LSM12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit biogenesis (GO:0042274)5.87537053
2viral transcription (GO:0019083)5.53063260
3translational termination (GO:0006415)5.39232822
4maturation of SSU-rRNA (GO:0030490)5.35733458
5ribosomal small subunit assembly (GO:0000028)5.30696870
6ribosomal large subunit biogenesis (GO:0042273)4.92066629
7proteasome assembly (GO:0043248)4.85618057
8SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.51247935
9cotranslational protein targeting to membrane (GO:0006613)4.49126528
10translational initiation (GO:0006413)4.44056826
11protein targeting to ER (GO:0045047)4.43688461
12translational elongation (GO:0006414)4.41154147
13cellular protein complex disassembly (GO:0043624)4.33181206
14nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.28252370
15establishment of protein localization to endoplasmic reticulum (GO:0072599)4.22291069
16protein localization to endoplasmic reticulum (GO:0070972)4.19025916
17ribosome assembly (GO:0042255)4.15929362
18ribonucleoprotein complex biogenesis (GO:0022613)4.14840364
19viral life cycle (GO:0019058)4.13501130
20respiratory chain complex IV assembly (GO:0008535)3.98004803
21lactate metabolic process (GO:0006089)3.85632128
22protein complex disassembly (GO:0043241)3.84455781
23negative regulation of DNA-dependent DNA replication (GO:2000104)3.80413748
24rRNA processing (GO:0006364)3.74251440
25protein deneddylation (GO:0000338)3.68652914
26histone exchange (GO:0043486)3.66841319
27kinetochore organization (GO:0051383)3.66181550
28spliceosomal snRNP assembly (GO:0000387)3.66064607
29establishment of protein localization to mitochondrial membrane (GO:0090151)3.65670575
30translation (GO:0006412)3.64162062
31protein neddylation (GO:0045116)3.63276344
32macromolecular complex disassembly (GO:0032984)3.60433154
33rRNA metabolic process (GO:0016072)3.59655579
34kinetochore assembly (GO:0051382)3.59597231
35mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.59493469
36water-soluble vitamin biosynthetic process (GO:0042364)3.59156755
37establishment of integrated proviral latency (GO:0075713)3.58861347
38termination of RNA polymerase III transcription (GO:0006386)3.54869971
39transcription elongation from RNA polymerase III promoter (GO:0006385)3.54869971
40IMP biosynthetic process (GO:0006188)3.51789665
41DNA ligation (GO:0006266)3.51520913
42regulation of cellular amino acid metabolic process (GO:0006521)3.51061377
43replication fork processing (GO:0031297)3.49799891
44regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.47840103
45regulation of mitotic spindle checkpoint (GO:1903504)3.47840103
46telomere maintenance via semi-conservative replication (GO:0032201)3.46038821
47cytochrome complex assembly (GO:0017004)3.43666914
48microtubule depolymerization (GO:0007019)3.42222845
49ATP synthesis coupled proton transport (GO:0015986)3.41816731
50energy coupled proton transport, down electrochemical gradient (GO:0015985)3.41816731
517-methylguanosine RNA capping (GO:0009452)3.40023058
52RNA capping (GO:0036260)3.40023058
53spliceosomal complex assembly (GO:0000245)3.39656780
54DNA replication initiation (GO:0006270)3.39622317
557-methylguanosine mRNA capping (GO:0006370)3.39245626
56nucleobase biosynthetic process (GO:0046112)3.38019421
57rRNA methylation (GO:0031167)3.37991586
58DNA catabolic process, exonucleolytic (GO:0000738)3.36281445
59cellular component biogenesis (GO:0044085)3.35634977
60transcription elongation from RNA polymerase I promoter (GO:0006362)3.35433202
61nuclear-transcribed mRNA catabolic process (GO:0000956)3.32911831
62DNA strand elongation involved in DNA replication (GO:0006271)3.30351896
63DNA damage response, detection of DNA damage (GO:0042769)3.29407518
64somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.29124985
65isotype switching (GO:0045190)3.29124985
66somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.29124985
67formation of translation preinitiation complex (GO:0001731)3.23640605
68CENP-A containing nucleosome assembly (GO:0034080)3.21959460
69regulation of nuclear cell cycle DNA replication (GO:0033262)3.20885382
70synapsis (GO:0007129)3.19690068
71chromatin remodeling at centromere (GO:0031055)3.19550478
72transcription from RNA polymerase I promoter (GO:0006360)3.19537495
73mRNA catabolic process (GO:0006402)3.19319265
74positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.19092141
75termination of RNA polymerase I transcription (GO:0006363)3.18977365
76telomere maintenance via recombination (GO:0000722)3.18119413
77ribosome biogenesis (GO:0042254)3.17946301
78somatic hypermutation of immunoglobulin genes (GO:0016446)3.16072014
79somatic diversification of immune receptors via somatic mutation (GO:0002566)3.16072014
80protein complex biogenesis (GO:0070271)3.15745872
81metaphase plate congression (GO:0051310)3.15307913
82DNA replication checkpoint (GO:0000076)3.15272837
83DNA strand elongation (GO:0022616)3.15094218
84negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.14137921
85mitochondrial respiratory chain complex assembly (GO:0033108)3.13910079
86spindle checkpoint (GO:0031577)3.13666353
87nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.11648180
88exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.11009684
89positive regulation of ligase activity (GO:0051351)3.06784511
90RNA catabolic process (GO:0006401)3.06048265
91transcription-coupled nucleotide-excision repair (GO:0006283)3.05335303
92protein K6-linked ubiquitination (GO:0085020)3.04857746
93RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.04099622
94chaperone-mediated protein transport (GO:0072321)3.01164869
95non-recombinational repair (GO:0000726)2.98910369
96double-strand break repair via nonhomologous end joining (GO:0006303)2.98910369
97mitotic recombination (GO:0006312)2.98366623
98regulation of ubiquitin-protein transferase activity (GO:0051438)2.97494407
99DNA deamination (GO:0045006)2.97138579
100telomere maintenance via telomerase (GO:0007004)2.96792870
101regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.96626805
102positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.95429991
103mitotic spindle checkpoint (GO:0071174)2.94990140
104GTP biosynthetic process (GO:0006183)2.94578245
105DNA double-strand break processing (GO:0000729)2.94475665
106mitotic metaphase plate congression (GO:0007080)2.94393337
107anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.94149615
108regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.93704238
109negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.93671606
110negative regulation of ligase activity (GO:0051352)2.93671606
111mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.92672240
112mitochondrial respiratory chain complex I assembly (GO:0032981)2.92672240
113NADH dehydrogenase complex assembly (GO:0010257)2.92672240
114maturation of 5.8S rRNA (GO:0000460)2.91747620
115IMP metabolic process (GO:0046040)2.91248511
116DNA strand renaturation (GO:0000733)2.90702273
117response to X-ray (GO:0010165)2.90329520
118DNA replication-independent nucleosome organization (GO:0034724)2.89965141
119DNA replication-independent nucleosome assembly (GO:0006336)2.89965141
120establishment of viral latency (GO:0019043)2.89694572
121regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.88778958
122peptidyl-histidine modification (GO:0018202)2.88167428
123maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.88084382
124regulation of ligase activity (GO:0051340)2.88036410
125protein localization to kinetochore (GO:0034501)2.87969983
126rRNA modification (GO:0000154)2.87407438
127DNA replication-dependent nucleosome organization (GO:0034723)2.86396240
128DNA replication-dependent nucleosome assembly (GO:0006335)2.86396240
129nucleotide-excision repair, DNA gap filling (GO:0006297)2.86100691
130UTP biosynthetic process (GO:0006228)2.85684667
131platelet dense granule organization (GO:0060155)2.84806079
132histone H2A acetylation (GO:0043968)2.84184331
133DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.84057523
134pseudouridine synthesis (GO:0001522)2.83859531
135regulation of helicase activity (GO:0051095)2.83836753
136protein targeting to membrane (GO:0006612)2.83108051
137transcription initiation from RNA polymerase I promoter (GO:0006361)2.81991030
138positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)2.81745154
139telomere maintenance via telomere lengthening (GO:0010833)2.80286236
140signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.78011361
141intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.78011361
142signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.77665364
143signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.77665364
144signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.77665364
145attachment of spindle microtubules to kinetochore (GO:0008608)2.77242370
146recombinational repair (GO:0000725)2.77126260
147pteridine-containing compound biosynthetic process (GO:0042559)2.75699075
148purine nucleobase biosynthetic process (GO:0009113)2.75220049
149transcription elongation from RNA polymerase II promoter (GO:0006368)2.74673634
150signal transduction involved in DNA damage checkpoint (GO:0072422)2.74435421
151signal transduction involved in DNA integrity checkpoint (GO:0072401)2.74435421
152signal transduction involved in cell cycle checkpoint (GO:0072395)2.73609046
153regulation of double-strand break repair via homologous recombination (GO:0010569)2.72756728
154DNA-templated transcription, termination (GO:0006353)2.72637979
155cullin deneddylation (GO:0010388)2.70145125
156RNA splicing, via transesterification reactions (GO:0000375)2.70069192

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.13962841
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.54900027
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.43681141
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.12181466
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.86911181
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.71285283
7E2F4_17652178_ChIP-ChIP_JURKAT_Human3.62951445
8GABP_17652178_ChIP-ChIP_JURKAT_Human3.57851215
9* CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.24098668
10MYC_19079543_ChIP-ChIP_MESCs_Mouse3.18130665
11CREB1_15753290_ChIP-ChIP_HEK293T_Human3.15650987
12ETS1_20019798_ChIP-Seq_JURKAT_Human3.14775606
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.04064124
14* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.95078800
15FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.86332355
16MYC_18358816_ChIP-ChIP_MESCs_Mouse2.85928245
17HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.79870654
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.69593741
19HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.69497859
20NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.68592023
21FOXM1_23109430_ChIP-Seq_U2OS_Human2.66078934
22* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.63112890
23ELK1_19687146_ChIP-ChIP_HELA_Human2.50018474
24ZNF274_21170338_ChIP-Seq_K562_Hela2.46847866
25VDR_23849224_ChIP-Seq_CD4+_Human2.46489263
26CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.41466704
27ELF1_17652178_ChIP-ChIP_JURKAT_Human2.38977854
28XRN2_22483619_ChIP-Seq_HELA_Human2.38249019
29MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.23629633
30TP63_19390658_ChIP-ChIP_HaCaT_Human2.21346950
31VDR_22108803_ChIP-Seq_LS180_Human2.21048868
32NELFA_20434984_ChIP-Seq_ESCs_Mouse2.20969079
33TTF2_22483619_ChIP-Seq_HELA_Human2.17649040
34DCP1A_22483619_ChIP-Seq_HELA_Human2.05139671
35POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.03531832
36MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.99846207
37FOXP3_21729870_ChIP-Seq_TREG_Human1.96844689
38* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.90640351
39IRF1_19129219_ChIP-ChIP_H3396_Human1.90432946
40THAP11_20581084_ChIP-Seq_MESCs_Mouse1.89716246
41MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.88132577
42NANOG_18555785_ChIP-Seq_MESCs_Mouse1.86144540
43YY1_21170310_ChIP-Seq_MESCs_Mouse1.84497297
44ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.78357777
45POU5F1_16153702_ChIP-ChIP_HESCs_Human1.77403927
46POU3F2_20337985_ChIP-ChIP_501MEL_Human1.75501854
47KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.71268225
48KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.71268225
49KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.71268225
50POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.70188444
51YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.60560404
52GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.59493090
53* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.58205618
54MYCN_18555785_ChIP-Seq_MESCs_Mouse1.56678449
55ELK1_22589737_ChIP-Seq_MCF10A_Human1.52810059
56P300_19829295_ChIP-Seq_ESCs_Human1.52043607
57* GABP_19822575_ChIP-Seq_HepG2_Human1.49097037
58HOXB4_20404135_ChIP-ChIP_EML_Mouse1.46277248
59PCGF2_27294783_Chip-Seq_ESCs_Mouse1.43512238
60ZFP57_27257070_Chip-Seq_ESCs_Mouse1.43147272
61* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.42898605
62FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.38216642
63SOX2_18555785_ChIP-Seq_MESCs_Mouse1.37999645
64E2F1_21310950_ChIP-Seq_MCF-7_Human1.35084334
65SRF_21415370_ChIP-Seq_HL-1_Mouse1.33076585
66PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.32966748
67SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.30653596
68ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.30216886
69MYC_18940864_ChIP-ChIP_HL60_Human1.30006745
70CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.29516233
71IGF1R_20145208_ChIP-Seq_DFB_Human1.27973298
72PADI4_21655091_ChIP-ChIP_MCF-7_Human1.24940089
73SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.24750540
74* AR_21909140_ChIP-Seq_LNCAP_Human1.18483255
75GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18287863
76TAF15_26573619_Chip-Seq_HEK293_Human1.18193722
77TCF3_18692474_ChIP-Seq_MEFs_Mouse1.17863128
78NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.17742740
79CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.16536039
80SOX2_16153702_ChIP-ChIP_HESCs_Human1.13679336
81TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.13423935
82EZH2_27294783_Chip-Seq_NPCs_Mouse1.13012656
83HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.08175030
84GBX2_23144817_ChIP-Seq_PC3_Human1.08099962
85EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.07656129
86KDM5A_27292631_Chip-Seq_BREAST_Human1.07520662
87RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.05314483
88NOTCH1_21737748_ChIP-Seq_TLL_Human1.05024475
89FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.04670648
90NFE2_27457419_Chip-Seq_LIVER_Mouse1.04627479
91SUZ12_27294783_Chip-Seq_NPCs_Mouse1.04623977
92CTBP2_25329375_ChIP-Seq_LNCAP_Human1.04519002
93AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.02548403
94PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.01683625
95SOX2_19829295_ChIP-Seq_ESCs_Human1.01334883
96NANOG_19829295_ChIP-Seq_ESCs_Human1.01334883
97GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.99058284
98* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.97220706
99NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.96667574
100NANOG_16153702_ChIP-ChIP_HESCs_Human0.96386778
101ERG_20887958_ChIP-Seq_HPC-7_Mouse0.96310813
102CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.95987907
103CTBP1_25329375_ChIP-Seq_LNCAP_Human0.95954918
104RBPJ_22232070_ChIP-Seq_NCS_Mouse0.95567338
105PCGF2_27294783_Chip-Seq_NPCs_Mouse0.94135847
106POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.93246609
107SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.91888305
108SOX17_20123909_ChIP-Seq_XEN_Mouse0.91682172
109SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.91476631
110CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.91219557
111BP1_19119308_ChIP-ChIP_Hs578T_Human0.91046551
112SOX2_18692474_ChIP-Seq_MEFs_Mouse0.90848359
113PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.90366594
114TCF3_18692474_ChIP-Seq_MESCs_Mouse0.90218062
115TP53_22573176_ChIP-Seq_HFKS_Human0.90095174
116SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.89924253
117DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.88569266
118FUS_26573619_Chip-Seq_HEK293_Human0.88325219
119CRX_20693478_ChIP-Seq_RETINA_Mouse0.88053238
120BCAT_22108803_ChIP-Seq_LS180_Human0.87183294
121UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.86943140
122BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.85255469
123SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.84847322
124TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.84503027
125OCT4_18692474_ChIP-Seq_MEFs_Mouse0.83886500
126FOXA1_25329375_ChIP-Seq_VCAP_Human0.83397180
127FOXA1_27270436_Chip-Seq_PROSTATE_Human0.83397180
128TCF4_22108803_ChIP-Seq_LS180_Human0.83318823
129NANOG_18692474_ChIP-Seq_MEFs_Mouse0.82905915
130STAT3_1855785_ChIP-Seq_MESCs_Mouse0.81468108
131CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.80208882
132FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.79260307
133KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.79128964
134ZFX_18555785_ChIP-Seq_MESCs_Mouse0.78642786
135FLI1_27457419_Chip-Seq_LIVER_Mouse0.77694244
136EWS_26573619_Chip-Seq_HEK293_Human0.75354598
137SALL1_21062744_ChIP-ChIP_HESCs_Human0.74488151
138E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.73251323
139NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.72800619

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation4.24264690
2MP0003693_abnormal_embryo_hatching3.63638503
3MP0003136_yellow_coat_color3.51075368
4MP0008057_abnormal_DNA_replication3.29870486
5MP0010094_abnormal_chromosome_stability3.18491706
6MP0003195_calcinosis3.18149546
7MP0004957_abnormal_blastocyst_morpholog3.15391236
8MP0003111_abnormal_nucleus_morphology2.79440528
9MP0003077_abnormal_cell_cycle2.73957841
10MP0008058_abnormal_DNA_repair2.68024565
11MP0003806_abnormal_nucleotide_metabolis2.62008761
12MP0008932_abnormal_embryonic_tissue2.56337987
13MP0003786_premature_aging2.36112278
14MP0003718_maternal_effect2.23549424
15MP0006292_abnormal_olfactory_placode2.19172317
16MP0005409_darkened_coat_color2.16891554
17MP0009697_abnormal_copulation2.00325901
18MP0001188_hyperpigmentation1.92847711
19MP0003315_abnormal_perineum_morphology1.90001140
20MP0004381_abnormal_hair_follicle1.81588943
21MP0008260_abnormal_autophagy1.81515297
22MP0002102_abnormal_ear_morphology1.78515216
23MP0006036_abnormal_mitochondrial_physio1.76975160
24MP0002254_reproductive_system_inflammat1.75002702
25MP0008877_abnormal_DNA_methylation1.67738749
26MP0003787_abnormal_imprinting1.66622187
27MP0010030_abnormal_orbit_morphology1.62430386
28MP0002837_dystrophic_cardiac_calcinosis1.60485516
29MP0001529_abnormal_vocalization1.60413864
30MP0000049_abnormal_middle_ear1.58856885
31MP0005084_abnormal_gallbladder_morpholo1.57760456
32MP0002277_abnormal_respiratory_mucosa1.56535920
33MP0000566_synostosis1.55336332
34MP0003941_abnormal_skin_development1.52219402
35MP0008007_abnormal_cellular_replicative1.52129535
36MP0003937_abnormal_limbs/digits/tail_de1.50397185
37MP0003938_abnormal_ear_development1.48084263
38MP0002938_white_spotting1.46750134
39MP0003123_paternal_imprinting1.44044739
40MP0000350_abnormal_cell_proliferation1.41009787
41MP0002009_preneoplasia1.36786706
42MP0002751_abnormal_autonomic_nervous1.35732862
43MP0002736_abnormal_nociception_after1.34584374
44MP0005379_endocrine/exocrine_gland_phen1.33881542
45MP0005253_abnormal_eye_physiology1.33806596
46MP0006054_spinal_hemorrhage1.31570736
47MP0003011_delayed_dark_adaptation1.26488275
48MP0009333_abnormal_splenocyte_physiolog1.26435062
49MP0008789_abnormal_olfactory_epithelium1.25703841
50MP0002210_abnormal_sex_determination1.24955735
51MP0002090_abnormal_vision1.23194562
52MP0005551_abnormal_eye_electrophysiolog1.21076347
53MP0003567_abnormal_fetal_cardiomyocyte1.20799668
54MP0001293_anophthalmia1.19105236
55MP0000372_irregular_coat_pigmentation1.17553979
56MP0000647_abnormal_sebaceous_gland1.17390982
57MP0002249_abnormal_larynx_morphology1.16287174
58MP0005171_absent_coat_pigmentation1.15994207
59MP0002132_abnormal_respiratory_system1.15352764
60MP0001672_abnormal_embryogenesis/_devel1.14778713
61MP0005380_embryogenesis_phenotype1.14778713
62MP0001984_abnormal_olfaction1.12807712
63MP0003283_abnormal_digestive_organ1.11024189
64MP0005075_abnormal_melanosome_morpholog1.10697608
65MP0001730_embryonic_growth_arrest1.10381418
66MP0001286_abnormal_eye_development1.08938343
67MP0001485_abnormal_pinna_reflex1.08236316
68MP0008872_abnormal_physiological_respon1.07832649
69MP0002085_abnormal_embryonic_tissue1.06603622
70MP0005395_other_phenotype1.05756419
71MP0008995_early_reproductive_senescence1.05406868
72MP0000015_abnormal_ear_pigmentation1.01369260
73MP0001145_abnormal_male_reproductive1.00723630
74MP0002160_abnormal_reproductive_system1.00465809
75MP0004215_abnormal_myocardial_fiber0.99785111
76MP0000516_abnormal_urinary_system0.99742823
77MP0005367_renal/urinary_system_phenotyp0.99742823
78MP0001697_abnormal_embryo_size0.98028366
79MP0005332_abnormal_amino_acid0.97095514
80MP0001905_abnormal_dopamine_level0.96209602
81MP0002282_abnormal_trachea_morphology0.96141578
82MP0003121_genomic_imprinting0.95987787
83MP0003984_embryonic_growth_retardation0.95519408
84MP0005408_hypopigmentation0.95313467
85MP0009053_abnormal_anal_canal0.95273551
86MP0005174_abnormal_tail_pigmentation0.95004873
87MP0000427_abnormal_hair_cycle0.94928577
88MP0000358_abnormal_cell_content/0.94365214
89MP0003186_abnormal_redox_activity0.94299037
90MP0001324_abnormal_eye_pigmentation0.94275781
91MP0002088_abnormal_embryonic_growth/wei0.93709008
92MP0003755_abnormal_palate_morphology0.93230838
93MP0000762_abnormal_tongue_morphology0.92201535
94MP0000313_abnormal_cell_death0.91642587
95MP0000490_abnormal_crypts_of0.91550607
96MP0002234_abnormal_pharynx_morphology0.91262641
97MP0010307_abnormal_tumor_latency0.89816532
98MP0009250_abnormal_appendicular_skeleto0.88900654
99MP0001764_abnormal_homeostasis0.88120422
100MP0003890_abnormal_embryonic-extraembry0.87736484
101MP0010234_abnormal_vibrissa_follicle0.86691523
102MP0003950_abnormal_plasma_membrane0.86298122
103MP0004147_increased_porphyrin_level0.85767518
104MP0002177_abnormal_outer_ear0.84449515
105MP0010352_gastrointestinal_tract_polyps0.83340288
106MP0000653_abnormal_sex_gland0.82733132
107MP0005389_reproductive_system_phenotype0.81968350
108MP0002163_abnormal_gland_morphology0.81789950
109MP0002080_prenatal_lethality0.80868958
110MP0002084_abnormal_developmental_patter0.80790970
111MP0001929_abnormal_gametogenesis0.80445380
112MP0000432_abnormal_head_morphology0.80398937
113MP0003936_abnormal_reproductive_system0.79698673
114MP0004142_abnormal_muscle_tone0.79398526
115MP0004197_abnormal_fetal_growth/weight/0.78618066
116MP0006035_abnormal_mitochondrial_morpho0.77400004
117MP0004133_heterotaxia0.76878676
118MP0003861_abnormal_nervous_system0.76107884
119MP0003122_maternal_imprinting0.74841121
120MP0001727_abnormal_embryo_implantation0.74594555
121MP0003119_abnormal_digestive_system0.73747995
122MP0001919_abnormal_reproductive_system0.73420345
123MP0000026_abnormal_inner_ear0.72746485
124MP0002233_abnormal_nose_morphology0.72647087
125MP0000428_abnormal_craniofacial_morphol0.72096182
126MP0006072_abnormal_retinal_apoptosis0.72088117
127MP0000631_abnormal_neuroendocrine_gland0.71987762
128MP0009046_muscle_twitch0.71857821
129MP0002095_abnormal_skin_pigmentation0.71727861
130MP0001968_abnormal_touch/_nociception0.71055809
131MP0003137_abnormal_impulse_conducting0.70121320
132MP0003385_abnormal_body_wall0.70076216
133MP0002019_abnormal_tumor_incidence0.69528178
134MP0001119_abnormal_female_reproductive0.68298485
135MP0003698_abnormal_male_reproductive0.67802430
136MP0000778_abnormal_nervous_system0.66299590
137MP0008875_abnormal_xenobiotic_pharmacok0.66227482
138MP0002111_abnormal_tail_morphology0.66114219
139MP0002697_abnormal_eye_size0.64858557
140MP0000750_abnormal_muscle_regeneration0.64768081

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)4.70418816
2Reticulocytopenia (HP:0001896)4.61526710
3Abnormal number of erythroid precursors (HP:0012131)4.15478350
4Parakeratosis (HP:0001036)3.77491070
5Macrocytic anemia (HP:0001972)3.59501679
6Increased hepatocellular lipid droplets (HP:0006565)3.23158167
7Birth length less than 3rd percentile (HP:0003561)3.14885433
8Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.12012907
9Absent radius (HP:0003974)3.11706267
10Ependymoma (HP:0002888)3.06169181
11Breast hypoplasia (HP:0003187)3.04497950
12Pallor (HP:0000980)2.98824434
13Chromsome breakage (HP:0040012)2.98208474
14Colon cancer (HP:0003003)2.97376416
15Acute necrotizing encephalopathy (HP:0006965)2.96252395
16Chromosomal breakage induced by crosslinking agents (HP:0003221)2.94046303
17Absent forearm bone (HP:0003953)2.93412704
18Aplasia involving forearm bones (HP:0009822)2.93412704
19Neoplasm of the adrenal gland (HP:0100631)2.88779732
20Patellar aplasia (HP:0006443)2.87260257
21Absent thumb (HP:0009777)2.87131462
22Abnormality of methionine metabolism (HP:0010901)2.86941927
23Carpal bone hypoplasia (HP:0001498)2.83759898
24Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.82412232
25Methylmalonic acidemia (HP:0002912)2.82097822
26Hypothermia (HP:0002045)2.77090720
27Aplasia/Hypoplasia of the patella (HP:0006498)2.75843641
283-Methylglutaconic aciduria (HP:0003535)2.73717967
29Neoplasm of the adrenal cortex (HP:0100641)2.73639320
30Abnormality of aspartate family amino acid metabolism (HP:0010899)2.71050076
31Triphalangeal thumb (HP:0001199)2.66394112
32Mitochondrial inheritance (HP:0001427)2.66305387
33Type I transferrin isoform profile (HP:0003642)2.63036574
34Supernumerary spleens (HP:0009799)2.61937651
35Pancreatic islet-cell hyperplasia (HP:0004510)2.59241016
36Progressive macrocephaly (HP:0004481)2.56454931
37Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.55931021
38Aplasia/Hypoplasia of the sacrum (HP:0008517)2.55630166
39Meckel diverticulum (HP:0002245)2.54625628
40Renal Fanconi syndrome (HP:0001994)2.53472045
41Abnormality of the preputium (HP:0100587)2.53386890
42Intestinal atresia (HP:0011100)2.53329298
43Pancreatic cysts (HP:0001737)2.52976851
44Abnormal lung lobation (HP:0002101)2.52738397
45Hepatic necrosis (HP:0002605)2.48854755
46Horseshoe kidney (HP:0000085)2.47915023
47Exertional dyspnea (HP:0002875)2.47771062
48Lipid accumulation in hepatocytes (HP:0006561)2.46160248
49Abnormality of the ileum (HP:0001549)2.42055855
50Abnormality of chromosome stability (HP:0003220)2.39634287
51Rough bone trabeculation (HP:0100670)2.38499055
52Cerebral edema (HP:0002181)2.37945730
53Hypoglycemic seizures (HP:0002173)2.37055338
54Hyperinsulinemic hypoglycemia (HP:0000825)2.36444811
55Methylmalonic aciduria (HP:0012120)2.35804182
56Abnormality of the labia minora (HP:0012880)2.35535754
57Impulsivity (HP:0100710)2.35331365
58Aplasia/Hypoplasia of the fovea (HP:0008060)2.34414946
59Hypoplasia of the fovea (HP:0007750)2.34414946
60Hypoglycemic coma (HP:0001325)2.32954749
61Glioma (HP:0009733)2.32859095
62Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.31404312
63Abnormality of the duodenum (HP:0002246)2.31018633
64Increased serum lactate (HP:0002151)2.28298195
65Abnormality of the septum pellucidum (HP:0007375)2.28105905
66Concave nail (HP:0001598)2.26705330
67Pancreatic fibrosis (HP:0100732)2.26077205
68Astrocytoma (HP:0009592)2.25642686
69Abnormality of the astrocytes (HP:0100707)2.25642686
70Congenital, generalized hypertrichosis (HP:0004540)2.24738565
71Abnormality of the axillary hair (HP:0100134)2.24476763
72Abnormality of secondary sexual hair (HP:0009888)2.24476763
73Increased CSF lactate (HP:0002490)2.23433570
74Stenosis of the external auditory canal (HP:0000402)2.21717919
75Abnormal mitochondria in muscle tissue (HP:0008316)2.21451617
76Aplasia/Hypoplasia of the uvula (HP:0010293)2.21326851
77Abnormality of serum amino acid levels (HP:0003112)2.21308831
78Cerebral hypomyelination (HP:0006808)2.19586319
79Duplicated collecting system (HP:0000081)2.18769443
80Sparse lateral eyebrow (HP:0005338)2.15944038
81True hermaphroditism (HP:0010459)2.15747164
82Abnormal number of incisors (HP:0011064)2.14492396
83Septo-optic dysplasia (HP:0100842)2.14035452
84Aplasia/Hypoplasia involving the musculature (HP:0001460)2.12866118
85Hypoplasia of the radius (HP:0002984)2.12700058
86Abnormality of the fovea (HP:0000493)2.12465426
87Respiratory difficulties (HP:0002880)2.12299243
88Rectovaginal fistula (HP:0000143)2.11420174
89Rectal fistula (HP:0100590)2.11420174
90Aplastic anemia (HP:0001915)2.09109429
91Abnormality of midbrain morphology (HP:0002418)2.07486093
92Molar tooth sign on MRI (HP:0002419)2.07486093
93Abnormality of endocrine pancreas physiology (HP:0012093)2.06173861
94Abnormality of the pancreatic islet cells (HP:0006476)2.06173861
95Volvulus (HP:0002580)2.05165822
96Adrenal hypoplasia (HP:0000835)2.03879188
97Cleft eyelid (HP:0000625)2.02023115
98Abnormality of vitamin B metabolism (HP:0004340)2.00770441
99Sensory axonal neuropathy (HP:0003390)2.00516409
100Congenital ichthyosiform erythroderma (HP:0007431)1.98859571
101Premature graying of hair (HP:0002216)1.98640345
102Nephroblastoma (Wilms tumor) (HP:0002667)1.97663052
103Sloping forehead (HP:0000340)1.96393693
104Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.96371129
105Abnormal protein N-linked glycosylation (HP:0012347)1.96371129
106Abnormal protein glycosylation (HP:0012346)1.96371129
107Abnormal glycosylation (HP:0012345)1.96371129
108Lactic acidosis (HP:0003128)1.94847003
109Acute encephalopathy (HP:0006846)1.94640757
110Abnormal trabecular bone morphology (HP:0100671)1.94071069
111Hepatocellular necrosis (HP:0001404)1.93254858
112Absent septum pellucidum (HP:0001331)1.93137776
113Selective tooth agenesis (HP:0001592)1.91976006
114Respiratory failure (HP:0002878)1.91968560
115Hypomagnesemia (HP:0002917)1.89841153
116Oral leukoplakia (HP:0002745)1.89223250
117Abnormality of alanine metabolism (HP:0010916)1.89098881
118Hyperalaninemia (HP:0003348)1.89098881
119Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.89098881
120Abnormality of glycolysis (HP:0004366)1.88977014
121Increased serum pyruvate (HP:0003542)1.88977014
122Hyperglycinemia (HP:0002154)1.88896964
123Intestinal fistula (HP:0100819)1.88780886
124Ectopic kidney (HP:0000086)1.87624614
125Amniotic constriction ring (HP:0009775)1.86649030
126Abnormality of placental membranes (HP:0011409)1.86649030
127Megaloblastic anemia (HP:0001889)1.86557579
128Embryonal renal neoplasm (HP:0011794)1.85858451
129Lethargy (HP:0001254)1.85543029
130Symptomatic seizures (HP:0011145)1.84445476
131Abnormality of the renal collecting system (HP:0004742)1.84268347
132Trismus (HP:0000211)1.83724019
133Clubbing of toes (HP:0100760)1.82288781
134Prominent metopic ridge (HP:0005487)1.79763002
135Breast carcinoma (HP:0003002)1.78640239
136Bone marrow hypocellularity (HP:0005528)1.78161211
137Duplication of thumb phalanx (HP:0009942)1.78067581
138Ketoacidosis (HP:0001993)1.78056496
139Small intestinal stenosis (HP:0012848)1.78050487
140Duodenal stenosis (HP:0100867)1.78050487
141Abnormality of the vitamin B12 metabolism (HP:0004341)1.76487249
142Optic disc pallor (HP:0000543)1.75379102
143Degeneration of anterior horn cells (HP:0002398)1.74933978
144Abnormality of the anterior horn cell (HP:0006802)1.74933978
145Aplasia/hypoplasia of the humerus (HP:0006507)1.74246773
146Abnormality of serine family amino acid metabolism (HP:0010894)1.74229898
147Abnormality of glycine metabolism (HP:0010895)1.74229898
148Abnormality of sulfur amino acid metabolism (HP:0004339)1.74034618
149Abnormality of abdominal situs (HP:0011620)1.73042283
150Abdominal situs inversus (HP:0003363)1.73042283
151Leukodystrophy (HP:0002415)1.72870856
152Short thumb (HP:0009778)1.72835223
153Secondary amenorrhea (HP:0000869)1.72757084
154Bifid tongue (HP:0010297)1.71598915
155Medial flaring of the eyebrow (HP:0010747)1.71300353
156Abnormality of the pons (HP:0007361)1.70417227
157Asplenia (HP:0001746)1.70239009
158Atresia of the external auditory canal (HP:0000413)1.70015571
159Abnormality of homocysteine metabolism (HP:0010919)1.68918552
160Homocystinuria (HP:0002156)1.68918552
161Capillary hemangiomas (HP:0005306)1.68339734
162Anencephaly (HP:0002323)1.65519011
163Aplasia/Hypoplasia of the ulna (HP:0006495)1.65197123
164Rhabdomyosarcoma (HP:0002859)1.64984703

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK34.46113820
2SRPK14.01496735
3BUB13.51202126
4TRIM283.24316054
5WEE13.14014704
6MKNK23.08030575
7MKNK13.01891322
8NME22.95237883
9VRK22.88941014
10FRK2.80085419
11TLK12.45414417
12WNK32.42822747
13TESK22.41918605
14EIF2AK22.11418945
15VRK12.01942971
16STK162.01339659
17PLK42.00658536
18NEK11.97362129
19PBK1.95714397
20EIF2AK11.87721608
21TAF11.85254158
22CDC71.80074991
23LIMK11.77019159
24PIM21.72444646
25MAP4K21.68197690
26PLK31.60945849
27MST41.54405310
28PNCK1.49002618
29CASK1.48523871
30DYRK21.48212553
31MUSK1.46306889
32ERBB31.45354461
33BRSK21.44385152
34ZAK1.43361059
35AKT31.42644253
36CDK71.35378566
37PLK11.34875014
38GRK11.24865721
39BCR1.22834522
40NME11.19973809
41TTK1.19255690
42YES11.18603443
43PIM11.18039393
44CHEK21.17951098
45NLK1.10714896
46FGFR21.10630546
47PDK21.07840110
48AURKB1.01845361
49TNIK1.01781525
50OXSR11.00890587
51CDK120.99668338
52STK390.99313986
53CSNK1G10.97399930
54AURKA0.96817618
55CLK10.94734895
56STK40.93495653
57MAP3K120.92255588
58RPS6KA50.87909209
59TSSK60.87284573
60ACVR1B0.85464112
61DYRK30.83972691
62PASK0.83290348
63INSRR0.82965040
64PAK30.82022225
65GRK60.80548293
66EPHA20.80203271
67UHMK10.79565732
68ATR0.79426704
69CSNK2A10.79242381
70GRK70.79123264
71TGFBR10.76995310
72STK240.76055422
73PAK10.74838357
74CSNK1G20.74737406
75FER0.73832242
76TESK10.73775449
77CSNK2A20.69938924
78STK38L0.68757842
79NEK20.67797796
80CSNK1G30.66785453
81CHEK10.66662035
82ATM0.65320690
83SIK30.63568022
84CDK40.62331929
85DAPK10.60302209
86PRPF4B0.58516457
87RPS6KB20.58145363
88ADRBK20.58130130
89CDK20.57608782
90IRAK40.55742057
91TRPM70.55278169
92BMPR1B0.54901641
93ALK0.54777287
94FGFR10.53993008
95STK100.53509439
96ILK0.53232116
97PHKG20.52940716
98PHKG10.52940716
99BRAF0.51968209
100CCNB10.50515815
101PRKCE0.49789097
102BRSK10.49292655
103CDK10.48963828
104CDK80.48537917
105PRKCG0.47951689
106BCKDK0.47116665
107IKBKB0.45791188
108ABL20.43612122
109NEK60.42039331
110MAPK40.40820945
111CDK60.40261213
112WNK40.39010262
113TXK0.37746282
114FGR0.37425837
115CSNK1A1L0.37370500
116MAPKAPK50.36992640
117CDK30.36161017
118MAPK130.35128284
119PRKCI0.34574123
120TEC0.34309702
121LRRK20.34258781
122NUAK10.33966386
123STK30.33338987
124MARK30.32987567
125CSNK1E0.32369448
126MAP3K40.32218345
127PAK40.30959030
128PINK10.29052811
129PLK20.28495932
130MINK10.28486443
131DYRK1A0.28259192
132PKN10.27994538
133TIE10.27971991
134PRKDC0.26317290
135CSNK1A10.25668657
136MELK0.25438541
137GRK50.25175750
138ADRBK10.22908387
139FLT30.22756192
140ERBB40.22483895
141AKT20.22334762
142IRAK30.21836776

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.23654978
2RNA polymerase_Homo sapiens_hsa030203.90691412
3Proteasome_Homo sapiens_hsa030503.66395181
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.45127886
5DNA replication_Homo sapiens_hsa030303.34957676
6Spliceosome_Homo sapiens_hsa030403.19708137
7Mismatch repair_Homo sapiens_hsa034303.00749618
8Homologous recombination_Homo sapiens_hsa034402.81915722
9Oxidative phosphorylation_Homo sapiens_hsa001902.54744588
10RNA transport_Homo sapiens_hsa030132.54341379
11Nucleotide excision repair_Homo sapiens_hsa034202.41454364
12Basal transcription factors_Homo sapiens_hsa030222.40208588
13Pyrimidine metabolism_Homo sapiens_hsa002402.30715456
14Fanconi anemia pathway_Homo sapiens_hsa034602.24070802
15Parkinsons disease_Homo sapiens_hsa050122.19964540
16Propanoate metabolism_Homo sapiens_hsa006402.13967510
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.06200188
18Base excision repair_Homo sapiens_hsa034102.01983963
19Huntingtons disease_Homo sapiens_hsa050161.97921730
20Cell cycle_Homo sapiens_hsa041101.94046536
21Non-homologous end-joining_Homo sapiens_hsa034501.88976850
22Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.73421391
23RNA degradation_Homo sapiens_hsa030181.69367740
24Protein export_Homo sapiens_hsa030601.65608313
25Cysteine and methionine metabolism_Homo sapiens_hsa002701.63180563
26Selenocompound metabolism_Homo sapiens_hsa004501.56607534
27Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.56390458
28Alzheimers disease_Homo sapiens_hsa050101.51492999
29Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.50213558
30Maturity onset diabetes of the young_Homo sapiens_hsa049501.46397309
31Pyruvate metabolism_Homo sapiens_hsa006201.46304688
32Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.44615823
33One carbon pool by folate_Homo sapiens_hsa006701.41976409
34mRNA surveillance pathway_Homo sapiens_hsa030151.40550686
35Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.39399243
36p53 signaling pathway_Homo sapiens_hsa041151.37190887
37Butanoate metabolism_Homo sapiens_hsa006501.36034194
38Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.34053446
39Purine metabolism_Homo sapiens_hsa002301.32351525
402-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.28583428
41Systemic lupus erythematosus_Homo sapiens_hsa053221.25932109
42Vitamin B6 metabolism_Homo sapiens_hsa007501.23700165
43Epstein-Barr virus infection_Homo sapiens_hsa051691.09304967
44Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.05905805
45Graft-versus-host disease_Homo sapiens_hsa053320.95506904
46Sulfur metabolism_Homo sapiens_hsa009200.94000713
47Tryptophan metabolism_Homo sapiens_hsa003800.91097939
48Carbon metabolism_Homo sapiens_hsa012000.87186600
49Caffeine metabolism_Homo sapiens_hsa002320.86008323
50Peroxisome_Homo sapiens_hsa041460.84414902
51Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.84167338
52Autoimmune thyroid disease_Homo sapiens_hsa053200.84139526
53Arachidonic acid metabolism_Homo sapiens_hsa005900.82217122
54Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.81479266
55Steroid biosynthesis_Homo sapiens_hsa001000.79893257
56Nitrogen metabolism_Homo sapiens_hsa009100.79565035
57Pentose and glucuronate interconversions_Homo sapiens_hsa000400.77971571
58Allograft rejection_Homo sapiens_hsa053300.77368611
59Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.75829414
60Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.72516254
61Viral carcinogenesis_Homo sapiens_hsa052030.72213182
62Biosynthesis of amino acids_Homo sapiens_hsa012300.71111101
63Fatty acid metabolism_Homo sapiens_hsa012120.70075936
64Fatty acid degradation_Homo sapiens_hsa000710.68534631
65Herpes simplex infection_Homo sapiens_hsa051680.68142487
66beta-Alanine metabolism_Homo sapiens_hsa004100.68036630
67Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.67972754
68Asthma_Homo sapiens_hsa053100.66099852
69Cardiac muscle contraction_Homo sapiens_hsa042600.65584829
70Glutathione metabolism_Homo sapiens_hsa004800.61889572
71Collecting duct acid secretion_Homo sapiens_hsa049660.61147123
72Transcriptional misregulation in cancer_Homo sapiens_hsa052020.60897722
73Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.58183898
74Ether lipid metabolism_Homo sapiens_hsa005650.56679374
75Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.54224200
76N-Glycan biosynthesis_Homo sapiens_hsa005100.53410480
77Primary bile acid biosynthesis_Homo sapiens_hsa001200.51216351
78Intestinal immune network for IgA production_Homo sapiens_hsa046720.49871101
79Basal cell carcinoma_Homo sapiens_hsa052170.49615504
80Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.48633778
81Oocyte meiosis_Homo sapiens_hsa041140.46918849
82Phototransduction_Homo sapiens_hsa047440.45902001
83Retinol metabolism_Homo sapiens_hsa008300.45839531
84Linoleic acid metabolism_Homo sapiens_hsa005910.45743788
85MicroRNAs in cancer_Homo sapiens_hsa052060.44722342
86Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.44306394
87Alcoholism_Homo sapiens_hsa050340.44292246
88Vitamin digestion and absorption_Homo sapiens_hsa049770.43850819
89Regulation of autophagy_Homo sapiens_hsa041400.42784842
90Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.41049155
91Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.40917423
92Chemical carcinogenesis_Homo sapiens_hsa052040.40276866
93Metabolic pathways_Homo sapiens_hsa011000.39577592
94Primary immunodeficiency_Homo sapiens_hsa053400.39505566
95Sphingolipid metabolism_Homo sapiens_hsa006000.39332802
96Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.38924454
97Arginine and proline metabolism_Homo sapiens_hsa003300.38920970
98Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.38542724
99Drug metabolism - other enzymes_Homo sapiens_hsa009830.38232915
100Hedgehog signaling pathway_Homo sapiens_hsa043400.38174156
101Fatty acid elongation_Homo sapiens_hsa000620.37221481
102Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.36371772
103Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.35461864
104Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.35091209
105NF-kappa B signaling pathway_Homo sapiens_hsa040640.34925585
106Cyanoamino acid metabolism_Homo sapiens_hsa004600.34440943
107Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.33210965
108Folate biosynthesis_Homo sapiens_hsa007900.33200664
109HTLV-I infection_Homo sapiens_hsa051660.33012189
110Wnt signaling pathway_Homo sapiens_hsa043100.32048010
111Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.31538352
112Prostate cancer_Homo sapiens_hsa052150.30725530
113SNARE interactions in vesicular transport_Homo sapiens_hsa041300.28315435
114Hematopoietic cell lineage_Homo sapiens_hsa046400.28063437
115Circadian rhythm_Homo sapiens_hsa047100.27897541
116Mineral absorption_Homo sapiens_hsa049780.27847320
117Antigen processing and presentation_Homo sapiens_hsa046120.27813206
118TGF-beta signaling pathway_Homo sapiens_hsa043500.27115303
119Hippo signaling pathway_Homo sapiens_hsa043900.26370114
120Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.26309433
121Measles_Homo sapiens_hsa051620.26189962
122NOD-like receptor signaling pathway_Homo sapiens_hsa046210.26177596
123Lysine degradation_Homo sapiens_hsa003100.26016723
124Fat digestion and absorption_Homo sapiens_hsa049750.25867610
125Pathways in cancer_Homo sapiens_hsa052000.25358450
126Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.24067435
127Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.23549418
128Small cell lung cancer_Homo sapiens_hsa052220.22461794
129Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.21896090
130alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.19671663
131Rheumatoid arthritis_Homo sapiens_hsa053230.19632809
132Thyroid cancer_Homo sapiens_hsa052160.19410543
133Viral myocarditis_Homo sapiens_hsa054160.18949022
134Melanoma_Homo sapiens_hsa052180.18760849
135Apoptosis_Homo sapiens_hsa042100.17146870
136Malaria_Homo sapiens_hsa051440.15686817
137Notch signaling pathway_Homo sapiens_hsa043300.15592517
138Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.14993916
139Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.14709271
140PI3K-Akt signaling pathway_Homo sapiens_hsa041510.12857420
141Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.12116064
142Jak-STAT signaling pathway_Homo sapiens_hsa046300.10950585
143Pentose phosphate pathway_Homo sapiens_hsa000300.10271617

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