LRTM2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)6.18092448
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.95903376
3locomotory exploration behavior (GO:0035641)5.70442463
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.45851363
5synaptic vesicle exocytosis (GO:0016079)5.33389903
6cellular potassium ion homeostasis (GO:0030007)5.10716751
7positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.09972986
8vocalization behavior (GO:0071625)5.06793311
9regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.00091268
10synaptic vesicle docking involved in exocytosis (GO:0016081)4.77375202
11neurotransmitter-gated ion channel clustering (GO:0072578)4.72932857
12regulation of glutamate receptor signaling pathway (GO:1900449)4.71575163
13regulation of synaptic vesicle exocytosis (GO:2000300)4.71505189
14sodium ion export (GO:0071436)4.69959791
15glutamate secretion (GO:0014047)4.67555638
16regulation of synapse structural plasticity (GO:0051823)4.61311102
17protein localization to synapse (GO:0035418)4.52077417
18neurotransmitter secretion (GO:0007269)4.37401170
19ionotropic glutamate receptor signaling pathway (GO:0035235)4.37363307
20exploration behavior (GO:0035640)4.35787680
21negative regulation of dendrite morphogenesis (GO:0050774)4.33760803
22regulation of neuronal synaptic plasticity (GO:0048168)4.33054447
23cerebellar granule cell differentiation (GO:0021707)4.32712279
24positive regulation of dendritic spine development (GO:0060999)4.27473020
25regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.22294224
26regulation of synaptic vesicle transport (GO:1902803)4.18936310
27regulation of long-term neuronal synaptic plasticity (GO:0048169)4.18388431
28gamma-aminobutyric acid transport (GO:0015812)4.15352088
29membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.12419394
30behavioral response to cocaine (GO:0048148)4.11412434
31synaptic transmission, glutamatergic (GO:0035249)4.09307590
32glutamate receptor signaling pathway (GO:0007215)4.08702947
33regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.04010519
34layer formation in cerebral cortex (GO:0021819)4.01030683
35positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.98042780
36G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.97869832
37proline transport (GO:0015824)3.97010339
38L-amino acid import (GO:0043092)3.94648517
39response to histamine (GO:0034776)3.93862630
40long-term memory (GO:0007616)3.92944209
41positive regulation of dendritic spine morphogenesis (GO:0061003)3.89308910
42neuronal action potential propagation (GO:0019227)3.88412444
43response to auditory stimulus (GO:0010996)3.86404643
44neuron-neuron synaptic transmission (GO:0007270)3.86257319
45neuron cell-cell adhesion (GO:0007158)3.85005794
46cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.84515484
47cell communication by electrical coupling (GO:0010644)3.83860576
48G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.82726036
49regulation of dendritic spine development (GO:0060998)3.76468687
50regulation of synaptic transmission, glutamatergic (GO:0051966)3.74374238
51prepulse inhibition (GO:0060134)3.74055844
52auditory behavior (GO:0031223)3.72534027
53dendritic spine morphogenesis (GO:0060997)3.72072728
54positive regulation of synaptic transmission, GABAergic (GO:0032230)3.69972437
55regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.62083249
56regulation of excitatory postsynaptic membrane potential (GO:0060079)3.61905142
57neurotransmitter transport (GO:0006836)3.58821713
58positive regulation of membrane potential (GO:0045838)3.58267839
59long-term synaptic potentiation (GO:0060291)3.50789250
60potassium ion homeostasis (GO:0055075)3.50493431
61regulation of synaptic plasticity (GO:0048167)3.49925658
62positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.49183225
63neuromuscular process controlling balance (GO:0050885)3.49081432
64regulation of synapse maturation (GO:0090128)3.48407029
65negative regulation of cytosolic calcium ion concentration (GO:0051481)3.47916117
66positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.47821148
67neuromuscular process controlling posture (GO:0050884)3.47519282
68regulation of postsynaptic membrane potential (GO:0060078)3.45744699
69transmission of nerve impulse (GO:0019226)3.44539596
70positive regulation of synapse maturation (GO:0090129)3.42354627
71regulation of ARF protein signal transduction (GO:0032012)3.41586225
72gamma-aminobutyric acid signaling pathway (GO:0007214)3.39041221
73negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.37952001
74regulation of neurotransmitter levels (GO:0001505)3.36603554
75amino acid import (GO:0043090)3.36195264
76potassium ion import (GO:0010107)3.35230012
77cerebellar Purkinje cell differentiation (GO:0021702)3.34941851
78regulation of dendritic spine morphogenesis (GO:0061001)3.34561494
79central nervous system myelination (GO:0022010)3.33726477
80axon ensheathment in central nervous system (GO:0032291)3.33726477
81cellular sodium ion homeostasis (GO:0006883)3.32238776
82presynaptic membrane organization (GO:0097090)3.29042933
83striatum development (GO:0021756)3.27074602
84glycine transport (GO:0015816)3.26996987
85membrane hyperpolarization (GO:0060081)3.26973250
86alanine transport (GO:0032328)3.26123494
87regulation of neurotransmitter secretion (GO:0046928)3.24209506
88negative regulation of synaptic transmission, GABAergic (GO:0032229)3.23730498
89neurotransmitter uptake (GO:0001504)3.23425610
90activation of protein kinase A activity (GO:0034199)3.23352451
91acidic amino acid transport (GO:0015800)3.23277792
92synaptic vesicle endocytosis (GO:0048488)3.22618855
93positive regulation of neurotransmitter transport (GO:0051590)3.22170762
94C4-dicarboxylate transport (GO:0015740)3.17683386
95regulation of vesicle fusion (GO:0031338)3.16364544
96behavioral fear response (GO:0001662)3.12536655
97behavioral defense response (GO:0002209)3.12536655
98positive regulation of synaptic transmission (GO:0050806)3.12468304
99regulation of neurotransmitter transport (GO:0051588)3.10426993
100positive regulation of neurotransmitter secretion (GO:0001956)3.09486405
101visual learning (GO:0008542)3.09243238
102cell migration in hindbrain (GO:0021535)3.08283778
103neuromuscular process (GO:0050905)3.07830388
104potassium ion transmembrane transport (GO:0071805)3.07249163
105cellular potassium ion transport (GO:0071804)3.07249163
106dendrite morphogenesis (GO:0048813)3.06659036
107fear response (GO:0042596)3.05192454
108visual behavior (GO:0007632)3.04978354
109regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.04418591
110regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.04418591
111learning (GO:0007612)3.02781603
112postsynaptic membrane organization (GO:0001941)2.98903936
113membrane depolarization during action potential (GO:0086010)2.97779096
114regulation of synaptic transmission (GO:0050804)2.97348894
115membrane depolarization (GO:0051899)2.97314400
116positive regulation of potassium ion transmembrane transport (GO:1901381)2.96691699
117neuronal ion channel clustering (GO:0045161)2.95119905
118negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.92669695
119synaptic transmission (GO:0007268)2.90600134
120regulation of voltage-gated calcium channel activity (GO:1901385)2.89764791
121synapse assembly (GO:0007416)2.89660523
122membrane repolarization (GO:0086009)2.89082858

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.12939127
2GBX2_23144817_ChIP-Seq_PC3_Human3.25941605
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.19913093
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.14890152
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.97741130
6* RARB_27405468_Chip-Seq_BRAIN_Mouse2.81111230
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.76374507
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.76374507
9* REST_21632747_ChIP-Seq_MESCs_Mouse2.75317519
10DROSHA_22980978_ChIP-Seq_HELA_Human2.73903875
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.70368467
12MTF2_20144788_ChIP-Seq_MESCs_Mouse2.61637210
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.61053089
14* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.60325099
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.59400887
16IKZF1_21737484_ChIP-ChIP_HCT116_Human2.48923720
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.46250740
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.40207384
19SUZ12_27294783_Chip-Seq_ESCs_Mouse2.35538878
20GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.33726603
21* EZH2_27294783_Chip-Seq_ESCs_Mouse2.33150448
22REST_18959480_ChIP-ChIP_MESCs_Mouse2.29087064
23EED_16625203_ChIP-ChIP_MESCs_Mouse2.28250379
24RNF2_27304074_Chip-Seq_ESCs_Mouse2.24684657
25AR_21572438_ChIP-Seq_LNCaP_Human2.03475253
26EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.03405823
27CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.01495725
28MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.98919286
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.93461781
30ERG_21242973_ChIP-ChIP_JURKAT_Human1.70292551
31NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.65014287
32SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.57362120
33CTBP2_25329375_ChIP-Seq_LNCAP_Human1.55128974
34SMAD4_21799915_ChIP-Seq_A2780_Human1.46407808
35GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40739605
36CTBP1_25329375_ChIP-Seq_LNCAP_Human1.38111395
37DNAJC2_21179169_ChIP-ChIP_NT2_Human1.37916126
38RING1B_27294783_Chip-Seq_ESCs_Mouse1.37451528
39* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.32309554
40PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.31943447
41SRY_22984422_ChIP-ChIP_TESTIS_Rat1.29326508
42PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.28545599
43AR_19668381_ChIP-Seq_PC3_Human1.26529526
44SMAD_19615063_ChIP-ChIP_OVARY_Human1.26020507
45SOX2_21211035_ChIP-Seq_LN229_Gbm1.25470385
46WT1_25993318_ChIP-Seq_PODOCYTE_Human1.25178628
47TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.25057496
48TAF15_26573619_Chip-Seq_HEK293_Human1.25016791
49RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.23124986
50NR3C1_23031785_ChIP-Seq_PC12_Mouse1.20539159
51AR_25329375_ChIP-Seq_VCAP_Human1.19592706
52SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.18655414
53TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17765727
54GATA1_26923725_Chip-Seq_HPCs_Mouse1.17624842
55SMAD3_21741376_ChIP-Seq_EPCs_Human1.17094896
56P300_19829295_ChIP-Seq_ESCs_Human1.16349732
57P53_22127205_ChIP-Seq_FIBROBLAST_Human1.15649649
58VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.13154315
59STAT3_23295773_ChIP-Seq_U87_Human1.12986692
60KDM2B_26808549_Chip-Seq_K562_Human1.12739280
61CBX2_27304074_Chip-Seq_ESCs_Mouse1.12179100
62EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.11134853
63ZFP281_18757296_ChIP-ChIP_E14_Mouse1.10829380
64RING1B_27294783_Chip-Seq_NPCs_Mouse1.10409840
65ESR2_21235772_ChIP-Seq_MCF-7_Human1.09775676
66ZFP57_27257070_Chip-Seq_ESCs_Mouse1.08726384
67TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.06571256
68WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.04184754
69ZNF217_24962896_ChIP-Seq_MCF-7_Human1.03084796
70ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.02824315
71RXR_22108803_ChIP-Seq_LS180_Human1.02422982
72SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02241824
73TP53_20018659_ChIP-ChIP_R1E_Mouse1.01394294
74YAP1_20516196_ChIP-Seq_MESCs_Mouse1.01081295
75* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.00852889
76PIAS1_25552417_ChIP-Seq_VCAP_Human1.00188034
77MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.99759818
78CDX2_19796622_ChIP-Seq_MESCs_Mouse0.99181827
79RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.98528036
80THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.98188850
81DPY_21335234_ChIP-Seq_ESCs_Mouse0.97915891
82NR3C1_21868756_ChIP-Seq_MCF10A_Human0.96953704
83OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.96933402
84* TCF4_23295773_ChIP-Seq_U87_Human0.96024992
85GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95800931
86OCT4_19829295_ChIP-Seq_ESCs_Human0.95691933
87PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.95508325
88TOP2B_26459242_ChIP-Seq_MCF-7_Human0.94662156
89CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.94635327
90ZNF274_21170338_ChIP-Seq_K562_Hela0.94364612
91SMAD4_21741376_ChIP-Seq_HESCs_Human0.93286759
92ARNT_22903824_ChIP-Seq_MCF-7_Human0.91488314
93SMAD3_21741376_ChIP-Seq_ESCs_Human0.91337712
94* OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.90974589
95CTNNB1_20460455_ChIP-Seq_HCT116_Human0.90057231
96TET1_21490601_ChIP-Seq_MESCs_Mouse0.89393417
97* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.88545972
98LXR_22292898_ChIP-Seq_THP-1_Human0.88474966
99AHR_22903824_ChIP-Seq_MCF-7_Human0.88434101
100CTCF_27219007_Chip-Seq_Bcells_Human0.87813758
101SMAD3_21741376_ChIP-Seq_HESCs_Human0.87638394
102CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86917932
103TP53_16413492_ChIP-PET_HCT116_Human0.86730705
104SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86008731
105* SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.85286519
106RNF2_27304074_Chip-Seq_NSC_Mouse0.85131713
107KLF4_19829295_ChIP-Seq_ESCs_Human0.84632629
108TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.84477240
109* SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.84309427
110* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.83352240
111TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.82597424
112BMI1_23680149_ChIP-Seq_NPCS_Mouse0.82540058
113RUNX2_22187159_ChIP-Seq_PCA_Human0.82539511
114LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.81205806
115TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.79098877
116GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.78096903
117EGR1_19032775_ChIP-ChIP_M12_Human0.77814315
118* KDM2B_26808549_Chip-Seq_SUP-B15_Human0.76725302
119FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.76259921
120* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.76205796
121POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.75831327
122TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.75831327
123PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.74418359
124KDM2B_26808549_Chip-Seq_REH_Human0.74136794

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.28602257
2MP0003880_abnormal_central_pattern4.22161950
3MP0003635_abnormal_synaptic_transmissio4.10798305
4MP0002822_catalepsy4.09550377
5MP0009745_abnormal_behavioral_response3.48853275
6MP0002063_abnormal_learning/memory/cond3.32183752
7MP0002064_seizures3.23162989
8MP0009046_muscle_twitch3.21981839
9MP0004270_analgesia3.10861087
10MP0005423_abnormal_somatic_nervous3.02018787
11MP0001486_abnormal_startle_reflex2.92034383
12MP0002572_abnormal_emotion/affect_behav2.85714950
13MP0001968_abnormal_touch/_nociception2.66498210
14MP0002272_abnormal_nervous_system2.57812069
15MP0002734_abnormal_mechanical_nocicepti2.37314747
16MP0005646_abnormal_pituitary_gland2.28181870
17MP0001501_abnormal_sleep_pattern2.20137307
18MP0008569_lethality_at_weaning2.19178547
19MP0001984_abnormal_olfaction2.18416612
20MP0002909_abnormal_adrenal_gland2.16580095
21MP0002736_abnormal_nociception_after1.97727751
22MP0003329_amyloid_beta_deposits1.94562731
23MP0001502_abnormal_circadian_rhythm1.92223773
24MP0001440_abnormal_grooming_behavior1.89541634
25MP0002067_abnormal_sensory_capabilities1.88266728
26MP0004885_abnormal_endolymph1.84347152
27MP0002733_abnormal_thermal_nociception1.83337328
28MP0004858_abnormal_nervous_system1.81322944
29MP0001970_abnormal_pain_threshold1.80484568
30MP0002557_abnormal_social/conspecific_i1.80471438
31MP0009780_abnormal_chondrocyte_physiolo1.77756337
32MP0005386_behavior/neurological_phenoty1.74128869
33MP0004924_abnormal_behavior1.74128869
34MP0005551_abnormal_eye_electrophysiolog1.72135373
35MP0002735_abnormal_chemical_nociception1.60629864
36MP0004811_abnormal_neuron_physiology1.59702387
37MP0001529_abnormal_vocalization1.55718537
38MP0003690_abnormal_glial_cell1.53499533
39MP0003633_abnormal_nervous_system1.53348334
40MP0005645_abnormal_hypothalamus_physiol1.53306132
41MP0002184_abnormal_innervation1.50086503
42MP0003879_abnormal_hair_cell1.49626065
43MP0000778_abnormal_nervous_system1.42968793
44MP0000955_abnormal_spinal_cord1.40151252
45MP0003787_abnormal_imprinting1.39979642
46MP0002882_abnormal_neuron_morphology1.39862469
47MP0002066_abnormal_motor_capabilities/c1.38585060
48MP0002090_abnormal_vision1.35473474
49MP0003123_paternal_imprinting1.30936988
50MP0004142_abnormal_muscle_tone1.29511637
51MP0003075_altered_response_to1.27165559
52MP0003631_nervous_system_phenotype1.26725951
53MP0001905_abnormal_dopamine_level1.17407744
54MP0006276_abnormal_autonomic_nervous1.16581498
55MP0002229_neurodegeneration1.13915871
56MP0002638_abnormal_pupillary_reflex1.11542641
57MP0003122_maternal_imprinting1.07793460
58MP0002152_abnormal_brain_morphology1.06682828
59MP0008872_abnormal_physiological_respon1.04400046
60MP0003634_abnormal_glial_cell1.03330992
61MP0008877_abnormal_DNA_methylation1.00691242
62MP0008874_decreased_physiological_sensi0.99204757
63MP0002069_abnormal_eating/drinking_beha0.97894887
64MP0000751_myopathy0.95736431
65MP0005167_abnormal_blood-brain_barrier0.95588289
66MP0001177_atelectasis0.94925361
67MP0008961_abnormal_basal_metabolism0.92159687
68MP0000013_abnormal_adipose_tissue0.91974852
69MP0003632_abnormal_nervous_system0.90260049
70MP0000604_amyloidosis0.89304470
71MP0005394_taste/olfaction_phenotype0.88721507
72MP0005499_abnormal_olfactory_system0.88721507
73MP0000920_abnormal_myelination0.87563734
74MP0004742_abnormal_vestibular_system0.85075738
75MP0006072_abnormal_retinal_apoptosis0.85062434
76MP0005253_abnormal_eye_physiology0.84607363
77MP0004085_abnormal_heartbeat0.83049579
78MP0010386_abnormal_urinary_bladder0.81919086
79MP0005535_abnormal_body_temperature0.81798449
80MP0004215_abnormal_myocardial_fiber0.81249687
81MP0001963_abnormal_hearing_physiology0.80600985
82MP0001485_abnormal_pinna_reflex0.79294090
83MP0003172_abnormal_lysosome_physiology0.77345060
84MP0003183_abnormal_peptide_metabolism0.76911250
85MP0002752_abnormal_somatic_nervous0.76644064
86MP0001188_hyperpigmentation0.75376967
87MP0003137_abnormal_impulse_conducting0.74779143
88MP0004233_abnormal_muscle_weight0.73334473
89MP0001346_abnormal_lacrimal_gland0.73129216
90MP0004510_myositis0.73049397
91MP0000631_abnormal_neuroendocrine_gland0.73027950
92MP0004147_increased_porphyrin_level0.69116936
93MP0000566_synostosis0.68423281
94MP0003646_muscle_fatigue0.65172878
95MP0000026_abnormal_inner_ear0.62692193
96MP0003283_abnormal_digestive_organ0.62009956
97MP0004043_abnormal_pH_regulation0.61546948
98MP0001986_abnormal_taste_sensitivity0.59695828
99MP0001299_abnormal_eye_distance/0.58188641
100MP0000569_abnormal_digit_pigmentation0.57636016
101MP0000579_abnormal_nail_morphology0.56216776
102MP0005623_abnormal_meninges_morphology0.55825008
103MP0001664_abnormal_digestion0.55111839
104MP0005409_darkened_coat_color0.54850725
105MP0005171_absent_coat_pigmentation0.54491837
106MP0001348_abnormal_lacrimal_gland0.53841494
107MP0008875_abnormal_xenobiotic_pharmacok0.53469097
108MP0003956_abnormal_body_size0.53118434
109MP0004145_abnormal_muscle_electrophysio0.51582473
110MP0004130_abnormal_muscle_cell0.51121243
111MP0005166_decreased_susceptibility_to0.50964670
112MP0010769_abnormal_survival0.50463660
113MP0005195_abnormal_posterior_eye0.50273572
114MP0010770_preweaning_lethality0.48458447
115MP0002082_postnatal_lethality0.48458447
116MP0001765_abnormal_ion_homeostasis0.48329178
117MP0010768_mortality/aging0.46994514
118MP0001943_abnormal_respiration0.46518130
119MP0003938_abnormal_ear_development0.46086545
120MP0000747_muscle_weakness0.44776911

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.49416528
2Myokymia (HP:0002411)7.44652911
3Focal seizures (HP:0007359)5.44299316
4Epileptic encephalopathy (HP:0200134)5.01002577
5Visual hallucinations (HP:0002367)4.66653744
6Action tremor (HP:0002345)4.54592244
7Progressive cerebellar ataxia (HP:0002073)4.49708901
8Absence seizures (HP:0002121)4.27560792
9Febrile seizures (HP:0002373)4.07096020
10Atonic seizures (HP:0010819)4.02336158
11Generalized tonic-clonic seizures (HP:0002069)4.01184382
12Dialeptic seizures (HP:0011146)3.88297082
13Dysdiadochokinesis (HP:0002075)3.84164007
14Depression (HP:0000716)3.67226042
15Megalencephaly (HP:0001355)3.53129466
16Cerebral hypomyelination (HP:0006808)3.47008145
17Postural instability (HP:0002172)3.45693709
18Ankle clonus (HP:0011448)3.44634471
19Supranuclear gaze palsy (HP:0000605)3.39464547
20Anxiety (HP:0000739)3.36364117
21Abnormal eating behavior (HP:0100738)3.27712695
22Sensory axonal neuropathy (HP:0003390)3.24066185
23Poor eye contact (HP:0000817)3.24062153
24Delusions (HP:0000746)3.24054953
25Urinary bladder sphincter dysfunction (HP:0002839)3.24039057
26Hemiplegia (HP:0002301)3.19357632
27Hemiparesis (HP:0001269)3.17564317
28Torticollis (HP:0000473)3.15963586
29Gaze-evoked nystagmus (HP:0000640)3.13749352
30Dysmetria (HP:0001310)3.07920326
31Impaired vibration sensation in the lower limbs (HP:0002166)3.06434684
32Apathy (HP:0000741)3.06189295
33Truncal ataxia (HP:0002078)3.05353586
34Abnormal social behavior (HP:0012433)3.04905435
35Impaired social interactions (HP:0000735)3.04905435
36Broad-based gait (HP:0002136)3.00460120
37Abnormality of the corticospinal tract (HP:0002492)2.99323825
38Abnormality of binocular vision (HP:0011514)2.93308546
39Diplopia (HP:0000651)2.93308546
40Neurofibrillary tangles (HP:0002185)2.89564125
41Genetic anticipation (HP:0003743)2.86530733
42Mutism (HP:0002300)2.83882797
43Akinesia (HP:0002304)2.81500483
44Status epilepticus (HP:0002133)2.79349565
45Focal dystonia (HP:0004373)2.79271551
46Diminished motivation (HP:0000745)2.77785414
47Spastic tetraparesis (HP:0001285)2.73618788
48Aplasia involving bones of the extremities (HP:0009825)2.72283451
49Aplasia involving bones of the upper limbs (HP:0009823)2.72283451
50Aplasia of the phalanges of the hand (HP:0009802)2.72283451
51Obstructive sleep apnea (HP:0002870)2.71248454
52Bradykinesia (HP:0002067)2.67190481
53Degeneration of the lateral corticospinal tracts (HP:0002314)2.60754894
54Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.60754894
55Intention tremor (HP:0002080)2.60004179
56Hyperventilation (HP:0002883)2.59501376
57Craniofacial dystonia (HP:0012179)2.57635882
58Scanning speech (HP:0002168)2.57355534
59Slow saccadic eye movements (HP:0000514)2.55291744
60Peripheral hypomyelination (HP:0007182)2.53355857
61Stereotypic behavior (HP:0000733)2.52621979
62Papilledema (HP:0001085)2.52075751
63Dysmetric saccades (HP:0000641)2.51241363
64Spastic gait (HP:0002064)2.48879590
65Increased circulating renin level (HP:0000848)2.47534561
66Polyphagia (HP:0002591)2.43522845
67Cerebral inclusion bodies (HP:0100314)2.40628440
68Annular pancreas (HP:0001734)2.39479630
69Ventricular fibrillation (HP:0001663)2.39269297
70Urinary urgency (HP:0000012)2.39074659
71Epileptiform EEG discharges (HP:0011182)2.36089776
72Choreoathetosis (HP:0001266)2.35200281
73Central scotoma (HP:0000603)2.35007058
74EEG with generalized epileptiform discharges (HP:0011198)2.31076954
75Abnormality of the lower motor neuron (HP:0002366)2.30832955
76Drooling (HP:0002307)2.30547823
77Excessive salivation (HP:0003781)2.30547823
78Impaired smooth pursuit (HP:0007772)2.28396153
79Split foot (HP:0001839)2.26179361
80Impaired vibratory sensation (HP:0002495)2.24140578
81Abnormality of ocular smooth pursuit (HP:0000617)2.23129586
82Abnormal EKG (HP:0003115)2.21820009
83Congenital stationary night blindness (HP:0007642)2.19831791
84Prolonged QT interval (HP:0001657)2.18234589
85Sleep apnea (HP:0010535)2.18131438
86Rigidity (HP:0002063)2.17110412
87Pointed chin (HP:0000307)2.16952560
88Generalized myoclonic seizures (HP:0002123)2.15737291
89Morphological abnormality of the pyramidal tract (HP:0002062)2.15155522
90Lower limb muscle weakness (HP:0007340)2.12325733
91Amblyopia (HP:0000646)2.11150321
92Clumsiness (HP:0002312)2.09816104
93Hypsarrhythmia (HP:0002521)2.08777254
94Incomplete penetrance (HP:0003829)2.03663210
95Clonus (HP:0002169)2.02011186
96Insomnia (HP:0100785)2.01343225
97Rapidly progressive (HP:0003678)2.00601215
98Limb dystonia (HP:0002451)1.98070013
99Pheochromocytoma (HP:0002666)1.97812500
100Fetal akinesia sequence (HP:0001989)1.95157520
101Abnormality of saccadic eye movements (HP:0000570)1.94387577
102Memory impairment (HP:0002354)1.89943820
103Tetraplegia (HP:0002445)1.89824272
104Psychosis (HP:0000709)1.89418575
105Spinal canal stenosis (HP:0003416)1.89048419
106Resting tremor (HP:0002322)1.88661920
107Blue irides (HP:0000635)1.88485328
108Neuronal loss in central nervous system (HP:0002529)1.88069006
109Gait ataxia (HP:0002066)1.85974394
110CNS hypomyelination (HP:0003429)1.82527758
111Progressive inability to walk (HP:0002505)1.81221096
112Bundle branch block (HP:0011710)1.81002132
113Limb ataxia (HP:0002070)1.80965160
114Abnormality of the periventricular white matter (HP:0002518)1.79407044
115Dementia (HP:0000726)1.77883278
116Postural tremor (HP:0002174)1.76374152
117Ankyloglossia (HP:0010296)1.75766874
118Neoplasm of the heart (HP:0100544)1.75481237
119Failure to thrive in infancy (HP:0001531)1.74386740
120Severe global developmental delay (HP:0011344)1.70080126
121Scotoma (HP:0000575)1.69448750
122Absent speech (HP:0001344)1.65003755

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA45.49408099
2NTRK34.08078745
3MAP3K93.38196719
4PRKD32.73502390
5MAP3K42.59607511
6NTRK22.46546644
7MINK12.45569131
8DAPK22.30690592
9MARK12.29822209
10MAP2K72.24009023
11PAK62.20983061
12TNIK2.06113959
13KSR22.01500639
14CAMKK12.01398137
15PRPF4B1.69826324
16NTRK11.69198550
17IRAK21.65559186
18MAP2K41.64636080
19STK381.56823136
20CDK51.54598646
21SGK2231.49339751
22SGK4941.49339751
23RIPK41.46728700
24MAP3K131.45311099
25PHKG11.44287172
26PHKG21.44287172
27SGK21.43991285
28KSR11.43554740
29LMTK21.40480979
30FES1.40387861
31ARAF1.39098784
32MAP3K121.35633050
33PINK11.33697861
34SGK31.26871119
35MAPK131.25500005
36DAPK11.23958849
37PRKCG1.17616671
38PLK21.14512496
39PRKCH1.10405658
40SIK21.09911878
41CASK1.09634362
42CDK191.06957737
43CAMKK21.06152936
44TYRO31.02034067
45CAMK10.99387248
46GRK50.97460343
47TAOK10.96366522
48MUSK0.96231283
49UHMK10.94203005
50CDK180.93483985
51CDK150.92553328
52CAMK2A0.91094806
53CDK140.88569544
54TNK20.87605633
55MAP3K20.87368599
56TRIB30.83921680
57BRD40.83161982
58MARK20.81432646
59ALK0.80737407
60CDK11A0.79962776
61DAPK30.78975298
62SGK10.76859124
63STK110.74004539
64RAF10.72837782
65PAK30.70596278
66RIPK10.69124771
67DYRK1A0.67789286
68CAMK1G0.66459540
69MAP3K70.66271970
70PKN10.65996442
71PDK10.65696518
72PDPK10.65565773
73NEK60.64258569
74CAMK2B0.62883742
75NEK10.62121479
76RET0.62045976
77WNK30.61248558
78BRAF0.59472260
79CAMK1D0.57382507
80RPS6KA30.56774261
81PNCK0.56745207
82MAP3K110.55605522
83OXSR10.55169641
84MAP3K10.55023899
85SIK30.54949952
86MOS0.54148298
87LIMK10.53389032
88PRKCE0.52001015
89CAMK40.51287453
90PRKCZ0.48244173
91PDK20.48066310
92CCNB10.47494603
93DMPK0.47268776
94BMPR20.46615278
95LATS20.46274906
96TAOK20.44904327
97MAPK100.44738627
98CDC42BPA0.43751581
99FYN0.43173885
100CAMK2G0.43025832
101CAMK2D0.41297020
102MAPK120.39839037
103PTK2B0.39191779
104PRKD20.39139315
105PRKCA0.39136112
106ADRBK10.38419340
107CSNK1G20.37519258
108WNK10.36656631
109PRKCB0.35582448
110MAP2K10.34193219
111BRSK10.33588804
112PRKCQ0.30080807
113ERBB30.28320870
114JAK20.26598009
115MAP2K60.24414631
116TESK10.22156042
117PRKCD0.21965925
118RPS6KB10.20889236
119SRC0.19332274

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.73635610
2Nitrogen metabolism_Homo sapiens_hsa009103.49473419
3Synaptic vesicle cycle_Homo sapiens_hsa047213.32009670
4GABAergic synapse_Homo sapiens_hsa047272.98895963
5Olfactory transduction_Homo sapiens_hsa047402.78362395
6Morphine addiction_Homo sapiens_hsa050322.64121608
7Circadian entrainment_Homo sapiens_hsa047132.61710820
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.55777383
9Glutamatergic synapse_Homo sapiens_hsa047242.53746057
10Long-term potentiation_Homo sapiens_hsa047202.27222860
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.25386312
12Salivary secretion_Homo sapiens_hsa049702.10799871
13Amphetamine addiction_Homo sapiens_hsa050312.09964813
14Insulin secretion_Homo sapiens_hsa049112.02249095
15Dopaminergic synapse_Homo sapiens_hsa047281.96103990
16Cholinergic synapse_Homo sapiens_hsa047251.90101093
17Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.85020891
18Gastric acid secretion_Homo sapiens_hsa049711.81057077
19Cocaine addiction_Homo sapiens_hsa050301.77638884
20Aldosterone synthesis and secretion_Homo sapiens_hsa049251.65759655
21Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.59173559
22Calcium signaling pathway_Homo sapiens_hsa040201.56131601
23Serotonergic synapse_Homo sapiens_hsa047261.53511361
24Renin secretion_Homo sapiens_hsa049241.52548069
25Taste transduction_Homo sapiens_hsa047421.51039212
26Oxytocin signaling pathway_Homo sapiens_hsa049211.47493421
27Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.43738939
28Long-term depression_Homo sapiens_hsa047301.38127532
29Vitamin B6 metabolism_Homo sapiens_hsa007501.30902779
30cAMP signaling pathway_Homo sapiens_hsa040241.25264641
31Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.22839994
32GnRH signaling pathway_Homo sapiens_hsa049121.21572876
33Collecting duct acid secretion_Homo sapiens_hsa049661.19784417
34Gap junction_Homo sapiens_hsa045401.19083815
35Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.18182061
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.11236550
37Type II diabetes mellitus_Homo sapiens_hsa049301.04231675
38Phototransduction_Homo sapiens_hsa047440.96922466
39Glioma_Homo sapiens_hsa052140.95955938
40cGMP-PKG signaling pathway_Homo sapiens_hsa040220.94914875
41Phospholipase D signaling pathway_Homo sapiens_hsa040720.94362240
42Phosphatidylinositol signaling system_Homo sapiens_hsa040700.94111733
43Estrogen signaling pathway_Homo sapiens_hsa049150.93491672
44Circadian rhythm_Homo sapiens_hsa047100.90273761
45Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.87919418
46Axon guidance_Homo sapiens_hsa043600.84614049
47ErbB signaling pathway_Homo sapiens_hsa040120.84240780
48Cardiac muscle contraction_Homo sapiens_hsa042600.84110315
49Melanogenesis_Homo sapiens_hsa049160.83902155
50Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.82862860
51Pancreatic secretion_Homo sapiens_hsa049720.82661944
52Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.80481067
53Carbohydrate digestion and absorption_Homo sapiens_hsa049730.79929621
54Vascular smooth muscle contraction_Homo sapiens_hsa042700.79691728
55Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.76869541
56Fatty acid biosynthesis_Homo sapiens_hsa000610.76110657
57Bile secretion_Homo sapiens_hsa049760.74551551
58Dorso-ventral axis formation_Homo sapiens_hsa043200.72698702
59Thyroid hormone synthesis_Homo sapiens_hsa049180.72384941
60Dilated cardiomyopathy_Homo sapiens_hsa054140.71962455
61Thyroid hormone signaling pathway_Homo sapiens_hsa049190.66964110
62Vibrio cholerae infection_Homo sapiens_hsa051100.66722792
63Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.66318478
64Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.64566366
65Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.64056328
66Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.61311114
67Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.61095843
68MAPK signaling pathway_Homo sapiens_hsa040100.57984666
69Choline metabolism in cancer_Homo sapiens_hsa052310.57599663
70Arginine and proline metabolism_Homo sapiens_hsa003300.56731423
71Oocyte meiosis_Homo sapiens_hsa041140.54636016
72Rap1 signaling pathway_Homo sapiens_hsa040150.53570741
73Neurotrophin signaling pathway_Homo sapiens_hsa047220.53443940
74Glucagon signaling pathway_Homo sapiens_hsa049220.51638217
75Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.50891064
76Arginine biosynthesis_Homo sapiens_hsa002200.50050537
77Ras signaling pathway_Homo sapiens_hsa040140.48237786
78Sphingolipid signaling pathway_Homo sapiens_hsa040710.48080730
79Alzheimers disease_Homo sapiens_hsa050100.47438342
80Histidine metabolism_Homo sapiens_hsa003400.46991226
81Alcoholism_Homo sapiens_hsa050340.46971990
82Type I diabetes mellitus_Homo sapiens_hsa049400.46628169
83Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.45865465
84Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.42866789
85Endocytosis_Homo sapiens_hsa041440.41841925
86Regulation of autophagy_Homo sapiens_hsa041400.41835814
87Non-small cell lung cancer_Homo sapiens_hsa052230.40599675
88Endometrial cancer_Homo sapiens_hsa052130.38739660
89VEGF signaling pathway_Homo sapiens_hsa043700.38482160
90Prion diseases_Homo sapiens_hsa050200.38078837
91Renal cell carcinoma_Homo sapiens_hsa052110.37892339
92Inositol phosphate metabolism_Homo sapiens_hsa005620.37789813
93mTOR signaling pathway_Homo sapiens_hsa041500.36788817
94Mineral absorption_Homo sapiens_hsa049780.34667942
95Longevity regulating pathway - mammal_Homo sapiens_hsa042110.34184774
96Glycerophospholipid metabolism_Homo sapiens_hsa005640.32368966
97Chemokine signaling pathway_Homo sapiens_hsa040620.32036476
98SNARE interactions in vesicular transport_Homo sapiens_hsa041300.30820014
99Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.29857219
100Insulin signaling pathway_Homo sapiens_hsa049100.29849647
101Ovarian steroidogenesis_Homo sapiens_hsa049130.29229946
102Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.27646875
103Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.26942356
104Butanoate metabolism_Homo sapiens_hsa006500.26584566
105Wnt signaling pathway_Homo sapiens_hsa043100.24435195
106Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.22906754
107HIF-1 signaling pathway_Homo sapiens_hsa040660.20639169
108Phenylalanine metabolism_Homo sapiens_hsa003600.19591866
109Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.16853347
110Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.15317795
111beta-Alanine metabolism_Homo sapiens_hsa004100.15075225
112AMPK signaling pathway_Homo sapiens_hsa041520.14698949

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