LSM1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the LSm family of RNA-binding proteins. LSm proteins form stable heteromers that bind specifically to the 3'-terminal oligo(U) tract of U6 snRNA and may play a role in pre-mRNA splicing by mediating U4/U6 snRNP formation. Increased expression of this gene may play a role in cellular transformation and the progression of several malignancies including lung cancer, mesothelioma and breast cancer. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein neddylation (GO:0045116)6.90637188
2DNA deamination (GO:0045006)5.73818355
3ribosomal small subunit assembly (GO:0000028)5.37496673
4mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.36860035
5proteasome assembly (GO:0043248)5.00727629
6viral transcription (GO:0019083)4.99975457
7translational termination (GO:0006415)4.92373045
8respiratory electron transport chain (GO:0022904)4.89495926
9electron transport chain (GO:0022900)4.80381789
10maturation of SSU-rRNA (GO:0030490)4.79253649
11ribosomal small subunit biogenesis (GO:0042274)4.75378259
12SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.46730790
13cotranslational protein targeting to membrane (GO:0006613)4.40782252
14translational elongation (GO:0006414)4.39284249
15protein targeting to ER (GO:0045047)4.35475845
16negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.28078277
17protein localization to endoplasmic reticulum (GO:0070972)4.14714576
18transcription elongation from RNA polymerase III promoter (GO:0006385)4.14450440
19termination of RNA polymerase III transcription (GO:0006386)4.14450440
20DNA strand elongation involved in DNA replication (GO:0006271)4.13943618
21establishment of protein localization to endoplasmic reticulum (GO:0072599)4.11501583
22ribosomal large subunit biogenesis (GO:0042273)4.10385263
23translational initiation (GO:0006413)4.09141701
24mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.05652004
25establishment of integrated proviral latency (GO:0075713)4.05458639
26positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.99515842
27formation of translation preinitiation complex (GO:0001731)3.98773730
28regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.97332360
29telomere maintenance via semi-conservative replication (GO:0032201)3.97009773
307-methylguanosine mRNA capping (GO:0006370)3.96896537
31cellular protein complex disassembly (GO:0043624)3.96742849
32protein deneddylation (GO:0000338)3.96609883
33DNA strand elongation (GO:0022616)3.94712649
34cullin deneddylation (GO:0010388)3.93079483
357-methylguanosine RNA capping (GO:0009452)3.91108690
36RNA capping (GO:0036260)3.91108690
37negative regulation of ligase activity (GO:0051352)3.90401431
38negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.90401431
39respiratory chain complex IV assembly (GO:0008535)3.90344896
40anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.90213708
41viral life cycle (GO:0019058)3.89018389
42nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.86021167
43ribonucleoprotein complex biogenesis (GO:0022613)3.85751326
44protein localization to mitochondrion (GO:0070585)3.85605874
45translation (GO:0006412)3.82215689
46deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.81876933
47energy coupled proton transport, down electrochemical gradient (GO:0015985)3.78276555
48ATP synthesis coupled proton transport (GO:0015986)3.78276555
49L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.77763449
50regulation of cellular amino acid metabolic process (GO:0006521)3.69215570
51DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.69097177
52pseudouridine synthesis (GO:0001522)3.68349245
53spliceosomal snRNP assembly (GO:0000387)3.67181410
54DNA replication checkpoint (GO:0000076)3.64769947
55signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.63586402
56intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.63586402
57platelet dense granule organization (GO:0060155)3.60943302
58signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.60910664
59signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.60910664
60signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.60910664
61DNA replication initiation (GO:0006270)3.58116917
62transcription-coupled nucleotide-excision repair (GO:0006283)3.57253117
63telomere maintenance via recombination (GO:0000722)3.56475666
64oxidative phosphorylation (GO:0006119)3.56028885
65positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.52581148
66rRNA processing (GO:0006364)3.51972625
67CENP-A containing nucleosome assembly (GO:0034080)3.50860123
68signal transduction involved in DNA damage checkpoint (GO:0072422)3.50488979
69signal transduction involved in DNA integrity checkpoint (GO:0072401)3.50488979
70establishment of viral latency (GO:0019043)3.50300900
71GTP biosynthetic process (GO:0006183)3.48593875
72purine nucleobase biosynthetic process (GO:0009113)3.47762044
73ribosome biogenesis (GO:0042254)3.45838803
74antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.45742404
75signal transduction involved in cell cycle checkpoint (GO:0072395)3.45162518
76protein complex disassembly (GO:0043241)3.43878597
77rRNA modification (GO:0000154)3.43842178
78cytochrome complex assembly (GO:0017004)3.43633180
79nucleobase biosynthetic process (GO:0046112)3.43473049
80cellular component biogenesis (GO:0044085)3.42523964
81chromatin remodeling at centromere (GO:0031055)3.41930034
82positive regulation of ligase activity (GO:0051351)3.41352747
83* exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.39063764
84rRNA metabolic process (GO:0016072)3.38507826
85* nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.36967255
86guanosine-containing compound biosynthetic process (GO:1901070)3.36359380
87regulation of mitochondrial translation (GO:0070129)3.35443954
88peptidyl-histidine modification (GO:0018202)3.34211461
89macromolecular complex disassembly (GO:0032984)3.32551679
90rRNA methylation (GO:0031167)3.31669709
91tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.30215433
92RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.30215433
93maturation of 5.8S rRNA (GO:0000460)3.29797629
94protein-cofactor linkage (GO:0018065)3.26092143
95nucleotide-excision repair, DNA gap filling (GO:0006297)3.25584877
96mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.24440088
97mitochondrial respiratory chain complex I assembly (GO:0032981)3.24440088
98NADH dehydrogenase complex assembly (GO:0010257)3.24440088
99mitotic recombination (GO:0006312)3.23760700
100UTP biosynthetic process (GO:0006228)3.23413093
101pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.22935651
102antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.21187220
103mitochondrial transport (GO:0006839)3.19831421
104ribosome assembly (GO:0042255)3.17685526
105hydrogen ion transmembrane transport (GO:1902600)3.17331728
106protein complex biogenesis (GO:0070271)3.16837019
107purine nucleoside triphosphate biosynthetic process (GO:0009145)3.16803705
108protein targeting to mitochondrion (GO:0006626)3.16435579
109ATP biosynthetic process (GO:0006754)3.15338964
110purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.14998973
111regulation of ubiquitin-protein transferase activity (GO:0051438)3.14823120
112establishment of protein localization to mitochondrial membrane (GO:0090151)3.14774940
113spliceosomal complex assembly (GO:0000245)3.14264001
114establishment of protein localization to mitochondrion (GO:0072655)3.14120682
115chaperone-mediated protein transport (GO:0072321)3.13783972
116pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.13756014
117transcription elongation from RNA polymerase I promoter (GO:0006362)3.13307947
118cell cycle G1/S phase transition (GO:0044843)3.13203278
119G1/S transition of mitotic cell cycle (GO:0000082)3.13203278
120mitochondrial respiratory chain complex assembly (GO:0033108)3.10276552
121inner mitochondrial membrane organization (GO:0007007)3.08046057
122regulation of ligase activity (GO:0051340)3.00678151
123regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.00324911
124regulation of mitotic spindle checkpoint (GO:1903504)3.00324911
125protein maturation by protein folding (GO:0022417)2.98481395
126water-soluble vitamin biosynthetic process (GO:0042364)2.96589220
127intracellular protein transmembrane import (GO:0044743)2.94382623
128regulation of cellular amine metabolic process (GO:0033238)2.89817104
129histone exchange (GO:0043486)2.86517242
130proton transport (GO:0015992)2.84150692

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.54834845
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.63343291
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.53111080
4* GABP_17652178_ChIP-ChIP_JURKAT_Human4.18069854
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.97788944
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.95349382
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.81954785
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.61712616
9HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.29790041
10CREB1_15753290_ChIP-ChIP_HEK293T_Human3.26047069
11MYC_18358816_ChIP-ChIP_MESCs_Mouse3.23707320
12NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.11360097
13* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.99671418
14CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.96786551
15MYC_19079543_ChIP-ChIP_MESCs_Mouse2.95685202
16SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.95600046
17E2F4_17652178_ChIP-ChIP_JURKAT_Human2.83946981
18HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.81322320
19E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.74489850
20VDR_23849224_ChIP-Seq_CD4+_Human2.73252214
21XRN2_22483619_ChIP-Seq_HELA_Human2.60191178
22FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.56227399
23DCP1A_22483619_ChIP-Seq_HELA_Human2.48136623
24NELFA_20434984_ChIP-Seq_ESCs_Mouse2.46027631
25ELF1_17652178_ChIP-ChIP_JURKAT_Human2.45760603
26E2F1_18555785_ChIP-Seq_MESCs_Mouse2.41332967
27CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.34018640
28THAP11_20581084_ChIP-Seq_MESCs_Mouse2.31505669
29FOXP3_21729870_ChIP-Seq_TREG_Human2.28624170
30TTF2_22483619_ChIP-Seq_HELA_Human2.22139823
31* GABP_19822575_ChIP-Seq_HepG2_Human2.20552277
32SRF_21415370_ChIP-Seq_HL-1_Mouse2.17000116
33ELK1_19687146_ChIP-ChIP_HELA_Human2.07892301
34FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.03967175
35YY1_21170310_ChIP-Seq_MESCs_Mouse2.02481787
36SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.99254328
37MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.94990856
38FOXM1_23109430_ChIP-Seq_U2OS_Human1.87115061
39PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.86280235
40FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.85527000
41PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.80848580
42MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.79684089
43ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.79071650
44HOXB4_20404135_ChIP-ChIP_EML_Mouse1.78115652
45* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.77457967
46* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.75398132
47MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.73294390
48POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.68738516
49* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.64981363
50ZFX_18555785_ChIP-Seq_MESCs_Mouse1.63051079
51RBPJ_22232070_ChIP-Seq_NCS_Mouse1.58885603
52YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.58012394
53CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.55557425
54NANOG_18555785_ChIP-Seq_MESCs_Mouse1.53488470
55VDR_22108803_ChIP-Seq_LS180_Human1.50930516
56EWS_26573619_Chip-Seq_HEK293_Human1.50126340
57ERG_20887958_ChIP-Seq_HPC-7_Mouse1.49209035
58E2F1_21310950_ChIP-Seq_MCF-7_Human1.47193340
59ELK1_22589737_ChIP-Seq_MCF10A_Human1.46111987
60FLI1_27457419_Chip-Seq_LIVER_Mouse1.43452164
61* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.39031565
62MYC_18940864_ChIP-ChIP_HL60_Human1.36653078
63CIITA_25753668_ChIP-Seq_RAJI_Human1.36354540
64POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.32900759
65TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.30329594
66ZNF274_21170338_ChIP-Seq_K562_Hela1.29918929
67CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.29057773
68NOTCH1_21737748_ChIP-Seq_TLL_Human1.26218626
69AR_21909140_ChIP-Seq_LNCAP_Human1.25544747
70PADI4_21655091_ChIP-ChIP_MCF-7_Human1.24851967
71HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.20327724
72HTT_18923047_ChIP-ChIP_STHdh_Human1.16834558
73KDM5A_27292631_Chip-Seq_BREAST_Human1.16453730
74CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.15278252
75ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.15270012
76CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.14807248
77SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.12242550
78KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.09995402
79BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.08967414
80E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.08922404
81IGF1R_20145208_ChIP-Seq_DFB_Human1.07737577
82GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.03201068
83NANOG_16153702_ChIP-ChIP_HESCs_Human1.03089230
84* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.01869513
85PCGF2_27294783_Chip-Seq_ESCs_Mouse1.01401472
86TP53_22573176_ChIP-Seq_HFKS_Human1.00452391
87CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.99042753
88POU5F1_16153702_ChIP-ChIP_HESCs_Human0.98930590
89* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.97576518
90CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.96550086
91EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.96123784
92SOX2_16153702_ChIP-ChIP_HESCs_Human0.92711955
93* SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.92678362
94CTCF_18555785_ChIP-Seq_MESCs_Mouse0.92524732
95TP63_19390658_ChIP-ChIP_HaCaT_Human0.92293941
96ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.92084891
97POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.90684901
98TFEB_21752829_ChIP-Seq_HELA_Human0.90405346
99ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.88825088
100SPI1_23547873_ChIP-Seq_NB4_Human0.88074445
101DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.87827589
102SOX2_18555785_ChIP-Seq_MESCs_Mouse0.87321633
103IRF1_19129219_ChIP-ChIP_H3396_Human0.87227465
104POU3F2_20337985_ChIP-ChIP_501MEL_Human0.86945496
105IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.86519564
106* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86479739
107STAT3_1855785_ChIP-Seq_MESCs_Mouse0.86233981
108HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.84828163
109GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84617738
110AR_20517297_ChIP-Seq_VCAP_Human0.84585734
111FUS_26573619_Chip-Seq_HEK293_Human0.84462831
112* KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.83179320
113DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.83155898
114ERG_20517297_ChIP-Seq_VCAP_Human0.82698448
115CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.80706971
116SOX17_20123909_ChIP-Seq_XEN_Mouse0.80160334
117MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.78299689
118OCT4_18692474_ChIP-Seq_MEFs_Mouse0.74715249
119P300_19829295_ChIP-Seq_ESCs_Human0.73999781
120SALL4_22934838_ChIP-ChIP_CD34+_Human0.73851805
121TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.73217916
122NFE2_27457419_Chip-Seq_LIVER_Mouse0.71872464
123NANOG_19829295_ChIP-Seq_ESCs_Human0.71507088
124SOX2_19829295_ChIP-Seq_ESCs_Human0.71507088
125TBX5_21415370_ChIP-Seq_HL-1_Mouse0.69491492
126SOX2_18692474_ChIP-Seq_MEFs_Mouse0.68237619
127SRY_22984422_ChIP-ChIP_TESTIS_Rat0.66904692
128KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.65919192

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.26011779
2MP0004957_abnormal_blastocyst_morpholog4.30992111
3MP0010094_abnormal_chromosome_stability3.90544221
4MP0008058_abnormal_DNA_repair3.56426460
5MP0003077_abnormal_cell_cycle3.54274773
6MP0009379_abnormal_foot_pigmentation3.51480477
7MP0003111_abnormal_nucleus_morphology3.32701290
8MP0003011_delayed_dark_adaptation3.01621015
9MP0008057_abnormal_DNA_replication2.99012399
10MP0008932_abnormal_embryonic_tissue2.91344337
11MP0001529_abnormal_vocalization2.64606679
12MP0002837_dystrophic_cardiac_calcinosis2.58837455
13MP0008007_abnormal_cellular_replicative2.44496128
14MP0002102_abnormal_ear_morphology2.38432014
15MP0003718_maternal_effect2.24177533
16MP0003186_abnormal_redox_activity2.07750621
17MP0003786_premature_aging2.02190380
18MP0002736_abnormal_nociception_after1.95376753
19MP0005464_abnormal_platelet_physiology1.91943244
20MP0008877_abnormal_DNA_methylation1.87711002
21MP0003123_paternal_imprinting1.83355340
22MP0003763_abnormal_thymus_physiology1.77203595
23MP0006292_abnormal_olfactory_placode1.75553091
24MP0008004_abnormal_stomach_pH1.70456405
25MP0003806_abnormal_nucleotide_metabolis1.68307473
26MP0006036_abnormal_mitochondrial_physio1.68028151
27MP0000490_abnormal_crypts_of1.67730270
28MP0002132_abnormal_respiratory_system1.64840945
29MP0000350_abnormal_cell_proliferation1.64074605
30MP0006035_abnormal_mitochondrial_morpho1.61983274
31MP0009333_abnormal_splenocyte_physiolog1.51019063
32MP0005253_abnormal_eye_physiology1.47929526
33MP0001730_embryonic_growth_arrest1.47226894
34MP0002638_abnormal_pupillary_reflex1.47067604
35MP0002396_abnormal_hematopoietic_system1.46556211
36MP0004215_abnormal_myocardial_fiber1.44649055
37MP0001905_abnormal_dopamine_level1.44482323
38MP0010030_abnormal_orbit_morphology1.43701398
39MP0002160_abnormal_reproductive_system1.41471213
40MP0002210_abnormal_sex_determination1.37242721
41MP0000313_abnormal_cell_death1.35743394
42MP0001188_hyperpigmentation1.33590309
43MP0005671_abnormal_response_to1.32485403
44MP0003941_abnormal_skin_development1.30424826
45MP0002163_abnormal_gland_morphology1.28773817
46MP0008789_abnormal_olfactory_epithelium1.27562475
47MP0001542_abnormal_bone_strength1.27558957
48MP0002019_abnormal_tumor_incidence1.25706956
49MP0005410_abnormal_fertilization1.22483276
50MP0001697_abnormal_embryo_size1.22083791
51MP0009697_abnormal_copulation1.21814212
52MP0000358_abnormal_cell_content/1.21087464
53MP0002938_white_spotting1.19748577
54MP0001145_abnormal_male_reproductive1.19476040
55MP0005389_reproductive_system_phenotype1.18954488
56MP0005083_abnormal_biliary_tract1.17746572
57MP0008872_abnormal_physiological_respon1.16807905
58MP0002090_abnormal_vision1.16021202
59MP0003315_abnormal_perineum_morphology1.15998405
60MP0006276_abnormal_autonomic_nervous1.14637232
61MP0001835_abnormal_antigen_presentation1.14465082
62MP0005075_abnormal_melanosome_morpholog1.14102873
63MP0000343_altered_response_to1.12859089
64MP0000653_abnormal_sex_gland1.12544061
65MP0001929_abnormal_gametogenesis1.11721984
66MP0002398_abnormal_bone_marrow1.10413965
67MP0000372_irregular_coat_pigmentation1.09286694
68MP0002234_abnormal_pharynx_morphology1.08449883
69MP0005174_abnormal_tail_pigmentation1.06868246
70MP0000230_abnormal_systemic_arterial1.05961173
71MP0001986_abnormal_taste_sensitivity1.05533985
72MP0002876_abnormal_thyroid_physiology1.04686370
73MP0002080_prenatal_lethality1.04560356
74MP0005551_abnormal_eye_electrophysiolog1.03865592
75MP0004808_abnormal_hematopoietic_stem1.02219843
76MP0002751_abnormal_autonomic_nervous1.01740643
77MP0000703_abnormal_thymus_morphology1.00456926
78MP0003567_abnormal_fetal_cardiomyocyte0.98714006
79MP0000689_abnormal_spleen_morphology0.98460828
80MP0001119_abnormal_female_reproductive0.97784751
81MP0002722_abnormal_immune_system0.96610468
82MP0001853_heart_inflammation0.95320771
83MP0001919_abnormal_reproductive_system0.95149681
84MP0002095_abnormal_skin_pigmentation0.94221248
85MP0002277_abnormal_respiratory_mucosa0.91158431
86MP0001545_abnormal_hematopoietic_system0.90454012
87MP0005397_hematopoietic_system_phenotyp0.90454012
88MP0000015_abnormal_ear_pigmentation0.90325129
89MP0008775_abnormal_heart_ventricle0.89697502
90MP0004147_increased_porphyrin_level0.88378585
91MP0003121_genomic_imprinting0.88187720
92MP0005408_hypopigmentation0.87905844
93MP0008995_early_reproductive_senescence0.87794329
94MP0009785_altered_susceptibility_to0.87606654
95MP0002429_abnormal_blood_cell0.87311816
96MP0002653_abnormal_ependyma_morphology0.87204908
97MP0003136_yellow_coat_color0.86602761
98MP0004133_heterotaxia0.85787946
99MP0005646_abnormal_pituitary_gland0.85526509
100MP0006072_abnormal_retinal_apoptosis0.84855954
101MP0002085_abnormal_embryonic_tissue0.84554725
102MP0001968_abnormal_touch/_nociception0.83988401
103MP0002233_abnormal_nose_morphology0.82143340
104MP0005380_embryogenesis_phenotype0.81746964
105MP0001672_abnormal_embryogenesis/_devel0.81746964
106MP0003880_abnormal_central_pattern0.81331755
107MP0005332_abnormal_amino_acid0.81321215
108MP0000049_abnormal_middle_ear0.80415886
109MP0000716_abnormal_immune_system0.80346081
110MP0003787_abnormal_imprinting0.79865766
111MP0005379_endocrine/exocrine_gland_phen0.79093856
112MP0001764_abnormal_homeostasis0.77292935
113MP0005636_abnormal_mineral_homeostasis0.75679572
114MP0001984_abnormal_olfaction0.73347894
115MP0001293_anophthalmia0.72557177
116MP0000858_altered_metastatic_potential0.71218892
117MP0005451_abnormal_body_composition0.70174735
118MP0001881_abnormal_mammary_gland0.68255515
119MP0005266_abnormal_metabolism0.68081049
120MP0002420_abnormal_adaptive_immunity0.67616248
121MP0003119_abnormal_digestive_system0.66237144
122MP0001819_abnormal_immune_cell0.65685290
123MP0005499_abnormal_olfactory_system0.64872247
124MP0005394_taste/olfaction_phenotype0.64872247
125MP0003283_abnormal_digestive_organ0.64629912
126MP0005085_abnormal_gallbladder_physiolo0.64413425
127MP0010386_abnormal_urinary_bladder0.64377828
128MP0004142_abnormal_muscle_tone0.64288674
129MP0003984_embryonic_growth_retardation0.63799938
130MP0002148_abnormal_hypersensitivity_rea0.63091986
131MP0005084_abnormal_gallbladder_morpholo0.61588005
132MP0008260_abnormal_autophagy0.61194599
133MP0003937_abnormal_limbs/digits/tail_de0.60961536
134MP0000749_muscle_degeneration0.60724902
135MP0001485_abnormal_pinna_reflex0.60467161
136MP0001661_extended_life_span0.59909322
137MP0003698_abnormal_male_reproductive0.58971387
138MP0003195_calcinosis0.58854305

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)5.14674842
2Abnormal number of erythroid precursors (HP:0012131)4.81452552
3Birth length less than 3rd percentile (HP:0003561)4.59604398
4Acute necrotizing encephalopathy (HP:0006965)4.56993510
5Increased hepatocellular lipid droplets (HP:0006565)4.50132763
6Mitochondrial inheritance (HP:0001427)4.46575600
7Reticulocytopenia (HP:0001896)4.37852596
8Abnormal mitochondria in muscle tissue (HP:0008316)4.17421249
9Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)4.07489091
10Hepatocellular necrosis (HP:0001404)4.07153742
11Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.02132000
12Decreased activity of mitochondrial respiratory chain (HP:0008972)4.02132000
13Increased CSF lactate (HP:0002490)4.01927688
14Lipid accumulation in hepatocytes (HP:0006561)3.97647251
15Breast hypoplasia (HP:0003187)3.75011623
16Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.73716895
17Macrocytic anemia (HP:0001972)3.64569830
183-Methylglutaconic aciduria (HP:0003535)3.62365233
19Progressive macrocephaly (HP:0004481)3.60306279
20Renal Fanconi syndrome (HP:0001994)3.59095085
21Exertional dyspnea (HP:0002875)3.55505283
22Aplastic anemia (HP:0001915)3.55294182
23Pallor (HP:0000980)3.50921743
24Hepatic necrosis (HP:0002605)3.50701616
25Acute encephalopathy (HP:0006846)3.47349315
26Increased serum lactate (HP:0002151)3.41316315
27Increased intramyocellular lipid droplets (HP:0012240)3.18291829
28Respiratory difficulties (HP:0002880)3.17882429
29Cerebral hypomyelination (HP:0006808)3.10809773
30Aplasia/Hypoplasia of the sacrum (HP:0008517)3.08015011
31Type I transferrin isoform profile (HP:0003642)3.07398749
32Oral leukoplakia (HP:0002745)2.98278451
33Exercise intolerance (HP:0003546)2.90197574
34Microvesicular hepatic steatosis (HP:0001414)2.81866505
35Rough bone trabeculation (HP:0100670)2.76064182
36Abnormality of the anterior horn cell (HP:0006802)2.74845121
37Degeneration of anterior horn cells (HP:0002398)2.74845121
38Lactic acidosis (HP:0003128)2.72608126
39Microretrognathia (HP:0000308)2.71431123
40Abnormality of glycolysis (HP:0004366)2.65272461
41Increased serum pyruvate (HP:0003542)2.65272461
42Carpal bone hypoplasia (HP:0001498)2.61994640
43Increased muscle lipid content (HP:0009058)2.59705304
44Generalized aminoaciduria (HP:0002909)2.56135964
45Lethargy (HP:0001254)2.55205011
46Methylmalonic acidemia (HP:0002912)2.52577607
47Respiratory failure (HP:0002878)2.52262503
48Colon cancer (HP:0003003)2.48860026
49Abnormality of the heme biosynthetic pathway (HP:0010472)2.46685718
50Patellar aplasia (HP:0006443)2.43909592
51Petechiae (HP:0000967)2.39733996
52Methylmalonic aciduria (HP:0012120)2.38610839
53Abnormality of alanine metabolism (HP:0010916)2.38130950
54Hyperalaninemia (HP:0003348)2.38130950
55Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.38130950
56Abnormality of the labia minora (HP:0012880)2.35606317
5711 pairs of ribs (HP:0000878)2.34940666
58Poor head control (HP:0002421)2.33744142
59Aplasia/Hypoplasia of the patella (HP:0006498)2.33058242
60Absent thumb (HP:0009777)2.31360985
61Congenital, generalized hypertrichosis (HP:0004540)2.30964320
62Reduced antithrombin III activity (HP:0001976)2.29191095
63Cerebral edema (HP:0002181)2.23661189
64Premature graying of hair (HP:0002216)2.22365719
65Hyperglycinemia (HP:0002154)2.19950923
66Abnormality of renal resorption (HP:0011038)2.16521203
67Glycosuria (HP:0003076)2.15296805
68Abnormality of urine glucose concentration (HP:0011016)2.15296805
69Pancreatic cysts (HP:0001737)2.13688223
70Pancreatic fibrosis (HP:0100732)2.13682668
71Triphalangeal thumb (HP:0001199)2.13635824
72Abnormality of the preputium (HP:0100587)2.11993184
73Abnormality of methionine metabolism (HP:0010901)2.10466366
74X-linked dominant inheritance (HP:0001423)2.09530753
75Optic disc pallor (HP:0000543)2.09510867
76Abnormality of serum amino acid levels (HP:0003112)2.08360838
77Cleft eyelid (HP:0000625)2.08216308
78Short middle phalanx of the 5th finger (HP:0004220)2.08038322
79Secondary amenorrhea (HP:0000869)2.07468169
80Abnormal protein glycosylation (HP:0012346)2.06918465
81Abnormal glycosylation (HP:0012345)2.06918465
82Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.06918465
83Abnormal protein N-linked glycosylation (HP:0012347)2.06918465
84Abnormality of midbrain morphology (HP:0002418)2.06824604
85Molar tooth sign on MRI (HP:0002419)2.06824604
86Leukodystrophy (HP:0002415)2.05268855
87Muscle fiber atrophy (HP:0100295)2.05038276
88Pancytopenia (HP:0001876)2.03649848
89Irregular epiphyses (HP:0010582)2.03404520
90Meckel diverticulum (HP:0002245)2.03117315
91CNS hypomyelination (HP:0003429)2.02311770
92Supernumerary spleens (HP:0009799)2.02224989
93Abnormal trabecular bone morphology (HP:0100671)2.00837099
94Nausea (HP:0002018)2.00345372
95Amniotic constriction ring (HP:0009775)1.96821353
96Abnormality of placental membranes (HP:0011409)1.96821353
97Abnormality of the ileum (HP:0001549)1.96076304
98Horseshoe kidney (HP:0000085)1.95787721
99Type 2 muscle fiber atrophy (HP:0003554)1.95041117
100Premature ovarian failure (HP:0008209)1.94256988
101Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.93000286
102Emotional lability (HP:0000712)1.90583670
103Abnormality of aspartate family amino acid metabolism (HP:0010899)1.90228169
104Absent radius (HP:0003974)1.90220464
105Cellular immunodeficiency (HP:0005374)1.89901354
106Bone marrow hypocellularity (HP:0005528)1.87361753
107Abnormal pupillary function (HP:0007686)1.86635597
108CNS demyelination (HP:0007305)1.84190821
109Trismus (HP:0000211)1.82353498
110Myelodysplasia (HP:0002863)1.81567446
111Abnormal lung lobation (HP:0002101)1.81046932
112Dicarboxylic aciduria (HP:0003215)1.80463040
113Abnormality of dicarboxylic acid metabolism (HP:0010995)1.80463040
114Hypoplasia of the radius (HP:0002984)1.79712962
115Aplasia/Hypoplasia of the uvula (HP:0010293)1.79469070
116Abnormality of chromosome stability (HP:0003220)1.78920622
117Aplasia involving forearm bones (HP:0009822)1.77706780
118Absent forearm bone (HP:0003953)1.77706780
119Abolished electroretinogram (ERG) (HP:0000550)1.77538195
120Hyperphosphaturia (HP:0003109)1.77380877
121Atrophy/Degeneration involving motor neurons (HP:0007373)1.75890832
122Blindness (HP:0000618)1.75763674
123Severe combined immunodeficiency (HP:0004430)1.75756861
124Dyschromatopsia (HP:0007641)1.74999831
125True hermaphroditism (HP:0010459)1.72074603
126Thrombocytosis (HP:0001894)1.72036123
127Multiple enchondromatosis (HP:0005701)1.71533631
128Aplasia/Hypoplasia involving the musculature (HP:0001460)1.70308682
129Sclerocornea (HP:0000647)1.68703629
130Increased mean platelet volume (HP:0011877)1.68125678
131Aplasia/hypoplasia of the uterus (HP:0008684)1.67259780
132Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.64780660
133Sparse eyelashes (HP:0000653)1.64030829
134Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.63271311
135Medial flaring of the eyebrow (HP:0010747)1.62634272
136Aplasia/Hypoplasia of the fovea (HP:0008060)1.59860654
137Hypoplasia of the fovea (HP:0007750)1.59860654

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.67907824
2STK164.66563874
3NME24.32351967
4WEE13.47383161
5EIF2AK12.95849437
6TESK22.85591050
7VRK12.79729176
8TRIM282.79570994
9CDC72.67973560
10SRPK12.66452962
11VRK22.63645049
12PLK42.33071247
13TLK12.30065370
14ARAF2.19482697
15PIM22.07695185
16ACVR1B2.01409555
17MYLK1.90572442
18EIF2AK31.86849797
19DYRK31.79834587
20NME11.76647695
21NUAK11.72810652
22BRAF1.71208758
23PDK21.57322396
24BRSK21.54219257
25PLK11.50475048
26DYRK21.43866271
27AURKA1.42679722
28CDK81.40094085
29TSSK61.36849633
30PLK21.35727747
31KDR1.31281459
32PLK31.30485943
33LIMK11.29769486
34MAP3K121.29310830
35MAP3K111.23643147
36MAP4K21.23471398
37RPS6KA41.22443010
38PINK11.20687405
39CDK191.19072261
40GRK11.16660775
41NEK21.14431630
42TESK11.13053123
43MKNK11.12627577
44AURKB1.10988187
45TTK1.10912281
46PBK1.08420722
47CDK71.01744323
48CSNK1G21.00249935
49BRSK10.95736585
50ATR0.93705474
51CHEK20.92294517
52SCYL20.90280712
53RPS6KB20.90139598
54MST40.88742049
55ABL20.88614905
56ERBB30.88437136
57MKNK20.86299822
58RAF10.85857279
59MAP3K40.81326781
60PASK0.80454373
61ZAK0.79122813
62STK30.75405310
63CSNK1A1L0.71735591
64ADRBK20.69751616
65CSNK2A10.69658476
66BCKDK0.68993096
67DAPK30.68282325
68CSNK1G30.67416240
69BCR0.67283095
70TGFBR10.66525157
71RPS6KA50.65857604
72MUSK0.65552647
73TXK0.65550245
74CSNK2A20.65479910
75NEK10.65369076
76PAK30.64665374
77TAOK30.64566339
78TNIK0.64288495
79BMPR1B0.63601986
80GRK70.61363392
81EIF2AK20.60188545
82MAP3K80.59792200
83CCNB10.59019841
84MAPK130.58757638
85PAK10.58199648
86TAF10.57806953
87PRKCI0.56669110
88MAPKAPK30.56327278
89GRK50.56157776
90ILK0.56096801
91KIT0.54828994
92MAP2K70.53845582
93DAPK10.51272238
94MINK10.51269643
95MAP4K10.50539887
96ZAP700.50458785
97ADRBK10.50364713
98CHEK10.48945197
99LRRK20.48397544
100PIK3CG0.47899904
101MOS0.45669818
102MARK30.45238508
103PIM10.43808610
104PAK40.43115042
105IKBKB0.41867260
106BMX0.40667245
107CASK0.40257842
108PRKCE0.39362465
109LATS20.39350686
110ATM0.39002622
111SIK30.38967310
112BMPR20.38613653
113CSNK1G10.38092420
114PNCK0.38057014
115STK390.38003925
116STK38L0.36966260
117TEC0.36201909
118EPHB20.36183646
119MAP3K50.36153127
120PRKCG0.35983027
121WNK40.35117271
122STK240.35035759
123WNK30.34677646
124EPHA20.34390746
125YES10.32551284
126IRAK40.32297951
127CDK20.30371716
128STK40.29554253
129NLK0.27757342
130LYN0.27747556
131TAOK20.27147305
132CDK11A0.27027657
133CDK140.26977000
134MAP2K30.26505560
135FLT30.26188294
136CDK180.26133499

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.96009884
2Proteasome_Homo sapiens_hsa030504.69014864
3RNA polymerase_Homo sapiens_hsa030204.15564414
4DNA replication_Homo sapiens_hsa030304.08631721
5Mismatch repair_Homo sapiens_hsa034303.58714040
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.16511311
7Pyrimidine metabolism_Homo sapiens_hsa002402.84418208
8Spliceosome_Homo sapiens_hsa030402.83856499
9Oxidative phosphorylation_Homo sapiens_hsa001902.77264188
10Nucleotide excision repair_Homo sapiens_hsa034202.77022979
11Homologous recombination_Homo sapiens_hsa034402.60510106
12Parkinsons disease_Homo sapiens_hsa050122.59672920
13Base excision repair_Homo sapiens_hsa034102.49615848
14Protein export_Homo sapiens_hsa030602.40079070
15RNA transport_Homo sapiens_hsa030132.35816114
16Basal transcription factors_Homo sapiens_hsa030222.25882878
17Huntingtons disease_Homo sapiens_hsa050162.13448017
18Cell cycle_Homo sapiens_hsa041102.08326382
19Fanconi anemia pathway_Homo sapiens_hsa034601.82765805
20* RNA degradation_Homo sapiens_hsa030181.76746964
21Non-homologous end-joining_Homo sapiens_hsa034501.65672501
22Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.63519509
23Alzheimers disease_Homo sapiens_hsa050101.63181154
24Fatty acid elongation_Homo sapiens_hsa000621.61734858
25Purine metabolism_Homo sapiens_hsa002301.59994545
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.59002961
27One carbon pool by folate_Homo sapiens_hsa006701.49878275
28Propanoate metabolism_Homo sapiens_hsa006401.38594107
29Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.37082927
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.30701658
31Sulfur metabolism_Homo sapiens_hsa009201.28073127
32Steroid biosynthesis_Homo sapiens_hsa001001.21649078
33p53 signaling pathway_Homo sapiens_hsa041151.17635367
34Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.14866389
35mRNA surveillance pathway_Homo sapiens_hsa030151.10272376
36Epstein-Barr virus infection_Homo sapiens_hsa051691.04531650
37Folate biosynthesis_Homo sapiens_hsa007901.04439753
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.96961417
39Peroxisome_Homo sapiens_hsa041460.96621613
40Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.85797498
41Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.84048362
42Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.79966854
43Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.79164808
44Oocyte meiosis_Homo sapiens_hsa041140.79008985
45Selenocompound metabolism_Homo sapiens_hsa004500.78317486
46Sulfur relay system_Homo sapiens_hsa041220.76537463
47Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.76080081
48Systemic lupus erythematosus_Homo sapiens_hsa053220.75233539
49Cysteine and methionine metabolism_Homo sapiens_hsa002700.74087131
50Butanoate metabolism_Homo sapiens_hsa006500.73454817
51Primary immunodeficiency_Homo sapiens_hsa053400.69490645
52Drug metabolism - other enzymes_Homo sapiens_hsa009830.66099633
53Glutathione metabolism_Homo sapiens_hsa004800.64426185
54Cardiac muscle contraction_Homo sapiens_hsa042600.63274455
55Herpes simplex infection_Homo sapiens_hsa051680.61204429
562-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.60260659
57Antigen processing and presentation_Homo sapiens_hsa046120.58710432
58Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.57017097
59Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.54744449
60Pentose and glucuronate interconversions_Homo sapiens_hsa000400.52322550
61Tryptophan metabolism_Homo sapiens_hsa003800.51852688
62Primary bile acid biosynthesis_Homo sapiens_hsa001200.51565851
63Metabolic pathways_Homo sapiens_hsa011000.51420092
64Pentose phosphate pathway_Homo sapiens_hsa000300.51403969
65Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.50987694
66Chemical carcinogenesis_Homo sapiens_hsa052040.50671207
67Asthma_Homo sapiens_hsa053100.49877864
68Nitrogen metabolism_Homo sapiens_hsa009100.49795486
69SNARE interactions in vesicular transport_Homo sapiens_hsa041300.47709998
70Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.45302060
71beta-Alanine metabolism_Homo sapiens_hsa004100.44216569
72N-Glycan biosynthesis_Homo sapiens_hsa005100.43009323
73Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.43004829
74Shigellosis_Homo sapiens_hsa051310.42920098
75Alcoholism_Homo sapiens_hsa050340.42806596
76Allograft rejection_Homo sapiens_hsa053300.42067754
77Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.41379133
78Viral carcinogenesis_Homo sapiens_hsa052030.40943056
79Retinol metabolism_Homo sapiens_hsa008300.36390360
80Hematopoietic cell lineage_Homo sapiens_hsa046400.34331412
81Thyroid cancer_Homo sapiens_hsa052160.33339625
82Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.32898682
83Biosynthesis of amino acids_Homo sapiens_hsa012300.32797396
84Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.32640901
85Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.32555059
86Regulation of autophagy_Homo sapiens_hsa041400.32511799
87Fatty acid metabolism_Homo sapiens_hsa012120.32367299
88Steroid hormone biosynthesis_Homo sapiens_hsa001400.31301903
89Fatty acid degradation_Homo sapiens_hsa000710.30825752
90Arachidonic acid metabolism_Homo sapiens_hsa005900.29814460
91Legionellosis_Homo sapiens_hsa051340.28856101
92Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.27255297
93Vibrio cholerae infection_Homo sapiens_hsa051100.27173920
94Vitamin B6 metabolism_Homo sapiens_hsa007500.26601886
95Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.25691016
96Caffeine metabolism_Homo sapiens_hsa002320.25642523
97HTLV-I infection_Homo sapiens_hsa051660.24782970
98Tyrosine metabolism_Homo sapiens_hsa003500.24496619
99RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.22916868
100Maturity onset diabetes of the young_Homo sapiens_hsa049500.20343760
101Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.20231775
102Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.20217862
103Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.19805097
104Autoimmune thyroid disease_Homo sapiens_hsa053200.19297006
105Measles_Homo sapiens_hsa051620.18957990
106Hepatitis B_Homo sapiens_hsa051610.17119432
107Collecting duct acid secretion_Homo sapiens_hsa049660.15906280
108Intestinal immune network for IgA production_Homo sapiens_hsa046720.15313833
109Pyruvate metabolism_Homo sapiens_hsa006200.14901075
110Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.14893760
111Apoptosis_Homo sapiens_hsa042100.14620245
112Carbon metabolism_Homo sapiens_hsa012000.13851001
113Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.11799361
114Other glycan degradation_Homo sapiens_hsa005110.11707663
115Linoleic acid metabolism_Homo sapiens_hsa005910.10734799
116Graft-versus-host disease_Homo sapiens_hsa053320.09628959
117Fructose and mannose metabolism_Homo sapiens_hsa000510.08187226
118Arginine and proline metabolism_Homo sapiens_hsa003300.07375956
119TGF-beta signaling pathway_Homo sapiens_hsa043500.05076744
120Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.04694974
121Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.04366877
122NF-kappa B signaling pathway_Homo sapiens_hsa040640.04122981
123Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.04108126
124Sphingolipid metabolism_Homo sapiens_hsa006000.03435053
125Phototransduction_Homo sapiens_hsa047440.03188898
126Rheumatoid arthritis_Homo sapiens_hsa053230.03102761
127Colorectal cancer_Homo sapiens_hsa052100.01694188
128Transcriptional misregulation in cancer_Homo sapiens_hsa052020.01346972
129Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.00884066
130Phagosome_Homo sapiens_hsa04145-0.0018982
131NOD-like receptor signaling pathway_Homo sapiens_hsa04621-0.0017097

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