ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	establishment of integrated proviral latency (GO:0075713)	4.78834454
2	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	4.61127413
3	negative regulation of retinoic acid receptor signaling pathway (GO:0048387)	4.39241558
4	ribosome assembly (GO:0042255)	4.12610715
5	establishment of viral latency (GO:0019043)	4.10487698
6	DNA unwinding involved in DNA replication (GO:0006268)	4.00947635
7	maturation of 5.8S rRNA (GO:0000460)	3.93351692
8	regulation of retinoic acid receptor signaling pathway (GO:0048385)	3.92040930
9	ribonucleoprotein complex disassembly (GO:0032988)	3.85851961
10	cullin deneddylation (GO:0010388)	3.72024818
11	de novo protein folding (GO:0006458)	3.67894189
12	peptidyl-arginine omega-N-methylation (GO:0035247)	3.66592278
13	metallo-sulfur cluster assembly (GO:0031163)	3.65208023
14	iron-sulfur cluster assembly (GO:0016226)	3.65208023
15	de novo posttranslational protein folding (GO:0051084)	3.62378364
16	protein localization to chromosome, centromeric region (GO:0071459)	3.62253761
17	protein deneddylation (GO:0000338)	3.60872758
18	DNA strand elongation involved in DNA replication (GO:0006271)	3.57846727
19	DNA strand elongation (GO:0022616)	3.56322313
20	proteasome assembly (GO:0043248)	3.50262805
21	regulation of mitochondrial translation (GO:0070129)	3.49982199
22	deoxyribose phosphate biosynthetic process (GO:0046385)	3.48833961
23	2-deoxyribonucleotide biosynthetic process (GO:0009265)	3.48833961
24	spliceosomal snRNP assembly (GO:0000387)	3.45890388
25	tRNA aminoacylation for protein translation (GO:0006418)	3.43212295
26	telomere maintenance via semi-conservative replication (GO:0032201)	3.37198933
27	deoxyribonucleotide biosynthetic process (GO:0009263)	3.37180997
28	amino acid activation (GO:0043038)	3.37111326
29	tRNA aminoacylation (GO:0043039)	3.37111326
30	microtubule depolymerization (GO:0007019)	3.29611640
31	peptidyl-arginine N-methylation (GO:0035246)	3.26951554
32	peptidyl-arginine methylation (GO:0018216)	3.26951554
33	organelle disassembly (GO:1903008)	3.25504929
34	nuclear pore complex assembly (GO:0051292)	3.25459449
35	histone arginine methylation (GO:0034969)	3.24555073
36	COPI coating of Golgi vesicle (GO:0048205)	3.23047011
37	Golgi transport vesicle coating (GO:0048200)	3.23047011
38	DNA replication-dependent nucleosome organization (GO:0034723)	3.20092066
39	DNA replication-dependent nucleosome assembly (GO:0006335)	3.20092066
40	protein localization to kinetochore (GO:0034501)	3.15299825
41	DNA damage response, detection of DNA damage (GO:0042769)	3.11538608
42	CENP-A containing nucleosome assembly (GO:0034080)	3.09776396
43	formation of translation preinitiation complex (GO:0001731)	3.09277577
44	positive regulation of mitochondrial fission (GO:0090141)	3.08494999
45	mitotic metaphase plate congression (GO:0007080)	3.08333219
46	mitochondrial RNA metabolic process (GO:0000959)	3.08156919
47	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	3.07400945
48	protein targeting to mitochondrion (GO:0006626)	3.04140725
49	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.03708135
50	negative regulation of mRNA splicing, via spliceosome (GO:0048025)	3.03392351
51	deoxyribonucleoside triphosphate metabolic process (GO:0009200)	3.01151476
52	DNA ligation (GO:0006266)	2.98700835
53	mitochondrial calcium ion transport (GO:0006851)	2.97844361
54	pseudouridine synthesis (GO:0001522)	2.97743614
55	rRNA modification (GO:0000154)	2.97001036
56	ribosome biogenesis (GO:0042254)	2.96646249
57	nuclear pore organization (GO:0006999)	2.95831062
58	transcription from mitochondrial promoter (GO:0006390)	2.94623975
59	protein maturation by protein folding (GO:0022417)	2.94247056
60	nucleotide-excision repair, DNA gap filling (GO:0006297)	2.93512164
61	base-excision repair (GO:0006284)	2.92763482
62	histone mRNA metabolic process (GO:0008334)	2.90115916
63	DNA double-strand break processing (GO:0000729)	2.89665576
64	7-methylguanosine mRNA capping (GO:0006370)	2.87583768
65	ubiquinone metabolic process (GO:0006743)	2.87289794
66	transcription-coupled nucleotide-excision repair (GO:0006283)	2.86045303
67	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.85596548
68	viral mRNA export from host cell nucleus (GO:0046784)	2.83516392
69	chromatin remodeling at centromere (GO:0031055)	2.83210260
70	histone H2B ubiquitination (GO:0033523)	2.82263365
71	chaperone-mediated protein transport (GO:0072321)	2.82193628
72	termination of RNA polymerase II transcription (GO:0006369)	2.82032727
73	telomere maintenance via recombination (GO:0000722)	2.81349182
74	RNA capping (GO:0036260)	2.78842214
75	7-methylguanosine RNA capping (GO:0009452)	2.78842214
76	mitochondrial fission (GO:0000266)	2.78247414
77	non-recombinational repair (GO:0000726)	2.76254809
78	double-strand break repair via nonhomologous end joining (GO:0006303)	2.76254809
79	establishment of protein localization to mitochondrion (GO:0072655)	2.75987168
80	DNA topological change (GO:0006265)	2.75898887
81	mitotic nuclear envelope disassembly (GO:0007077)	2.75307807
82	mitochondrial fragmentation involved in apoptotic process (GO:0043653)	2.74360308
83	protein localization to mitochondrion (GO:0070585)	2.74032927
84	negative regulation of RNA splicing (GO:0033119)	2.73831304
85	regulation of helicase activity (GO:0051095)	2.73669881
86	protein localization to chromosome (GO:0034502)	2.73498143
87	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.72439712
88	tRNA methylation (GO:0030488)	2.71659978
89	binding of sperm to zona pellucida (GO:0007339)	2.70561804
90	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	2.70517564
91	pore complex assembly (GO:0046931)	2.70135876
92	mitotic recombination (GO:0006312)	2.70090247
93	rRNA transcription (GO:0009303)	2.67431906
94	regulation of translational fidelity (GO:0006450)	2.67068204
95	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	2.66510885
96	peptidyl-histidine modification (GO:0018202)	2.65885691
97	rRNA methylation (GO:0031167)	2.65318849
98	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.65242925
99	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.64929886
100	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	2.63682279

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	5.76227738
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.23401191
3	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	4.03948966
4	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.51325468
5	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.47209243
6	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.42926218
7	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	3.40477385
8	CREB1_15753290_ChIP-ChIP_HEK293T_Human	3.35996287
9	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	3.31583461
10	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	3.28097626
11	ETS1_20019798_ChIP-Seq_JURKAT_Human	3.12181105
12	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.06906857
13	E2F4_17652178_ChIP-ChIP_JURKAT_Human	3.01770646
14	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.95395841
15	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.83014016
16	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.68727472
17	DCP1A_22483619_ChIP-Seq_HELA_Human	2.66658772
18	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.65449912
19	NELFA_20434984_ChIP-Seq_ESCs_Mouse	2.65252741
20	THAP11_20581084_ChIP-Seq_MESCs_Mouse	2.61192501
21	VDR_23849224_ChIP-Seq_CD4+_Human	2.60435880
22	MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.56523323
23	GABP_19822575_ChIP-Seq_HepG2_Human	2.51562005
24	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.40436656
25	ELK1_19687146_ChIP-ChIP_HELA_Human	2.34575120
26	FOXP3_21729870_ChIP-Seq_TREG_Human	2.30981675
27	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.27437805
28	XRN2_22483619_ChIP-Seq_HELA_Human	2.23662497
29	E2F1_18555785_ChIP-Seq_MESCs_Mouse	2.21829430
30	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	2.20688353
31	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.11037080
32	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	2.04193466
33	TTF2_22483619_ChIP-Seq_HELA_Human	2.03577693
34	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	2.03203410
35	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	2.02178492
36	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.01041070
37	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.94972667
38	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.94437182
39	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.93806677
40	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.93072907
41	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.92716064
42	CIITA_25753668_ChIP-Seq_RAJI_Human	1.87883226
43	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.87245631
44	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.84969142
45	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.78075516
46	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.76426001
47	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.72111132
48	KDM5A_27292631_Chip-Seq_BREAST_Human	1.70780610
49	ZNF274_21170338_ChIP-Seq_K562_Hela	1.66341225
50	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.57279778
51	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.55845704
52	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.51766358
53	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	1.45725639
54	FOXM1_23109430_ChIP-Seq_U2OS_Human	1.44976966
55	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.43800928
56	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.43469941
57	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.41012163
58	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.40047566
59	TFEB_21752829_ChIP-Seq_HELA_Human	1.36317391
60	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.32951092
61	MYC_18940864_ChIP-ChIP_HL60_Human	1.32247512
62	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	1.31882105
63	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.31801322
64	ZNF263_19887448_ChIP-Seq_K562_Human	1.29102323
65	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.27954756
66	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.24215732
67	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.23182654
68	AR_21909140_ChIP-Seq_LNCAP_Human	1.21658717
69	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.21495177
70	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	1.20833303
71	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.18169179
72	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.18132755
73	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.16021410
74	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.15405265
75	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.14120198
76	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	1.12132019
77	IRF1_19129219_ChIP-ChIP_H3396_Human	1.11951366
78	GFI1B_20887958_ChIP-Seq_HPC-7_Mouse	1.10665758
79	IGF1R_20145208_ChIP-Seq_DFB_Human	1.05692086
80	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.04510072
81	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	1.04209989
82	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	0.99750635
83	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.98865583
84	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	0.98238310
85	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	0.91268979
86	SOX17_20123909_ChIP-Seq_XEN_Mouse	0.89643105
87	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	0.89324083
88	TRIM28_19339689_ChIP-ChIP_MESCs_Mouse	0.89224798
89	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.88790441
90	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.83847345
91	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	0.83534197
92	KLF4_18555785_ChIP-Seq_MESCs_Mouse	0.83370686
93	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.81091966
94	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	0.80837988
95	CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse	0.80804808
96	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	0.80740562
97	NANOG_21062744_ChIP-ChIP_HESCs_Human	0.77890739
98	RBPJ_22232070_ChIP-Seq_NCS_Mouse	0.71626684
99	TBX5_21415370_ChIP-Seq_HL-1_Mouse	0.71255238
100	CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse	0.70180132

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008058_abnormal_DNA_repair	4.18551554
2	MP0010094_abnormal_chromosome_stability	4.14088272
3	MP0004957_abnormal_blastocyst_morpholog	3.62466102
4	MP0001529_abnormal_vocalization	3.56042694
5	MP0003111_abnormal_nucleus_morphology	3.36512637
6	MP0003693_abnormal_embryo_hatching	3.35288024
7	MP0008932_abnormal_embryonic_tissue	3.25815309
8	MP0009697_abnormal_copulation	3.15462758
9	MP0005451_abnormal_body_composition	3.03997756
10	MP0003077_abnormal_cell_cycle	2.94296176
11	MP0003221_abnormal_cardiomyocyte_apopto	2.81152898
12	MP0008057_abnormal_DNA_replication	2.67504788
13	MP0003718_maternal_effect	2.60016366
14	MP0006035_abnormal_mitochondrial_morpho	2.25745526
15	MP0001730_embryonic_growth_arrest	2.23606376
16	MP0000647_abnormal_sebaceous_gland	2.21751610
17	MP0008007_abnormal_cellular_replicative	1.96242750
18	MP0008789_abnormal_olfactory_epithelium	1.91178678
19	MP0005394_taste/olfaction_phenotype	1.89708544
20	MP0005499_abnormal_olfactory_system	1.89708544
21	MP0005187_abnormal_penis_morphology	1.86089961
22	MP0006292_abnormal_olfactory_placode	1.83032610
23	MP0000358_abnormal_cell_content/	1.80880622
24	MP0004147_increased_porphyrin_level	1.75586452
25	MP0003186_abnormal_redox_activity	1.70101970
26	MP0005380_embryogenesis_phenotype	1.61779528
27	MP0001672_abnormal_embryogenesis/_devel	1.61779528
28	MP0000350_abnormal_cell_proliferation	1.59685760
29	MP0003567_abnormal_fetal_cardiomyocyte	1.53868546
30	MP0002080_prenatal_lethality	1.50458843
31	MP0003786_premature_aging	1.50397193
32	MP0001697_abnormal_embryo_size	1.45023501
33	MP0003984_embryonic_growth_retardation	1.42956871
34	MP0004233_abnormal_muscle_weight	1.39870565
35	MP0001727_abnormal_embryo_implantation	1.39362971
36	MP0005645_abnormal_hypothalamus_physiol	1.38158893
37	MP0001764_abnormal_homeostasis	1.36065765
38	MP0000313_abnormal_cell_death	1.35662230
39	MP0005084_abnormal_gallbladder_morpholo	1.32410698
40	MP0002088_abnormal_embryonic_growth/wei	1.31683971
41	MP0002009_preneoplasia	1.31521650
42	MP0003315_abnormal_perineum_morphology	1.30404940
43	MP0002234_abnormal_pharynx_morphology	1.25913617
44	MP0005410_abnormal_fertilization	1.24049588
45	MP0003806_abnormal_nucleotide_metabolis	1.22731843
46	MP0002160_abnormal_reproductive_system	1.19509082
47	MP0002877_abnormal_melanocyte_morpholog	1.18871146
48	MP0008260_abnormal_autophagy	1.17809508
49	MP0002084_abnormal_developmental_patter	1.16946688
50	MP0000372_irregular_coat_pigmentation	1.16525016
51	MP0002751_abnormal_autonomic_nervous	1.16305563
52	MP0000465_gastrointestinal_hemorrhage	1.13201887
53	MP0005501_abnormal_skin_physiology	1.13136657
54	MP0002085_abnormal_embryonic_tissue	1.12698523
55	MP0006072_abnormal_retinal_apoptosis	1.12674958
56	MP0002102_abnormal_ear_morphology	1.10701581
57	MP0001929_abnormal_gametogenesis	1.09791136
58	MP0008877_abnormal_DNA_methylation	1.07868357
59	MP0002210_abnormal_sex_determination	1.04848535
60	MP0004197_abnormal_fetal_growth/weight/	1.04438966
61	MP0010352_gastrointestinal_tract_polyps	1.02556586
62	MP0005384_cellular_phenotype	1.02284307
63	MP0006036_abnormal_mitochondrial_physio	1.00750360
64	MP0001293_anophthalmia	0.99990179
65	MP0008995_early_reproductive_senescence	0.99858612
66	MP0000490_abnormal_crypts_of	0.98074630
67	MP0002019_abnormal_tumor_incidence	0.94951247
68	MP0003656_abnormal_erythrocyte_physiolo	0.94307627
69	MP0003385_abnormal_body_wall	0.92631281
70	MP0002086_abnormal_extraembryonic_tissu	0.92275732
71	MP0002822_catalepsy	0.91743415
72	MP0003698_abnormal_male_reproductive	0.86965973
73	MP0001243_abnormal_dermal_layer	0.85966239
74	MP0002166_altered_tumor_susceptibility	0.83762933
75	MP0001145_abnormal_male_reproductive	0.82382663
76	MP0002177_abnormal_outer_ear	0.82202617
77	MP0000653_abnormal_sex_gland	0.81217854
78	MP0001661_extended_life_span	0.80455564
79	MP0005253_abnormal_eye_physiology	0.76867111
80	MP0003699_abnormal_female_reproductive	0.75052028
81	MP0002090_abnormal_vision	0.74997372
82	MP0005623_abnormal_meninges_morphology	0.74176786
83	MP0001340_abnormal_eyelid_morphology	0.73704150
84	MP0002161_abnormal_fertility/fecundity	0.73202998
85	MP0005621_abnormal_cell_physiology	0.72638740
86	MP0005646_abnormal_pituitary_gland	0.70145371
87	MP0010307_abnormal_tumor_latency	0.68530801
88	MP0005083_abnormal_biliary_tract	0.67075331
89	MP0002006_tumorigenesis	0.66588975
90	MP0003937_abnormal_limbs/digits/tail_de	0.65860402
91	MP0006276_abnormal_autonomic_nervous	0.65662225
92	MP0001286_abnormal_eye_development	0.64995295
93	MP0005395_other_phenotype	0.63699751
94	MP0000598_abnormal_liver_morphology	0.62641039
95	MP0002653_abnormal_ependyma_morphology	0.62324044
96	MP0005464_abnormal_platelet_physiology	0.60563022
97	MP0002098_abnormal_vibrissa_morphology	0.59944048
98	MP0008873_increased_physiological_sensi	0.59925046
99	MP0002269_muscular_atrophy	0.58266984
100	MP0001346_abnormal_lacrimal_gland	0.55943532

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Microvesicular hepatic steatosis (HP:0001414)	4.02486585
2	Increased serum pyruvate (HP:0003542)	3.74511165
3	Cortical dysplasia (HP:0002539)	3.70754136
4	Abnormality of the anterior horn cell (HP:0006802)	3.60167414
5	Degeneration of anterior horn cells (HP:0002398)	3.60167414
6	Lipid accumulation in hepatocytes (HP:0006561)	3.48472525
7	Increased hepatocellular lipid droplets (HP:0006565)	3.45426528
8	Abnormality of glycolysis (HP:0004366)	3.41776704
9	Abnormal mitochondria in muscle tissue (HP:0008316)	3.33609772
10	Decreased activity of mitochondrial respiratory chain (HP:0008972)	3.21775905
11	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	3.21775905
12	Ragged-red muscle fibers (HP:0003200)	3.15166717
13	Acute necrotizing encephalopathy (HP:0006965)	3.01326468
14	Entropion (HP:0000621)	2.97545326
15	Increased intramyocellular lipid droplets (HP:0012240)	2.88896878
16	Medulloblastoma (HP:0002885)	2.85101292
17	Upper limb muscle weakness (HP:0003484)	2.83132156
18	Increased CSF lactate (HP:0002490)	2.79000030
19	Acute encephalopathy (HP:0006846)	2.77964068
20	Shoulder girdle muscle weakness (HP:0003547)	2.69228111
21	Mitochondrial inheritance (HP:0001427)	2.68474856
22	Renal Fanconi syndrome (HP:0001994)	2.67920269
23	Increased serum lactate (HP:0002151)	2.65544629
24	Cholecystitis (HP:0001082)	2.63473159
25	Abnormal gallbladder physiology (HP:0012438)	2.63473159
26	Poikiloderma (HP:0001029)	2.61914590
27	Hepatocellular necrosis (HP:0001404)	2.60702204
28	Increased muscle lipid content (HP:0009058)	2.54918163
29	Multiple enchondromatosis (HP:0005701)	2.53303779
30	Atrophy/Degeneration involving motor neurons (HP:0007373)	2.50418560
31	Lactic acidosis (HP:0003128)	2.44623356
32	Abnormal protein glycosylation (HP:0012346)	2.43147901
33	Abnormal glycosylation (HP:0012345)	2.43147901
34	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.43147901
35	Abnormal protein N-linked glycosylation (HP:0012347)	2.43147901
36	Hyperglycinemia (HP:0002154)	2.40328544
37	Aplastic anemia (HP:0001915)	2.34748670
38	Autoamputation (HP:0001218)	2.33321135
39	Poor head control (HP:0002421)	2.30477275
40	Cerebral edema (HP:0002181)	2.30048399
41	Premature ovarian failure (HP:0008209)	2.29017275
42	Hepatic necrosis (HP:0002605)	2.28782317
43	Papillary thyroid carcinoma (HP:0002895)	2.27210216
44	Exercise intolerance (HP:0003546)	2.26842226
45	Fibular aplasia (HP:0002990)	2.26506265
46	Abnormality of the hip-girdle musculature (HP:0001445)	2.24018151
47	Abnormality of the musculature of the pelvis (HP:0001469)	2.24018151
48	Pelvic girdle muscle weakness (HP:0003749)	2.23412269
49	Abnormality of alanine metabolism (HP:0010916)	2.22173407
50	Hyperalaninemia (HP:0003348)	2.22173407
51	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.22173407
52	Retinal dysplasia (HP:0007973)	2.16970811
53	3-Methylglutaconic aciduria (HP:0003535)	2.16351773
54	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	2.14717069
55	Progressive muscle weakness (HP:0003323)	2.14583721
56	Reduced antithrombin III activity (HP:0001976)	2.07268534
57	Progressive macrocephaly (HP:0004481)	2.04650740
58	Decreased number of large peripheral myelinated nerve fibers (HP:0003387)	2.00176967
59	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.98201276
60	Hypoplastic pelvis (HP:0008839)	1.96825516
61	Exertional dyspnea (HP:0002875)	1.92533850
62	Proximal placement of thumb (HP:0009623)	1.90121061
63	Secondary amenorrhea (HP:0000869)	1.89994293
64	Type I transferrin isoform profile (HP:0003642)	1.89732997
65	Insidious onset (HP:0003587)	1.86284641
66	Termporal pattern (HP:0011008)	1.86284641
67	Postnatal microcephaly (HP:0005484)	1.84251635
68	Opisthotonus (HP:0002179)	1.84058224
69	Cholelithiasis (HP:0001081)	1.83116899
70	Short tibia (HP:0005736)	1.81968544
71	Generalized aminoaciduria (HP:0002909)	1.81651985
72	Chromsome breakage (HP:0040012)	1.81546525
73	Unilateral renal agenesis (HP:0000122)	1.79543391
74	Thyroid carcinoma (HP:0002890)	1.78337507
75	Meckel diverticulum (HP:0002245)	1.76022739
76	Abnormality of DNA repair (HP:0003254)	1.75637055
77	Limb-girdle muscle atrophy (HP:0003797)	1.74678711
78	Exercise-induced muscle cramps (HP:0003710)	1.74611703
79	Chromosomal breakage induced by crosslinking agents (HP:0003221)	1.74021024
80	Aplasia/hypoplasia of the uterus (HP:0008684)	1.73915628
81	Progressive microcephaly (HP:0000253)	1.73645051
82	Abnormal gallbladder morphology (HP:0012437)	1.72465507
83	Progressive hearing impairment (HP:0001730)	1.72016500
84	Sensorimotor neuropathy (HP:0007141)	1.70994164
85	Abnormality of the ileum (HP:0001549)	1.70338113
86	Orthostatic hypotension (HP:0001278)	1.68977376
87	Hypergonadotropic hypogonadism (HP:0000815)	1.67869079
88	Lissencephaly (HP:0001339)	1.67357196
89	Leukodystrophy (HP:0002415)	1.66134391
90	Deviation of the thumb (HP:0009603)	1.65882010
91	Congenital primary aphakia (HP:0007707)	1.64657308
92	Horseshoe kidney (HP:0000085)	1.64343084
93	Renal cortical cysts (HP:0000803)	1.64075875
94	Reticulocytosis (HP:0001923)	1.63383131
95	Cerebral hypomyelination (HP:0006808)	1.62925723
96	Male infertility (HP:0003251)	1.62750673
97	Pancytopenia (HP:0001876)	1.62454494
98	Nephrogenic diabetes insipidus (HP:0009806)	1.62453343
99	Cleft eyelid (HP:0000625)	1.62195211
100	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.61054648

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	SRPK1	4.41918939
2	TESK2	3.80481457
3	BCKDK	2.96467894
4	NEK1	2.90852216
5	BCR	2.78557986
6	MAP2K7	2.73272581
7	ZAK	2.61493769
8	VRK2	2.49078636
9	TRIM28	2.48992069
10	CDC7	2.38425851
11	VRK1	2.22662414
12	PIM2	2.18751884
13	EIF2AK1	2.17094670
14	MAP3K4	2.16646566
15	RPS6KA4	2.14942378
16	MST4	2.09949063
17	PBK	2.09591598
18	TESK1	2.07684054
19	STK16	1.99425283
20	CSNK1A1L	1.98456361
21	CSNK1G3	1.92663531
22	TSSK6	1.84114680
23	BUB1	1.63661488
24	MAP4K2	1.58822799
25	CSNK1G1	1.56447706
26	SCYL2	1.51842069
27	ARAF	1.48478327
28	TTK	1.46283409
29	CSNK1G2	1.44944757
30	AURKA	1.39971793
31	CCNB1	1.37555227
32	ATR	1.33770786
33	EPHA3	1.32969836
34	DYRK3	1.27113753
35	RPS6KA5	1.26362826
36	EIF2AK3	1.26356378
37	CDK19	1.18591369
38	CDK7	1.18585503
39	FLT3	1.15314062
40	AURKB	1.14722838
41	CHEK2	1.13838403
42	KDR	1.10022487
43	CDK12	1.09937148
44	CDK8	1.09584425
45	MAP3K5	1.05151862
46	PLK3	0.99636243
47	NME2	0.97375592
48	ERBB3	0.96861985
49	PLK1	0.96779526
50	DAPK1	0.92633331
51	CHEK1	0.91878867
52	RAF1	0.91407813
53	PLK4	0.90359611
54	ATM	0.82009021
55	NUAK1	0.81976602
56	CDK14	0.77242931
57	DYRK2	0.76562064
58	LIMK1	0.72284099
59	DAPK3	0.69772816
60	NME1	0.69650068
61	MAP3K6	0.66126888
62	WNK4	0.64063975
63	BRD4	0.62542775
64	CDK18	0.61832684
65	CDK11A	0.59036248
66	SIK3	0.58247621
67	CDK2	0.55170531
68	CDK15	0.55131090
69	TLK1	0.53321707
70	CDK9	0.53201083
71	CDK1	0.52425270
72	PAK1	0.50832663
73	TAOK2	0.50629164
74	CSNK2A2	0.49650563
75	NEK2	0.49550664
76	CSNK2A1	0.48980754
77	MAP3K8	0.46017516
78	MAPKAPK5	0.45303431
79	AKT2	0.45237253
80	PIM1	0.43884081
81	CDK4	0.43277541
82	CDK6	0.41208643
83	TAF1	0.40662144
84	STK39	0.39928498
85	CLK1	0.38686476
86	ERBB4	0.38360056
87	STK10	0.36510347
88	CSNK1E	0.34205183
89	DYRK1B	0.33838560
90	NEK9	0.33731856
91	EIF2AK2	0.32493311
92	CSNK1A1	0.31738881
93	MARK1	0.28624162
94	BRAF	0.27649920
95	PAK4	0.27082079
96	WNK3	0.26613460
97	MAPK9	0.25913741
98	CAMK2G	0.24752338
99	CDK3	0.24351206
100	STK38L	0.23643708

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	DNA replication_Homo sapiens_hsa03030	3.53467917
2	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	3.16974889
3	Mismatch repair_Homo sapiens_hsa03430	3.01062660
4	Spliceosome_Homo sapiens_hsa03040	3.00985165
5	Proteasome_Homo sapiens_hsa03050	2.93390472
6	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.83475984
7	Base excision repair_Homo sapiens_hsa03410	2.80959533
8	RNA transport_Homo sapiens_hsa03013	2.49713031
9	Nucleotide excision repair_Homo sapiens_hsa03420	2.45216496
10	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.43724367
11	Protein export_Homo sapiens_hsa03060	2.26319948
12	RNA polymerase_Homo sapiens_hsa03020	2.24338528
13	Steroid biosynthesis_Homo sapiens_hsa00100	2.19804686
14	Basal transcription factors_Homo sapiens_hsa03022	2.18151356
15	Non-homologous end-joining_Homo sapiens_hsa03450	2.06763155
16	Homologous recombination_Homo sapiens_hsa03440	2.02696008
17	Pyrimidine metabolism_Homo sapiens_hsa00240	2.00922717
18	Fatty acid elongation_Homo sapiens_hsa00062	1.95419588
19	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.92404796
20	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.82073976
21	Fanconi anemia pathway_Homo sapiens_hsa03460	1.74637825
22	Cell cycle_Homo sapiens_hsa04110	1.72839734
23	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.69405638
24	mRNA surveillance pathway_Homo sapiens_hsa03015	1.67586684
25	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.66463040
26	Folate biosynthesis_Homo sapiens_hsa00790	1.65786977
27	RNA degradation_Homo sapiens_hsa03018	1.61706874
28	One carbon pool by folate_Homo sapiens_hsa00670	1.58651249
29	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.58029857
30	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.56790944
31	Alcoholism_Homo sapiens_hsa05034	1.50030066
32	Oxidative phosphorylation_Homo sapiens_hsa00190	1.49652224
33	Parkinsons disease_Homo sapiens_hsa05012	1.46635416
34	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.46609856
35	Carbon metabolism_Homo sapiens_hsa01200	1.45296454
36	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	1.45057798
37	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.42911454
38	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.40093566
39	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.33428197
40	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	1.31948644
41	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.27423504
42	Huntingtons disease_Homo sapiens_hsa05016	1.26324399
43	Purine metabolism_Homo sapiens_hsa00230	1.19300405
44	Pentose phosphate pathway_Homo sapiens_hsa00030	1.17288769
45	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.16608675
46	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.16455546
47	Pyruvate metabolism_Homo sapiens_hsa00620	1.12283748
48	Shigellosis_Homo sapiens_hsa05131	1.09787836
49	Sulfur relay system_Homo sapiens_hsa04122	1.06895955
50	Propanoate metabolism_Homo sapiens_hsa00640	0.93805176
51	Vibrio cholerae infection_Homo sapiens_hsa05110	0.93269587
52	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.91855040
53	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.91129487
54	Selenocompound metabolism_Homo sapiens_hsa00450	0.90306097
55	Viral carcinogenesis_Homo sapiens_hsa05203	0.86257380
56	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.85488155
57	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.83218870
58	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.79155681
59	Oocyte meiosis_Homo sapiens_hsa04114	0.76992717
60	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.73859502
61	Metabolic pathways_Homo sapiens_hsa01100	0.64110876
62	Fatty acid metabolism_Homo sapiens_hsa01212	0.62488882
63	Regulation of autophagy_Homo sapiens_hsa04140	0.61699478
64	p53 signaling pathway_Homo sapiens_hsa04115	0.60151644
65	Alzheimers disease_Homo sapiens_hsa05010	0.57954287
66	Ribosome_Homo sapiens_hsa03010	0.56924439
67	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.55210303
68	Glutathione metabolism_Homo sapiens_hsa00480	0.53938027
69	Arginine and proline metabolism_Homo sapiens_hsa00330	0.53056772
70	Peroxisome_Homo sapiens_hsa04146	0.51004536
71	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.42193626
72	Herpes simplex infection_Homo sapiens_hsa05168	0.41523061
73	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.39475297
74	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.38965996
75	Galactose metabolism_Homo sapiens_hsa00052	0.38031955
76	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.36707662
77	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.36330822
78	Lysine degradation_Homo sapiens_hsa00310	0.29722467
79	Phenylalanine metabolism_Homo sapiens_hsa00360	0.29667676
80	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.28838457
81	Butanoate metabolism_Homo sapiens_hsa00650	0.28500428
82	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.27194783
83	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.27007629
84	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.26906428
85	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.25642565
86	Thyroid cancer_Homo sapiens_hsa05216	0.24156436
87	Collecting duct acid secretion_Homo sapiens_hsa04966	0.23824116
88	Primary immunodeficiency_Homo sapiens_hsa05340	0.23064698
89	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.21766012
90	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.20693727
91	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.18860408
92	Bladder cancer_Homo sapiens_hsa05219	0.16686277
93	Legionellosis_Homo sapiens_hsa05134	0.15020398
94	Caffeine metabolism_Homo sapiens_hsa00232	0.14967408
95	AMPK signaling pathway_Homo sapiens_hsa04152	0.14551784
96	Salmonella infection_Homo sapiens_hsa05132	0.13221691
97	beta-Alanine metabolism_Homo sapiens_hsa00410	0.12661951
98	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.10167023
99	Endocytosis_Homo sapiens_hsa04144	0.07065927
100	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.06961639

LSM12P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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