LRTM1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1detection of light stimulus involved in sensory perception (GO:0050962)7.47546223
2detection of light stimulus involved in visual perception (GO:0050908)7.47546223
3negative regulation of cytosolic calcium ion concentration (GO:0051481)7.37537310
4cardiac myofibril assembly (GO:0055003)6.63105426
5regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO6.59651709
6regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)6.23564549
7regulation of sarcomere organization (GO:0060297)6.16172733
8retinal rod cell development (GO:0046548)6.09352719
9regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)5.81609219
10myofibril assembly (GO:0030239)5.74855201
11positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)5.63814133
12cell communication by electrical coupling involved in cardiac conduction (GO:0086064)5.62208392
13sarcomere organization (GO:0045214)5.60683632
14regulation of relaxation of muscle (GO:1901077)5.56875955
15retinal cone cell development (GO:0046549)5.30713252
16regulation of cell communication by electrical coupling (GO:0010649)5.16765559
17behavioral response to nicotine (GO:0035095)5.12930504
18potassium ion export (GO:0071435)5.09184566
19cardiac muscle contraction (GO:0060048)5.09027671
20regulation of actin filament-based movement (GO:1903115)4.94165071
21DNA deamination (GO:0045006)4.94119435
22response to pheromone (GO:0019236)4.79311945
23cell communication by electrical coupling (GO:0010644)4.69469300
24negative regulation of potassium ion transmembrane transport (GO:1901380)4.66827641
25regulation of membrane repolarization (GO:0060306)4.54389968
26ventricular cardiac muscle cell action potential (GO:0086005)4.51168459
27cell communication involved in cardiac conduction (GO:0086065)4.43495411
28G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.37380410
29regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.36651056
30regulation of skeletal muscle contraction (GO:0014819)4.33109351
31water-soluble vitamin biosynthetic process (GO:0042364)4.31360329
32negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.30860892
33cellular potassium ion homeostasis (GO:0030007)4.25216967
34regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.22463533
35sarcoplasmic reticulum calcium ion transport (GO:0070296)4.21476314
36ventricular cardiac muscle tissue morphogenesis (GO:0055010)4.17000963
37cardiac muscle cell development (GO:0055013)4.15263278
38potassium ion homeostasis (GO:0055075)4.15032795
39urinary tract smooth muscle contraction (GO:0014848)4.14179042
40regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.04967742
41cardiac muscle tissue morphogenesis (GO:0055008)4.04605296
42regulation of bile acid biosynthetic process (GO:0070857)4.04422253
43eye photoreceptor cell development (GO:0042462)4.02356870
44bundle of His cell to Purkinje myocyte communication (GO:0086069)3.99969121
45relaxation of smooth muscle (GO:0044557)3.99216648
46photoreceptor cell development (GO:0042461)3.98999249
47muscle filament sliding (GO:0030049)3.98866146
48actin-myosin filament sliding (GO:0033275)3.98866146
49regulation of cardiac muscle cell contraction (GO:0086004)3.97738473
50striated muscle contraction (GO:0006941)3.97270253
51adult heart development (GO:0007512)3.93322798
52regulation of striated muscle contraction (GO:0006942)3.89048258
53cardiac cell development (GO:0055006)3.87775266
54rhodopsin mediated signaling pathway (GO:0016056)3.86332020
55regulation of the force of heart contraction (GO:0002026)3.84725057
56tricarboxylic acid cycle (GO:0006099)3.76690375
57cardiac muscle cell action potential (GO:0086001)3.76446160
58desmosome organization (GO:0002934)3.71435618
59peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.70574940
60regulation of cardiac muscle contraction (GO:0055117)3.70125772
61cardiac muscle hypertrophy (GO:0003300)3.65698053
62regulation of heart rate by cardiac conduction (GO:0086091)3.64109446
63regulation of coenzyme metabolic process (GO:0051196)3.63371906
64regulation of cofactor metabolic process (GO:0051193)3.63371906
65regulation of acyl-CoA biosynthetic process (GO:0050812)3.60813528
66cardiac muscle cell action potential involved in contraction (GO:0086002)3.59425366
67actomyosin structure organization (GO:0031032)3.58979686
68muscle tissue morphogenesis (GO:0060415)3.58275133
69regulation of heart rate (GO:0002027)3.57733159
70protein complex biogenesis (GO:0070271)3.54389956
71protein-chromophore linkage (GO:0018298)3.53631439
72venous blood vessel morphogenesis (GO:0048845)3.53387311
73positive regulation of heart rate (GO:0010460)3.52538690
74cardiac conduction (GO:0061337)3.50927606
75mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.48917332
76mitochondrial respiratory chain complex I assembly (GO:0032981)3.48917332
77NADH dehydrogenase complex assembly (GO:0010257)3.48917332
78striated muscle hypertrophy (GO:0014897)3.43142452
79actin-mediated cell contraction (GO:0070252)3.42031712
80fucose catabolic process (GO:0019317)3.41324561
81L-fucose metabolic process (GO:0042354)3.41324561
82L-fucose catabolic process (GO:0042355)3.41324561
83positive regulation of potassium ion transmembrane transport (GO:1901381)3.41188045
84regulation of rhodopsin mediated signaling pathway (GO:0022400)3.40245526
85mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.34682415
86negative regulation of calcium ion transmembrane transport (GO:1903170)3.33612084
87negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.33612084
88relaxation of cardiac muscle (GO:0055119)3.32269145
89striatum development (GO:0021756)3.32096893
90carnitine shuttle (GO:0006853)3.31703203
91response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.28649699
92indolalkylamine metabolic process (GO:0006586)3.27265364
93cytidine metabolic process (GO:0046087)3.27142792
94cytidine catabolic process (GO:0006216)3.27142792
95cytidine deamination (GO:0009972)3.27142792
96protein neddylation (GO:0045116)3.24823654
97membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.23825798
98negative regulation of potassium ion transport (GO:0043267)3.22182939
99regulation of action potential (GO:0098900)3.18401317
100photoreceptor cell maintenance (GO:0045494)3.17983073
101regulation of heart contraction (GO:0008016)3.17594140
102creatine metabolic process (GO:0006600)3.17525859
103regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.17021209
104muscle hypertrophy (GO:0014896)3.16594386
105positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.16317516
106neuronal action potential (GO:0019228)3.15687016
107tryptophan catabolic process (GO:0006569)3.15488477
108indole-containing compound catabolic process (GO:0042436)3.15488477
109indolalkylamine catabolic process (GO:0046218)3.15488477
110heart contraction (GO:0060047)3.13203499
111heart process (GO:0003015)3.13203499
112mitochondrial respiratory chain complex assembly (GO:0033108)3.13158060
113response to inactivity (GO:0014854)3.12184251
114protein polyglutamylation (GO:0018095)3.11646257
115regulation of voltage-gated calcium channel activity (GO:1901385)3.10421847
116regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.08976745
117parturition (GO:0007567)3.08826215
118ATP synthesis coupled proton transport (GO:0015986)3.07813383
119energy coupled proton transport, down electrochemical gradient (GO:0015985)3.07813383
120regulation of calcium ion transmembrane transport (GO:1903169)3.07634584
121regulation of calcium ion transmembrane transporter activity (GO:1901019)3.07634584
122axoneme assembly (GO:0035082)3.04829017
123ubiquinone biosynthetic process (GO:0006744)3.04411282
124quinone biosynthetic process (GO:1901663)3.04411282
125epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.04266907
126negative regulation of mast cell activation (GO:0033004)3.03976742
127sodium ion export (GO:0071436)3.02443038
128positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.01935081
129fatty acid transmembrane transport (GO:1902001)3.00398727
130primary amino compound metabolic process (GO:1901160)2.99049910
131epithelial cilium movement (GO:0003351)2.97695775
132kidney morphogenesis (GO:0060993)2.97003024
133platelet dense granule organization (GO:0060155)2.94741671
134piRNA metabolic process (GO:0034587)2.94741429
135establishment of protein localization to mitochondrial membrane (GO:0090151)2.94564981
136somite development (GO:0061053)2.94465820
137serotonin metabolic process (GO:0042428)2.93826105
138cornea development in camera-type eye (GO:0061303)2.93443581
139indole-containing compound metabolic process (GO:0042430)2.88072418
140tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.85296925
141RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.85296925
142cell proliferation in forebrain (GO:0021846)2.83808526
143kynurenine metabolic process (GO:0070189)2.82807562
144sulfation (GO:0051923)2.82654236
145mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.80705673
146regulation of mesoderm development (GO:2000380)2.77711814
147protein localization to cilium (GO:0061512)2.76987581
148pyrimidine ribonucleoside catabolic process (GO:0046133)2.74844198
149detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.74630415
150synaptic transmission, cholinergic (GO:0007271)2.72774195
151negative regulation of telomere maintenance (GO:0032205)2.72201521
152transmission of nerve impulse (GO:0019226)2.70429612
153nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.70253190
154positive regulation of cAMP-mediated signaling (GO:0043950)2.69525404
155exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.65130435
156regulation of meiosis I (GO:0060631)2.63586892
157preassembly of GPI anchor in ER membrane (GO:0016254)2.63288075
158tryptophan metabolic process (GO:0006568)2.62291980
159gamma-aminobutyric acid transport (GO:0015812)2.61030377
160negative regulation of response to food (GO:0032096)2.60883403
161negative regulation of appetite (GO:0032099)2.60883403
162glycerophospholipid catabolic process (GO:0046475)2.58812388
163pharyngeal system development (GO:0060037)2.53865546
164positive regulation of meiosis (GO:0045836)2.53083822
165negative regulation of synaptic transmission, GABAergic (GO:0032229)2.51799540
166RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.46604610
167regulation of cilium movement (GO:0003352)2.46173236
168DNA methylation involved in gamete generation (GO:0043046)2.45826947
169positive regulation of fatty acid transport (GO:2000193)2.43915731
170cellular ketone body metabolic process (GO:0046950)2.42657634
171action potential (GO:0001508)2.40489423
172negative regulation of transcription regulatory region DNA binding (GO:2000678)2.38933803
173electron transport chain (GO:0022900)2.38379748
174endoderm formation (GO:0001706)2.37206516
175adenosine metabolic process (GO:0046085)2.36964813
176adaptation of signaling pathway (GO:0023058)2.36748042
177behavioral response to ethanol (GO:0048149)2.35463204
178positive regulation of meiotic cell cycle (GO:0051446)2.34381760
179respiratory chain complex IV assembly (GO:0008535)2.33485107
180mannosylation (GO:0097502)2.32307369
181respiratory electron transport chain (GO:0022904)2.31809848
182cellular response to ATP (GO:0071318)2.30220554
183otic vesicle formation (GO:0030916)2.30084529
184dentate gyrus development (GO:0021542)2.28351538
185positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.27489483
186positive regulation of defense response to virus by host (GO:0002230)2.27332046
187GPI anchor metabolic process (GO:0006505)2.27273704
188phosphatidylinositol acyl-chain remodeling (GO:0036149)2.27177995
189nonmotile primary cilium assembly (GO:0035058)2.27112238

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse4.24674578
2GBX2_23144817_ChIP-Seq_PC3_Human3.87617176
3EZH2_22144423_ChIP-Seq_EOC_Human3.24068463
4ZNF274_21170338_ChIP-Seq_K562_Hela3.12721065
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.98659248
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.94738974
7RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.81197091
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.47060559
9EP300_21415370_ChIP-Seq_HL-1_Mouse2.38392720
10FLI1_27457419_Chip-Seq_LIVER_Mouse2.28434994
11CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.26195889
12SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.12856709
13CDX2_19796622_ChIP-Seq_MESCs_Mouse2.12804076
14EWS_26573619_Chip-Seq_HEK293_Human2.09594308
15EZH2_27294783_Chip-Seq_ESCs_Mouse2.04080934
16JARID2_20064375_ChIP-Seq_MESCs_Mouse2.02454078
17EZH2_27304074_Chip-Seq_ESCs_Mouse1.97916194
18DROSHA_22980978_ChIP-Seq_HELA_Human1.97807591
19SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.96945267
20PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.94338720
21AR_21572438_ChIP-Seq_LNCaP_Human1.86243907
22HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.84759399
23* TBX20_22328084_ChIP-Seq_HEART_Mouse1.84393144
24* TBX20_22080862_ChIP-Seq_HEART_Mouse1.84393144
25JARID2_20075857_ChIP-Seq_MESCs_Mouse1.81555886
26SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.77817515
27P53_22127205_ChIP-Seq_FIBROBLAST_Human1.72611885
28EZH2_18974828_ChIP-Seq_MESCs_Mouse1.72065362
29RNF2_18974828_ChIP-Seq_MESCs_Mouse1.72065362
30CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.71040898
31SUZ12_27294783_Chip-Seq_ESCs_Mouse1.69524721
32MTF2_20144788_ChIP-Seq_MESCs_Mouse1.69516248
33SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.66615382
34SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.66438922
35ESR1_20079471_ChIP-ChIP_T-47D_Human1.65078204
36ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.63068844
37EED_16625203_ChIP-ChIP_MESCs_Mouse1.62679468
38* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.59596081
39* SMAD4_21799915_ChIP-Seq_A2780_Human1.59092565
40GABP_17652178_ChIP-ChIP_JURKAT_Human1.58705489
41EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.58002680
42PIAS1_25552417_ChIP-Seq_VCAP_Human1.54568849
43MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.50828087
44TP53_22573176_ChIP-Seq_HFKS_Human1.50150895
45RNF2_27304074_Chip-Seq_ESCs_Mouse1.49819270
46* SMAD3_21741376_ChIP-Seq_HESCs_Human1.49465083
47GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.45559883
48AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.45215969
49TAF15_26573619_Chip-Seq_HEK293_Human1.45077603
50* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.43374011
51PCGF2_27294783_Chip-Seq_NPCs_Mouse1.43030507
52PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.41603571
53MYC_18940864_ChIP-ChIP_HL60_Human1.39762580
54TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.39760330
55POU3F2_20337985_ChIP-ChIP_501MEL_Human1.38858895
56NOTCH1_21737748_ChIP-Seq_TLL_Human1.37447286
57MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.36966300
58IRF1_19129219_ChIP-ChIP_H3396_Human1.35946378
59RNF2_27304074_Chip-Seq_NSC_Mouse1.35705377
60RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.35255353
61IGF1R_20145208_ChIP-Seq_DFB_Human1.35028955
62E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.34285807
63CBX2_27304074_Chip-Seq_ESCs_Mouse1.33081011
64* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.32738534
65FOXA1_27270436_Chip-Seq_PROSTATE_Human1.31377945
66FOXA1_25329375_ChIP-Seq_VCAP_Human1.31377945
67NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.30672998
68GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.30329710
69MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.29478778
70PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.28817552
71EST1_17652178_ChIP-ChIP_JURKAT_Human1.27090530
72NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.26766865
73* NANOG_19829295_ChIP-Seq_ESCs_Human1.26671953
74* SOX2_19829295_ChIP-Seq_ESCs_Human1.26671953
75KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.26415176
76SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.26191717
77MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.25254983
78CTBP2_25329375_ChIP-Seq_LNCAP_Human1.25018702
79REST_21632747_ChIP-Seq_MESCs_Mouse1.24684089
80NCOR_22424771_ChIP-Seq_293T_Human1.24140486
81SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.23987248
82TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.22612057
83VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.21501535
84ER_23166858_ChIP-Seq_MCF-7_Human1.20432275
85PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.20064201
86CTCF_27219007_Chip-Seq_Bcells_Human1.19463229
87KLF5_20875108_ChIP-Seq_MESCs_Mouse1.18634238
88SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17186009
89BCAT_22108803_ChIP-Seq_LS180_Human1.15303183
90TCF4_22108803_ChIP-Seq_LS180_Human1.15216659
91EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.15080509
92RUNX2_22187159_ChIP-Seq_PCA_Human1.14847137
93RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.14522975
94P300_19829295_ChIP-Seq_ESCs_Human1.13135675
95HTT_18923047_ChIP-ChIP_STHdh_Human1.13056400
96P53_22387025_ChIP-Seq_ESCs_Mouse1.12993387
97NANOG_18555785_Chip-Seq_ESCs_Mouse1.12533167
98PRDM14_20953172_ChIP-Seq_ESCs_Human1.12501186
99TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.12370335
100FOXA1_21572438_ChIP-Seq_LNCaP_Human1.12260717
101AUTS2_25519132_ChIP-Seq_293T-REX_Human1.10639400
102CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.10292370
103POU5F1_16153702_ChIP-ChIP_HESCs_Human1.09596021
104* SMAD4_21741376_ChIP-Seq_EPCs_Human1.09361747
105* FLI1_21867929_ChIP-Seq_TH2_Mouse1.08869986
106* SMAD4_21741376_ChIP-Seq_HESCs_Human1.08633169
107SMAD_19615063_ChIP-ChIP_OVARY_Human1.08438053
108CRX_20693478_ChIP-Seq_RETINA_Mouse1.08189034
109TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08008237
110POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.08008237
111* SMAD3_21741376_ChIP-Seq_EPCs_Human1.07710020
112SUZ12_27294783_Chip-Seq_NPCs_Mouse1.07630669
113VDR_22108803_ChIP-Seq_LS180_Human1.07504922
114OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06536971
115TCF4_23295773_ChIP-Seq_U87_Human1.06534838
116* AR_20517297_ChIP-Seq_VCAP_Human1.05727041
117GATA3_21878914_ChIP-Seq_MCF-7_Human1.05430859
118ETV2_25802403_ChIP-Seq_MESCs_Mouse1.05246562
119TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.04767339
120PCGF2_27294783_Chip-Seq_ESCs_Mouse1.04093813
121TBL1_22424771_ChIP-Seq_293T_Human1.04048380
122STAT3_18555785_Chip-Seq_ESCs_Mouse1.03251249
123TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.02532799
124BMI1_23680149_ChIP-Seq_NPCS_Mouse1.02314754
125ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.02226893
126BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.01623112
127CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01455031
128TAL1_26923725_Chip-Seq_HPCs_Mouse1.01420109
129* AR_25329375_ChIP-Seq_VCAP_Human1.01018552
130NFE2_27457419_Chip-Seq_LIVER_Mouse1.00436578
131CBP_21632823_ChIP-Seq_H3396_Human0.98144517
132STAT3_23295773_ChIP-Seq_U87_Human0.97962493
133REST_18959480_ChIP-ChIP_MESCs_Mouse0.97379785
134FUS_26573619_Chip-Seq_HEK293_Human0.94187331
135EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.94156145
136RING1B_27294783_Chip-Seq_ESCs_Mouse0.93558664
137SOX2_21211035_ChIP-Seq_LN229_Gbm0.92787441
138GATA4_21415370_ChIP-Seq_HL-1_Mouse0.92702555
139* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.92694865
140AR_19668381_ChIP-Seq_PC3_Human0.92209185
141NR3C1_23031785_ChIP-Seq_PC12_Mouse0.91959301
142NR3C1_21868756_ChIP-Seq_MCF10A_Human0.90956074
143EZH2_27294783_Chip-Seq_NPCs_Mouse0.89662908
144CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.88980473
145BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.88370488
146* ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.87281319
147CBP_20019798_ChIP-Seq_JUKART_Human0.87187642
148IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.87187642
149CTNNB1_20460455_ChIP-Seq_HCT116_Human0.86660915
150E2F1_18555785_Chip-Seq_ESCs_Mouse0.84431799
151MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.84289121
152TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.84117747
153* PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.84091483
154TOP2B_26459242_ChIP-Seq_MCF-7_Human0.83384736
155* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82796756

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue5.23172096
2MP0002837_dystrophic_cardiac_calcinosis4.95088015
3MP0004084_abnormal_cardiac_muscle4.72715137
4MP0004215_abnormal_myocardial_fiber4.63295561
5MP0005551_abnormal_eye_electrophysiolog4.27267972
6MP0000751_myopathy4.04042410
7MP0004036_abnormal_muscle_relaxation3.89352882
8MP0008877_abnormal_DNA_methylation3.24792568
9MP0000749_muscle_degeneration3.20965725
10MP0008775_abnormal_heart_ventricle3.02321470
11MP0005330_cardiomyopathy3.01392038
12MP0002090_abnormal_vision2.88237815
13MP0006072_abnormal_retinal_apoptosis2.80729754
14MP0002102_abnormal_ear_morphology2.71328334
15MP0003137_abnormal_impulse_conducting2.56785223
16MP0005646_abnormal_pituitary_gland2.55153421
17MP0002972_abnormal_cardiac_muscle2.47670785
18MP0010368_abnormal_lymphatic_system2.43720032
19MP0005620_abnormal_muscle_contractility2.38701512
20MP0005253_abnormal_eye_physiology2.38336114
21MP0003950_abnormal_plasma_membrane2.36642366
22MP0003195_calcinosis2.34393988
23MP0004233_abnormal_muscle_weight2.20144897
24MP0004130_abnormal_muscle_cell2.17852129
25MP0001984_abnormal_olfaction2.17015020
26MP0004087_abnormal_muscle_fiber2.17014823
27MP0003787_abnormal_imprinting2.10771951
28MP0004885_abnormal_endolymph2.05488772
29MP0002736_abnormal_nociception_after2.02610137
30MP0004145_abnormal_muscle_electrophysio2.02576817
31MP0002160_abnormal_reproductive_system2.01222299
32MP0006292_abnormal_olfactory_placode1.99644219
33MP0003011_delayed_dark_adaptation1.99275813
34MP0005670_abnormal_white_adipose1.96263733
35MP0004484_altered_response_of1.95847378
36MP0005645_abnormal_hypothalamus_physiol1.91552062
37MP0004085_abnormal_heartbeat1.90715671
38MP0005385_cardiovascular_system_phenoty1.89777420
39MP0001544_abnormal_cardiovascular_syste1.89777420
40MP0002332_abnormal_exercise_endurance1.89184721
41MP0002138_abnormal_hepatobiliary_system1.86535767
42MP0000750_abnormal_muscle_regeneration1.84287896
43MP0002106_abnormal_muscle_physiology1.81671927
44MP0009745_abnormal_behavioral_response1.80392970
45MP0008872_abnormal_physiological_respon1.79752700
46MP0002876_abnormal_thyroid_physiology1.79510373
47MP0002163_abnormal_gland_morphology1.77151521
48MP0005389_reproductive_system_phenotype1.75605829
49MP0010630_abnormal_cardiac_muscle1.75216939
50MP0001986_abnormal_taste_sensitivity1.69879781
51MP0003283_abnormal_digestive_organ1.67980432
52MP0006276_abnormal_autonomic_nervous1.66715026
53MP0000631_abnormal_neuroendocrine_gland1.55306117
54MP0002638_abnormal_pupillary_reflex1.55291861
55MP0002127_abnormal_cardiovascular_syste1.54904609
56MP0002269_muscular_atrophy1.53432507
57MP0005195_abnormal_posterior_eye1.50601142
58MP0001502_abnormal_circadian_rhythm1.50030476
59MP0000759_abnormal_skeletal_muscle1.49228525
60MP0004510_myositis1.48428584
61MP0004142_abnormal_muscle_tone1.47747805
62MP0004133_heterotaxia1.46968456
63MP0005369_muscle_phenotype1.46348828
64MP0001188_hyperpigmentation1.46218235
65MP0002234_abnormal_pharynx_morphology1.43543998
66MP0002938_white_spotting1.43415546
67MP0000372_irregular_coat_pigmentation1.41704249
68MP0005084_abnormal_gallbladder_morpholo1.40377970
69MP0005379_endocrine/exocrine_gland_phen1.37823312
70MP0002653_abnormal_ependyma_morphology1.35096487
71MP0001485_abnormal_pinna_reflex1.33154140
72MP0006036_abnormal_mitochondrial_physio1.32561167
73MP0008875_abnormal_xenobiotic_pharmacok1.31051747
74MP0006138_congestive_heart_failure1.30984782
75MP0005671_abnormal_response_to1.27796691
76MP0005409_darkened_coat_color1.26562654
77MP0003828_pulmonary_edema1.26456009
78MP0004147_increased_porphyrin_level1.25993271
79MP0005666_abnormal_adipose_tissue1.25637457
80MP0002733_abnormal_thermal_nociception1.23411255
81MP0002909_abnormal_adrenal_gland1.22610063
82MP0003880_abnormal_central_pattern1.22595251
83MP0003221_abnormal_cardiomyocyte_apopto1.22233622
84MP0002735_abnormal_chemical_nociception1.22129848
85MP0001970_abnormal_pain_threshold1.18623940
86MP0002734_abnormal_mechanical_nocicepti1.17869534
87MP0003122_maternal_imprinting1.16394396
88MP0003121_genomic_imprinting1.15982357
89MP0001501_abnormal_sleep_pattern1.15303531
90MP0002822_catalepsy1.11104169
91MP0001919_abnormal_reproductive_system1.10914798
92MP0002064_seizures1.10368140
93MP0002572_abnormal_emotion/affect_behav1.09368800
94MP0005595_abnormal_vascular_smooth1.08071745
95MP0002557_abnormal_social/conspecific_i1.06768542
96MP0001879_abnormal_lymphatic_vessel1.05946504
97MP0001905_abnormal_dopamine_level1.05151578
98MP0002928_abnormal_bile_duct1.03644452
99MP0000049_abnormal_middle_ear1.02363172
100MP0010386_abnormal_urinary_bladder1.00174576
101MP0000569_abnormal_digit_pigmentation0.99496758
102MP0005165_increased_susceptibility_to0.99372584
103MP0002229_neurodegeneration0.98894522
104MP0002693_abnormal_pancreas_physiology0.97894115
105MP0003635_abnormal_synaptic_transmissio0.97646996
106MP0005075_abnormal_melanosome_morpholog0.97354493
107MP0006035_abnormal_mitochondrial_morpho0.96824779
108MP0000427_abnormal_hair_cycle0.96425991
109MP0000747_muscle_weakness0.96279763
110MP0000230_abnormal_systemic_arterial0.96035244
111MP0004043_abnormal_pH_regulation0.94622868
112MP0001324_abnormal_eye_pigmentation0.91854016
113MP0004782_abnormal_surfactant_physiolog0.91312433
114MP0002277_abnormal_respiratory_mucosa0.89023799
115MP0002063_abnormal_learning/memory/cond0.88730518
116MP0005410_abnormal_fertilization0.88730226
117MP0003119_abnormal_digestive_system0.88583414
118MP0000026_abnormal_inner_ear0.87677376
119MP0002184_abnormal_innervation0.86916884
120MP0005248_abnormal_Harderian_gland0.86054629
121MP0003136_yellow_coat_color0.85111713
122MP0001963_abnormal_hearing_physiology0.84133431
123MP0004742_abnormal_vestibular_system0.83953362
124MP0008995_early_reproductive_senescence0.83474990
125MP0000613_abnormal_salivary_gland0.82016410
126MP0005391_vision/eye_phenotype0.80786024
127MP0001440_abnormal_grooming_behavior0.79844361
128MP0002752_abnormal_somatic_nervous0.79648668
129MP0005266_abnormal_metabolism0.77183158
130MP0004185_abnormal_adipocyte_glucose0.76352043
131MP0003252_abnormal_bile_duct0.74863370
132MP0002067_abnormal_sensory_capabilities0.74201284
133MP0001944_abnormal_pancreas_morphology0.72771915
134MP0008004_abnormal_stomach_pH0.72434613
135MP0001486_abnormal_startle_reflex0.72422728
136MP0005332_abnormal_amino_acid0.71643451
137MP0002751_abnormal_autonomic_nervous0.71323698
138MP0002272_abnormal_nervous_system0.70929022
139MP0000383_abnormal_hair_follicle0.70696373
140MP0001873_stomach_inflammation0.70460298
141MP0005636_abnormal_mineral_homeostasis0.67724487
142MP0000266_abnormal_heart_morphology0.67653667
143MP0009697_abnormal_copulation0.67609836
144MP0003868_abnormal_feces_composition0.67375284
145MP0000343_altered_response_to0.65212550
146MP0003879_abnormal_hair_cell0.64640766
147MP0008569_lethality_at_weaning0.63543586
148MP0005375_adipose_tissue_phenotype0.62428116
149MP0002108_abnormal_muscle_morphology0.61693776
150MP0004924_abnormal_behavior0.58875715
151MP0005386_behavior/neurological_phenoty0.58875715
152MP0002078_abnormal_glucose_homeostasis0.53465305
153MP0005535_abnormal_body_temperature0.52713473
154MP0001529_abnormal_vocalization0.51417274
155MP0005423_abnormal_somatic_nervous0.50136675
156MP0001968_abnormal_touch/_nociception0.49495284
157MP0001346_abnormal_lacrimal_gland0.47962348
158MP0009046_muscle_twitch0.47508964
159MP0005365_abnormal_bile_salt0.47259352
160MP0005334_abnormal_fat_pad0.44421414
161MP0005319_abnormal_enzyme/_coenzyme0.42964113
162MP0002882_abnormal_neuron_morphology0.42197926
163MP0003279_aneurysm0.41425763
164MP0008789_abnormal_olfactory_epithelium0.41330695
165MP0002971_abnormal_brown_adipose0.41189504
166MP0003567_abnormal_fetal_cardiomyocyte0.40187625
167MP0008260_abnormal_autophagy0.36754475

Predicted human phenotypes

RankGene SetZ-score
1Central scotoma (HP:0000603)6.38755522
2Atrial fibrillation (HP:0005110)5.98114242
3Sudden death (HP:0001699)5.93776080
4Primary atrial arrhythmia (HP:0001692)5.53474028
5Supraventricular tachycardia (HP:0004755)5.34092622
6Ventricular tachycardia (HP:0004756)5.18995220
7Supraventricular arrhythmia (HP:0005115)5.17960556
8Prolonged QT interval (HP:0001657)5.10229461
9Abnormality of macular pigmentation (HP:0008002)5.04343552
10Syncope (HP:0001279)4.85980442
11Calf muscle hypertrophy (HP:0008981)4.85123043
12Severe visual impairment (HP:0001141)4.77767528
13Exercise-induced myalgia (HP:0003738)4.53325298
14Muscle hypertrophy of the lower extremities (HP:0008968)4.47524457
15Scotoma (HP:0000575)4.31277083
16Exercise-induced muscle cramps (HP:0003710)4.18610839
17Lipoatrophy (HP:0100578)4.18605616
18Decreased central vision (HP:0007663)4.16950448
19Pancreatic cysts (HP:0001737)4.09091726
20Abnormal rod and cone electroretinograms (HP:0008323)4.06598914
21Palpitations (HP:0001962)4.02274514
22Abnormality of the calf musculature (HP:0001430)3.95902988
23Myoglobinuria (HP:0002913)3.92400773
24Pancreatic fibrosis (HP:0100732)3.74370704
25True hermaphroditism (HP:0010459)3.68683747
26Ventricular fibrillation (HP:0001663)3.63698173
27Dilated cardiomyopathy (HP:0001644)3.58202632
28Abnormal EKG (HP:0003115)3.54262938
29Right ventricular cardiomyopathy (HP:0011663)3.53672311
30Dyschromatopsia (HP:0007641)3.48606201
31Molar tooth sign on MRI (HP:0002419)3.33764881
32Abnormality of midbrain morphology (HP:0002418)3.33764881
33Nephronophthisis (HP:0000090)3.28368947
34Muscle fiber splitting (HP:0003555)3.23480758
35Ventricular arrhythmia (HP:0004308)3.12572201
36Bony spicule pigmentary retinopathy (HP:0007737)3.04337703
37Abnormality of the left ventricular outflow tract (HP:0011103)3.01071050
38Subaortic stenosis (HP:0001682)3.01071050
39Bundle branch block (HP:0011710)2.95557073
40Increased corneal curvature (HP:0100692)2.93830396
41Keratoconus (HP:0000563)2.93830396
42Abnormality of the renal cortex (HP:0011035)2.91690331
43Left ventricular hypertrophy (HP:0001712)2.89730310
44Medial flaring of the eyebrow (HP:0010747)2.87163209
45EMG: myopathic abnormalities (HP:0003458)2.85725789
46Optic disc pallor (HP:0000543)2.85253044
47Hepatic necrosis (HP:0002605)2.82174193
48Heart block (HP:0012722)2.81211279
49Abnormality of the renal medulla (HP:0100957)2.80846631
50Febrile seizures (HP:0002373)2.77660028
51Rhabdomyolysis (HP:0003201)2.76415143
52Congenital, generalized hypertrichosis (HP:0004540)2.71701808
53Absent rod-and cone-mediated responses on ERG (HP:0007688)2.69224515
54Septo-optic dysplasia (HP:0100842)2.64394907
55Atrioventricular block (HP:0001678)2.63358111
56Abnormal atrioventricular conduction (HP:0005150)2.61863941
57Aplasia/Hypoplasia of the fovea (HP:0008060)2.60990871
58Hypoplasia of the fovea (HP:0007750)2.60990871
59Increased muscle lipid content (HP:0009058)2.60325194
60Abnormal mitochondria in muscle tissue (HP:0008316)2.59557598
61Hepatocellular necrosis (HP:0001404)2.58673273
62Attenuation of retinal blood vessels (HP:0007843)2.55435430
63Abnormality of alanine metabolism (HP:0010916)2.54432108
64Hyperalaninemia (HP:0003348)2.54432108
65Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.54432108
66Hyporeflexia of lower limbs (HP:0002600)2.52677881
67Acute necrotizing encephalopathy (HP:0006965)2.51539774
68Pendular nystagmus (HP:0012043)2.47430580
69Increased intramyocellular lipid droplets (HP:0012240)2.46360031
70Epileptic encephalopathy (HP:0200134)2.45072567
71Asymmetric septal hypertrophy (HP:0001670)2.44858108
72Cystic liver disease (HP:0006706)2.44139119
73Type II lissencephaly (HP:0007260)2.39468477
74Mitochondrial inheritance (HP:0001427)2.39163063
75Methylmalonic acidemia (HP:0002912)2.37726994
763-Methylglutaconic aciduria (HP:0003535)2.35205903
77Decreased electroretinogram (ERG) amplitude (HP:0000654)2.33046759
78Abnormal drinking behavior (HP:0030082)2.32154760
79Polydipsia (HP:0001959)2.32154760
80Male pseudohermaphroditism (HP:0000037)2.22729935
81Gait imbalance (HP:0002141)2.21784442
82Tubular atrophy (HP:0000092)2.21748262
83Aplasia/Hypoplasia of the spleen (HP:0010451)2.21740408
84Congenital sensorineural hearing impairment (HP:0008527)2.20863653
85Asplenia (HP:0001746)2.19624460
86Hypothermia (HP:0002045)2.19485777
87Progressive macrocephaly (HP:0004481)2.16097041
88Increased CSF lactate (HP:0002490)2.15573201
89Congenital primary aphakia (HP:0007707)2.14980857
90Cerebral edema (HP:0002181)2.14387978
91Hypoglycemic coma (HP:0001325)2.14060657
92Abnormality of the fovea (HP:0000493)2.14021657
93Sclerocornea (HP:0000647)2.13868646
94Absent/shortened dynein arms (HP:0200106)2.13774279
95Dynein arm defect of respiratory motile cilia (HP:0012255)2.13774279
96Maternal diabetes (HP:0009800)2.13443388
97Dysmetric saccades (HP:0000641)2.13126872
98Acute encephalopathy (HP:0006846)2.12608706
99Dicarboxylic aciduria (HP:0003215)2.11780251
100Abnormality of dicarboxylic acid metabolism (HP:0010995)2.11780251
101Ketoacidosis (HP:0001993)2.11776578
102Abnormality of fatty-acid metabolism (HP:0004359)2.10081497
103Renal Fanconi syndrome (HP:0001994)2.08659701
104Furrowed tongue (HP:0000221)2.08097944
105Lipid accumulation in hepatocytes (HP:0006561)2.03332797
106Pigmentary retinal degeneration (HP:0001146)2.02507751
107Progressive cerebellar ataxia (HP:0002073)2.02495674
108Testicular atrophy (HP:0000029)2.02357756
109Decreased circulating renin level (HP:0003351)2.01052343
110Thyroiditis (HP:0100646)2.00413641
111Nephrogenic diabetes insipidus (HP:0009806)2.00060183
112Congenital stationary night blindness (HP:0007642)11.2876930
113Methylmalonic aciduria (HP:0012120)1.99216226
114Genital tract atresia (HP:0001827)1.99201541
115Increased connective tissue (HP:0009025)1.98705348
116Myotonia (HP:0002486)1.96542804
117Lactic acidosis (HP:0003128)1.96497603
118Exercise intolerance (HP:0003546)1.96213085
119Large for gestational age (HP:0001520)1.95063079
120Aplasia/Hypoplasia of the tongue (HP:0010295)1.93967960
121Aplasia/hypoplasia of the uterus (HP:0008684)1.93262183
122Abnormal respiratory epithelium morphology (HP:0012253)1.93253283
123Abnormal respiratory motile cilium morphology (HP:0005938)1.93253283
124Congenital hepatic fibrosis (HP:0002612)1.93154031
125Polyuria (HP:0000103)1.92149372
126Vaginal atresia (HP:0000148)1.92046478
127Aplasia/Hypoplasia of the tibia (HP:0005772)1.91395425
128Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.90507332
129Type 2 muscle fiber atrophy (HP:0003554)1.89719001
130Broad-based gait (HP:0002136)1.89249116
131Palmoplantar keratoderma (HP:0000982)1.87460686
132Gaze-evoked nystagmus (HP:0000640)1.85986347
133Abnormality of urine glucose concentration (HP:0011016)1.85760050
134Glycosuria (HP:0003076)1.85760050
135Absent phalangeal crease (HP:0006109)1.85089472
136Hypoplasia of the uterus (HP:0000013)1.84490483
137Muscle stiffness (HP:0003552)1.84286361
138Hemiparesis (HP:0001269)1.84057069
139Absence seizures (HP:0002121)1.83529103
140Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.83192956
141Albinism (HP:0001022)1.82413392
142Abnormality of renal resorption (HP:0011038)1.82256707
143IgG deficiency (HP:0004315)1.80683255
144Ragged-red muscle fibers (HP:0003200)1.80153668
145Agitation (HP:0000713)1.79703064
146Anencephaly (HP:0002323)1.79473499
147Symphalangism affecting the phalanges of the hand (HP:0009773)1.79209334
148Hypoproteinemia (HP:0003075)1.78968969
149Inability to walk (HP:0002540)1.78843094
150Hyperventilation (HP:0002883)1.78295018
151Photophobia (HP:0000613)1.77904791
152Short tibia (HP:0005736)1.75078531
153Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.74387192
154Chorioretinal atrophy (HP:0000533)1.73495669
155Abolished electroretinogram (ERG) (HP:0000550)1.72564801
156Renal cortical cysts (HP:0000803)1.72400391
157Cone-rod dystrophy (HP:0000548)1.72204141
158Increased hepatocellular lipid droplets (HP:0006565)1.71883452
159Abnormality of the labia minora (HP:0012880)1.71868194
160Optic nerve hypoplasia (HP:0000609)1.71455104
161Postaxial foot polydactyly (HP:0001830)1.71018897
162Abnormality of the renal collecting system (HP:0004742)1.70324432
163Ketosis (HP:0001946)1.69850379
164Absent septum pellucidum (HP:0001331)1.68176110
165Prenatal maternal abnormality (HP:0002686)1.67960721
166Generalized aminoaciduria (HP:0002909)1.65610562

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.07381038
2PHKG24.05341260
3PHKG14.05341260
4TTN3.50511701
5ADRBK23.26818119
6PINK13.26229546
7MAP4K22.93341419
8OBSCN2.88391369
9PBK2.82595539
10LMTK22.80664849
11BMPR1B2.75418955
12MUSK2.68254092
13NEK12.55729517
14MYLK2.53571907
15BCKDK2.50575081
16STK38L2.47050657
17NUAK12.38388510
18WNK32.37007491
19INSRR2.31251101
20TXK2.29211050
21STK382.26739036
22TAOK32.05838645
23CASK1.97424492
24PRPF4B1.86544783
25CAMK2D1.85922087
26GRK71.84735638
27CLK11.76886774
28PDK31.74560624
29PDK41.74560624
30TNIK1.71079497
31TIE11.67470764
32OXSR11.67017739
33ACVR1B1.62521649
34DMPK1.58468552
35MAPK131.58268773
36PKN21.55839099
37MST41.55755716
38STK391.54850808
39TAOK21.53758268
40PIK3CA1.51965596
41MAP3K71.39124419
42PRKAA11.33012732
43CAMK11.28044930
44EPHA31.21819913
45NME21.19777120
46VRK11.14564947
47NME11.14439725
48CAMK41.14310383
49DYRK21.12142584
50ZAK1.09954458
51PRKAA21.09370316
52PLK21.08840838
53PRKD21.07837962
54EIF2AK31.06769073
55GRK11.06082465
56CDK31.05447515
57PKN11.05003780
58VRK21.02688866
59DAPK21.02623328
60TRIM281.01880406
61STK161.00584057
62FES0.99279145
63PRKCG0.94930245
64ADRBK10.94538601
65MAPK120.94395560
66FGFR20.94336822
67PDK20.94006568
68CSNK1G10.93659141
69PRKD10.90970460
70STK240.88583928
71MAP2K60.88497542
72PRKG20.87863773
73NTRK30.86775285
74CAMK2A0.86065508
75IRAK10.85960858
76MAP2K70.85607537
77CSNK1G20.81739816
78RIPK10.81142219
79PAK30.78899383
80IRAK20.78433877
81IRAK30.76164531
82MAPKAPK30.73703616
83CSNK1G30.73414986
84FLT30.71868056
85PRKCQ0.70937504
86KIT0.70250505
87PRKCE0.69614367
88ITK0.69583732
89YES10.69135972
90IKBKB0.68901709
91PRKACA0.66709664
92CDK190.66354590
93TAF10.63772162
94PRKG10.63415492
95PLK30.62444470
96ROCK10.61702493
97EPHA40.61039227
98PNCK0.61021340
99CDC42BPA0.60624648
100FER0.60586190
101NEK90.60059009
102TGFBR10.59073530
103NLK0.58165533
104PAK60.55169169
105GRK50.54846735
106TLK10.54402789
107DYRK1A0.54382642
108CAMK1D0.53712604
109PTK2B0.53363418
110SGK20.52214527
111WNK10.51824137
112MKNK20.50595380
113CSNK1A10.50528883
114PRKACG0.49823685
115NTRK20.49658341
116MAP3K50.49300595
117AKT30.48930263
118HIPK20.48342261
119EIF2AK20.45880399
120STK30.45800668
121PRKACB0.45009841
122CSNK1A1L0.44996004
123MARK10.44654983
124SYK0.43509903
125STK40.41483555
126RPS6KL10.41333166
127RPS6KC10.41333166
128CAMKK20.39716478
129BCR0.39327980
130MAP3K40.38941670
131WNK40.37652095
132SGK4940.37321579
133SGK2230.37321579
134PRKCA0.37252249
135PIK3CG0.37180143
136LIMK10.36166687
137CDK80.35748172
138TEC0.35366474
139AKT20.35358559
140DYRK1B0.34507133
141MAPKAPK50.34328864
142STK110.33257301
143RPS6KA60.33121442
144TNK20.32827154
145CAMK2G0.32414449
146ROCK20.32311663
147SIK20.31438615
148PLK40.31434388
149MAPK70.30822931
150SRPK10.29864309
151KDR0.29477931
152PLK10.27786777
153PRKCZ0.27743382
154RPS6KA30.27487192
155EPHB20.26675954
156TGFBR20.26511859
157SGK10.25116885
158RPS6KA50.24829067
159DAPK30.24744881
160ERBB30.24734058

Predicted pathways (KEGG)

RankGene SetZ-score
1Cardiac muscle contraction_Homo sapiens_hsa042604.16833891
2Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.49109879
3Phototransduction_Homo sapiens_hsa047443.35945136
4Dilated cardiomyopathy_Homo sapiens_hsa054143.33462944
5Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.26381175
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.12910773
72-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.87142277
8Maturity onset diabetes of the young_Homo sapiens_hsa049502.59572063
9Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.53688425
10Protein export_Homo sapiens_hsa030602.41752376
11Oxidative phosphorylation_Homo sapiens_hsa001902.35818181
12Circadian rhythm_Homo sapiens_hsa047102.35090310
13GABAergic synapse_Homo sapiens_hsa047272.27422037
14Fatty acid degradation_Homo sapiens_hsa000712.26375836
15Propanoate metabolism_Homo sapiens_hsa006402.23699096
16Parkinsons disease_Homo sapiens_hsa050122.22381203
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.20329772
18Morphine addiction_Homo sapiens_hsa050322.09400452
19Nicotine addiction_Homo sapiens_hsa050332.08474737
20Carbon metabolism_Homo sapiens_hsa012002.05824869
21Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.77037180
22Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.73540507
23Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.73388210
24Nitrogen metabolism_Homo sapiens_hsa009101.72386452
25Alzheimers disease_Homo sapiens_hsa050101.71497659
26Fructose and mannose metabolism_Homo sapiens_hsa000511.65587560
27Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.59276241
28Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.56566487
29Ether lipid metabolism_Homo sapiens_hsa005651.55206487
30RNA polymerase_Homo sapiens_hsa030201.54882989
31Selenocompound metabolism_Homo sapiens_hsa004501.53453659
32Intestinal immune network for IgA production_Homo sapiens_hsa046721.53348514
33Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.49525150
34Caffeine metabolism_Homo sapiens_hsa002321.48166581
35Homologous recombination_Homo sapiens_hsa034401.47624338
36Circadian entrainment_Homo sapiens_hsa047131.47115836
37Biosynthesis of amino acids_Homo sapiens_hsa012301.46214694
38Fatty acid metabolism_Homo sapiens_hsa012121.44712136
39Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.44413946
40Insulin secretion_Homo sapiens_hsa049111.43734595
41Arginine biosynthesis_Homo sapiens_hsa002201.41160270
42Primary immunodeficiency_Homo sapiens_hsa053401.40292132
43Proteasome_Homo sapiens_hsa030501.35498924
44Olfactory transduction_Homo sapiens_hsa047401.35413394
45RNA degradation_Homo sapiens_hsa030181.34777547
46Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.34483435
47Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.32323691
48Chemical carcinogenesis_Homo sapiens_hsa052041.28199879
49Asthma_Homo sapiens_hsa053101.26277408
50Huntingtons disease_Homo sapiens_hsa050161.22204831
51Renin secretion_Homo sapiens_hsa049241.22039715
52Sulfur metabolism_Homo sapiens_hsa009201.21759980
53Basal transcription factors_Homo sapiens_hsa030221.20864215
54Calcium signaling pathway_Homo sapiens_hsa040201.16622409
55Fatty acid elongation_Homo sapiens_hsa000621.14357965
56cGMP-PKG signaling pathway_Homo sapiens_hsa040221.13962342
57Galactose metabolism_Homo sapiens_hsa000521.13437079
58Ribosome_Homo sapiens_hsa030101.12327966
59Pyruvate metabolism_Homo sapiens_hsa006201.12186057
60Starch and sucrose metabolism_Homo sapiens_hsa005001.08600431
61Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.07383590
62Oxytocin signaling pathway_Homo sapiens_hsa049211.06019550
63Type I diabetes mellitus_Homo sapiens_hsa049401.04249407
64Arachidonic acid metabolism_Homo sapiens_hsa005901.03579368
65Synaptic vesicle cycle_Homo sapiens_hsa047211.03081993
66Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.99602455
67Butanoate metabolism_Homo sapiens_hsa006500.99462534
68Salivary secretion_Homo sapiens_hsa049700.98997455
69Cholinergic synapse_Homo sapiens_hsa047250.97696328
70Fanconi anemia pathway_Homo sapiens_hsa034600.96324407
71Primary bile acid biosynthesis_Homo sapiens_hsa001200.94386855
72Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.90900229
73Pentose and glucuronate interconversions_Homo sapiens_hsa000400.90644643
74Collecting duct acid secretion_Homo sapiens_hsa049660.90641555
75Taste transduction_Homo sapiens_hsa047420.90472607
76Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.90393618
77Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.88125169
78Autoimmune thyroid disease_Homo sapiens_hsa053200.87259419
79One carbon pool by folate_Homo sapiens_hsa006700.85523645
80Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.85306805
81Glutamatergic synapse_Homo sapiens_hsa047240.84315139
82Allograft rejection_Homo sapiens_hsa053300.83746908
83Pentose phosphate pathway_Homo sapiens_hsa000300.82908482
84Vascular smooth muscle contraction_Homo sapiens_hsa042700.82186410
85Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.81832406
86Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.81785742
87Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.80728154
88Aldosterone synthesis and secretion_Homo sapiens_hsa049250.79918013
89Central carbon metabolism in cancer_Homo sapiens_hsa052300.78868590
90Tryptophan metabolism_Homo sapiens_hsa003800.78851200
91Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.75401129
92Lysine degradation_Homo sapiens_hsa003100.72613499
93Serotonergic synapse_Homo sapiens_hsa047260.71623156
94PPAR signaling pathway_Homo sapiens_hsa033200.70253059
95beta-Alanine metabolism_Homo sapiens_hsa004100.67546793
96Peroxisome_Homo sapiens_hsa041460.67288211
97Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.67175173
98Fat digestion and absorption_Homo sapiens_hsa049750.66245869
99Regulation of autophagy_Homo sapiens_hsa041400.65343941
100Graft-versus-host disease_Homo sapiens_hsa053320.65239058
101Arginine and proline metabolism_Homo sapiens_hsa003300.63216730
102Rheumatoid arthritis_Homo sapiens_hsa053230.63208613
103HIF-1 signaling pathway_Homo sapiens_hsa040660.61875657
104cAMP signaling pathway_Homo sapiens_hsa040240.60692135
105Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.60365166
106ABC transporters_Homo sapiens_hsa020100.56916010
107Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.55847455
108Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.54838913
109Glucagon signaling pathway_Homo sapiens_hsa049220.54644529
110Amphetamine addiction_Homo sapiens_hsa050310.54405177
111Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.53392719
112Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.52567493
113Type II diabetes mellitus_Homo sapiens_hsa049300.51005114
114Glycerolipid metabolism_Homo sapiens_hsa005610.49743822
115Thyroid hormone signaling pathway_Homo sapiens_hsa049190.49119844
116Phenylalanine metabolism_Homo sapiens_hsa003600.48887650
117Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.47693127
118Viral myocarditis_Homo sapiens_hsa054160.45720297
119Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.45121218
120Pyrimidine metabolism_Homo sapiens_hsa002400.44993420
121Cocaine addiction_Homo sapiens_hsa050300.44833012
122Hematopoietic cell lineage_Homo sapiens_hsa046400.43758001
123Insulin resistance_Homo sapiens_hsa049310.43742250
124Hedgehog signaling pathway_Homo sapiens_hsa043400.39930704
125SNARE interactions in vesicular transport_Homo sapiens_hsa041300.39920943
126Pancreatic secretion_Homo sapiens_hsa049720.39508299
127Retinol metabolism_Homo sapiens_hsa008300.39354378
128Sulfur relay system_Homo sapiens_hsa041220.39179781
129Nucleotide excision repair_Homo sapiens_hsa034200.38885650
130AMPK signaling pathway_Homo sapiens_hsa041520.37335523
131Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.36358552
132Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.36331266
133Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.35665482
134Long-term depression_Homo sapiens_hsa047300.34580063
135Metabolic pathways_Homo sapiens_hsa011000.33678171
136Insulin signaling pathway_Homo sapiens_hsa049100.32041182
137Adipocytokine signaling pathway_Homo sapiens_hsa049200.31739470
138Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.28610106
139Gap junction_Homo sapiens_hsa045400.28055143
140Purine metabolism_Homo sapiens_hsa002300.25470693
141Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.25249769
142Steroid hormone biosynthesis_Homo sapiens_hsa001400.24102864
143Tyrosine metabolism_Homo sapiens_hsa003500.23927229
144Dopaminergic synapse_Homo sapiens_hsa047280.22947082
145Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.21272294
146Ovarian steroidogenesis_Homo sapiens_hsa049130.17247029
147Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.16938938
148Inositol phosphate metabolism_Homo sapiens_hsa005620.15839712
149Longevity regulating pathway - mammal_Homo sapiens_hsa042110.15676169
150Gastric acid secretion_Homo sapiens_hsa049710.15363155
151Mineral absorption_Homo sapiens_hsa049780.13747346
152Linoleic acid metabolism_Homo sapiens_hsa005910.13481894
153alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.12698091

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