LSM2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the LSm family of RNA-binding proteins. LSm proteins form stable heteromers that bind specifically to the 3'-terminal oligo(U) tract of U6 snRNA and may play a role in pre-mRNA splicing by mediating U4/U6 snRNP formation. Pseudogenes of this gene are located on the short arm of chromosomes 6 and 19. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.80893532
2ATP synthesis coupled proton transport (GO:0015986)5.40392227
3energy coupled proton transport, down electrochemical gradient (GO:0015985)5.40392227
4DNA deamination (GO:0045006)5.28007053
5ribosomal small subunit assembly (GO:0000028)4.96977169
6chaperone-mediated protein transport (GO:0072321)4.90146680
7DNA strand elongation involved in DNA replication (GO:0006271)4.89708288
8establishment of protein localization to mitochondrial membrane (GO:0090151)4.87149761
9telomere maintenance via semi-conservative replication (GO:0032201)4.82246690
10DNA strand elongation (GO:0022616)4.68105706
11protein complex biogenesis (GO:0070271)4.58168903
12DNA replication initiation (GO:0006270)4.48967781
13maturation of SSU-rRNA (GO:0030490)4.46599137
14mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.46503697
15viral transcription (GO:0019083)4.43498395
16translational termination (GO:0006415)4.34269985
17mitochondrial respiratory chain complex assembly (GO:0033108)4.33123996
18regulation of mitochondrial translation (GO:0070129)4.29403027
19mitochondrial respiratory chain complex I assembly (GO:0032981)4.29194829
20NADH dehydrogenase complex assembly (GO:0010257)4.29194829
21mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.29194829
22telomere maintenance via recombination (GO:0000722)4.26627171
23respiratory electron transport chain (GO:0022904)4.26394783
24ribosomal small subunit biogenesis (GO:0042274)4.21016456
25DNA replication checkpoint (GO:0000076)4.19927122
26electron transport chain (GO:0022900)4.16829158
27formation of translation preinitiation complex (GO:0001731)4.11023626
28kinetochore organization (GO:0051383)4.01908226
29mitotic recombination (GO:0006312)3.97281100
30kinetochore assembly (GO:0051382)3.96724771
31CENP-A containing nucleosome assembly (GO:0034080)3.95938492
32chromatin remodeling at centromere (GO:0031055)3.95874548
33translational elongation (GO:0006414)3.91773037
34ribosomal large subunit biogenesis (GO:0042273)3.91719302
35DNA unwinding involved in DNA replication (GO:0006268)3.89878135
36mitotic metaphase plate congression (GO:0007080)3.81409668
37translational initiation (GO:0006413)3.81366666
38telomere maintenance via telomere lengthening (GO:0010833)3.81225414
39pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.80934224
40ribonucleoprotein complex biogenesis (GO:0022613)3.80228730
41protein neddylation (GO:0045116)3.77593088
42oxidative phosphorylation (GO:0006119)3.75965946
43SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.74558653
44protein localization to kinetochore (GO:0034501)3.72907546
45protein targeting to membrane (GO:0006612)3.68894939
46nucleotide-excision repair, DNA gap filling (GO:0006297)3.68658592
47deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.68493474
48proteasome assembly (GO:0043248)3.66653150
49nucleobase biosynthetic process (GO:0046112)3.66637709
50ribosome biogenesis (GO:0042254)3.66177839
51cotranslational protein targeting to membrane (GO:0006613)3.64275439
52nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.63262608
53protein targeting to ER (GO:0045047)3.62617923
54protein targeting to mitochondrion (GO:0006626)3.61256036
55spliceosomal snRNP assembly (GO:0000387)3.61041292
56regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.59304079
57DNA replication-independent nucleosome organization (GO:0034724)3.55380268
58DNA replication-independent nucleosome assembly (GO:0006336)3.55380268
59protein localization to chromosome, centromeric region (GO:0071459)3.53086756
60purine nucleobase biosynthetic process (GO:0009113)3.46617368
61pseudouridine synthesis (GO:0001522)3.45758857
62DNA replication-dependent nucleosome organization (GO:0034723)3.45402663
63DNA replication-dependent nucleosome assembly (GO:0006335)3.45402663
64rRNA processing (GO:0006364)3.43750458
65establishment of protein localization to mitochondrion (GO:0072655)3.43534475
66mitotic nuclear envelope disassembly (GO:0007077)3.43000649
67protein localization to endoplasmic reticulum (GO:0070972)3.41637167
68establishment of protein localization to endoplasmic reticulum (GO:0072599)3.41562070
69cellular protein complex disassembly (GO:0043624)3.41092809
70pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.40095441
71viral life cycle (GO:0019058)3.39723738
72establishment of integrated proviral latency (GO:0075713)3.38537974
73metaphase plate congression (GO:0051310)3.36351154
74rRNA metabolic process (GO:0016072)3.32974133
75protein localization to mitochondrion (GO:0070585)3.32823561
76cytochrome complex assembly (GO:0017004)3.30780376
77histone exchange (GO:0043486)3.27967296
78ATP biosynthetic process (GO:0006754)3.23849282
79ribosome assembly (GO:0042255)3.23805131
80purine nucleoside triphosphate biosynthetic process (GO:0009145)3.23011737
81RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.22887397
82tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.22887397
83DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.22563945
84rRNA modification (GO:0000154)3.21947242
85purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.21665637
86respiratory chain complex IV assembly (GO:0008535)3.21135142
87deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.21007886
88translation (GO:0006412)3.20349739
89transcription-coupled nucleotide-excision repair (GO:0006283)3.20181382
90viral mRNA export from host cell nucleus (GO:0046784)3.18998673
91signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.17516071
92signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.17516071
93signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.17516071
94pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.17323788
95regulation of cellular amino acid metabolic process (GO:0006521)3.17070950
96positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.16654377
97* nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.15557692
98signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.15461790
99intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.15461790
100inner mitochondrial membrane organization (GO:0007007)3.14982800
101GTP biosynthetic process (GO:0006183)3.14750761
102regulation of nuclear cell cycle DNA replication (GO:0033262)3.13692540
103anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.12935343
104DNA damage response, detection of DNA damage (GO:0042769)3.12783139
105regulation of double-strand break repair via homologous recombination (GO:0010569)3.12223145
106protein complex disassembly (GO:0043241)3.12022383
107negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.11733817
108nuclear envelope disassembly (GO:0051081)3.10648156
109membrane disassembly (GO:0030397)3.10648156
110pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.10344126
111attachment of spindle microtubules to kinetochore (GO:0008608)3.10187552
112signal transduction involved in DNA damage checkpoint (GO:0072422)3.09978257
113signal transduction involved in DNA integrity checkpoint (GO:0072401)3.09978257
114IMP biosynthetic process (GO:0006188)3.09684333
115pyrimidine nucleotide catabolic process (GO:0006244)3.09248677
116spliceosomal complex assembly (GO:0000245)3.08276519
117peptidyl-histidine modification (GO:0018202)3.07486846
118base-excision repair, AP site formation (GO:0006285)3.07100731
119establishment of chromosome localization (GO:0051303)3.06903061
120regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.06105337
121mitotic sister chromatid segregation (GO:0000070)3.03464774
122folic acid-containing compound biosynthetic process (GO:0009396)2.99837021
123transcription elongation from RNA polymerase III promoter (GO:0006385)2.99711731
124termination of RNA polymerase III transcription (GO:0006386)2.99711731
125maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.99364853
126* nuclear-transcribed mRNA catabolic process (GO:0000956)2.97429960
127positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.97389615
128cellular component biogenesis (GO:0044085)2.96236509
129macromolecular complex disassembly (GO:0032984)2.95839694
130negative regulation of chromosome segregation (GO:0051985)2.94503651
131meiotic chromosome segregation (GO:0045132)2.92314348
132negative regulation of sister chromatid segregation (GO:0033046)2.90790386
133negative regulation of mitotic sister chromatid separation (GO:2000816)2.90790386
134negative regulation of mitotic sister chromatid segregation (GO:0033048)2.90790386
135negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.90790386
136G1/S transition of mitotic cell cycle (GO:0000082)2.90426005
137cell cycle G1/S phase transition (GO:0044843)2.90426005
138telomere organization (GO:0032200)2.87418566
139telomere maintenance (GO:0000723)2.87126466
140termination of RNA polymerase II transcription (GO:0006369)2.87031944
141negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.86242326
142negative regulation of ligase activity (GO:0051352)2.86242326
143spindle checkpoint (GO:0031577)2.84211366
144* exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.83527655
145spindle assembly checkpoint (GO:0071173)2.83493018
146* mRNA catabolic process (GO:0006402)2.82822177
147negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.82183751
148* RNA catabolic process (GO:0006401)2.81695550
149mitotic spindle assembly checkpoint (GO:0007094)2.80670679

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.89603955
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.47944797
3* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.83402594
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.78566216
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.60505567
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.35943084
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.26597928
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.11708707
9* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.04154777
10MYC_19079543_ChIP-ChIP_MESCs_Mouse3.03597656
11* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.02536548
12GABP_17652178_ChIP-ChIP_JURKAT_Human2.95472109
13* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.92164393
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.90808728
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.66666108
16MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.52437483
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.47394692
18XRN2_22483619_ChIP-Seq_HELA_Human2.42535841
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.33517709
20NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.32400638
21VDR_23849224_ChIP-Seq_CD4+_Human2.29102001
22ELF1_17652178_ChIP-ChIP_JURKAT_Human2.28678074
23* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.27952923
24SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.15756579
25E2F1_18555785_ChIP-Seq_MESCs_Mouse2.08131297
26DCP1A_22483619_ChIP-Seq_HELA_Human2.07851698
27FOXP3_21729870_ChIP-Seq_TREG_Human2.03367943
28* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.97493864
29HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.96231425
30TTF2_22483619_ChIP-Seq_HELA_Human1.94113149
31AR_21909140_ChIP-Seq_LNCAP_Human1.92728979
32* GABP_19822575_ChIP-Seq_HepG2_Human1.91687740
33E2F1_21310950_ChIP-Seq_MCF-7_Human1.89517201
34* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.86203269
35THAP11_20581084_ChIP-Seq_MESCs_Mouse1.83355929
36* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.83054925
37NANOG_18555785_ChIP-Seq_MESCs_Mouse1.74923622
38YY1_21170310_ChIP-Seq_MESCs_Mouse1.74536928
39* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.73338482
40POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.67109782
41MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.61882987
42* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.60313855
43CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.59670976
44ELK1_19687146_ChIP-ChIP_HELA_Human1.59040693
45FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.56096143
46E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.55159241
47ZFX_18555785_ChIP-Seq_MESCs_Mouse1.52891094
48CIITA_25753668_ChIP-Seq_RAJI_Human1.52487137
49ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.51444956
50* SRF_21415370_ChIP-Seq_HL-1_Mouse1.50613783
51* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.45803758
52YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.45733322
53* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.42283154
54CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.37756892
55SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.36636304
56MYC_22102868_ChIP-Seq_BL_Human1.35383313
57NOTCH1_21737748_ChIP-Seq_TLL_Human1.34582510
58TP63_19390658_ChIP-ChIP_HaCaT_Human1.32766481
59KDM5A_27292631_Chip-Seq_BREAST_Human1.32594741
60CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.32046761
61ERG_20887958_ChIP-Seq_HPC-7_Mouse1.30003308
62POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.29364691
63KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.23683893
64EGR1_19374776_ChIP-ChIP_THP-1_Human1.19446071
65STAT3_1855785_ChIP-Seq_MESCs_Mouse1.17941643
66SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.17391845
67E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.14798475
68DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.14079351
69* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.13362971
70KLF4_18555785_ChIP-Seq_MESCs_Mouse1.12846797
71CTCF_18555785_ChIP-Seq_MESCs_Mouse1.11241688
72* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.10855231
73KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.10554858
74IRF1_19129219_ChIP-ChIP_H3396_Human1.10529109
75MYC_18940864_ChIP-ChIP_HL60_Human1.09361250
76SOX2_18555785_ChIP-Seq_MESCs_Mouse1.09199304
77CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.07056308
78CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.05659190
79CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.05629875
80VDR_21846776_ChIP-Seq_THP-1_Human1.05180470
81POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.04406623
82PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.02981912
83ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.02556861
84TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.01656856
85PADI4_21655091_ChIP-ChIP_MCF-7_Human0.99887282
86TFEB_21752829_ChIP-Seq_HELA_Human0.98531184
87* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.98126523
88* FOXP1_21924763_ChIP-Seq_HESCs_Human0.97689492
89* SPI1_23547873_ChIP-Seq_NB4_Human0.97608861
90BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.97321278
91SOX2_16153702_ChIP-ChIP_HESCs_Human0.95684820
92RBPJ_22232070_ChIP-Seq_NCS_Mouse0.93515328
93* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.92516009
94* KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.92438034
95* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.90275837
96ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.90223864
97HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.87471660
98TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.86523176
99ELK1_22589737_ChIP-Seq_MCF10A_Human0.86339172
100* HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.85222181
101NANOG_16153702_ChIP-ChIP_HESCs_Human0.83359223
102* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.82417901
103DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.79675585
104SRY_22984422_ChIP-ChIP_TESTIS_Rat0.79024171
105SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.76740039
106TCF3_18692474_ChIP-Seq_MEFs_Mouse0.75892542
107POU5F1_16153702_ChIP-ChIP_HESCs_Human0.74778656
108* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.74752062
109CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.74618163
110OCT4_18692474_ChIP-Seq_MEFs_Mouse0.74582439
111* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.74521659
112* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.70769075
113TBX5_21415370_ChIP-Seq_HL-1_Mouse0.70656510
114PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.70633502
115FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.70626173
116* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.70349151

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.46731391
2MP0010094_abnormal_chromosome_stability4.45688784
3MP0003111_abnormal_nucleus_morphology4.38463684
4MP0004957_abnormal_blastocyst_morpholog4.23944255
5MP0008057_abnormal_DNA_replication4.06520241
6MP0003077_abnormal_cell_cycle3.91413995
7MP0008058_abnormal_DNA_repair3.46513725
8MP0008007_abnormal_cellular_replicative2.87064807
9MP0008932_abnormal_embryonic_tissue2.75184019
10MP0002396_abnormal_hematopoietic_system2.45585085
11MP0000372_irregular_coat_pigmentation2.22370438
12MP0002163_abnormal_gland_morphology2.17370957
13MP0001529_abnormal_vocalization2.13072970
14MP0003786_premature_aging2.07128489
15MP0008877_abnormal_DNA_methylation2.04643673
16MP0000350_abnormal_cell_proliferation2.00149406
17MP0001730_embryonic_growth_arrest1.97510320
18MP0003123_paternal_imprinting1.96065058
19MP0000490_abnormal_crypts_of1.89273551
20MP0010030_abnormal_orbit_morphology1.83227331
21MP0006292_abnormal_olfactory_placode1.79055545
22MP0002234_abnormal_pharynx_morphology1.76890385
23MP0005499_abnormal_olfactory_system1.70010730
24MP0005394_taste/olfaction_phenotype1.70010730
25MP0006035_abnormal_mitochondrial_morpho1.66937029
26MP0003718_maternal_effect1.64003800
27MP0001545_abnormal_hematopoietic_system1.61338625
28MP0005397_hematopoietic_system_phenotyp1.61338625
29MP0010352_gastrointestinal_tract_polyps1.56207872
30MP0001697_abnormal_embryo_size1.55110228
31MP0000313_abnormal_cell_death1.53921640
32MP0001672_abnormal_embryogenesis/_devel1.51682478
33MP0005380_embryogenesis_phenotype1.51682478
34MP0002837_dystrophic_cardiac_calcinosis1.49765111
35MP0004808_abnormal_hematopoietic_stem1.48713524
36MP0009333_abnormal_splenocyte_physiolog1.47841243
37MP0003122_maternal_imprinting1.47553411
38MP0002132_abnormal_respiratory_system1.47169040
39MP0002019_abnormal_tumor_incidence1.46005954
40MP0006072_abnormal_retinal_apoptosis1.43811984
41MP0002080_prenatal_lethality1.40447901
42MP0002210_abnormal_sex_determination1.39253811
43MP0009379_abnormal_foot_pigmentation1.39068464
44MP0002085_abnormal_embryonic_tissue1.34893956
45MP0010307_abnormal_tumor_latency1.34351895
46MP0003984_embryonic_growth_retardation1.33676730
47MP0005084_abnormal_gallbladder_morpholo1.32717193
48MP0003186_abnormal_redox_activity1.30688931
49MP0001293_anophthalmia1.29577624
50MP0002088_abnormal_embryonic_growth/wei1.29330795
51MP0009697_abnormal_copulation1.29117972
52MP0003763_abnormal_thymus_physiology1.27228273
53MP0003567_abnormal_fetal_cardiomyocyte1.25724380
54MP0001145_abnormal_male_reproductive1.23339989
55MP0005379_endocrine/exocrine_gland_phen1.22794913
56MP0001929_abnormal_gametogenesis1.22514435
57MP0003315_abnormal_perineum_morphology1.18176507
58MP0002086_abnormal_extraembryonic_tissu1.16944861
59MP0003806_abnormal_nucleotide_metabolis1.14583810
60MP0001764_abnormal_homeostasis1.13469141
61MP0002160_abnormal_reproductive_system1.13333524
62MP0002084_abnormal_developmental_patter1.13113505
63MP0005408_hypopigmentation1.12507667
64MP0002736_abnormal_nociception_after1.12294435
65MP0000703_abnormal_thymus_morphology1.12127064
66MP0004197_abnormal_fetal_growth/weight/1.11445665
67MP0002398_abnormal_bone_marrow1.11129536
68MP0001905_abnormal_dopamine_level1.10952954
69MP0001346_abnormal_lacrimal_gland1.07752713
70MP0002722_abnormal_immune_system1.06941409
71MP0000653_abnormal_sex_gland1.04735914
72MP0000689_abnormal_spleen_morphology1.02442654
73MP0004142_abnormal_muscle_tone1.00521782
74MP0000631_abnormal_neuroendocrine_gland0.99692302
75MP0000858_altered_metastatic_potential0.97935907
76MP0003890_abnormal_embryonic-extraembry0.96249419
77MP0004133_heterotaxia0.96071589
78MP0005075_abnormal_melanosome_morpholog0.94497903
79MP0005174_abnormal_tail_pigmentation0.94366128
80MP0005645_abnormal_hypothalamus_physiol0.93715867
81MP0002233_abnormal_nose_morphology0.91400098
82MP0001853_heart_inflammation0.90959716
83MP0002429_abnormal_blood_cell0.89101535
84MP0001119_abnormal_female_reproductive0.88349487
85MP0005646_abnormal_pituitary_gland0.88128578
86MP0005389_reproductive_system_phenotype0.87539857
87MP0003646_muscle_fatigue0.87479157
88MP0003121_genomic_imprinting0.87465208
89MP0003941_abnormal_skin_development0.86634358
90MP0009278_abnormal_bone_marrow0.84659635
91MP0002277_abnormal_respiratory_mucosa0.84583918
92MP0006276_abnormal_autonomic_nervous0.83129027
93MP0002822_catalepsy0.81889835
94MP0002938_white_spotting0.81329724
95MP0000358_abnormal_cell_content/0.80574312
96MP0000566_synostosis0.79843966
97MP0003119_abnormal_digestive_system0.79644078
98MP0002653_abnormal_ependyma_morphology0.79010714
99MP0000049_abnormal_middle_ear0.77825296
100MP0003787_abnormal_imprinting0.77705396
101MP0002102_abnormal_ear_morphology0.76302464
102MP0006054_spinal_hemorrhage0.74958372
103MP0000716_abnormal_immune_system0.74838416
104MP0002697_abnormal_eye_size0.74493314
105MP0005551_abnormal_eye_electrophysiolog0.74146020
106MP0002095_abnormal_skin_pigmentation0.74105185
107MP0000678_abnormal_parathyroid_gland0.72793872
108MP0003938_abnormal_ear_development0.72773962
109MP0003698_abnormal_male_reproductive0.72740725
110MP0005253_abnormal_eye_physiology0.72643117
111MP0002405_respiratory_system_inflammati0.71865655
112MP0006036_abnormal_mitochondrial_physio0.71101828
113MP0002111_abnormal_tail_morphology0.70866875
114MP0005410_abnormal_fertilization0.70799325
115MP0002638_abnormal_pupillary_reflex0.69917001
116MP0008789_abnormal_olfactory_epithelium0.69436072
117MP0004147_increased_porphyrin_level0.69343934
118MP0003880_abnormal_central_pattern0.69277640
119MP0003942_abnormal_urinary_system0.67028101
120MP0009053_abnormal_anal_canal0.66544043
121MP0003011_delayed_dark_adaptation0.66410704
122MP0008872_abnormal_physiological_respon0.66305593
123MP0005391_vision/eye_phenotype0.66278173
124MP0005195_abnormal_posterior_eye0.65326614
125MP0001919_abnormal_reproductive_system0.63415915
126MP0001324_abnormal_eye_pigmentation0.62743106
127MP0008995_early_reproductive_senescence0.62435831
128MP0005384_cellular_phenotype0.61680762
129MP0001286_abnormal_eye_development0.60160746
130MP0003937_abnormal_limbs/digits/tail_de0.60153736
131MP0009672_abnormal_birth_weight0.60064990
132MP0005076_abnormal_cell_differentiation0.59712287
133MP0003136_yellow_coat_color0.59312631
134MP0000685_abnormal_immune_system0.58229445
135MP0003656_abnormal_erythrocyte_physiolo0.57981637
136MP0001800_abnormal_humoral_immune0.57823458
137MP0002420_abnormal_adaptive_immunity0.57383560
138MP0000477_abnormal_intestine_morphology0.56941128
139MP0001819_abnormal_immune_cell0.56476144
140MP0002161_abnormal_fertility/fecundity0.55192193
141MP0005671_abnormal_response_to0.55086984

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.55770250
2Abnormal mitochondria in muscle tissue (HP:0008316)5.29585447
3Reticulocytopenia (HP:0001896)5.26939755
4Acute encephalopathy (HP:0006846)5.02332301
5Mitochondrial inheritance (HP:0001427)5.01047160
6Abnormality of cells of the erythroid lineage (HP:0012130)5.00559145
7Abnormal number of erythroid precursors (HP:0012131)4.91581135
8Birth length less than 3rd percentile (HP:0003561)4.77899380
9Increased CSF lactate (HP:0002490)4.58755116
10Progressive macrocephaly (HP:0004481)4.51981856
11Hepatocellular necrosis (HP:0001404)4.46969691
12Lipid accumulation in hepatocytes (HP:0006561)4.09931326
13Chromsome breakage (HP:0040012)4.09547860
14Chromosomal breakage induced by crosslinking agents (HP:0003221)4.07626557
15Hepatic necrosis (HP:0002605)4.06884521
16Renal Fanconi syndrome (HP:0001994)3.84720332
17Breast hypoplasia (HP:0003187)3.81450924
18Cerebral edema (HP:0002181)3.73557418
19Oral leukoplakia (HP:0002745)3.66848025
20Aplastic anemia (HP:0001915)3.65564530
21Increased intramyocellular lipid droplets (HP:0012240)3.50236324
22Meckel diverticulum (HP:0002245)3.39463148
23Pallor (HP:0000980)3.37600280
24Abnormality of the ileum (HP:0001549)3.32001941
25Abnormality of the preputium (HP:0100587)3.28238313
26Macrocytic anemia (HP:0001972)3.27029447
27Absent thumb (HP:0009777)3.19597963
28Lactic acidosis (HP:0003128)3.12298348
29Patellar aplasia (HP:0006443)3.10479386
30Aplasia/Hypoplasia of the sacrum (HP:0008517)3.10224445
31Selective tooth agenesis (HP:0001592)3.05948131
32Abnormality of chromosome stability (HP:0003220)3.03864673
33Aplasia/Hypoplasia of the uvula (HP:0010293)3.01750224
34Colon cancer (HP:0003003)2.99539976
35Abnormality of the anterior horn cell (HP:0006802)2.97593785
36Degeneration of anterior horn cells (HP:0002398)2.97593785
37Aplasia/Hypoplasia of the patella (HP:0006498)2.96404001
38Increased muscle lipid content (HP:0009058)2.94926898
39Carpal bone hypoplasia (HP:0001498)2.90749885
40Rough bone trabeculation (HP:0100670)2.90260122
41Respiratory failure (HP:0002878)2.85023736
42Exercise intolerance (HP:0003546)2.80658043
43Hyperglycinemia (HP:0002154)2.80571131
44Absent radius (HP:0003974)2.74157269
45Microretrognathia (HP:0000308)2.73280381
4611 pairs of ribs (HP:0000878)2.70393936
47Duplicated collecting system (HP:0000081)2.68711749
48Myelodysplasia (HP:0002863)2.66726100
49Respiratory difficulties (HP:0002880)2.66478942
50Premature graying of hair (HP:0002216)2.62173733
51Duodenal stenosis (HP:0100867)2.61900102
52Small intestinal stenosis (HP:0012848)2.61900102
53Optic disc pallor (HP:0000543)2.60700180
54Type I transferrin isoform profile (HP:0003642)2.57460970
55Leukodystrophy (HP:0002415)2.55679073
56Bone marrow hypocellularity (HP:0005528)2.55352743
57Increased serum pyruvate (HP:0003542)2.55027943
58Medulloblastoma (HP:0002885)2.54611956
59Absent forearm bone (HP:0003953)2.53358448
60Aplasia involving forearm bones (HP:0009822)2.53358448
61Triphalangeal thumb (HP:0001199)2.51836800
62Trismus (HP:0000211)2.47044230
63Impulsivity (HP:0100710)2.39032549
64Abnormality of the renal collecting system (HP:0004742)2.38077440
65Cerebral hypomyelination (HP:0006808)2.36904801
66Decreased activity of mitochondrial respiratory chain (HP:0008972)2.35350935
67Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.35350935
68Lethargy (HP:0001254)2.32546344
69Horseshoe kidney (HP:0000085)2.32074116
70Abnormal lung lobation (HP:0002101)2.30092311
71Pancytopenia (HP:0001876)2.29978447
72Abnormal number of incisors (HP:0011064)2.28407225
73Ectopic kidney (HP:0000086)2.27878324
74Tracheoesophageal fistula (HP:0002575)2.26192770
75Abnormality of glycolysis (HP:0004366)2.25293848
76Supernumerary spleens (HP:0009799)2.24523962
77Abnormality of the heme biosynthetic pathway (HP:0010472)2.23704207
78Cleft eyelid (HP:0000625)2.21291305
79Abnormality of renal resorption (HP:0011038)2.21076483
80Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.19207047
81Methylmalonic aciduria (HP:0012120)2.17950136
82Neoplasm of the pancreas (HP:0002894)2.17733832
83Sloping forehead (HP:0000340)2.16851739
84Abnormality of the duodenum (HP:0002246)2.16398708
85Thrombocytosis (HP:0001894)2.15319031
86Hypoplasia of the radius (HP:0002984)2.13490350
87Methylmalonic acidemia (HP:0002912)2.09812423
88Atresia of the external auditory canal (HP:0000413)2.09660566
89Abnormal trabecular bone morphology (HP:0100671)2.09515296
90Agnosia (HP:0010524)2.08839014
91Abdominal situs inversus (HP:0003363)2.08680910
92Abnormality of abdominal situs (HP:0011620)2.08680910
93Clubbing of toes (HP:0100760)2.07966399
94Cellular immunodeficiency (HP:0005374)2.07775281
95Abnormality of reticulocytes (HP:0004312)2.07026616
96Sclerocornea (HP:0000647)2.06703065
97Short thumb (HP:0009778)2.02838581
98Exertional dyspnea (HP:0002875)2.02099147
99Premature ovarian failure (HP:0008209)2.00600699
100CNS demyelination (HP:0007305)1.99382196
101Abnormality of urine glucose concentration (HP:0011016)1.98734310
102Glycosuria (HP:0003076)1.98734310
103Rhabdomyosarcoma (HP:0002859)1.98709036
104Increased serum lactate (HP:0002151)1.98214082
105Emotional lability (HP:0000712)1.94459035
106Abnormality of the labia minora (HP:0012880)1.94068846
107Abnormality of the carotid arteries (HP:0005344)1.93312556
108Stenosis of the external auditory canal (HP:0000402)1.91969969
109Septo-optic dysplasia (HP:0100842)1.91589703
110Reduced antithrombin III activity (HP:0001976)1.90162621
111Sparse eyelashes (HP:0000653)1.89931843
112Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.89557828
113Secondary amenorrhea (HP:0000869)1.89490336
114Ependymoma (HP:0002888)1.89120346
115Squamous cell carcinoma (HP:0002860)1.88629080
116Multiple enchondromatosis (HP:0005701)1.87131759
117Abnormality of pyrimidine metabolism (HP:0004353)1.86366710
118Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.86209339
119Lymphoma (HP:0002665)1.85941298
120Muscle fiber atrophy (HP:0100295)1.85516761
121Abnormality of DNA repair (HP:0003254)1.85233784
122Abnormal spermatogenesis (HP:0008669)1.84610069
1233-Methylglutaconic aciduria (HP:0003535)1.83850442
124Microvesicular hepatic steatosis (HP:0001414)1.81815237
125Pancreatic fibrosis (HP:0100732)1.80805097
126Acute lymphatic leukemia (HP:0006721)1.80621043
127Medial flaring of the eyebrow (HP:0010747)1.80239417
128Increased hepatocellular lipid droplets (HP:0006565)1.79050961
129Nephroblastoma (Wilms tumor) (HP:0002667)1.78838917
130Asplenia (HP:0001746)1.77733619
131Aplasia/hypoplasia of the uterus (HP:0008684)1.76810659
132Pancreatic cysts (HP:0001737)1.76656253
133X-linked dominant inheritance (HP:0001423)1.76368278
134IgM deficiency (HP:0002850)1.76101001
135Dicarboxylic aciduria (HP:0003215)1.74965596
136Abnormality of dicarboxylic acid metabolism (HP:0010995)1.74965596
137Hypoplastic pelvis (HP:0008839)1.72644960
138Abnormality of serum amino acid levels (HP:0003112)1.71993951
139Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.71938442
140Slender long bone (HP:0003100)1.70417716
141Poor head control (HP:0002421)1.69429311
142Abnormal protein glycosylation (HP:0012346)1.68926210
143Abnormal glycosylation (HP:0012345)1.68926210
144Abnormal protein N-linked glycosylation (HP:0012347)1.68926210
145Hyperphosphaturia (HP:0003109)1.68798820
146Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.68669936
147Abnormality of alanine metabolism (HP:0010916)1.68669936
148Hyperalaninemia (HP:0003348)1.68669936
149True hermaphroditism (HP:0010459)1.65636319
150Abnormality of midbrain morphology (HP:0002418)1.65333722
151Molar tooth sign on MRI (HP:0002419)1.65333722
152Depressed nasal ridge (HP:0000457)1.64843021
153Hypoplasia of the uterus (HP:0000013)1.60164861
154Abnormality of methionine metabolism (HP:0010901)1.59610619
155Generalized aminoaciduria (HP:0002909)1.59498373
156Adrenal hypoplasia (HP:0000835)1.55844994
157Progressive microcephaly (HP:0000253)1.54914096
158Abnormality of glycine metabolism (HP:0010895)1.54828162
159Abnormality of serine family amino acid metabolism (HP:0010894)1.54828162

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK25.92650683
2BUB15.01897070
3WEE14.31187971
4CDC73.66420022
5EIF2AK12.97177260
6NME22.75761664
7STK162.69225958
8NEK22.62629293
9SRPK12.57935542
10TAF12.55948144
11PLK42.44751092
12TLK12.29384892
13VRK12.26861254
14NUAK12.25823836
15TTK2.17231462
16TESK22.09186110
17ACVR1B2.04556963
18PLK11.96854333
19DYRK31.95591927
20BRSK21.93464490
21EIF2AK31.92997154
22CDK71.92118394
23MKNK11.73803165
24RPS6KA41.66943966
25AURKB1.59896821
26ATR1.57315689
27PIM21.53272707
28MAP4K21.42898874
29CCNB11.40181770
30CHEK21.38786893
31AURKA1.37649372
32MKNK21.37584059
33TRIM281.35104172
34MAP3K101.32937359
35RPS6KB21.32408228
36KDR1.30606687
37NEK11.29500745
38PASK1.29081061
39TSSK61.27653641
40ZAK1.24967329
41CDK191.24959986
42CDK41.18263302
43MAP3K81.17943928
44TESK11.17385879
45MST41.15636844
46STK41.12470447
47CSNK1G31.12119423
48BRSK11.12003526
49MAP3K111.11362083
50PLK31.08664233
51SMG11.07833483
52EIF2AK21.06178466
53STK101.06141011
54CDK121.05576369
55CHEK11.02683106
56WNK31.02444428
57PDK21.00321930
58PAK40.99801316
59SCYL20.99732247
60PIM10.95302028
61DAPK10.93177472
62LIMK10.91890754
63CDK80.90823360
64EPHA20.87730345
65CSNK1G10.86108304
66MAP4K10.84101175
67MAP2K70.83542905
68PBK0.82859215
69CSNK1G20.81124600
70GRK10.79907939
71BMPR1B0.78064933
72CSNK2A10.76118425
73ATM0.75741696
74IRAK30.75283328
75MAPKAPK50.74843146
76TGFBR10.72293634
77CDK20.71673525
78CSNK1A1L0.70771463
79EPHB20.70147345
80WNK40.69907038
81PAK10.69406773
82CSNK2A20.69170406
83TAOK20.68322807
84BRAF0.67863678
85DAPK30.65618604
86BRD40.64590178
87MAP3K120.64481321
88IRAK40.62236410
89RPS6KA50.55854012
90MAP2K30.55723372
91BLK0.54395169
92INSRR0.53655551
93FLT30.52751282
94YES10.52097187
95MAPKAPK30.51832041
96DYRK20.49858812
97CDK10.49725164
98BTK0.48537305
99NME10.47834718
100LRRK20.47286642
101EEF2K0.47185544
102ARAF0.47099446
103ADRBK20.46555779
104TEC0.45697557
105CLK10.44739196
106BCKDK0.42322837
107MAP3K40.39956757
108PRKCI0.39786384
109TXK0.39734748
110CDK60.39008589
111IKBKB0.37058889
112CDK11A0.36437458
113CDK140.36098359
114STK38L0.35509070
115AKT20.35371381
116CSNK1E0.34502256
117ABL20.34416707
118ILK0.33973953
119STK30.33820542
120TIE10.33061883
121MELK0.31669352
122ZAP700.30870352
123CDK150.28967175
124CSNK1A10.28800450
125CDK180.28604129
126PLK20.26639885
127PRKCG0.25123324
128LYN0.24078629
129TYK20.22648074
130NLK0.21519296
131MAPKAPK20.20686524
132JAK30.20081329
133MAP3K30.19284824
134KIT0.18696388
135NEK90.18453480
136PRKDC0.17359653

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.11494224
2Ribosome_Homo sapiens_hsa030104.28526711
3Mismatch repair_Homo sapiens_hsa034304.25587402
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.43707365
5RNA polymerase_Homo sapiens_hsa030203.31856828
6Proteasome_Homo sapiens_hsa030503.31535935
7Base excision repair_Homo sapiens_hsa034103.28080597
8* Spliceosome_Homo sapiens_hsa030403.27563775
9Homologous recombination_Homo sapiens_hsa034403.20882103
10RNA transport_Homo sapiens_hsa030132.81886525
11Nucleotide excision repair_Homo sapiens_hsa034202.81785648
12Pyrimidine metabolism_Homo sapiens_hsa002402.73565338
13Cell cycle_Homo sapiens_hsa041102.52329363
14Fanconi anemia pathway_Homo sapiens_hsa034602.43558319
15One carbon pool by folate_Homo sapiens_hsa006702.30569771
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.97773637
17Basal transcription factors_Homo sapiens_hsa030221.95642174
18Non-homologous end-joining_Homo sapiens_hsa034501.87989322
19* RNA degradation_Homo sapiens_hsa030181.81462405
20p53 signaling pathway_Homo sapiens_hsa041151.56092626
21mRNA surveillance pathway_Homo sapiens_hsa030151.49142646
22Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.45381417
23Cardiac muscle contraction_Homo sapiens_hsa042601.43985722
24Purine metabolism_Homo sapiens_hsa002301.43258846
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.40950869
26Fatty acid elongation_Homo sapiens_hsa000621.40481753
27Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.36269786
28Epstein-Barr virus infection_Homo sapiens_hsa051691.09539209
29Folate biosynthesis_Homo sapiens_hsa007901.09099019
30Protein export_Homo sapiens_hsa030601.08311528
31Propanoate metabolism_Homo sapiens_hsa006401.07911905
32Systemic lupus erythematosus_Homo sapiens_hsa053221.01413405
33Pyruvate metabolism_Homo sapiens_hsa006201.00280927
34Sulfur relay system_Homo sapiens_hsa041220.99704862
35Herpes simplex infection_Homo sapiens_hsa051680.98758767
36Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.98031560
372-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.96455952
38Huntingtons disease_Homo sapiens_hsa050160.93453718
39Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.88992431
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.88509038
41Sulfur metabolism_Homo sapiens_hsa009200.83501905
42Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.83275078
43Parkinsons disease_Homo sapiens_hsa050120.82948500
44Pentose phosphate pathway_Homo sapiens_hsa000300.81569271
45Steroid biosynthesis_Homo sapiens_hsa001000.81235862
46Cysteine and methionine metabolism_Homo sapiens_hsa002700.79870683
47Antigen processing and presentation_Homo sapiens_hsa046120.76247161
48Peroxisome_Homo sapiens_hsa041460.75981477
49Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.75267126
50Viral carcinogenesis_Homo sapiens_hsa052030.72944001
51Oocyte meiosis_Homo sapiens_hsa041140.71776663
52Drug metabolism - other enzymes_Homo sapiens_hsa009830.69669962
53Vitamin B6 metabolism_Homo sapiens_hsa007500.69103418
54Glutathione metabolism_Homo sapiens_hsa004800.67599203
55Oxidative phosphorylation_Homo sapiens_hsa001900.66301602
56Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.66290747
57Selenocompound metabolism_Homo sapiens_hsa004500.66220095
58HTLV-I infection_Homo sapiens_hsa051660.65897157
59Primary immunodeficiency_Homo sapiens_hsa053400.61523731
60Cyanoamino acid metabolism_Homo sapiens_hsa004600.58534780
61Biosynthesis of amino acids_Homo sapiens_hsa012300.56382950
62Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.54636374
63Butanoate metabolism_Homo sapiens_hsa006500.54497628
64Legionellosis_Homo sapiens_hsa051340.53434048
65Thyroid cancer_Homo sapiens_hsa052160.50877670
66Phototransduction_Homo sapiens_hsa047440.48041380
67Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.47464983
68Transcriptional misregulation in cancer_Homo sapiens_hsa052020.46876415
69Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.46052919
70N-Glycan biosynthesis_Homo sapiens_hsa005100.44932489
71Fatty acid metabolism_Homo sapiens_hsa012120.43660366
72Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.43472801
73Measles_Homo sapiens_hsa051620.41403932
74Basal cell carcinoma_Homo sapiens_hsa052170.41060718
75Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.40611456
76Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.40430358
77Small cell lung cancer_Homo sapiens_hsa052220.39786277
78Apoptosis_Homo sapiens_hsa042100.38474842
79Maturity onset diabetes of the young_Homo sapiens_hsa049500.37968898
80Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.37009644
81MicroRNAs in cancer_Homo sapiens_hsa052060.35241796
82Arachidonic acid metabolism_Homo sapiens_hsa005900.35009384
83Collecting duct acid secretion_Homo sapiens_hsa049660.34481966
84NF-kappa B signaling pathway_Homo sapiens_hsa040640.33711699
85Metabolic pathways_Homo sapiens_hsa011000.32596918
86Shigellosis_Homo sapiens_hsa051310.30050516
87Pentose and glucuronate interconversions_Homo sapiens_hsa000400.29853089
88Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.29446306
89Notch signaling pathway_Homo sapiens_hsa043300.28567726
90Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.28541993
91Hematopoietic cell lineage_Homo sapiens_hsa046400.28506786
92Fructose and mannose metabolism_Homo sapiens_hsa000510.28079221
93Hepatitis B_Homo sapiens_hsa051610.27944676
94TGF-beta signaling pathway_Homo sapiens_hsa043500.27083685
95RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.27075102
96Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.27014151
97Intestinal immune network for IgA production_Homo sapiens_hsa046720.26309390
98Renin-angiotensin system_Homo sapiens_hsa046140.25972941
99Galactose metabolism_Homo sapiens_hsa000520.24454021
100Tyrosine metabolism_Homo sapiens_hsa003500.23633766
101Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.22993182
102Hippo signaling pathway_Homo sapiens_hsa043900.22669910
103Asthma_Homo sapiens_hsa053100.22227930
104Alcoholism_Homo sapiens_hsa050340.22120267
105Alzheimers disease_Homo sapiens_hsa050100.22111597
106Bladder cancer_Homo sapiens_hsa052190.22067574
107Carbon metabolism_Homo sapiens_hsa012000.21977152
108Regulation of autophagy_Homo sapiens_hsa041400.21295291
109Influenza A_Homo sapiens_hsa051640.20047887
110Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.19774662
111Hedgehog signaling pathway_Homo sapiens_hsa043400.19118630
112SNARE interactions in vesicular transport_Homo sapiens_hsa041300.18904042
113Fatty acid degradation_Homo sapiens_hsa000710.18899714
114Linoleic acid metabolism_Homo sapiens_hsa005910.18293011
115Acute myeloid leukemia_Homo sapiens_hsa052210.17353211
116Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.17075544
117Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.16484343
118Colorectal cancer_Homo sapiens_hsa052100.16084958
119Allograft rejection_Homo sapiens_hsa053300.15420829
120Pathways in cancer_Homo sapiens_hsa052000.14810799
121Arginine and proline metabolism_Homo sapiens_hsa003300.14386046
122Primary bile acid biosynthesis_Homo sapiens_hsa001200.13479268
123Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.13248249
124Fat digestion and absorption_Homo sapiens_hsa049750.13172236
125Nitrogen metabolism_Homo sapiens_hsa009100.12994732
126NOD-like receptor signaling pathway_Homo sapiens_hsa046210.12645988
127beta-Alanine metabolism_Homo sapiens_hsa004100.11942124
128Tryptophan metabolism_Homo sapiens_hsa003800.11409629
129Leishmaniasis_Homo sapiens_hsa051400.09244544
130Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.08006168
131Vitamin digestion and absorption_Homo sapiens_hsa049770.07426378
132Vibrio cholerae infection_Homo sapiens_hsa051100.07415108
133HIF-1 signaling pathway_Homo sapiens_hsa040660.07399075
134Chemical carcinogenesis_Homo sapiens_hsa052040.06825690
135Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.06055156
136Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.06035336

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