LSM14A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA topological change (GO:0006265)5.30218105
2mitotic sister chromatid cohesion (GO:0007064)4.62078496
3establishment of integrated proviral latency (GO:0075713)4.52979513
4regulation of sister chromatid cohesion (GO:0007063)4.40852678
5negative regulation of mRNA metabolic process (GO:1903312)4.27343554
6formation of translation preinitiation complex (GO:0001731)4.23177062
7negative regulation of mRNA processing (GO:0050686)4.22802498
8mitotic chromosome condensation (GO:0007076)4.15720042
9nucleosome disassembly (GO:0006337)3.94224950
10protein-DNA complex disassembly (GO:0032986)3.94224950
11nuclear pore complex assembly (GO:0051292)3.87134878
12histone H2B ubiquitination (GO:0033523)3.76287991
13negative regulation of histone methylation (GO:0031061)3.74446858
14DNA ligation (GO:0006266)3.73036234
15protein localization to kinetochore (GO:0034501)3.70259894
16regulation of RNA export from nucleus (GO:0046831)3.68904723
17mitotic metaphase plate congression (GO:0007080)3.67577655
18nuclear pore organization (GO:0006999)3.58722434
19ribosome assembly (GO:0042255)3.52683207
20protein localization to chromosome, centromeric region (GO:0071459)3.52057451
21histone H2A monoubiquitination (GO:0035518)3.49552390
22monoubiquitinated protein deubiquitination (GO:0035520)3.44831528
23pre-miRNA processing (GO:0031054)3.44696461
24V(D)J recombination (GO:0033151)3.41822609
25mRNA splice site selection (GO:0006376)3.40604754
26positive regulation of mitotic sister chromatid separation (GO:1901970)3.36903303
27positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.36903303
28positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.36903303
29positive regulation of chromosome segregation (GO:0051984)3.34792888
30mitotic nuclear envelope disassembly (GO:0007077)3.32248655
31metaphase plate congression (GO:0051310)3.30274886
32alternative mRNA splicing, via spliceosome (GO:0000380)3.30050145
33regulation of spindle organization (GO:0090224)3.29956715
34DNA strand elongation involved in DNA replication (GO:0006271)3.28926007
35sister chromatid segregation (GO:0000819)3.27861746
36regulation of DNA endoreduplication (GO:0032875)3.27509375
37RNA stabilization (GO:0043489)3.26212794
38mRNA stabilization (GO:0048255)3.26212794
39mRNA splicing, via spliceosome (GO:0000398)3.25748368
40RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)3.25748368
41protein complex localization (GO:0031503)3.24828311
42DNA unwinding involved in DNA replication (GO:0006268)3.24232759
43mitotic sister chromatid segregation (GO:0000070)3.21939992
44RNA splicing, via transesterification reactions (GO:0000375)3.20949532
45regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.19105090
46spliceosomal tri-snRNP complex assembly (GO:0000244)3.16534744
47regulation of mitotic spindle organization (GO:0060236)3.16301774
48paraxial mesoderm development (GO:0048339)3.14477660
49DNA strand elongation (GO:0022616)3.13993891
50heterochromatin organization (GO:0070828)3.13941840
51membrane disassembly (GO:0030397)3.12656718
52nuclear envelope disassembly (GO:0051081)3.12656718
53establishment of viral latency (GO:0019043)3.11487429
54protein localization to chromosome (GO:0034502)3.10128165
55regulation of transcription from RNA polymerase I promoter (GO:0006356)3.08388905
56cellular protein complex localization (GO:0034629)3.02528940
57mRNA transport (GO:0051028)3.02193181
58kinetochore organization (GO:0051383)3.01894995
593-UTR-mediated mRNA stabilization (GO:0070935)3.00449257
60establishment of chromosome localization (GO:0051303)2.99988682
61attachment of spindle microtubules to kinetochore (GO:0008608)2.99974331
62DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.92905191
63regulation of histone H3-K27 methylation (GO:0061085)2.90655311
64RNA export from nucleus (GO:0006405)2.87536164
65protein export from nucleus (GO:0006611)2.86640885
66regulation of nucleobase-containing compound transport (GO:0032239)2.86376988
67sister chromatid cohesion (GO:0007062)2.84092128
68chromatin assembly (GO:0031497)2.83949964
69chromatin assembly or disassembly (GO:0006333)2.83138744
70pore complex assembly (GO:0046931)2.80474482
71regulation of histone H3-K9 methylation (GO:0051570)2.80106770
72DNA conformation change (GO:0071103)2.79968122
73mRNA export from nucleus (GO:0006406)2.79926250
74termination of RNA polymerase II transcription (GO:0006369)2.77820232
75regulation of mRNA stability (GO:0043488)2.77735378
76nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.74812538
77regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.74605972
78gene silencing by RNA (GO:0031047)2.74472742
79establishment of RNA localization (GO:0051236)2.74303194
80nucleic acid transport (GO:0050657)2.74303194
81RNA transport (GO:0050658)2.74303194
82regulation of centriole replication (GO:0046599)2.73502033
83regulation of DNA damage checkpoint (GO:2000001)2.72758973
84negative regulation of fibroblast apoptotic process (GO:2000270)2.71906143
85meiotic chromosome segregation (GO:0045132)2.71739330
86telomere maintenance via semi-conservative replication (GO:0032201)2.71259519
87nuclear envelope organization (GO:0006998)2.71007731
88regulation of RNA stability (GO:0043487)2.70680809
89negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.68101873
90corticosteroid receptor signaling pathway (GO:0031958)2.67977875
91glucocorticoid receptor signaling pathway (GO:0042921)2.66158912
92DNA replication-dependent nucleosome assembly (GO:0006335)2.65565855
93DNA replication-dependent nucleosome organization (GO:0034723)2.65565855
94NLS-bearing protein import into nucleus (GO:0006607)2.64655220
95regulation of hippo signaling (GO:0035330)2.64294170
96mRNA 3-end processing (GO:0031124)2.63901927
97double-strand break repair via nonhomologous end joining (GO:0006303)2.63339633
98non-recombinational repair (GO:0000726)2.63339633
99regulation of NFAT protein import into nucleus (GO:0051532)2.63028797
100histone H2A ubiquitination (GO:0033522)2.60217273
101growth hormone receptor signaling pathway (GO:0060396)2.57081819
102regulation of chromosome segregation (GO:0051983)2.56815811
103DNA duplex unwinding (GO:0032508)2.56096962
104DNA replication-independent nucleosome organization (GO:0034724)2.55641286
105DNA replication-independent nucleosome assembly (GO:0006336)2.55641286
106DNA damage response, signal transduction resulting in transcription (GO:0042772)2.53805157
107regulation of gene silencing by RNA (GO:0060966)2.52919780
108regulation of posttranscriptional gene silencing (GO:0060147)2.52919780
109regulation of gene silencing by miRNA (GO:0060964)2.52919780
110chromosome segregation (GO:0007059)2.52467582
111DNA geometric change (GO:0032392)2.52349319
112DNA damage induced protein phosphorylation (GO:0006975)2.51740892
113negative regulation of histone modification (GO:0031057)2.51260010
114DNA replication checkpoint (GO:0000076)2.50992068
115regulation of telomere maintenance via telomerase (GO:0032210)2.49389508
116kinetochore assembly (GO:0051382)2.49182773
117positive regulation of SMAD protein import into nucleus (GO:0060391)2.48329416
118trophectodermal cell differentiation (GO:0001829)2.47451570
119response to UV-C (GO:0010225)2.45489057
120folic acid-containing compound biosynthetic process (GO:0009396)2.43328146
121histone H3-K9 demethylation (GO:0033169)2.41923223
122dosage compensation (GO:0007549)2.37831392
123chromosome condensation (GO:0030261)2.37483894
124chromatin remodeling at centromere (GO:0031055)2.37465521
125gene silencing (GO:0016458)2.37172441
126negative regulation of chromatin modification (GO:1903309)2.37164548
127regulation of stem cell maintenance (GO:2000036)2.36866826
128histone H3-K36 demethylation (GO:0070544)2.36740845
129histone lysine demethylation (GO:0070076)2.36692416
130CENP-A containing nucleosome assembly (GO:0034080)2.36687155
131ATP-dependent chromatin remodeling (GO:0043044)2.36187002
132negative regulation of RNA splicing (GO:0033119)2.35734148
133negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.35524839
134positive regulation of gene expression, epigenetic (GO:0045815)2.35122863
135DNA replication initiation (GO:0006270)2.34037854
136regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.32658587
137regulation of chromatin silencing (GO:0031935)2.31843439
138regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.31782930
139endothelial tube morphogenesis (GO:0061154)2.29785007
140morphogenesis of an endothelium (GO:0003159)2.29785007
141protein K6-linked ubiquitination (GO:0085020)2.29410463
142histone demethylation (GO:0016577)2.29345726
143embryonic process involved in female pregnancy (GO:0060136)2.29314813
144* cytoplasmic mRNA processing body assembly (GO:0033962)2.29163251

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.44064345
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.76869549
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.66566007
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.58002332
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.43006775
6RBPJ_22232070_ChIP-Seq_NCS_Mouse3.40175845
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.28083757
8* MYC_22102868_ChIP-Seq_BL_Human3.19708597
9HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.71185387
10FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.35683695
11SALL1_21062744_ChIP-ChIP_HESCs_Human2.30747796
12AR_21909140_ChIP-Seq_LNCAP_Human2.28456280
13KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.22878089
14KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.22878089
15KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.22878089
16* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.16240072
17E2F1_21310950_ChIP-Seq_MCF-7_Human2.10350784
18STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.07716149
19YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.02338949
20VDR_21846776_ChIP-Seq_THP-1_Human2.01602418
21MYC_18555785_ChIP-Seq_MESCs_Mouse1.95416497
22TP63_19390658_ChIP-ChIP_HaCaT_Human1.92771051
23TCF7_22412390_ChIP-Seq_EML_Mouse1.92696013
24PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.88718806
25STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.81758326
26PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.81378189
27* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.77820227
28WT1_19549856_ChIP-ChIP_CCG9911_Human1.75341445
29KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.73807027
30MYC_19079543_ChIP-ChIP_MESCs_Mouse1.66431967
31CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.64256178
32SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.63759413
33ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.62120556
34CREB1_15753290_ChIP-ChIP_HEK293T_Human1.61618205
35KDM2B_26808549_Chip-Seq_DND41_Human1.61238735
36TP63_17297297_ChIP-ChIP_HaCaT_Human1.61162251
37* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.60255557
38KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.60093622
39UTX_26944678_Chip-Seq_JUKART_Human1.59749680
40* MAF_26560356_Chip-Seq_TH1_Human1.57546724
41ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.57290905
42* TTF2_22483619_ChIP-Seq_HELA_Human1.55167523
43MYB_26560356_Chip-Seq_TH2_Human1.52133031
44TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.50656250
45* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.49065986
46MYB_26560356_Chip-Seq_TH1_Human1.48336285
47FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.47541071
48CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.46542189
49EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.37886698
50TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.37683807
51* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.36872808
52NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.36107437
53PKCTHETA_26484144_Chip-Seq_BREAST_Human1.35996763
54MYB_21317192_ChIP-Seq_ERMYB_Mouse1.35823763
55PADI4_21655091_ChIP-ChIP_MCF-7_Human1.33446408
56ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.31734238
57CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.31696814
58CIITA_25753668_ChIP-Seq_RAJI_Human1.30890800
59SOX2_18555785_ChIP-Seq_MESCs_Mouse1.30811338
60KDM5A_27292631_Chip-Seq_BREAST_Human1.29619485
61RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.28715095
62KLF4_18555785_ChIP-Seq_MESCs_Mouse1.28457264
63* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.27560700
64CHD1_26751641_Chip-Seq_LNCaP_Human1.27233881
65WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.27214126
66NANOG_21062744_ChIP-ChIP_HESCs_Human1.26690996
67FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.25424065
68KDM2B_26808549_Chip-Seq_JURKAT_Human1.23638538
69CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.22449461
70STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.21835657
71ELK1_19687146_ChIP-ChIP_HELA_Human1.21484403
72TCF3_18692474_ChIP-Seq_MEFs_Mouse1.21354815
73* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.21023322
74HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.20868374
75MYC_19030024_ChIP-ChIP_MESCs_Mouse1.20800228
76ELK3_25401928_ChIP-Seq_HUVEC_Human1.19625689
77FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.19297878
78SCL_19346495_ChIP-Seq_HPC-7_Human1.19058669
79TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.17623588
80E2F1_18555785_ChIP-Seq_MESCs_Mouse1.17548336
81FOXP3_21729870_ChIP-Seq_TREG_Human1.17411611
82* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.16938414
83NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.16623645
84BRD4_27068464_Chip-Seq_AML-cells_Mouse1.16063192
85HIF1A_21447827_ChIP-Seq_MCF-7_Human1.15353836
86ATF3_27146783_Chip-Seq_COLON_Human1.14845460
87VDR_24763502_ChIP-Seq_THP-1_Human1.14022690
88HOXB4_20404135_ChIP-ChIP_EML_Mouse1.13512726
89THAP11_20581084_ChIP-Seq_MESCs_Mouse1.11630566
90ERG_20887958_ChIP-Seq_HPC-7_Mouse1.11555806
91KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.11353409
92* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.10356430
93* NCOR1_26117541_ChIP-Seq_K562_Human1.09841744
94KDM2B_26808549_Chip-Seq_SUP-B15_Human1.08983749
95SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.08918548
96FOXO3_23340844_ChIP-Seq_DLD1_Human1.07988018
97STAT6_21828071_ChIP-Seq_BEAS2B_Human1.07979522
98SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.07415856
99MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.06323335
100SPI1_23547873_ChIP-Seq_NB4_Human1.05673626
101SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.05399241
102XRN2_22483619_ChIP-Seq_HELA_Human1.05208661
103ELF1_17652178_ChIP-ChIP_JURKAT_Human1.05047950
104NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.04824586
105NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.04265040
106DCP1A_22483619_ChIP-Seq_HELA_Human1.03637140
107* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.02995074
108NANOG_18555785_ChIP-Seq_MESCs_Mouse1.02072350
109TFEB_21752829_ChIP-Seq_HELA_Human1.01694294
110P300_27058665_Chip-Seq_ZR-75-30cells_Human1.01635902
111RUNX1_22412390_ChIP-Seq_EML_Mouse1.01235470
112ZFX_18555785_ChIP-Seq_MESCs_Mouse1.00276973
113CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.99773558
114ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.99638304
115ZFP281_18757296_ChIP-ChIP_E14_Mouse0.99017934
116* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.98922819
117SOX17_20123909_ChIP-Seq_XEN_Mouse0.98723933
118E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.97734442
119* UBF1/2_26484160_Chip-Seq_HMECs_Human0.96067412
120MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.95590312
121SALL4_18804426_ChIP-ChIP_XEN_Mouse0.95532679
122GABP_19822575_ChIP-Seq_HepG2_Human0.95247264
123TCF3_18692474_ChIP-Seq_MESCs_Mouse0.93897140
124SOX2_16153702_ChIP-ChIP_HESCs_Human0.93867067
125* RUNX_20019798_ChIP-Seq_JUKART_Human0.93786032
126MAF_26560356_Chip-Seq_TH2_Human0.93487837
127* GATA6_25053715_ChIP-Seq_YYC3_Human0.93439304
128NANOG_16153702_ChIP-ChIP_HESCs_Human0.92986408
129* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.92915783
130SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.92842016
131SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.91810330
132SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.91515439
133POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.91407454
134TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.90904250
135* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.90333850
136KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.90270949
137EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.89655550
138VDR_23849224_ChIP-Seq_CD4+_Human0.89571051
139GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.89463021
140KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.88447679
141TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.88315585
142TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.88055745
143SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.87977858
144CLOCK_20551151_ChIP-Seq_293T_Human0.87933626
145FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.86936298

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication2.77342522
2MP0010094_abnormal_chromosome_stability2.73364751
3MP0010352_gastrointestinal_tract_polyps2.65784076
4MP0003693_abnormal_embryo_hatching2.56369233
5MP0004957_abnormal_blastocyst_morpholog2.54826690
6MP0003077_abnormal_cell_cycle2.53777717
7MP0005076_abnormal_cell_differentiation2.52045414
8MP0003111_abnormal_nucleus_morphology2.51309893
9MP0002396_abnormal_hematopoietic_system2.22969962
10MP0009672_abnormal_birth_weight2.13878335
11MP0003705_abnormal_hypodermis_morpholog2.13041297
12MP0004185_abnormal_adipocyte_glucose2.08000671
13MP0000350_abnormal_cell_proliferation1.86772353
14MP0001188_hyperpigmentation1.84080725
15MP0001730_embryonic_growth_arrest1.83052303
16MP0010234_abnormal_vibrissa_follicle1.79553443
17MP0003303_peritoneal_inflammation1.78797442
18MP0008007_abnormal_cellular_replicative1.73266569
19MP0003300_gastrointestinal_ulcer1.72324839
20MP0010307_abnormal_tumor_latency1.69872658
21MP0009278_abnormal_bone_marrow1.68157567
22MP0002796_impaired_skin_barrier1.66956591
23MP0002697_abnormal_eye_size1.62050207
24MP0000733_abnormal_muscle_development1.61608149
25MP0002084_abnormal_developmental_patter1.58024808
26MP0002877_abnormal_melanocyte_morpholog1.56512871
27MP0003566_abnormal_cell_adhesion1.55722661
28MP0001697_abnormal_embryo_size1.55470882
29MP0004808_abnormal_hematopoietic_stem1.55046302
30MP0005380_embryogenesis_phenotype1.53833764
31MP0001672_abnormal_embryogenesis/_devel1.53833764
32MP0002085_abnormal_embryonic_tissue1.50673557
33MP0002086_abnormal_extraembryonic_tissu1.50406360
34MP0005501_abnormal_skin_physiology1.49900919
35MP0003763_abnormal_thymus_physiology1.49316655
36MP0003221_abnormal_cardiomyocyte_apopto1.48173426
37MP0000490_abnormal_crypts_of1.46108961
38MP0003984_embryonic_growth_retardation1.43142599
39MP0002088_abnormal_embryonic_growth/wei1.41548279
40MP0004197_abnormal_fetal_growth/weight/1.34312865
41MP0001286_abnormal_eye_development1.32851970
42MP0001915_intracranial_hemorrhage1.31927323
43MP0005397_hematopoietic_system_phenotyp1.31636050
44MP0001545_abnormal_hematopoietic_system1.31636050
45MP0001849_ear_inflammation1.31342493
46MP0003453_abnormal_keratinocyte_physiol1.31116862
47MP0002092_abnormal_eye_morphology1.28221576
48MP0003567_abnormal_fetal_cardiomyocyte1.26749156
49MP0003123_paternal_imprinting1.25768034
50MP0008932_abnormal_embryonic_tissue1.24680220
51MP0002006_tumorigenesis1.24457756
52MP0002019_abnormal_tumor_incidence1.23104128
53MP0004264_abnormal_extraembryonic_tissu1.22781692
54MP0008877_abnormal_DNA_methylation1.20312552
55MP0003122_maternal_imprinting1.19512289
56MP0002398_abnormal_bone_marrow1.19488745
57MP0003121_genomic_imprinting1.19382290
58MP0002080_prenatal_lethality1.16800775
59MP0003890_abnormal_embryonic-extraembry1.14689539
60MP0006054_spinal_hemorrhage1.13625686
61MP0000703_abnormal_thymus_morphology1.13297641
62MP0005023_abnormal_wound_healing1.12012778
63MP0009053_abnormal_anal_canal1.11881487
64MP0003115_abnormal_respiratory_system1.10609513
65MP0009333_abnormal_splenocyte_physiolog1.07143879
66MP0003828_pulmonary_edema1.07139053
67MP0008058_abnormal_DNA_repair1.06723817
68MP0002925_abnormal_cardiovascular_devel1.06715402
69MP0003787_abnormal_imprinting1.05309972
70MP0002233_abnormal_nose_morphology1.05000766
71MP0000537_abnormal_urethra_morphology1.04327476
72MP0002111_abnormal_tail_morphology1.03838798
73MP0001800_abnormal_humoral_immune1.03213687
74MP0003937_abnormal_limbs/digits/tail_de1.03192286
75MP0002166_altered_tumor_susceptibility1.02711281
76MP0000685_abnormal_immune_system1.01471713
77MP0003861_abnormal_nervous_system1.01186767
78MP0001851_eye_inflammation1.00042244
79MP0000566_synostosis0.99765151
80MP0003385_abnormal_body_wall0.97515421
81MP0003315_abnormal_perineum_morphology0.97321909
82MP0002722_abnormal_immune_system0.96540689
83MP0003448_altered_tumor_morphology0.94358586
84MP0002009_preneoplasia0.93836831
85MP0010678_abnormal_skin_adnexa0.93348075
86MP0010368_abnormal_lymphatic_system0.92768507
87MP0003091_abnormal_cell_migration0.92371311
88MP0005384_cellular_phenotype0.92054458
89MP0003119_abnormal_digestive_system0.91689342
90MP0000465_gastrointestinal_hemorrhage0.91221168
91MP0002405_respiratory_system_inflammati0.89887252
92MP0003935_abnormal_craniofacial_develop0.88767791
93MP0000689_abnormal_spleen_morphology0.88619479
94MP0002653_abnormal_ependyma_morphology0.88362013
95MP0000313_abnormal_cell_death0.87801871
96MP0000432_abnormal_head_morphology0.87662085
97MP0002452_abnormal_antigen_presenting0.86536804
98MP0000428_abnormal_craniofacial_morphol0.86145370
99MP0005248_abnormal_Harderian_gland0.86023788
100MP0002081_perinatal_lethality0.85177539
101MP0010155_abnormal_intestine_physiology0.85017440
102MP0005377_hearing/vestibular/ear_phenot0.84465446
103MP0003878_abnormal_ear_physiology0.84465446
104MP0009379_abnormal_foot_pigmentation0.84269249
105MP0000716_abnormal_immune_system0.83974962
106MP0001293_anophthalmia0.83830592
107MP0005621_abnormal_cell_physiology0.82686702
108MP0000767_abnormal_smooth_muscle0.81765532
109MP0005666_abnormal_adipose_tissue0.81019862
110MP0003718_maternal_effect0.80362807
111MP0005451_abnormal_body_composition0.80200354
112MP0003943_abnormal_hepatobiliary_system0.79971986
113MP0001727_abnormal_embryo_implantation0.79936749
114MP0002429_abnormal_blood_cell0.79686408
115MP0009703_decreased_birth_body0.79676001
116MP0001879_abnormal_lymphatic_vessel0.79586103
117MP0002420_abnormal_adaptive_immunity0.78708522
118MP0004782_abnormal_surfactant_physiolog0.78622486
119MP0003941_abnormal_skin_development0.78374958
120MP0001819_abnormal_immune_cell0.78236887
121MP0010630_abnormal_cardiac_muscle0.78183309
122MP0001784_abnormal_fluid_regulation0.77555956
123MP0003950_abnormal_plasma_membrane0.75973109
124MP0000858_altered_metastatic_potential0.75816407
125MP0006292_abnormal_olfactory_placode0.75558796
126MP0003755_abnormal_palate_morphology0.74371216
127MP0000377_abnormal_hair_follicle0.73800750
128MP0010030_abnormal_orbit_morphology0.73445278
129MP0002114_abnormal_axial_skeleton0.73391249
130MP0000477_abnormal_intestine_morphology0.73275456
131MP0002116_abnormal_craniofacial_bone0.71903146
132MP0000762_abnormal_tongue_morphology0.71511990
133MP0003938_abnormal_ear_development0.66858192

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the fingertips (HP:0001211)3.92207262
2Volvulus (HP:0002580)3.52765048
3Vertebral arch anomaly (HP:0008438)3.02192222
4Facial hemangioma (HP:0000329)2.77088185
5Acute myeloid leukemia (HP:0004808)2.73001189
6High anterior hairline (HP:0009890)2.67344586
7Short 4th metacarpal (HP:0010044)2.65961865
8Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.65961865
9Multiple enchondromatosis (HP:0005701)2.55689554
10Nephroblastoma (Wilms tumor) (HP:0002667)2.53622328
11Ependymoma (HP:0002888)2.52010781
12Deviation of the thumb (HP:0009603)2.49321863
13Proximal placement of thumb (HP:0009623)2.48533375
14Malignant gastrointestinal tract tumors (HP:0006749)2.42841299
15Gastrointestinal carcinoma (HP:0002672)2.42841299
16Hepatoblastoma (HP:0002884)2.38119284
17Spastic diplegia (HP:0001264)2.36941972
18Missing ribs (HP:0000921)2.36112836
19Long eyelashes (HP:0000527)2.35493385
20Insidious onset (HP:0003587)2.30611156
21Termporal pattern (HP:0011008)2.30611156
22Embryonal renal neoplasm (HP:0011794)2.28970517
23Pelvic girdle muscle weakness (HP:0003749)2.28200931
24Calcaneovalgus deformity (HP:0001848)2.26818673
25Basal cell carcinoma (HP:0002671)2.25288162
26Increased nuchal translucency (HP:0010880)2.23204566
27Rectal prolapse (HP:0002035)2.22506845
28Shoulder girdle muscle weakness (HP:0003547)2.21409410
29Coarctation of aorta (HP:0001680)2.21312836
30Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.18651579
31Neoplasm of the oral cavity (HP:0100649)2.17799382
32Lip pit (HP:0100267)2.17795799
33Subaortic stenosis (HP:0001682)2.17121970
34Abnormality of the left ventricular outflow tract (HP:0011103)2.17121970
35Birth length less than 3rd percentile (HP:0003561)2.16057481
36Hematochezia (HP:0002573)2.15238971
37Asymmetry of the thorax (HP:0001555)2.15136603
38Subacute progressive viral hepatitis (HP:0006572)2.13985336
39Biliary tract neoplasm (HP:0100574)2.13830414
40Male infertility (HP:0003251)2.13063819
41Rhabdomyosarcoma (HP:0002859)2.09521573
42Blepharitis (HP:0000498)2.09141243
43Patellar aplasia (HP:0006443)2.08824380
44Chromsome breakage (HP:0040012)2.08725683
45Cystic hygroma (HP:0000476)2.06154310
46Colon cancer (HP:0003003)2.04458658
47Genu recurvatum (HP:0002816)2.03984507
48Short middle phalanx of the 5th finger (HP:0004220)2.03955968
49Obsessive-compulsive behavior (HP:0000722)2.03626956
50Transitional cell carcinoma of the bladder (HP:0006740)2.03301941
51Deep palmar crease (HP:0006191)2.02615353
52Curly hair (HP:0002212)2.01761623
53Medulloblastoma (HP:0002885)2.00858182
54Abnormality of the 4th metacarpal (HP:0010012)2.00420913
55Neonatal short-limb short stature (HP:0008921)1.99460061
56Papillary thyroid carcinoma (HP:0002895)1.96571161
57Abnormality of the musculature of the pelvis (HP:0001469)1.95422634
58Abnormality of the hip-girdle musculature (HP:0001445)1.95422634
59Back pain (HP:0003418)1.94473327
60Omphalocele (HP:0001539)1.94236729
61Abnormality of the astrocytes (HP:0100707)1.93834589
62Astrocytoma (HP:0009592)1.93834589
63Ectopic kidney (HP:0000086)1.93752298
64Cellulitis (HP:0100658)1.93717195
65Pseudobulbar signs (HP:0002200)1.93677430
66Pendular nystagmus (HP:0012043)1.92805048
67Sandal gap (HP:0001852)1.92054425
68Aplasia/Hypoplasia of the patella (HP:0006498)1.91545655
69Leiomyosarcoma (HP:0100243)1.90804760
70Uterine leiomyosarcoma (HP:0002891)1.90804760
71Shallow orbits (HP:0000586)1.90036720
72Bladder neoplasm (HP:0009725)1.89990402
73Bladder carcinoma (HP:0002862)1.89990402
74Broad long bones (HP:0005622)1.89921560
75Cortical dysplasia (HP:0002539)1.89811179
76Neoplasm of striated muscle (HP:0009728)1.89496308
77Ankyloglossia (HP:0010296)1.88978421
78Sparse lateral eyebrow (HP:0005338)1.88900661
79Breech presentation (HP:0001623)1.87863697
80Long clavicles (HP:0000890)1.86338319
81Prominent nose (HP:0000448)1.85357600
82Radioulnar synostosis (HP:0002974)1.83981123
83T lymphocytopenia (HP:0005403)1.83226755
84Cubitus valgus (HP:0002967)1.82908878
85Atresia of the external auditory canal (HP:0000413)1.82907762
86Recurrent viral infections (HP:0004429)1.82856583
87Rib fusion (HP:0000902)1.82377266
88Overlapping toe (HP:0001845)1.82232708
89Cerebral aneurysm (HP:0004944)1.81906469
90Metaphyseal cupping (HP:0003021)1.81547671
91Progressive external ophthalmoplegia (HP:0000590)1.80919113
92Increased density of long bones (HP:0006392)1.80861590
93Myelodysplasia (HP:0002863)1.79228421
94Aortic aneurysm (HP:0004942)1.79203771
95Broad thumb (HP:0011304)1.78466418
96Deformed tarsal bones (HP:0008119)1.77926269
97Neoplasm of the small intestine (HP:0100833)1.77883272
98Heterotopia (HP:0002282)1.77729999
99Ulnar bowing (HP:0003031)1.77592021
100Posterior subcapsular cataract (HP:0007787)1.75897844
101Abnormality of the parietal bone (HP:0002696)1.75331103
102Abnormality of chromosome segregation (HP:0002916)1.75269305
103Disinhibition (HP:0000734)1.75001926
104Uterine neoplasm (HP:0010784)1.74801838
105Cutis marmorata (HP:0000965)1.74231523
106Thyroid carcinoma (HP:0002890)1.73997956
107Mitral valve prolapse (HP:0001634)1.73769381
108Deep philtrum (HP:0002002)1.73312926
109Embryonal neoplasm (HP:0002898)1.72585377
110Spinal cord lesions (HP:0100561)1.71361642
111Syringomyelia (HP:0003396)1.71361642
112Ankle contracture (HP:0006466)1.70942605
113Supernumerary ribs (HP:0005815)1.70357759
114Broad palm (HP:0001169)1.69656283
115Abnormality of T cell number (HP:0011839)1.69632864
116Abnormality of chromosome stability (HP:0003220)1.68424306
117Broad phalanges of the hand (HP:0009768)1.67962987
118Abnormal hair whorl (HP:0010721)1.67850192
119Selective tooth agenesis (HP:0001592)1.67220447
120Trigonocephaly (HP:0000243)1.67016567
121Protrusio acetabuli (HP:0003179)1.66784736
122Spondylolisthesis (HP:0003302)1.66763172
123Abnormality of lateral ventricle (HP:0030047)1.65813660
124Autoimmune thrombocytopenia (HP:0001973)1.65353278
125Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.65110116
126Truncal obesity (HP:0001956)1.64648636
127Viral hepatitis (HP:0006562)1.64512165
128Bicuspid aortic valve (HP:0001647)1.64056103
129Abnormality of the phalanges of the hallux (HP:0010057)1.63608076
130Neoplasm of the colon (HP:0100273)1.63358513
131Acute lymphatic leukemia (HP:0006721)1.62541605
132Absent eyebrow (HP:0002223)1.61869065
133Arnold-Chiari malformation (HP:0002308)1.61527617
134Cafe-au-lait spot (HP:0000957)1.61141428
135High pitched voice (HP:0001620)1.60590870
136Hyperacusis (HP:0010780)1.60450776
137Aplasia involving bones of the extremities (HP:0009825)1.60419622
138Aplasia involving bones of the upper limbs (HP:0009823)1.60419622
139Aplasia of the phalanges of the hand (HP:0009802)1.60419622
140Limited elbow extension (HP:0001377)1.60305932
141Skull defect (HP:0001362)1.59734325
142Irregular epiphyses (HP:0010582)1.58780477
143Broad finger (HP:0001500)1.58658204
144Aplasia/Hypoplasia of the sternum (HP:0006714)1.58565639
145Abnormality of the peritoneum (HP:0002585)1.58518816
146Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.58506096
147Short 1st metacarpal (HP:0010034)1.58506096
148Low anterior hairline (HP:0000294)1.58389213
149Abnormality of the calcaneus (HP:0008364)1.57377886
150Neuroblastic tumors (HP:0004376)1.57353257
151Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.57353257
152Neuroblastoma (HP:0003006)1.57353257
153Primitive neuroectodermal tumor (HP:0030065)1.57353257
154Overriding aorta (HP:0002623)1.57202723
155Chromosomal breakage induced by crosslinking agents (HP:0003221)1.56480399
156Supernumerary bones of the axial skeleton (HP:0009144)1.56176850
157Amaurosis fugax (HP:0100576)1.54866892
158Shawl scrotum (HP:0000049)1.53939368
159Chin dimple (HP:0010751)1.53674787
160Breast hypoplasia (HP:0003187)1.52158485
161Abnormal number of incisors (HP:0011064)1.51815428
162Oligodactyly (HP:0012165)1.50763271

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS13.88585571
2CDK123.77022564
3CDC73.72332367
4EEF2K3.14496058
5TNIK2.80548202
6STK102.72301123
7PKN22.46309520
8NEK22.37598261
9TRIB32.34108423
10STK32.00688672
11MAP3K101.98403868
12RPS6KA41.97504574
13LATS21.95395473
14MAP3K61.89628706
15PNCK1.87313339
16CDK61.79610749
17DMPK1.77640673
18MAP4K11.77180485
19PASK1.76209406
20TTK1.75090137
21TAF11.70031782
22CDK91.63336262
23TAOK31.55448207
24SMG11.54288525
25BCR1.49857448
26RPS6KB21.48425135
27LRRK21.45345897
28SIK31.43600894
29YES11.43492497
30CDK41.42889477
31MAP3K81.38218199
32MELK1.29809326
33PRPF4B1.28539130
34PLK31.25226393
35CDK71.23822697
36JAK31.22323892
37BRD41.21439768
38PLK41.15699100
39TAOK11.13790077
40CHEK21.12949255
41BUB11.09088778
42NLK1.08730955
43STK41.06276846
44PIM11.01606973
45ALK1.01339547
46HIPK21.00882877
47CDK31.00485262
48TYRO31.00169747
49TSSK60.99663716
50EIF2AK10.99097064
51CHEK10.98475639
52AURKB0.95957346
53MAP3K140.94439931
54KSR10.94014519
55PDGFRA0.92277828
56MTOR0.88762688
57MKNK10.88121394
58PRKD20.87137546
59PLK10.86786592
60STK38L0.86414375
61MOS0.85471861
62NTRK10.84977589
63DYRK30.83117107
64MAP3K130.82219172
65KSR20.82100121
66WEE10.81102603
67TRIM280.79432901
68NEK90.78569965
69ATM0.78241593
70ATR0.77278415
71CDK80.77201688
72MKNK20.76070506
73BMX0.73741937
74PAK40.73229415
75PDGFRB0.72943839
76FLT30.72684102
77FGFR30.71799034
78PTK60.71172380
79RET0.70660193
80ICK0.69053220
81CHUK0.67376095
82FGFR10.66296901
83MAP2K20.65603989
84CAMK1D0.65501069
85ITK0.64890432
86TTN0.64586801
87CDK20.64246012
88CSK0.63288621
89CSNK1E0.61666125
90SRPK10.60831966
91ZAP700.59308083
92STK240.58634925
93FGFR40.57793935
94MAP3K90.57596198
95RAF10.57362879
96MAP3K50.57175416
97TGFBR10.56444952
98BTK0.56206304
99TYK20.55485419
100NEK10.55193629
101MARK30.53974891
102CLK10.53830729
103BRSK20.52917988
104BLK0.51787936
105CSNK1D0.51230446
106CDK190.51162676
107PAK20.50347958
108MAPK100.49932958
109TRPM70.49311121
110ERBB40.48339325
111KDR0.47865776
112ARAF0.47317090
113CSNK1G10.47132042
114SCYL20.45407171
115ABL10.45267599
116CDK10.44342112
117TGFBR20.44000847
118CAMK1G0.43936362
119DYRK1B0.40699312
120WNK10.40586405
121JAK20.40295719
122EIF2AK30.39878186
123EIF2AK20.39790484
124PRKDC0.38645520
125EPHB10.38564373
126FGR0.38288367
127RIPK10.38268804
128VRK20.37605129
129MAP2K30.37506151
130RPS6KA10.37464542
131GSK3B0.37438611
132MAPK110.36991513
133CSNK2A20.36622816
134NUAK10.36451413
135MAPK10.36399800
136BRAF0.35654307
137MAPK140.34291808
138MAPK90.33533258
139ERBB30.32864026
140CDK11A0.30253732

Predicted pathways (KEGG)

RankGene SetZ-score
1Cell cycle_Homo sapiens_hsa041102.51401698
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.33857531
3DNA replication_Homo sapiens_hsa030302.07147716
4Mismatch repair_Homo sapiens_hsa034301.87747296
5RNA transport_Homo sapiens_hsa030131.78880284
6p53 signaling pathway_Homo sapiens_hsa041151.74719974
7MicroRNAs in cancer_Homo sapiens_hsa052061.73224921
8Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.72692489
9mRNA surveillance pathway_Homo sapiens_hsa030151.71911760
10Chronic myeloid leukemia_Homo sapiens_hsa052201.70446056
11Adherens junction_Homo sapiens_hsa045201.68426030
12Pancreatic cancer_Homo sapiens_hsa052121.66117265
13RNA degradation_Homo sapiens_hsa030181.63545459
14Small cell lung cancer_Homo sapiens_hsa052221.62691963
15Spliceosome_Homo sapiens_hsa030401.59703087
16Base excision repair_Homo sapiens_hsa034101.54371358
17TGF-beta signaling pathway_Homo sapiens_hsa043501.50046046
18mTOR signaling pathway_Homo sapiens_hsa041501.43851568
19Herpes simplex infection_Homo sapiens_hsa051681.43522520
20Colorectal cancer_Homo sapiens_hsa052101.42137234
21Homologous recombination_Homo sapiens_hsa034401.36909883
22B cell receptor signaling pathway_Homo sapiens_hsa046621.36195227
23Primary immunodeficiency_Homo sapiens_hsa053401.32344697
24Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.28900830
25Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.28429824
26Hippo signaling pathway_Homo sapiens_hsa043901.27886091
27Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.25482181
28HTLV-I infection_Homo sapiens_hsa051661.24875610
29Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.24794310
30Viral myocarditis_Homo sapiens_hsa054161.23988749
31Transcriptional misregulation in cancer_Homo sapiens_hsa052021.23061225
32Thyroid cancer_Homo sapiens_hsa052161.21919838
33Basal transcription factors_Homo sapiens_hsa030221.21733161
34Fanconi anemia pathway_Homo sapiens_hsa034601.21384994
35Non-homologous end-joining_Homo sapiens_hsa034501.20889341
36Prostate cancer_Homo sapiens_hsa052151.20289989
37Non-small cell lung cancer_Homo sapiens_hsa052231.19158194
38Leukocyte transendothelial migration_Homo sapiens_hsa046701.17527937
39Renal cell carcinoma_Homo sapiens_hsa052111.17262809
40Hepatitis B_Homo sapiens_hsa051611.16655148
41Antigen processing and presentation_Homo sapiens_hsa046121.15927874
42Notch signaling pathway_Homo sapiens_hsa043301.15206389
43Dorso-ventral axis formation_Homo sapiens_hsa043201.13536378
44Acute myeloid leukemia_Homo sapiens_hsa052211.13264555
45Viral carcinogenesis_Homo sapiens_hsa052031.12909768
46AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.11854079
47Nucleotide excision repair_Homo sapiens_hsa034201.10953654
48NF-kappa B signaling pathway_Homo sapiens_hsa040641.10424138
49Proteoglycans in cancer_Homo sapiens_hsa052051.08706370
50Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.08302932
51Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.06984795
52Endometrial cancer_Homo sapiens_hsa052131.06625908
53VEGF signaling pathway_Homo sapiens_hsa043701.04417377
54Leishmaniasis_Homo sapiens_hsa051401.02884618
55Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.01917661
56Measles_Homo sapiens_hsa051621.01611698
57Toxoplasmosis_Homo sapiens_hsa051451.01203488
58Osteoclast differentiation_Homo sapiens_hsa043801.00410668
59Shigellosis_Homo sapiens_hsa051310.98663197
60T cell receptor signaling pathway_Homo sapiens_hsa046600.97486561
61Jak-STAT signaling pathway_Homo sapiens_hsa046300.95855059
62Epstein-Barr virus infection_Homo sapiens_hsa051690.95661168
63Biosynthesis of amino acids_Homo sapiens_hsa012300.94550506
64Oocyte meiosis_Homo sapiens_hsa041140.94086678
65One carbon pool by folate_Homo sapiens_hsa006700.93647729
66Thyroid hormone signaling pathway_Homo sapiens_hsa049190.93094454
67Platelet activation_Homo sapiens_hsa046110.92269727
68Focal adhesion_Homo sapiens_hsa045100.92242266
69Basal cell carcinoma_Homo sapiens_hsa052170.92048076
70NOD-like receptor signaling pathway_Homo sapiens_hsa046210.91292088
71Bladder cancer_Homo sapiens_hsa052190.90782035
72Pathways in cancer_Homo sapiens_hsa052000.90700042
73Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.89085193
74Prolactin signaling pathway_Homo sapiens_hsa049170.89015211
75TNF signaling pathway_Homo sapiens_hsa046680.88428634
76FoxO signaling pathway_Homo sapiens_hsa040680.86967870
77Regulation of actin cytoskeleton_Homo sapiens_hsa048100.84714404
78Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.84408400
79Apoptosis_Homo sapiens_hsa042100.83896636
80Lysine degradation_Homo sapiens_hsa003100.83137554
81Insulin signaling pathway_Homo sapiens_hsa049100.78755730
82Tight junction_Homo sapiens_hsa045300.77518096
83Influenza A_Homo sapiens_hsa051640.77119121
84Wnt signaling pathway_Homo sapiens_hsa043100.75641522
85HIF-1 signaling pathway_Homo sapiens_hsa040660.74766020
86ErbB signaling pathway_Homo sapiens_hsa040120.74190865
87Hematopoietic cell lineage_Homo sapiens_hsa046400.74183869
88Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.73742192
89Neurotrophin signaling pathway_Homo sapiens_hsa047220.73242488
90Glioma_Homo sapiens_hsa052140.73140106
91Chemokine signaling pathway_Homo sapiens_hsa040620.72622611
92Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.70595493
93Toll-like receptor signaling pathway_Homo sapiens_hsa046200.69782852
94Intestinal immune network for IgA production_Homo sapiens_hsa046720.68143881
95Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.65042915
96Pentose phosphate pathway_Homo sapiens_hsa000300.64900640
97Selenocompound metabolism_Homo sapiens_hsa004500.64521441
98Longevity regulating pathway - mammal_Homo sapiens_hsa042110.64441718
99Melanoma_Homo sapiens_hsa052180.64233516
100Choline metabolism in cancer_Homo sapiens_hsa052310.63373445
101Cysteine and methionine metabolism_Homo sapiens_hsa002700.61966173
102Phototransduction_Homo sapiens_hsa047440.61749796
103Hedgehog signaling pathway_Homo sapiens_hsa043400.60669440
104PI3K-Akt signaling pathway_Homo sapiens_hsa041510.60545948
105ECM-receptor interaction_Homo sapiens_hsa045120.60453487
106Central carbon metabolism in cancer_Homo sapiens_hsa052300.60219235
107AMPK signaling pathway_Homo sapiens_hsa041520.59710657
108Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.58905007
109Long-term potentiation_Homo sapiens_hsa047200.58668853
110MAPK signaling pathway_Homo sapiens_hsa040100.58088673
111Ribosome_Homo sapiens_hsa030100.57781454
112Insulin resistance_Homo sapiens_hsa049310.57569272
113Melanogenesis_Homo sapiens_hsa049160.54682762
114Circadian rhythm_Homo sapiens_hsa047100.53921510
115Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.51386741
116Carbon metabolism_Homo sapiens_hsa012000.46508731
117Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.44167589
118Protein export_Homo sapiens_hsa030600.39910602
119Hepatitis C_Homo sapiens_hsa051600.38669823
120Inositol phosphate metabolism_Homo sapiens_hsa005620.38345459
121Sphingolipid signaling pathway_Homo sapiens_hsa040710.37903375
122Gap junction_Homo sapiens_hsa045400.37791567
123Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.36967049

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