LRWD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene interacts with components of the origin recognition complex (ORC) and regulates the formation of the prereplicative complex. The encoded protein stabilizes the ORC and therefore aids in DNA replication. This protein is required for the G1/S phase transition of the cell cycle. In addition, the encoded protein binds to trimethylated histone H3 in heterochromatin and recruits the ORC and lysine methyltransferases, which help maintain the repressive heterochromatic state. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)5.06576157
2peptidyl-arginine omega-N-methylation (GO:0035247)4.65669973
3viral transcription (GO:0019083)4.57457679
4proline biosynthetic process (GO:0006561)4.51760288
5DNA deamination (GO:0045006)4.45969772
6maturation of SSU-rRNA (GO:0030490)4.45474332
7translational termination (GO:0006415)4.44308341
8DNA strand elongation involved in DNA replication (GO:0006271)4.41904705
9GDP-mannose metabolic process (GO:0019673)4.26715191
10protein insertion into membrane (GO:0051205)4.26132595
11telomere maintenance via semi-conservative replication (GO:0032201)4.25666264
12DNA strand elongation (GO:0022616)4.23686400
13translational elongation (GO:0006414)4.02884248
14ribosomal small subunit biogenesis (GO:0042274)3.99955611
15* DNA replication initiation (GO:0006270)3.95768327
16peptidyl-arginine N-methylation (GO:0035246)3.91082030
17peptidyl-arginine methylation (GO:0018216)3.91082030
18ribosomal large subunit biogenesis (GO:0042273)3.90356372
19DNA unwinding involved in DNA replication (GO:0006268)3.87914306
20positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.87525646
21DNA replication checkpoint (GO:0000076)3.77208007
22regulation of chromatin binding (GO:0035561)3.74904022
23telomere maintenance via recombination (GO:0000722)3.73994415
24nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.73482366
25SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.69698057
26translational initiation (GO:0006413)3.69594844
27snRNA metabolic process (GO:0016073)3.65143649
28DNA replication-dependent nucleosome assembly (GO:0006335)3.63203238
29DNA replication-dependent nucleosome organization (GO:0034723)3.63203238
30motile cilium assembly (GO:0044458)3.63045256
31negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.58539633
32cotranslational protein targeting to membrane (GO:0006613)3.58469117
33protein targeting to ER (GO:0045047)3.57886353
34negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.57799238
35histone arginine methylation (GO:0034969)3.57425741
36cellular protein complex disassembly (GO:0043624)3.55899595
37intracellular estrogen receptor signaling pathway (GO:0030520)3.54688227
38mitotic recombination (GO:0006312)3.52011444
39chromatin remodeling at centromere (GO:0031055)3.49581224
40sperm-egg recognition (GO:0035036)3.49186435
41cilium or flagellum-dependent cell motility (GO:0001539)3.47472482
42binding of sperm to zona pellucida (GO:0007339)3.47225702
43negative regulation of DNA-templated transcription, elongation (GO:0032785)3.46435786
44protein localization to chromosome, centromeric region (GO:0071459)3.46312009
45viral life cycle (GO:0019058)3.44908663
46negative regulation of cell size (GO:0045792)3.42718404
47cilium movement (GO:0003341)3.42276883
48telomere maintenance via telomere lengthening (GO:0010833)3.40592059
49establishment of protein localization to endoplasmic reticulum (GO:0072599)3.38230170
50nucleotide-excision repair, DNA gap filling (GO:0006297)3.37862151
51CENP-A containing nucleosome assembly (GO:0034080)3.37333755
52protein complex disassembly (GO:0043241)3.37195804
53protein localization to endoplasmic reticulum (GO:0070972)3.34952278
54formation of translation preinitiation complex (GO:0001731)3.34638846
55spliceosomal tri-snRNP complex assembly (GO:0000244)3.32889907
56ribonucleoprotein complex biogenesis (GO:0022613)3.31124537
57fusion of sperm to egg plasma membrane (GO:0007342)3.29807414
58tolerance induction (GO:0002507)3.29173352
59axonemal dynein complex assembly (GO:0070286)3.28294019
60histone exchange (GO:0043486)3.25187339
61apoptotic process involved in morphogenesis (GO:0060561)3.25095739
62mitotic nuclear envelope disassembly (GO:0007077)3.23716104
63DNA replication-independent nucleosome organization (GO:0034724)3.22785613
64DNA replication-independent nucleosome assembly (GO:0006336)3.22785613
65negative regulation of B cell apoptotic process (GO:0002903)3.22671943
66intra-S DNA damage checkpoint (GO:0031573)3.21102964
67snRNA processing (GO:0016180)3.20963410
68chaperone mediated protein folding requiring cofactor (GO:0051085)3.19372304
69protein localization to kinetochore (GO:0034501)3.17328851
70macromolecular complex disassembly (GO:0032984)3.17273920
71microtubule depolymerization (GO:0007019)3.16818903
72regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.15317478
73IMP biosynthetic process (GO:0006188)3.14016701
74regulation of mammary gland epithelial cell proliferation (GO:0033599)3.12745946
75cell-cell recognition (GO:0009988)3.12707307
76rRNA processing (GO:0006364)3.12577145
77spliceosomal snRNP assembly (GO:0000387)3.10186164
78nuclear pore complex assembly (GO:0051292)3.09319498
79kinetochore organization (GO:0051383)3.08764963
80left/right pattern formation (GO:0060972)3.06429693
81rRNA metabolic process (GO:0016072)3.06289383
82nucleobase biosynthetic process (GO:0046112)3.06062830
83translesion synthesis (GO:0019985)3.04486396
84NIK/NF-kappaB signaling (GO:0038061)3.04267421
85nuclear pore organization (GO:0006999)3.03818144
86modulation by virus of host process (GO:0019054)3.02890978
87nuclear-transcribed mRNA catabolic process (GO:0000956)3.02623754
88gonadal mesoderm development (GO:0007506)3.02130610
89protein-DNA complex disassembly (GO:0032986)3.01632367
90nucleosome disassembly (GO:0006337)3.01632367
91mitotic sister chromatid segregation (GO:0000070)3.01161514
92regulation of translational termination (GO:0006449)3.01154072
93piRNA metabolic process (GO:0034587)3.00435682
94regulation of histone H3-K9 methylation (GO:0051570)2.96148909
95membrane disassembly (GO:0030397)2.92780318
96nuclear envelope disassembly (GO:0051081)2.92780318
97pseudouridine synthesis (GO:0001522)2.92773339
98histone H2A acetylation (GO:0043968)2.91920252
99regulation of interferon-beta biosynthetic process (GO:0045357)2.91361624
100UV protection (GO:0009650)2.90242604
101amyloid precursor protein catabolic process (GO:0042987)2.89801860
102RNA catabolic process (GO:0006401)2.89356137
103UTP biosynthetic process (GO:0006228)2.89164401
104ribosome biogenesis (GO:0042254)2.89057744
105mRNA catabolic process (GO:0006402)2.88794100
106chromosome condensation (GO:0030261)2.88738839
107DNA duplex unwinding (GO:0032508)2.87130762
108mitotic metaphase plate congression (GO:0007080)2.86003271
109DNA packaging (GO:0006323)2.85549196
110DNA geometric change (GO:0032392)2.85138415
111proline metabolic process (GO:0006560)2.84176156
112sperm motility (GO:0030317)2.83326029
113mannose metabolic process (GO:0006013)2.82838422
114pentose metabolic process (GO:0019321)2.82679856
115base-excision repair, AP site formation (GO:0006285)2.82138579
116termination of RNA polymerase II transcription (GO:0006369)2.82002203
117cellular response to virus (GO:0098586)2.81613714
118meiotic chromosome segregation (GO:0045132)2.81070048
119kinetochore assembly (GO:0051382)2.81001178
120DNA conformation change (GO:0071103)2.80953167
121positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.80513306
122epithelial cilium movement (GO:0003351)2.80079647
123cell wall macromolecule metabolic process (GO:0044036)2.79995022
124cell wall macromolecule catabolic process (GO:0016998)2.79995022
125transcription-coupled nucleotide-excision repair (GO:0006283)2.79968420
126mitotic nuclear envelope reassembly (GO:0007084)2.79363319
127nuclear envelope reassembly (GO:0031468)2.79363319
128rRNA transcription (GO:0009303)2.79073054
129regulation of type I interferon-mediated signaling pathway (GO:0060338)2.78819746
130translation (GO:0006412)2.78484079
131tRNA methylation (GO:0030488)2.78436562
132establishment of integrated proviral latency (GO:0075713)2.78402268
133negative regulation of viral release from host cell (GO:1902187)2.78298021
134activation of Rac GTPase activity (GO:0032863)2.78243430
135chromatin assembly or disassembly (GO:0006333)2.77116262
136purine nucleobase biosynthetic process (GO:0009113)2.76450614
137metallo-sulfur cluster assembly (GO:0031163)2.76295260
138iron-sulfur cluster assembly (GO:0016226)2.76295260
139telomere maintenance (GO:0000723)2.75791143
140mismatch repair (GO:0006298)2.74932699
141telomere organization (GO:0032200)2.74886316
142COPI coating of Golgi vesicle (GO:0048205)2.74871782
143Golgi transport vesicle coating (GO:0048200)2.74871782
144spliceosomal complex assembly (GO:0000245)2.74553424
145synaptonemal complex assembly (GO:0007130)2.72747201
146spermatid development (GO:0007286)2.72534771
147negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.71610108
148mitotic sister chromatid cohesion (GO:0007064)2.71525198
149male meiosis (GO:0007140)2.71258966
150peptidyl-arginine modification (GO:0018195)2.71251386
151IMP metabolic process (GO:0046040)2.70759891
152establishment of apical/basal cell polarity (GO:0035089)2.70717632
153heterochromatin organization (GO:0070828)2.70601486
154ATP-dependent chromatin remodeling (GO:0043044)2.70136722
155positive regulation of protein homooligomerization (GO:0032464)2.69430394
156negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.63661399
157retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.63521233
158folic acid metabolic process (GO:0046655)2.62791552
159negative regulation of toll-like receptor signaling pathway (GO:0034122)2.61291716
1603-UTR-mediated mRNA stabilization (GO:0070935)2.59885581
161guanosine-containing compound biosynthetic process (GO:1901070)2.58106930
162positive thymic T cell selection (GO:0045059)2.57332059
163tRNA modification (GO:0006400)2.55165169
164positive regulation by symbiont of host defense response (GO:0052509)2.54990141
165modulation by symbiont of host defense response (GO:0052031)2.54990141
166modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.54990141
167modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.54990141
168positive regulation by organism of defense response of other organism involved in symbiotic interact2.54990141
169modulation by symbiont of host immune response (GO:0052553)2.54990141
170mitochondrial fusion (GO:0008053)2.54059967
171pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.52224255
172modulation by symbiont of host cellular process (GO:0044068)2.51608931
173vitamin transmembrane transport (GO:0035461)2.47794641
174response to peptidoglycan (GO:0032494)2.47329282
175negative regulation of response to biotic stimulus (GO:0002832)2.41296148
176regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 2.41242544
177positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.41122973
178pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.40639923
179misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.40417820
180pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.39188257
181antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.37547222
182pentose-phosphate shunt (GO:0006098)2.37169434
183chromatin assembly (GO:0031497)2.36311712
184virion assembly (GO:0019068)2.36137117
185negative regulation of tumor necrosis factor production (GO:0032720)2.34715072
186mitotic G1/S transition checkpoint (GO:0044819)2.34633979
187leukocyte aggregation (GO:0070486)2.34280171
188positive regulation of release of cytochrome c from mitochondria (GO:0090200)2.33619886
189membrane protein intracellular domain proteolysis (GO:0031293)2.33255578
190mitotic G1 DNA damage checkpoint (GO:0031571)2.33227870
191thymic T cell selection (GO:0045061)2.32681552

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.31649162
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.24649110
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.83551674
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.82233965
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.62294902
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.48250316
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.15533006
8MYC_19079543_ChIP-ChIP_MESCs_Mouse2.71886617
9MYC_18358816_ChIP-ChIP_MESCs_Mouse2.71332559
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.67477891
11* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.61574729
12LXR_22292898_ChIP-Seq_THP-1_Human2.60085402
13KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.58147374
14MYC_19030024_ChIP-ChIP_MESCs_Mouse2.56675575
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.56640206
16GABP_17652178_ChIP-ChIP_JURKAT_Human2.47262385
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.39037256
18ELF1_17652178_ChIP-ChIP_JURKAT_Human2.30341360
19NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.28634199
20P68_20966046_ChIP-Seq_HELA_Human2.27099791
21XRN2_22483619_ChIP-Seq_HELA_Human2.25262328
22SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.21723484
23VDR_23849224_ChIP-Seq_CD4+_Human2.19464870
24CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.18242306
25CREB1_15753290_ChIP-ChIP_HEK293T_Human2.12321644
26FOXP3_21729870_ChIP-Seq_TREG_Human2.05676607
27SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.01092075
28KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.00532459
29ELK3_25401928_ChIP-Seq_HUVEC_Human2.00223201
30CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.95143070
31NELFA_20434984_ChIP-Seq_ESCs_Mouse1.93162974
32TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.92012289
33KDM2B_26808549_Chip-Seq_SUP-B15_Human1.91444265
34ELF1_20517297_ChIP-Seq_JURKAT_Human1.89844810
35TET1_21451524_ChIP-Seq_MESCs_Mouse1.88488142
36DCP1A_22483619_ChIP-Seq_HELA_Human1.87666586
37MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.86688952
38RACK7_27058665_Chip-Seq_MCF-7_Human1.84904304
39E2F1_21310950_ChIP-Seq_MCF-7_Human1.83612075
40CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.81867230
41TTF2_22483619_ChIP-Seq_HELA_Human1.79405756
42MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.78542122
43CIITA_25753668_ChIP-Seq_RAJI_Human1.76937282
44BCL6_27268052_Chip-Seq_Bcells_Human1.76487666
45GABP_19822575_ChIP-Seq_HepG2_Human1.76189458
46BCOR_27268052_Chip-Seq_Bcells_Human1.73828610
47MYC_22102868_ChIP-Seq_BL_Human1.73258613
48* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.70527934
49KDM2B_26808549_Chip-Seq_DND41_Human1.70521743
50MYCN_18555785_ChIP-Seq_MESCs_Mouse1.70281305
51FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.70203557
52E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.67957229
53EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.66122763
54THAP11_20581084_ChIP-Seq_MESCs_Mouse1.66048257
55YY1_21170310_ChIP-Seq_MESCs_Mouse1.65831503
56E2F1_18555785_ChIP-Seq_MESCs_Mouse1.60622206
57PHF8_20622854_ChIP-Seq_HELA_Human1.59423670
58ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.59083284
59SA1_27219007_Chip-Seq_ERYTHROID_Human1.58501195
60POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.58193977
61STAT6_21828071_ChIP-Seq_BEAS2B_Human1.57106545
62* SMC4_20622854_ChIP-Seq_HELA_Human1.56528969
63CTCF_27219007_Chip-Seq_ERYTHROID_Human1.55937756
64TCF7_22412390_ChIP-Seq_EML_Mouse1.55811490
65SRY_22984422_ChIP-ChIP_TESTIS_Rat1.55458795
66SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.54430815
67VDR_24763502_ChIP-Seq_THP-1_Human1.48352788
68THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.47372658
69* E2F1_20622854_ChIP-Seq_HELA_Human1.47099355
70FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.45726694
71NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.44896674
72HOXB4_20404135_ChIP-ChIP_EML_Mouse1.43795948
73SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.43230794
74ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.42810166
75VDR_21846776_ChIP-Seq_THP-1_Human1.41677327
76AR_21909140_ChIP-Seq_LNCAP_Human1.41133696
77NANOG_18555785_ChIP-Seq_MESCs_Mouse1.40386101
78NOTCH1_21737748_ChIP-Seq_TLL_Human1.39823945
79RARG_19884340_ChIP-ChIP_MEFs_Mouse1.39226313
80SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.39218416
81PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.38519291
82* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.37795159
83PU.1_20513432_ChIP-Seq_Bcells_Mouse1.33209969
84YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.32810605
85RARA_24833708_ChIP-Seq_LIVER_Mouse1.31287818
86EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.30817358
87ZFX_18555785_ChIP-Seq_MESCs_Mouse1.29954341
88SRF_21415370_ChIP-Seq_HL-1_Mouse1.29922623
89ELK1_19687146_ChIP-ChIP_HELA_Human1.29889557
90EGR1_19374776_ChIP-ChIP_THP-1_Human1.29876768
91CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.29313603
92RARB_24833708_ChIP-Seq_LIVER_Mouse1.29203016
93CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.29161517
94KDM5A_27292631_Chip-Seq_BREAST_Human1.28871497
95* FOXP1_21924763_ChIP-Seq_HESCs_Human1.28210789
96TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.27382760
97CTCF_26484167_Chip-Seq_Bcells_Mouse1.26815543
98* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.26308698
99KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.26080833
100CTCF_21964334_Chip-Seq_Bcells_Human1.25662235
101TP53_22127205_ChIP-Seq_IMR90_Human1.25332860
102PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.24549406
103SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.24433904
104NCOR1_26117541_ChIP-Seq_K562_Human1.23227196
105CREB1_26743006_Chip-Seq_LNCaP_Human1.20222401
106TP63_19390658_ChIP-ChIP_HaCaT_Human1.19553184
107CTCF_20526341_ChIP-Seq_ESCs_Human1.18652373
108UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.18280303
109SCL_19346495_ChIP-Seq_HPC-7_Human1.17629400
110KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.17194225
111EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.16114515
112MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.14938634
113CTCF_21964334_ChIP-Seq_BJAB-B_Human1.14697868
114DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.14588109
115MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.14525329
116ETS1_21867929_ChIP-Seq_TH2_Mouse1.13888530
117E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.13833844
118SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.13285411
119SPI1_23547873_ChIP-Seq_NB4_Human1.12981227
120CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.12795914
121KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.12680281
122SA1_27219007_Chip-Seq_Bcells_Human1.11204513
123SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.10640274
124CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.10063576
125KDM2B_26808549_Chip-Seq_JURKAT_Human1.09915654
126RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.09635890
127KDM2B_26808549_Chip-Seq_K562_Human1.09471436
128SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.08796488
129CTCF_27219007_Chip-Seq_Bcells_Human1.08125324
130DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.08111859
131IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.06215136
132SOX2_18555785_ChIP-Seq_MESCs_Mouse1.05902567
133RBPJ_22232070_ChIP-Seq_NCS_Mouse1.05058519
134GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.03160949
135MYC_18940864_ChIP-ChIP_HL60_Human1.01604801
136KLF4_18555785_ChIP-Seq_MESCs_Mouse0.99701500
137E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.98460059
138TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.98398706
139POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.98164636
140STAT3_1855785_ChIP-Seq_MESCs_Mouse0.96871344
141CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.95109228
142KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.92204580
143PADI4_21655091_ChIP-ChIP_MCF-7_Human0.90404511
144ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.89124036
145UTX_26944678_Chip-Seq_JUKART_Human0.88416464
146BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.87462065
147SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.86790792
148YY1_22570637_ChIP-Seq_MALME-3M_Human0.86784602
149MYB_26560356_Chip-Seq_TH1_Human0.85538684
150CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.85475300
151TFEB_21752829_ChIP-Seq_HELA_Human0.85430206
152RUNX1_22412390_ChIP-Seq_EML_Mouse0.84711557
153MYB_26560356_Chip-Seq_TH2_Human0.84631437
154GATA1_22383799_ChIP-Seq_G1ME_Mouse0.84424856
155CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.84390365
156HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.84137352
157MAF_26560356_Chip-Seq_TH1_Human0.84087601
158MAF_26560356_Chip-Seq_TH2_Human0.82032998

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.32543482
2MP0010094_abnormal_chromosome_stability4.21101435
3MP0003111_abnormal_nucleus_morphology4.06607642
4MP0008057_abnormal_DNA_replication3.96430452
5MP0005410_abnormal_fertilization3.73187522
6MP0003077_abnormal_cell_cycle3.49164160
7MP0008058_abnormal_DNA_repair3.43961259
8MP0004957_abnormal_blastocyst_morpholog3.30152820
9MP0005451_abnormal_body_composition2.98620711
10MP0008877_abnormal_DNA_methylation2.91813736
11MP0003303_peritoneal_inflammation2.90548941
12MP0008007_abnormal_cellular_replicative2.85982450
13MP0002396_abnormal_hematopoietic_system2.82456358
14MP0000678_abnormal_parathyroid_gland2.45854032
15MP0005058_abnormal_lysosome_morphology2.32579271
16MP0001929_abnormal_gametogenesis2.22842406
17MP0008260_abnormal_autophagy2.14873674
18MP0004808_abnormal_hematopoietic_stem2.12644216
19MP0008932_abnormal_embryonic_tissue2.10127588
20MP0005397_hematopoietic_system_phenotyp2.03080884
21MP0001545_abnormal_hematopoietic_system2.03080884
22MP0002210_abnormal_sex_determination2.02844117
23MP0003763_abnormal_thymus_physiology2.00880871
24MP0003786_premature_aging1.99787118
25MP0000490_abnormal_crypts_of1.99223963
26MP0003698_abnormal_male_reproductive1.90705958
27MP0001849_ear_inflammation1.85872156
28MP0000350_abnormal_cell_proliferation1.78273023
29MP0002249_abnormal_larynx_morphology1.74450321
30MP0005171_absent_coat_pigmentation1.73713273
31MP0001145_abnormal_male_reproductive1.70556666
32MP0002132_abnormal_respiratory_system1.62560978
33MP0001730_embryonic_growth_arrest1.62293161
34MP0003172_abnormal_lysosome_physiology1.61553517
35MP0002398_abnormal_bone_marrow1.57096130
36MP0010307_abnormal_tumor_latency1.55621532
37MP0000313_abnormal_cell_death1.52161220
38MP0000703_abnormal_thymus_morphology1.51740446
39MP0005083_abnormal_biliary_tract1.49711477
40MP0005623_abnormal_meninges_morphology1.49576993
41MP0009333_abnormal_splenocyte_physiolog1.48172001
42MP0008875_abnormal_xenobiotic_pharmacok1.45167450
43MP0002877_abnormal_melanocyte_morpholog1.42573336
44MP0004381_abnormal_hair_follicle1.42395749
45MP0004185_abnormal_adipocyte_glucose1.42247479
46MP0002019_abnormal_tumor_incidence1.42201786
47MP0000653_abnormal_sex_gland1.42173373
48MP0005174_abnormal_tail_pigmentation1.41737627
49MP0000750_abnormal_muscle_regeneration1.40375556
50MP0009840_abnormal_foam_cell1.35950107
51MP0002722_abnormal_immune_system1.35685054
52MP0004858_abnormal_nervous_system1.35464616
53MP0000685_abnormal_immune_system1.35323879
54MP0000689_abnormal_spleen_morphology1.32158815
55MP0005075_abnormal_melanosome_morpholog1.30632351
56MP0003453_abnormal_keratinocyte_physiol1.29280148
57MP0003705_abnormal_hypodermis_morpholog1.27630268
58MP0000003_abnormal_adipose_tissue1.27517521
59MP0002160_abnormal_reproductive_system1.27047952
60MP0006292_abnormal_olfactory_placode1.25341122
61MP0002653_abnormal_ependyma_morphology1.22849428
62MP0002080_prenatal_lethality1.20876585
63MP0001697_abnormal_embryo_size1.20706126
64MP0010352_gastrointestinal_tract_polyps1.19299346
65MP0001672_abnormal_embryogenesis/_devel1.19179076
66MP0005380_embryogenesis_phenotype1.19179076
67MP0002429_abnormal_blood_cell1.18900388
68MP0001835_abnormal_antigen_presentation1.18091810
69MP0004947_skin_inflammation1.16424885
70MP0004233_abnormal_muscle_weight1.14249623
71MP0009278_abnormal_bone_marrow1.13397658
72MP0000716_abnormal_immune_system1.13102328
73MP0001661_extended_life_span1.12736320
74MP0002161_abnormal_fertility/fecundity1.11878886
75MP0005671_abnormal_response_to1.11141866
76MP0002085_abnormal_embryonic_tissue1.09971470
77MP0001348_abnormal_lacrimal_gland1.09762795
78MP0002419_abnormal_innate_immunity1.09719298
79MP0008995_early_reproductive_senescence1.08289180
80MP0001800_abnormal_humoral_immune1.08064173
81MP0001293_anophthalmia1.06974018
82MP0000747_muscle_weakness1.06715074
83MP0002405_respiratory_system_inflammati1.05497519
84MP0009379_abnormal_foot_pigmentation1.05318822
85MP0003123_paternal_imprinting1.04352542
86MP0002420_abnormal_adaptive_immunity1.03987725
87MP0002102_abnormal_ear_morphology1.03254379
88MP0003984_embryonic_growth_retardation1.03195486
89MP0005501_abnormal_skin_physiology1.02604801
90MP0001819_abnormal_immune_cell1.02001195
91MP0003315_abnormal_perineum_morphology1.01759339
92MP0002088_abnormal_embryonic_growth/wei1.00083255
93MP0000858_altered_metastatic_potential0.99014216
94MP0006035_abnormal_mitochondrial_morpho0.97228778
95MP0002095_abnormal_skin_pigmentation0.96855024
96MP0000465_gastrointestinal_hemorrhage0.96514965
97MP0002084_abnormal_developmental_patter0.96125483
98MP0002452_abnormal_antigen_presenting0.95183880
99MP0003806_abnormal_nucleotide_metabolis0.93642624
100MP0002089_abnormal_postnatal_growth/wei0.93293945
101MP0002723_abnormal_immune_serum0.92283100
102MP0005423_abnormal_somatic_nervous0.90588764
103MP0002086_abnormal_extraembryonic_tissu0.88252698
104MP0000015_abnormal_ear_pigmentation0.87251569
105MP0005389_reproductive_system_phenotype0.87123507
106MP0001986_abnormal_taste_sensitivity0.86875615
107MP0004197_abnormal_fetal_growth/weight/0.86339119
108MP0005621_abnormal_cell_physiology0.85745085
109MP0000681_abnormal_thyroid_gland0.82290917
110MP0004147_increased_porphyrin_level0.82038562
111MP0001346_abnormal_lacrimal_gland0.81171434
112MP0001853_heart_inflammation0.80506151
113MP0005310_abnormal_salivary_gland0.80387255
114MP0003329_amyloid_beta_deposits0.79609165
115MP0008961_abnormal_basal_metabolism0.78834927
116MP0005384_cellular_phenotype0.77786989
117MP0001873_stomach_inflammation0.76155927
118MP0005025_abnormal_response_to0.75512533
119MP0003718_maternal_effect0.75296495
120MP0005000_abnormal_immune_tolerance0.73557532
121MP0005375_adipose_tissue_phenotype0.73545858
122MP0009785_altered_susceptibility_to0.73423253
123MP0000358_abnormal_cell_content/0.73408183
124MP0001119_abnormal_female_reproductive0.73252151
125MP0003121_genomic_imprinting0.72947285
126MP0000733_abnormal_muscle_development0.71605735
127MP0002277_abnormal_respiratory_mucosa0.69428843
128MP0001845_abnormal_inflammatory_respons0.68937849
129MP0001968_abnormal_touch/_nociception0.68841445
130MP0003567_abnormal_fetal_cardiomyocyte0.68354458
131MP0004133_heterotaxia0.67078959
132MP0005076_abnormal_cell_differentiation0.66498862
133MP0010155_abnormal_intestine_physiology0.66355011
134MP0005464_abnormal_platelet_physiology0.65283630
135MP0003866_abnormal_defecation0.63895596
136MP0003656_abnormal_erythrocyte_physiolo0.63167632
137MP0001790_abnormal_immune_system0.60999341
138MP0005387_immune_system_phenotype0.60999341
139MP0002075_abnormal_coat/hair_pigmentati0.60370815
140MP0003436_decreased_susceptibility_to0.60274716
141MP0000477_abnormal_intestine_morphology0.59537662
142MP0002163_abnormal_gland_morphology0.57302040
143MP0002148_abnormal_hypersensitivity_rea0.57159829

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)4.84831042
2Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.64364252
3Abnormality of cells of the erythroid lineage (HP:0012130)4.54957947
4Dynein arm defect of respiratory motile cilia (HP:0012255)4.52530903
5Absent/shortened dynein arms (HP:0200106)4.52530903
6Abnormal number of erythroid precursors (HP:0012131)4.49877316
7Broad distal phalanx of finger (HP:0009836)3.88401918
8Male infertility (HP:0003251)3.77893966
9Abnormal respiratory epithelium morphology (HP:0012253)3.75681491
10Abnormal respiratory motile cilium morphology (HP:0005938)3.75681491
11Chromsome breakage (HP:0040012)3.73563257
12Testicular atrophy (HP:0000029)3.69510937
13Chromosomal breakage induced by crosslinking agents (HP:0003221)3.65099969
14Abnormal respiratory motile cilium physiology (HP:0012261)3.55694696
15Nasal polyposis (HP:0100582)3.44600835
16Birth length less than 3rd percentile (HP:0003561)3.38249278
17Ulnar bowing (HP:0003031)3.36629804
18Hyperacusis (HP:0010780)3.36512247
19Atelectasis (HP:0100750)3.32881516
20Aplastic anemia (HP:0001915)3.30930280
21Pallor (HP:0000980)3.25564904
22Abnormality of the preputium (HP:0100587)3.09772580
23Meckel diverticulum (HP:0002245)3.07777107
24Selective tooth agenesis (HP:0001592)3.07500926
25Abnormal ciliary motility (HP:0012262)2.97674688
2611 pairs of ribs (HP:0000878)2.97216492
27Rhinitis (HP:0012384)2.96940583
28Macrocytic anemia (HP:0001972)2.94860496
29Abnormality of the ileum (HP:0001549)2.94227722
30Abnormality of chromosome stability (HP:0003220)2.92918598
31Absent thumb (HP:0009777)2.92652117
32Aplasia/Hypoplasia of the uvula (HP:0010293)2.91932347
33Abnormality of the nasal mucosa (HP:0000433)2.86962439
34Recurrent otitis media (HP:0000403)2.85411697
35Hemorrhage of the eye (HP:0011885)2.79679194
36Chronic bronchitis (HP:0004469)2.77239876
37Myelodysplasia (HP:0002863)2.76208360
38Stridor (HP:0010307)2.74096905
39Upper limb amyotrophy (HP:0009129)2.69965972
40Distal upper limb amyotrophy (HP:0007149)2.69965972
41Oral leukoplakia (HP:0002745)2.67550790
42Thrombocytosis (HP:0001894)2.67355632
43Annular pancreas (HP:0001734)2.61504281
44Hand muscle atrophy (HP:0009130)2.60432344
45Breast hypoplasia (HP:0003187)2.58397897
46Degeneration of anterior horn cells (HP:0002398)2.57850979
47Abnormality of the anterior horn cell (HP:0006802)2.57850979
48Abnormality of the heme biosynthetic pathway (HP:0010472)2.57756804
49Bronchiectasis (HP:0002110)2.57174341
50Medulloblastoma (HP:0002885)2.56836066
51Duodenal stenosis (HP:0100867)2.54043063
52Small intestinal stenosis (HP:0012848)2.54043063
53Abnormal spermatogenesis (HP:0008669)2.52918863
54Bronchitis (HP:0012387)2.51082687
55Impulsivity (HP:0100710)2.45498056
56Ragged-red muscle fibers (HP:0003200)2.43422980
57Supernumerary spleens (HP:0009799)2.42900124
58Occipital encephalocele (HP:0002085)2.41690193
59Aplasia/Hypoplasia of the sacrum (HP:0008517)2.41531388
60Patellar aplasia (HP:0006443)2.40306316
61Bone marrow hypocellularity (HP:0005528)2.40018956
62Myopathic facies (HP:0002058)2.38577766
63Recurrent bronchitis (HP:0002837)2.33644561
64Ectopic kidney (HP:0000086)2.33095789
65Triphalangeal thumb (HP:0001199)2.30027345
66Sloping forehead (HP:0000340)2.28000770
67Aplasia/Hypoplasia of the patella (HP:0006498)2.27682062
68Abnormality of reticulocytes (HP:0004312)2.27074522
69Cleft eyelid (HP:0000625)2.26283397
70Abnormality of DNA repair (HP:0003254)2.25652017
71Basal cell carcinoma (HP:0002671)2.22679246
72Duplicated collecting system (HP:0000081)2.22047221
73Abnormality of the carotid arteries (HP:0005344)2.20691350
74Thin bony cortex (HP:0002753)2.18688196
75Nephronophthisis (HP:0000090)2.18608569
76Pancytopenia (HP:0001876)2.16945479
77Ependymoma (HP:0002888)2.15715520
78Progressive muscle weakness (HP:0003323)2.14605107
79Self-mutilation (HP:0000742)2.11468716
80Cellulitis (HP:0100658)2.11427857
81Clubbing of toes (HP:0100760)2.10300497
82Short nail (HP:0001799)2.08712821
83Abnormal number of incisors (HP:0011064)2.08083575
84Agnosia (HP:0010524)2.08012407
85Tracheoesophageal fistula (HP:0002575)2.07954236
86Asplenia (HP:0001746)2.07915174
87Obstructive lung disease (HP:0006536)2.07183381
88Chronic obstructive pulmonary disease (HP:0006510)2.07183381
89Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.06812010
90Rough bone trabeculation (HP:0100670)2.05419855
91Hypertensive crisis (HP:0100735)2.03394574
92Infertility (HP:0000789)2.03381743
93Abnormality of the distal phalanges of the toes (HP:0010182)2.01301003
94Colon cancer (HP:0003003)2.00984077
95IgM deficiency (HP:0002850)2.00240947
96Bowing of the arm (HP:0006488)1.98550954
97Bowed forearm bones (HP:0003956)1.98550954
98Abnormality of the duodenum (HP:0002246)1.97792084
99Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.97694994
100Hypoplasia of the capital femoral epiphysis (HP:0003090)1.96753313
101Neoplasm of the pancreas (HP:0002894)1.95310546
102Abnormal lung lobation (HP:0002101)1.94860383
103Vaginal fistula (HP:0004320)1.94144654
104Retinal dysplasia (HP:0007973)1.93953717
105Recurrent abscess formation (HP:0002722)1.93640753
106Petechiae (HP:0000967)1.93413567
107Aplasia/Hypoplasia of the spleen (HP:0010451)1.92427511
108Mediastinal lymphadenopathy (HP:0100721)1.92017975
109Turricephaly (HP:0000262)1.92016353
110Abnormality of the renal collecting system (HP:0004742)1.90968944
111Facial cleft (HP:0002006)1.90888439
112Optic nerve coloboma (HP:0000588)1.90550942
113Lymphoma (HP:0002665)1.88618506
114Recurrent sinusitis (HP:0011108)1.88569370
115Truncus arteriosus (HP:0001660)1.88546064
116Hypoplasia of the radius (HP:0002984)1.88303759
117Absent epiphyses (HP:0010577)1.86845436
118Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.86845436
119Premature graying of hair (HP:0002216)1.86473524
120Increased serum ferritin (HP:0003281)1.86065532
121Chronic sinusitis (HP:0011109)1.83999980
122Amaurosis fugax (HP:0100576)1.83756660
123Achilles tendon contracture (HP:0001771)1.83607479
124Carpal bone hypoplasia (HP:0001498)1.82175220
125Abnormal trabecular bone morphology (HP:0100671)1.82014775
126Horseshoe kidney (HP:0000085)1.82000202
127Progressive microcephaly (HP:0000253)1.81913373
128Rhabdomyosarcoma (HP:0002859)1.81762690
129Recurrent bacterial skin infections (HP:0005406)1.81379314
130Type I transferrin isoform profile (HP:0003642)1.80990956
131Difficulty climbing stairs (HP:0003551)1.80434468
132Insomnia (HP:0100785)1.78631089
133Gastrointestinal infarctions (HP:0005244)1.78473563
134Mesangial abnormality (HP:0001966)1.78109359
135Pulmonary fibrosis (HP:0002206)1.77855975
136Squamous cell carcinoma (HP:0002860)1.76674683
137Easy fatigability (HP:0003388)1.76547887
138Microretrognathia (HP:0000308)1.75213562
139Absent radius (HP:0003974)1.75148175
140Muscle fiber atrophy (HP:0100295)1.73983686
141Prominent nose (HP:0000448)1.73862791
142J-shaped sella turcica (HP:0002680)1.73549652
143Trismus (HP:0000211)1.73409435
144Cellular immunodeficiency (HP:0005374)1.73242927
145Increased nuchal translucency (HP:0010880)1.72229282
146Flat occiput (HP:0005469)1.71462700
147Atresia of the external auditory canal (HP:0000413)1.71445514
148Increased neuronal autofluorescent lipopigment (HP:0002074)1.70499956
149Poikiloderma (HP:0001029)1.69927436
150Abnormality of the umbilical cord (HP:0010881)1.69796190
151Cholecystitis (HP:0001082)1.69417710
152Abnormal gallbladder physiology (HP:0012438)1.69417710
153Cerebral hypomyelination (HP:0006808)1.68974473
154Secondary amenorrhea (HP:0000869)1.68847289
155Microvesicular hepatic steatosis (HP:0001414)1.68828568
156Colitis (HP:0002583)1.66573994
157Spina bifida occulta (HP:0003298)1.65292015
158Reticulocytosis (HP:0001923)1.63991381
159Dysautonomia (HP:0002459)1.63043909
160Eczematoid dermatitis (HP:0000976)1.61977893
161Abnormality of the thoracic spine (HP:0100711)1.61442337
162Abnormality of polysaccharide metabolism (HP:0011012)1.60870189
163Abnormality of glycosaminoglycan metabolism (HP:0004371)1.60870189
164Abnormality of mucopolysaccharide metabolism (HP:0011020)1.60870189
165Increased cerebral lipofuscin (HP:0011813)1.60862299
166Long palpebral fissure (HP:0000637)1.60592893
167Broad face (HP:0000283)1.60407940
168Gastrointestinal inflammation (HP:0004386)1.59889796
169Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.58762738
170Chronic otitis media (HP:0000389)1.58749194
171Long toe (HP:0010511)1.56246233
172Flattened epiphyses (HP:0003071)1.55420733
173Aplasia of the musculature (HP:0100854)1.54858715
174Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.54476271
175Prolonged neonatal jaundice (HP:0006579)1.52768924
176Elfin facies (HP:0004428)1.51697483

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.91474211
2TLK14.16645326
3SMG13.91625834
4CDC73.85491273
5BUB13.71693435
6WEE13.30477973
7ERN13.25565672
8NEK23.00220110
9MAPK152.97386883
10EIF2AK12.75960985
11STK162.31454808
12SRPK12.30228970
13NME22.10373024
14MAP3K102.09502620
15TESK12.09250023
16EEF2K2.07913870
17SIK12.07296794
18ACVR1B1.97482812
19MAP4K11.93123003
20PDK31.91462519
21PDK41.91462519
22PLK41.90548669
23TTK1.90101992
24PRPF4B1.83931147
25ATR1.77715935
26PASK1.76309693
27CDK71.73762542
28DYRK31.67037146
29VRK11.63850995
30PLK11.60111867
31TESK21.59674922
32MKNK21.56151802
33EPHA21.55263869
34SIK21.48563216
35CDK191.48403998
36TAOK21.43852514
37MKNK11.43609572
38IRAK21.43403035
39BRSK21.41495792
40TSSK61.38843754
41RPS6KB21.38164598
42TBK11.37979409
43CDK41.34984877
44CDK121.34162700
45TAOK11.34019793
46CHEK21.32855608
47AURKB1.32575831
48RPS6KA41.29933465
49PRKD21.28366220
50TGFBR11.26484996
51EIF2AK31.24560373
52BLK1.22165115
53STK101.21892801
54BTK1.20525312
55EPHB11.13906804
56CHEK11.07428292
57PRKD31.06135380
58STK41.05511657
59MAP3K31.02982874
60ICK1.02888559
61ZAP701.01316939
62AURKA1.01155276
63TEC1.00364910
64PIM10.99416218
65CCNB10.95547519
66FLT30.95488865
67BRSK10.95416204
68CDK80.94079844
69MARK20.93239030
70PAK40.92342945
71SIK30.92149127
72PIM20.92064472
73PTK60.92020094
74KIT0.91226821
75RIPK40.90339401
76PDK20.88506223
77TNK20.87313114
78ATM0.87132037
79MAP2K20.85142500
80CLK10.84466889
81PKN20.84092200
82ZAK0.84037013
83PDPK10.83586757
84MAP3K80.83201775
85MAP3K110.81289377
86BRD40.76614188
87CSK0.76008332
88JAK30.75580869
89TXK0.74669148
90ARAF0.74218334
91HIPK20.73052641
92KSR20.72223143
93IRAK40.71669869
94RPS6KA20.70020652
95PLK30.68226970
96* CDK20.67982618
97MAP2K30.67695124
98MAP3K10.66283390
99PAK10.62202405
100EIF2AK20.62090677
101CSNK2A20.60757828
102VRK20.60027122
103BMX0.58975983
104CSNK2A10.57685032
105CSF1R0.57659801
106MTOR0.56888236
107RPS6KL10.56718595
108RPS6KA50.56545633
109MUSK0.54440605
110SCYL20.53819595
111MST1R0.53312566
112IRAK30.51968155
113GRK60.51748569
114KDR0.51738636
115BCKDK0.49130264
116NME10.48297559
117MAP3K140.46240804
118MAPKAPK30.45476090
119LMTK20.45462672
120CDK10.44534188
121SYK0.43953339
122RPS6KA10.43522270
123TYK20.42064661
124CAMKK10.42048437
125ILK0.41474653
126PDK10.40836045
127CHUK0.40691535
128YES10.40098970
129HCK0.39607327
130IKBKB0.39192569
131CDK60.39149202
132NEK10.38380264
133LYN0.38107602
134LCK0.38072071
135NLK0.37205926
136BRAF0.36802662
137TTN0.36789736
138IRAK10.36119932
139CSNK1A1L0.36072408
140CSNK1G30.35735033
141DYRK1B0.35250468
142LIMK10.35120642
143IKBKE0.33620396
144BMPR1B0.33395461
145STK380.33351097
146PRKCI0.29669043
147LRRK20.29454295
148RPS6KA60.27685647
149CDK90.27678449
150AKT20.26268455
151PRKDC0.25187526
152MAPK110.25136347
153RPS6KC10.24936012

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.88812428
2Ribosome_Homo sapiens_hsa030104.04142630
3Mismatch repair_Homo sapiens_hsa034303.96652329
4Spliceosome_Homo sapiens_hsa030403.23933701
5Homologous recombination_Homo sapiens_hsa034403.18466694
6Base excision repair_Homo sapiens_hsa034103.11459799
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.03247955
8RNA polymerase_Homo sapiens_hsa030202.84603077
9Nucleotide excision repair_Homo sapiens_hsa034202.75242627
10Fanconi anemia pathway_Homo sapiens_hsa034602.75101358
11RNA transport_Homo sapiens_hsa030132.68156076
12Cell cycle_Homo sapiens_hsa041102.46415563
13Pyrimidine metabolism_Homo sapiens_hsa002402.44907265
14Proteasome_Homo sapiens_hsa030502.40340116
15Basal transcription factors_Homo sapiens_hsa030222.33898173
16One carbon pool by folate_Homo sapiens_hsa006702.24380831
17Non-homologous end-joining_Homo sapiens_hsa034502.21766330
18Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.19187003
19Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.01883624
20Glycosaminoglycan degradation_Homo sapiens_hsa005311.89861056
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.89135263
22RNA degradation_Homo sapiens_hsa030181.80725187
23mRNA surveillance pathway_Homo sapiens_hsa030151.75763916
24Non-small cell lung cancer_Homo sapiens_hsa052231.68447984
25Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.59002660
26VEGF signaling pathway_Homo sapiens_hsa043701.53432681
27Systemic lupus erythematosus_Homo sapiens_hsa053221.46931775
28Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.46709732
29p53 signaling pathway_Homo sapiens_hsa041151.44798978
30Purine metabolism_Homo sapiens_hsa002301.44597760
31Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.39122599
32Primary immunodeficiency_Homo sapiens_hsa053401.30093894
33Toll-like receptor signaling pathway_Homo sapiens_hsa046201.25327875
34Herpes simplex infection_Homo sapiens_hsa051681.24788935
35Pancreatic cancer_Homo sapiens_hsa052121.21390807
36Antigen processing and presentation_Homo sapiens_hsa046121.20730206
37Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.19695989
38Epstein-Barr virus infection_Homo sapiens_hsa051691.17043723
39Neurotrophin signaling pathway_Homo sapiens_hsa047221.11777763
40Osteoclast differentiation_Homo sapiens_hsa043801.10211228
41Sulfur relay system_Homo sapiens_hsa041221.09717459
42mTOR signaling pathway_Homo sapiens_hsa041501.05870981
43Hepatitis C_Homo sapiens_hsa051600.98455177
44Viral carcinogenesis_Homo sapiens_hsa052030.97986957
45Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.93173365
46Measles_Homo sapiens_hsa051620.87552739
47Pentose phosphate pathway_Homo sapiens_hsa000300.87149848
48Endometrial cancer_Homo sapiens_hsa052130.85986143
49HTLV-I infection_Homo sapiens_hsa051660.84594282
50TNF signaling pathway_Homo sapiens_hsa046680.83645550
51Lysosome_Homo sapiens_hsa041420.82828031
52Endocytosis_Homo sapiens_hsa041440.78540639
53Transcriptional misregulation in cancer_Homo sapiens_hsa052020.75371504
54Longevity regulating pathway - mammal_Homo sapiens_hsa042110.74783993
55Tuberculosis_Homo sapiens_hsa051520.74398385
56Oocyte meiosis_Homo sapiens_hsa041140.74062486
57Phenylalanine metabolism_Homo sapiens_hsa003600.72714471
58Selenocompound metabolism_Homo sapiens_hsa004500.72213018
59Huntingtons disease_Homo sapiens_hsa050160.70793360
60NF-kappa B signaling pathway_Homo sapiens_hsa040640.70763988
61Hematopoietic cell lineage_Homo sapiens_hsa046400.70349626
62Sphingolipid metabolism_Homo sapiens_hsa006000.68862858
63Legionellosis_Homo sapiens_hsa051340.68114324
64Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.67048540
65Adipocytokine signaling pathway_Homo sapiens_hsa049200.66561486
66Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.65931624
67Sphingolipid signaling pathway_Homo sapiens_hsa040710.65219736
68Vibrio cholerae infection_Homo sapiens_hsa051100.63546575
69Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.63200825
70AMPK signaling pathway_Homo sapiens_hsa041520.62762989
71Salmonella infection_Homo sapiens_hsa051320.62011775
72Insulin signaling pathway_Homo sapiens_hsa049100.61537538
73Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.60675050
74Vitamin B6 metabolism_Homo sapiens_hsa007500.60472692
75Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.60404047
76Thyroid hormone signaling pathway_Homo sapiens_hsa049190.60172586
77Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.59560852
78Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.59295119
79Cyanoamino acid metabolism_Homo sapiens_hsa004600.59090600
80N-Glycan biosynthesis_Homo sapiens_hsa005100.58294280
81Alcoholism_Homo sapiens_hsa050340.56702289
82Acute myeloid leukemia_Homo sapiens_hsa052210.56134671
83Inositol phosphate metabolism_Homo sapiens_hsa005620.54371103
84Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.54115557
85Protein export_Homo sapiens_hsa030600.53262530
86Small cell lung cancer_Homo sapiens_hsa052220.53100476
87Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.52928322
88Apoptosis_Homo sapiens_hsa042100.52911746
89Cysteine and methionine metabolism_Homo sapiens_hsa002700.52630365
90Intestinal immune network for IgA production_Homo sapiens_hsa046720.52338190
91Glioma_Homo sapiens_hsa052140.52337467
92Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.47803716
93Influenza A_Homo sapiens_hsa051640.47489271
94Choline metabolism in cancer_Homo sapiens_hsa052310.46828710
95Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.46711952
96RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.46468828
97B cell receptor signaling pathway_Homo sapiens_hsa046620.45829699
98Hepatitis B_Homo sapiens_hsa051610.45672838
99Notch signaling pathway_Homo sapiens_hsa043300.45363139
100Prostate cancer_Homo sapiens_hsa052150.44893015
101Thyroid cancer_Homo sapiens_hsa052160.43802062
102Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.43417042
103Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.43144093
104Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.42875514
105Insulin resistance_Homo sapiens_hsa049310.42563848
106Basal cell carcinoma_Homo sapiens_hsa052170.41975597
107Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.40633904
108Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.40094633
109Jak-STAT signaling pathway_Homo sapiens_hsa046300.39728009
110Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.39094387
111MicroRNAs in cancer_Homo sapiens_hsa052060.38932378
112Shigellosis_Homo sapiens_hsa051310.37606265
113T cell receptor signaling pathway_Homo sapiens_hsa046600.36034106
114Folate biosynthesis_Homo sapiens_hsa007900.34919508
115Chronic myeloid leukemia_Homo sapiens_hsa052200.33808317
116Asthma_Homo sapiens_hsa053100.32893647
117Leishmaniasis_Homo sapiens_hsa051400.32768552
118Allograft rejection_Homo sapiens_hsa053300.32727549
119Biosynthesis of amino acids_Homo sapiens_hsa012300.31312518
120Drug metabolism - other enzymes_Homo sapiens_hsa009830.31222463
121NOD-like receptor signaling pathway_Homo sapiens_hsa046210.30302893
122Fructose and mannose metabolism_Homo sapiens_hsa000510.29616657
123Glutathione metabolism_Homo sapiens_hsa004800.29463045
124Arachidonic acid metabolism_Homo sapiens_hsa005900.29347459
125Other glycan degradation_Homo sapiens_hsa005110.22869600
126Parkinsons disease_Homo sapiens_hsa050120.21740342
127Pathways in cancer_Homo sapiens_hsa052000.21177839
128Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.19636791
129Colorectal cancer_Homo sapiens_hsa052100.19005573
130Bladder cancer_Homo sapiens_hsa052190.18666792
131Linoleic acid metabolism_Homo sapiens_hsa005910.18558842
132Central carbon metabolism in cancer_Homo sapiens_hsa052300.18252575
133Renin-angiotensin system_Homo sapiens_hsa046140.17761676
134Toxoplasmosis_Homo sapiens_hsa051450.17309746
135Autoimmune thyroid disease_Homo sapiens_hsa053200.17251764
136Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.17055719
137Viral myocarditis_Homo sapiens_hsa054160.16496525
138HIF-1 signaling pathway_Homo sapiens_hsa040660.16151843
139Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.15676633
140Galactose metabolism_Homo sapiens_hsa000520.15348373

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »