LRRTM4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)6.43310725
2presynaptic membrane assembly (GO:0097105)6.18005484
3neuron cell-cell adhesion (GO:0007158)6.11195949
4vocalization behavior (GO:0071625)5.71870765
5regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.59061787
6positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.56941824
7regulation of glutamate receptor signaling pathway (GO:1900449)5.46244510
8presynaptic membrane organization (GO:0097090)5.43759709
9postsynaptic membrane organization (GO:0001941)5.41544750
10regulation of short-term neuronal synaptic plasticity (GO:0048172)5.19897245
11ionotropic glutamate receptor signaling pathway (GO:0035235)5.00382780
12protein localization to synapse (GO:0035418)4.95405594
13startle response (GO:0001964)4.83232336
14* neurotransmitter-gated ion channel clustering (GO:0072578)4.74705946
15synaptic vesicle docking involved in exocytosis (GO:0016081)4.64853859
16glutamate receptor signaling pathway (GO:0007215)4.61176756
17negative regulation of synaptic transmission, GABAergic (GO:0032229)4.59942259
18pyrimidine nucleobase catabolic process (GO:0006208)4.55630745
19synaptic transmission, glutamatergic (GO:0035249)4.54797156
20synaptic vesicle exocytosis (GO:0016079)4.50890583
21neuron-neuron synaptic transmission (GO:0007270)4.47748742
22glutamate secretion (GO:0014047)4.41390393
23membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.37524527
24long-term synaptic potentiation (GO:0060291)4.33977812
25cerebellar granule cell differentiation (GO:0021707)4.31819115
26regulation of synaptic vesicle exocytosis (GO:2000300)4.25523182
27locomotory exploration behavior (GO:0035641)4.19255828
28regulation of synaptic transmission, glutamatergic (GO:0051966)4.13198880
29regulation of excitatory postsynaptic membrane potential (GO:0060079)4.04774426
30positive regulation of synaptic transmission, glutamatergic (GO:0051968)4.03987623
31negative regulation of synaptic transmission, glutamatergic (GO:0051967)4.01020628
32regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.97386967
33behavioral response to nicotine (GO:0035095)3.97052432
34neuronal action potential propagation (GO:0019227)3.93405477
35gamma-aminobutyric acid signaling pathway (GO:0007214)3.91184487
36regulation of synaptic vesicle transport (GO:1902803)3.87895379
37neurotransmitter secretion (GO:0007269)3.83833141
38regulation of postsynaptic membrane potential (GO:0060078)3.80365777
39positive regulation of synapse assembly (GO:0051965)3.78345103
40nucleobase catabolic process (GO:0046113)3.77899234
41positive regulation of membrane potential (GO:0045838)3.75773316
42G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.71215381
43response to histamine (GO:0034776)3.70209748
44positive regulation of synapse maturation (GO:0090129)3.69327429
45central nervous system projection neuron axonogenesis (GO:0021952)3.67046013
46regulation of collateral sprouting (GO:0048670)3.65285817
47exploration behavior (GO:0035640)3.63655260
48gonadal mesoderm development (GO:0007506)3.59381300
49retinal cone cell development (GO:0046549)3.58999930
50nonmotile primary cilium assembly (GO:0035058)3.55841394
51regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.55481797
52synaptic vesicle maturation (GO:0016188)3.53839362
53regulation of translation, ncRNA-mediated (GO:0045974)3.51822899
54negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.51822899
55negative regulation of translation, ncRNA-mediated (GO:0040033)3.51822899
56regulation of neuronal synaptic plasticity (GO:0048168)3.50619885
57positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.49881819
58regulation of synaptic plasticity (GO:0048167)3.48917112
59regulation of synapse maturation (GO:0090128)3.46806528
60neuron recognition (GO:0008038)3.44064546
61negative regulation of dendrite morphogenesis (GO:0050774)3.43707560
62regulation of long-term neuronal synaptic plasticity (GO:0048169)3.42601714
63detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.41693563
64righting reflex (GO:0060013)3.41400114
65regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.40340970
66serotonin metabolic process (GO:0042428)3.39243737
67regulation of timing of cell differentiation (GO:0048505)3.37180691
68transferrin transport (GO:0033572)3.36816845
69long-term memory (GO:0007616)3.36399856
70central nervous system neuron axonogenesis (GO:0021955)3.36050631
71gamma-aminobutyric acid transport (GO:0015812)3.33947586
72female mating behavior (GO:0060180)3.33807592
73regulation of female receptivity (GO:0045924)3.33134739
74response to pheromone (GO:0019236)3.32033052
75positive regulation of synaptic transmission (GO:0050806)3.27074654
76positive regulation of synaptic transmission, GABAergic (GO:0032230)3.25699821
77behavioral fear response (GO:0001662)3.25570032
78behavioral defense response (GO:0002209)3.25570032
79regulation of meiosis I (GO:0060631)3.24903505
80energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.24552726
81ATP hydrolysis coupled proton transport (GO:0015991)3.24552726
82membrane depolarization (GO:0051899)3.23704370
83regulation of development, heterochronic (GO:0040034)3.23480326
84behavioral response to ethanol (GO:0048149)3.22722043
85regulation of synapse assembly (GO:0051963)3.19931279
86L-fucose catabolic process (GO:0042355)3.19824231
87fucose catabolic process (GO:0019317)3.19824231
88L-fucose metabolic process (GO:0042354)3.19824231
89striatum development (GO:0021756)3.19243006
90cerebellar Purkinje cell differentiation (GO:0021702)3.18884629
91negative regulation of dendrite development (GO:2000171)3.15656322
92ferric iron transport (GO:0015682)3.13750194
93trivalent inorganic cation transport (GO:0072512)3.13750194
94mechanosensory behavior (GO:0007638)3.13300224
95membrane depolarization during action potential (GO:0086010)3.11546712
96G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.11422379
97neurotransmitter transport (GO:0006836)3.10506037
98regulation of respiratory system process (GO:0044065)3.08825325
99proline transport (GO:0015824)3.08160300
100fear response (GO:0042596)3.07775363
101regulation of synaptic transmission, GABAergic (GO:0032228)3.06387878
102learning (GO:0007612)3.05454736
103regulation of synaptic transmission (GO:0050804)3.05174124
104synaptic transmission (GO:0007268)3.05124606
105axonal fasciculation (GO:0007413)3.04819889
106synapse assembly (GO:0007416)3.03606795
107cochlea development (GO:0090102)3.03049865
108innervation (GO:0060384)3.02670570
109regulation of synapse structural plasticity (GO:0051823)3.01157282
110membrane hyperpolarization (GO:0060081)3.00464982
111transmission of nerve impulse (GO:0019226)2.99210684
112cerebral cortex radially oriented cell migration (GO:0021799)2.97409504
113regulation of synapse organization (GO:0050807)2.97321030
114protein localization to cilium (GO:0061512)2.96351215
115auditory behavior (GO:0031223)2.95926164
116regulation of neurotransmitter secretion (GO:0046928)2.95254619
117detection of light stimulus involved in visual perception (GO:0050908)2.94925030
118detection of light stimulus involved in sensory perception (GO:0050962)2.94925030
119inner ear receptor stereocilium organization (GO:0060122)2.94922481
120neural tube formation (GO:0001841)2.93978582
121regulation of glutamate secretion (GO:0014048)2.92345587
122dendrite development (GO:0016358)2.92290160
123cAMP catabolic process (GO:0006198)2.90590798
124neuromuscular synaptic transmission (GO:0007274)2.88342388
125membrane assembly (GO:0071709)2.88250181
126reflex (GO:0060004)2.81523701
127protein K11-linked deubiquitination (GO:0035871)2.78476295
128limb bud formation (GO:0060174)2.76597495
129regulation of axon regeneration (GO:0048679)2.74898372
130regulation of neuron projection regeneration (GO:0070570)2.74898372
131neuronal action potential (GO:0019228)2.71269548
132epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.70066804
133DNA double-strand break processing (GO:0000729)2.69424826
134olfactory bulb development (GO:0021772)2.68731502
135tachykinin receptor signaling pathway (GO:0007217)2.65460859
136negative regulation of astrocyte differentiation (GO:0048712)2.64606767
137piRNA metabolic process (GO:0034587)2.64033980
138dentate gyrus development (GO:0021542)2.63708258
139regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.63553741
140protein polyglutamylation (GO:0018095)2.62985688
141adaptation of signaling pathway (GO:0023058)2.61509345
142retinal ganglion cell axon guidance (GO:0031290)2.60463993
143cilium morphogenesis (GO:0060271)2.60092953
144photoreceptor cell maintenance (GO:0045494)2.58008146
145dendrite morphogenesis (GO:0048813)2.53576984
146negative regulation of cytosolic calcium ion concentration (GO:0051481)2.48623372
147glycosphingolipid biosynthetic process (GO:0006688)2.47789396
148protein-cofactor linkage (GO:0018065)2.47381770
149auditory receptor cell stereocilium organization (GO:0060088)2.45748873
150regulation of cilium movement (GO:0003352)2.45172129
151positive regulation of cardiac muscle cell differentiation (GO:2000727)2.42977890
152regulation of action potential (GO:0098900)2.42843293
153platelet dense granule organization (GO:0060155)2.41451144
154adult walking behavior (GO:0007628)2.39206754
155positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.38509436
156regulation of sarcomere organization (GO:0060297)2.37221974
157positive regulation of amino acid transport (GO:0051957)2.36348514
158epithelial cilium movement (GO:0003351)2.35829973
159cilium organization (GO:0044782)2.35236857
160cilium assembly (GO:0042384)2.32504382
161positive regulation of meiosis (GO:0045836)2.32352982
162photoreceptor cell development (GO:0042461)2.32116418

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.35646163
2GBX2_23144817_ChIP-Seq_PC3_Human5.10279498
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.98648050
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.82099831
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.71257042
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.66816902
7VDR_22108803_ChIP-Seq_LS180_Human2.57053200
8SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.54324494
9TAF15_26573619_Chip-Seq_HEK293_Human2.49954235
10ZFP57_27257070_Chip-Seq_ESCs_Mouse2.47487673
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.43802210
12CTBP2_25329375_ChIP-Seq_LNCAP_Human2.41331609
13EZH2_27304074_Chip-Seq_ESCs_Mouse2.40676648
14SALL1_21062744_ChIP-ChIP_HESCs_Human2.39732526
15EED_16625203_ChIP-ChIP_MESCs_Mouse2.35794308
16JARID2_20075857_ChIP-Seq_MESCs_Mouse2.33216863
17REST_21632747_ChIP-Seq_MESCs_Mouse2.32717702
18CTBP1_25329375_ChIP-Seq_LNCAP_Human2.32064710
19RNF2_18974828_ChIP-Seq_MESCs_Mouse2.31986486
20EZH2_18974828_ChIP-Seq_MESCs_Mouse2.31986486
21SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.30840175
22GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.30432458
23TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.30348491
24CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.15261593
25SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.12096790
26MTF2_20144788_ChIP-Seq_MESCs_Mouse2.10090585
27* P300_19829295_ChIP-Seq_ESCs_Human2.06190915
28* SMAD4_21799915_ChIP-Seq_A2780_Human2.06121196
29SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.96375432
30* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.95708475
31RARB_27405468_Chip-Seq_BRAIN_Mouse1.94145715
32AR_21572438_ChIP-Seq_LNCaP_Human1.93754584
33RNF2_27304074_Chip-Seq_ESCs_Mouse1.92638513
34PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.89729486
35EZH2_27294783_Chip-Seq_ESCs_Mouse1.88228521
36* REST_18959480_ChIP-ChIP_MESCs_Mouse1.86327261
37SUZ12_27294783_Chip-Seq_ESCs_Mouse1.83102070
38DROSHA_22980978_ChIP-Seq_HELA_Human1.82209506
39* GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.80466150
40FUS_26573619_Chip-Seq_HEK293_Human1.79770785
41ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.79445996
42PIAS1_25552417_ChIP-Seq_VCAP_Human1.75814638
43NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.75320304
44CBX2_27304074_Chip-Seq_ESCs_Mouse1.73863438
45E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.72870686
46* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.69940782
47POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.66300943
48* SMAD3_21741376_ChIP-Seq_EPCs_Human1.63606857
49* AR_25329375_ChIP-Seq_VCAP_Human1.60241184
50IKZF1_21737484_ChIP-ChIP_HCT116_Human1.58113556
51MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.56050589
52* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.54283818
53TOP2B_26459242_ChIP-Seq_MCF-7_Human1.53508102
54CBP_20019798_ChIP-Seq_JUKART_Human1.52715650
55IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.52715650
56* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.52466978
57RNF2_27304074_Chip-Seq_NSC_Mouse1.50243032
58SMAD_19615063_ChIP-ChIP_OVARY_Human1.49792814
59* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.48988358
60RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.48018239
61PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.47992011
62* STAT3_23295773_ChIP-Seq_U87_Human1.47711965
63ZNF274_21170338_ChIP-Seq_K562_Hela1.46218249
64* SOX2_21211035_ChIP-Seq_LN229_Gbm1.42381563
65RBPJ_22232070_ChIP-Seq_NCS_Mouse1.42362471
66ER_23166858_ChIP-Seq_MCF-7_Human1.41832551
67TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.37700825
68IGF1R_20145208_ChIP-Seq_DFB_Human1.36860892
69* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.34265375
70CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.32888624
71* TCF4_23295773_ChIP-Seq_U87_Human1.32709293
72* TCF4_22108803_ChIP-Seq_LS180_Human1.32690325
73ARNT_22903824_ChIP-Seq_MCF-7_Human1.31166437
74UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.26506645
75JUN_21703547_ChIP-Seq_K562_Human1.26274915
76KLF5_20875108_ChIP-Seq_MESCs_Mouse1.26103081
77FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.24451753
78* EWS_26573619_Chip-Seq_HEK293_Human1.23183305
79TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.22852443
80NANOG_18555785_Chip-Seq_ESCs_Mouse1.22165589
81PRDM14_20953172_ChIP-Seq_ESCs_Human1.21287756
82* RUNX2_22187159_ChIP-Seq_PCA_Human1.20578002
83CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20200898
84IRF1_19129219_ChIP-ChIP_H3396_Human1.19463512
85* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.19341581
86NR3C1_23031785_ChIP-Seq_PC12_Mouse1.17848101
87SUZ12_27294783_Chip-Seq_NPCs_Mouse1.17304903
88EZH2_27294783_Chip-Seq_NPCs_Mouse1.17277171
89AHR_22903824_ChIP-Seq_MCF-7_Human1.16558165
90TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.16348493
91FLI1_27457419_Chip-Seq_LIVER_Mouse1.15704213
92FLI1_21867929_ChIP-Seq_TH2_Mouse1.13764151
93TP53_22573176_ChIP-Seq_HFKS_Human1.13516835
94YAP1_20516196_ChIP-Seq_MESCs_Mouse1.12972908
95VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.11847439
96ZNF217_24962896_ChIP-Seq_MCF-7_Human1.11232914
97* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.10711453
98PCGF2_27294783_Chip-Seq_ESCs_Mouse1.09292750
99E2F1_18555785_Chip-Seq_ESCs_Mouse1.09118394
100EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.08040937
101PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.08011811
102FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.06886499
103AR_19668381_ChIP-Seq_PC3_Human1.06849660
104P53_22127205_ChIP-Seq_FIBROBLAST_Human1.06693416
105SOX9_26525672_Chip-Seq_HEART_Mouse1.06346598
106MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.06307228
107PCGF2_27294783_Chip-Seq_NPCs_Mouse1.05844866
108MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.05836191
109* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.05538293
110NR3C1_21868756_ChIP-Seq_MCF10A_Human1.05399798
111P53_22387025_ChIP-Seq_ESCs_Mouse1.05139207
112TP53_18474530_ChIP-ChIP_U2OS_Human1.05098060
113ERG_21242973_ChIP-ChIP_JURKAT_Human1.04677861
114BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.04379316
115* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.04088030
116TAL1_26923725_Chip-Seq_HPCs_Mouse1.03612986
117CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.03181101
118NFE2_27457419_Chip-Seq_LIVER_Mouse1.02112279
119POU5F1_16153702_ChIP-ChIP_HESCs_Human1.02107313
120SMAD4_21741376_ChIP-Seq_EPCs_Human1.00802184
121KDM2B_26808549_Chip-Seq_REH_Human1.00521760
122TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.99879430
123NANOG_19829295_ChIP-Seq_ESCs_Human0.99820897
124SOX2_19829295_ChIP-Seq_ESCs_Human0.99820897
125MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.99033852
126TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98604053
127LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98485962
128BCAT_22108803_ChIP-Seq_LS180_Human0.98346630
129RING1B_27294783_Chip-Seq_ESCs_Mouse0.97636869
130TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96810602
131STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.95662547
132TP63_19390658_ChIP-ChIP_HaCaT_Human0.95085156

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.86506292
2MP0004859_abnormal_synaptic_plasticity5.40088764
3MP0003635_abnormal_synaptic_transmissio3.82540239
4MP0009745_abnormal_behavioral_response3.52731125
5MP0001968_abnormal_touch/_nociception3.16493387
6MP0002736_abnormal_nociception_after3.15610193
7MP0002063_abnormal_learning/memory/cond3.15257564
8MP0002064_seizures3.14855542
9MP0009046_muscle_twitch2.99206208
10MP0002572_abnormal_emotion/affect_behav2.90481552
11MP0002822_catalepsy2.81472010
12MP0004270_analgesia2.69262270
13MP0001501_abnormal_sleep_pattern2.59306192
14MP0002272_abnormal_nervous_system2.57766895
15MP0001486_abnormal_startle_reflex2.56842555
16MP0003787_abnormal_imprinting2.55648642
17MP0002735_abnormal_chemical_nociception2.46063222
18MP0005646_abnormal_pituitary_gland2.33212838
19MP0002102_abnormal_ear_morphology2.28055922
20MP0009780_abnormal_chondrocyte_physiolo2.27562131
21MP0000569_abnormal_digit_pigmentation2.23691311
22MP0001440_abnormal_grooming_behavior2.17003991
23MP0001529_abnormal_vocalization2.13465787
24MP0002734_abnormal_mechanical_nocicepti2.12956257
25MP0002067_abnormal_sensory_capabilities2.12395603
26MP0005423_abnormal_somatic_nervous2.12329828
27MP0001984_abnormal_olfaction2.07932844
28MP0003879_abnormal_hair_cell2.00408860
29MP0001188_hyperpigmentation1.86001111
30MP0002234_abnormal_pharynx_morphology1.85966906
31MP0002184_abnormal_innervation1.82634955
32MP0002876_abnormal_thyroid_physiology1.81741140
33MP0005171_absent_coat_pigmentation1.80983498
34MP0003122_maternal_imprinting1.78164866
35MP0000778_abnormal_nervous_system1.76168959
36MP0002557_abnormal_social/conspecific_i1.73636458
37MP0004142_abnormal_muscle_tone1.70877943
38MP0003718_maternal_effect1.67254518
39MP0006276_abnormal_autonomic_nervous1.65565356
40MP0004858_abnormal_nervous_system1.64928646
41MP0001970_abnormal_pain_threshold1.64841248
42MP0005386_behavior/neurological_phenoty1.63366168
43MP0004924_abnormal_behavior1.63366168
44MP0002733_abnormal_thermal_nociception1.62107422
45MP0005645_abnormal_hypothalamus_physiol1.56760941
46MP0008569_lethality_at_weaning1.51291277
47MP0002638_abnormal_pupillary_reflex1.49127905
48MP0008789_abnormal_olfactory_epithelium1.49033363
49MP0003183_abnormal_peptide_metabolism1.47284110
50MP0001905_abnormal_dopamine_level1.38999032
51MP0004147_increased_porphyrin_level1.38513928
52MP0004811_abnormal_neuron_physiology1.34739464
53MP0003890_abnormal_embryonic-extraembry1.34159909
54MP0005253_abnormal_eye_physiology1.30533236
55MP0000955_abnormal_spinal_cord1.29713680
56MP0002882_abnormal_neuron_morphology1.28241629
57MP0003119_abnormal_digestive_system1.26619385
58MP0002066_abnormal_motor_capabilities/c1.25778533
59MP0006072_abnormal_retinal_apoptosis1.20817939
60MP0001502_abnormal_circadian_rhythm1.19852713
61MP0008057_abnormal_DNA_replication1.17582636
62MP0008877_abnormal_DNA_methylation1.17072874
63MP0005187_abnormal_penis_morphology1.16661486
64MP0003195_calcinosis1.15215191
65MP0008058_abnormal_DNA_repair1.13429356
66MP0004133_heterotaxia1.13021586
67MP0010386_abnormal_urinary_bladder1.10150739
68MP0005367_renal/urinary_system_phenotyp1.07004523
69MP0000516_abnormal_urinary_system1.07004523
70MP0001963_abnormal_hearing_physiology1.06917805
71MP0002909_abnormal_adrenal_gland1.00124693
72MP0004085_abnormal_heartbeat0.98163243
73MP0005195_abnormal_posterior_eye0.97846443
74MP0002928_abnormal_bile_duct0.96719395
75MP0004742_abnormal_vestibular_system0.96399295
76MP0002152_abnormal_brain_morphology0.95428817
77MP0004885_abnormal_endolymph0.95276507
78MP0001485_abnormal_pinna_reflex0.93199868
79MP0003633_abnormal_nervous_system0.92765916
80MP0003698_abnormal_male_reproductive0.92595292
81MP0002069_abnormal_eating/drinking_beha0.92007858
82MP0003121_genomic_imprinting0.88482488
83MP0000631_abnormal_neuroendocrine_gland0.88448118
84MP0000751_myopathy0.87566894
85MP0002938_white_spotting0.87292672
86MP0005499_abnormal_olfactory_system0.86290239
87MP0005394_taste/olfaction_phenotype0.86290239
88MP0003631_nervous_system_phenotype0.86116436
89MP0003136_yellow_coat_color0.86061993
90MP0008872_abnormal_physiological_respon0.84365798
91MP0005551_abnormal_eye_electrophysiolog0.82972136
92MP0000427_abnormal_hair_cycle0.82631716
93MP0000026_abnormal_inner_ear0.81911018
94MP0001664_abnormal_digestion0.80755840
95MP0002233_abnormal_nose_morphology0.80274423
96MP0002751_abnormal_autonomic_nervous0.80206655
97MP0001929_abnormal_gametogenesis0.79553114
98MP0001293_anophthalmia0.79494652
99MP0004215_abnormal_myocardial_fiber0.79272735
100MP0003937_abnormal_limbs/digits/tail_de0.78835286
101MP0001177_atelectasis0.78013893
102MP0002752_abnormal_somatic_nervous0.75438433
103MP0002653_abnormal_ependyma_morphology0.74857618
104MP0002210_abnormal_sex_determination0.74775514
105MP0000049_abnormal_middle_ear0.74420484
106MP0004484_altered_response_of0.74108708
107MP0003329_amyloid_beta_deposits0.73519157
108MP0009697_abnormal_copulation0.73493341
109MP0002229_neurodegeneration0.73423858
110MP0003123_paternal_imprinting0.72269152
111MP0008874_decreased_physiological_sensi0.70434706
112MP0006292_abnormal_olfactory_placode0.70332423
113MP0008260_abnormal_autophagy0.69443083
114MP0002837_dystrophic_cardiac_calcinosis0.66336320
115MP0004043_abnormal_pH_regulation0.65150689
116MP0000013_abnormal_adipose_tissue0.64768070
117MP0003632_abnormal_nervous_system0.63483670
118MP0003646_muscle_fatigue0.61295173
119MP0005595_abnormal_vascular_smooth0.59849959
120MP0003634_abnormal_glial_cell0.59752698
121MP0001943_abnormal_respiration0.58491193
122MP0004145_abnormal_muscle_electrophysio0.57834987
123MP0001986_abnormal_taste_sensitivity0.52688818
124MP0005409_darkened_coat_color0.52140390
125MP0010770_preweaning_lethality0.51847530
126MP0002082_postnatal_lethality0.51847530
127MP0005084_abnormal_gallbladder_morpholo0.51148052
128MP0005535_abnormal_body_temperature0.50822421
129MP0010769_abnormal_survival0.48503513
130MP0003861_abnormal_nervous_system0.46705744

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.58264953
2Epileptic encephalopathy (HP:0200134)6.23612513
3Hyperventilation (HP:0002883)5.82586539
4Atonic seizures (HP:0010819)5.28653738
5Febrile seizures (HP:0002373)5.25554640
6Focal seizures (HP:0007359)5.13076657
7Myokymia (HP:0002411)4.49639769
8Absence seizures (HP:0002121)4.01853276
9Dialeptic seizures (HP:0011146)3.97386212
10Broad-based gait (HP:0002136)3.80760433
11Progressive cerebellar ataxia (HP:0002073)3.66195558
12Generalized tonic-clonic seizures (HP:0002069)3.47237892
13Pancreatic cysts (HP:0001737)3.38980623
14Gaze-evoked nystagmus (HP:0000640)3.37719056
15Amblyopia (HP:0000646)3.35701009
16Pancreatic fibrosis (HP:0100732)3.31119663
17Gait imbalance (HP:0002141)3.21321129
18Epileptiform EEG discharges (HP:0011182)3.16307348
19Abnormal hair whorl (HP:0010721)3.12825256
20Visual hallucinations (HP:0002367)3.12080266
21Blue irides (HP:0000635)3.09819704
22Hypothermia (HP:0002045)3.05455360
23Protruding tongue (HP:0010808)3.04230198
24True hermaphroditism (HP:0010459)3.03786741
25Poor suck (HP:0002033)2.98487608
26Medial flaring of the eyebrow (HP:0010747)2.97684655
27Congenital primary aphakia (HP:0007707)2.97654765
28Type II lissencephaly (HP:0007260)2.97607218
29Fetal akinesia sequence (HP:0001989)2.96657299
30Impaired vibration sensation in the lower limbs (HP:0002166)2.92607307
31Retinal dysplasia (HP:0007973)2.89226199
32Nephrogenic diabetes insipidus (HP:0009806)2.88428842
33Abnormal eating behavior (HP:0100738)2.87032797
34Abnormality of midbrain morphology (HP:0002418)2.86066649
35Molar tooth sign on MRI (HP:0002419)2.86066649
36Excessive salivation (HP:0003781)2.85719242
37Drooling (HP:0002307)2.85719242
38Dysdiadochokinesis (HP:0002075)2.75288989
39Nephronophthisis (HP:0000090)2.74603631
40Progressive inability to walk (HP:0002505)2.74349896
41Lissencephaly (HP:0001339)2.71419134
42EEG with generalized epileptiform discharges (HP:0011198)2.66906405
43Decreased circulating renin level (HP:0003351)2.64359940
44Polyphagia (HP:0002591)2.64343876
45Absent speech (HP:0001344)2.61276013
46Hyperglycinemia (HP:0002154)2.56428376
47Methylmalonic acidemia (HP:0002912)2.52664936
48Inability to walk (HP:0002540)2.51483488
49Abnormality of the lower motor neuron (HP:0002366)2.50166028
50Hypsarrhythmia (HP:0002521)2.48789570
51Pendular nystagmus (HP:0012043)2.47921728
52Fair hair (HP:0002286)2.46728819
53Poor coordination (HP:0002370)2.42965215
54Abnormality of the renal medulla (HP:0100957)2.40909651
55Poor eye contact (HP:0000817)2.34989719
56Abnormality of the renal cortex (HP:0011035)2.33436938
57Truncal ataxia (HP:0002078)2.33239012
58Acute necrotizing encephalopathy (HP:0006965)2.31155642
59Optic nerve hypoplasia (HP:0000609)2.30816097
60Cerebellar dysplasia (HP:0007033)2.30643586
61Scanning speech (HP:0002168)2.28065724
62Specific learning disability (HP:0001328)2.27159630
63Abolished electroretinogram (ERG) (HP:0000550)2.25686514
64Bradycardia (HP:0001662)2.25187126
65Narrow nasal bridge (HP:0000446)2.24265364
66Anxiety (HP:0000739)2.23533935
67Generalized hypopigmentation of hair (HP:0011358)2.22095601
68Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.21276051
69Congenital stationary night blindness (HP:0007642)2.20850039
70Abnormality of the astrocytes (HP:0100707)2.20836635
71Astrocytoma (HP:0009592)2.20836635
72Chronic hepatic failure (HP:0100626)2.20082875
73Abnormal mitochondria in muscle tissue (HP:0008316)2.18254047
74Abnormality of the labia minora (HP:0012880)2.16746936
75Renal cortical cysts (HP:0000803)2.14627622
76Impaired vibratory sensation (HP:0002495)2.12030046
77Pheochromocytoma (HP:0002666)2.11410730
78Glioma (HP:0009733)2.11314195
79Genital tract atresia (HP:0001827)2.11043224
80Vaginal atresia (HP:0000148)2.08978514
81Colon cancer (HP:0003003)2.08947629
82Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.08592980
83Abnormal social behavior (HP:0012433)2.06876742
84Impaired social interactions (HP:0000735)2.06876742
85Oligodactyly (hands) (HP:0001180)2.06093812
86Cystic liver disease (HP:0006706)2.04941485
87Aplasia/Hypoplasia of the tibia (HP:0005772)2.02713995
88Anencephaly (HP:0002323)2.02655866
89Progressive macrocephaly (HP:0004481)2.02464329
90Incomplete penetrance (HP:0003829)2.02033789
91Pachygyria (HP:0001302)2.01820521
92Failure to thrive in infancy (HP:0001531)2.00294853
93Sclerocornea (HP:0000647)2.00075076
94Depression (HP:0000716)2.00020155
95Dysmetria (HP:0001310)1.99957950
96Methylmalonic aciduria (HP:0012120)1.99693615
97Postaxial hand polydactyly (HP:0001162)1.98932741
98Ependymoma (HP:0002888)1.97947186
99Tubulointerstitial nephritis (HP:0001970)1.97473489
100Hemiparesis (HP:0001269)1.97066765
101Abnormality of salivation (HP:0100755)1.96171709
102Oligomenorrhea (HP:0000876)1.95428098
103Action tremor (HP:0002345)1.95413901
104Hypoventilation (HP:0002791)1.93882870
105Postaxial foot polydactyly (HP:0001830)1.93470334
106Aplasia/Hypoplasia of the tongue (HP:0010295)1.93295227
107Impaired smooth pursuit (HP:0007772)1.90629525
108Intestinal atresia (HP:0011100)1.90569465
109Dynein arm defect of respiratory motile cilia (HP:0012255)1.90555561
110Absent/shortened dynein arms (HP:0200106)1.90555561
111Widely spaced teeth (HP:0000687)1.89986614
112Aplasia/Hypoplasia of the uvula (HP:0010293)1.87417783
113Narrow forehead (HP:0000341)1.86471576
114Neuroendocrine neoplasm (HP:0100634)1.85897682
115Akinesia (HP:0002304)1.85429574
116Hip dysplasia (HP:0001385)1.84309366
117Esotropia (HP:0000565)1.83767789
118Dysmetric saccades (HP:0000641)1.83600114
119Bradykinesia (HP:0002067)1.83338737
120Volvulus (HP:0002580)1.82895170
121Limb hypertonia (HP:0002509)1.82670827
122Congenital sensorineural hearing impairment (HP:0008527)1.82532859
123Diplopia (HP:0000651)1.82286609
124Abnormality of binocular vision (HP:0011514)1.82286609
125Limb dystonia (HP:0002451)1.81870420
126Astigmatism (HP:0000483)1.81117161
127Gastroesophageal reflux (HP:0002020)1.79483221
128Thyroid-stimulating hormone excess (HP:0002925)1.79378109
129Spinal canal stenosis (HP:0003416)1.78980177
130Tented upper lip vermilion (HP:0010804)1.78754509
131Urinary bladder sphincter dysfunction (HP:0002839)1.78577367
132Birth length less than 3rd percentile (HP:0003561)1.78412603
133Thickened helices (HP:0000391)1.78333140
134Stomach cancer (HP:0012126)1.78195165
135Stereotypic behavior (HP:0000733)1.77312770
136Hepatoblastoma (HP:0002884)1.76634093
137Cupped ear (HP:0000378)1.76414048
138Small hand (HP:0200055)1.75375559
139Ankle clonus (HP:0011448)1.75360974
140Torticollis (HP:0000473)1.74725093
141Supernumerary spleens (HP:0009799)1.74476529
142Aplasia/Hypoplasia of the lens (HP:0008063)1.73901252
143Bony spicule pigmentary retinopathy (HP:0007737)1.73123127
144Focal dystonia (HP:0004373)1.72807429
145Mitochondrial inheritance (HP:0001427)1.72351478
146Dyskinesia (HP:0100660)1.71876661
147Genetic anticipation (HP:0003743)1.71453611
148Acute encephalopathy (HP:0006846)1.70708796
149Attenuation of retinal blood vessels (HP:0007843)1.69554333
150Abnormal biliary tract physiology (HP:0012439)1.69253757
151Bile duct proliferation (HP:0001408)1.69253757
152Renal hypoplasia (HP:0000089)1.68759242
153Status epilepticus (HP:0002133)1.68548440
154Generalized hypotonia (HP:0001290)1.67759796
155Congenital hepatic fibrosis (HP:0002612)1.66785331
156Aplasia/Hypoplasia of the fovea (HP:0008060)1.65690526
157Increased serum pyruvate (HP:0003542)1.65403594
158Abnormality of glycolysis (HP:0004366)1.65403594
159Sleep apnea (HP:0010535)1.64991712
160Hyperthyroidism (HP:0000836)1.64507166

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK7.00729993
2NTRK35.10164881
3WNK34.88035740
4FRK4.48193332
5PRPF4B3.41398870
6EPHA43.09869037
7SIK33.04123155
8MAP2K73.01023867
9MAP3K42.83881717
10AKT32.61057957
11MAP3K122.50496384
12PLK22.15766490
13DAPK11.94859144
14MAP4K21.93186493
15SGK21.87649935
16TRIM281.86614194
17TNIK1.83791649
18DAPK21.81377123
19NTRK21.81027247
20ZAK1.78758929
21MARK11.77719143
22MINK11.74051616
23MAPK131.73998047
24NUAK11.70047309
25KSR11.68810006
26TSSK61.64989444
27CDK191.64736416
28PNCK1.62151013
29BMPR1B1.50532797
30SGK2231.49795665
31SGK4941.49795665
32MAP2K41.46365399
33ERBB31.43598584
34CCNB11.40699197
35MAP3K91.37184609
36DYRK21.30765885
37BCR1.30007324
38PAK31.24570059
39ACVR1B1.24338820
40PRKCG1.21708841
41SGK31.19098467
42CSNK1G11.10467145
43BMPR21.08814463
44GRK11.08468697
45CSNK1G31.08076423
46CDK51.06722159
47CAMK2A1.06318058
48CSNK1A1L1.02823641
49GRK71.01564293
50PTK2B1.01178696
51PKN10.99482444
52CAMK2B0.96669214
53OXSR10.96273276
54NME10.93318042
55STK390.93127739
56TAOK30.91146339
57MKNK10.88990064
58GRK50.84202470
59BRAF0.84075247
60PLK30.81233586
61PIK3CA0.79015168
62FES0.78409593
63PRKCE0.77405747
64BCKDK0.76734614
65MUSK0.73036803
66VRK10.72495452
67SGK10.71841655
68FGFR20.71196986
69CDK30.69166143
70ADRBK20.68026553
71ARAF0.67836906
72YES10.67381096
73WNK40.67330155
74CDK180.65736860
75TLK10.65052946
76CAMKK10.64141794
77PAK60.63750229
78MKNK20.63203901
79PLK40.61898464
80CAMK10.61758311
81ADRBK10.60190814
82RIPK40.60070587
83INSRR0.59745571
84SRPK10.59670330
85PRKCZ0.59500767
86PRKD30.58345302
87CAMKK20.58062922
88NEK60.57898118
89CDK80.57794415
90TAOK20.57499480
91KSR20.54694758
92PHKG10.53865541
93PHKG20.53865541
94MAPK150.53579022
95CSNK1D0.52557261
96ERBB40.52107611
97PRKCH0.52010126
98CAMK1G0.51859629
99STK240.51129406
100STK38L0.49882551
101UHMK10.49064534
102CDK150.48233395
103MAPK70.47700564
104PINK10.47596957
105DYRK30.46512214
106NTRK10.46269762
107CDK140.45435988
108FER0.44975038
109PLK10.44515108
110CAMK1D0.44228271
111WEE10.43981660
112MAP3K20.42701765
113DYRK1A0.42266194
114RPS6KA20.42035029
115CAMK2D0.40526637
116CSNK1A10.40409192
117CSNK1G20.39893673
118SIK20.39794617
119RPS6KA40.38193001
120BRD40.37925659
121CDK11A0.37456340
122PRKACA0.37007331
123CAMK2G0.36624401
124RPS6KA30.36582169
125PRKAA10.36447433
126TTK0.36209686
127CAMK40.36057543
128PRKCI0.35475622
129OBSCN0.35278185
130ATM0.35201243
131CSNK1E0.34432810
132ERBB20.34391616
133MAP3K130.34317789
134RPS6KB10.34119567
135MYLK0.33937489
136CDC42BPA0.33395223
137MAP2K10.32465192
138MARK20.31687279
139PRKCB0.30998021
140MARK30.30547099
141RET0.29878023
142PRKG10.29638443
143PRKCA0.29030853
144PDK30.28416267
145PDK40.28416267
146TNK20.27553713
147MAP3K60.26795768
148PDK10.26572777
149STK380.26356301

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.86201259
2Synaptic vesicle cycle_Homo sapiens_hsa047213.72719110
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047233.15005044
4Collecting duct acid secretion_Homo sapiens_hsa049663.09740102
5Circadian entrainment_Homo sapiens_hsa047133.03425729
6Olfactory transduction_Homo sapiens_hsa047402.95263704
7Morphine addiction_Homo sapiens_hsa050322.85866562
8GABAergic synapse_Homo sapiens_hsa047272.80453842
9Long-term potentiation_Homo sapiens_hsa047202.56691003
10Glutamatergic synapse_Homo sapiens_hsa047242.54861767
11Amphetamine addiction_Homo sapiens_hsa050312.48845727
12Dopaminergic synapse_Homo sapiens_hsa047282.21125989
13Taste transduction_Homo sapiens_hsa047422.20768433
14Salivary secretion_Homo sapiens_hsa049702.04575284
15Vibrio cholerae infection_Homo sapiens_hsa051102.00549837
16Basal transcription factors_Homo sapiens_hsa030221.97040405
17Long-term depression_Homo sapiens_hsa047301.93903208
18Fanconi anemia pathway_Homo sapiens_hsa034601.92945038
19Serotonergic synapse_Homo sapiens_hsa047261.89164851
20Calcium signaling pathway_Homo sapiens_hsa040201.83623099
21Insulin secretion_Homo sapiens_hsa049111.82981747
22Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.78284956
23Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.76372689
24Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.76334507
25Propanoate metabolism_Homo sapiens_hsa006401.74326821
26Cholinergic synapse_Homo sapiens_hsa047251.68378653
27Renin secretion_Homo sapiens_hsa049241.66412422
28Non-homologous end-joining_Homo sapiens_hsa034501.61620186
29Cocaine addiction_Homo sapiens_hsa050301.56626556
30Steroid biosynthesis_Homo sapiens_hsa001001.54013854
31Linoleic acid metabolism_Homo sapiens_hsa005911.49136740
32Gastric acid secretion_Homo sapiens_hsa049711.47246383
33Protein export_Homo sapiens_hsa030601.46457752
34Aldosterone synthesis and secretion_Homo sapiens_hsa049251.43510824
35Oxytocin signaling pathway_Homo sapiens_hsa049211.40361509
36Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.37723783
37Ether lipid metabolism_Homo sapiens_hsa005651.36998951
38Caffeine metabolism_Homo sapiens_hsa002321.34537513
39alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.32538048
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.30496393
41Oxidative phosphorylation_Homo sapiens_hsa001901.29643737
42Homologous recombination_Homo sapiens_hsa034401.29314647
43Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.26945249
44Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.25498453
45Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.17772140
46Gap junction_Homo sapiens_hsa045401.16487683
47Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.15350151
48RNA polymerase_Homo sapiens_hsa030201.14682363
49Axon guidance_Homo sapiens_hsa043601.13809969
50Nitrogen metabolism_Homo sapiens_hsa009101.13709352
51cAMP signaling pathway_Homo sapiens_hsa040241.13423918
52GnRH signaling pathway_Homo sapiens_hsa049121.12748392
53Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.09756887
54Phototransduction_Homo sapiens_hsa047441.06832428
55Selenocompound metabolism_Homo sapiens_hsa004501.04396318
56Rheumatoid arthritis_Homo sapiens_hsa053231.02707967
57ABC transporters_Homo sapiens_hsa020101.01335425
58Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.00163918
59Tryptophan metabolism_Homo sapiens_hsa003800.98801756
60RNA degradation_Homo sapiens_hsa030180.97146172
61Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.96747286
62Peroxisome_Homo sapiens_hsa041460.95225291
63Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.94118034
64Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.93615274
65Maturity onset diabetes of the young_Homo sapiens_hsa049500.93575020
66cGMP-PKG signaling pathway_Homo sapiens_hsa040220.90768975
67Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.90474094
68Type II diabetes mellitus_Homo sapiens_hsa049300.88512627
69ErbB signaling pathway_Homo sapiens_hsa040120.88225143
70Primary bile acid biosynthesis_Homo sapiens_hsa001200.87889140
71Alzheimers disease_Homo sapiens_hsa050100.85478830
72Vascular smooth muscle contraction_Homo sapiens_hsa042700.84874877
73Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.84677968
74Phosphatidylinositol signaling system_Homo sapiens_hsa040700.84629279
75Melanogenesis_Homo sapiens_hsa049160.79312224
76Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.78996909
77Estrogen signaling pathway_Homo sapiens_hsa049150.74351300
78Glioma_Homo sapiens_hsa052140.74030850
79Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.72724643
80Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.72451291
81Type I diabetes mellitus_Homo sapiens_hsa049400.71521112
82Glycerolipid metabolism_Homo sapiens_hsa005610.71330045
83Cardiac muscle contraction_Homo sapiens_hsa042600.70058893
84Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.69901425
85Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.68539712
86Phagosome_Homo sapiens_hsa041450.67641348
87MAPK signaling pathway_Homo sapiens_hsa040100.66150718
88Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.65576941
89Parkinsons disease_Homo sapiens_hsa050120.64480666
90Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.63065933
91Fat digestion and absorption_Homo sapiens_hsa049750.62431413
92Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.58667669
93Circadian rhythm_Homo sapiens_hsa047100.58652535
94Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.57871937
95beta-Alanine metabolism_Homo sapiens_hsa004100.57646209
96Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.57561575
97Folate biosynthesis_Homo sapiens_hsa007900.56353917
98Hedgehog signaling pathway_Homo sapiens_hsa043400.55922982
99Dilated cardiomyopathy_Homo sapiens_hsa054140.55287550
100Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.54881465
101Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.54573948
102Fatty acid metabolism_Homo sapiens_hsa012120.54429035
103Steroid hormone biosynthesis_Homo sapiens_hsa001400.53635448
104Retinol metabolism_Homo sapiens_hsa008300.52991485
105Purine metabolism_Homo sapiens_hsa002300.51682884
106Alcoholism_Homo sapiens_hsa050340.51431766
107Ras signaling pathway_Homo sapiens_hsa040140.50319950
108Huntingtons disease_Homo sapiens_hsa050160.49780399
109Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.48841700
110Oocyte meiosis_Homo sapiens_hsa041140.48252407
111Fatty acid elongation_Homo sapiens_hsa000620.47770964
112Chemical carcinogenesis_Homo sapiens_hsa052040.47757040
113Cysteine and methionine metabolism_Homo sapiens_hsa002700.47651026
114Glucagon signaling pathway_Homo sapiens_hsa049220.46015300
115SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44786187
116Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.42480720
117Pancreatic secretion_Homo sapiens_hsa049720.41532351
118Dorso-ventral axis formation_Homo sapiens_hsa043200.41439501
119Thyroid hormone synthesis_Homo sapiens_hsa049180.38608547
120Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.38083271
121Mismatch repair_Homo sapiens_hsa034300.37223080
122Choline metabolism in cancer_Homo sapiens_hsa052310.36278852
123Histidine metabolism_Homo sapiens_hsa003400.35816048
124RNA transport_Homo sapiens_hsa030130.35082497
125Metabolic pathways_Homo sapiens_hsa011000.34961900
126Rap1 signaling pathway_Homo sapiens_hsa040150.34274354
127Butanoate metabolism_Homo sapiens_hsa006500.33907198
128Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.33533498
129Phospholipase D signaling pathway_Homo sapiens_hsa040720.32567329
130Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.31351200
131Wnt signaling pathway_Homo sapiens_hsa043100.31151188
132Melanoma_Homo sapiens_hsa052180.30374544
133Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.29828171
134African trypanosomiasis_Homo sapiens_hsa051430.28974851
135Neurotrophin signaling pathway_Homo sapiens_hsa047220.28599142
136Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.28590895
137Ovarian steroidogenesis_Homo sapiens_hsa049130.28546483
138Inositol phosphate metabolism_Homo sapiens_hsa005620.28095789
139Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.27444345
140Pyruvate metabolism_Homo sapiens_hsa006200.25903711
141Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.25505956
1422-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.23243647
143Regulation of autophagy_Homo sapiens_hsa041400.22718037
144Prion diseases_Homo sapiens_hsa050200.20584111
145Insulin signaling pathway_Homo sapiens_hsa049100.16122313
146Endometrial cancer_Homo sapiens_hsa052130.14197427
147Thyroid hormone signaling pathway_Homo sapiens_hsa049190.12820120
148Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.11650344

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