LRRTM2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuron cell-cell adhesion (GO:0007158)6.29858446
2presynaptic membrane assembly (GO:0097105)5.43963464
3locomotory exploration behavior (GO:0035641)5.30381588
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.06937740
5regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.05924740
6vocalization behavior (GO:0071625)5.05483078
7pyrimidine nucleobase catabolic process (GO:0006208)5.00292644
8presynaptic membrane organization (GO:0097090)4.91258879
9regulation of short-term neuronal synaptic plasticity (GO:0048172)4.82547773
10ionotropic glutamate receptor signaling pathway (GO:0035235)4.55154350
11synaptic vesicle exocytosis (GO:0016079)4.49545518
12protein localization to synapse (GO:0035418)4.45422762
13regulation of glutamate receptor signaling pathway (GO:1900449)4.38260233
14postsynaptic membrane organization (GO:0001941)4.32218322
15transmission of nerve impulse (GO:0019226)4.21253642
16nucleobase catabolic process (GO:0046113)4.19588242
17neuronal action potential propagation (GO:0019227)4.17722140
18exploration behavior (GO:0035640)4.14267086
19regulation of synaptic vesicle exocytosis (GO:2000300)4.09900743
20glutamate receptor signaling pathway (GO:0007215)4.07184298
21neurotransmitter-gated ion channel clustering (GO:0072578)4.05264050
22glutamate secretion (GO:0014047)3.99690165
23regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.96225988
24synaptic transmission, glutamatergic (GO:0035249)3.95523548
25positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.95138050
26neuron recognition (GO:0008038)3.91441100
27startle response (GO:0001964)3.89424311
28neuron-neuron synaptic transmission (GO:0007270)3.88082062
29gamma-aminobutyric acid signaling pathway (GO:0007214)3.85809583
30regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.84245664
31synaptic vesicle maturation (GO:0016188)3.82884515
32negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.59586746
33cerebellar granule cell differentiation (GO:0021707)3.58573173
34regulation of long-term neuronal synaptic plasticity (GO:0048169)3.57955235
35regulation of excitatory postsynaptic membrane potential (GO:0060079)3.54005330
36positive regulation of membrane potential (GO:0045838)3.53554370
37* long-term synaptic potentiation (GO:0060291)3.52274531
38regulation of synaptic vesicle transport (GO:1902803)3.51745802
39establishment of mitochondrion localization (GO:0051654)3.51280897
40regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.48422671
41dendritic spine morphogenesis (GO:0060997)3.47867361
42regulation of neuronal synaptic plasticity (GO:0048168)3.47027931
43negative regulation of neurotransmitter transport (GO:0051589)3.46956432
44regulation of synaptic transmission, glutamatergic (GO:0051966)3.46059992
45axonal fasciculation (GO:0007413)3.44984955
46membrane depolarization during action potential (GO:0086010)3.43995695
47positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.42947567
48gamma-aminobutyric acid transport (GO:0015812)3.42289341
49negative regulation of synaptic transmission, GABAergic (GO:0032229)3.41790013
50neurotransmitter secretion (GO:0007269)3.40288711
51long-term memory (GO:0007616)3.38960812
52positive regulation of synapse assembly (GO:0051965)3.38351120
53regulation of postsynaptic membrane potential (GO:0060078)3.36859721
54regulation of dendritic spine morphogenesis (GO:0061001)3.36437705
55axon ensheathment in central nervous system (GO:0032291)3.36429085
56central nervous system myelination (GO:0022010)3.36429085
57gonadal mesoderm development (GO:0007506)3.35543372
58negative regulation of neurotransmitter secretion (GO:0046929)3.24208060
59auditory behavior (GO:0031223)3.24055838
60layer formation in cerebral cortex (GO:0021819)3.21240553
61negative regulation of cytosolic calcium ion concentration (GO:0051481)3.20380052
62regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.20164779
63retinal cone cell development (GO:0046549)3.19553390
64central nervous system projection neuron axonogenesis (GO:0021952)3.18375248
65synapse assembly (GO:0007416)3.18024623
66synaptic vesicle docking involved in exocytosis (GO:0016081)3.17602069
67neurotransmitter uptake (GO:0001504)3.17029024
68L-amino acid import (GO:0043092)3.16469933
69membrane hyperpolarization (GO:0060081)3.14402960
70neuronal ion channel clustering (GO:0045161)3.13353689
71response to histamine (GO:0034776)3.13189133
72C4-dicarboxylate transport (GO:0015740)3.10993243
73adult walking behavior (GO:0007628)3.10094952
74* regulation of synaptic plasticity (GO:0048167)3.09633966
75innervation (GO:0060384)3.09316674
76membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.08062280
77positive regulation of synaptic transmission, GABAergic (GO:0032230)3.06373213
78G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.06045697
79long-chain fatty acid biosynthetic process (GO:0042759)3.05814087
80calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.04735500
81cellular potassium ion homeostasis (GO:0030007)3.02281342
82neuronal action potential (GO:0019228)3.01876883
83neurotransmitter transport (GO:0006836)3.00147246
84dendrite morphogenesis (GO:0048813)2.99217016
85positive regulation of dendritic spine morphogenesis (GO:0061003)2.99047964
86regulation of synapse structural plasticity (GO:0051823)2.98163612
87regulation of respiratory system process (GO:0044065)2.97446411
88learning (GO:0007612)2.97271859
89righting reflex (GO:0060013)2.96751543
90membrane assembly (GO:0071709)2.95855646
91regulation of dendritic spine development (GO:0060998)2.95574613
92mechanosensory behavior (GO:0007638)2.93639930
93neuromuscular synaptic transmission (GO:0007274)2.91313491
94cerebellar Purkinje cell differentiation (GO:0021702)2.90482176
95* synapse organization (GO:0050808)2.90111087
96membrane depolarization (GO:0051899)2.89566975
97glycosphingolipid biosynthetic process (GO:0006688)2.88552085
98positive regulation of dendritic spine development (GO:0060999)2.88260294
99proline transport (GO:0015824)2.87819152
100neurofilament cytoskeleton organization (GO:0060052)2.87572626
101regulation of glutamate secretion (GO:0014048)2.86854384
102behavioral response to nicotine (GO:0035095)2.85991878
103behavioral defense response (GO:0002209)2.85593465
104behavioral fear response (GO:0001662)2.85593465
105regulation of neurotransmitter secretion (GO:0046928)2.85083044
106response to auditory stimulus (GO:0010996)2.84987089
107negative regulation of synaptic transmission (GO:0050805)2.84955212
108dendrite development (GO:0016358)2.83889389
109regulation of neuron projection regeneration (GO:0070570)2.82184479
110regulation of axon regeneration (GO:0048679)2.82184479
111retinal ganglion cell axon guidance (GO:0031290)2.80065647
112acidic amino acid transport (GO:0015800)2.78056905
113positive regulation of potassium ion transmembrane transport (GO:1901381)2.78011881
114amino acid import (GO:0043090)2.77865594
115regulation of synaptic transmission, GABAergic (GO:0032228)2.77766533
116serotonin metabolic process (GO:0042428)2.77121515
117cerebral cortex radially oriented cell migration (GO:0021799)2.76410826
118behavioral response to cocaine (GO:0048148)2.75928705
119cochlea development (GO:0090102)2.75800246
120synaptic vesicle endocytosis (GO:0048488)2.75702436
121synaptic transmission (GO:0007268)2.75173637
122myelination (GO:0042552)2.75075089
123positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.74787688
124regulation of neurotransmitter levels (GO:0001505)2.73432814
125central nervous system neuron axonogenesis (GO:0021955)2.73101088
126positive regulation of synapse maturation (GO:0090129)2.71855874
127regulation of synapse assembly (GO:0051963)2.71624649
128* positive regulation of synaptic transmission (GO:0050806)2.71156872
129regulation of vesicle fusion (GO:0031338)2.70635114
130regulation of voltage-gated calcium channel activity (GO:1901385)2.69980229
131ensheathment of neurons (GO:0007272)2.68933435

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.74117140
2GBX2_23144817_ChIP-Seq_PC3_Human4.15994323
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.99218298
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.94701160
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.94683125
6SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.53560108
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.48723054
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.48723054
9TAF15_26573619_Chip-Seq_HEK293_Human2.46928147
10EZH2_27304074_Chip-Seq_ESCs_Mouse2.44679947
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.41879502
12AR_21572438_ChIP-Seq_LNCaP_Human2.40306631
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.39825563
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.35163577
15EED_16625203_ChIP-ChIP_MESCs_Mouse2.33556562
16MTF2_20144788_ChIP-Seq_MESCs_Mouse2.29968937
17SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.21428905
18REST_21632747_ChIP-Seq_MESCs_Mouse2.19656086
19CTBP2_25329375_ChIP-Seq_LNCAP_Human2.16471913
20ZFP57_27257070_Chip-Seq_ESCs_Mouse2.10237440
21DROSHA_22980978_ChIP-Seq_HELA_Human2.01670774
22CTBP1_25329375_ChIP-Seq_LNCAP_Human2.01478616
23EZH2_27294783_Chip-Seq_ESCs_Mouse2.00080129
24SUZ12_27294783_Chip-Seq_ESCs_Mouse2.00011995
25RNF2_27304074_Chip-Seq_ESCs_Mouse1.99389336
26* RARB_27405468_Chip-Seq_BRAIN_Mouse1.87120218
27ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.86675406
28* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.83784181
29SMAD4_21799915_ChIP-Seq_A2780_Human1.83474145
30PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.80402583
31GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.78824047
32P300_19829295_ChIP-Seq_ESCs_Human1.77189238
33POU3F2_20337985_ChIP-ChIP_501MEL_Human1.70829508
34SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.67960020
35REST_18959480_ChIP-ChIP_MESCs_Mouse1.67949793
36* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.67504867
37NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.67107501
38CBX2_27304074_Chip-Seq_ESCs_Mouse1.66595904
39SMAD3_21741376_ChIP-Seq_EPCs_Human1.65003084
40FUS_26573619_Chip-Seq_HEK293_Human1.63802514
41PIAS1_25552417_ChIP-Seq_VCAP_Human1.62603655
42SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.54626628
43RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.53699189
44PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.53469118
45ZNF274_21170338_ChIP-Seq_K562_Hela1.52852502
46GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.52265090
47CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.51079435
48CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.50106403
49RBPJ_22232070_ChIP-Seq_NCS_Mouse1.49208373
50ER_23166858_ChIP-Seq_MCF-7_Human1.47764245
51* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.44940349
52TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.43973852
53IKZF1_21737484_ChIP-ChIP_HCT116_Human1.42737892
54BMI1_23680149_ChIP-Seq_NPCS_Mouse1.41157880
55STAT3_23295773_ChIP-Seq_U87_Human1.39833576
56IGF1R_20145208_ChIP-Seq_DFB_Human1.38493415
57SOX2_21211035_ChIP-Seq_LN229_Gbm1.37372804
58AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.34648490
59AR_25329375_ChIP-Seq_VCAP_Human1.33837209
60NR3C1_23031785_ChIP-Seq_PC12_Mouse1.33669337
61HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.33244821
62CDX2_19796622_ChIP-Seq_MESCs_Mouse1.31886635
63RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.29535064
64VDR_22108803_ChIP-Seq_LS180_Human1.27735092
65SALL1_21062744_ChIP-ChIP_HESCs_Human1.27205588
66RNF2_27304074_Chip-Seq_NSC_Mouse1.26899823
67ZNF217_24962896_ChIP-Seq_MCF-7_Human1.25757607
68UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.24943446
69TCF4_23295773_ChIP-Seq_U87_Human1.23892820
70* CBP_20019798_ChIP-Seq_JUKART_Human1.23374023
71* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.23374023
72ARNT_22903824_ChIP-Seq_MCF-7_Human1.23371642
73TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.22252886
74SMAD_19615063_ChIP-ChIP_OVARY_Human1.21686132
75AHR_22903824_ChIP-Seq_MCF-7_Human1.18786710
76VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.17977702
77MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.16473600
78PRDM14_20953172_ChIP-Seq_ESCs_Human1.15375274
79NANOG_18555785_Chip-Seq_ESCs_Mouse1.14602395
80TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.14484874
81RING1B_27294783_Chip-Seq_ESCs_Mouse1.14367106
82RUNX2_22187159_ChIP-Seq_PCA_Human1.12694084
83P53_22127205_ChIP-Seq_FIBROBLAST_Human1.12140204
84TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09521603
85* FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.08277498
86TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.07275542
87* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.06962196
88AR_19668381_ChIP-Seq_PC3_Human1.06903448
89NR3C1_21868756_ChIP-Seq_MCF10A_Human1.06819086
90MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.06282839
91TP53_18474530_ChIP-ChIP_U2OS_Human1.05628253
92KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.05156149
93TP53_16413492_ChIP-PET_HCT116_Human1.05155408
94TAL1_26923725_Chip-Seq_HPCs_Mouse1.05022737
95STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.04759064
96JUN_21703547_ChIP-Seq_K562_Human1.04369180
97WT1_25993318_ChIP-Seq_PODOCYTE_Human1.01537132
98RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.01496500
99KDM2B_26808549_Chip-Seq_REH_Human1.01007932
100YAP1_20516196_ChIP-Seq_MESCs_Mouse1.00083401
101EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.99823062
102RING1B_27294783_Chip-Seq_NPCs_Mouse0.99766052
103E2F1_18555785_Chip-Seq_ESCs_Mouse0.99695107
104ERG_21242973_ChIP-ChIP_JURKAT_Human0.99434057
105EWS_26573619_Chip-Seq_HEK293_Human0.98286030
106CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97471552
107TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96147803
108POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.96147803
109CMYC_18555785_Chip-Seq_ESCs_Mouse0.95665921
110SOX9_26525672_Chip-Seq_HEART_Mouse0.95282269
111BCAT_22108803_ChIP-Seq_LS180_Human0.94581087
112FLI1_27457419_Chip-Seq_LIVER_Mouse0.94297049
113* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.94070905
114LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93686954
115P53_22387025_ChIP-Seq_ESCs_Mouse0.93425143

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.71893559
2MP0004859_abnormal_synaptic_plasticity5.17784119
3MP0003635_abnormal_synaptic_transmissio3.72631608
4MP0004270_analgesia3.55122515
5MP0009745_abnormal_behavioral_response3.28058205
6MP0009046_muscle_twitch3.11381461
7MP0002064_seizures3.09763181
8MP0002063_abnormal_learning/memory/cond2.97399927
9MP0005423_abnormal_somatic_nervous2.92521257
10MP0001968_abnormal_touch/_nociception2.91873470
11MP0001486_abnormal_startle_reflex2.78799319
12MP0002272_abnormal_nervous_system2.76980066
13MP0002572_abnormal_emotion/affect_behav2.72050727
14MP0002736_abnormal_nociception_after2.51462319
15MP0002734_abnormal_mechanical_nocicepti2.47734161
16MP0001501_abnormal_sleep_pattern2.31740399
17MP0001529_abnormal_vocalization2.27211112
18MP0000778_abnormal_nervous_system2.09729003
19MP0001440_abnormal_grooming_behavior2.09591819
20MP0002067_abnormal_sensory_capabilities2.05598286
21MP0002638_abnormal_pupillary_reflex2.03782716
22MP0002735_abnormal_chemical_nociception2.03353077
23MP0002822_catalepsy1.94431772
24MP0005646_abnormal_pituitary_gland1.86915240
25MP0000920_abnormal_myelination1.86810102
26MP0002733_abnormal_thermal_nociception1.83996857
27MP0006276_abnormal_autonomic_nervous1.82486556
28MP0005645_abnormal_hypothalamus_physiol1.82228458
29MP0001970_abnormal_pain_threshold1.80311450
30MP0002184_abnormal_innervation1.79347311
31MP0005386_behavior/neurological_phenoty1.77731657
32MP0004924_abnormal_behavior1.77731657
33MP0001905_abnormal_dopamine_level1.72594248
34MP0002557_abnormal_social/conspecific_i1.70271445
35MP0004142_abnormal_muscle_tone1.69204957
36MP0004742_abnormal_vestibular_system1.64115161
37MP0000569_abnormal_digit_pigmentation1.62486113
38MP0003329_amyloid_beta_deposits1.62445429
39MP0005171_absent_coat_pigmentation1.59984224
40MP0008569_lethality_at_weaning1.57192412
41MP0001984_abnormal_olfaction1.54346169
42MP0009780_abnormal_chondrocyte_physiolo1.51451035
43MP0000955_abnormal_spinal_cord1.50206601
44MP0003787_abnormal_imprinting1.48758002
45MP0004885_abnormal_endolymph1.48615722
46MP0002882_abnormal_neuron_morphology1.47460611
47MP0002066_abnormal_motor_capabilities/c1.43770384
48MP0004811_abnormal_neuron_physiology1.39025105
49MP0005409_darkened_coat_color1.38902091
50MP0001188_hyperpigmentation1.38833591
51MP0002102_abnormal_ear_morphology1.33433378
52MP0003690_abnormal_glial_cell1.27007888
53MP0001986_abnormal_taste_sensitivity1.26783696
54MP0001502_abnormal_circadian_rhythm1.25929026
55MP0004858_abnormal_nervous_system1.25889323
56MP0003122_maternal_imprinting1.22312804
57MP0003634_abnormal_glial_cell1.18775782
58MP0005187_abnormal_penis_morphology1.14236234
59MP0005551_abnormal_eye_electrophysiolog1.12393081
60MP0004145_abnormal_muscle_electrophysio1.10519406
61MP0001963_abnormal_hearing_physiology1.10296274
62MP0002152_abnormal_brain_morphology1.10267251
63MP0003631_nervous_system_phenotype1.08763263
64MP0002751_abnormal_autonomic_nervous1.08468141
65MP0003633_abnormal_nervous_system1.08198470
66MP0002229_neurodegeneration1.07506938
67MP0003632_abnormal_nervous_system1.06785619
68MP0008877_abnormal_DNA_methylation1.05104804
69MP0003879_abnormal_hair_cell1.00083802
70MP0004133_heterotaxia0.98311051
71MP0001177_atelectasis0.96773832
72MP0003136_yellow_coat_color0.95212183
73MP0000631_abnormal_neuroendocrine_gland0.94641886
74MP0002752_abnormal_somatic_nervous0.94016170
75MP0005499_abnormal_olfactory_system0.93833737
76MP0005394_taste/olfaction_phenotype0.93833737
77MP0004085_abnormal_heartbeat0.89084319
78MP0001485_abnormal_pinna_reflex0.88915342
79MP0002653_abnormal_ependyma_morphology0.83182758
80MP0005195_abnormal_posterior_eye0.81862941
81MP0001299_abnormal_eye_distance/0.81028302
82MP0000026_abnormal_inner_ear0.80450364
83MP0002069_abnormal_eating/drinking_beha0.79527688
84MP0002234_abnormal_pharynx_morphology0.79047206
85MP0002909_abnormal_adrenal_gland0.79001577
86MP0000751_myopathy0.78510255
87MP0002837_dystrophic_cardiac_calcinosis0.77050431
88MP0008874_decreased_physiological_sensi0.74668413
89MP0004215_abnormal_myocardial_fiber0.74370533
90MP0010386_abnormal_urinary_bladder0.73875651
91MP0006292_abnormal_olfactory_placode0.73464312
92MP0003172_abnormal_lysosome_physiology0.71232668
93MP0000647_abnormal_sebaceous_gland0.70365032
94MP0003890_abnormal_embryonic-extraembry0.70305600
95MP0002090_abnormal_vision0.69784770
96MP0003137_abnormal_impulse_conducting0.69658907
97MP0002928_abnormal_bile_duct0.69460238
98MP0000566_synostosis0.69422061
99MP0008872_abnormal_physiological_respon0.68502124
100MP0005248_abnormal_Harderian_gland0.64726290
101MP0001943_abnormal_respiration0.64391708
102MP0002876_abnormal_thyroid_physiology0.63868456
103MP0000604_amyloidosis0.62857192
104MP0005084_abnormal_gallbladder_morpholo0.61087275
105MP0000013_abnormal_adipose_tissue0.60465564
106MP0000427_abnormal_hair_cycle0.60413356
107MP0003938_abnormal_ear_development0.60199243
108MP0003861_abnormal_nervous_system0.56985530
109MP0001664_abnormal_digestion0.56953438
110MP0005535_abnormal_body_temperature0.56786695
111MP0005623_abnormal_meninges_morphology0.54991604
112MP0002108_abnormal_muscle_morphology0.53531743
113MP0005410_abnormal_fertilization0.52994881
114MP0010770_preweaning_lethality0.52814245
115MP0002082_postnatal_lethality0.52814245
116MP0005253_abnormal_eye_physiology0.51903702
117MP0010769_abnormal_survival0.50521228
118MP0004043_abnormal_pH_regulation0.50001465
119MP0006072_abnormal_retinal_apoptosis0.49841481
120MP0003121_genomic_imprinting0.48591600
121MP0010768_mortality/aging0.46992403

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.11123237
2Myokymia (HP:0002411)5.30588022
3Focal seizures (HP:0007359)5.05535495
4Atonic seizures (HP:0010819)4.98266190
5Epileptic encephalopathy (HP:0200134)4.59032916
6Hyperventilation (HP:0002883)4.58863357
7Febrile seizures (HP:0002373)4.06973177
8Broad-based gait (HP:0002136)3.97384444
9Absence seizures (HP:0002121)3.90019008
10Progressive cerebellar ataxia (HP:0002073)3.86151788
11Dialeptic seizures (HP:0011146)3.70543858
12Visual hallucinations (HP:0002367)3.70092337
13Generalized tonic-clonic seizures (HP:0002069)3.41550403
14Action tremor (HP:0002345)3.39231376
15Gaze-evoked nystagmus (HP:0000640)3.32597360
16Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.30378060
17Degeneration of the lateral corticospinal tracts (HP:0002314)3.30378060
18Neurofibrillary tangles (HP:0002185)3.23426107
19Dysmetria (HP:0001310)3.22804161
20Abnormality of the corticospinal tract (HP:0002492)3.14490382
21Fetal akinesia sequence (HP:0001989)3.08803050
22Drooling (HP:0002307)3.04971647
23Excessive salivation (HP:0003781)3.04971647
24Progressive inability to walk (HP:0002505)3.01240545
25Supranuclear gaze palsy (HP:0000605)2.96934852
26Absent speech (HP:0001344)2.96443015
27Blue irides (HP:0000635)2.95540056
28Spastic gait (HP:0002064)2.92275743
29Akinesia (HP:0002304)2.90700645
30Dysdiadochokinesis (HP:0002075)2.88132751
31Scanning speech (HP:0002168)2.80693822
32Cerebral inclusion bodies (HP:0100314)2.76361805
33Sensory axonal neuropathy (HP:0003390)2.74768725
34Ankle clonus (HP:0011448)2.64196335
35Impaired vibration sensation in the lower limbs (HP:0002166)2.61996460
36Intention tremor (HP:0002080)2.61121988
37Urinary bladder sphincter dysfunction (HP:0002839)2.61089013
38Truncal ataxia (HP:0002078)2.60752141
39Poor eye contact (HP:0000817)2.56827538
40Peripheral hypomyelination (HP:0007182)2.56160987
41Lissencephaly (HP:0001339)2.53701220
42Epileptiform EEG discharges (HP:0011182)2.50991519
43Anxiety (HP:0000739)2.48750343
44True hermaphroditism (HP:0010459)2.46519545
45Mutism (HP:0002300)2.44191280
46Insidious onset (HP:0003587)2.40949189
47Termporal pattern (HP:0011008)2.40949189
48Generalized myoclonic seizures (HP:0002123)2.40697463
49Inability to walk (HP:0002540)2.40213330
50Abnormal eating behavior (HP:0100738)2.38522769
51Status epilepticus (HP:0002133)2.36974515
52EEG with generalized epileptiform discharges (HP:0011198)2.35280179
53Abnormal social behavior (HP:0012433)2.35050358
54Impaired social interactions (HP:0000735)2.35050358
55Pheochromocytoma (HP:0002666)2.35004340
56Abnormality of salivation (HP:0100755)2.34657900
57Pachygyria (HP:0001302)2.32622651
58Protruding tongue (HP:0010808)2.31994083
59Gait imbalance (HP:0002141)2.31283751
60Limb dystonia (HP:0002451)2.30508422
61Type II lissencephaly (HP:0007260)2.28592054
62Pancreatic fibrosis (HP:0100732)2.26171485
63Agitation (HP:0000713)2.24189475
64Amblyopia (HP:0000646)2.23222889
65Postural instability (HP:0002172)2.22527280
66Hypsarrhythmia (HP:0002521)2.22484275
67Hemiplegia (HP:0002301)2.20071249
68Cortical dysplasia (HP:0002539)2.17952655
69Widely spaced teeth (HP:0000687)2.17533426
70Alacrima (HP:0000522)2.17352621
71Split foot (HP:0001839)2.16784165
72Abnormality of midbrain morphology (HP:0002418)2.15889766
73Molar tooth sign on MRI (HP:0002419)2.15889766
74Genetic anticipation (HP:0003743)2.15770739
75Hemiparesis (HP:0001269)2.15713937
76Depression (HP:0000716)2.15398482
77Thickened helices (HP:0000391)2.14453263
78Retinal dysplasia (HP:0007973)2.14209171
79Nephronophthisis (HP:0000090)2.08847701
80Fair hair (HP:0002286)2.08500956
81Lower limb muscle weakness (HP:0007340)2.07284153
82Clumsiness (HP:0002312)2.07272957
83Polyphagia (HP:0002591)2.06875583
84Abnormality of the labia minora (HP:0012880)2.05797287
85Poor coordination (HP:0002370)2.05083504
86Amyotrophic lateral sclerosis (HP:0007354)2.04884844
87Pancreatic cysts (HP:0001737)2.03951825
88Abnormality of binocular vision (HP:0011514)2.02894001
89Diplopia (HP:0000651)2.02894001
90Neuroendocrine neoplasm (HP:0100634)2.02693023
91Urinary urgency (HP:0000012)2.02650960
92Morphological abnormality of the pyramidal tract (HP:0002062)2.02299962
93Spastic tetraplegia (HP:0002510)2.01827181
94Methylmalonic acidemia (HP:0002912)2.00481240
95Megalencephaly (HP:0001355)1.95457569
96Congenital primary aphakia (HP:0007707)1.94837322
97Generalized hypopigmentation of hair (HP:0011358)1.94130696
98Synostosis involving the elbow (HP:0003938)1.94001847
99Humeroradial synostosis (HP:0003041)1.94001847
100Failure to thrive in infancy (HP:0001531)1.92679872
101Decreased lacrimation (HP:0000633)1.92093942
102Vaginal atresia (HP:0000148)1.91650041
103Genital tract atresia (HP:0001827)1.91644488
104Medial flaring of the eyebrow (HP:0010747)1.91395343
105Aplasia involving bones of the upper limbs (HP:0009823)1.91082534
106Aplasia of the phalanges of the hand (HP:0009802)1.91082534
107Aplasia involving bones of the extremities (HP:0009825)1.91082534
108Chronic hepatic failure (HP:0100626)1.88033288
109Gastroesophageal reflux (HP:0002020)1.87216856
110Specific learning disability (HP:0001328)1.85455112
111Bradykinesia (HP:0002067)1.84992573
112Stereotypic behavior (HP:0000733)1.84712085
113Optic nerve hypoplasia (HP:0000609)1.84127163
114Hypoplasia of the corpus callosum (HP:0002079)1.82701534
115Aqueductal stenosis (HP:0002410)1.82622568
116Cerebral hypomyelination (HP:0006808)1.81399105
117Impaired vibratory sensation (HP:0002495)1.78858504
118Abnormal hair whorl (HP:0010721)1.78109302
119Exotropia (HP:0000577)1.77572320
120Gait ataxia (HP:0002066)1.77482910
121Hypoplasia of the brainstem (HP:0002365)1.76530828
122Aplasia/Hypoplasia of the brainstem (HP:0007362)1.76530828
123Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.76324945
124Torticollis (HP:0000473)1.76170164
125Ulnar claw (HP:0001178)1.75131372
126Relative macrocephaly (HP:0004482)1.74689369
127Nephrogenic diabetes insipidus (HP:0009806)1.74568545
128Esotropia (HP:0000565)1.74503076
129Dynein arm defect of respiratory motile cilia (HP:0012255)1.73440355
130Aplasia/Hypoplasia of the lens (HP:0008063)1.69662942
131Sleep apnea (HP:0010535)1.69625144
132Intellectual disability, severe (HP:0010864)1.68822639
133Abnormality of the renal medulla (HP:0100957)1.67397341
134Bony spicule pigmentary retinopathy (HP:0007737)1.66773595

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.30694376
2CASK3.91878305
3EPHA43.82817420
4TNIK2.85955431
5MAP3K42.78725021
6MARK12.68984654
7MAP3K122.34471124
8MAP2K72.30104004
9OXSR12.30051988
10MAP3K92.14849205
11STK392.13405406
12MAP4K22.09994754
13PNCK1.98486590
14FRK1.97359189
15NTRK21.95920699
16PRPF4B1.88756833
17CDK191.87969126
18MINK11.83660979
19DYRK21.81196041
20NTRK11.70944021
21PINK11.63630288
22PAK61.60575633
23EPHA31.57592370
24RIPK41.55836399
25NEK61.53075724
26MAPK131.52566446
27MAP2K41.51620150
28CDK51.41777425
29TRIM281.41665808
30PLK21.40170338
31BCR1.37160310
32FES1.29371941
33CAMK2B1.27322562
34DAPK21.26352876
35UHMK11.22747160
36CAMK2A1.22741178
37TYRO31.22014546
38PKN11.13691903
39AKT31.08569783
40SGK4941.08561115
41SGK2231.08561115
42GRK51.07071640
43CSNK1G21.02410491
44PRKCG1.01270156
45STK38L0.99736877
46BMPR20.98824218
47WNK10.98577239
48MKNK20.96150664
49PHKG20.94241272
50PHKG10.94241272
51FGFR20.92521490
52KSR10.90409725
53FGR0.89917200
54KSR20.88513235
55CAMK2D0.88317410
56GRK70.86810048
57CDK140.85276931
58CDK180.84766025
59CDK150.82148365
60ICK0.80546600
61CSNK1G30.80398140
62ARAF0.76857132
63PAK30.75576724
64STK110.75228319
65CAMKK10.75012145
66PRKCE0.73903725
67ROCK20.73438450
68WNK40.72736152
69SGK20.72732130
70DAPK10.72367137
71TNK20.72063266
72GRK10.71381311
73SGK10.70199868
74CDK11A0.70158120
75CAMK2G0.68767703
76BMPR1B0.68039818
77LIMK10.65847194
78CAMKK20.65832315
79PRKCZ0.65754816
80CSNK1A1L0.65610892
81ERBB40.65172548
82MAPKAPK50.65093754
83ERBB30.64904188
84PTK2B0.64902691
85INSRR0.64549024
86NME10.64140727
87MUSK0.62459290
88MAP3K130.62348537
89DYRK1B0.59124814
90DYRK1A0.59121495
91CAMK40.58310843
92MAP3K20.58235357
93PRKD30.56536947
94NUAK10.56288497
95SIK20.56237932
96CAMK10.55241047
97PDPK10.55235103
98CCNB10.55102327
99MAPK150.53764191
100CAMK1G0.52796333
101PRKCQ0.52463871
102PRKCH0.52378284
103PRKACA0.51957455
104CSNK1G10.51946548
105EPHB20.49689453
106FER0.49330415
107CDK30.48656237
108CSNK1D0.48571810
109TAOK10.48516991
110FYN0.48036508
111MAPK70.47638134
112CSNK1E0.46959292
113ADRBK10.45888320
114WNK30.45478842
115ADRBK20.44772156
116PDK10.44013388
117LMTK20.43801858
118RET0.43582731
119DMPK0.43155871
120CSNK1A10.43140654
121PRKG10.42587323
122RPS6KA30.42184108
123STK380.41660338
124MARK20.41514856
125PRKACB0.41186374
126PRKAA10.37812602
127PRKCA0.35214957
128TAOK30.35136682
129ERBB20.34341298
130MAPK100.33480182
131MAP3K60.31573235
132PRKCB0.29654387
133MAPK120.29365616

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.10167644
2Synaptic vesicle cycle_Homo sapiens_hsa047212.90872584
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.85103270
4GABAergic synapse_Homo sapiens_hsa047272.72778567
5Glutamatergic synapse_Homo sapiens_hsa047242.63431233
6Morphine addiction_Homo sapiens_hsa050322.58039029
7Circadian entrainment_Homo sapiens_hsa047132.49177558
8Amphetamine addiction_Homo sapiens_hsa050312.37644994
9Long-term potentiation_Homo sapiens_hsa047202.34824990
10Olfactory transduction_Homo sapiens_hsa047402.31374703
11Dopaminergic synapse_Homo sapiens_hsa047282.11882263
12Serotonergic synapse_Homo sapiens_hsa047262.07758762
13Collecting duct acid secretion_Homo sapiens_hsa049662.03178353
14Salivary secretion_Homo sapiens_hsa049701.98072458
15Long-term depression_Homo sapiens_hsa047301.89722199
16Taste transduction_Homo sapiens_hsa047421.86369357
17Cholinergic synapse_Homo sapiens_hsa047251.76867658
18Cocaine addiction_Homo sapiens_hsa050301.71461082
19Axon guidance_Homo sapiens_hsa043601.65029311
20Insulin secretion_Homo sapiens_hsa049111.64904356
21Renin secretion_Homo sapiens_hsa049241.63048912
22Gastric acid secretion_Homo sapiens_hsa049711.59419124
23Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.57936066
24Calcium signaling pathway_Homo sapiens_hsa040201.49179627
25Oxytocin signaling pathway_Homo sapiens_hsa049211.45932304
26Vibrio cholerae infection_Homo sapiens_hsa051101.45114139
27Aldosterone synthesis and secretion_Homo sapiens_hsa049251.41419220
28Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.40684859
29Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.38698312
30Oxidative phosphorylation_Homo sapiens_hsa001901.36581778
31Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.28773905
32Gap junction_Homo sapiens_hsa045401.26823654
33Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.23378758
34Cardiac muscle contraction_Homo sapiens_hsa042601.23000870
35Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.21793495
36GnRH signaling pathway_Homo sapiens_hsa049121.21319287
37Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.19966908
38Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.17207294
39Circadian rhythm_Homo sapiens_hsa047101.13562155
40ErbB signaling pathway_Homo sapiens_hsa040121.13138225
41cAMP signaling pathway_Homo sapiens_hsa040241.12418584
42Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.09674495
43Alzheimers disease_Homo sapiens_hsa050101.08694167
44Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.08464802
45Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.06572610
46Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.01965472
47Vascular smooth muscle contraction_Homo sapiens_hsa042700.96635935
48Phototransduction_Homo sapiens_hsa047440.94256003
49Phosphatidylinositol signaling system_Homo sapiens_hsa040700.93583010
50Estrogen signaling pathway_Homo sapiens_hsa049150.92719408
51Glioma_Homo sapiens_hsa052140.92198120
52Dorso-ventral axis formation_Homo sapiens_hsa043200.90688305
53Parkinsons disease_Homo sapiens_hsa050120.90560747
54Melanogenesis_Homo sapiens_hsa049160.89674647
55Type II diabetes mellitus_Homo sapiens_hsa049300.87713685
56Ether lipid metabolism_Homo sapiens_hsa005650.85246268
57Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.84523770
58cGMP-PKG signaling pathway_Homo sapiens_hsa040220.84246456
59Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.83508948
60Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.82776686
61Choline metabolism in cancer_Homo sapiens_hsa052310.82519257
62Phospholipase D signaling pathway_Homo sapiens_hsa040720.80493235
63Pancreatic secretion_Homo sapiens_hsa049720.78513326
64Regulation of autophagy_Homo sapiens_hsa041400.76185196
65Ras signaling pathway_Homo sapiens_hsa040140.74333192
66Sphingolipid metabolism_Homo sapiens_hsa006000.72893793
67Dilated cardiomyopathy_Homo sapiens_hsa054140.71954055
68Rheumatoid arthritis_Homo sapiens_hsa053230.71842452
69MAPK signaling pathway_Homo sapiens_hsa040100.71576307
70Bile secretion_Homo sapiens_hsa049760.70709874
71Protein export_Homo sapiens_hsa030600.69164878
72Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.66116550
73Propanoate metabolism_Homo sapiens_hsa006400.65467494
74Sphingolipid signaling pathway_Homo sapiens_hsa040710.65437798
75Renal cell carcinoma_Homo sapiens_hsa052110.65342167
76ABC transporters_Homo sapiens_hsa020100.62708267
77Linoleic acid metabolism_Homo sapiens_hsa005910.62128909
78Oocyte meiosis_Homo sapiens_hsa041140.59870053
79beta-Alanine metabolism_Homo sapiens_hsa004100.59681834
80Thyroid hormone synthesis_Homo sapiens_hsa049180.56616668
81Huntingtons disease_Homo sapiens_hsa050160.56006201
82Histidine metabolism_Homo sapiens_hsa003400.55063199
83Alcoholism_Homo sapiens_hsa050340.52895130
84Steroid biosynthesis_Homo sapiens_hsa001000.52598956
85alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.51856732
86Nitrogen metabolism_Homo sapiens_hsa009100.51030631
87Butanoate metabolism_Homo sapiens_hsa006500.50582362
88Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.50191291
89Ovarian steroidogenesis_Homo sapiens_hsa049130.48979029
90Fatty acid elongation_Homo sapiens_hsa000620.46369258
91Type I diabetes mellitus_Homo sapiens_hsa049400.45046526
92Rap1 signaling pathway_Homo sapiens_hsa040150.44369194
93Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.43530952
94Hippo signaling pathway_Homo sapiens_hsa043900.43155684
95Endocytosis_Homo sapiens_hsa041440.43021674
96Tryptophan metabolism_Homo sapiens_hsa003800.41649669
97Fatty acid biosynthesis_Homo sapiens_hsa000610.40818362
98Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.39896760
99Basal transcription factors_Homo sapiens_hsa030220.39467350
100Prion diseases_Homo sapiens_hsa050200.38911065
101Wnt signaling pathway_Homo sapiens_hsa043100.38393040
102Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.38234582
103Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.38000476
104African trypanosomiasis_Homo sapiens_hsa051430.37186094
105Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.35100958
106Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.35086966
107Phagosome_Homo sapiens_hsa041450.34329172
108Tight junction_Homo sapiens_hsa045300.33896142
109Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.32326109
110Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.31901890
111Primary bile acid biosynthesis_Homo sapiens_hsa001200.31728636
112Inositol phosphate metabolism_Homo sapiens_hsa005620.30976433
113Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.30320424
114Hedgehog signaling pathway_Homo sapiens_hsa043400.28385132
115VEGF signaling pathway_Homo sapiens_hsa043700.26141164
116Neurotrophin signaling pathway_Homo sapiens_hsa047220.25888702
117Regulation of actin cytoskeleton_Homo sapiens_hsa048100.25370188
118Carbohydrate digestion and absorption_Homo sapiens_hsa049730.24460229
119Melanoma_Homo sapiens_hsa052180.24170803
120Chemokine signaling pathway_Homo sapiens_hsa040620.23829776

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »