

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | ribosomal small subunit assembly (GO:0000028) | 5.61763891 |
| 2 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 5.32489599 |
| 3 | DNA deamination (GO:0045006) | 5.09364801 |
| 4 | chaperone-mediated protein transport (GO:0072321) | 4.92055509 |
| 5 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 4.77129771 |
| 6 | ATP synthesis coupled proton transport (GO:0015986) | 4.68911763 |
| 7 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 4.68911763 |
| 8 | protein complex biogenesis (GO:0070271) | 4.54090765 |
| 9 | respiratory electron transport chain (GO:0022904) | 4.50839355 |
| 10 | electron transport chain (GO:0022900) | 4.39909964 |
| 11 | mitochondrial respiratory chain complex assembly (GO:0033108) | 4.27375985 |
| 12 | proteasome assembly (GO:0043248) | 4.24215532 |
| 13 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 4.20587800 |
| 14 | protein targeting to mitochondrion (GO:0006626) | 4.07648872 |
| 15 | viral transcription (GO:0019083) | 4.01226950 |
| 16 | ribosomal small subunit biogenesis (GO:0042274) | 3.90426602 |
| 17 | translational termination (GO:0006415) | 3.88124847 |
| 18 | establishment of protein localization to mitochondrion (GO:0072655) | 3.74261495 |
| 19 | telomere maintenance via semi-conservative replication (GO:0032201) | 3.73565521 |
| 20 | maturation of SSU-rRNA (GO:0030490) | 3.73501950 |
| 21 | regulation of mitochondrial translation (GO:0070129) | 3.67556927 |
| 22 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 3.67099625 |
| 23 | protein localization to mitochondrion (GO:0070585) | 3.62954278 |
| 24 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 3.59730085 |
| 25 | cotranslational protein targeting to membrane (GO:0006613) | 3.59699363 |
| 26 | oxidative phosphorylation (GO:0006119) | 3.57053344 |
| 27 | protein targeting to ER (GO:0045047) | 3.55242498 |
| 28 | translational elongation (GO:0006414) | 3.53514296 |
| 29 | telomere maintenance via recombination (GO:0000722) | 3.48692113 |
| 30 | protein maturation by protein folding (GO:0022417) | 3.45471403 |
| 31 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.42706942 |
| 32 | protein localization to endoplasmic reticulum (GO:0070972) | 3.42357233 |
| 33 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 3.39421313 |
| 34 | GTP biosynthetic process (GO:0006183) | 3.38059136 |
| 35 | platelet dense granule organization (GO:0060155) | 3.37888331 |
| 36 | DNA strand elongation involved in DNA replication (GO:0006271) | 3.37583880 |
| 37 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 3.32745958 |
| 38 | fatty acid elongation (GO:0030497) | 3.31090194 |
| 39 | DNA strand elongation (GO:0022616) | 3.30303088 |
| 40 | 7-methylguanosine mRNA capping (GO:0006370) | 3.29891083 |
| 41 | antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590) | 3.28748184 |
| 42 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.28355203 |
| 43 | termination of RNA polymerase III transcription (GO:0006386) | 3.28355203 |
| 44 | 7-methylguanosine RNA capping (GO:0009452) | 3.27898415 |
| 45 | RNA capping (GO:0036260) | 3.27898415 |
| 46 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.27315600 |
| 47 | pyrimidine deoxyribonucleotide metabolic process (GO:0009219) | 3.25579851 |
| 48 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.25033052 |
| 49 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.25033052 |
| 50 | base-excision repair, AP site formation (GO:0006285) | 3.22794290 |
| 51 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.22468996 |
| 52 | ribosomal large subunit biogenesis (GO:0042273) | 3.21669817 |
| 53 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.19973403 |
| 54 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.19973403 |
| 55 | ubiquinone biosynthetic process (GO:0006744) | 3.19237823 |
| 56 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.19221477 |
| 57 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.19163461 |
| 58 | formation of translation preinitiation complex (GO:0001731) | 3.18490946 |
| 59 | guanosine-containing compound biosynthetic process (GO:1901070) | 3.17564976 |
| 60 | viral life cycle (GO:0019058) | 3.17157973 |
| 61 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.16655726 |
| 62 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.16655726 |
| 63 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.16655726 |
| 64 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 3.15854649 |
| 65 | deoxyribonucleotide catabolic process (GO:0009264) | 3.15426275 |
| 66 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.14663544 |
| 67 | translational initiation (GO:0006413) | 3.12151385 |
| 68 | translation (GO:0006412) | 3.09533846 |
| 69 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.09193600 |
| 70 | negative regulation of ligase activity (GO:0051352) | 3.09193600 |
| 71 | peptidyl-histidine modification (GO:0018202) | 3.07965844 |
| 72 | deoxyribose phosphate catabolic process (GO:0046386) | 3.07647654 |
| 73 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.05686640 |
| 74 | nucleotide-excision repair, DNA gap filling (GO:0006297) | 3.04523898 |
| 75 | response to interferon-beta (GO:0035456) | 3.03635585 |
| 76 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.02796857 |
| 77 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.02796857 |
| 78 | regulation of cellular amine metabolic process (GO:0033238) | 3.01558093 |
| 79 | ribonucleoprotein complex biogenesis (GO:0022613) | 3.01185675 |
| 80 | maturation of 5.8S rRNA (GO:0000460) | 3.00615940 |
| 81 | DNA replication initiation (GO:0006270) | 3.00334330 |
| 82 | telomere maintenance via telomere lengthening (GO:0010833) | 3.00328541 |
| 83 | purine-containing compound salvage (GO:0043101) | 3.00139013 |
| 84 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.00027354 |
| 85 | mitochondrial transport (GO:0006839) | 2.99614284 |
| 86 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 2.99472899 |
| 87 | purine ribonucleoside triphosphate biosynthetic process (GO:0009206) | 2.98980360 |
| 88 | purine nucleoside triphosphate biosynthetic process (GO:0009145) | 2.98687892 |
| 89 | CENP-A containing nucleosome assembly (GO:0034080) | 2.98057461 |
| 90 | GMP metabolic process (GO:0046037) | 2.97284077 |
| 91 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 2.97153593 |
| 92 | pyrimidine nucleotide catabolic process (GO:0006244) | 2.95864558 |
| 93 | mitotic recombination (GO:0006312) | 2.95801524 |
| 94 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 2.94977944 |
| 95 | regulation of cellular amino acid metabolic process (GO:0006521) | 2.94082896 |
| 96 | cellular protein complex disassembly (GO:0043624) | 2.93950057 |
| 97 | ubiquinone metabolic process (GO:0006743) | 2.93802174 |
| 98 | pseudouridine synthesis (GO:0001522) | 2.91182272 |
| 99 | nucleobase biosynthetic process (GO:0046112) | 2.91165072 |
| 100 | rRNA modification (GO:0000154) | 2.90192839 |
| 101 | transcription-coupled nucleotide-excision repair (GO:0006283) | 2.90007407 |
| 102 | purine nucleobase biosynthetic process (GO:0009113) | 2.88715604 |
| 103 | ATP biosynthetic process (GO:0006754) | 2.86639694 |
| 104 | UTP biosynthetic process (GO:0006228) | 2.85933487 |
| 105 | regulation of ligase activity (GO:0051340) | 2.84934251 |
| 106 | chromatin remodeling at centromere (GO:0031055) | 2.84447590 |
| 107 | autophagic vacuole fusion (GO:0000046) | 2.83676173 |
| 108 | protein deneddylation (GO:0000338) | 2.82864600 |
| 109 | purine deoxyribonucleotide catabolic process (GO:0009155) | 2.82317641 |
| 110 | respiratory chain complex IV assembly (GO:0008535) | 2.81585436 |
| 111 | spliceosomal snRNP assembly (GO:0000387) | 2.81190901 |
| 112 | hydrogen ion transmembrane transport (GO:1902600) | 2.81042607 |
| 113 | 2-deoxyribonucleotide biosynthetic process (GO:0009265) | 2.80790135 |
| 114 | deoxyribose phosphate biosynthetic process (GO:0046385) | 2.80790135 |
| 115 | aerobic respiration (GO:0009060) | 2.78706706 |
| 116 | DNA replication checkpoint (GO:0000076) | 2.78607392 |
| 117 | DNA damage response, detection of DNA damage (GO:0042769) | 2.76598497 |
| 118 | establishment of integrated proviral latency (GO:0075713) | 2.76589534 |
| 119 | viral mRNA export from host cell nucleus (GO:0046784) | 2.74497829 |
| 120 | purine nucleotide salvage (GO:0032261) | 2.74425921 |
| 121 | 2-deoxyribonucleotide metabolic process (GO:0009394) | 2.73567934 |
| 122 | antigen processing and presentation of peptide antigen via MHC class I (GO:0002474) | 2.73258683 |
| 123 | pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148) | 2.73231704 |
| 124 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 2.72366884 |
| 125 | metallo-sulfur cluster assembly (GO:0031163) | 2.71153574 |
| 126 | iron-sulfur cluster assembly (GO:0016226) | 2.71153574 |
| 127 | cellular component biogenesis (GO:0044085) | 2.69862741 |
| 128 | rRNA processing (GO:0006364) | 2.68698412 |
| 129 | DNA damage response, signal transduction by p53 class mediator (GO:0030330) | 2.67770986 |
| 130 | positive regulation of ligase activity (GO:0051351) | 2.65315957 |
| 131 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 2.64200687 |
| 132 | NADH dehydrogenase complex assembly (GO:0010257) | 2.64200687 |
| 133 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 2.64200687 |
| 134 | regulation of antigen processing and presentation of peptide antigen (GO:0002583) | 2.63551256 |
| 135 | transcription from RNA polymerase I promoter (GO:0006360) | 2.63109063 |
| 136 | cullin deneddylation (GO:0010388) | 2.62235533 |
| 137 | DNA catabolic process, exonucleolytic (GO:0000738) | 2.61854462 |
| 138 | neutrophil activation involved in immune response (GO:0002283) | 2.60421049 |
| 139 | cytochrome complex assembly (GO:0017004) | 2.60289752 |
| 140 | protein neddylation (GO:0045116) | 2.59212988 |
| 141 | ribosome biogenesis (GO:0042254) | 2.58962686 |
| 142 | positive regulation of cell cycle arrest (GO:0071158) | 2.56409506 |
| 143 | transcription elongation from RNA polymerase II promoter (GO:0006368) | 2.56169464 |
| 144 | deoxyribonucleoside triphosphate metabolic process (GO:0009200) | 2.55676198 |
| 145 | termination of RNA polymerase I transcription (GO:0006363) | 2.55533950 |
| 146 | kinetochore assembly (GO:0051382) | 2.55499080 |
| 147 | transcription elongation from RNA polymerase I promoter (GO:0006362) | 2.54897237 |
| 148 | rRNA metabolic process (GO:0016072) | 2.54686760 |
| 149 | nuclear-transcribed mRNA catabolic process (GO:0000956) | 2.54568445 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E2F7_22180533_ChIP-Seq_HELA_Human | 4.50621962 |
| 2 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.02795902 |
| 3 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 3.86088013 |
| 4 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 3.54920876 |
| 5 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.50285585 |
| 6 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 3.45387928 |
| 7 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.43418420 |
| 8 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 3.01026916 |
| 9 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.97001376 |
| 10 | * ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.86387231 |
| 11 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.81121657 |
| 12 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.69962754 |
| 13 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.66036141 |
| 14 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 2.62822328 |
| 15 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 2.61211650 |
| 16 | * VDR_23849224_ChIP-Seq_CD4+_Human | 2.50420526 |
| 17 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.49393084 |
| 18 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.48455235 |
| 19 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.43958029 |
| 20 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 2.43308880 |
| 21 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 2.36001346 |
| 22 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.34390100 |
| 23 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 2.32779330 |
| 24 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 2.31614586 |
| 25 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 2.30449556 |
| 26 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.28946471 |
| 27 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.23975405 |
| 28 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 2.15435472 |
| 29 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 2.13827060 |
| 30 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.12466563 |
| 31 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.12263670 |
| 32 | XRN2_22483619_ChIP-Seq_HELA_Human | 2.10713806 |
| 33 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 2.10226435 |
| 34 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.08592338 |
| 35 | DCP1A_22483619_ChIP-Seq_HELA_Human | 2.06306728 |
| 36 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.00047606 |
| 37 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.96431379 |
| 38 | * FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.96076555 |
| 39 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.92687079 |
| 40 | * GABP_19822575_ChIP-Seq_HepG2_Human | 1.90909524 |
| 41 | * ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.84945539 |
| 42 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.83733710 |
| 43 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 1.78562872 |
| 44 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.73001413 |
| 45 | * SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.67494721 |
| 46 | * THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.64925869 |
| 47 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.63922234 |
| 48 | SPI1_23547873_ChIP-Seq_NB4_Human | 1.62489683 |
| 49 | * CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.57746005 |
| 50 | MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 1.54604463 |
| 51 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.54571665 |
| 52 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.53782329 |
| 53 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.51470160 |
| 54 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 1.46666151 |
| 55 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.44498669 |
| 56 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 1.42432091 |
| 57 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.41843343 |
| 58 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.38747324 |
| 59 | * POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.37726587 |
| 60 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 1.33782983 |
| 61 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.32471914 |
| 62 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.26610088 |
| 63 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.24911048 |
| 64 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.24756577 |
| 65 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.23782394 |
| 66 | MYB_21317192_ChIP-Seq_ERMYB_Mouse | 1.23268082 |
| 67 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.22988704 |
| 68 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.21854739 |
| 69 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.20009500 |
| 70 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.17512857 |
| 71 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 1.16867171 |
| 72 | * ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.15709716 |
| 73 | MEIS1_20887958_ChIP-Seq_HPC-7_Mouse | 1.15477938 |
| 74 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 1.14906415 |
| 75 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.12811444 |
| 76 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.12222694 |
| 77 | TFEB_21752829_ChIP-Seq_HELA_Human | 1.10135352 |
| 78 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.09970422 |
| 79 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.09865858 |
| 80 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 1.08846449 |
| 81 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.06415390 |
| 82 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 1.06395889 |
| 83 | YY1_22570637_ChIP-Seq_MALME-3M_Human | 1.06038914 |
| 84 | BCL6_27268052_Chip-Seq_Bcells_Human | 1.04407391 |
| 85 | * SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 1.03595366 |
| 86 | CTCF_18555785_ChIP-Seq_MESCs_Mouse | 1.02043703 |
| 87 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.99800822 |
| 88 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 0.99790794 |
| 89 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 0.98606553 |
| 90 | ELF1_20517297_ChIP-Seq_JURKAT_Human | 0.98377328 |
| 91 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 0.97448203 |
| 92 | SCL_19346495_ChIP-Seq_HPC-7_Human | 0.95522821 |
| 93 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 0.94532620 |
| 94 | * FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.93646072 |
| 95 | CIITA_25753668_ChIP-Seq_RAJI_Human | 0.93093086 |
| 96 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 0.92533757 |
| 97 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.92228674 |
| 98 | RBPJ_21746931_ChIP-Seq_IB4-LCL_Human | 0.91701344 |
| 99 | KDM5A_27292631_Chip-Seq_BREAST_Human | 0.91474196 |
| 100 | CTCF_26484167_Chip-Seq_Bcells_Mouse | 0.90283445 |
| 101 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 0.90218876 |
| 102 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 0.90011550 |
| 103 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 0.89915657 |
| 104 | GATA2_22383799_ChIP-Seq_G1ME_Mouse | 0.89914605 |
| 105 | MYB_26560356_Chip-Seq_TH2_Human | 0.89432542 |
| 106 | LMO2_20887958_ChIP-Seq_HPC-7_Mouse | 0.89186365 |
| 107 | GATA1_22383799_ChIP-Seq_G1ME_Mouse | 0.85796082 |
| 108 | TBX5_21415370_ChIP-Seq_HL-1_Mouse | 0.85222948 |
| 109 | PU.1_20513432_ChIP-Seq_Bcells_Mouse | 0.85029693 |
| 110 | FOXP1_21924763_ChIP-Seq_HESCs_Human | 0.84290055 |
| 111 | IRF8_27001747_Chip-Seq_BMDM_Mouse | 0.83740842 |
| 112 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 0.82518456 |
| 113 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 0.82225441 |
| 114 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 0.81447188 |
| 115 | STAT1_20625510_ChIP-Seq_HELA_Human | 0.80972201 |
| 116 | SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 0.80969020 |
| 117 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 0.80659864 |
| 118 | TP53_22573176_ChIP-Seq_HFKS_Human | 0.78342043 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003693_abnormal_embryo_hatching | 3.47699925 |
| 2 | MP0001835_abnormal_antigen_presentation | 3.46044903 |
| 3 | MP0009785_altered_susceptibility_to | 3.06792396 |
| 4 | MP0005671_abnormal_response_to | 2.69628415 |
| 5 | MP0008058_abnormal_DNA_repair | 2.67426225 |
| 6 | MP0003186_abnormal_redox_activity | 2.63370840 |
| 7 | MP0004957_abnormal_blastocyst_morpholog | 2.59975282 |
| 8 | MP0003077_abnormal_cell_cycle | 2.54502522 |
| 9 | MP0010094_abnormal_chromosome_stability | 2.53650707 |
| 10 | MP0002148_abnormal_hypersensitivity_rea | 2.52531309 |
| 11 | MP0000685_abnormal_immune_system | 2.46829350 |
| 12 | MP0003646_muscle_fatigue | 2.30029279 |
| 13 | MP0008007_abnormal_cellular_replicative | 2.28355306 |
| 14 | MP0008260_abnormal_autophagy | 2.23771575 |
| 15 | MP0005025_abnormal_response_to | 2.19574704 |
| 16 | MP0006082_CNS_inflammation | 2.18515350 |
| 17 | MP0003724_increased_susceptibility_to | 2.16063510 |
| 18 | MP0003436_decreased_susceptibility_to | 2.09533162 |
| 19 | MP0002132_abnormal_respiratory_system | 2.08126855 |
| 20 | MP0008057_abnormal_DNA_replication | 2.07734604 |
| 21 | MP0005000_abnormal_immune_tolerance | 2.06613863 |
| 22 | MP0001853_heart_inflammation | 2.05894604 |
| 23 | MP0003763_abnormal_thymus_physiology | 2.05021554 |
| 24 | MP0003806_abnormal_nucleotide_metabolis | 1.98459610 |
| 25 | MP0003111_abnormal_nucleus_morphology | 1.96658552 |
| 26 | MP0001529_abnormal_vocalization | 1.93764917 |
| 27 | MP0002396_abnormal_hematopoietic_system | 1.93649634 |
| 28 | MP0001800_abnormal_humoral_immune | 1.90352164 |
| 29 | MP0002452_abnormal_antigen_presenting | 1.89577311 |
| 30 | MP0002419_abnormal_innate_immunity | 1.88876043 |
| 31 | MP0009333_abnormal_splenocyte_physiolog | 1.86168164 |
| 32 | MP0002723_abnormal_immune_serum | 1.85247026 |
| 33 | MP0001819_abnormal_immune_cell | 1.83754596 |
| 34 | MP0002420_abnormal_adaptive_immunity | 1.83321698 |
| 35 | MP0002277_abnormal_respiratory_mucosa | 1.80027845 |
| 36 | MP0002837_dystrophic_cardiac_calcinosis | 1.77265218 |
| 37 | MP0002405_respiratory_system_inflammati | 1.75745456 |
| 38 | MP0002398_abnormal_bone_marrow | 1.74828554 |
| 39 | MP0009697_abnormal_copulation | 1.68499621 |
| 40 | MP0001790_abnormal_immune_system | 1.66129632 |
| 41 | MP0005387_immune_system_phenotype | 1.66129632 |
| 42 | MP0003718_maternal_effect | 1.63518354 |
| 43 | MP0003786_premature_aging | 1.63000131 |
| 44 | MP0001986_abnormal_taste_sensitivity | 1.62077082 |
| 45 | MP0001545_abnormal_hematopoietic_system | 1.57174988 |
| 46 | MP0005397_hematopoietic_system_phenotyp | 1.57174988 |
| 47 | MP0000689_abnormal_spleen_morphology | 1.56724229 |
| 48 | MP0000716_abnormal_immune_system | 1.55483451 |
| 49 | MP0002138_abnormal_hepatobiliary_system | 1.48870027 |
| 50 | MP0000343_altered_response_to | 1.48515383 |
| 51 | MP0000858_altered_metastatic_potential | 1.48399933 |
| 52 | MP0003011_delayed_dark_adaptation | 1.48013269 |
| 53 | MP0002722_abnormal_immune_system | 1.46178215 |
| 54 | MP0002429_abnormal_blood_cell | 1.45077753 |
| 55 | MP0006036_abnormal_mitochondrial_physio | 1.44202605 |
| 56 | MP0006054_spinal_hemorrhage | 1.43298345 |
| 57 | MP0009379_abnormal_foot_pigmentation | 1.41800430 |
| 58 | MP0005464_abnormal_platelet_physiology | 1.40297655 |
| 59 | MP0001764_abnormal_homeostasis | 1.37683803 |
| 60 | MP0002019_abnormal_tumor_incidence | 1.36506538 |
| 61 | MP0000490_abnormal_crypts_of | 1.36005896 |
| 62 | MP0002006_tumorigenesis | 1.33877649 |
| 63 | MP0008932_abnormal_embryonic_tissue | 1.33631967 |
| 64 | MP0004808_abnormal_hematopoietic_stem | 1.28863338 |
| 65 | MP0000372_irregular_coat_pigmentation | 1.27978211 |
| 66 | MP0000750_abnormal_muscle_regeneration | 1.26756638 |
| 67 | MP0003195_calcinosis | 1.26316665 |
| 68 | MP0001845_abnormal_inflammatory_respons | 1.26236485 |
| 69 | MP0008469_abnormal_protein_level | 1.25889064 |
| 70 | MP0005310_abnormal_salivary_gland | 1.24775436 |
| 71 | MP0000313_abnormal_cell_death | 1.22586289 |
| 72 | MP0004142_abnormal_muscle_tone | 1.18789738 |
| 73 | MP0001727_abnormal_embryo_implantation | 1.18378706 |
| 74 | MP0002736_abnormal_nociception_after | 1.18120922 |
| 75 | MP0006292_abnormal_olfactory_placode | 1.17028636 |
| 76 | MP0001873_stomach_inflammation | 1.07323741 |
| 77 | MP0004145_abnormal_muscle_electrophysio | 1.06978239 |
| 78 | MP0002166_altered_tumor_susceptibility | 1.06284799 |
| 79 | MP0000703_abnormal_thymus_morphology | 1.06140303 |
| 80 | MP0003656_abnormal_erythrocyte_physiolo | 1.03089855 |
| 81 | MP0001119_abnormal_female_reproductive | 1.02929910 |
| 82 | MP0010155_abnormal_intestine_physiology | 1.02824183 |
| 83 | MP0006035_abnormal_mitochondrial_morpho | 1.02351973 |
| 84 | MP0002163_abnormal_gland_morphology | 1.01788447 |
| 85 | MP0005332_abnormal_amino_acid | 1.00306915 |
| 86 | MP0001188_hyperpigmentation | 0.98709061 |
| 87 | MP0005075_abnormal_melanosome_morpholog | 0.98519894 |
| 88 | MP0000465_gastrointestinal_hemorrhage | 0.98437945 |
| 89 | MP0005379_endocrine/exocrine_gland_phen | 0.97826611 |
| 90 | MP0002095_abnormal_skin_pigmentation | 0.97434981 |
| 91 | MP0001348_abnormal_lacrimal_gland | 0.95748906 |
| 92 | MP0005166_decreased_susceptibility_to | 0.95612240 |
| 93 | MP0008873_increased_physiological_sensi | 0.94124642 |
| 94 | MP0008877_abnormal_DNA_methylation | 0.92692271 |
| 95 | MP0005636_abnormal_mineral_homeostasis | 0.88118373 |
| 96 | MP0005266_abnormal_metabolism | 0.88056267 |
| 97 | MP0005408_hypopigmentation | 0.87250190 |
| 98 | MP0005319_abnormal_enzyme/_coenzyme | 0.86899983 |
| 99 | MP0001533_abnormal_skeleton_physiology | 0.85527285 |
| 100 | MP0000749_muscle_degeneration | 0.83962637 |
| 101 | MP0004782_abnormal_surfactant_physiolog | 0.83394033 |
| 102 | MP0001968_abnormal_touch/_nociception | 0.83011814 |
| 103 | MP0000350_abnormal_cell_proliferation | 0.82851358 |
| 104 | MP0003448_altered_tumor_morphology | 0.82780036 |
| 105 | MP0005645_abnormal_hypothalamus_physiol | 0.78604499 |
| 106 | MP0002090_abnormal_vision | 0.75965068 |
| 107 | MP0009840_abnormal_foam_cell | 0.75434726 |
| 108 | MP0005376_homeostasis/metabolism_phenot | 0.75412330 |
| 109 | MP0005451_abnormal_body_composition | 0.73710675 |
| 110 | MP0008872_abnormal_physiological_respon | 0.73274965 |
| 111 | MP0006072_abnormal_retinal_apoptosis | 0.72410318 |
| 112 | MP0005058_abnormal_lysosome_morphology | 0.72267769 |
| 113 | MP0000358_abnormal_cell_content/ | 0.72048263 |
| 114 | MP0005410_abnormal_fertilization | 0.71672922 |
| 115 | MP0001851_eye_inflammation | 0.71544993 |
| 116 | MP0009764_decreased_sensitivity_to | 0.71460377 |
| 117 | MP0005551_abnormal_eye_electrophysiolog | 0.71416929 |
| 118 | MP0002933_joint_inflammation | 0.71320858 |
| 119 | MP0002332_abnormal_exercise_endurance | 0.71218796 |
| 120 | MP0001905_abnormal_dopamine_level | 0.71128367 |
| 121 | MP0005670_abnormal_white_adipose | 0.71095293 |
| 122 | MP0005389_reproductive_system_phenotype | 0.71026716 |
| 123 | MP0005584_abnormal_enzyme/coenzyme_acti | 0.70905589 |
| 124 | MP0003787_abnormal_imprinting | 0.70899393 |
| 125 | MP0003136_yellow_coat_color | 0.70639354 |
| 126 | MP0002653_abnormal_ependyma_morphology | 0.70638854 |
| 127 | MP0002102_abnormal_ear_morphology | 0.70360430 |
| 128 | MP0009763_increased_sensitivity_to | 0.70120514 |
| 129 | MP0008789_abnormal_olfactory_epithelium | 0.69850285 |
| 130 | MP0004947_skin_inflammation | 0.67781211 |
| 131 | MP0004147_increased_porphyrin_level | 0.67729973 |
| 132 | MP0005084_abnormal_gallbladder_morpholo | 0.66710331 |
| 133 | MP0002210_abnormal_sex_determination | 0.65857946 |
| 134 | MP0001730_embryonic_growth_arrest | 0.64570179 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Abnormality of cells of the erythroid lineage (HP:0012130) | 4.09288335 |
| 2 | Abnormal number of erythroid precursors (HP:0012131) | 4.08897404 |
| 3 | Aplastic anemia (HP:0001915) | 3.93533992 |
| 4 | Cerebral edema (HP:0002181) | 3.69486073 |
| 5 | Reticulocytopenia (HP:0001896) | 3.68595463 |
| 6 | Recurrent abscess formation (HP:0002722) | 3.63396531 |
| 7 | Birth length less than 3rd percentile (HP:0003561) | 3.55614268 |
| 8 | Acute necrotizing encephalopathy (HP:0006965) | 3.33056235 |
| 9 | Mitochondrial inheritance (HP:0001427) | 3.29328762 |
| 10 | Hepatocellular necrosis (HP:0001404) | 3.20066646 |
| 11 | Type I transferrin isoform profile (HP:0003642) | 3.19445759 |
| 12 | Recurrent bacterial skin infections (HP:0005406) | 3.17198573 |
| 13 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 3.05464032 |
| 14 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 3.05464032 |
| 15 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.05220079 |
| 16 | Hepatic necrosis (HP:0002605) | 3.04188722 |
| 17 | Increased CSF lactate (HP:0002490) | 2.98547150 |
| 18 | Increased hepatocellular lipid droplets (HP:0006565) | 2.96558208 |
| 19 | Myositis (HP:0100614) | 2.94500307 |
| 20 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 2.91106370 |
| 21 | 3-Methylglutaconic aciduria (HP:0003535) | 2.88639325 |
| 22 | Exertional dyspnea (HP:0002875) | 2.83416465 |
| 23 | Thrombocytosis (HP:0001894) | 2.81467525 |
| 24 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.75296836 |
| 25 | Lipid accumulation in hepatocytes (HP:0006561) | 2.74872333 |
| 26 | Elevated erythrocyte sedimentation rate (HP:0003565) | 2.74325607 |
| 27 | Muscle fiber atrophy (HP:0100295) | 2.69866028 |
| 28 | Renal Fanconi syndrome (HP:0001994) | 2.69484804 |
| 29 | Type 2 muscle fiber atrophy (HP:0003554) | 2.69193342 |
| 30 | Optic disc pallor (HP:0000543) | 2.63738386 |
| 31 | Poor head control (HP:0002421) | 2.63101222 |
| 32 | Progressive macrocephaly (HP:0004481) | 2.61531408 |
| 33 | Acute encephalopathy (HP:0006846) | 2.57764022 |
| 34 | Increased serum lactate (HP:0002151) | 2.56815932 |
| 35 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.56307324 |
| 36 | Cerebral hypomyelination (HP:0006808) | 2.54639323 |
| 37 | Microretrognathia (HP:0000308) | 2.52966013 |
| 38 | Oral leukoplakia (HP:0002745) | 2.52494044 |
| 39 | Breast hypoplasia (HP:0003187) | 2.51970231 |
| 40 | Macrocytic anemia (HP:0001972) | 2.51938725 |
| 41 | Reduced antithrombin III activity (HP:0001976) | 2.51437033 |
| 42 | Emotional lability (HP:0000712) | 2.49429181 |
| 43 | Pallor (HP:0000980) | 2.46722869 |
| 44 | Stomatitis (HP:0010280) | 2.44940363 |
| 45 | Pancytopenia (HP:0001876) | 2.44130532 |
| 46 | CNS demyelination (HP:0007305) | 2.42897639 |
| 47 | Abnormality of the heme biosynthetic pathway (HP:0010472) | 2.41938421 |
| 48 | Abnormality of macrophages (HP:0004311) | 2.41485194 |
| 49 | Lethargy (HP:0001254) | 2.40347678 |
| 50 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 2.40096037 |
| 51 | Retrobulbar optic neuritis (HP:0100654) | 2.36977043 |
| 52 | Optic neuritis (HP:0100653) | 2.36977043 |
| 53 | IgM deficiency (HP:0002850) | 2.36494559 |
| 54 | Eczematoid dermatitis (HP:0000976) | 2.35182457 |
| 55 | Leukodystrophy (HP:0002415) | 2.31356669 |
| 56 | Rough bone trabeculation (HP:0100670) | 2.30950152 |
| 57 | Petechiae (HP:0000967) | 2.30517201 |
| 58 | Abnormal protein glycosylation (HP:0012346) | 2.29715841 |
| 59 | Abnormal glycosylation (HP:0012345) | 2.29715841 |
| 60 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.29715841 |
| 61 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.29715841 |
| 62 | Microvesicular hepatic steatosis (HP:0001414) | 2.24823985 |
| 63 | Increased serum pyruvate (HP:0003542) | 2.24467913 |
| 64 | Abnormality of glycolysis (HP:0004366) | 2.24467913 |
| 65 | Vacuolated lymphocytes (HP:0001922) | 2.24375013 |
| 66 | Abnormality of the anterior horn cell (HP:0006802) | 2.24190761 |
| 67 | Degeneration of anterior horn cells (HP:0002398) | 2.24190761 |
| 68 | Orchitis (HP:0100796) | 2.23970078 |
| 69 | Pulmonary fibrosis (HP:0002206) | 2.22467460 |
| 70 | Increased intramyocellular lipid droplets (HP:0012240) | 2.22307884 |
| 71 | Respiratory difficulties (HP:0002880) | 2.22080080 |
| 72 | Progressive microcephaly (HP:0000253) | 2.21529681 |
| 73 | Autoimmune thrombocytopenia (HP:0001973) | 2.19331176 |
| 74 | Premature graying of hair (HP:0002216) | 2.18259133 |
| 75 | Abnormality of alanine metabolism (HP:0010916) | 2.17593684 |
| 76 | Hyperalaninemia (HP:0003348) | 2.17593684 |
| 77 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.17593684 |
| 78 | Generalized aminoaciduria (HP:0002909) | 2.16345989 |
| 79 | Lactic acidosis (HP:0003128) | 2.15138500 |
| 80 | Bone marrow hypocellularity (HP:0005528) | 2.14458985 |
| 81 | Nasal polyposis (HP:0100582) | 2.13307213 |
| 82 | Exercise intolerance (HP:0003546) | 2.11826037 |
| 83 | Abnormal pupillary function (HP:0007686) | 2.10872596 |
| 84 | Pancreatic cysts (HP:0001737) | 2.10342818 |
| 85 | Patellar aplasia (HP:0006443) | 2.10156134 |
| 86 | Mediastinal lymphadenopathy (HP:0100721) | 2.09636499 |
| 87 | Recurrent gram-negative bacterial infections (HP:0005420) | 2.07130246 |
| 88 | Increased IgM level (HP:0003496) | 2.05522409 |
| 89 | Abnormality of T cell number (HP:0011839) | 2.05050070 |
| 90 | 11 pairs of ribs (HP:0000878) | 2.04629120 |
| 91 | Secondary amenorrhea (HP:0000869) | 2.04130154 |
| 92 | IgG deficiency (HP:0004315) | 2.02843683 |
| 93 | Dicarboxylic aciduria (HP:0003215) | 2.01988690 |
| 94 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 2.01988690 |
| 95 | Hepatosplenomegaly (HP:0001433) | 2.01921397 |
| 96 | Lymphoma (HP:0002665) | 2.01790943 |
| 97 | Nausea (HP:0002018) | 2.01273345 |
| 98 | Myelodysplasia (HP:0002863) | 2.01008415 |
| 99 | Abnormality of aromatic amino acid family metabolism (HP:0004338) | 2.00905032 |
| 100 | Severe combined immunodeficiency (HP:0004430) | 2.00255474 |
| 101 | Abnormal trabecular bone morphology (HP:0100671) | 1.99481284 |
| 102 | Methylmalonic aciduria (HP:0012120) | 1.98997186 |
| 103 | Increased muscle lipid content (HP:0009058) | 1.97777404 |
| 104 | Carpal bone hypoplasia (HP:0001498) | 1.97090380 |
| 105 | Chronic obstructive pulmonary disease (HP:0006510) | 1.96311387 |
| 106 | Obstructive lung disease (HP:0006536) | 1.96311387 |
| 107 | Granulocytopenia (HP:0001913) | 1.95957261 |
| 108 | Respiratory failure (HP:0002878) | 1.93471773 |
| 109 | Abnormality of T cells (HP:0002843) | 1.93157940 |
| 110 | Abnormal spermatogenesis (HP:0008669) | 1.92848091 |
| 111 | Combined immunodeficiency (HP:0005387) | 1.92085671 |
| 112 | Cholecystitis (HP:0001082) | 1.90477952 |
| 113 | Abnormal gallbladder physiology (HP:0012438) | 1.90477952 |
| 114 | Rhabdomyolysis (HP:0003201) | 1.89167950 |
| 115 | Chromsome breakage (HP:0040012) | 1.88802653 |
| 116 | Hypergonadotropic hypogonadism (HP:0000815) | 1.88645539 |
| 117 | Cellular immunodeficiency (HP:0005374) | 1.88029781 |
| 118 | Abnormality of renal resorption (HP:0011038) | 1.87893426 |
| 119 | T lymphocytopenia (HP:0005403) | 1.87824095 |
| 120 | X-linked dominant inheritance (HP:0001423) | 1.86848944 |
| 121 | Recurrent skin infections (HP:0001581) | 1.86172597 |
| 122 | Aplasia/Hypoplasia of the patella (HP:0006498) | 1.85999266 |
| 123 | Abnormality of eosinophils (HP:0001879) | 1.85945625 |
| 124 | Glycosuria (HP:0003076) | 1.84901907 |
| 125 | Abnormality of urine glucose concentration (HP:0011016) | 1.84901907 |
| 126 | Cerebral palsy (HP:0100021) | 1.81956660 |
| 127 | Severe visual impairment (HP:0001141) | 1.81340215 |
| 128 | Delusions (HP:0000746) | 1.80154039 |
| 129 | Ragged-red muscle fibers (HP:0003200) | 1.78939639 |
| 130 | Nemaline bodies (HP:0003798) | 1.78561032 |
| 131 | Gliosis (HP:0002171) | 1.78382833 |
| 132 | Increased serum ferritin (HP:0003281) | 1.78178280 |
| 133 | Paralysis (HP:0003470) | 1.76023046 |
| 134 | Constricted visual fields (HP:0001133) | 1.75559426 |
| 135 | Hypokinesia (HP:0002375) | 1.69668496 |
| 136 | Muscle fiber inclusion bodies (HP:0100299) | 1.66793207 |
| 137 | Opisthotonus (HP:0002179) | 1.65587542 |
| 138 | Neutropenia (HP:0001875) | 1.64782913 |
| 139 | Congenital stationary night blindness (HP:0007642) | 1.63360484 |
| 140 | Myopathic facies (HP:0002058) | 1.62644166 |
| 141 | Methylmalonic acidemia (HP:0002912) | 1.60561907 |
| 142 | Muscle fiber cytoplasmatic inclusion bodies (HP:0100303) | 1.60230886 |
| 143 | Blindness (HP:0000618) | 1.59881401 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | NME2 | 3.84467278 |
| 2 | STK16 | 3.45952856 |
| 3 | VRK2 | 3.11613195 |
| 4 | EIF2AK1 | 2.92041434 |
| 5 | PIM2 | 2.83954651 |
| 6 | BUB1 | 2.62075013 |
| 7 | TRIM28 | 2.49709401 |
| 8 | EIF2AK3 | 2.45557345 |
| 9 | VRK1 | 2.36897975 |
| 10 | WEE1 | 2.21621238 |
| 11 | SRPK1 | 2.10842948 |
| 12 | PLK4 | 1.98383215 |
| 13 | MUSK | 1.96515658 |
| 14 | ACVR1B | 1.88517813 |
| 15 | MAP4K1 | 1.87949830 |
| 16 | KIT | 1.82514036 |
| 17 | TXK | 1.75886626 |
| 18 | PDK2 | 1.73503570 |
| 19 | MAP3K12 | 1.73334448 |
| 20 | TLK1 | 1.72853946 |
| 21 | TEC | 1.65254097 |
| 22 | PBK | 1.57564528 |
| 23 | ARAF | 1.50773877 |
| 24 | IKBKB | 1.48463047 |
| 25 | TYK2 | 1.45519973 |
| 26 | TBK1 | 1.43702940 |
| 27 | MST4 | 1.40872269 |
| 28 | IRAK4 | 1.40375589 |
| 29 | KDR | 1.39536132 |
| 30 | MYLK | 1.39510683 |
| 31 | FLT3 | 1.37767709 |
| 32 | IKBKE | 1.35008550 |
| 33 | CDC7 | 1.32635485 |
| 34 | MARK3 | 1.28536636 |
| 35 | DAPK1 | 1.28446719 |
| 36 | MAP3K14 | 1.27514039 |
| 37 | JAK3 | 1.26129600 |
| 38 | PIM1 | 1.26024470 |
| 39 | BCKDK | 1.25726008 |
| 40 | RPS6KA4 | 1.25028171 |
| 41 | NEK1 | 1.23688771 |
| 42 | EIF2AK2 | 1.21903141 |
| 43 | BTK | 1.20961134 |
| 44 | MKNK1 | 1.20018233 |
| 45 | MAP4K2 | 1.19502729 |
| 46 | BMPR1B | 1.18206266 |
| 47 | BLK | 1.17493119 |
| 48 | NUAK1 | 1.12348081 |
| 49 | CDK8 | 1.11675871 |
| 50 | BRAF | 1.09278086 |
| 51 | FES | 1.06797675 |
| 52 | OBSCN | 1.06655858 |
| 53 | LIMK1 | 1.06635284 |
| 54 | ZAP70 | 1.03005885 |
| 55 | TAF1 | 1.01115983 |
| 56 | IRAK3 | 1.01055326 |
| 57 | TESK2 | 1.00784504 |
| 58 | PLK1 | 0.99719191 |
| 59 | TGFBR1 | 0.97356013 |
| 60 | TSSK6 | 0.97078499 |
| 61 | ZAK | 0.96871355 |
| 62 | GRK7 | 0.96766788 |
| 63 | PINK1 | 0.96641016 |
| 64 | BRSK2 | 0.94644592 |
| 65 | CSNK1G3 | 0.93391062 |
| 66 | DYRK3 | 0.92927848 |
| 67 | TAOK3 | 0.92893252 |
| 68 | AURKB | 0.92564370 |
| 69 | CDK7 | 0.92030254 |
| 70 | SIK3 | 0.91284754 |
| 71 | STK10 | 0.90868513 |
| 72 | PIK3CG | 0.90678903 |
| 73 | DYRK2 | 0.89349982 |
| 74 | ABL2 | 0.89123553 |
| 75 | ADRBK2 | 0.87905660 |
| 76 | ATR | 0.86130972 |
| 77 | CSF1R | 0.86075908 |
| 78 | MAPKAPK3 | 0.85084844 |
| 79 | MAP2K3 | 0.84758212 |
| 80 | PAK1 | 0.83762349 |
| 81 | MKNK2 | 0.83320466 |
| 82 | BMPR2 | 0.82592668 |
| 83 | SYK | 0.80673242 |
| 84 | STK4 | 0.80144173 |
| 85 | PRKCI | 0.80010508 |
| 86 | CHUK | 0.78616664 |
| 87 | LYN | 0.78090471 |
| 88 | WNK3 | 0.77942425 |
| 89 | NLK | 0.76980388 |
| 90 | STK38L | 0.76734414 |
| 91 | TNK2 | 0.75467560 |
| 92 | ILK | 0.75127396 |
| 93 | GRK1 | 0.74200756 |
| 94 | GRK6 | 0.72604944 |
| 95 | NEK2 | 0.71502076 |
| 96 | NEK9 | 0.71452493 |
| 97 | RPS6KA5 | 0.71218407 |
| 98 | PHKG2 | 0.69779841 |
| 99 | PHKG1 | 0.69779841 |
| 100 | PASK | 0.69327451 |
| 101 | CCNB1 | 0.69326711 |
| 102 | TAOK2 | 0.68851891 |
| 103 | PAK4 | 0.68768595 |
| 104 | CSNK1G2 | 0.67049493 |
| 105 | CSNK2A1 | 0.66066661 |
| 106 | RAF1 | 0.66031050 |
| 107 | TESK1 | 0.65593246 |
| 108 | TGFBR2 | 0.64728100 |
| 109 | SCYL2 | 0.64373095 |
| 110 | CSNK1G1 | 0.64064216 |
| 111 | AURKA | 0.63796224 |
| 112 | MAP3K11 | 0.63587653 |
| 113 | RPS6KB2 | 0.58629641 |
| 114 | TTK | 0.56650483 |
| 115 | LCK | 0.55825534 |
| 116 | PRKCQ | 0.55127166 |
| 117 | STK24 | 0.54632425 |
| 118 | RIPK4 | 0.54499105 |
| 119 | LRRK2 | 0.54356460 |
| 120 | MATK | 0.54083060 |
| 121 | PLK3 | 0.53656472 |
| 122 | MOS | 0.52681462 |
| 123 | MAP3K8 | 0.47962725 |
| 124 | YES1 | 0.46985025 |
| 125 | BRSK1 | 0.44848612 |
| 126 | CAMK2G | 0.44604068 |
| 127 | CSNK1A1L | 0.43774207 |
| 128 | MAP3K13 | 0.43452266 |
| 129 | CSNK2A2 | 0.42489445 |
| 130 | NME1 | 0.41757401 |
| 131 | CDK19 | 0.41724883 |
| 132 | MAPKAPK5 | 0.41374528 |
| 133 | PRKCD | 0.41345153 |
| 134 | CDK4 | 0.40703079 |
| 135 | TAOK1 | 0.40636571 |
| 136 | MAP3K5 | 0.39338733 |
| 137 | MAPKAPK2 | 0.39282556 |
| 138 | TRPM7 | 0.39234614 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Ribosome_Homo sapiens_hsa03010 | 4.21548967 |
| 2 | Proteasome_Homo sapiens_hsa03050 | 3.89272102 |
| 3 | DNA replication_Homo sapiens_hsa03030 | 3.72951760 |
| 4 | RNA polymerase_Homo sapiens_hsa03020 | 3.45333789 |
| 5 | Mismatch repair_Homo sapiens_hsa03430 | 2.90089200 |
| 6 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 2.48014676 |
| 7 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.47997705 |
| 8 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 2.44159627 |
| 9 | Homologous recombination_Homo sapiens_hsa03440 | 2.44145834 |
| 10 | Base excision repair_Homo sapiens_hsa03410 | 2.35371605 |
| 11 | Protein export_Homo sapiens_hsa03060 | 2.26581675 |
| 12 | Spliceosome_Homo sapiens_hsa03040 | 2.21337125 |
| 13 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.17820115 |
| 14 | Basal transcription factors_Homo sapiens_hsa03022 | 2.08525863 |
| 15 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 1.90100302 |
| 16 | RNA degradation_Homo sapiens_hsa03018 | 1.87789367 |
| 17 | Parkinsons disease_Homo sapiens_hsa05012 | 1.86586605 |
| 18 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.79607169 |
| 19 | RNA transport_Homo sapiens_hsa03013 | 1.69840769 |
| 20 | Allograft rejection_Homo sapiens_hsa05330 | 1.68187176 |
| 21 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.57833390 |
| 22 | Graft-versus-host disease_Homo sapiens_hsa05332 | 1.55451588 |
| 23 | Huntingtons disease_Homo sapiens_hsa05016 | 1.48776556 |
| 24 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.46970554 |
| 25 | Cell cycle_Homo sapiens_hsa04110 | 1.46438516 |
| 26 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.43054606 |
| 27 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 1.40284278 |
| 28 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.40055822 |
| 29 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.39544136 |
| 30 | Purine metabolism_Homo sapiens_hsa00230 | 1.35195144 |
| 31 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.32456639 |
| 32 | Primary immunodeficiency_Homo sapiens_hsa05340 | 1.25685474 |
| 33 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.25332667 |
| 34 | Herpes simplex infection_Homo sapiens_hsa05168 | 1.18528294 |
| 35 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.15413911 |
| 36 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 1.15305934 |
| 37 | Asthma_Homo sapiens_hsa05310 | 1.14041124 |
| 38 | Legionellosis_Homo sapiens_hsa05134 | 1.12605507 |
| 39 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 1.11944555 |
| 40 | p53 signaling pathway_Homo sapiens_hsa04115 | 1.11919208 |
| 41 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.10247316 |
| 42 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.08909836 |
| 43 | Antigen processing and presentation_Homo sapiens_hsa04612 | 1.08000975 |
| 44 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 1.07572681 |
| 45 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 1.05970848 |
| 46 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 1.05819723 |
| 47 | Measles_Homo sapiens_hsa05162 | 1.04999264 |
| 48 | Alzheimers disease_Homo sapiens_hsa05010 | 1.00742283 |
| 49 | Leishmaniasis_Homo sapiens_hsa05140 | 1.00561077 |
| 50 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 1.00169222 |
| 51 | Carbon metabolism_Homo sapiens_hsa01200 | 0.97118431 |
| 52 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.96014170 |
| 53 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.94680533 |
| 54 | Other glycan degradation_Homo sapiens_hsa00511 | 0.92314075 |
| 55 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.90727693 |
| 56 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.90196396 |
| 57 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.88849983 |
| 58 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 0.87900573 |
| 59 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.87222470 |
| 60 | Viral myocarditis_Homo sapiens_hsa05416 | 0.86865520 |
| 61 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.86303786 |
| 62 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.86222217 |
| 63 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.85229184 |
| 64 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.74922331 |
| 65 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.74733039 |
| 66 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.74460566 |
| 67 | Malaria_Homo sapiens_hsa05144 | 0.72570244 |
| 68 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.72461765 |
| 69 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.71208444 |
| 70 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.70887087 |
| 71 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.69743920 |
| 72 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.66196109 |
| 73 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.63730415 |
| 74 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.62774986 |
| 75 | Apoptosis_Homo sapiens_hsa04210 | 0.62373328 |
| 76 | Phototransduction_Homo sapiens_hsa04744 | 0.61764900 |
| 77 | Influenza A_Homo sapiens_hsa05164 | 0.61209890 |
| 78 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.60562596 |
| 79 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.59277698 |
| 80 | Shigellosis_Homo sapiens_hsa05131 | 0.58018629 |
| 81 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 0.54794070 |
| 82 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 0.53782669 |
| 83 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.51104097 |
| 84 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.51031874 |
| 85 | Pertussis_Homo sapiens_hsa05133 | 0.50192667 |
| 86 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.50158151 |
| 87 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.49458715 |
| 88 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 0.48789074 |
| 89 | Metabolic pathways_Homo sapiens_hsa01100 | 0.46884280 |
| 90 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.46295933 |
| 91 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.45574351 |
| 92 | Hepatitis B_Homo sapiens_hsa05161 | 0.43040191 |
| 93 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.42257836 |
| 94 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.41417422 |
| 95 | Sulfur relay system_Homo sapiens_hsa04122 | 0.40563817 |
| 96 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.40492978 |
| 97 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.38417613 |
| 98 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.36370337 |
| 99 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 0.35765720 |
| 100 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.35108433 |
| 101 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.35011423 |
| 102 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.34599184 |
| 103 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.34428619 |
| 104 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.33956083 |
| 105 | Lysosome_Homo sapiens_hsa04142 | 0.32470061 |
| 106 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.30563109 |
| 107 | Phagosome_Homo sapiens_hsa04145 | 0.29211712 |
| 108 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.28711431 |
| 109 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.28383054 |
| 110 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.28155665 |
| 111 | Peroxisome_Homo sapiens_hsa04146 | 0.27699918 |
| 112 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.27674939 |
| 113 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 0.27551426 |
| 114 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.27423998 |
| 115 | HTLV-I infection_Homo sapiens_hsa05166 | 0.27322832 |
| 116 | Tuberculosis_Homo sapiens_hsa05152 | 0.26934309 |
| 117 | TNF signaling pathway_Homo sapiens_hsa04668 | 0.26270095 |
| 118 | Thyroid cancer_Homo sapiens_hsa05216 | 0.25917693 |
| 119 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.25853882 |
| 120 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.25344437 |
| 121 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.23967747 |
| 122 | Galactose metabolism_Homo sapiens_hsa00052 | 0.23594349 |
| 123 | Osteoclast differentiation_Homo sapiens_hsa04380 | 0.21490733 |
| 124 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.21469749 |
| 125 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.20674997 |
| 126 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.19954613 |
| 127 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 0.18739014 |
| 128 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.18402583 |
| 129 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.18080973 |

