MP0004147_increased_porphyrin_level1.24855956
54MP0003385_abnormal_body_wall1.24844767
55MP0005645_abnormal_hypothalamus_physiol1.24822607
56MP0004043_abnormal_pH_regulation1.24290651
57MP0004133_heterotaxia1.22042166
58MP0002736_abnormal_nociception_after1.21574849
59MP0005551_abnormal_eye_electrophysiolog1.18611441
60MP0001177_atelectasis1.16175265
61MP0000762_abnormal_tongue_morphology1.16141644
62MP0002060_abnormal_skin_morphology1.15958490
63MP0002249_abnormal_larynx_morphology1.15889906
64MP0002735_abnormal_chemical_nociception1.15216727
65MP0005253_abnormal_eye_physiology1.12759933
66MP0002272_abnormal_nervous_system1.11755675
67MP0008875_abnormal_xenobiotic_pharmacok1.11638349
68MP0002653_abnormal_ependyma_morphology1.10988074
69MP0004381_abnormal_hair_follicle1.10351784
70MP0000230_abnormal_systemic_arterial1.09779904
71MP0001968_abnormal_touch/_nociception1.09518523
72MP0005390_skeleton_phenotype1.09203072
73MP0004215_abnormal_myocardial_fiber1.08933956
74MP0001529_abnormal_vocalization1.08070831
75MP0001970_abnormal_pain_threshold1.06033139
76MP0000538_abnormal_urinary_bladder1.02883076
77MP0008872_abnormal_physiological_respon1.02363725
78MP0000015_abnormal_ear_pigmentation1.00627725
79MP0005595_abnormal_vascular_smooth0.99883144
80MP0001502_abnormal_circadian_rhythm0.99662394
81MP0003011_delayed_dark_adaptation0.99228520
82MP0005083_abnormal_biliary_tract0.98204657
83MP0004142_abnormal_muscle_tone0.97231649
84MP0000026_abnormal_inner_ear0.94991517
85MP0004130_abnormal_muscle_cell0.94829138
86MP0003787_abnormal_imprinting0.94802519
87MP0002638_abnormal_pupillary_reflex0.94594506
88MP0001963_abnormal_hearing_physiology0.94288807
89MP0002876_abnormal_thyroid_physiology0.91653535
90MP0000383_abnormal_hair_follicle0.90265907
91MP0002234_abnormal_pharynx_morphology0.89571855
92MP0001905_abnormal_dopamine_level0.88755759
93MP0000163_abnormal_cartilage_morphology0.88603589
94MP0000749_muscle_degeneration0.88557519
95MP0003045_fibrosis0.88303930
96MP0000778_abnormal_nervous_system0.87974130
97MP0002733_abnormal_thermal_nociception0.87850663
98MP0000750_abnormal_muscle_regeneration0.86931862
99MP0003137_abnormal_impulse_conducting0.86465721
100MP0005388_respiratory_system_phenotype0.86358189
101MP0002133_abnormal_respiratory_system0.86358189
102MP0001243_abnormal_dermal_layer0.86243166
103MP0004484_altered_response_of0.86211155
104MP0002095_abnormal_skin_pigmentation0.86144118
105MP0005075_abnormal_melanosome_morpholog0.85976562
106MP0002837_dystrophic_cardiac_calcinosis0.85714644
107MP0002160_abnormal_reproductive_system0.84117981
108MP0009780_abnormal_chondrocyte_physiolo0.83897694
109MP0001299_abnormal_eye_distance/0.83770303
110MP0001501_abnormal_sleep_pattern0.81776392
111MP0000427_abnormal_hair_cycle0.81602011
112MP0003755_abnormal_palate_morphology0.79331656
113MP0000678_abnormal_parathyroid_gland0.78152275
114MP0001485_abnormal_pinna_reflex0.78143831
115MP0002282_abnormal_trachea_morphology0.76319312
116MP0002168_other_aberrant_phenotype0.75533876
117MP0001324_abnormal_eye_pigmentation0.74533550
118MP0005646_abnormal_pituitary_gland0.74054135
119MP0002572_abnormal_emotion/affect_behav0.73580009
120MP0000371_diluted_coat_color0.73221067
121MP0005389_reproductive_system_phenotype0.72911078
122MP0005195_abnormal_posterior_eye0.72705263
123MP0002998_abnormal_bone_remodeling0.72692054
124MP0000343_altered_response_to0.72550125
125MP0001756_abnormal_urination0.72353772
126MP0005620_abnormal_muscle_contractility0.71542667
127MP0009745_abnormal_behavioral_response0.70152256
128MP0002557_abnormal_social/conspecific_i0.70032420
129MP0001533_abnormal_skeleton_physiology0.69650975
130MP0000767_abnormal_smooth_muscle0.69117056
131MP0005670_abnormal_white_adipose0.68932265
132MP0008775_abnormal_heart_ventricle0.68703394
133MP0000631_abnormal_neuroendocrine_gland0.68352061
134MP0000681_abnormal_thyroid_gland0.68237502
135MP0005164_abnormal_response_to0.68219992
136MP0005369_muscle_phenotype0.68027662
137MP0009046_muscle_twitch0.67694650
138MP0001346_abnormal_lacrimal_gland0.66144147
139MP0004145_abnormal_muscle_electrophysio0.65961366
140MP0002734_abnormal_mechanical_nocicepti0.65832706
141MP0003938_abnormal_ear_development0.64538071
142MP0002177_abnormal_outer_ear0.64426468
143MP0002752_abnormal_somatic_nervous0.64079988
144MP0010771_integument_phenotype0.61558118
145MP0002115_abnormal_skeleton_extremities0.61082986
146MP0002067_abnormal_sensory_capabilities0.60533531

Predicted human phenotypes

RankGene SetZ-score
1Parakeratosis (HP:0001036)4.88915086
2Premature rupture of membranes (HP:0001788)4.58987396
3Duplicated collecting system (HP:0000081)4.57145331
4Abnormality of the renal collecting system (HP:0004742)4.55641208
5Congenital sensorineural hearing impairment (HP:0008527)3.88781883
6Wrist flexion contracture (HP:0001239)3.86934738
7Type II lissencephaly (HP:0007260)3.81922303
8Molar tooth sign on MRI (HP:0002419)3.75741739
9Abnormality of midbrain morphology (HP:0002418)3.75741739
10Soft skin (HP:0000977)3.64820054
11Follicular hyperkeratosis (HP:0007502)3.50143106
12Mesangial abnormality (HP:0001966)3.32767668
13Slender build (HP:0001533)3.15520321
14Chromosomal breakage induced by crosslinking agents (HP:0003221)3.09573622
15Pancreatic cysts (HP:0001737)3.04669335
16White forelock (HP:0002211)3.01554540
17Protrusio acetabuli (HP:0003179)3.00325335
18Atelectasis (HP:0100750)2.98946556
19Nephronophthisis (HP:0000090)2.98424471
20Pancreatic fibrosis (HP:0100732)2.95280620
21Atrophic scars (HP:0001075)2.93823332
22Patchy hypopigmentation of hair (HP:0011365)2.87345353
23True hermaphroditism (HP:0010459)2.87099933
24Corneal dystrophy (HP:0001131)2.80888855
25Congenital stationary night blindness (HP:0007642)2.80806373
26Chromsome breakage (HP:0040012)2.78159008
27Septo-optic dysplasia (HP:0100842)2.76679419
28Abnormality of the renal medulla (HP:0100957)2.75112517
29Bulbous nose (HP:0000414)2.74879430
30Increased corneal curvature (HP:0100692)2.74086280
31Keratoconus (HP:0000563)2.74086280
32Hyperventilation (HP:0002883)2.69354608
33Tubular atrophy (HP:0000092)2.68982173
34Abnormality of the renal cortex (HP:0011035)2.67824806
35Congenital, generalized hypertrichosis (HP:0004540)2.67189866
36Large for gestational age (HP:0001520)2.67182263
37Vascular tortuosity (HP:0004948)2.60315634
38Pulmonary artery stenosis (HP:0004415)2.56549290
39Vertebral compression fractures (HP:0002953)2.55687250
40Bradycardia (HP:0001662)2.55102133
41Wormian bones (HP:0002645)2.52033515
42Absent septum pellucidum (HP:0001331)2.48882417
43Chin dimple (HP:0010751)2.47371262
44Arterial tortuosity (HP:0005116)2.45245041
45Coronal craniosynostosis (HP:0004440)2.45035961
46Upper limb muscle weakness (HP:0003484)2.42624891
47Chorioretinal atrophy (HP:0000533)2.42277149
48Fragile skin (HP:0001030)2.40885006
49Type 1 muscle fiber predominance (HP:0003803)2.38380690
50Muscle fiber splitting (HP:0003555)2.37694232
51Decreased central vision (HP:0007663)2.37232339
52Inability to walk (HP:0002540)2.36330498
53Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.34159466
54Febrile seizures (HP:0002373)2.33190334
55Submucous cleft hard palate (HP:0000176)2.26708213
56Osteomalacia (HP:0002749)2.25434372
57Aortic dissection (HP:0002647)2.23158020
58Redundant skin (HP:0001582)2.21964167
59Abnormal drinking behavior (HP:0030082)2.21672326
60Polydipsia (HP:0001959)2.21672326
61Aplasia cutis congenita (HP:0001057)2.18787588
62Distal lower limb muscle weakness (HP:0009053)2.18644421
63Abnormality of the septum pellucidum (HP:0007375)2.16895940
64Hypoplasia of the iris (HP:0007676)2.15781454
65Round ear (HP:0100830)2.14367572
66Ulnar claw (HP:0001178)2.13610052
67Bladder diverticulum (HP:0000015)2.12784439
68Pendular nystagmus (HP:0012043)2.10682176
69Rib fusion (HP:0000902)2.10585979
70Neurofibrillary tangles (HP:0002185)2.08702272
71Nasolacrimal duct obstruction (HP:0000579)2.07133739
72Hypoplasia of the fovea (HP:0007750)2.06017498
73Aplasia/Hypoplasia of the fovea (HP:0008060)2.06017498
74Attenuation of retinal blood vessels (HP:0007843)2.04406210
75Prostate neoplasm (HP:0100787)2.03789305
76Prominent supraorbital ridges (HP:0000336)2.02630923
77Palpebral edema (HP:0100540)2.02576651
78Joint stiffness (HP:0001387)2.02302744
79Cystic liver disease (HP:0006706)2.00730690
80Abnormality of alanine metabolism (HP:0010916)1.99865525
81Hyperalaninemia (HP:0003348)1.99865525
82Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.99865525
83Flat cornea (HP:0007720)1.98929952
84Hypoplastic pelvis (HP:0008839)1.98916144
85Delayed gross motor development (HP:0002194)1.98837907
86Aplasia/Hypoplasia of the patella (HP:0006498)1.98694105
87Cerebellar dysplasia (HP:0007033)1.98279856
88Absent/shortened dynein arms (HP:0200106)1.97982017
89Dynein arm defect of respiratory motile cilia (HP:0012255)1.97982017
90Limited hip movement (HP:0008800)1.97762074
91Thyroid-stimulating hormone excess (HP:0002925)1.97278820
92Spinal rigidity (HP:0003306)1.97262289
93Adrenal hypoplasia (HP:0000835)1.97119810
94Morphological abnormality of the middle ear (HP:0008609)1.96819440
95Aortic valve stenosis (HP:0001650)1.96681866
96Aplasia/Hypoplasia of the tongue (HP:0010295)1.96500790
97Aplasia of the musculature (HP:0100854)1.94644463
98Synostosis involving the elbow (HP:0003938)1.93414962
99Humeroradial synostosis (HP:0003041)1.93414962
100Hypothermia (HP:0002045)1.91863394
101Mesomelia (HP:0003027)1.91837942
102Patellar aplasia (HP:0006443)1.91251510
103Polyuria (HP:0000103)1.90806813
104Hypoventilation (HP:0002791)1.90350898
105Abnormal ciliary motility (HP:0012262)1.90251580
106Progressive inability to walk (HP:0002505)1.90248688
107Lissencephaly (HP:0001339)1.89886244
108Aplasia/Hypoplasia involving the musculature (HP:0001460)1.89788388
109Narrow nasal bridge (HP:0000446)1.89665255
110Aplasia/Hypoplasia of the lens (HP:0008063)1.88688661
111Optic nerve hypoplasia (HP:0000609)1.87045007
112Occipital encephalocele (HP:0002085)1.85004415
113Ankle contracture (HP:0006466)1.84785719
114Medial flaring of the eyebrow (HP:0010747)1.84528947
115Tarsal synostosis (HP:0008368)1.84395602
116Bell-shaped thorax (HP:0001591)1.84142939
117Chronic hepatic failure (HP:0100626)1.83143420
118Abolished electroretinogram (ERG) (HP:0000550)1.82861497
119Synostosis involving bones of the feet (HP:0009140)1.82469500
120Synostosis involving bones of the lower limbs (HP:0009138)1.82469500
121Hypophosphatemic rickets (HP:0004912)1.81442135
122Severe muscular hypotonia (HP:0006829)1.81325292
123Decreased circulating renin level (HP:0003351)1.79239268
124Abnormal rod and cone electroretinograms (HP:0008323)1.78934533
125Short tibia (HP:0005736)1.78813292
126Arthropathy (HP:0003040)1.78742065
127Abnormality of incisor morphology (HP:0011063)1.78321289
128Broad ribs (HP:0000885)1.77792582
129Xerostomia (HP:0000217)1.77762007
130Furrowed tongue (HP:0000221)1.77213365
131Retinal dysplasia (HP:0007973)1.76490919
132Overgrowth (HP:0001548)1.75635616
133Wide anterior fontanel (HP:0000260)1.75297279
134Stomach cancer (HP:0012126)1.74647230
135Renal cortical cysts (HP:0000803)1.74260993
136Symphalangism affecting the phalanges of the hand (HP:0009773)1.72979511
137Ureteral duplication (HP:0000073)1.72834087
138Genetic anticipation (HP:0003743)1.72507111
139Sclerocornea (HP:0000647)1.72504808
140Abnormality of dentin (HP:0010299)1.72413846
141Focal motor seizures (HP:0011153)1.72077849
142Abnormality of the fovea (HP:0000493)1.72033071
143Bowel diverticulosis (HP:0005222)1.71917974
144Aortic aneurysm (HP:0004942)1.71675838
145Nemaline bodies (HP:0003798)1.70797551
146Oligodactyly (hands) (HP:0001180)1.69382746
147Rectal prolapse (HP:0002035)1.68524200
148Infantile muscular hypotonia (HP:0008947)1.67727910
149Broad metatarsal (HP:0001783)1.66915959
150Increased connective tissue (HP:0009025)1.66885590
151Cervical subluxation (HP:0003308)1.65522637
152Tubulointerstitial fibrosis (HP:0005576)1.65095923
153Steppage gait (HP:0003376)1.64821516
154Congenital ichthyosiform erythroderma (HP:0007431)1.63940592
155Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.63757164
156Epileptic encephalopathy (HP:0200134)1.63429808
157Flared iliac wings (HP:0002869)1.62716469
158Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.62187182
159Distal lower limb amyotrophy (HP:0008944)1.62131967
160Testicular atrophy (HP:0000029)1.61523540
161Muscle fiber inclusion bodies (HP:0100299)1.60489466
162Abnormality of the pons (HP:0007361)1.60274736
163Calf muscle hypertrophy (HP:0008981)1.60211890
164Bone cyst (HP:0012062)1.59617339
165Congenital hepatic fibrosis (HP:0002612)1.59457400
166Recurrent pneumonia (HP:0006532)1.59171304
167Conical tooth (HP:0000698)1.57883967
168Aplasia/Hypoplasia of the tibia (HP:0005772)1.56960763
169Abnormal respiratory epithelium morphology (HP:0012253)1.55761195
170Abnormal respiratory motile cilium morphology (HP:0005938)1.55761195
171Abnormality of the axillary hair (HP:0100134)1.55567244
172Abnormality of secondary sexual hair (HP:0009888)1.55567244
173Abnormality of the nasolacrimal system (HP:0000614)1.55223247

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK5.79310603
2WNK43.58172167
3FRK3.40530336
4MAP4K22.97855785
5EPHB12.72893719
6ZAK2.63020921
7STK162.15246652
8MAPKAPK52.14571342
9PINK12.13554823
10BLK2.13028849
11MAP2K71.95856652
12PKN11.94710160
13WNK31.86672908
14ACVR1B1.85406148
15INSRR1.83948409
16PIK3CG1.80191844
17STK391.78923993
18EIF2AK21.77702347
19BMPR1B1.75041130
20BMPR21.65304080
21GRK51.61896021
22TNIK1.61809171
23MAP3K141.58647375
24CLK11.52151381
25AKT31.50981772
26TGFBR11.50465255
27TAOK31.50314904
28DDR21.48296635
29CAMKK21.43179332
30MAPK131.41365762
31PAK31.41036161
32GRK71.40114256
33MAPKAPK31.37699563
34DAPK21.37645049
35BCR1.35073665
36PBK1.32069712
37STK38L1.30513047
38GRK11.30426759
39IRAK31.29554087
40YES11.27281743
41MKNK21.26513001
42MKNK11.26277293
43ADRBK21.26230834
44IRAK41.23983035
45KIT1.23879685
46CDK31.23865242
47NEK61.23788104
48PIM21.23534632
49TXK1.21349620
50MAP3K41.20835265
51IRAK11.20552010
52TIE11.17316726
53OBSCN1.17121698
54LIMK11.15670222
55OXSR11.13718458
56PLK21.13519421
57NME11.12345577
58PRKCE1.07817592
59PRPF4B1.03008991
60DYRK20.99911012
61PRKCG0.99167226
62EPHA30.97582943
63ERBB30.96411261
64MUSK0.93507602
65NTRK20.88386019
66NEK20.86925827
67TEC0.86738681
68CAMK2D0.79863092
69NTRK10.79671020
70MAP2K10.78986113
71RPS6KA50.78079108
72CDK80.76569631
73WNK10.75862101
74ABL20.74854630
75CAMK10.73972921
76LATS20.73864476
77IRAK20.73311730
78CAMK2A0.73277090
79FGR0.71693669
80MAP2K60.71046638
81CSNK1G10.70696001
82CAMK2B0.67674346
83TNK20.62789375
84CSK0.62399317
85GRK60.61915264
86IKBKB0.61098913
87ROCK20.61027136
88NEK90.60765719
89SIK30.60578502
90PRKG10.59332622
91EPHB20.59137773
92STK30.59129534
93PAK20.59057727
94FLT30.58774372
95NLK0.58704498
96PHKG10.58169358
97PHKG20.58169358
98RPS6KA60.56768142
99TLK10.56537187
100SGK2230.56481477
101SGK4940.56481477
102PRKD20.55184034
103TRPM70.55171481
104PRKCQ0.54064757
105PAK60.53708088
106MAPK150.53350250
107FER0.52823653
108MARK20.52790695
109PDGFRB0.52326804
110PRKD30.51535958
111DYRK1A0.51514310
112CSNK1G20.50717617
113PRKCI0.49901742
114VRK10.47351073
115TGFBR20.47161201
116PNCK0.46366832
117MAP3K60.45576830
118RPS6KA40.45216133
119PRKACA0.45150984
120TSSK60.44805804
121TRIM280.44231377
122EPHA40.43946427
123BCKDK0.43699377
124CCNB10.41611995
125MAPK70.40754686
126MARK10.40708233
127PIK3CA0.39950848
128PRKD10.39493816
129SGK20.38906103
130MAP2K20.38675532
131PRKCH0.38074519
132STK380.38062662
133NTRK30.37835473
134CAMK2G0.37298896
135MYLK0.37213065
136MAP3K70.36976845
137ROCK10.36573339
138CSNK1G30.36058517
139MAP2K40.35743897
140PRKAA20.34441059
141BRD40.34400424
142TAF10.34369882
143CSNK1A10.34317895
144LATS10.34306262
145ADRBK10.33831186
146NUAK10.32711759
147PTK2B0.32406329
148UHMK10.29950625
149MST40.28662730

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.61589279
2Phototransduction_Homo sapiens_hsa047442.50261172
3Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.46624932
4Steroid biosynthesis_Homo sapiens_hsa001002.34899561
5Ether lipid metabolism_Homo sapiens_hsa005652.32380402
6Selenocompound metabolism_Homo sapiens_hsa004502.14771769
7Nitrogen metabolism_Homo sapiens_hsa009102.12668666
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.05780989
9Arachidonic acid metabolism_Homo sapiens_hsa005902.03947897
10Nicotine addiction_Homo sapiens_hsa050332.03022305
11Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.01739076
12ECM-receptor interaction_Homo sapiens_hsa045121.99573889
13Autoimmune thyroid disease_Homo sapiens_hsa053201.97504369
14Taste transduction_Homo sapiens_hsa047421.95586086
15Fatty acid elongation_Homo sapiens_hsa000621.95062974
16Vitamin B6 metabolism_Homo sapiens_hsa007501.85265739
17Linoleic acid metabolism_Homo sapiens_hsa005911.73876692
18Sphingolipid metabolism_Homo sapiens_hsa006001.70017503
19alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.68906481
20Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.68491361
21Tryptophan metabolism_Homo sapiens_hsa003801.63834457
22Maturity onset diabetes of the young_Homo sapiens_hsa049501.62541241
23Serotonergic synapse_Homo sapiens_hsa047261.60676218
24Butanoate metabolism_Homo sapiens_hsa006501.55150348
25Other glycan degradation_Homo sapiens_hsa005111.52137786
26Morphine addiction_Homo sapiens_hsa050321.48432308
27Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.43636133
28Rheumatoid arthritis_Homo sapiens_hsa053231.38224743
29Axon guidance_Homo sapiens_hsa043601.34623084
30Caffeine metabolism_Homo sapiens_hsa002321.34432806
31Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.34231330
32Fanconi anemia pathway_Homo sapiens_hsa034601.33446424
33Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.31312705
34Primary bile acid biosynthesis_Homo sapiens_hsa001201.28441783
35Malaria_Homo sapiens_hsa051441.26275613
36Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.24034177
37Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.23646018
38Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.23559887
39Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.21992291
40Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.21753363
41Glycosaminoglycan degradation_Homo sapiens_hsa005311.20243912
42Peroxisome_Homo sapiens_hsa041461.17659421
43Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.14869053
44Oxidative phosphorylation_Homo sapiens_hsa001901.14013083
45Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.12803764
46Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.12772146
47Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.11939875
48Insulin secretion_Homo sapiens_hsa049111.10668988
49Hedgehog signaling pathway_Homo sapiens_hsa043401.10622153
50ABC transporters_Homo sapiens_hsa020101.09750957
51Chemical carcinogenesis_Homo sapiens_hsa052041.09035495
52Glutamatergic synapse_Homo sapiens_hsa047241.08316491
53Protein digestion and absorption_Homo sapiens_hsa049741.08269080
54Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.07966567
55Phagosome_Homo sapiens_hsa041451.05393286
56Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.04721228
57Calcium signaling pathway_Homo sapiens_hsa040201.01230764
58Protein export_Homo sapiens_hsa030601.01154298
59Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.99406263
60Regulation of autophagy_Homo sapiens_hsa041400.97145604
61Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.95297903
62Dilated cardiomyopathy_Homo sapiens_hsa054140.94933575
63Propanoate metabolism_Homo sapiens_hsa006400.94632873
64Glycerolipid metabolism_Homo sapiens_hsa005610.94109256
65Circadian entrainment_Homo sapiens_hsa047130.93293172
66Ovarian steroidogenesis_Homo sapiens_hsa049130.92382843
67Tyrosine metabolism_Homo sapiens_hsa003500.90880814
68RNA polymerase_Homo sapiens_hsa030200.90117027
69Alzheimers disease_Homo sapiens_hsa050100.87874172
70Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.87086351
71Ras signaling pathway_Homo sapiens_hsa040140.86760307
72Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.85428025
73Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.84654121
74GABAergic synapse_Homo sapiens_hsa047270.83254447
75Basal transcription factors_Homo sapiens_hsa030220.82747989
76Cyanoamino acid metabolism_Homo sapiens_hsa004600.82583876
77Fat digestion and absorption_Homo sapiens_hsa049750.82498560
78Long-term depression_Homo sapiens_hsa047300.81597057
79PI3K-Akt signaling pathway_Homo sapiens_hsa041510.81115522
80Graft-versus-host disease_Homo sapiens_hsa053320.79279735
81Melanoma_Homo sapiens_hsa052180.79146653
82Vascular smooth muscle contraction_Homo sapiens_hsa042700.77725161
83Hematopoietic cell lineage_Homo sapiens_hsa046400.75342160
84NF-kappa B signaling pathway_Homo sapiens_hsa040640.70820008
85Sulfur relay system_Homo sapiens_hsa041220.70082058
86Wnt signaling pathway_Homo sapiens_hsa043100.69606540
87Circadian rhythm_Homo sapiens_hsa047100.66870951
88Homologous recombination_Homo sapiens_hsa034400.65273140
89Intestinal immune network for IgA production_Homo sapiens_hsa046720.64570247
90Steroid hormone biosynthesis_Homo sapiens_hsa001400.63464242
91Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.62171283
92Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.60946476
93TGF-beta signaling pathway_Homo sapiens_hsa043500.60052354
94Focal adhesion_Homo sapiens_hsa045100.59990935
95One carbon pool by folate_Homo sapiens_hsa006700.59332165
96Fatty acid degradation_Homo sapiens_hsa000710.59019034
97Allograft rejection_Homo sapiens_hsa053300.58228080
98Olfactory transduction_Homo sapiens_hsa047400.57956168
99Oxytocin signaling pathway_Homo sapiens_hsa049210.56992450
100Huntingtons disease_Homo sapiens_hsa050160.56607793
101African trypanosomiasis_Homo sapiens_hsa051430.55672251
102SNARE interactions in vesicular transport_Homo sapiens_hsa041300.55394075
103Salivary secretion_Homo sapiens_hsa049700.55254813
104Retinol metabolism_Homo sapiens_hsa008300.52709572
105Aldosterone synthesis and secretion_Homo sapiens_hsa049250.52027761
106Amphetamine addiction_Homo sapiens_hsa050310.51477135
107cGMP-PKG signaling pathway_Homo sapiens_hsa040220.51368272
108Dopaminergic synapse_Homo sapiens_hsa047280.50885705
109Metabolic pathways_Homo sapiens_hsa011000.50582217
110Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.50288407
111Collecting duct acid secretion_Homo sapiens_hsa049660.49399677
112Basal cell carcinoma_Homo sapiens_hsa052170.46567763
113PPAR signaling pathway_Homo sapiens_hsa033200.46501797
114Renin secretion_Homo sapiens_hsa049240.46205076
115Cholinergic synapse_Homo sapiens_hsa047250.46099148
116Chemokine signaling pathway_Homo sapiens_hsa040620.45698435
117Sulfur metabolism_Homo sapiens_hsa009200.45125120
118Parkinsons disease_Homo sapiens_hsa050120.44481515
119cAMP signaling pathway_Homo sapiens_hsa040240.43799992
120Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.43522773
121Hippo signaling pathway_Homo sapiens_hsa043900.42260121
122Purine metabolism_Homo sapiens_hsa002300.41998828
123Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.41504659
124MAPK signaling pathway_Homo sapiens_hsa040100.41422781
125Mineral absorption_Homo sapiens_hsa049780.41074775
126Histidine metabolism_Homo sapiens_hsa003400.40765588
127beta-Alanine metabolism_Homo sapiens_hsa004100.40604124
128Regulation of actin cytoskeleton_Homo sapiens_hsa048100.40184284
129Renin-angiotensin system_Homo sapiens_hsa046140.39037022
130Toll-like receptor signaling pathway_Homo sapiens_hsa046200.38589230
131Pathways in cancer_Homo sapiens_hsa052000.38491386
132TNF signaling pathway_Homo sapiens_hsa046680.36962659
133Cocaine addiction_Homo sapiens_hsa050300.36861692
134Cardiac muscle contraction_Homo sapiens_hsa042600.35585063
135Vitamin digestion and absorption_Homo sapiens_hsa049770.35050166
136NOD-like receptor signaling pathway_Homo sapiens_hsa046210.33961927
137ErbB signaling pathway_Homo sapiens_hsa040120.32951355
138Asthma_Homo sapiens_hsa053100.32776156
139Prostate cancer_Homo sapiens_hsa052150.32194036
140Choline metabolism in cancer_Homo sapiens_hsa052310.32178679
141Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.31768729

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