LRSAM1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a ring finger protein involved in a variety of functions, including regulation of signaling pathways and cell adhesion, mediation of self-ubiquitylation, and involvement in cargo sorting during receptor endocytosis. Mutations in this gene have been associated with Charcot-Marie-Tooth disease. Multiple transcript variants encoding different isoforms have been identified for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)4.76511976
2mannose metabolic process (GO:0006013)4.64342294
3cell migration in hindbrain (GO:0021535)4.33575689
4regulation of short-term neuronal synaptic plasticity (GO:0048172)4.24267323
5glutamate secretion (GO:0014047)4.21019067
6positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.17575069
7negative regulation of erythrocyte differentiation (GO:0045647)4.06875327
8neurofilament cytoskeleton organization (GO:0060052)4.04625786
9proline transport (GO:0015824)3.90338959
10synaptic vesicle exocytosis (GO:0016079)3.84003516
11G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.76128200
12regulation of synaptic vesicle exocytosis (GO:2000300)3.67208017
13neuronal action potential propagation (GO:0019227)3.63919544
14regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.62246398
15cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.60662529
16detection of temperature stimulus (GO:0016048)3.58796990
17negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.56348893
18negative regulation of microtubule polymerization (GO:0031115)3.54379297
19sodium ion export (GO:0071436)3.53158585
20plasma membrane repair (GO:0001778)3.53113214
21cell communication involved in cardiac conduction (GO:0086065)3.51909336
22activation of protein kinase A activity (GO:0034199)3.49957918
23detection of temperature stimulus involved in sensory perception of pain (GO:0050965)3.48737424
24detection of temperature stimulus involved in sensory perception (GO:0050961)3.48737424
25regulation of ARF protein signal transduction (GO:0032012)3.45414907
26membrane depolarization during action potential (GO:0086010)3.44097388
27positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.43660701
28neurotransmitter secretion (GO:0007269)3.43023712
29cell communication by electrical coupling (GO:0010644)3.36633959
30layer formation in cerebral cortex (GO:0021819)3.33341801
31positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.29850641
32cellular potassium ion homeostasis (GO:0030007)3.26641429
33alanine transport (GO:0032328)3.23230532
34neuromuscular process controlling posture (GO:0050884)3.22954231
35mitochondrion localization (GO:0051646)3.20686949
36regulation of ARF GTPase activity (GO:0032312)3.19744607
37axon cargo transport (GO:0008088)3.19264685
38negative regulation of dendrite morphogenesis (GO:0050774)3.18630168
39membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.17517198
40synaptic vesicle docking involved in exocytosis (GO:0016081)3.17085791
41regulation of NFAT protein import into nucleus (GO:0051532)3.16719006
42locomotory exploration behavior (GO:0035641)3.16263932
43cell-cell junction maintenance (GO:0045217)3.16169554
44regulation of synaptic vesicle transport (GO:1902803)3.14048079
45barbed-end actin filament capping (GO:0051016)3.11054832
46activation of MAPKKK activity (GO:0000185)3.09048681
47organelle transport along microtubule (GO:0072384)3.02027593
48epithelial cell differentiation involved in prostate gland development (GO:0060742)3.01252528
49regulation of synapse structural plasticity (GO:0051823)3.01158618
50mating behavior (GO:0007617)3.00303588
51vocalization behavior (GO:0071625)2.96328124
52neuron cell-cell adhesion (GO:0007158)2.94862508
53pyrimidine nucleobase catabolic process (GO:0006208)2.94179377
54positive regulation of potassium ion transmembrane transport (GO:1901381)2.93616977
55negative regulation of type 2 immune response (GO:0002829)2.92782202
56vesicle transport along microtubule (GO:0047496)2.91801727
57positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.89715722
58calcium-mediated signaling using intracellular calcium source (GO:0035584)2.89662136
59regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.89461041
60mitochondrion transport along microtubule (GO:0047497)2.88516789
61establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.88516789
62cerebellar granule cell differentiation (GO:0021707)2.88130241
63regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.87187188
64axon extension (GO:0048675)2.84797370
65regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.83468298
66innervation (GO:0060384)2.81137456
67gamma-aminobutyric acid transport (GO:0015812)2.80722507
68cytoskeletal anchoring at plasma membrane (GO:0007016)2.78250623
69membrane repolarization (GO:0086009)2.77146102
70establishment of mitochondrion localization (GO:0051654)2.77058051
71regulation of T-helper 2 cell differentiation (GO:0045628)2.76731313
72semaphorin-plexin signaling pathway (GO:0071526)2.76437430
73neuronal action potential (GO:0019228)2.76177954
74retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.75844447
75stress fiber assembly (GO:0043149)2.75837134
76regulation of sodium ion transmembrane transporter activity (GO:2000649)2.75110962
77response to peptidoglycan (GO:0032494)2.73526534
78cerebellar Purkinje cell differentiation (GO:0021702)2.73101654
79synaptic vesicle endocytosis (GO:0048488)2.72951795
80response to muramyl dipeptide (GO:0032495)2.71286710
81negative regulation of potassium ion transmembrane transport (GO:1901380)2.70547429
82axonal fasciculation (GO:0007413)2.70004359
83dendrite morphogenesis (GO:0048813)2.69202119
84signal complex assembly (GO:0007172)2.69158762
85neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.68247667
86regulation of neuronal synaptic plasticity (GO:0048168)2.68155535
87protein localization to synapse (GO:0035418)2.68078661
88neurotransmitter transport (GO:0006836)2.67401841
89neuromuscular synaptic transmission (GO:0007274)2.67322707
90macrophage activation involved in immune response (GO:0002281)2.64506327
91creatine metabolic process (GO:0006600)2.63992451
92glycine transport (GO:0015816)2.63362882
93negative regulation of cell size (GO:0045792)2.62910922
94neuromuscular process controlling balance (GO:0050885)2.62638918
95negative regulation of dendrite development (GO:2000171)2.62528739
96peptidyl-tyrosine autophosphorylation (GO:0038083)2.62297994
97positive regulation of synapse maturation (GO:0090129)2.61550706
98regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.61422032
99positive regulation of Cdc42 GTPase activity (GO:0043089)2.60991199
100nucleobase catabolic process (GO:0046113)2.60802470
101regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.59971481
102positive regulation of sodium ion transport (GO:0010765)2.59480540
103regulation of membrane repolarization (GO:0060306)2.58863342
104Golgi transport vesicle coating (GO:0048200)2.58687255
105COPI coating of Golgi vesicle (GO:0048205)2.58687255
106regulation of sodium ion transmembrane transport (GO:1902305)2.57858406
107regulation of hydrogen peroxide metabolic process (GO:0010310)2.56245296
108regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.55730978
109regulation of neurotransmitter levels (GO:0001505)2.55001102
110positive regulation of axon extension (GO:0045773)2.54920212
111membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.54715803
112histone H4 deacetylation (GO:0070933)2.52307274
113adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.50847564
114exploration behavior (GO:0035640)2.49879698
115intracellular estrogen receptor signaling pathway (GO:0030520)2.49769316
116retrograde transport, endosome to Golgi (GO:0042147)2.48595733
117neuron projection extension (GO:1990138)2.48229644
118cellular sodium ion homeostasis (GO:0006883)2.47592445
119neuron recognition (GO:0008038)2.43074186
120positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.42040745
121positive regulation of potassium ion transport (GO:0043268)2.42034809
122regulation of glutamate receptor signaling pathway (GO:1900449)2.41667176
123positive regulation of gamma-delta T cell activation (GO:0046645)2.41318242
124glucose 6-phosphate metabolic process (GO:0051156)2.40777566
125activation of Rac GTPase activity (GO:0032863)2.39352334
126protein localization to endosome (GO:0036010)2.39249637
127neuronal ion channel clustering (GO:0045161)2.39195571
128cell junction maintenance (GO:0034331)2.38543168
129negative regulation of sodium ion transport (GO:0010766)2.36043307
130regulation of calcium ion transmembrane transport (GO:1903169)2.35932837
131regulation of calcium ion transmembrane transporter activity (GO:1901019)2.35932837
132macroautophagy (GO:0016236)2.35542976
133positive regulation of axonogenesis (GO:0050772)2.33339756
134regulation of potassium ion transmembrane transport (GO:1901379)2.32915081
135detection of bacterium (GO:0016045)2.32811758
136regulation of neurotransmitter secretion (GO:0046928)2.32667757
137potassium ion import (GO:0010107)2.32625421
138Arp2/3 complex-mediated actin nucleation (GO:0034314)2.31751327
139regulation of regulated secretory pathway (GO:1903305)2.31301848
140regulation of leukocyte degranulation (GO:0043300)2.30793069
141modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.30213116
142positive regulation by organism of defense response of other organism involved in symbiotic interact2.30213116
143modulation by symbiont of host immune response (GO:0052553)2.30213116
144positive regulation by symbiont of host defense response (GO:0052509)2.30213116
145modulation by symbiont of host defense response (GO:0052031)2.30213116
146modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.30213116
147negative regulation of Ras protein signal transduction (GO:0046580)2.27424243
148detection of other organism (GO:0098543)2.25317277
149tricarboxylic acid metabolic process (GO:0072350)2.24486324
150dopamine receptor signaling pathway (GO:0007212)2.24068791
151regulation of myeloid leukocyte mediated immunity (GO:0002886)2.22801227
152adenosine receptor signaling pathway (GO:0001973)2.17544742
153histone H3 deacetylation (GO:0070932)2.15990037
154germinal center formation (GO:0002467)2.15537014
155regulation of interferon-beta biosynthetic process (GO:0045357)2.15429384
156regulation of defense response to virus by virus (GO:0050690)2.15220280
157phosphatidylglycerol biosynthetic process (GO:0006655)2.15155349
158actin filament polymerization (GO:0030041)2.15118501
159defense response to protozoan (GO:0042832)2.14904202
160negative regulation of small GTPase mediated signal transduction (GO:0051058)2.14846455
161ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.13518242
162regulation of cholesterol biosynthetic process (GO:0045540)2.11914832
163regulation of type 2 immune response (GO:0002828)2.11349119
164negative regulation of interleukin-2 production (GO:0032703)2.10130621
165positive regulation of histone deacetylation (GO:0031065)2.08442828
166response to manganese ion (GO:0010042)2.08354470
167regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.08198025
168response to protozoan (GO:0001562)2.05693830
169negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.05462090
170negative regulation of cell killing (GO:0031342)2.05462090
171regulation of synapse maturation (GO:0090128)2.05174391
172negative regulation of cytokine production involved in immune response (GO:0002719)2.03924232
173amyloid precursor protein catabolic process (GO:0042987)2.03583194
174protein insertion into membrane (GO:0051205)2.02686655
175thymic T cell selection (GO:0045061)2.01096085
176regulation of type I interferon-mediated signaling pathway (GO:0060338)1.99269297
177focal adhesion assembly (GO:0048041)1.98946940
178cell-substrate adherens junction assembly (GO:0007045)1.98946940
179lipopolysaccharide-mediated signaling pathway (GO:0031663)1.98779716

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.82737708
2VDR_21846776_ChIP-Seq_THP-1_Human2.91128469
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.66400191
4STAT6_21828071_ChIP-Seq_BEAS2B_Human2.49928401
5* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.40450055
6DROSHA_22980978_ChIP-Seq_HELA_Human2.40099324
7KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.35770434
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.35445741
9SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.34772237
10MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.20138622
11MYC_22102868_ChIP-Seq_BL_Human2.19247134
12* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.18890946
13* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.18890946
14SRY_22984422_ChIP-ChIP_TESTIS_Rat2.18203070
15NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.15807314
16TP63_17297297_ChIP-ChIP_HaCaT_Human2.14309846
17MTF2_20144788_ChIP-Seq_MESCs_Mouse2.14032399
18ELK3_25401928_ChIP-Seq_HUVEC_Human2.13885361
19TCF7_22412390_ChIP-Seq_EML_Mouse2.12765875
20REST_21632747_ChIP-Seq_MESCs_Mouse2.12110392
21SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.11613058
22TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.10948418
23JARID2_20075857_ChIP-Seq_MESCs_Mouse2.06723080
24RARB_27405468_Chip-Seq_BRAIN_Mouse2.04032170
25NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.03516480
26ERG_21242973_ChIP-ChIP_JURKAT_Human2.00801914
27REST_18959480_ChIP-ChIP_MESCs_Mouse1.99738978
28RACK7_27058665_Chip-Seq_MCF-7_Human1.97357322
29JARID2_20064375_ChIP-Seq_MESCs_Mouse1.91307842
30SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.88969960
31P68_20966046_ChIP-Seq_HELA_Human1.85915891
32SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.84188674
33ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.83780690
34SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.81805114
35ZFP281_18757296_ChIP-ChIP_E14_Mouse1.77086823
36SUZ12_27294783_Chip-Seq_ESCs_Mouse1.75569534
37TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.74064999
38KDM2B_26808549_Chip-Seq_K562_Human1.73550548
39EZH2_27294783_Chip-Seq_ESCs_Mouse1.71214984
40ESR2_21235772_ChIP-Seq_MCF-7_Human1.67652298
41EED_16625203_ChIP-ChIP_MESCs_Mouse1.65396567
42* TET1_21451524_ChIP-Seq_MESCs_Mouse1.64971624
43VDR_24763502_ChIP-Seq_THP-1_Human1.63019358
44RNF2_27304074_Chip-Seq_ESCs_Mouse1.61939226
45NR3C1_23031785_ChIP-Seq_PC12_Mouse1.60549630
46ELF1_20517297_ChIP-Seq_JURKAT_Human1.60151705
47NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.59400046
48EZH2_27304074_Chip-Seq_ESCs_Mouse1.54525336
49RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.54441367
50GBX2_23144817_ChIP-Seq_PC3_Human1.54128477
51E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.52912610
52CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.52454567
53GATA1_19941827_ChIP-Seq_MEL_Mouse1.52410694
54EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.51930703
55KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.50974940
56ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.50332938
57PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.50090105
58SA1_27219007_Chip-Seq_ERYTHROID_Human1.49819545
59KDM2B_26808549_Chip-Seq_JURKAT_Human1.48546637
60CTCF_27219007_Chip-Seq_ERYTHROID_Human1.47248638
61DNAJC2_21179169_ChIP-ChIP_NT2_Human1.47186966
62ZNF263_19887448_ChIP-Seq_K562_Human1.44689156
63MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.42539843
64ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.40984338
65UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.40881302
66TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.38208454
67MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.37778302
68KDM2B_26808549_Chip-Seq_SUP-B15_Human1.37656753
69SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.37352077
70STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.36203542
71* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.36127667
72IKZF1_21737484_ChIP-ChIP_HCT116_Human1.35616211
73MAF_26560356_Chip-Seq_TH1_Human1.35423567
74THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.34860844
75BCOR_27268052_Chip-Seq_Bcells_Human1.34339571
76SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.33848348
77ESR1_20079471_ChIP-ChIP_T-47D_Human1.32540668
78* BCL6_27268052_Chip-Seq_Bcells_Human1.30770673
79AHR_22903824_ChIP-Seq_MCF-7_Human1.30629960
80CTCF_27219007_Chip-Seq_Bcells_Human1.29827262
81LXR_22292898_ChIP-Seq_THP-1_Human1.29756169
82MAF_26560356_Chip-Seq_TH2_Human1.28536718
83WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.28068952
84* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.26937221
85* VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.26381824
86WT1_25993318_ChIP-Seq_PODOCYTE_Human1.26212867
87ZNF274_21170338_ChIP-Seq_K562_Hela1.25810616
88RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.24534222
89IRF8_22096565_ChIP-ChIP_GC-B_Human1.24512016
90TET1_21490601_ChIP-Seq_MESCs_Mouse1.23913467
91UTX_26944678_Chip-Seq_JUKART_Human1.23515347
92RUNX1_22412390_ChIP-Seq_EML_Mouse1.21882051
93TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.21365703
94SPI1_23127762_ChIP-Seq_K562_Human1.21014372
95CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.18966286
96SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.18365729
97ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.17835715
98EGR1_19374776_ChIP-ChIP_THP-1_Human1.15278770
99TAF15_26573619_Chip-Seq_HEK293_Human1.15207420
100RARG_19884340_ChIP-ChIP_MEFs_Mouse1.14594561
101SOX2_21211035_ChIP-Seq_LN229_Gbm1.14546791
102CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.14148124
103OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.13225755
104NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.12760432
105RUNX1_27514584_Chip-Seq_MCF-7_Human1.12543534
106CDX2_19796622_ChIP-Seq_MESCs_Mouse1.12403921
107PU.1_20513432_ChIP-Seq_Bcells_Mouse1.11824866
108RING1B_27294783_Chip-Seq_ESCs_Mouse1.11505352
109ZFP281_27345836_Chip-Seq_ESCs_Mouse1.10851364
110* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.09942696
111TP63_22573176_ChIP-Seq_HFKS_Human1.09075092
112CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.08448681
113BP1_19119308_ChIP-ChIP_Hs578T_Human1.07840569
114* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.07612454
115AR_21572438_ChIP-Seq_LNCaP_Human1.07537032
116AR_19668381_ChIP-Seq_PC3_Human1.07358764
117RXR_22158963_ChIP-Seq_LIVER_Mouse1.07114950
118SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.07053126
119GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06478179
120NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.06360824
121SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.06104803
122* FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.05815016
123* OCT4_19829295_ChIP-Seq_ESCs_Human1.04015972
124KDM2B_26808549_Chip-Seq_DND41_Human1.03936156
125CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.03131384
126ARNT_22903824_ChIP-Seq_MCF-7_Human1.03082846
127* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.02450751
128TP53_22127205_ChIP-Seq_IMR90_Human1.02269776
129GATA1_22383799_ChIP-Seq_G1ME_Mouse1.00893069
130JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.00521908
131SMAD4_21799915_ChIP-Seq_A2780_Human1.00325111
132CTCF_26484167_Chip-Seq_Bcells_Mouse0.99949312
133ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.99543717
134NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.99162510
135SCL_19346495_ChIP-Seq_HPC-7_Human0.98872966
136RARB_24833708_ChIP-Seq_LIVER_Mouse0.98835854
137SMAD4_21741376_ChIP-Seq_HESCs_Human0.98622983
138RARA_24833708_ChIP-Seq_LIVER_Mouse0.98504353
139* PHF8_20622854_ChIP-Seq_HELA_Human0.98343699
140SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.98034963
141GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.97518708
142ZNF217_24962896_ChIP-Seq_MCF-7_Human0.97233664
143MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.96493416
144LXR_22158963_ChIP-Seq_LIVER_Mouse0.96010113
145PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.94683485
146EP300_21415370_ChIP-Seq_HL-1_Mouse0.94080850
147P300_27058665_Chip-Seq_ZR-75-30cells_Human0.94067692
148SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.92470782
149DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.91765139
150FOXA2_19822575_ChIP-Seq_HepG2_Human0.91424795
151SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91133037
152CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.88472628
153PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.87844579
154RING1B_27294783_Chip-Seq_NPCs_Mouse0.87270679
155TP53_20018659_ChIP-ChIP_R1E_Mouse0.87241627
156TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.87033962
157KLF4_19829295_ChIP-Seq_ESCs_Human0.86520024
158ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.85494908
159CREB1_26743006_Chip-Seq_LNCaP_Human0.84691285
160RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.84449572
161* SMC4_20622854_ChIP-Seq_HELA_Human0.84127184
162PPARA_22158963_ChIP-Seq_LIVER_Mouse0.83149979
163EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.83065367
164SMAD3_21741376_ChIP-Seq_ESCs_Human0.82863158
165CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.82761784
166RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.82672329
167CTBP2_25329375_ChIP-Seq_LNCAP_Human0.80910436

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.36274984
2MP0004858_abnormal_nervous_system4.04335345
3MP0002735_abnormal_chemical_nociception3.91944819
4MP0008260_abnormal_autophagy3.91482490
5MP0004270_analgesia3.72763104
6MP0001968_abnormal_touch/_nociception3.60240499
7MP0005058_abnormal_lysosome_morphology3.43992753
8MP0003303_peritoneal_inflammation3.42055403
9MP0002736_abnormal_nociception_after3.21337884
10MP0009278_abnormal_bone_marrow3.13348762
11MP0003436_decreased_susceptibility_to3.06575907
12MP0002733_abnormal_thermal_nociception2.86255169
13MP0002734_abnormal_mechanical_nocicepti2.85734667
14MP0006276_abnormal_autonomic_nervous2.83054360
15MP0003635_abnormal_synaptic_transmissio2.80487191
16MP0003191_abnormal_cellular_cholesterol2.64706468
17MP0003329_amyloid_beta_deposits2.42504764
18MP0005451_abnormal_body_composition2.42112202
19MP0002837_dystrophic_cardiac_calcinosis2.33447206
20MP0001970_abnormal_pain_threshold2.30278431
21MP0009046_muscle_twitch2.18977812
22MP0000569_abnormal_digit_pigmentation2.18522355
23MP0000751_myopathy2.17084133
24MP0003880_abnormal_central_pattern2.14634986
25MP0002184_abnormal_innervation2.09230349
26MP0002063_abnormal_learning/memory/cond2.08191685
27MP0002909_abnormal_adrenal_gland2.07962513
28MP0002064_seizures2.07182384
29MP0004510_myositis1.97760054
30MP0002272_abnormal_nervous_system1.96645775
31MP0001545_abnormal_hematopoietic_system1.87147691
32MP0005397_hematopoietic_system_phenotyp1.87147691
33MP0005076_abnormal_cell_differentiation1.87007308
34MP0009745_abnormal_behavioral_response1.81468046
35MP0000955_abnormal_spinal_cord1.80188444
36MP0004811_abnormal_neuron_physiology1.78264315
37MP0005083_abnormal_biliary_tract1.77645360
38MP0002067_abnormal_sensory_capabilities1.69488826
39MP0002822_catalepsy1.61585561
40MP0009780_abnormal_chondrocyte_physiolo1.61203011
41MP0000778_abnormal_nervous_system1.58726523
42MP0002572_abnormal_emotion/affect_behav1.57760383
43MP0005423_abnormal_somatic_nervous1.54583754
44MP0001440_abnormal_grooming_behavior1.52360027
45MP0005025_abnormal_response_to1.45554793
46MP0000747_muscle_weakness1.43398792
47MP0000604_amyloidosis1.41236680
48MP0005645_abnormal_hypothalamus_physiol1.40428703
49MP0001984_abnormal_olfaction1.39117388
50MP0003724_increased_susceptibility_to1.36974583
51MP0002139_abnormal_hepatobiliary_system1.36189265
52MP0002882_abnormal_neuron_morphology1.33984999
53MP0008961_abnormal_basal_metabolism1.32631456
54MP0001486_abnormal_startle_reflex1.31539739
55MP0004130_abnormal_muscle_cell1.29611144
56MP0002419_abnormal_innate_immunity1.28231498
57MP0003633_abnormal_nervous_system1.27954794
58MP0003453_abnormal_keratinocyte_physiol1.26673041
59MP0003075_altered_response_to1.25269503
60MP0004185_abnormal_adipocyte_glucose1.25163368
61MP0004947_skin_inflammation1.24488544
62MP0003634_abnormal_glial_cell1.24303134
63MP0008569_lethality_at_weaning1.23914325
64MP0005409_darkened_coat_color1.23023262
65MP0000920_abnormal_myelination1.19271739
66MP0002269_muscular_atrophy1.18674465
67MP0005623_abnormal_meninges_morphology1.18488033
68MP0002332_abnormal_exercise_endurance1.18096676
69MP0004924_abnormal_behavior1.17605428
70MP0005386_behavior/neurological_phenoty1.17605428
71MP0003172_abnormal_lysosome_physiology1.17551377
72MP0002066_abnormal_motor_capabilities/c1.16806891
73MP0002751_abnormal_autonomic_nervous1.15801018
74MP0001849_ear_inflammation1.14627161
75MP0005666_abnormal_adipose_tissue1.14324760
76MP0005360_urolithiasis1.14310978
77MP0002557_abnormal_social/conspecific_i1.14305533
78MP0003705_abnormal_hypodermis_morpholog1.13417293
79MP0005000_abnormal_immune_tolerance1.12853942
80MP0001533_abnormal_skeleton_physiology1.12098201
81MP0004084_abnormal_cardiac_muscle1.11290887
82MP0003300_gastrointestinal_ulcer1.09670815
83MP0005375_adipose_tissue_phenotype1.07179845
84MP0003631_nervous_system_phenotype1.05809436
85MP0004036_abnormal_muscle_relaxation1.05694174
86MP0002229_neurodegeneration1.05276134
87MP0005499_abnormal_olfactory_system1.05054329
88MP0005394_taste/olfaction_phenotype1.05054329
89MP0004145_abnormal_muscle_electrophysio1.04695434
90MP0000858_altered_metastatic_potential1.04568672
91MP0009840_abnormal_foam_cell1.01830884
92MP0001299_abnormal_eye_distance/1.01480786
93MP0005464_abnormal_platelet_physiology1.00377989
94MP0010329_abnormal_lipoprotein_level0.99844964
95MP0005310_abnormal_salivary_gland0.98367729
96MP0001501_abnormal_sleep_pattern0.98065715
97MP0002723_abnormal_immune_serum0.97336768
98MP0000749_muscle_degeneration0.96193026
99MP0004233_abnormal_muscle_weight0.94099272
100MP0005330_cardiomyopathy0.93276335
101MP0004742_abnormal_vestibular_system0.92834889
102MP0001790_abnormal_immune_system0.91375448
103MP0005387_immune_system_phenotype0.91375448
104MP0008874_decreased_physiological_sensi0.90930355
105MP0002796_impaired_skin_barrier0.90303552
106MP0005670_abnormal_white_adipose0.89503239
107MP0005085_abnormal_gallbladder_physiolo0.89363856
108MP0003137_abnormal_impulse_conducting0.88892742
109MP0003091_abnormal_cell_migration0.88674903
110MP0003183_abnormal_peptide_metabolism0.88275515
111MP0001348_abnormal_lacrimal_gland0.87902318
112MP0002653_abnormal_ependyma_morphology0.87473755
113MP0004142_abnormal_muscle_tone0.87003319
114MP0002420_abnormal_adaptive_immunity0.86928788
115MP0001800_abnormal_humoral_immune0.86797883
116MP0001819_abnormal_immune_cell0.86522834
117MP0004085_abnormal_heartbeat0.86085997
118MP0000534_abnormal_ureter_morphology0.84616805
119MP0002152_abnormal_brain_morphology0.83531762
120MP0003879_abnormal_hair_cell0.83252750
121MP0005365_abnormal_bile_salt0.82739723
122MP0003787_abnormal_imprinting0.82614671
123MP0003045_fibrosis0.81456976
124MP0000750_abnormal_muscle_regeneration0.81402907
125MP0005535_abnormal_body_temperature0.81393272
126MP0004215_abnormal_myocardial_fiber0.81251855
127MP0002148_abnormal_hypersensitivity_rea0.81050325
128MP0002752_abnormal_somatic_nervous0.80411938
129MP0010234_abnormal_vibrissa_follicle0.78678983
130MP0000013_abnormal_adipose_tissue0.78566462
131MP0010630_abnormal_cardiac_muscle0.78237672
132MP0005167_abnormal_blood-brain_barrier0.78089608
133MP0003656_abnormal_erythrocyte_physiolo0.77555224
134MP0003632_abnormal_nervous_system0.76846219
135MP0004381_abnormal_hair_follicle0.76412430
136MP0002452_abnormal_antigen_presenting0.75032547
137MP0003122_maternal_imprinting0.73776507
138MP0003806_abnormal_nucleotide_metabolis0.73361259
139MP0000759_abnormal_skeletal_muscle0.73117367
140MP0005501_abnormal_skin_physiology0.73075318
141MP0004087_abnormal_muscle_fiber0.72295478
142MP0005621_abnormal_cell_physiology0.72231397
143MP0002069_abnormal_eating/drinking_beha0.71905186
144MP0001502_abnormal_circadian_rhythm0.69899675
145MP0003690_abnormal_glial_cell0.69079834
146MP0010386_abnormal_urinary_bladder0.69040503
147MP0001270_distended_abdomen0.68490008
148MP0002972_abnormal_cardiac_muscle0.68163152
149MP0000003_abnormal_adipose_tissue0.67496193
150MP0002118_abnormal_lipid_homeostasis0.67435224
151MP0002090_abnormal_vision0.67340442
152MP0000678_abnormal_parathyroid_gland0.67090319
153MP0004264_abnormal_extraembryonic_tissu0.66957307
154MP0000685_abnormal_immune_system0.66774664
155MP0008872_abnormal_physiological_respon0.66464071
156MP0009931_abnormal_skin_appearance0.66440551
157MP0003566_abnormal_cell_adhesion0.66225120
158MP0000716_abnormal_immune_system0.65368516
159MP0001835_abnormal_antigen_presentation0.64323925
160MP0000681_abnormal_thyroid_gland0.62329151

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)5.38430718
2Supranuclear gaze palsy (HP:0000605)4.47386012
3Ulnar claw (HP:0001178)4.02173268
4Pheochromocytoma (HP:0002666)3.92631115
5Action tremor (HP:0002345)3.87916971
6Focal seizures (HP:0007359)3.84374161
7Visual hallucinations (HP:0002367)3.48652381
8Ankle clonus (HP:0011448)3.45930192
9Insidious onset (HP:0003587)3.42411877
10Termporal pattern (HP:0011008)3.42411877
11Neuroendocrine neoplasm (HP:0100634)3.38693634
12Difficulty climbing stairs (HP:0003551)3.28535817
13Abnormality of the lower motor neuron (HP:0002366)3.25904802
14Focal motor seizures (HP:0011153)3.21953444
15Hyporeflexia of lower limbs (HP:0002600)3.07516892
16Abnormality of pain sensation (HP:0010832)2.92251606
17Impaired pain sensation (HP:0007328)2.92251606
18Cerebral aneurysm (HP:0004944)2.88254413
19Urinary urgency (HP:0000012)2.87958022
20Loss of speech (HP:0002371)2.86684978
21Limb dystonia (HP:0002451)2.81776858
22Hypercortisolism (HP:0001578)2.77603740
23Eczematoid dermatitis (HP:0000976)2.72061228
24Atonic seizures (HP:0010819)2.70591344
25Cerebral inclusion bodies (HP:0100314)2.65198922
26Febrile seizures (HP:0002373)2.61360245
27Urinary bladder sphincter dysfunction (HP:0002839)2.60072508
28Absence seizures (HP:0002121)2.59236959
29Generalized tonic-clonic seizures (HP:0002069)2.56439879
30Ragged-red muscle fibers (HP:0003200)2.55951526
31Truncal ataxia (HP:0002078)2.55535539
32Rapidly progressive (HP:0003678)2.55053524
33Microvesicular hepatic steatosis (HP:0001414)2.53058797
34Progressive cerebellar ataxia (HP:0002073)2.51183194
35Diminished motivation (HP:0000745)2.50179212
36Distal lower limb amyotrophy (HP:0008944)2.49838120
37Failure to thrive in infancy (HP:0001531)2.49244629
38Hypoventilation (HP:0002791)2.47792605
39Abnormality of the corticospinal tract (HP:0002492)2.47595735
40Myotonia (HP:0002486)2.47569009
41Postural instability (HP:0002172)2.47507553
42Abnormality of glycolipid metabolism (HP:0010969)2.46661947
43Abnormality of liposaccharide metabolism (HP:0010968)2.46661947
44Abnormality of glycosphingolipid metabolism (HP:0004343)2.46661947
45Ventricular fibrillation (HP:0001663)2.44671222
46Insomnia (HP:0100785)2.44274582
47Neurofibrillary tangles (HP:0002185)2.43795379
48J-shaped sella turcica (HP:0002680)2.43205162
49Apathy (HP:0000741)2.42649616
50Dysostosis multiplex (HP:0000943)2.41238622
51Anosmia (HP:0000458)2.41125083
52Hand muscle atrophy (HP:0009130)2.39308764
53Upper limb amyotrophy (HP:0009129)2.38514339
54Distal upper limb amyotrophy (HP:0007149)2.38514339
55* Hammertoe (HP:0001765)2.38228267
56Spastic gait (HP:0002064)2.38080467
57Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.37446196
58Distal lower limb muscle weakness (HP:0009053)2.37285223
59Lower limb muscle weakness (HP:0007340)2.36173747
60Depression (HP:0000716)2.34669323
61Dialeptic seizures (HP:0011146)2.32564562
62Broad face (HP:0000283)2.31259591
63Decreased number of peripheral myelinated nerve fibers (HP:0003380)2.30750350
64Torticollis (HP:0000473)2.30109128
65Axonal loss (HP:0003447)2.29721568
66Onion bulb formation (HP:0003383)2.29411729
67Increased cerebral lipofuscin (HP:0011813)2.27839514
68Cellulitis (HP:0100658)2.25878858
69Epileptic encephalopathy (HP:0200134)2.24818128
70Abnormality of macrophages (HP:0004311)2.24130374
71Peripheral hypomyelination (HP:0007182)2.22138460
72Amblyopia (HP:0000646)2.20431762
73Thin bony cortex (HP:0002753)2.20357939
74Abnormality of mucopolysaccharide metabolism (HP:0011020)2.20119688
75Abnormality of polysaccharide metabolism (HP:0011012)2.20119688
76Abnormality of glycosaminoglycan metabolism (HP:0004371)2.20119688
77Recurrent bacterial skin infections (HP:0005406)2.19562499
78* Distal sensory impairment (HP:0002936)2.19398008
79Sudden death (HP:0001699)2.16506789
80Gingivitis (HP:0000230)2.15515426
81Morphological abnormality of the pyramidal tract (HP:0002062)2.15259248
82Difficulty running (HP:0009046)2.15236390
83Mucopolysacchariduria (HP:0008155)2.14677984
84Urinary glycosaminoglycan excretion (HP:0003541)2.14677984
85Centrally nucleated skeletal muscle fibers (HP:0003687)2.14337314
86Status epilepticus (HP:0002133)2.13922994
87Increased connective tissue (HP:0009025)2.12780776
88* Foot dorsiflexor weakness (HP:0009027)2.11918370
89EMG: neuropathic changes (HP:0003445)2.11659259
90Obstructive sleep apnea (HP:0002870)2.09122923
91Neoplasm of the peripheral nervous system (HP:0100007)2.08256594
92Spastic paraplegia (HP:0001258)2.07946154
93Segmental peripheral demyelination/remyelination (HP:0003481)2.07563837
94Impaired vibration sensation in the lower limbs (HP:0002166)2.06505012
95Growth hormone excess (HP:0000845)2.05691140
96Abnormality of the vocal cords (HP:0008777)2.05297385
97Postural tremor (HP:0002174)2.05182274
98Cholecystitis (HP:0001082)2.05047705
99Abnormal gallbladder physiology (HP:0012438)2.05047705
100Recurrent abscess formation (HP:0002722)2.03807481
101Clonus (HP:0002169)2.03627745
102Neonatal onset (HP:0003623)2.03446511
103Paraplegia (HP:0010550)2.00932009
104Steppage gait (HP:0003376)2.00839730
105Decreased motor nerve conduction velocity (HP:0003431)1.98082831
106Hemorrhage of the eye (HP:0011885)1.97122242
107Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.97013263
108Abnormal eating behavior (HP:0100738)1.96387256
109Increased IgE level (HP:0003212)1.95931620
110Craniofacial dystonia (HP:0012179)1.95203289
111Bradykinesia (HP:0002067)1.95157552
112Bundle branch block (HP:0011710)1.94049513
113Obstructive lung disease (HP:0006536)1.93493442
114Chronic obstructive pulmonary disease (HP:0006510)1.93493442
115Reticulocytosis (HP:0001923)1.93449158
116Upper motor neuron abnormality (HP:0002127)1.92538749
117Asymmetric septal hypertrophy (HP:0001670)1.92529723
118Focal dystonia (HP:0004373)1.92096872
119Amyotrophic lateral sclerosis (HP:0007354)1.92026323
120Hyperacusis (HP:0010780)1.91600373
121Impaired social interactions (HP:0000735)1.91371505
122Abnormal social behavior (HP:0012433)1.91371505
123* Abnormality of the foot musculature (HP:0001436)1.91357471
124Hypoplasia of the brainstem (HP:0002365)1.91140067
125Aplasia/Hypoplasia of the brainstem (HP:0007362)1.91140067
126Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.90918033
127Interstitial pulmonary disease (HP:0006530)1.90337890
128Mutism (HP:0002300)1.88065177
129Pointed chin (HP:0000307)1.87719891
130Neuronal loss in central nervous system (HP:0002529)1.87254613
131Prolonged QT interval (HP:0001657)1.87061606
132Nuclear cataract (HP:0100018)1.86437300
133Dysdiadochokinesis (HP:0002075)1.85183277
134Rigidity (HP:0002063)1.83925304
135Amyloidosis (HP:0011034)1.83719140
136Papilledema (HP:0001085)1.83241324
137Anomalous pulmonary venous return (HP:0010772)1.83062687
138Abnormality of the Achilles tendon (HP:0005109)1.81333606
139Dysmetria (HP:0001310)1.81326360
140Lower limb amyotrophy (HP:0007210)1.81216533
141Syncope (HP:0001279)1.80265114
142Increased serum ferritin (HP:0003281)1.79506806
143Hypsarrhythmia (HP:0002521)1.79260444
144Easy fatigability (HP:0003388)1.78749055
145Exotropia (HP:0000577)1.78571472
146Hypothermia (HP:0002045)1.78524891
147Achilles tendon contracture (HP:0001771)1.78075794
148Recurrent gram-negative bacterial infections (HP:0005420)1.78070950
149Dysautonomia (HP:0002459)1.77671682
150Metaphyseal cupping (HP:0003021)1.77547981
151Deep venous thrombosis (HP:0002625)1.77125233
152Hypertensive crisis (HP:0100735)1.77081583
153Abnormal EKG (HP:0003115)1.76675856
154EEG with generalized epileptiform discharges (HP:0011198)1.76076037
155Stridor (HP:0010307)1.75868530
156Mask-like facies (HP:0000298)1.74354577
157Flat acetabular roof (HP:0003180)1.74228263
158Anxiety (HP:0000739)1.73303797
159Hemiplegia (HP:0002301)1.72697301
160Exercise-induced myalgia (HP:0003738)1.72686951
161Myositis (HP:0100614)1.71995017
162Increased neuronal autofluorescent lipopigment (HP:0002074)1.71796261
163Gastrointestinal inflammation (HP:0004386)1.71509514
164Bowel incontinence (HP:0002607)1.71239929
165Hyperthyroidism (HP:0000836)1.67560230
166Progressive muscle weakness (HP:0003323)1.67554761
167Colitis (HP:0002583)1.66088893
168Long palpebral fissure (HP:0000637)1.65985658
169Ventricular tachycardia (HP:0004756)1.65023461
170Slow saccadic eye movements (HP:0000514)1.64789121

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK13.70245725
2MAP3K93.61033919
3LMTK22.98815761
4MINK12.95405313
5NTRK32.91345184
6MARK12.65213094
7MAPKAPK32.50640501
8ERN12.50556927
9MAP3K112.48913153
10PRPF4B2.46615029
11KSR22.41009052
12MAP3K42.36818722
13PHKG12.35972582
14PHKG22.35972582
15LATS22.25711670
16MAP2K32.18446059
17MAP3K22.04742912
18SMG12.04482055
19MAP2K41.98994701
20PAK61.89703496
21DAPK21.84656438
22TNK21.81635265
23NTRK21.71324707
24EPHB11.68920812
25KSR11.63491319
26PRKD21.56748691
27EEF2K1.56393547
28MAP4K11.54546527
29IRAK31.52481535
30PRKD31.52317122
31RET1.51774023
32TRIB31.47202824
33CAMKK11.40462482
34GRK51.36397977
35LIMK11.35062780
36SCYL21.27798215
37CDK121.26152549
38ICK1.24354777
39SGK2231.24125916
40SGK4941.24125916
41STK381.23933259
42TBK11.23217736
43TESK11.18604786
44MAPK131.16243405
45TAOK21.15681405
46SGK31.12665968
47CAMK1G1.11818316
48NEK11.11106265
49CDK51.09474687
50PAK31.09410134
51CAMKK21.09370273
52MAP2K71.09078762
53NME21.08433982
54RPS6KA21.06073817
55FGFR41.05423826
56DYRK1B1.02865276
57PIM21.02296332
58TESK21.00856755
59SGK20.99058198
60FER0.94509036
61MAP2K10.93617682
62MAP3K60.93040134
63EPHA40.92434985
64BLK0.90901445
65RPS6KC10.89710994
66RPS6KL10.89710994
67WNK10.87438533
68SIK10.86613273
69UHMK10.86549326
70SIK30.85531437
71CAMK1D0.85403222
72JAK30.81389882
73ARAF0.80305596
74MAP3K30.79393117
75PRKCG0.78045933
76PKN20.77415691
77MAP3K120.77300781
78PDK40.75016090
79PDK30.75016090
80MAP3K130.74991512
81MATK0.74245059
82TTN0.73750603
83TYRO30.69921786
84MARK20.69327263
85EPHA20.69240273
86RIPK10.69108045
87PTK20.68936944
88ALK0.68637693
89FES0.68578062
90CSNK1G20.68400043
91PDGFRA0.68302508
92HIPK20.67651559
93DAPK10.67203552
94CDK140.66876933
95MAPK110.66390047
96CDK180.65876712
97PRKCH0.65553301
98RPS6KA60.64447954
99PRKCZ0.63996203
100CSK0.63854052
101EPHB20.62480727
102TAOK10.62358678
103STK110.62231995
104RIPK40.61571462
105TYK20.61484271
106ZAP700.60984447
107MAP3K50.60474423
108MAP3K10.60179050
109MAP3K70.59552716
110JAK20.59496166
111CDK150.59151758
112FGR0.58184692
113CDC42BPA0.58100553
114GRK60.57537383
115MAPKAPK50.56756612
116ERBB20.56461938
117IRAK20.55795019
118PNCK0.55533751
119PTK60.55449118
120MAP3K100.54761615
121IRAK40.54554742
122EPHA30.54105545
123SIK20.52612424
124FYN0.51560195
125CAMK2A0.51207863
126MAPK40.51118793
127MAP2K60.50224739
128MAPK120.50186391
129MAP2K20.49568256
130CSF1R0.48112268
131PDPK10.47813320
132PTK2B0.46247937
133CAMK2B0.46169849
134MAPK70.46083105
135CDK11A0.45554480
136ROCK10.45344966
137MTOR0.44123656
138WNK40.43770269
139ADRBK10.42799840
140PRKAA10.40257997
141DDR20.39802253
142ROCK20.38936147
143CAMK2G0.38822169
144MAPK100.38363366
145DAPK30.37605987
146CAMK40.37178948
147PRKD10.37152644
148CSNK1G30.36870636
149BMX0.36374736
150PDK10.36117630

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005113.31432559
2Synaptic vesicle cycle_Homo sapiens_hsa047212.91583559
3Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.47268945
4Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.28340968
5Olfactory transduction_Homo sapiens_hsa047402.13430782
6Nitrogen metabolism_Homo sapiens_hsa009102.11481644
7Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.95281277
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.93920234
9Glycosaminoglycan degradation_Homo sapiens_hsa005311.72951784
10Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.64610846
11Notch signaling pathway_Homo sapiens_hsa043301.63006575
12Dopaminergic synapse_Homo sapiens_hsa047281.56732792
13Acute myeloid leukemia_Homo sapiens_hsa052211.54375722
14Circadian entrainment_Homo sapiens_hsa047131.52960894
15Insulin secretion_Homo sapiens_hsa049111.51335281
16Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.49834996
17Osteoclast differentiation_Homo sapiens_hsa043801.47478187
18GABAergic synapse_Homo sapiens_hsa047271.46739961
19Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.44987483
20Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.41121375
21Arginine biosynthesis_Homo sapiens_hsa002201.39680332
22Long-term potentiation_Homo sapiens_hsa047201.37635174
23Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.35632302
24Cholinergic synapse_Homo sapiens_hsa047251.34289377
25Salivary secretion_Homo sapiens_hsa049701.33935079
26Toll-like receptor signaling pathway_Homo sapiens_hsa046201.32601709
27Bile secretion_Homo sapiens_hsa049761.31997226
28Gastric acid secretion_Homo sapiens_hsa049711.31851654
29B cell receptor signaling pathway_Homo sapiens_hsa046621.30452232
30Lysosome_Homo sapiens_hsa041421.29214701
31Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.27996361
32Glutamatergic synapse_Homo sapiens_hsa047241.27835784
33Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.27492940
34Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.26761408
35Butanoate metabolism_Homo sapiens_hsa006501.26311717
36Nicotine addiction_Homo sapiens_hsa050331.24025219
37Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.21326465
38GnRH signaling pathway_Homo sapiens_hsa049121.20833817
39Amphetamine addiction_Homo sapiens_hsa050311.19929234
40Chronic myeloid leukemia_Homo sapiens_hsa052201.18964287
41Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.17946525
422-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.17449973
43Type II diabetes mellitus_Homo sapiens_hsa049301.17167266
44Inositol phosphate metabolism_Homo sapiens_hsa005621.16412548
45Glioma_Homo sapiens_hsa052141.14599466
46Aldosterone synthesis and secretion_Homo sapiens_hsa049251.13578631
47Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.11573906
48Leishmaniasis_Homo sapiens_hsa051401.11487062
49Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.11391314
50Morphine addiction_Homo sapiens_hsa050321.11102264
51Insulin signaling pathway_Homo sapiens_hsa049101.10817487
52Pentose phosphate pathway_Homo sapiens_hsa000301.07354115
53Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.07329084
54Dorso-ventral axis formation_Homo sapiens_hsa043201.06986253
55Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.06268626
56Collecting duct acid secretion_Homo sapiens_hsa049661.05357610
57Gap junction_Homo sapiens_hsa045401.05328165
58Fructose and mannose metabolism_Homo sapiens_hsa000511.04822914
59Taste transduction_Homo sapiens_hsa047421.04009638
60Estrogen signaling pathway_Homo sapiens_hsa049151.04007413
61Neurotrophin signaling pathway_Homo sapiens_hsa047221.03302520
62Tuberculosis_Homo sapiens_hsa051521.02400294
63Fatty acid metabolism_Homo sapiens_hsa012121.01964678
64RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.01244617
65Renin secretion_Homo sapiens_hsa049240.98210748
66Pyruvate metabolism_Homo sapiens_hsa006200.96550895
67Oxytocin signaling pathway_Homo sapiens_hsa049210.96247139
68Primary bile acid biosynthesis_Homo sapiens_hsa001200.96073140
69Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.96033644
70Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.95053152
71Cocaine addiction_Homo sapiens_hsa050300.92618816
72Salmonella infection_Homo sapiens_hsa051320.92308436
73ErbB signaling pathway_Homo sapiens_hsa040120.91390377
74Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.91212886
75TNF signaling pathway_Homo sapiens_hsa046680.90187265
76Phosphatidylinositol signaling system_Homo sapiens_hsa040700.89886457
77Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.88556979
78Hepatitis C_Homo sapiens_hsa051600.88260264
79Axon guidance_Homo sapiens_hsa043600.87807488
80Glucagon signaling pathway_Homo sapiens_hsa049220.87753172
81Fatty acid biosynthesis_Homo sapiens_hsa000610.86599436
82Fatty acid degradation_Homo sapiens_hsa000710.85786640
83AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.83715383
84Toxoplasmosis_Homo sapiens_hsa051450.83304055
85Amoebiasis_Homo sapiens_hsa051460.81127551
86Central carbon metabolism in cancer_Homo sapiens_hsa052300.80541471
87Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.79584992
88Long-term depression_Homo sapiens_hsa047300.77914729
89Propanoate metabolism_Homo sapiens_hsa006400.77802290
90Influenza A_Homo sapiens_hsa051640.77694971
91Chemokine signaling pathway_Homo sapiens_hsa040620.76998259
92Serotonergic synapse_Homo sapiens_hsa047260.75462899
93Pancreatic cancer_Homo sapiens_hsa052120.75239541
94Melanogenesis_Homo sapiens_hsa049160.75122371
95Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.75057165
96Shigellosis_Homo sapiens_hsa051310.74936925
97Hepatitis B_Homo sapiens_hsa051610.74838401
98Prion diseases_Homo sapiens_hsa050200.73624819
99Calcium signaling pathway_Homo sapiens_hsa040200.73493919
100Vibrio cholerae infection_Homo sapiens_hsa051100.73447616
101MAPK signaling pathway_Homo sapiens_hsa040100.72937386
102mTOR signaling pathway_Homo sapiens_hsa041500.72752900
103Leukocyte transendothelial migration_Homo sapiens_hsa046700.70680055
104Staphylococcus aureus infection_Homo sapiens_hsa051500.70536105
105Phospholipase D signaling pathway_Homo sapiens_hsa040720.70179142
106Endometrial cancer_Homo sapiens_hsa052130.70046061
107PPAR signaling pathway_Homo sapiens_hsa033200.69799600
108Dilated cardiomyopathy_Homo sapiens_hsa054140.69130500
109Cardiac muscle contraction_Homo sapiens_hsa042600.69007331
110Tryptophan metabolism_Homo sapiens_hsa003800.68467816
111Platelet activation_Homo sapiens_hsa046110.67434722
112Carbohydrate digestion and absorption_Homo sapiens_hsa049730.66985656
113VEGF signaling pathway_Homo sapiens_hsa043700.66659964
114cAMP signaling pathway_Homo sapiens_hsa040240.64933929
115Thyroid hormone synthesis_Homo sapiens_hsa049180.64926825
116Thyroid hormone signaling pathway_Homo sapiens_hsa049190.64544604
117Phagosome_Homo sapiens_hsa041450.63779147
118Pertussis_Homo sapiens_hsa051330.62810783
119cGMP-PKG signaling pathway_Homo sapiens_hsa040220.62363858
120Bladder cancer_Homo sapiens_hsa052190.61678177
121Insulin resistance_Homo sapiens_hsa049310.61281455
122Sulfur relay system_Homo sapiens_hsa041220.61134312
123Glycerolipid metabolism_Homo sapiens_hsa005610.59417384
124Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.58369316
125Endocytosis_Homo sapiens_hsa041440.58082915
126Vascular smooth muscle contraction_Homo sapiens_hsa042700.57510124
127Galactose metabolism_Homo sapiens_hsa000520.57058447
128T cell receptor signaling pathway_Homo sapiens_hsa046600.56508444
129Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.54506242
130Adipocytokine signaling pathway_Homo sapiens_hsa049200.53376694
131Apoptosis_Homo sapiens_hsa042100.53044582
132Glycerophospholipid metabolism_Homo sapiens_hsa005640.52638147
133Carbon metabolism_Homo sapiens_hsa012000.52612350
134Measles_Homo sapiens_hsa051620.51580096
135Oocyte meiosis_Homo sapiens_hsa041140.51102017
136AMPK signaling pathway_Homo sapiens_hsa041520.50968663
137Non-small cell lung cancer_Homo sapiens_hsa052230.50104932
138Prolactin signaling pathway_Homo sapiens_hsa049170.47175175
139Longevity regulating pathway - mammal_Homo sapiens_hsa042110.46361945
140Sphingolipid signaling pathway_Homo sapiens_hsa040710.45292788
141Renal cell carcinoma_Homo sapiens_hsa052110.44414602
142Choline metabolism in cancer_Homo sapiens_hsa052310.43350386
143Phenylalanine metabolism_Homo sapiens_hsa003600.41990416
144Rap1 signaling pathway_Homo sapiens_hsa040150.41259216
145Tyrosine metabolism_Homo sapiens_hsa003500.41101508
146Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.40639287

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »