LRRTM1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1vocalization behavior (GO:0071625)5.94543596
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.83312565
3synaptic vesicle exocytosis (GO:0016079)5.78703150
4neuron cell-cell adhesion (GO:0007158)5.53315358
5regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.42816239
6positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.38638903
7positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.28666399
8locomotory exploration behavior (GO:0035641)5.20384234
9synaptic vesicle maturation (GO:0016188)5.18520640
10ionotropic glutamate receptor signaling pathway (GO:0035235)5.02866822
11regulation of glutamate receptor signaling pathway (GO:1900449)4.97140893
12* protein localization to synapse (GO:0035418)4.90534546
13gamma-aminobutyric acid signaling pathway (GO:0007214)4.80747899
14glutamate secretion (GO:0014047)4.73961113
15regulation of synaptic vesicle exocytosis (GO:2000300)4.72204868
16glutamate receptor signaling pathway (GO:0007215)4.71132925
17* exploration behavior (GO:0035640)4.49600938
18positive regulation of synapse maturation (GO:0090129)4.48160896
19regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.45486693
20synaptic transmission, glutamatergic (GO:0035249)4.35218265
21regulation of long-term neuronal synaptic plasticity (GO:0048169)4.33188238
22regulation of neuronal synaptic plasticity (GO:0048168)4.31077389
23regulation of synaptic vesicle transport (GO:1902803)4.26204167
24neurotransmitter-gated ion channel clustering (GO:0072578)4.23801382
25neuron recognition (GO:0008038)4.23500984
26synaptic vesicle docking involved in exocytosis (GO:0016081)4.19592461
27neuron-neuron synaptic transmission (GO:0007270)4.19558842
28regulation of synapse structural plasticity (GO:0051823)4.12251005
29establishment of mitochondrion localization (GO:0051654)4.08076644
30neurotransmitter secretion (GO:0007269)4.07964601
31synaptic vesicle endocytosis (GO:0048488)4.02904376
32postsynaptic membrane organization (GO:0001941)4.02032362
33neuronal action potential propagation (GO:0019227)3.99382869
34axonal fasciculation (GO:0007413)3.92509230
35presynaptic membrane assembly (GO:0097105)3.88775099
36regulation of excitatory postsynaptic membrane potential (GO:0060079)3.88273526
37dendritic spine morphogenesis (GO:0060997)3.83230632
38G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.78857969
39cellular potassium ion homeostasis (GO:0030007)3.77582334
40regulation of postsynaptic membrane potential (GO:0060078)3.71487388
41long-term memory (GO:0007616)3.69825759
42response to histamine (GO:0034776)3.67730782
43layer formation in cerebral cortex (GO:0021819)3.66933288
44behavioral fear response (GO:0001662)3.66807412
45behavioral defense response (GO:0002209)3.66807412
46positive regulation of membrane potential (GO:0045838)3.65508155
47regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.65148350
48presynaptic membrane organization (GO:0097090)3.60970202
49regulation of synaptic transmission, glutamatergic (GO:0051966)3.60499732
50transmission of nerve impulse (GO:0019226)3.58419241
51* long-term synaptic potentiation (GO:0060291)3.56675035
52innervation (GO:0060384)3.56416654
53regulation of synapse maturation (GO:0090128)3.55205572
54* regulation of synaptic plasticity (GO:0048167)3.54366930
55proline transport (GO:0015824)3.52902104
56regulation of dendritic spine morphogenesis (GO:0061001)3.52152381
57negative regulation of dendrite morphogenesis (GO:0050774)3.51805126
58negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.50443507
59mechanosensory behavior (GO:0007638)3.49254423
60positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.45811842
61response to parathyroid hormone (GO:0071107)3.44017955
62cerebellar granule cell differentiation (GO:0021707)3.43808095
63sodium ion export (GO:0071436)3.39827247
64negative regulation of synaptic transmission, GABAergic (GO:0032229)3.39389994
65fear response (GO:0042596)3.39164828
66neurotransmitter transport (GO:0006836)3.37993147
67regulation of neurotransmitter secretion (GO:0046928)3.36975378
68regulation of vesicle fusion (GO:0031338)3.35330556
69synapse assembly (GO:0007416)3.33232588
70learning (GO:0007612)3.30571150
71gamma-aminobutyric acid transport (GO:0015812)3.29839869
72pyrimidine nucleobase catabolic process (GO:0006208)3.29061591
73positive regulation of synaptic transmission, GABAergic (GO:0032230)3.28904305
74cell migration in hindbrain (GO:0021535)3.27504825
75establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.24637965
76mitochondrion transport along microtubule (GO:0047497)3.24637965
77cell communication by electrical coupling (GO:0010644)3.23873385
78cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.22106772
79membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.20603470
80positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.18872988
81G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.17280383
82neuromuscular process controlling posture (GO:0050884)3.13630900
83regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.12841391
84negative regulation of dendrite development (GO:2000171)3.12434157
85membrane depolarization (GO:0051899)3.11371651
86positive regulation of dendritic spine morphogenesis (GO:0061003)3.11254427
87positive regulation of dendritic spine development (GO:0060999)3.11127845
88dendrite morphogenesis (GO:0048813)3.10477595
89synaptic transmission (GO:0007268)3.10404018
90axon ensheathment in central nervous system (GO:0032291)3.09728959
91central nervous system myelination (GO:0022010)3.09728959
92detection of calcium ion (GO:0005513)3.09079271
93auditory behavior (GO:0031223)3.08998076
94positive regulation of neurotransmitter secretion (GO:0001956)3.08666380
95regulation of neurotransmitter levels (GO:0001505)3.08604249
96righting reflex (GO:0060013)3.08432291
97establishment of synaptic vesicle localization (GO:0097480)3.08093936
98synaptic vesicle transport (GO:0048489)3.08093936
99regulation of voltage-gated calcium channel activity (GO:1901385)3.07526564
100regulation of dendritic spine development (GO:0060998)3.06055472
101cerebellar Purkinje cell differentiation (GO:0021702)3.04351438
102regulation of neurotransmitter transport (GO:0051588)3.04343430
103positive regulation of synapse assembly (GO:0051965)3.03578576
104membrane hyperpolarization (GO:0060081)3.03290847
105activation of protein kinase A activity (GO:0034199)3.02342184
106response to pheromone (GO:0019236)3.00580106
107neuronal ion channel clustering (GO:0045161)2.99980124
108regulation of glutamate secretion (GO:0014048)2.99352856
109neuromuscular process controlling balance (GO:0050885)2.99297500
110dendritic spine organization (GO:0097061)2.98541163
111central nervous system projection neuron axonogenesis (GO:0021952)2.98234193
112behavioral response to cocaine (GO:0048148)2.98203467
113membrane depolarization during action potential (GO:0086010)2.98009841
114* regulation of synaptic transmission (GO:0050804)2.97616253
115startle response (GO:0001964)2.96548198
116mating behavior (GO:0007617)2.96492326
117prepulse inhibition (GO:0060134)2.95522926
118L-amino acid import (GO:0043092)2.95392769
119regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.94533764
120response to auditory stimulus (GO:0010996)2.93858422
121neuromuscular synaptic transmission (GO:0007274)2.92967074
122positive regulation of neurotransmitter transport (GO:0051590)2.89320699
123positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.88226511

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.87554934
2GBX2_23144817_ChIP-Seq_PC3_Human3.90626585
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.21276563
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.18642741
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.15739246
6REST_21632747_ChIP-Seq_MESCs_Mouse2.80313750
7* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.73887600
8* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.73887600
9* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.71706029
10* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.71301322
11* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.68787114
12* EZH2_27304074_Chip-Seq_ESCs_Mouse2.68691844
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.53021229
14* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.52004282
15* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.51460350
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.47895267
17* EED_16625203_ChIP-ChIP_MESCs_Mouse2.47707293
18DROSHA_22980978_ChIP-Seq_HELA_Human2.38771094
19RARB_27405468_Chip-Seq_BRAIN_Mouse2.37405394
20* EZH2_27294783_Chip-Seq_ESCs_Mouse2.36336822
21CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.30388426
22* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.27236208
23REST_18959480_ChIP-ChIP_MESCs_Mouse2.24485370
24* RNF2_27304074_Chip-Seq_ESCs_Mouse2.22014167
25NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.19830013
26IKZF1_21737484_ChIP-ChIP_HCT116_Human2.16972344
27CTBP2_25329375_ChIP-Seq_LNCAP_Human2.14151085
28ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.14111126
29CTBP1_25329375_ChIP-Seq_LNCAP_Human2.04442602
30AR_21572438_ChIP-Seq_LNCaP_Human2.00360054
31TAF15_26573619_Chip-Seq_HEK293_Human1.90808757
32SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.70083740
33* SMAD4_21799915_ChIP-Seq_A2780_Human1.69618140
34ZFP57_27257070_Chip-Seq_ESCs_Mouse1.67185187
35PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.62651701
36SMAD_19615063_ChIP-ChIP_OVARY_Human1.60111176
37MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.59469390
38THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.56050282
39* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.55330634
40* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.54485756
41EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.54471683
42GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.52537674
43* P300_19829295_ChIP-Seq_ESCs_Human1.50995439
44IGF1R_20145208_ChIP-Seq_DFB_Human1.50800162
45ZNF274_21170338_ChIP-Seq_K562_Hela1.50014162
46CBX2_27304074_Chip-Seq_ESCs_Mouse1.49297458
47* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.48053124
48* SMAD3_21741376_ChIP-Seq_EPCs_Human1.43096240
49TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.39189420
50RING1B_27294783_Chip-Seq_ESCs_Mouse1.36625061
51PIAS1_25552417_ChIP-Seq_VCAP_Human1.35942463
52SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.35623386
53AR_25329375_ChIP-Seq_VCAP_Human1.33800645
54SOX2_21211035_ChIP-Seq_LN229_Gbm1.33531493
55* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.32748772
56ERG_21242973_ChIP-ChIP_JURKAT_Human1.30489665
57* RNF2_27304074_Chip-Seq_NSC_Mouse1.28919233
58HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.27423121
59P53_22127205_ChIP-Seq_FIBROBLAST_Human1.26561843
60POU3F2_20337985_ChIP-ChIP_501MEL_Human1.25896173
61NR3C1_23031785_ChIP-Seq_PC12_Mouse1.25797009
62FUS_26573619_Chip-Seq_HEK293_Human1.25174221
63* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22632933
64* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20177980
65* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.20041553
66RING1B_27294783_Chip-Seq_NPCs_Mouse1.18693190
67* AR_19668381_ChIP-Seq_PC3_Human1.18365996
68STAT3_23295773_ChIP-Seq_U87_Human1.14650608
69RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.13255358
70PRDM14_20953172_ChIP-Seq_ESCs_Human1.10671997
71TCF4_23295773_ChIP-Seq_U87_Human1.07552932
72* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.07370493
73TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06922990
74OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.06696484
75YAP1_20516196_ChIP-Seq_MESCs_Mouse1.05831511
76ARNT_22903824_ChIP-Seq_MCF-7_Human1.05731078
77ZFP281_18757296_ChIP-ChIP_E14_Mouse1.03906522
78VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.02255544
79CDX2_19796622_ChIP-Seq_MESCs_Mouse1.01605310
80* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.01345012
81* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.00189078
82DNAJC2_21179169_ChIP-ChIP_NT2_Human0.99944780
83CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.99826946
84WT1_25993318_ChIP-Seq_PODOCYTE_Human0.98706485
85AHR_22903824_ChIP-Seq_MCF-7_Human0.98606999
86CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98374547
87* JUN_21703547_ChIP-Seq_K562_Human0.97773718
88* RUNX2_22187159_ChIP-Seq_PCA_Human0.97188328
89CBP_20019798_ChIP-Seq_JUKART_Human0.95113804
90IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.95113804
91NR3C1_21868756_ChIP-Seq_MCF10A_Human0.93677990
92LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93581999
93TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.93548453
94SMAD4_21741376_ChIP-Seq_HESCs_Human0.93383065
95ER_23166858_ChIP-Seq_MCF-7_Human0.92954041
96FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.92641961
97TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.92573704
98PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.92100089
99RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.92058365
100VDR_22108803_ChIP-Seq_LS180_Human0.91731341
101* SMAD3_21741376_ChIP-Seq_ESCs_Human0.91461708
102ZNF217_24962896_ChIP-Seq_MCF-7_Human0.91265097
103NANOG_18555785_Chip-Seq_ESCs_Mouse0.89961908
104KDM2B_26808549_Chip-Seq_REH_Human0.89763240
105* POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.89531959
106* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89531959
107TP53_18474530_ChIP-ChIP_U2OS_Human0.89134779
108SMAD3_21741376_ChIP-Seq_HESCs_Human0.86920801
109SOX9_26525672_Chip-Seq_HEART_Mouse0.86840077
110TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.86837098
111GATA1_26923725_Chip-Seq_HPCs_Mouse0.86030669
112* TP53_20018659_ChIP-ChIP_R1E_Mouse0.85935207
113KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.85458266
114* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.84741655
115MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.84332550
116* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.83696065
117CTCF_27219007_Chip-Seq_Bcells_Human0.83299126

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.31418054
2MP0003880_abnormal_central_pattern5.42561009
3MP0003635_abnormal_synaptic_transmissio4.16322587
4MP0009745_abnormal_behavioral_response3.56138920
5MP0002063_abnormal_learning/memory/cond3.48574789
6MP0004270_analgesia3.44236487
7MP0002064_seizures3.20110254
8MP0001968_abnormal_touch/_nociception3.04429569
9MP0002572_abnormal_emotion/affect_behav2.88845807
10MP0009046_muscle_twitch2.76533347
11MP0001486_abnormal_startle_reflex2.70357781
12MP0005423_abnormal_somatic_nervous2.67445605
13MP0002736_abnormal_nociception_after2.59851810
14MP0003123_paternal_imprinting2.54388154
15MP0002272_abnormal_nervous_system2.50910329
16MP0002822_catalepsy2.50082805
17MP0002734_abnormal_mechanical_nocicepti2.41862212
18MP0008877_abnormal_DNA_methylation2.31152523
19MP0000569_abnormal_digit_pigmentation2.27253558
20MP0001501_abnormal_sleep_pattern2.24577215
21MP0001440_abnormal_grooming_behavior2.22729835
22MP0002735_abnormal_chemical_nociception2.19018748
23MP0000778_abnormal_nervous_system2.09080401
24MP0009780_abnormal_chondrocyte_physiolo2.06505964
25MP0001984_abnormal_olfaction2.01724436
26MP0002067_abnormal_sensory_capabilities1.99833605
27MP0003121_genomic_imprinting1.99238507
28MP0003329_amyloid_beta_deposits1.97383152
29MP0006276_abnormal_autonomic_nervous1.91991301
30MP0002733_abnormal_thermal_nociception1.91083767
31MP0002184_abnormal_innervation1.88294902
32MP0001970_abnormal_pain_threshold1.83360076
33MP0002557_abnormal_social/conspecific_i1.81709411
34MP0002638_abnormal_pupillary_reflex1.64388739
35MP0004811_abnormal_neuron_physiology1.62250520
36MP0001529_abnormal_vocalization1.59836446
37MP0004924_abnormal_behavior1.59150206
38MP0005386_behavior/neurological_phenoty1.59150206
39MP0008569_lethality_at_weaning1.57669370
40MP0002102_abnormal_ear_morphology1.56565031
41MP0004858_abnormal_nervous_system1.56121209
42MP0001502_abnormal_circadian_rhythm1.53910572
43MP0000955_abnormal_spinal_cord1.53532915
44MP0002882_abnormal_neuron_morphology1.48529172
45MP0005646_abnormal_pituitary_gland1.48031649
46MP0005551_abnormal_eye_electrophysiolog1.42948412
47MP0002066_abnormal_motor_capabilities/c1.41593096
48MP0002909_abnormal_adrenal_gland1.39160296
49MP0003879_abnormal_hair_cell1.37134756
50MP0004142_abnormal_muscle_tone1.34325977
51MP0003787_abnormal_imprinting1.29658666
52MP0004885_abnormal_endolymph1.27825556
53MP0005394_taste/olfaction_phenotype1.26037341
54MP0005499_abnormal_olfactory_system1.26037341
55MP0001188_hyperpigmentation1.25278872
56MP0003122_maternal_imprinting1.24702933
57MP0005645_abnormal_hypothalamus_physiol1.21370133
58MP0002152_abnormal_brain_morphology1.20456853
59MP0001905_abnormal_dopamine_level1.19892232
60MP0000631_abnormal_neuroendocrine_gland1.16132048
61MP0000537_abnormal_urethra_morphology1.11899934
62MP0003633_abnormal_nervous_system1.11646634
63MP0006292_abnormal_olfactory_placode1.11448376
64MP0002069_abnormal_eating/drinking_beha1.10666036
65MP0000751_myopathy1.08443088
66MP0004215_abnormal_myocardial_fiber1.06589987
67MP0004145_abnormal_muscle_electrophysio1.00823821
68MP0003631_nervous_system_phenotype0.99785563
69MP0002090_abnormal_vision0.99183848
70MP0003137_abnormal_impulse_conducting0.96913635
71MP0003690_abnormal_glial_cell0.95523920
72MP0002229_neurodegeneration0.89879495
73MP0003119_abnormal_digestive_system0.89875429
74MP0002752_abnormal_somatic_nervous0.89740235
75MP0002876_abnormal_thyroid_physiology0.89517842
76MP0001485_abnormal_pinna_reflex0.89437984
77MP0000604_amyloidosis0.88487504
78MP0003634_abnormal_glial_cell0.88194560
79MP0004742_abnormal_vestibular_system0.87479981
80MP0008995_early_reproductive_senescence0.85453024
81MP0010386_abnormal_urinary_bladder0.85292488
82MP0002837_dystrophic_cardiac_calcinosis0.84319497
83MP0001963_abnormal_hearing_physiology0.83176132
84MP0003011_delayed_dark_adaptation0.82750475
85MP0004085_abnormal_heartbeat0.79287967
86MP0002751_abnormal_autonomic_nervous0.78260506
87MP0008872_abnormal_physiological_respon0.78151403
88MP0000566_synostosis0.78052038
89MP0003567_abnormal_fetal_cardiomyocyte0.77975176
90MP0002234_abnormal_pharynx_morphology0.76244763
91MP0000639_abnormal_adrenal_gland0.76195406
92MP0003890_abnormal_embryonic-extraembry0.75377438
93MP0008789_abnormal_olfactory_epithelium0.74702537
94MP0003632_abnormal_nervous_system0.72240154
95MP0002653_abnormal_ependyma_morphology0.71584872
96MP0008874_decreased_physiological_sensi0.71267528
97MP0005535_abnormal_body_temperature0.70103876
98MP0001177_atelectasis0.67825903
99MP0006072_abnormal_retinal_apoptosis0.67644452
100MP0004233_abnormal_muscle_weight0.67296710
101MP0003861_abnormal_nervous_system0.65646755
102MP0003136_yellow_coat_color0.65619779
103MP0000920_abnormal_myelination0.65113588
104MP0005409_darkened_coat_color0.63845085
105MP0002249_abnormal_larynx_morphology0.62741681
106MP0000026_abnormal_inner_ear0.62551679
107MP0003075_altered_response_to0.61203261
108MP0003183_abnormal_peptide_metabolism0.60527395
109MP0001664_abnormal_digestion0.60297339
110MP0003938_abnormal_ear_development0.60268554
111MP0000013_abnormal_adipose_tissue0.59574792
112MP0005195_abnormal_posterior_eye0.58076606
113MP0005595_abnormal_vascular_smooth0.58068380
114MP0001943_abnormal_respiration0.57594836
115MP0008961_abnormal_basal_metabolism0.57384674
116MP0005171_absent_coat_pigmentation0.56744927
117MP0004133_heterotaxia0.56308102
118MP0005253_abnormal_eye_physiology0.56237751
119MP0010769_abnormal_survival0.55951375
120MP0000049_abnormal_middle_ear0.55709593
121MP0010770_preweaning_lethality0.55495381
122MP0002082_postnatal_lethality0.55495381
123MP0004484_altered_response_of0.55138585
124MP0010768_mortality/aging0.54694965
125MP0000516_abnormal_urinary_system0.52543938

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.77874039
2Myokymia (HP:0002411)6.60196234
3Focal seizures (HP:0007359)5.59857898
4Epileptic encephalopathy (HP:0200134)5.49484818
5Visual hallucinations (HP:0002367)5.27598468
6Febrile seizures (HP:0002373)5.11596019
7Atonic seizures (HP:0010819)4.87721523
8Progressive cerebellar ataxia (HP:0002073)4.44976914
9Absence seizures (HP:0002121)4.31386918
10Dialeptic seizures (HP:0011146)4.00393617
11Hyperventilation (HP:0002883)3.83419108
12Generalized tonic-clonic seizures (HP:0002069)3.66834864
13Mutism (HP:0002300)3.55881051
14Action tremor (HP:0002345)3.52025056
15Broad-based gait (HP:0002136)3.46591414
16Supranuclear gaze palsy (HP:0000605)3.45177406
17Ankle clonus (HP:0011448)3.41929029
18Drooling (HP:0002307)3.39336023
19Excessive salivation (HP:0003781)3.39336023
20Dysdiadochokinesis (HP:0002075)3.34567041
21Cerebral inclusion bodies (HP:0100314)3.33060984
22Neurofibrillary tangles (HP:0002185)3.25118786
23Depression (HP:0000716)3.14141638
24Amblyopia (HP:0000646)3.11673616
25Poor eye contact (HP:0000817)3.11598607
26Impaired vibration sensation in the lower limbs (HP:0002166)3.06933924
27Dysmetria (HP:0001310)3.04556020
28Degeneration of the lateral corticospinal tracts (HP:0002314)3.03565946
29Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.03565946
30Split foot (HP:0001839)2.98999652
31Abnormal eating behavior (HP:0100738)2.94101318
32Anxiety (HP:0000739)2.91751630
33Abnormality of the labia minora (HP:0012880)2.91733567
34Abnormal social behavior (HP:0012433)2.90182907
35Impaired social interactions (HP:0000735)2.90182907
36Gaze-evoked nystagmus (HP:0000640)2.88057419
37Urinary bladder sphincter dysfunction (HP:0002839)2.76219373
38Truncal ataxia (HP:0002078)2.72347295
39Postural instability (HP:0002172)2.71777914
40Epileptiform EEG discharges (HP:0011182)2.70520901
41Hemiparesis (HP:0001269)2.65065695
42Fetal akinesia sequence (HP:0001989)2.56555320
43Polyphagia (HP:0002591)2.55925747
44EEG with generalized epileptiform discharges (HP:0011198)2.51317190
45Septo-optic dysplasia (HP:0100842)2.46801115
46Absent speech (HP:0001344)2.43042951
47Gait imbalance (HP:0002141)2.42911129
48Progressive inability to walk (HP:0002505)2.41931718
49Torticollis (HP:0000473)2.39793757
50Sleep apnea (HP:0010535)2.38962766
51Genetic anticipation (HP:0003743)2.38133043
52Cerebral hypomyelination (HP:0006808)2.37773436
53Akinesia (HP:0002304)2.37280325
54Morphological abnormality of the pyramidal tract (HP:0002062)2.37254094
55Spastic gait (HP:0002064)2.35403299
56Abnormality of the lower motor neuron (HP:0002366)2.35070189
57Scanning speech (HP:0002168)2.34916627
58Delusions (HP:0000746)2.33966548
59Hypsarrhythmia (HP:0002521)2.32958560
60Urinary urgency (HP:0000012)2.32251171
61Failure to thrive in infancy (HP:0001531)2.32018251
62Bradykinesia (HP:0002067)2.30708178
63Hemiplegia (HP:0002301)2.26131013
64Abnormality of salivation (HP:0100755)2.24734816
65Impaired smooth pursuit (HP:0007772)2.24705286
66Inability to walk (HP:0002540)2.24365869
67Focal dystonia (HP:0004373)2.24069073
68Oligodactyly (hands) (HP:0001180)2.23503588
69Stereotypic behavior (HP:0000733)2.23161560
70Abnormality of binocular vision (HP:0011514)2.20543622
71Diplopia (HP:0000651)2.20543622
72Abnormality of the corticospinal tract (HP:0002492)2.17923691
73Lower limb muscle weakness (HP:0007340)2.08411575
74Insidious onset (HP:0003587)2.05486742
75Termporal pattern (HP:0011008)2.05486742
76Generalized myoclonic seizures (HP:0002123)2.03882824
77Central scotoma (HP:0000603)2.03381481
78Craniofacial dystonia (HP:0012179)2.00021738
79Incomplete penetrance (HP:0003829)1.99670107
80Spastic tetraplegia (HP:0002510)1.99190129
81Congenital primary aphakia (HP:0007707)1.97122925
82Impaired vibratory sensation (HP:0002495)1.97012030
83Protruding tongue (HP:0010808)1.96767282
84Unsteady gait (HP:0002317)1.96359177
85Retinal dysplasia (HP:0007973)1.95130572
86Intention tremor (HP:0002080)1.94205788
87Specific learning disability (HP:0001328)1.94034020
88Pendular nystagmus (HP:0012043)1.93795049
89Megalencephaly (HP:0001355)1.92703327
90Abnormality of ocular smooth pursuit (HP:0000617)1.91743330
91Hand muscle atrophy (HP:0009130)1.91284589
92Congenital stationary night blindness (HP:0007642)1.90873566
93Poor suck (HP:0002033)1.90418591
94Pheochromocytoma (HP:0002666)1.89378652
95Atrophy/Degeneration involving motor neurons (HP:0007373)1.89378576
96Labial hypoplasia (HP:0000066)1.89291248
97Status epilepticus (HP:0002133)1.88984035
98Medial flaring of the eyebrow (HP:0010747)1.85533750
99Amyotrophic lateral sclerosis (HP:0007354)1.85201241
100Nephrogenic diabetes insipidus (HP:0009806)1.81889664
101Limb dystonia (HP:0002451)1.81417726
102Papilledema (HP:0001085)1.80835300
103True hermaphroditism (HP:0010459)1.80437557
104Esotropia (HP:0000565)1.80229581
105Blue irides (HP:0000635)1.80185528
106Neuronal loss in central nervous system (HP:0002529)1.79968682
107Ventricular fibrillation (HP:0001663)1.79697286
108Clonus (HP:0002169)1.79693908
109Psychosis (HP:0000709)1.78369589
110Aplasia/Hypoplasia of the brainstem (HP:0007362)1.78275828
111Hypoplasia of the brainstem (HP:0002365)1.78275828
112Annular pancreas (HP:0001734)1.76869359
113Vaginal atresia (HP:0000148)1.76137009
114Optic nerve hypoplasia (HP:0000609)1.74864448
115Tetraplegia (HP:0002445)1.73119813
116Abnormality of the vocal cords (HP:0008777)1.72192272
117Abnormal hair whorl (HP:0010721)1.71337821
118CNS hypomyelination (HP:0003429)1.71292342
119Hypoventilation (HP:0002791)1.69730913
120Hypoplasia of the corpus callosum (HP:0002079)1.69632369
121Gonadal dysgenesis (HP:0000133)1.69115343
122Narrow nasal bridge (HP:0000446)1.69054696
123Obstructive sleep apnea (HP:0002870)1.69044851
124Autism (HP:0000717)1.68765539
125Genital tract atresia (HP:0001827)1.67879289
126Agitation (HP:0000713)1.67843041

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.86229403
2NTRK34.55813624
3MAP3K93.27546840
4MARK13.22237484
5CASK3.05476234
6MAP3K42.69550536
7MINK12.61410680
8MAP2K72.42499167
9PRPF4B2.42220836
10MAP3K122.40187756
11RIPK42.27609946
12DAPK22.13144919
13PAK62.10866448
14KSR11.99073522
15NTRK21.94966946
16TNIK1.94369152
17KSR21.91440453
18PLK21.78398285
19MAP2K41.71580886
20ARAF1.64083008
21MAPK131.62319728
22DAPK11.55348758
23PNCK1.51914423
24CDK51.48728725
25NTRK11.47390483
26GRK51.39478744
27PRKCG1.39106250
28SIK21.37089784
29PHKG21.34097814
30PHKG11.34097814
31FES1.30822331
32PRKD31.29202295
33CAMKK11.21696876
34DYRK21.21100769
35MAP3K131.13413931
36CAMK2A1.13360724
37CDK191.12354270
38CSNK1G31.10090812
39BMPR21.05796202
40CAMK2B1.01344620
41DYRK1A1.01335035
42UHMK10.99398450
43RAF10.97748868
44CDK180.96574313
45CSNK1A1L0.96534942
46NME10.95962503
47PTK2B0.94427831
48CDK150.92398802
49CDK140.91395261
50CSNK1G10.89304480
51LATS20.84526909
52STK380.81951892
53CDK11A0.80721920
54SGK2230.80059949
55SGK4940.80059949
56PAK30.77597734
57MAP3K20.77410278
58CAMK40.76928298
59CAMK10.74792424
60SIK30.74726855
61CAMKK20.73320625
62LIMK10.72129195
63TNK20.71288651
64PRKCE0.70592492
65SGK10.70450596
66TYRO30.69622537
67OXSR10.67083528
68MAP3K110.66652595
69SGK20.63972712
70NEK10.60874392
71ERBB20.60584216
72STK110.59988729
73CSNK1G20.59063884
74PRKCZ0.58413929
75MARK20.58332047
76TESK10.57527917
77CAMK2D0.57389775
78FER0.56833438
79ALK0.56797016
80CAMK1D0.55490274
81BRSK10.55157668
82BRAF0.55131187
83FGR0.55120817
84PRKCH0.54505287
85NEK60.53163769
86MAP3K10.52994324
87MAP4K20.52651261
88LMTK20.50222553
89PLK40.48115984
90TAOK10.47831572
91FYN0.45179938
92CAMK2G0.45120497
93GRK70.44566014
94BCR0.44418768
95MAPK100.44346662
96RPS6KA30.44292475
97WNK30.44020775
98MAP3K70.43636177
99AKT30.43139464
100ROCK20.43008786
101PKN10.42773300
102TAOK20.41654114
103CSNK1A10.41645429
104PINK10.41453778
105MAP2K10.40456800
106BMPR1B0.40254388
107RET0.39575944
108CCNB10.39333334
109SGK30.37842996
110PDPK10.37713628
111PDK10.37594093
112CAMK1G0.37060320
113CSNK1D0.37013036
114CSNK1E0.36452381
115PRKCA0.35911274
116ERBB30.35293673
117PRKACA0.33982527
118PRKCB0.32821101
119MAPK120.30737539
120ROCK10.29890861
121TSSK60.28715552
122STK160.28706762
123DMPK0.27205880
124OBSCN0.26899529
125PRKG10.25597101

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.73688530
2Synaptic vesicle cycle_Homo sapiens_hsa047213.32309841
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047233.13337804
4GABAergic synapse_Homo sapiens_hsa047273.01146352
5Morphine addiction_Homo sapiens_hsa050322.86921660
6Circadian entrainment_Homo sapiens_hsa047132.85757402
7Long-term potentiation_Homo sapiens_hsa047202.66372161
8Glutamatergic synapse_Homo sapiens_hsa047242.58545947
9Olfactory transduction_Homo sapiens_hsa047402.50204700
10Amphetamine addiction_Homo sapiens_hsa050312.37339176
11Salivary secretion_Homo sapiens_hsa049702.19901779
12Dopaminergic synapse_Homo sapiens_hsa047282.18409022
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.05256725
14Cholinergic synapse_Homo sapiens_hsa047251.96994190
15Serotonergic synapse_Homo sapiens_hsa047261.88214967
16Taste transduction_Homo sapiens_hsa047421.87736394
17Insulin secretion_Homo sapiens_hsa049111.87654935
18Collecting duct acid secretion_Homo sapiens_hsa049661.80380824
19Renin secretion_Homo sapiens_hsa049241.75025298
20Gastric acid secretion_Homo sapiens_hsa049711.74329849
21Oxytocin signaling pathway_Homo sapiens_hsa049211.73603776
22Aldosterone synthesis and secretion_Homo sapiens_hsa049251.72687857
23Long-term depression_Homo sapiens_hsa047301.71751488
24Calcium signaling pathway_Homo sapiens_hsa040201.69553652
25Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.59557075
26Cocaine addiction_Homo sapiens_hsa050301.50811101
27Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.42985381
28Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.37782853
29Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.35345707
30Axon guidance_Homo sapiens_hsa043601.34102104
31Gap junction_Homo sapiens_hsa045401.33995239
32GnRH signaling pathway_Homo sapiens_hsa049121.33674461
33cAMP signaling pathway_Homo sapiens_hsa040241.24330637
34Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.23634583
35Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.18668846
36Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.18592740
37Cardiac muscle contraction_Homo sapiens_hsa042601.17390682
38Vibrio cholerae infection_Homo sapiens_hsa051101.14891052
39Estrogen signaling pathway_Homo sapiens_hsa049151.09601827
40cGMP-PKG signaling pathway_Homo sapiens_hsa040221.04267547
41Glioma_Homo sapiens_hsa052141.04047383
42Vitamin B6 metabolism_Homo sapiens_hsa007501.01234364
43Melanogenesis_Homo sapiens_hsa049160.99942816
44Type II diabetes mellitus_Homo sapiens_hsa049300.97574081
45Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.97377741
46Phosphatidylinositol signaling system_Homo sapiens_hsa040700.96179710
47Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.92917921
48ErbB signaling pathway_Homo sapiens_hsa040120.92909451
49Phototransduction_Homo sapiens_hsa047440.89204881
50Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.87132985
51Vascular smooth muscle contraction_Homo sapiens_hsa042700.86378344
522-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.82190146
53Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.80441077
54Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.79966380
55Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.75109062
56Oocyte meiosis_Homo sapiens_hsa041140.74969727
57Dilated cardiomyopathy_Homo sapiens_hsa054140.73241054
58Pancreatic secretion_Homo sapiens_hsa049720.73139197
59Alzheimers disease_Homo sapiens_hsa050100.70040315
60Phospholipase D signaling pathway_Homo sapiens_hsa040720.69282535
61Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.68840844
62Choline metabolism in cancer_Homo sapiens_hsa052310.66296931
63Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.64956702
64Thyroid hormone synthesis_Homo sapiens_hsa049180.64587853
65Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.62642446
66MAPK signaling pathway_Homo sapiens_hsa040100.62076163
67Hippo signaling pathway_Homo sapiens_hsa043900.59571340
68Carbohydrate digestion and absorption_Homo sapiens_hsa049730.57970427
69Oxidative phosphorylation_Homo sapiens_hsa001900.57529632
70Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.56582198
71Ras signaling pathway_Homo sapiens_hsa040140.55781063
72Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.55528555
73Alcoholism_Homo sapiens_hsa050340.54942759
74VEGF signaling pathway_Homo sapiens_hsa043700.54672850
75Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.53252284
76Arginine and proline metabolism_Homo sapiens_hsa003300.52904693
77Glucagon signaling pathway_Homo sapiens_hsa049220.52255340
78Fatty acid biosynthesis_Homo sapiens_hsa000610.52188145
79Dorso-ventral axis formation_Homo sapiens_hsa043200.51187762
80Rap1 signaling pathway_Homo sapiens_hsa040150.47003285
81Prion diseases_Homo sapiens_hsa050200.43807139
82Thyroid hormone signaling pathway_Homo sapiens_hsa049190.42850167
83Endometrial cancer_Homo sapiens_hsa052130.42834087
84Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.41650551
85Wnt signaling pathway_Homo sapiens_hsa043100.41597261
86Neurotrophin signaling pathway_Homo sapiens_hsa047220.41151117
87Sphingolipid signaling pathway_Homo sapiens_hsa040710.40508698
88Circadian rhythm_Homo sapiens_hsa047100.37550392
89African trypanosomiasis_Homo sapiens_hsa051430.37360252
90Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.36620362
91Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.36518538
92Arginine biosynthesis_Homo sapiens_hsa002200.36163770
93Tight junction_Homo sapiens_hsa045300.36104186
94Huntingtons disease_Homo sapiens_hsa050160.35990556
95Renal cell carcinoma_Homo sapiens_hsa052110.35719148
96Bile secretion_Homo sapiens_hsa049760.34590731
97Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.34345937
98SNARE interactions in vesicular transport_Homo sapiens_hsa041300.34133157
99mTOR signaling pathway_Homo sapiens_hsa041500.33543813
100Hedgehog signaling pathway_Homo sapiens_hsa043400.32104574
101Butanoate metabolism_Homo sapiens_hsa006500.31906284
102Rheumatoid arthritis_Homo sapiens_hsa053230.30519870
103Ovarian steroidogenesis_Homo sapiens_hsa049130.29839281
104Parkinsons disease_Homo sapiens_hsa050120.29346451
105Basal cell carcinoma_Homo sapiens_hsa052170.29002643
106Inositol phosphate metabolism_Homo sapiens_hsa005620.28307848
107Endocytosis_Homo sapiens_hsa041440.28239607
108Type I diabetes mellitus_Homo sapiens_hsa049400.27600162
109Propanoate metabolism_Homo sapiens_hsa006400.27551909
110Non-small cell lung cancer_Homo sapiens_hsa052230.27544126
111Insulin signaling pathway_Homo sapiens_hsa049100.27185501
112Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.26554819
113beta-Alanine metabolism_Homo sapiens_hsa004100.25881229
114Histidine metabolism_Homo sapiens_hsa003400.24655245
115Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.24358866
116Longevity regulating pathway - mammal_Homo sapiens_hsa042110.23286577
117Colorectal cancer_Homo sapiens_hsa052100.23150709
118Ether lipid metabolism_Homo sapiens_hsa005650.22878933
119Chemokine signaling pathway_Homo sapiens_hsa040620.22722553
120Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.22335960
121Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.21962413

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