LSM3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)5.82975964
2chaperone-mediated protein transport (GO:0072321)5.65723954
3mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.37468553
4establishment of protein localization to mitochondrial membrane (GO:0090151)5.32311952
5respiratory electron transport chain (GO:0022904)5.18727310
6ribosomal small subunit biogenesis (GO:0042274)5.11905083
7viral transcription (GO:0019083)5.07186809
8electron transport chain (GO:0022900)5.06786941
9maturation of SSU-rRNA (GO:0030490)5.04367575
10translational termination (GO:0006415)4.96123539
11telomere maintenance via semi-conservative replication (GO:0032201)4.87147577
12DNA strand elongation involved in DNA replication (GO:0006271)4.81569174
13DNA deamination (GO:0045006)4.61504577
14DNA strand elongation (GO:0022616)4.60405561
15protein complex biogenesis (GO:0070271)4.44524233
16telomere maintenance via recombination (GO:0000722)4.40085513
17mitochondrial respiratory chain complex assembly (GO:0033108)4.38478939
18regulation of mitochondrial translation (GO:0070129)4.38212471
19SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.37386559
20ribosomal large subunit biogenesis (GO:0042273)4.36466070
21translational elongation (GO:0006414)4.35383942
22CENP-A containing nucleosome assembly (GO:0034080)4.35240636
23protein neddylation (GO:0045116)4.32541654
24cotranslational protein targeting to membrane (GO:0006613)4.31883228
25protein targeting to ER (GO:0045047)4.27106181
26chromatin remodeling at centromere (GO:0031055)4.23355418
27DNA replication initiation (GO:0006270)4.23321556
28proteasome assembly (GO:0043248)4.15774805
29mitotic recombination (GO:0006312)4.15375404
30establishment of integrated proviral latency (GO:0075713)4.13687746
31mitochondrial respiratory chain complex I assembly (GO:0032981)4.10856487
32NADH dehydrogenase complex assembly (GO:0010257)4.10856487
33mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.10856487
34translational initiation (GO:0006413)4.06328582
35establishment of protein localization to endoplasmic reticulum (GO:0072599)4.05179770
36protein localization to endoplasmic reticulum (GO:0070972)4.03491629
37nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.98438127
38cellular protein complex disassembly (GO:0043624)3.92415609
39viral life cycle (GO:0019058)3.90462634
40telomere maintenance via telomere lengthening (GO:0010833)3.89480009
41ribonucleoprotein complex biogenesis (GO:0022613)3.87418033
42DNA replication checkpoint (GO:0000076)3.85121182
43formation of translation preinitiation complex (GO:0001731)3.78054176
44nucleotide-excision repair, DNA gap filling (GO:0006297)3.77919559
45DNA unwinding involved in DNA replication (GO:0006268)3.77741537
46kinetochore organization (GO:0051383)3.76507343
47DNA replication-independent nucleosome assembly (GO:0006336)3.76320032
48DNA replication-independent nucleosome organization (GO:0034724)3.76320032
49deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.75759391
50protein targeting to mitochondrion (GO:0006626)3.75266922
51respiratory chain complex IV assembly (GO:0008535)3.71502818
52negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.69702456
53termination of RNA polymerase III transcription (GO:0006386)3.63748941
54transcription elongation from RNA polymerase III promoter (GO:0006385)3.63748941
55spliceosomal snRNP assembly (GO:0000387)3.63583878
56translation (GO:0006412)3.62094792
57kinetochore assembly (GO:0051382)3.57762189
58cytochrome complex assembly (GO:0017004)3.57333002
59rRNA processing (GO:0006364)3.56651262
60pseudouridine synthesis (GO:0001522)3.54483316
61mitotic metaphase plate congression (GO:0007080)3.52926268
62transcription-coupled nucleotide-excision repair (GO:0006283)3.52413975
63establishment of protein localization to mitochondrion (GO:0072655)3.50837575
64nucleobase biosynthetic process (GO:0046112)3.50297777
65rRNA modification (GO:0000154)3.49318097
66protein localization to mitochondrion (GO:0070585)3.49262625
67anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.49198765
68regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.48239197
69protein complex disassembly (GO:0043241)3.47015974
70positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.44520698
71ATP biosynthetic process (GO:0006754)3.44445261
72rRNA metabolic process (GO:0016072)3.43918978
73spliceosomal complex assembly (GO:0000245)3.40587206
74histone exchange (GO:0043486)3.40416835
75negative regulation of ligase activity (GO:0051352)3.40050192
76negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.40050192
77oxidative phosphorylation (GO:0006119)3.39970029
78mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.36022717
79* exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.35647293
80establishment of viral latency (GO:0019043)3.34949197
81purine nucleoside triphosphate biosynthetic process (GO:0009145)3.32559025
82positive regulation of ligase activity (GO:0051351)3.32332730
83macromolecular complex disassembly (GO:0032984)3.32204419
84DNA damage response, detection of DNA damage (GO:0042769)3.29678246
85* nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.28806104
86purine nucleobase biosynthetic process (GO:0009113)3.28627182
87hydrogen ion transmembrane transport (GO:1902600)3.28314665
88purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.28250123
89cellular component biogenesis (GO:0044085)3.25071474
907-methylguanosine mRNA capping (GO:0006370)3.23825709
91regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.23580545
92regulation of mitotic spindle checkpoint (GO:1903504)3.23580545
93ribosome biogenesis (GO:0042254)3.23455165
94DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.23103432
95DNA replication-dependent nucleosome organization (GO:0034723)3.22839024
96DNA replication-dependent nucleosome assembly (GO:0006335)3.22839024
97protein localization to kinetochore (GO:0034501)3.22454961
98* nuclear-transcribed mRNA catabolic process (GO:0000956)3.22206962
99RNA capping (GO:0036260)3.21193800
1007-methylguanosine RNA capping (GO:0009452)3.21193800
101DNA double-strand break processing (GO:0000729)3.19729967
102signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.18529551
103intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.18529551
104regulation of ubiquitin-protein transferase activity (GO:0051438)3.17843584
105inner mitochondrial membrane organization (GO:0007007)3.17245094
106signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.17099887
107signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.17099887
108signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.17099887
109ribosome assembly (GO:0042255)3.16949439
110water-soluble vitamin biosynthetic process (GO:0042364)3.14372665
111metaphase plate congression (GO:0051310)3.13457335
112attachment of spindle microtubules to kinetochore (GO:0008608)3.11983927
113ATP synthesis coupled proton transport (GO:0015986)3.11768008
114energy coupled proton transport, down electrochemical gradient (GO:0015985)3.11768008
115viral mRNA export from host cell nucleus (GO:0046784)3.11467113
116signal transduction involved in DNA damage checkpoint (GO:0072422)3.10958269
117signal transduction involved in DNA integrity checkpoint (GO:0072401)3.10958269
118RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.08103607
119tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.08103607
120signal transduction involved in cell cycle checkpoint (GO:0072395)3.07180892
121G1/S transition of mitotic cell cycle (GO:0000082)3.05971488
122cell cycle G1/S phase transition (GO:0044843)3.05971488
123* mRNA catabolic process (GO:0006402)3.05651258
124regulation of cellular amino acid metabolic process (GO:0006521)3.01068104
125cullin deneddylation (GO:0010388)3.00536794
126DNA ligation (GO:0006266)3.00032898
127antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.99863896
128transcription elongation from RNA polymerase I promoter (GO:0006362)2.99203161
129regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.99112316
130positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.96614466
131telomere organization (GO:0032200)2.95109350
132deoxyribonucleotide biosynthetic process (GO:0009263)2.94878256

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.59757654
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.49691180
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.19617576
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.73351605
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.67998545
6* E2F4_17652178_ChIP-ChIP_JURKAT_Human3.63162818
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.56148975
8* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.38537048
9SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.34306407
10ETS1_20019798_ChIP-Seq_JURKAT_Human3.18146001
11FOXM1_23109430_ChIP-Seq_U2OS_Human3.15197984
12* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.07025180
13MYC_18358816_ChIP-ChIP_MESCs_Mouse3.02714360
14MYC_19079543_ChIP-ChIP_MESCs_Mouse3.00865164
15* HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.99468177
16* CREB1_15753290_ChIP-ChIP_HEK293T_Human2.97613118
17* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.94763794
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.82935999
19NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.82408794
20ELF1_17652178_ChIP-ChIP_JURKAT_Human2.59056091
21VDR_23849224_ChIP-Seq_CD4+_Human2.56497423
22HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.51721854
23XRN2_22483619_ChIP-Seq_HELA_Human2.46591299
24CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.34269798
25E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.33565564
26NELFA_20434984_ChIP-Seq_ESCs_Mouse2.32785125
27FOXP3_21729870_ChIP-Seq_TREG_Human2.22077424
28E2F1_18555785_ChIP-Seq_MESCs_Mouse2.21613223
29DCP1A_22483619_ChIP-Seq_HELA_Human2.19209974
30THAP11_20581084_ChIP-Seq_MESCs_Mouse2.11087669
31MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.08129395
32TTF2_22483619_ChIP-Seq_HELA_Human2.06551870
33ELK1_19687146_ChIP-ChIP_HELA_Human2.05938182
34MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.05915163
35FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.96724368
36SRF_21415370_ChIP-Seq_HL-1_Mouse1.91782090
37GABP_19822575_ChIP-Seq_HepG2_Human1.91234049
38SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.90970175
39FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.89270990
40YY1_21170310_ChIP-Seq_MESCs_Mouse1.87686240
41* MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.84042255
42AR_21909140_ChIP-Seq_LNCAP_Human1.78096864
43HOXB4_20404135_ChIP-ChIP_EML_Mouse1.77167694
44E2F1_21310950_ChIP-Seq_MCF-7_Human1.75330583
45ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.74234703
46TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.71957381
47* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.71896723
48HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.70296190
49* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.69864998
50POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.69319645
51PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.67550749
52NANOG_18555785_ChIP-Seq_MESCs_Mouse1.65365443
53CIITA_25753668_ChIP-Seq_RAJI_Human1.50745795
54FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.49251550
55ERG_20887958_ChIP-Seq_HPC-7_Mouse1.48669373
56PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.46741013
57POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.41485913
58* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.38593996
59EWS_26573619_Chip-Seq_HEK293_Human1.35401194
60HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.35395586
61SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.29003361
62MYC_18940864_ChIP-ChIP_HL60_Human1.28905832
63CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.27865490
64SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.24858333
65PADI4_21655091_ChIP-ChIP_MCF-7_Human1.23578736
66ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.22062221
67KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.21606725
68FUS_26573619_Chip-Seq_HEK293_Human1.21006336
69NOTCH1_21737748_ChIP-Seq_TLL_Human1.18678418
70KDM5A_27292631_Chip-Seq_BREAST_Human1.18649622
71ELK1_22589737_ChIP-Seq_MCF10A_Human1.17818530
72* NANOG_16153702_ChIP-ChIP_HESCs_Human1.16014624
73CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.15014283
74SOX2_18555785_ChIP-Seq_MESCs_Mouse1.14873412
75VDR_22108803_ChIP-Seq_LS180_Human1.14822786
76* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.14262918
77KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.13676792
78POU5F1_16153702_ChIP-ChIP_HESCs_Human1.09639456
79RBPJ_22232070_ChIP-Seq_NCS_Mouse1.08530324
80* SOX2_16153702_ChIP-ChIP_HESCs_Human1.05166032
81BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.04110677
82E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.03590173
83TP63_19390658_ChIP-ChIP_HaCaT_Human1.02279772
84GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.00978545
85CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.99863611
86IRF1_19129219_ChIP-ChIP_H3396_Human0.99542436
87SPI1_23547873_ChIP-Seq_NB4_Human0.99033670
88ZNF274_21170338_ChIP-Seq_K562_Hela0.96629849
89ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.96579695
90CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.95406700
91IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.94019515
92CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.93528290
93STAT3_1855785_ChIP-Seq_MESCs_Mouse0.89361496
94TFEB_21752829_ChIP-Seq_HELA_Human0.84293882
95SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.83231182
96POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.83109501
97SALL1_21062744_ChIP-ChIP_HESCs_Human0.82461331
98* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.81609907
99ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.81248676
100TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.78726658
101DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.77642546
102* SOX17_20123909_ChIP-Seq_XEN_Mouse0.76560056
103* ELF5_23300383_ChIP-Seq_T47D_Human0.75285992
104DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.74991638
105* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.74188122
106FLI1_27457419_Chip-Seq_LIVER_Mouse0.73870011
107TP53_22573176_ChIP-Seq_HFKS_Human0.72549218
108NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.72442020
109HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.72411453
110MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.69587057
111CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.69076892
112HTT_18923047_ChIP-ChIP_STHdh_Human0.67530188
113SOX2_18692474_ChIP-Seq_MEFs_Mouse0.65962051
114SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.65718748
115POU3F2_20337985_ChIP-ChIP_501MEL_Human0.65013012
116KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.64867412
117OCT4_18692474_ChIP-Seq_MEFs_Mouse0.64820002
118MYC_22102868_ChIP-Seq_BL_Human0.64487639
119RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.64425202
120CTCF_18555785_ChIP-Seq_MESCs_Mouse0.63563067
121GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.63274449
122EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.63119897
123SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.63035699

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.39734664
2MP0010094_abnormal_chromosome_stability4.61226004
3MP0008057_abnormal_DNA_replication4.48770990
4MP0004957_abnormal_blastocyst_morpholog4.34679906
5MP0003111_abnormal_nucleus_morphology3.98900497
6MP0003077_abnormal_cell_cycle3.91419336
7MP0008058_abnormal_DNA_repair3.66281252
8MP0008007_abnormal_cellular_replicative2.87844456
9MP0008932_abnormal_embryonic_tissue2.84841686
10MP0009379_abnormal_foot_pigmentation2.54211179
11MP0002396_abnormal_hematopoietic_system2.45258395
12MP0003941_abnormal_skin_development2.38684340
13MP0003786_premature_aging2.34328658
14MP0008877_abnormal_DNA_methylation2.18239388
15MP0006072_abnormal_retinal_apoptosis2.04503096
16MP0006292_abnormal_olfactory_placode1.93240885
17MP0003123_paternal_imprinting1.85124278
18MP0003718_maternal_effect1.81300155
19MP0000350_abnormal_cell_proliferation1.81252917
20MP0000490_abnormal_crypts_of1.78792402
21MP0001730_embryonic_growth_arrest1.71047620
22MP0003315_abnormal_perineum_morphology1.65734536
23MP0003136_yellow_coat_color1.60562642
24MP0002837_dystrophic_cardiac_calcinosis1.56598328
25MP0003011_delayed_dark_adaptation1.56317770
26MP0002736_abnormal_nociception_after1.52344990
27MP0002132_abnormal_respiratory_system1.48932653
28MP0000313_abnormal_cell_death1.42735829
29MP0003186_abnormal_redox_activity1.39611096
30MP0009333_abnormal_splenocyte_physiolog1.35211273
31MP0002210_abnormal_sex_determination1.35090341
32MP0008789_abnormal_olfactory_epithelium1.33435160
33MP0002938_white_spotting1.32666229
34MP0005084_abnormal_gallbladder_morpholo1.32227932
35MP0003567_abnormal_fetal_cardiomyocyte1.30200869
36MP0005075_abnormal_melanosome_morpholog1.28370579
37MP0002019_abnormal_tumor_incidence1.28028633
38MP0004133_heterotaxia1.27238313
39MP0004808_abnormal_hematopoietic_stem1.25369168
40MP0003763_abnormal_thymus_physiology1.24800260
41MP0003806_abnormal_nucleotide_metabolis1.24126333
42MP0001697_abnormal_embryo_size1.23659944
43MP0006036_abnormal_mitochondrial_physio1.23419007
44MP0002102_abnormal_ear_morphology1.23170331
45MP0002080_prenatal_lethality1.16767004
46MP0002095_abnormal_skin_pigmentation1.15790579
47MP0001764_abnormal_homeostasis1.13801805
48MP0001529_abnormal_vocalization1.13786110
49MP0002398_abnormal_bone_marrow1.12432921
50MP0001145_abnormal_male_reproductive1.12116945
51MP0005174_abnormal_tail_pigmentation1.11868923
52MP0003121_genomic_imprinting1.11756764
53MP0001293_anophthalmia1.11233508
54MP0001672_abnormal_embryogenesis/_devel1.11175765
55MP0005380_embryogenesis_phenotype1.11175765
56MP0002160_abnormal_reproductive_system1.10401326
57MP0002085_abnormal_embryonic_tissue1.09549236
58MP0001835_abnormal_antigen_presentation1.07648705
59MP0005253_abnormal_eye_physiology1.06933996
60MP0000703_abnormal_thymus_morphology1.06716811
61MP0001853_heart_inflammation1.05566922
62MP0001929_abnormal_gametogenesis1.04433929
63MP0000631_abnormal_neuroendocrine_gland1.04193568
64MP0003195_calcinosis1.02317391
65MP0002722_abnormal_immune_system1.01443274
66MP0005379_endocrine/exocrine_gland_phen1.00342253
67MP0001188_hyperpigmentation1.00130506
68MP0008872_abnormal_physiological_respon0.99332855
69MP0000689_abnormal_spleen_morphology0.99317015
70MP0000372_irregular_coat_pigmentation0.99117222
71MP0000653_abnormal_sex_gland0.97918768
72MP0005389_reproductive_system_phenotype0.97781411
73MP0009697_abnormal_copulation0.97696991
74MP0006035_abnormal_mitochondrial_morpho0.94424906
75MP0005671_abnormal_response_to0.93542233
76MP0002429_abnormal_blood_cell0.92562552
77MP0001986_abnormal_taste_sensitivity0.91671799
78MP0003984_embryonic_growth_retardation0.91331299
79MP0002163_abnormal_gland_morphology0.90712213
80MP0001984_abnormal_olfaction0.90707967
81MP0004147_increased_porphyrin_level0.90178156
82MP0002090_abnormal_vision0.88449435
83MP0003890_abnormal_embryonic-extraembry0.88290451
84MP0002088_abnormal_embryonic_growth/wei0.87982803
85MP0004142_abnormal_muscle_tone0.87892716
86MP0009785_altered_susceptibility_to0.87509708
87MP0001286_abnormal_eye_development0.86537701
88MP0001968_abnormal_touch/_nociception0.86460690
89MP0008995_early_reproductive_senescence0.85504049
90MP0000566_synostosis0.85095637
91MP0008875_abnormal_xenobiotic_pharmacok0.84398336
92MP0000716_abnormal_immune_system0.83852051
93MP0001905_abnormal_dopamine_level0.83843689
94MP0001727_abnormal_embryo_implantation0.82397865
95MP0002084_abnormal_developmental_patter0.81999221
96MP0001119_abnormal_female_reproductive0.81174487
97MP0005332_abnormal_amino_acid0.80571429
98MP0010030_abnormal_orbit_morphology0.80526781
99MP0002148_abnormal_hypersensitivity_rea0.79998347
100MP0005551_abnormal_eye_electrophysiolog0.79764295
101MP0005397_hematopoietic_system_phenotyp0.78572151
102MP0001545_abnormal_hematopoietic_system0.78572151
103MP0004215_abnormal_myocardial_fiber0.77372904
104MP0010307_abnormal_tumor_latency0.77296784
105MP0002420_abnormal_adaptive_immunity0.75775443
106MP0002234_abnormal_pharynx_morphology0.75728430
107MP0002277_abnormal_respiratory_mucosa0.74411936
108MP0001819_abnormal_immune_cell0.74101368
109MP0002233_abnormal_nose_morphology0.74085516
110MP0000358_abnormal_cell_content/0.73769290
111MP0009046_muscle_twitch0.72551349
112MP0002086_abnormal_extraembryonic_tissu0.72110333
113MP0004197_abnormal_fetal_growth/weight/0.71757970
114MP0003938_abnormal_ear_development0.71569028
115MP0003698_abnormal_male_reproductive0.70030261
116MP0005395_other_phenotype0.69913198
117MP0005408_hypopigmentation0.69618026
118MP0003937_abnormal_limbs/digits/tail_de0.68810942
119MP0000858_altered_metastatic_potential0.68806125
120MP0005391_vision/eye_phenotype0.68478590
121MP0001881_abnormal_mammary_gland0.68262225
122MP0001800_abnormal_humoral_immune0.68117433
123MP0006054_spinal_hemorrhage0.67994716
124MP0000015_abnormal_ear_pigmentation0.67956128
125MP0002653_abnormal_ependyma_morphology0.67543402
126MP0004145_abnormal_muscle_electrophysio0.67354032
127MP0002638_abnormal_pupillary_reflex0.67047483
128MP0002452_abnormal_antigen_presenting0.66937642
129MP0000647_abnormal_sebaceous_gland0.66720829
130MP0002751_abnormal_autonomic_nervous0.66684062
131MP0002697_abnormal_eye_size0.66588210
132MP0005636_abnormal_mineral_homeostasis0.66407554
133MP0005394_taste/olfaction_phenotype0.66314417
134MP0000049_abnormal_middle_ear0.65965887
135MP0001919_abnormal_reproductive_system0.65326521
136MP0001485_abnormal_pinna_reflex0.63639562
137MP0005409_darkened_coat_color0.63286442
138MP0002723_abnormal_immune_serum0.62638734

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)5.46800898
2Reticulocytopenia (HP:0001896)5.36483652
3Abnormal number of erythroid precursors (HP:0012131)5.17970209
4Birth length less than 3rd percentile (HP:0003561)4.48800268
5Cerebral edema (HP:0002181)3.88962734
6Aplastic anemia (HP:0001915)3.80392482
7Chromsome breakage (HP:0040012)3.63569229
8Macrocytic anemia (HP:0001972)3.58388596
9Breast hypoplasia (HP:0003187)3.54322145
10Chromosomal breakage induced by crosslinking agents (HP:0003221)3.51677684
11Oral leukoplakia (HP:0002745)3.47698894
12Acute necrotizing encephalopathy (HP:0006965)3.46177315
13Pallor (HP:0000980)3.46028295
14Increased hepatocellular lipid droplets (HP:0006565)3.44113674
15Mitochondrial inheritance (HP:0001427)3.35789502
16Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.26395583
17Decreased activity of mitochondrial respiratory chain (HP:0008972)3.26395583
183-Methylglutaconic aciduria (HP:0003535)3.15524319
19Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.13808237
20Abnormal mitochondria in muscle tissue (HP:0008316)3.10735243
21Increased CSF lactate (HP:0002490)3.06341005
22Hepatocellular necrosis (HP:0001404)3.05981638
23Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.03029585
24Colon cancer (HP:0003003)2.96613600
25Rough bone trabeculation (HP:0100670)2.95205098
26Methylmalonic acidemia (HP:0002912)2.93506269
27Abnormality of the preputium (HP:0100587)2.90004973
28Leukodystrophy (HP:0002415)2.89948900
29Lipid accumulation in hepatocytes (HP:0006561)2.89867499
30Congenital, generalized hypertrichosis (HP:0004540)2.88681368
31Increased muscle lipid content (HP:0009058)2.85604879
32Meckel diverticulum (HP:0002245)2.79174269
33Duplicated collecting system (HP:0000081)2.78381639
34Carpal bone hypoplasia (HP:0001498)2.76645208
35Aplasia/Hypoplasia of the sacrum (HP:0008517)2.75925645
36Increased serum lactate (HP:0002151)2.74944476
37Exertional dyspnea (HP:0002875)2.73322125
38Abnormality of chromosome stability (HP:0003220)2.71153789
3911 pairs of ribs (HP:0000878)2.69776562
40Patellar aplasia (HP:0006443)2.67796354
41Progressive macrocephaly (HP:0004481)2.67276511
42Methylmalonic aciduria (HP:0012120)2.67078531
43Abnormality of methionine metabolism (HP:0010901)2.66212139
44Abnormality of the ileum (HP:0001549)2.65924696
45Abnormality of renal resorption (HP:0011038)2.64519987
46Premature graying of hair (HP:0002216)2.64404664
47Acute encephalopathy (HP:0006846)2.61832917
48Abnormality of the renal collecting system (HP:0004742)2.61369988
49Cerebral hypomyelination (HP:0006808)2.59390575
50Renal Fanconi syndrome (HP:0001994)2.55623159
51Absent thumb (HP:0009777)2.55301511
52Hepatic necrosis (HP:0002605)2.54564132
53Optic disc pallor (HP:0000543)2.52647417
54Aplasia/Hypoplasia of the patella (HP:0006498)2.52490142
55Type I transferrin isoform profile (HP:0003642)2.46650840
56Bone marrow hypocellularity (HP:0005528)2.42714124
57Lethargy (HP:0001254)2.42177059
58Abnormal lung lobation (HP:0002101)2.40882032
59Microretrognathia (HP:0000308)2.40036768
60Microvesicular hepatic steatosis (HP:0001414)2.39738826
61Aplasia/Hypoplasia of the uvula (HP:0010293)2.38249594
62Selective tooth agenesis (HP:0001592)2.36266072
63Myelodysplasia (HP:0002863)2.35303872
64Pancytopenia (HP:0001876)2.35207753
65Exercise intolerance (HP:0003546)2.31789269
66Increased intramyocellular lipid droplets (HP:0012240)2.29942758
67Abnormality of the labia minora (HP:0012880)2.27483603
68Abnormal trabecular bone morphology (HP:0100671)2.25772487
69Duodenal stenosis (HP:0100867)2.25070045
70Small intestinal stenosis (HP:0012848)2.25070045
71Abnormality of aspartate family amino acid metabolism (HP:0010899)2.23614401
72Muscle fiber atrophy (HP:0100295)2.22827888
73Septo-optic dysplasia (HP:0100842)2.22514317
74Type 2 muscle fiber atrophy (HP:0003554)2.21959085
75Megaloblastic anemia (HP:0001889)2.20903084
76Supernumerary spleens (HP:0009799)2.19557371
77Absent radius (HP:0003974)2.19444233
78Triphalangeal thumb (HP:0001199)2.19175158
79Abnormality of serum amino acid levels (HP:0003112)2.17795190
80Respiratory difficulties (HP:0002880)2.15673874
81IgM deficiency (HP:0002850)2.14154115
82Asplenia (HP:0001746)2.13484693
83Cellular immunodeficiency (HP:0005374)2.12837944
84Medulloblastoma (HP:0002885)2.12207531
85Abnormality of urine glucose concentration (HP:0011016)2.11185605
86Glycosuria (HP:0003076)2.11185605
87Thrombocytosis (HP:0001894)2.10373665
88Cleft eyelid (HP:0000625)2.09776481
89Abnormality of the anterior horn cell (HP:0006802)2.09547921
90Degeneration of anterior horn cells (HP:0002398)2.09547921
91Abnormal number of incisors (HP:0011064)2.07230208
92Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.05198952
93Abnormal protein N-linked glycosylation (HP:0012347)2.05198952
94Abnormal protein glycosylation (HP:0012346)2.05198952
95Abnormal glycosylation (HP:0012345)2.05198952
96Horseshoe kidney (HP:0000085)2.04299678
97CNS demyelination (HP:0007305)2.04035298
98Aplasia involving forearm bones (HP:0009822)2.03764900
99Absent forearm bone (HP:0003953)2.03764900
100Hyperphosphaturia (HP:0003109)2.02451247
101Sloping forehead (HP:0000340)2.01591017
102Pancreatic fibrosis (HP:0100732)2.00991812
103Abnormality of alanine metabolism (HP:0010916)2.00094619
104Hyperalaninemia (HP:0003348)2.00094619
105Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.00094619
106Reduced antithrombin III activity (HP:0001976)1.99786253
107Abnormality of the heme biosynthetic pathway (HP:0010472)1.97930497
108Lactic acidosis (HP:0003128)1.97528710
109Amniotic constriction ring (HP:0009775)1.97439561
110Abnormality of placental membranes (HP:0011409)1.97439561
111Stenosis of the external auditory canal (HP:0000402)1.95548970
112Irregular epiphyses (HP:0010582)1.95110260
113Hyperglycinemia (HP:0002154)1.94748897
114X-linked dominant inheritance (HP:0001423)1.94161708
115Abnormality of glycolysis (HP:0004366)1.93811240
116Increased serum pyruvate (HP:0003542)1.93811240
117Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.92401532
118Pancreatic cysts (HP:0001737)1.91537872
119Sparse eyelashes (HP:0000653)1.90505475
120Aplasia/Hypoplasia of the spleen (HP:0010451)1.89987220
121Agnosia (HP:0010524)1.89765584
122Respiratory failure (HP:0002878)1.89380417
123Lymphoma (HP:0002665)1.89060411
124Tracheoesophageal fistula (HP:0002575)1.89054130
125Hypoplasia of the radius (HP:0002984)1.88485959
126Trismus (HP:0000211)1.86972246
127Poor head control (HP:0002421)1.85674647
128Hypoplasia of the pons (HP:0012110)1.85638727
129Neoplasm of the pancreas (HP:0002894)1.83050602
130Abnormality of the duodenum (HP:0002246)1.82204108
131Abnormality of the pons (HP:0007361)1.81719428
132Homocystinuria (HP:0002156)1.81017907
133Abnormality of homocysteine metabolism (HP:0010919)1.81017907
134Glossoptosis (HP:0000162)1.79610677
135Generalized aminoaciduria (HP:0002909)1.78881989
136Hypoplasia of the capital femoral epiphysis (HP:0003090)1.77016034
137Secondary amenorrhea (HP:0000869)1.76407755
138Absent septum pellucidum (HP:0001331)1.74891200
139Multiple enchondromatosis (HP:0005701)1.71763671
140Abnormality of midbrain morphology (HP:0002418)1.71582486
141Molar tooth sign on MRI (HP:0002419)1.71582486
142True hermaphroditism (HP:0010459)1.68984009
143Pendular nystagmus (HP:0012043)1.68615638

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.79510048
2BUB14.70882043
3WEE14.41718578
4STK163.42566333
5CDC73.32402661
6EIF2AK13.22325745
7SRPK13.16345462
8VRK13.01386864
9NME22.59245727
10PLK42.49853482
11BRSK22.31686266
12MKNK12.14174493
13EIF2AK32.13846652
14TAF11.98816595
15TLK11.97472203
16CCNB11.97077120
17NUAK11.92744154
18TTK1.79060194
19PLK11.74230536
20NEK21.67252637
21TSSK61.67235435
22PBK1.59481004
23ACVR1B1.59303672
24AURKB1.49431041
25MKNK21.48603944
26DYRK31.48027509
27CDK71.45126800
28ATR1.44246558
29MST41.43592318
30PIM21.42099892
31PASK1.42032643
32WNK31.41080000
33RPS6KB21.37090730
34PLK31.36363140
35NME11.34903797
36TESK21.33504203
37BRSK11.32967837
38ZAK1.29918279
39CDK81.22498326
40MAP4K21.21162086
41CHEK21.17095365
42AURKA1.15760368
43TRIM281.15228998
44STK41.10560027
45NEK11.08137424
46EIF2AK21.03802418
47CDK191.03223239
48TEC1.00709842
49PDK20.97926184
50CSNK1G10.95338533
51RPS6KA40.94805687
52TNIK0.91517749
53IRAK40.90931787
54PAK40.85261249
55MUSK0.84894994
56CHEK10.84420771
57RPS6KA50.84063373
58FLT30.82784316
59KDR0.82643483
60DYRK20.82414439
61CSNK2A10.81720200
62TGFBR10.77140494
63CSNK2A20.76504395
64MAP3K80.76276621
65CSNK1G20.76244006
66OXSR10.75726312
67GRK10.74562237
68EPHA20.74461422
69PLK20.73284232
70KIT0.71538590
71PIM10.68336502
72YES10.67394199
73CDK40.67038937
74BRAF0.65916435
75PNCK0.63722878
76CSNK1A1L0.63449245
77IRAK30.63447906
78FRK0.61943300
79ATM0.61718249
80CLK10.60387190
81BTK0.58482110
82PAK10.55812837
83SCYL20.54606528
84CDK20.54307678
85MAP2K70.51735533
86CSNK1E0.50687305
87ADRBK20.50407975
88TXK0.50018132
89INSRR0.48973284
90STK100.48707832
91MAP3K120.48484614
92STK38L0.46133384
93CDK10.45981782
94DAPK10.45752233
95ILK0.45308052
96LIMK10.45145198
97LRRK20.44683917
98MYLK0.44358510
99BRD40.44320339
100MELK0.43920856
101PRKCI0.42576946
102MAP4K10.42544627
103STK30.42265282
104ERBB30.42050683
105PRKCG0.41913058
106BCR0.41469487
107CSF1R0.40704187
108ABL20.39203242
109DAPK30.39165393
110MAP3K40.39123753
111IKBKB0.38473970
112CDK30.38366807
113TESK10.38021215
114ARAF0.35450712
115ALK0.35306918
116BMPR1B0.35283635
117LYN0.34871856
118CSNK1G30.33273825
119MAP3K110.32003411
120CSNK1A10.30417494
121PINK10.28809930
122BLK0.28254204
123WNK40.27863954
124STK390.27794820
125MAPKAPK50.27779046
126NEK60.26856213
127ERBB40.26833711
128OBSCN0.25806533
129GRK70.24396356
130PRKDC0.23604501
131PRKACB0.23437190
132AKT20.23142772
133NLK0.22991635
134BCKDK0.22587164
135TAOK20.22269548

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.81908581
2DNA replication_Homo sapiens_hsa030304.73764477
3Mismatch repair_Homo sapiens_hsa034304.13544393
4Proteasome_Homo sapiens_hsa030504.05374747
5RNA polymerase_Homo sapiens_hsa030203.71407434
6Homologous recombination_Homo sapiens_hsa034403.22289027
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.16437134
8* Spliceosome_Homo sapiens_hsa030403.16141404
9Nucleotide excision repair_Homo sapiens_hsa034202.85956604
10Base excision repair_Homo sapiens_hsa034102.75735821
11Pyrimidine metabolism_Homo sapiens_hsa002402.72803199
12RNA transport_Homo sapiens_hsa030132.45463231
13Fanconi anemia pathway_Homo sapiens_hsa034602.26627267
14Non-homologous end-joining_Homo sapiens_hsa034502.20606245
15Cell cycle_Homo sapiens_hsa041102.12672674
16Basal transcription factors_Homo sapiens_hsa030222.04268575
17Oxidative phosphorylation_Homo sapiens_hsa001902.02360623
18Parkinsons disease_Homo sapiens_hsa050121.99846840
19One carbon pool by folate_Homo sapiens_hsa006701.87720726
20Protein export_Homo sapiens_hsa030601.84698064
21* RNA degradation_Homo sapiens_hsa030181.79890295
22Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.73649335
23Huntingtons disease_Homo sapiens_hsa050161.69161559
24Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.66761462
25Purine metabolism_Homo sapiens_hsa002301.50003164
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.30497340
27Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.26791665
28Propanoate metabolism_Homo sapiens_hsa006401.20321399
29Alzheimers disease_Homo sapiens_hsa050101.18988328
30Pyruvate metabolism_Homo sapiens_hsa006201.18920396
31mRNA surveillance pathway_Homo sapiens_hsa030151.18081058
32Systemic lupus erythematosus_Homo sapiens_hsa053221.17517705
33p53 signaling pathway_Homo sapiens_hsa041151.14099177
34Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.10741044
35Epstein-Barr virus infection_Homo sapiens_hsa051691.06379352
36Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.06304415
37Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.94680365
38Herpes simplex infection_Homo sapiens_hsa051680.81658396
39Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.81062410
40Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.73994772
41Sulfur metabolism_Homo sapiens_hsa009200.72912199
42Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.72557809
43Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.69696537
44Folate biosynthesis_Homo sapiens_hsa007900.69653603
45Primary immunodeficiency_Homo sapiens_hsa053400.68108621
46Pentose and glucuronate interconversions_Homo sapiens_hsa000400.67147337
47Collecting duct acid secretion_Homo sapiens_hsa049660.66232228
48Butanoate metabolism_Homo sapiens_hsa006500.64339123
49Glutathione metabolism_Homo sapiens_hsa004800.63529391
50Antigen processing and presentation_Homo sapiens_hsa046120.62579220
51Peroxisome_Homo sapiens_hsa041460.60351134
52Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.59859994
53Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.59115324
54Oocyte meiosis_Homo sapiens_hsa041140.58187488
552-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.56052074
56Maturity onset diabetes of the young_Homo sapiens_hsa049500.55781588
57Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.55494261
58Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.55356596
59Viral carcinogenesis_Homo sapiens_hsa052030.54913607
60Allograft rejection_Homo sapiens_hsa053300.54179955
61Chemical carcinogenesis_Homo sapiens_hsa052040.51269161
62Cysteine and methionine metabolism_Homo sapiens_hsa002700.50926411
63Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.49096871
64Pentose phosphate pathway_Homo sapiens_hsa000300.48966025
65Vitamin digestion and absorption_Homo sapiens_hsa049770.47850952
66Tryptophan metabolism_Homo sapiens_hsa003800.46541476
67Alcoholism_Homo sapiens_hsa050340.46484347
68Legionellosis_Homo sapiens_hsa051340.44003658
69Phototransduction_Homo sapiens_hsa047440.43717796
70Sulfur relay system_Homo sapiens_hsa041220.43643942
71Drug metabolism - other enzymes_Homo sapiens_hsa009830.43273841
72Arachidonic acid metabolism_Homo sapiens_hsa005900.42963676
73Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.42752014
74Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.42685380
75Cardiac muscle contraction_Homo sapiens_hsa042600.42601696
76HTLV-I infection_Homo sapiens_hsa051660.41575037
77Metabolic pathways_Homo sapiens_hsa011000.41501209
78N-Glycan biosynthesis_Homo sapiens_hsa005100.37867733
79Cyanoamino acid metabolism_Homo sapiens_hsa004600.36504541
80Fatty acid degradation_Homo sapiens_hsa000710.36448722
81Retinol metabolism_Homo sapiens_hsa008300.35622066
82Hematopoietic cell lineage_Homo sapiens_hsa046400.35344632
83Intestinal immune network for IgA production_Homo sapiens_hsa046720.35238061
84Transcriptional misregulation in cancer_Homo sapiens_hsa052020.34481084
85RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.33885967
86Asthma_Homo sapiens_hsa053100.33034346
87SNARE interactions in vesicular transport_Homo sapiens_hsa041300.32902285
88Autoimmune thyroid disease_Homo sapiens_hsa053200.31564436
89NF-kappa B signaling pathway_Homo sapiens_hsa040640.31346307
90Measles_Homo sapiens_hsa051620.31225815
91beta-Alanine metabolism_Homo sapiens_hsa004100.30835748
92NOD-like receptor signaling pathway_Homo sapiens_hsa046210.30633055
93Caffeine metabolism_Homo sapiens_hsa002320.30558060
94Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.29396665
95Fatty acid metabolism_Homo sapiens_hsa012120.27933035
96Tyrosine metabolism_Homo sapiens_hsa003500.27231091
97Shigellosis_Homo sapiens_hsa051310.26099427
98Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.26003736
99Graft-versus-host disease_Homo sapiens_hsa053320.25116493
100Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.24989892
101Nitrogen metabolism_Homo sapiens_hsa009100.22281711
102Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.21932932
103Steroid hormone biosynthesis_Homo sapiens_hsa001400.21342742
104Apoptosis_Homo sapiens_hsa042100.21288819
105Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.21097202
106Biosynthesis of amino acids_Homo sapiens_hsa012300.20425802
107Primary bile acid biosynthesis_Homo sapiens_hsa001200.19469479
108Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.17518322
109Type I diabetes mellitus_Homo sapiens_hsa049400.15907002
110Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.15374884
111Linoleic acid metabolism_Homo sapiens_hsa005910.15334111
112Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.14205341
113Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.13998352
114Fructose and mannose metabolism_Homo sapiens_hsa000510.13981002
115Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.13960789
116Selenocompound metabolism_Homo sapiens_hsa004500.13643035
117Small cell lung cancer_Homo sapiens_hsa052220.13339012
118Hepatitis B_Homo sapiens_hsa051610.12812523
119TGF-beta signaling pathway_Homo sapiens_hsa043500.12367714
120Fatty acid elongation_Homo sapiens_hsa000620.12180962
121Influenza A_Homo sapiens_hsa051640.12035207
122Thyroid cancer_Homo sapiens_hsa052160.10905427
123Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.10680303
124Vibrio cholerae infection_Homo sapiens_hsa051100.09167392
125Mineral absorption_Homo sapiens_hsa049780.08106413
126Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.07919574
127Fat digestion and absorption_Homo sapiens_hsa049750.07787573
128Olfactory transduction_Homo sapiens_hsa047400.07402880
129Pathways in cancer_Homo sapiens_hsa052000.07320637
130MicroRNAs in cancer_Homo sapiens_hsa052060.07038363
131Vitamin B6 metabolism_Homo sapiens_hsa007500.06860816
132Ether lipid metabolism_Homo sapiens_hsa005650.06802859
133Carbon metabolism_Homo sapiens_hsa012000.06164749
134Regulation of autophagy_Homo sapiens_hsa041400.06017413
135Colorectal cancer_Homo sapiens_hsa052100.04797117
136Basal cell carcinoma_Homo sapiens_hsa052170.04071804
137Arginine and proline metabolism_Homo sapiens_hsa003300.03347506
138Steroid biosynthesis_Homo sapiens_hsa001000.03271160

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