ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	axonemal dynein complex assembly (GO:0070286)	9.76737364
2	cilium or flagellum-dependent cell motility (GO:0001539)	8.46299625
3	cilium movement (GO:0003341)	8.16650945
4	epithelial cilium movement (GO:0003351)	8.03850517
5	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	7.82278242
6	motile cilium assembly (GO:0044458)	6.61057787
7	axoneme assembly (GO:0035082)	6.31746240
8	regulation of cilium movement (GO:0003352)	5.44907978
9	behavioral response to nicotine (GO:0035095)	5.17140114
10	cilium organization (GO:0044782)	4.55925892
11	intraciliary transport (GO:0042073)	4.45103052
12	cilium assembly (GO:0042384)	4.42608354
13	protein localization to cilium (GO:0061512)	4.41197605
14	left/right pattern formation (GO:0060972)	4.11413718
15	response to pheromone (GO:0019236)	4.05494634
16	cilium morphogenesis (GO:0060271)	4.02081725
17	left/right axis specification (GO:0070986)	4.01207001
18	sperm motility (GO:0030317)	3.94618316
19	regulation of microtubule-based movement (GO:0060632)	3.74945467
20	centriole replication (GO:0007099)	3.74445480
21	protein polyglutamylation (GO:0018095)	3.72931578
22	microtubule bundle formation (GO:0001578)	3.65378326
23	centriole assembly (GO:0098534)	3.53462712
24	nonmotile primary cilium assembly (GO:0035058)	3.51451645
25	negative regulation of T cell differentiation in thymus (GO:0033085)	3.50876743
26	ventricular system development (GO:0021591)	3.42575395
27	cellular component assembly involved in morphogenesis (GO:0010927)	3.39833297
28	water-soluble vitamin biosynthetic process (GO:0042364)	3.36394622
29	fucose catabolic process (GO:0019317)	3.35930470
30	L-fucose metabolic process (GO:0042354)	3.35930470
31	L-fucose catabolic process (GO:0042355)	3.35930470
32	microtubule depolymerization (GO:0007019)	3.34837490
33	cellular ketone body metabolic process (GO:0046950)	3.34625483
34	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.11571386
35	protein complex biogenesis (GO:0070271)	3.07039982
36	respiratory chain complex IV assembly (GO:0008535)	3.06091866
37	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.03778300
38	ATP synthesis coupled proton transport (GO:0015986)	3.03778300
39	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.03763356
40	multicellular organism reproduction (GO:0032504)	2.99254568
41	piRNA metabolic process (GO:0034587)	2.97791573
42	ketone body metabolic process (GO:1902224)	2.97250301
43	cornea development in camera-type eye (GO:0061303)	2.95381238
44	response to xenobiotic stimulus (GO:0009410)	2.92845880
45	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.88882198
46	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.88882198
47	NADH dehydrogenase complex assembly (GO:0010257)	2.88882198
48	ubiquinone biosynthetic process (GO:0006744)	2.88549907
49	mitochondrial respiratory chain complex assembly (GO:0033108)	2.87419789
50	preassembly of GPI anchor in ER membrane (GO:0016254)	2.87349885
51	protein-cofactor linkage (GO:0018065)	2.85054398
52	cell projection assembly (GO:0030031)	2.83185835
53	spinal cord motor neuron differentiation (GO:0021522)	2.82651784
54	DNA deamination (GO:0045006)	2.81314062
55	smoothened signaling pathway (GO:0007224)	2.80496394
56	exogenous drug catabolic process (GO:0042738)	2.77375544
57	nucleoside diphosphate phosphorylation (GO:0006165)	2.73654078
58	rRNA catabolic process (GO:0016075)	2.73412651
59	retinal cone cell development (GO:0046549)	2.72941264
60	photoreceptor cell maintenance (GO:0045494)	2.69578371
61	microtubule polymerization or depolymerization (GO:0031109)	2.68684392
62	behavioral response to ethanol (GO:0048149)	2.67625327
63	detection of light stimulus involved in sensory perception (GO:0050962)	2.66103384
64	detection of light stimulus involved in visual perception (GO:0050908)	2.66103384
65	determination of left/right symmetry (GO:0007368)	2.66008428
66	cytochrome complex assembly (GO:0017004)	2.64738341
67	ubiquinone metabolic process (GO:0006743)	2.64372064
68	neuronal action potential (GO:0019228)	2.63926852
69	one-carbon compound transport (GO:0019755)	2.62700135
70	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.62081962
71	electron transport chain (GO:0022900)	2.62049839
72	negative regulation of telomere maintenance (GO:0032205)	2.61131943
73	neural tube formation (GO:0001841)	2.60742490
74	primary alcohol catabolic process (GO:0034310)	2.60710947
75	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.59371117
76	rRNA methylation (GO:0031167)	2.58659440
77	indolalkylamine metabolic process (GO:0006586)	2.57779003
78	rRNA modification (GO:0000154)	2.56764990
79	spermatid development (GO:0007286)	2.54833287
80	microtubule-based movement (GO:0007018)	2.54151986
81	tryptophan catabolic process (GO:0006569)	2.53327731
82	indole-containing compound catabolic process (GO:0042436)	2.53327731
83	indolalkylamine catabolic process (GO:0046218)	2.53327731
84	acrosome reaction (GO:0007340)	2.51134032
85	drug catabolic process (GO:0042737)	2.48015126
86	GPI anchor metabolic process (GO:0006505)	2.47201321
87	kynurenine metabolic process (GO:0070189)	2.46946065
88	respiratory electron transport chain (GO:0022904)	2.46648551
89	platelet dense granule organization (GO:0060155)	2.46278465
90	DNA methylation involved in gamete generation (GO:0043046)	2.45090121
91	vitamin transmembrane transport (GO:0035461)	2.43525494
92	determination of bilateral symmetry (GO:0009855)	2.43507119
93	protein neddylation (GO:0045116)	2.43399567
94	sulfation (GO:0051923)	2.43063186
95	GTP biosynthetic process (GO:0006183)	2.41768368
96	mannosylation (GO:0097502)	2.41238926
97	regulation of action potential (GO:0098900)	2.38073135
98	specification of symmetry (GO:0009799)	2.37191642
99	photoreceptor cell development (GO:0042461)	2.35439579
100	sperm capacitation (GO:0048240)	2.34960824

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.68371228
2	VDR_22108803_ChIP-Seq_LS180_Human	3.28903753
3	EZH2_22144423_ChIP-Seq_EOC_Human	2.67093429
4	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.66668721
5	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.49042518
6	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.28692784
7	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.11904498
8	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.11518826
9	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.07408956
10	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	2.06012704
11	GBX2_23144817_ChIP-Seq_PC3_Human	2.04846208
12	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.97828267
13	FUS_26573619_Chip-Seq_HEK293_Human	1.95072035
14	EWS_26573619_Chip-Seq_HEK293_Human	1.93097780
15	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.92335740
16	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.89027329
17	IGF1R_20145208_ChIP-Seq_DFB_Human	1.83804967
18	ER_23166858_ChIP-Seq_MCF-7_Human	1.81502044
19	TAF15_26573619_Chip-Seq_HEK293_Human	1.79496573
20	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.78599778
21	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.77744029
22	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.76561076
23	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.74562383
24	P300_19829295_ChIP-Seq_ESCs_Human	1.72052097
25	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.69386002
26	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.64483475
27	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.61681318
28	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.55078225
29	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.53658633
30	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.53658633
31	BCAT_22108803_ChIP-Seq_LS180_Human	1.49893286
32	IRF1_19129219_ChIP-ChIP_H3396_Human	1.49043416
33	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.48040966
34	TP53_22573176_ChIP-Seq_HFKS_Human	1.47716473
35	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.45212009
36	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.45018365
37	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.43639560
38	CBP_20019798_ChIP-Seq_JUKART_Human	1.43603228
39	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.43603228
40	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.42456347
41	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.42456347
42	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.40327734
43	AR_25329375_ChIP-Seq_VCAP_Human	1.39912897
44	MYC_18940864_ChIP-ChIP_HL60_Human	1.39554166
45	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.37660827
46	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.35024187
47	AR_20517297_ChIP-Seq_VCAP_Human	1.32310503
48	STAT3_23295773_ChIP-Seq_U87_Human	1.31600786
49	SOX2_19829295_ChIP-Seq_ESCs_Human	1.30795537
50	NANOG_19829295_ChIP-Seq_ESCs_Human	1.30795537
51	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.30677498
52	SMAD4_21799915_ChIP-Seq_A2780_Human	1.30380811
53	REST_21632747_ChIP-Seq_MESCs_Mouse	1.29941797
54	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.28543653
55	NCOR_22424771_ChIP-Seq_293T_Human	1.26906199
56	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.25538410
57	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.25462184
58	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.24666525
59	HOXB7_26014856_ChIP-Seq_BT474_Human	1.24189645
60	ERA_21632823_ChIP-Seq_H3396_Human	1.23688496
61	TCF4_22108803_ChIP-Seq_LS180_Human	1.23458492
62	TCF4_23295773_ChIP-Seq_U87_Human	1.21248821
63	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.20845285
64	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.20188207
65	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.16800979
66	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.16702189
67	RUNX2_22187159_ChIP-Seq_PCA_Human	1.16633428
68	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.16362611
69	VDR_23849224_ChIP-Seq_CD4+_Human	1.14527652
70	DROSHA_22980978_ChIP-Seq_HELA_Human	1.14441835
71	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.13610738
72	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.13548364
73	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.13502995
74	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.13141874
75	RNF2_27304074_Chip-Seq_NSC_Mouse	1.11425026
76	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.10228891
77	MYC_19829295_ChIP-Seq_ESCs_Human	1.10142803
78	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.09112350
79	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.08669425
80	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.08054523
81	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.07389262
82	ETV1_20927104_ChIP-Seq_GIST48_Human	1.03557943
83	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.02936383
84	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.02767916
85	ELK1_19687146_ChIP-ChIP_HELA_Human	1.01531361
86	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.01352069
87	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.01153055
88	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.01032288
89	NANOG_20526341_ChIP-Seq_ESCs_Human	1.00820847
90	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.00060472
91	TAF2_19829295_ChIP-Seq_ESCs_Human	0.99560712
92	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.96967262
93	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.96961214
94	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.96862065
95	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.96654997
96	P53_21459846_ChIP-Seq_SAOS-2_Human	0.95478707
97	ETS1_20019798_ChIP-Seq_JURKAT_Human	0.95007626
98	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	0.94786109
99	PHF8_20622853_ChIP-Seq_HELA_Human	0.93921426
100	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.93701012

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008875_abnormal_xenobiotic_pharmacok	3.46054040
2	MP0002653_abnormal_ependyma_morphology	3.33622417
3	MP0004043_abnormal_pH_regulation	2.68120213
4	MP0003136_yellow_coat_color	2.62414015
5	MP0005551_abnormal_eye_electrophysiolog	2.32594946
6	MP0004133_heterotaxia	2.30500609
7	MP0008877_abnormal_DNA_methylation	2.13693731
8	MP0001984_abnormal_olfaction	2.12991389
9	MP0002638_abnormal_pupillary_reflex	2.09448617
10	MP0003195_calcinosis	2.07108285
11	MP0002102_abnormal_ear_morphology	2.00076319
12	MP0001968_abnormal_touch/_nociception	1.95757843
13	MP0004142_abnormal_muscle_tone	1.91776414
14	MP0002876_abnormal_thyroid_physiology	1.91631631
15	MP0002160_abnormal_reproductive_system	1.88986025
16	MP0008872_abnormal_physiological_respon	1.84139629
17	MP0002277_abnormal_respiratory_mucosa	1.82641196
18	MP0005410_abnormal_fertilization	1.82393257
19	MP0009046_muscle_twitch	1.78688781
20	MP0008789_abnormal_olfactory_epithelium	1.77077687
21	MP0001485_abnormal_pinna_reflex	1.73436124
22	MP0005646_abnormal_pituitary_gland	1.71061630
23	MP0009745_abnormal_behavioral_response	1.70933247
24	MP0005253_abnormal_eye_physiology	1.68566307
25	MP0006292_abnormal_olfactory_placode	1.68059115
26	MP0006072_abnormal_retinal_apoptosis	1.64777790
27	MP0003878_abnormal_ear_physiology	1.60999567
28	MP0005377_hearing/vestibular/ear_phenot	1.60999567
29	MP0003880_abnormal_central_pattern	1.58726392
30	MP0006276_abnormal_autonomic_nervous	1.58448241
31	MP0002736_abnormal_nociception_after	1.58001621
32	MP0004885_abnormal_endolymph	1.57770263
33	MP0001986_abnormal_taste_sensitivity	1.54487823
34	MP0000569_abnormal_digit_pigmentation	1.54333083
35	MP0002272_abnormal_nervous_system	1.51199719
36	MP0005389_reproductive_system_phenotype	1.47813872
37	MP0002938_white_spotting	1.47311343
38	MP0002132_abnormal_respiratory_system	1.46681462
39	MP0003646_muscle_fatigue	1.42546312
40	MP0004147_increased_porphyrin_level	1.41281833
41	MP0002735_abnormal_chemical_nociception	1.40629392
42	MP0003011_delayed_dark_adaptation	1.39593381
43	MP0003698_abnormal_male_reproductive	1.36024948
44	MP0000372_irregular_coat_pigmentation	1.35293490
45	MP0000631_abnormal_neuroendocrine_gland	1.33604961
46	MP0001486_abnormal_startle_reflex	1.31099940
47	MP0000427_abnormal_hair_cycle	1.28336601
48	MP0001929_abnormal_gametogenesis	1.27616011
49	MP0003718_maternal_effect	1.27409005
50	MP0005645_abnormal_hypothalamus_physiol	1.25472950
51	MP0001529_abnormal_vocalization	1.24865580
52	MP0002837_dystrophic_cardiac_calcinosis	1.24571650
53	MP0002163_abnormal_gland_morphology	1.24154360
54	MP0005084_abnormal_gallbladder_morpholo	1.23391168
55	MP0002557_abnormal_social/conspecific_i	1.23232939
56	MP0002572_abnormal_emotion/affect_behav	1.22983896
57	MP0005423_abnormal_somatic_nervous	1.22479310
58	MP0005394_taste/olfaction_phenotype	1.20142734
59	MP0005499_abnormal_olfactory_system	1.20142734
60	MP0001970_abnormal_pain_threshold	1.19263380
61	MP0002734_abnormal_mechanical_nocicepti	1.18915090
62	MP0000383_abnormal_hair_follicle	1.17500156
63	MP0003787_abnormal_imprinting	1.17160474
64	MP0002909_abnormal_adrenal_gland	1.16847123
65	MP0005379_endocrine/exocrine_gland_phen	1.15051294
66	MP0001905_abnormal_dopamine_level	1.14751632
67	MP0002822_catalepsy	1.14148057
68	MP0000566_synostosis	1.14032472
69	MP0004019_abnormal_vitamin_homeostasis	1.12344559
70	MP0005195_abnormal_posterior_eye	1.11106243
71	MP0002928_abnormal_bile_duct	1.10026163
72	MP0000026_abnormal_inner_ear	1.08918953
73	MP0009780_abnormal_chondrocyte_physiolo	1.08771880
74	MP0002064_seizures	1.08639666
75	MP0001919_abnormal_reproductive_system	1.07666925
76	MP0004742_abnormal_vestibular_system	1.07600579
77	MP0002067_abnormal_sensory_capabilities	1.02706858
78	MP0003806_abnormal_nucleotide_metabolis	1.00761896
79	MP0002733_abnormal_thermal_nociception	0.99490960
80	MP0002210_abnormal_sex_determination	0.97600567
81	MP0001293_anophthalmia	0.92335690
82	MP0000049_abnormal_middle_ear	0.91394247
83	MP0002752_abnormal_somatic_nervous	0.91037705
84	MP0005083_abnormal_biliary_tract	0.90384137
85	MP0001324_abnormal_eye_pigmentation	0.89954110
86	MP0004145_abnormal_muscle_electrophysio	0.89310115
87	MP0005174_abnormal_tail_pigmentation	0.87818763
88	MP0001765_abnormal_ion_homeostasis	0.87175487
89	MP0008058_abnormal_DNA_repair	0.86738512
90	MP0001502_abnormal_circadian_rhythm	0.86091993
91	MP0008995_early_reproductive_senescence	0.85692747
92	MP0010386_abnormal_urinary_bladder	0.84416483
93	MP0001963_abnormal_hearing_physiology	0.83975316
94	MP0002229_neurodegeneration	0.83714961
95	MP0006036_abnormal_mitochondrial_physio	0.83544794
96	MP0002282_abnormal_trachea_morphology	0.83264669
97	MP0002063_abnormal_learning/memory/cond	0.82180144
98	MP0001501_abnormal_sleep_pattern	0.81515275
99	MP0000653_abnormal_sex_gland	0.79256258
100	MP0003283_abnormal_digestive_organ	0.78260685

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormal respiratory motile cilium morphology (HP:0005938)	6.87809415
2	Abnormal respiratory epithelium morphology (HP:0012253)	6.87809415
3	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	6.87081397
4	Dynein arm defect of respiratory motile cilia (HP:0012255)	6.81471608
5	Absent/shortened dynein arms (HP:0200106)	6.81471608
6	Abnormal ciliary motility (HP:0012262)	6.52003881
7	Abnormal respiratory motile cilium physiology (HP:0012261)	6.49158399
8	Rhinitis (HP:0012384)	5.77879696
9	Pancreatic fibrosis (HP:0100732)	4.80893187
10	Pancreatic cysts (HP:0001737)	4.77856184
11	True hermaphroditism (HP:0010459)	4.69165108
12	Abnormality of midbrain morphology (HP:0002418)	4.61331859
13	Molar tooth sign on MRI (HP:0002419)	4.61331859
14	Chronic bronchitis (HP:0004469)	4.42902605
15	Nephronophthisis (HP:0000090)	4.28909718
16	Bronchiectasis (HP:0002110)	4.06849176
17	Abnormality of the renal medulla (HP:0100957)	3.53337835
18	Cystic liver disease (HP:0006706)	3.47360097
19	Chronic hepatic failure (HP:0100626)	3.38050222
20	Medial flaring of the eyebrow (HP:0010747)	3.25962169
21	Occipital encephalocele (HP:0002085)	3.15498665
22	Congenital stationary night blindness (HP:0007642)	2.90767340
23	Nasal polyposis (HP:0100582)	2.84686099
24	Sclerocornea (HP:0000647)	2.82594112
25	Tubular atrophy (HP:0000092)	2.82428763
26	Abnormality of the renal cortex (HP:0011035)	2.77007585
27	Anencephaly (HP:0002323)	2.74990675
28	Gait imbalance (HP:0002141)	2.72842503
29	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.69502364
30	Postaxial foot polydactyly (HP:0001830)	2.65639872
31	Congenital primary aphakia (HP:0007707)	2.65117995
32	Congenital hepatic fibrosis (HP:0002612)	2.61141225
33	Male pseudohermaphroditism (HP:0000037)	2.58709667
34	Chronic sinusitis (HP:0011109)	2.58088742
35	Furrowed tongue (HP:0000221)	2.52610189
36	Infertility (HP:0000789)	2.48005696
37	Nephrogenic diabetes insipidus (HP:0009806)	2.47623393
38	Abnormal drinking behavior (HP:0030082)	2.42059042
39	Polydipsia (HP:0001959)	2.42059042
40	Type II lissencephaly (HP:0007260)	2.33752636
41	Decreased circulating renin level (HP:0003351)	2.28566955
42	Attenuation of retinal blood vessels (HP:0007843)	2.24980672
43	Abnormal rod and cone electroretinograms (HP:0008323)	2.24329361
44	Bronchitis (HP:0012387)	2.20573990
45	Decreased central vision (HP:0007663)	2.20362884
46	Acute necrotizing encephalopathy (HP:0006965)	2.16647592
47	Abolished electroretinogram (ERG) (HP:0000550)	2.09895294
48	Abnormality of the nasal mucosa (HP:0000433)	2.07601915
49	Mitochondrial inheritance (HP:0001427)	2.07281661
50	Genital tract atresia (HP:0001827)	2.06707115
51	Recurrent sinusitis (HP:0011108)	2.05547690
52	Tubulointerstitial nephritis (HP:0001970)	2.05361373
53	Postaxial hand polydactyly (HP:0001162)	2.02327727
54	Vaginal atresia (HP:0000148)	2.00770358
55	Concave nail (HP:0001598)	1.99467679
56	Preaxial hand polydactyly (HP:0001177)	1.95941858
57	Bony spicule pigmentary retinopathy (HP:0007737)	1.95886649
58	Hyperventilation (HP:0002883)	1.95730535
59	Large for gestational age (HP:0001520)	1.91912800
60	Increased CSF lactate (HP:0002490)	1.91618263
61	Polyuria (HP:0000103)	1.90368364
62	Acute encephalopathy (HP:0006846)	1.89202546
63	Poor coordination (HP:0002370)	1.88961626
64	Congenital, generalized hypertrichosis (HP:0004540)	1.88779265
65	Pendular nystagmus (HP:0012043)	1.88310046
66	Abnormal mitochondria in muscle tissue (HP:0008316)	1.86868394
67	Oculomotor apraxia (HP:0000657)	1.86821273
68	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.83583661
69	Bile duct proliferation (HP:0001408)	1.82106636
70	Abnormal biliary tract physiology (HP:0012439)	1.82106636
71	Abnormality of macular pigmentation (HP:0008002)	1.82068422
72	Progressive macrocephaly (HP:0004481)	1.81808482
73	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.77590324
74	Lipid accumulation in hepatocytes (HP:0006561)	1.75564856
75	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.74724499
76	Abnormality of alanine metabolism (HP:0010916)	1.74724499
77	Hyperalaninemia (HP:0003348)	1.74724499
78	Asplenia (HP:0001746)	1.69570452
79	Increased hepatocellular lipid droplets (HP:0006565)	1.68667922
80	Lissencephaly (HP:0001339)	1.67524261
81	Optic disc pallor (HP:0000543)	1.67006073
82	3-Methylglutaconic aciduria (HP:0003535)	1.65133769
83	Methylmalonic acidemia (HP:0002912)	1.62531915
84	Abnormality of the pons (HP:0007361)	1.61760620
85	Aganglionic megacolon (HP:0002251)	1.61194082
86	Progressive cerebellar ataxia (HP:0002073)	1.60844894
87	Retinitis pigmentosa (HP:0000510)	1.58668582
88	Hypoplasia of the pons (HP:0012110)	1.56748718
89	Stage 5 chronic kidney disease (HP:0003774)	1.56247313
90	Renal cortical cysts (HP:0000803)	1.55879170
91	Multicystic kidney dysplasia (HP:0000003)	1.55381818
92	Broad-based gait (HP:0002136)	1.53496223
93	Abnormality of renal excretion (HP:0011036)	1.53181967
94	Hepatocellular necrosis (HP:0001404)	1.52710361
95	Tubulointerstitial abnormality (HP:0001969)	1.52658197
96	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.51939961
97	Hyperactive renin-angiotensin system (HP:0000841)	1.51849067
98	Cerebellar dysplasia (HP:0007033)	1.51717109
99	Hypothermia (HP:0002045)	1.51637778
100	Abnormal urine output (HP:0012590)	1.51065781

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAPK15	4.71126965
2	FRK	4.10471844
3	TLK1	3.47655813
4	ADRBK2	3.04066793
5	BMPR1B	2.93874100
6	WNK4	2.77316553
7	ZAK	2.58002395
8	MAP4K2	2.45696686
9	MST4	2.35896599
10	GRK1	2.30973685
11	WNK3	2.28159906
12	PINK1	2.20991047
13	PNCK	2.15297432
14	ACVR1B	1.97671792
15	NUAK1	1.96292730
16	INSRR	1.76412892
17	STK16	1.73524396
18	MAPK13	1.68869149
19	NME1	1.64850677
20	MAP3K4	1.58351318
21	TAOK3	1.54718246
22	CASK	1.51654465
23	STK39	1.49278576
24	MAPKAPK3	1.46841540
25	PLK4	1.44943080
26	OXSR1	1.42028871
27	VRK1	1.22777567
28	VRK2	1.17883179
29	DYRK2	1.11749190
30	PTK2B	1.09353417
31	ADRBK1	1.06174088
32	BRSK2	1.05321061
33	PHKG1	1.03332850
34	PHKG2	1.03332850
35	PAK3	0.96970926
36	PRKCG	0.95427198
37	MARK1	0.94981582
38	MKNK2	0.94829922
39	MAP2K7	0.91558192
40	PRKCI	0.88815673
41	TXK	0.85076380
42	TNIK	0.76912049
43	TGFBR1	0.76451246
44	PRKCE	0.76295595
45	BCR	0.75461069
46	DAPK2	0.74427601
47	PLK2	0.74085159
48	TRIM28	0.73145480
49	CAMKK2	0.72525384
50	WEE1	0.70547557
51	TAF1	0.69270852
52	ERBB3	0.68344466
53	MUSK	0.64489444
54	TSSK6	0.63865247
55	MAP2K6	0.63237400
56	IRAK1	0.62647450
57	SIK2	0.60433767
58	CSNK1G2	0.60399716
59	RPS6KA5	0.58509998
60	BCKDK	0.58492727
61	MAPKAPK5	0.57634057
62	PRKCQ	0.56762919
63	STK38L	0.56619602
64	ERBB2	0.53354777
65	AKT3	0.50170652
66	PLK1	0.49997214
67	CCNB1	0.49970578
68	PRKACA	0.48121811
69	CSNK1G3	0.47939923
70	PKN1	0.47271939
71	CAMK2A	0.46410945
72	CSNK1G1	0.46118271
73	EPHA2	0.45240522
74	TIE1	0.45180907
75	NEK2	0.44302960
76	PLK3	0.43738299
77	MAP3K12	0.41725024
78	CHEK2	0.41310943
79	CDK8	0.41189178
80	NTRK3	0.40875443
81	STK11	0.40588640
82	MAP2K4	0.40221249
83	PRKCZ	0.39093734
84	CAMK1	0.38193248
85	WNK1	0.37882763
86	CHUK	0.36597149
87	PRKG1	0.36090577
88	CSNK1A1	0.35799776
89	PRKCA	0.34754063
90	NTRK2	0.33906816
91	IKBKB	0.33692590
92	PIK3CA	0.33650665
93	PRKAA1	0.32520507
94	ATR	0.31732193
95	CSNK1A1L	0.30531145
96	MKNK1	0.27085549
97	STK3	0.26761548
98	TEC	0.26360292
99	MAP3K7	0.23955122
100	CSNK1D	0.23953923

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	3.05844676
2	Huntingtons disease_Homo sapiens_hsa05016	2.43916291
3	Phototransduction_Homo sapiens_hsa04744	2.43372959
4	Linoleic acid metabolism_Homo sapiens_hsa00591	2.33864156
5	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.30176937
6	Parkinsons disease_Homo sapiens_hsa05012	2.29859680
7	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.28680970
8	Chemical carcinogenesis_Homo sapiens_hsa05204	2.16412761
9	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.12545066
10	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	2.11866836
11	Protein export_Homo sapiens_hsa03060	2.04494211
12	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.95158294
13	Basal transcription factors_Homo sapiens_hsa03022	1.94623530
14	Nicotine addiction_Homo sapiens_hsa05033	1.93099853
15	Nitrogen metabolism_Homo sapiens_hsa00910	1.88390426
16	Butanoate metabolism_Homo sapiens_hsa00650	1.86706531
17	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.82168649
18	Caffeine metabolism_Homo sapiens_hsa00232	1.79572947
19	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.77975480
20	Homologous recombination_Homo sapiens_hsa03440	1.75770789
21	Selenocompound metabolism_Homo sapiens_hsa00450	1.73715833
22	RNA polymerase_Homo sapiens_hsa03020	1.73315392
23	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.65963943
24	Fanconi anemia pathway_Homo sapiens_hsa03460	1.65259813
25	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.62975493
26	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.60850210
27	Alzheimers disease_Homo sapiens_hsa05010	1.56566210
28	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.56334491
29	Histidine metabolism_Homo sapiens_hsa00340	1.56123421
30	Ribosome_Homo sapiens_hsa03010	1.55207671
31	Cardiac muscle contraction_Homo sapiens_hsa04260	1.46324426
32	Tryptophan metabolism_Homo sapiens_hsa00380	1.41994792
33	beta-Alanine metabolism_Homo sapiens_hsa00410	1.39050866
34	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.38256602
35	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.34586551
36	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.34383508
37	Retinol metabolism_Homo sapiens_hsa00830	1.33907343
38	Peroxisome_Homo sapiens_hsa04146	1.31669158
39	Olfactory transduction_Homo sapiens_hsa04740	1.28565738
40	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.25106955
41	Collecting duct acid secretion_Homo sapiens_hsa04966	1.23353375
42	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.22700800
43	Ether lipid metabolism_Homo sapiens_hsa00565	1.20979549
44	Taste transduction_Homo sapiens_hsa04742	1.17391787
45	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.09256362
46	Regulation of autophagy_Homo sapiens_hsa04140	1.08874785
47	RNA degradation_Homo sapiens_hsa03018	1.06863658
48	Tyrosine metabolism_Homo sapiens_hsa00350	1.05959566
49	ABC transporters_Homo sapiens_hsa02010	1.04071920
50	Nucleotide excision repair_Homo sapiens_hsa03420	1.03454825
51	Propanoate metabolism_Homo sapiens_hsa00640	1.00754942
52	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.00286884
53	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.98759172
54	Proteasome_Homo sapiens_hsa03050	0.90226350
55	Purine metabolism_Homo sapiens_hsa00230	0.88630676
56	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.87432719
57	Morphine addiction_Homo sapiens_hsa05032	0.84337162
58	Glutathione metabolism_Homo sapiens_hsa00480	0.83863690
59	Phenylalanine metabolism_Homo sapiens_hsa00360	0.83261231
60	One carbon pool by folate_Homo sapiens_hsa00670	0.82741489
61	Sulfur relay system_Homo sapiens_hsa04122	0.82224671
62	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.76826387
63	Metabolic pathways_Homo sapiens_hsa01100	0.75403631
64	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.74883926
65	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.71622870
66	Serotonergic synapse_Homo sapiens_hsa04726	0.71412069
67	Pyrimidine metabolism_Homo sapiens_hsa00240	0.69999653
68	Fatty acid degradation_Homo sapiens_hsa00071	0.69627506
69	Insulin secretion_Homo sapiens_hsa04911	0.69405359
70	Steroid biosynthesis_Homo sapiens_hsa00100	0.67469358
71	Sulfur metabolism_Homo sapiens_hsa00920	0.66190129
72	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.64656312
73	Circadian rhythm_Homo sapiens_hsa04710	0.64546227
74	Glutamatergic synapse_Homo sapiens_hsa04724	0.64079386
75	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.63126089
76	Circadian entrainment_Homo sapiens_hsa04713	0.59912423
77	Salivary secretion_Homo sapiens_hsa04970	0.59850683
78	GABAergic synapse_Homo sapiens_hsa04727	0.59609632
79	Mismatch repair_Homo sapiens_hsa03430	0.52927226
80	Glycerolipid metabolism_Homo sapiens_hsa00561	0.52916603
81	Mineral absorption_Homo sapiens_hsa04978	0.52480401
82	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.52320989
83	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.52260215
84	Calcium signaling pathway_Homo sapiens_hsa04020	0.49310619
85	Folate biosynthesis_Homo sapiens_hsa00790	0.44906962
86	Cocaine addiction_Homo sapiens_hsa05030	0.44528209
87	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.40211132
88	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.39698345
89	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.39306713
90	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.35839640
91	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.34487687
92	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.34294838
93	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.33038780
94	Non-homologous end-joining_Homo sapiens_hsa03450	0.32304687
95	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.32068138
96	Fat digestion and absorption_Homo sapiens_hsa04975	0.29972816
97	Dopaminergic synapse_Homo sapiens_hsa04728	0.28618904
98	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.28147988
99	Base excision repair_Homo sapiens_hsa03410	0.27726236
100	Amphetamine addiction_Homo sapiens_hsa05031	0.27510669

LRTOMT

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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