LSM3P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)9.62574937
2negative regulation of calcium ion-dependent exocytosis (GO:0045955)9.46396609
3regulation of translational termination (GO:0006449)9.42673828
4adult feeding behavior (GO:0008343)9.23524966
5regulation of acrosome reaction (GO:0060046)7.75075967
6regulation of protein glycosylation (GO:0060049)7.60610953
7positive regulation of cAMP-mediated signaling (GO:0043950)7.23080552
8negative regulation of nitric oxide biosynthetic process (GO:0045019)6.68738656
9sphingosine metabolic process (GO:0006670)6.59412651
10piRNA metabolic process (GO:0034587)6.43793367
11notochord development (GO:0030903)6.08959111
12regulation of female receptivity (GO:0045924)6.07674171
13diol metabolic process (GO:0034311)5.96441614
14DNA replication-dependent nucleosome organization (GO:0034723)5.88793101
15DNA replication-dependent nucleosome assembly (GO:0006335)5.88793101
16thrombin receptor signaling pathway (GO:0070493)5.77303378
17sphingoid metabolic process (GO:0046519)5.65970119
18glycerol ether metabolic process (GO:0006662)5.64558146
19female mating behavior (GO:0060180)5.28971952
20regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)5.26643372
21ether metabolic process (GO:0018904)5.20900977
22negative regulation of glycoprotein biosynthetic process (GO:0010561)5.18973735
23regulation of glutamate receptor signaling pathway (GO:1900449)5.14869799
24cellular response to ammonium ion (GO:0071242)4.87243097
25ncRNA catabolic process (GO:0034661)4.69942773
26pyrimidine dimer repair (GO:0006290)4.68779284
27regulation of cAMP-mediated signaling (GO:0043949)4.67614056
28mRNA cleavage (GO:0006379)4.64365172
29regulation of ER to Golgi vesicle-mediated transport (GO:0060628)4.58913540
30glomerular visceral epithelial cell development (GO:0072015)4.44602929
31cellular response to alkaloid (GO:0071312)4.07489927
32negative regulation of adenylate cyclase activity (GO:0007194)4.05826274
33negative regulation of cell-matrix adhesion (GO:0001953)4.03690053
34signal complex assembly (GO:0007172)4.01758493
35coenzyme catabolic process (GO:0009109)3.93333193
36glomerular epithelial cell development (GO:0072310)3.91499733
37negative regulation of cyclase activity (GO:0031280)3.85639324
38N-terminal protein amino acid acetylation (GO:0006474)3.81137936
39negative regulation of lyase activity (GO:0051350)3.79196759
40vitamin catabolic process (GO:0009111)3.75678280
41fat-soluble vitamin catabolic process (GO:0042363)3.75678280
42negative regulation of glycoprotein metabolic process (GO:1903019)3.73412308
43omega-hydroxylase P450 pathway (GO:0097267)3.62943287
44cornea development in camera-type eye (GO:0061303)3.56853659
45detection of chemical stimulus involved in sensory perception of smell (GO:0050911)3.55720376
46transmission of nerve impulse (GO:0019226)3.54555804
47glycerophospholipid catabolic process (GO:0046475)3.49501650
48regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.37343821
49regulation of translational elongation (GO:0006448)3.35391537
50cell-cell junction maintenance (GO:0045217)3.27708754
51glycosphingolipid metabolic process (GO:0006687)3.26836852
52negative regulation of exocytosis (GO:0045920)3.25608480
53neuronal action potential (GO:0019228)3.22621661
54thyroid hormone generation (GO:0006590)3.22487314
55dopamine receptor signaling pathway (GO:0007212)3.17015054
56positive regulation of cardiac muscle cell differentiation (GO:2000727)3.13800415
57regulation of memory T cell differentiation (GO:0043380)3.10489276
58response to morphine (GO:0043278)3.03707647
59chemical homeostasis within a tissue (GO:0048875)3.03679520
60spermatid development (GO:0007286)3.02055563
61membrane depolarization during action potential (GO:0086010)3.01477700
62negative regulation of cAMP biosynthetic process (GO:0030818)2.98930154
63RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.98838291
64dopamine transport (GO:0015872)2.97892504
65positive regulation of fatty acid transport (GO:2000193)2.95271059
66left/right axis specification (GO:0070986)2.92840598
67thyroid hormone metabolic process (GO:0042403)2.91221014
68response to isoquinoline alkaloid (GO:0014072)2.90406996
69positive regulation of icosanoid secretion (GO:0032305)2.88693544
70negative regulation of cyclic nucleotide biosynthetic process (GO:0030803)2.87130446
71positive regulation of nitric oxide biosynthetic process (GO:0045429)2.87045114
72detection of light stimulus involved in visual perception (GO:0050908)2.84920933
73detection of light stimulus involved in sensory perception (GO:0050962)2.84920933
74regulation of rhodopsin mediated signaling pathway (GO:0022400)2.84297729
75lung secretory cell differentiation (GO:0061140)2.82335940
76regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.81492122
77indolalkylamine metabolic process (GO:0006586)2.80966700
78regulation of odontogenesis (GO:0042481)2.79071287
79wound healing, spreading of epidermal cells (GO:0035313)2.75042760
80multicellular organismal reproductive behavior (GO:0033057)2.75016485
81glomerular basement membrane development (GO:0032836)2.74186778
82regulation of calcium ion-dependent exocytosis (GO:0017158)2.72564649
83response to caffeine (GO:0031000)2.71557052
84sensory perception of pain (GO:0019233)2.69490290
85negative regulation of nucleotide biosynthetic process (GO:0030809)2.67545089
86negative regulation of purine nucleotide biosynthetic process (GO:1900372)2.67545089
87smooth muscle tissue development (GO:0048745)2.65073159
88steroid catabolic process (GO:0006706)2.65006743
89glycolipid metabolic process (GO:0006664)2.62149565
90negative regulation of cAMP metabolic process (GO:0030815)2.61675354
91adenylate cyclase-activating G-protein coupled receptor signaling pathway (GO:0007189)2.60529734
92detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.57412722
93positive regulation of cholesterol efflux (GO:0010875)2.57259611
94rhodopsin mediated signaling pathway (GO:0016056)2.56308701
95membrane lipid metabolic process (GO:0006643)2.54412051
96negative regulation of cytosolic calcium ion concentration (GO:0051481)14.9085511
97negative regulation of cAMP-mediated signaling (GO:0043951)12.7216895
98opioid receptor signaling pathway (GO:0038003)11.9190455
99behavioral response to ethanol (GO:0048149)10.1623344
100ether lipid metabolic process (GO:0046485)10.0276520

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse5.74051801
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.68175801
3RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.06851160
4PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse3.67109480
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.31191928
6POU5F1_26923725_Chip-Seq_MESODERM_Mouse3.25128228
7TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.25128228
8VDR_22108803_ChIP-Seq_LS180_Human3.22229386
9RXR_22108803_ChIP-Seq_LS180_Human2.57568243
10MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.55298286
11ZNF274_21170338_ChIP-Seq_K562_Hela2.25354193
12GBX2_23144817_ChIP-Seq_PC3_Human2.19365406
13TAF15_26573619_Chip-Seq_HEK293_Human2.19070509
14SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.99023531
15FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.95531456
16NANOG_19829295_ChIP-Seq_ESCs_Human1.90511288
17SOX2_19829295_ChIP-Seq_ESCs_Human1.90511288
18ZFP57_27257070_Chip-Seq_ESCs_Mouse1.81742718
19TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.72242053
20EGR1_19032775_ChIP-ChIP_M12_Human1.71519496
21IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.71137955
22CBP_20019798_ChIP-Seq_JUKART_Human1.71137955
23VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.65679815
24HTT_18923047_ChIP-ChIP_STHdh_Human1.65300422
25BCAT_22108803_ChIP-Seq_LS180_Human1.64898939
26PCGF2_27294783_Chip-Seq_ESCs_Mouse1.63042772
27DROSHA_22980978_ChIP-Seq_HELA_Human1.62384803
28EGR1_23403033_ChIP-Seq_LIVER_Mouse1.62378228
29CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.62363772
30TCF4_23295773_ChIP-Seq_U87_Human1.62164084
31ESR1_20079471_ChIP-ChIP_T-47D_Human1.55621050
32STAT3_23295773_ChIP-Seq_U87_Human1.53655959
33SUZ12_27294783_Chip-Seq_NPCs_Mouse1.53008563
34PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.45365833
35CTBP2_25329375_ChIP-Seq_LNCAP_Human1.45336034
36IRF1_19129219_ChIP-ChIP_H3396_Human1.45030333
37P300_19829295_ChIP-Seq_ESCs_Human1.42813679
38NFE2_27457419_Chip-Seq_LIVER_Mouse1.39474211
39PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.38209650
40PCGF2_27294783_Chip-Seq_NPCs_Mouse1.34480069
41FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.34457709
42SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.34333294
43SMAD3_21741376_ChIP-Seq_EPCs_Human1.34222195
44FLI1_27457419_Chip-Seq_LIVER_Mouse1.32029660
45POU3F2_20337985_ChIP-ChIP_501MEL_Human1.31680870
46FLI1_21867929_ChIP-Seq_TH2_Mouse1.30744188
47BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.29423235
48FUS_26573619_Chip-Seq_HEK293_Human1.27431971
49NANOG_20526341_ChIP-Seq_ESCs_Human1.25308746
50PIAS1_25552417_ChIP-Seq_VCAP_Human1.24900285
51EZH2_27294783_Chip-Seq_NPCs_Mouse1.23320784
52TP53_18474530_ChIP-ChIP_U2OS_Human1.22976488
53EP300_21415370_ChIP-Seq_HL-1_Mouse1.22969191
54EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.21241129
55AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.21082425
56FOXH1_21741376_ChIP-Seq_ESCs_Human1.20779961
57CDX2_22108803_ChIP-Seq_LS180_Human1.18415828
58TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.17492634
59TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.17245064
60GATA3_21878914_ChIP-Seq_MCF-7_Human1.16889588
61IGF1R_20145208_ChIP-Seq_DFB_Human1.16697195
62CDX2_19796622_ChIP-Seq_MESCs_Mouse1.16385045
63CTBP1_25329375_ChIP-Seq_LNCAP_Human1.15668495
64MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.12116050
65TP53_22573176_ChIP-Seq_HFKS_Human1.10908153
66KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.10511076
67PRDM14_20953172_ChIP-Seq_ESCs_Human1.10347128
68TDRD3_21172665_ChIP-Seq_MCF-7_Human1.10343590
69SCL_19346495_ChIP-Seq_HPC-7_Human1.09165891
70CEBPB_22108803_ChIP-Seq_LS180_Human1.09053535
71TCF4_22108803_ChIP-Seq_LS180_Human1.09006507
72SMAD4_21799915_ChIP-Seq_A2780_Human1.08921980
73MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.08621790
74VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.08250534
75AR_25329375_ChIP-Seq_VCAP_Human1.07860209
76SOX2_21211035_ChIP-Seq_LN229_Gbm1.07697829
77CRX_20693478_ChIP-Seq_RETINA_Mouse1.07309687
78ER_23166858_ChIP-Seq_MCF-7_Human1.07234798
79ZNF217_24962896_ChIP-Seq_MCF-7_Human1.07010315
80UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.04141146
81MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.00677956
82KDM2B_26808549_Chip-Seq_REH_Human1.00632418
83PKCTHETA_26484144_Chip-Seq_BREAST_Human1.00151936
84CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.99482533
85TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98770735
86NOTCH1_21737748_ChIP-Seq_TLL_Human0.97473510
87LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95443192
88ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.95059963
89TP53_16413492_ChIP-PET_HCT116_Human0.93243725
90TOP2B_26459242_ChIP-Seq_MCF-7_Human0.93064718
91SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.92976327
92GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.92894861
93OCT4_21477851_ChIP-Seq_ESCs_Mouse0.92095041
94SMAD3_21741376_ChIP-Seq_HESCs_Human0.91106738
95SMAD4_21741376_ChIP-Seq_EPCs_Human0.91099082
96TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.91064841
97SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.90619453
98SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.90593703
99CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.90411178
100GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90344322

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009780_abnormal_chondrocyte_physiolo6.72075749
2MP0009278_abnormal_bone_marrow6.65103054
3MP0002876_abnormal_thyroid_physiology4.99505716
4MP0001968_abnormal_touch/_nociception4.20021421
5MP0005360_urolithiasis4.12881191
6MP0005503_abnormal_tendon_morphology3.42777110
7MP0003941_abnormal_skin_development2.79234449
8MP0000678_abnormal_parathyroid_gland2.78995534
9MP0001501_abnormal_sleep_pattern2.66023560
10MP0003880_abnormal_central_pattern2.59485411
11MP0005551_abnormal_eye_electrophysiolog2.53742990
12MP0000681_abnormal_thyroid_gland2.47915528
13MP0001545_abnormal_hematopoietic_system2.42178496
14MP0005397_hematopoietic_system_phenotyp2.42178496
15MP0005646_abnormal_pituitary_gland2.28134931
16MP0009764_decreased_sensitivity_to2.26591353
17MP0003045_fibrosis2.15163040
18MP0001664_abnormal_digestion2.05899792
19MP0003879_abnormal_hair_cell1.94955104
20MP0006035_abnormal_mitochondrial_morpho1.93339041
21MP0003136_yellow_coat_color1.89992860
22MP0000013_abnormal_adipose_tissue1.87099568
23MP0003195_calcinosis1.79992397
24MP0002249_abnormal_larynx_morphology1.74077869
25MP0009333_abnormal_splenocyte_physiolog1.72050782
26MP0003638_abnormal_response/metabolism_1.71765356
27MP0002733_abnormal_thermal_nociception1.71635344
28MP0003959_abnormal_lean_body1.70696106
29MP0003646_muscle_fatigue1.70068970
30MP0008057_abnormal_DNA_replication1.67838432
31MP0003183_abnormal_peptide_metabolism1.66914067
32MP0003633_abnormal_nervous_system1.55716219
33MP0010234_abnormal_vibrissa_follicle1.51751184
34MP0003191_abnormal_cellular_cholesterol1.49604434
35MP0009745_abnormal_behavioral_response1.27011218
36MP0003567_abnormal_fetal_cardiomyocyte1.24734845
37MP0009046_muscle_twitch1.20426775
38MP0003950_abnormal_plasma_membrane1.14903939
39MP0002272_abnormal_nervous_system1.13959557
40MP0001881_abnormal_mammary_gland1.13642297
41MP0000003_abnormal_adipose_tissue1.13296345
42MP0005645_abnormal_hypothalamus_physiol1.11931910
43MP0005670_abnormal_white_adipose1.10596143
44MP0002971_abnormal_brown_adipose1.06324315
45MP0001270_distended_abdomen1.03290672
46MP0002796_impaired_skin_barrier1.00972400
47MP0005334_abnormal_fat_pad1.00283440
48MP0008004_abnormal_stomach_pH0.99872027
49MP0002168_other_aberrant_phenotype0.98676359
50MP0000230_abnormal_systemic_arterial0.98318404
51MP0002638_abnormal_pupillary_reflex0.97954915
52MP0001485_abnormal_pinna_reflex0.95910333
53MP0001486_abnormal_startle_reflex0.95111549
54MP0001970_abnormal_pain_threshold0.93463091
55MP0009765_abnormal_xenobiotic_induced0.91712215
56MP0004858_abnormal_nervous_system0.90797168
57MP0004742_abnormal_vestibular_system0.88745604
58MP0003631_nervous_system_phenotype0.87724604
59MP0008775_abnormal_heart_ventricle0.86123063
60MP0003937_abnormal_limbs/digits/tail_de0.84484312
61MP0004130_abnormal_muscle_cell0.83544166
62MP0004264_abnormal_extraembryonic_tissu0.77870312
63MP0000372_irregular_coat_pigmentation0.76696674
64MP0005195_abnormal_posterior_eye0.74375150
65MP0004782_abnormal_surfactant_physiolog0.73469175
66MP0008874_decreased_physiological_sensi0.73359337
67MP0000538_abnormal_urinary_bladder0.72371271
68MP0000049_abnormal_middle_ear0.72045690
69MP0000749_muscle_degeneration0.71634608
70MP0008872_abnormal_physiological_respon0.70503357
71MP0002693_abnormal_pancreas_physiology0.69324300
72MP0009672_abnormal_birth_weight0.68207404
73MP0005310_abnormal_salivary_gland0.67085110
74MP0002229_neurodegeneration0.65624863
75MP0003868_abnormal_feces_composition0.65033910
76MP0001324_abnormal_eye_pigmentation0.64801039
77MP0002928_abnormal_bile_duct0.62655956
78MP0001963_abnormal_hearing_physiology0.61820531
79MP0002557_abnormal_social/conspecific_i0.59959244
80MP0005452_abnormal_adipose_tissue0.59940781
81MP0010771_integument_phenotype0.59645924
82MP0006072_abnormal_retinal_apoptosis0.59461341
83MP0002735_abnormal_chemical_nociception0.58391324
84MP0003635_abnormal_synaptic_transmissio0.57237373
85MP0000015_abnormal_ear_pigmentation0.56889198
86MP0002148_abnormal_hypersensitivity_rea0.56214430
87MP0002132_abnormal_respiratory_system0.54716842
88MP0004147_increased_porphyrin_level0.54147664
89MP0008058_abnormal_DNA_repair0.53153429
90MP0006276_abnormal_autonomic_nervous0.51874276
91MP0002067_abnormal_sensory_capabilities0.51806056
92MP0003936_abnormal_reproductive_system0.51641601
93MP0005395_other_phenotype0.51132508
94MP0000627_abnormal_mammary_gland0.51090593
95MP0002736_abnormal_nociception_after0.50148139
96MP0002108_abnormal_muscle_morphology0.48997257
97MP0005167_abnormal_blood-brain_barrier0.48097580
98MP0002063_abnormal_learning/memory/cond0.47731941
99MP0000516_abnormal_urinary_system0.47479809
100MP0005367_renal/urinary_system_phenotyp0.47479809

Predicted human phenotypes

RankGene SetZ-score
1Volvulus (HP:0002580)7.27027603
2Intestinal atresia (HP:0011100)6.48738792
3Pancreatic islet-cell hyperplasia (HP:0004510)6.09192225
4Abnormality of the aortic arch (HP:0012303)5.62902135
5Broad alveolar ridges (HP:0000187)5.38028867
6Oligodontia (HP:0000677)5.12167298
7Large for gestational age (HP:0001520)5.09347543
8Thickened helices (HP:0000391)4.66368122
9Poor head control (HP:0002421)4.63839813
10Focal motor seizures (HP:0011153)4.30443263
11Agitation (HP:0000713)4.26580216
12Gaze-evoked nystagmus (HP:0000640)4.23479032
13Mesangial abnormality (HP:0001966)4.16793308
14Congenital ichthyosiform erythroderma (HP:0007431)3.91398796
15Abnormality of endocrine pancreas physiology (HP:0012093)3.83573307
16Abnormality of the pancreatic islet cells (HP:0006476)3.83573307
17Abnormality of the ileum (HP:0001549)3.38903758
18Tubular atrophy (HP:0000092)3.33999108
19Large eyes (HP:0001090)3.23868429
20Gastrointestinal atresia (HP:0002589)3.23321431
21Neonatal respiratory distress (HP:0002643)3.17355175
22Tented upper lip vermilion (HP:0010804)3.15845056
23Chromosomal breakage induced by crosslinking agents (HP:0003221)3.12338440
24Hypoproteinemia (HP:0003075)3.07457073
25Optic nerve hypoplasia (HP:0000609)3.06160963
26Myositis (HP:0100614)2.91616037
27Chromsome breakage (HP:0040012)2.86945073
28Abnormality of macular pigmentation (HP:0008002)2.85943746
29Cerebellar dysplasia (HP:0007033)2.85146851
30Type II lissencephaly (HP:0007260)2.85078077
31Abnormal hair laboratory examination (HP:0003328)2.83694353
32Focal seizures (HP:0007359)2.83375000
33Congenital stationary night blindness (HP:0007642)2.81749941
34Hyperpituitarism (HP:0010514)2.81721877
35Orchitis (HP:0100796)2.73110300
36Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.69929096
37Poor speech (HP:0002465)2.66065627
38Abnormality of the alveolar ridges (HP:0006477)2.62280479
39Nephroblastoma (Wilms tumor) (HP:0002667)2.61500869
40Hyperthyroidism (HP:0000836)2.61099609
41Progressive inability to walk (HP:0002505)2.48455770
42Embryonal renal neoplasm (HP:0011794)2.46006246
43Severe visual impairment (HP:0001141)2.45558413
44Nonprogressive disorder (HP:0003680)2.36934742
45Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.34447373
46Broad-based gait (HP:0002136)2.34204505
47Aplasia/Hypoplasia of the fovea (HP:0008060)2.33598679
48Hypoplasia of the fovea (HP:0007750)2.33598679
49Attenuation of retinal blood vessels (HP:0007843)2.33277650
50Goiter (HP:0000853)2.32716240
51Increased corneal curvature (HP:0100692)2.32318903
52Keratoconus (HP:0000563)2.32318903
53Aplasia/Hypoplasia of the brainstem (HP:0007362)2.31732106
54Hypoplasia of the brainstem (HP:0002365)2.31732106
55Ectropion (HP:0000656)2.30142092
56Abnormal rod and cone electroretinograms (HP:0008323)2.28673388
57Dysdiadochokinesis (HP:0002075)2.27453247
58Dialeptic seizures (HP:0011146)2.27258878
59Elevated erythrocyte sedimentation rate (HP:0003565)2.20350351
60Generalized tonic-clonic seizures (HP:0002069)2.19718058
61Long nose (HP:0003189)2.17084274
62Lissencephaly (HP:0001339)2.16869212
63Restlessness (HP:0000711)2.16740734
64Amelogenesis imperfecta (HP:0000705)2.16483438
65Pili torti (HP:0003777)2.16285017
66Impulsivity (HP:0100710)2.10544842
67Hypercortisolism (HP:0001578)2.04891516
68Thyroid-stimulating hormone excess (HP:0002925)13.8633761
69Hydroxyprolinuria (HP:0003080)1.99902530
70Abnormality of proline metabolism (HP:0010907)1.99902530
71Pendular nystagmus (HP:0012043)1.98766813
72Bony spicule pigmentary retinopathy (HP:0007737)1.94631823
73Cutaneous melanoma (HP:0012056)1.92217121
74Abnormality of the vitreous humor (HP:0004327)1.91616707
75Hypoplasia of the pons (HP:0012110)1.88306160
76Decreased electroretinogram (ERG) amplitude (HP:0000654)1.88110554
77Generalized hypopigmentation of hair (HP:0011358)1.87527407
78Central scotoma (HP:0000603)1.87275851
79Poikiloderma (HP:0001029)1.85035657
80Hamartoma (HP:0010566)1.84747472
81Striae distensae (HP:0001065)1.81395177
82Hypohidrosis (HP:0000966)1.78864560
83Pigmentary retinal degeneration (HP:0001146)1.78777320
84Keratitis (HP:0000491)1.78376571
85Abnormality of the renal cortex (HP:0011035)1.76426897
86Abnormality of the fovea (HP:0000493)1.74399287
87Status epilepticus (HP:0002133)1.74370766
88Muscular dystrophy (HP:0003560)1.73057010
89Entropion (HP:0000621)1.71098583
90Abnormality of the pons (HP:0007361)1.70162957
91Epileptic encephalopathy (HP:0200134)1.68392622
92Adrenal overactivity (HP:0002717)1.66982897
93Cone-rod dystrophy (HP:0000548)1.65977978
94Inability to walk (HP:0002540)1.64203983
95Ileus (HP:0002595)1.62243777
96Abnormality of nail color (HP:0100643)1.62070986
97Scotoma (HP:0000575)1.61803432
98Aplasia/Hypoplasia of the spleen (HP:0010451)1.60746249
99True hermaphroditism (HP:0010459)1.60682583
100Aplasia/Hypoplasia of the abdominal wall musculature (HP:0010318)1.58274391

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.15786654
2ERN14.22256512
3PINK13.49637135
4IRAK32.85329751
5ADRBK12.74718864
6PNCK2.69537979
7ZAK2.25974756
8ADRBK210.4222630
9TLK11.94209921
10CASK1.91838796
11PRKCG1.77991734
12IRAK11.71983142
13ACVR1B1.53804675
14PRKCE1.47628611
15MST41.46207604
16TYRO31.40046377
17DYRK31.34933960
18GRK11.31561432
19TGFBR11.27509911
20BMPR1B1.20681593
21STK38L1.19662634
22PRKCI1.16060152
23MAPK111.11029655
24CLK11.09376473
25CAMK1G1.07321073
26TNIK1.06850031
27PLK21.05690861
28WEE11.03192531
29FLT30.81149579
30MKNK20.80846592
31RIPK10.76035640
32CAMK2A0.75144046
33ERBB20.68105157
34MKNK10.68044946
35MAPKAPK50.64284407
36CDK120.63462702
37BRSK10.58943021
38STK30.58057910
39MELK0.54045055
40STK380.52867809
41GRK70.51563708
42STK100.51238050
43GRK50.49875207
44VRK10.49864577
45DAPK20.49002992
46DYRK1A0.47947271
47TAOK30.47900695
48PHKG10.46750122
49PHKG20.46750122
50CAMK10.46712257
51PIK3CA0.44119263
52CDC70.42996774
53PRKCB0.42392141
54OXSR10.42189704
55NEK90.41585096
56STK390.40980960
57SGK10.38694448
58BCKDK0.38070505
59RPS6KA30.35423849
60CSNK1E0.34783605
61PRKCA0.34698100
62TXK0.33894037
63WNK30.33661414
64MAPK10.33148645
65AKT10.31948546
66CSNK1A10.30046395
67WNK40.28552981
68RPS6KA50.28384888
69PDK20.28342224
70AURKB0.26642583
71ABL10.26606528
72GSK3B0.26505710
73CSNK2A20.25606786
74MAPK30.25230922
75MAPK140.24966596
76BRSK20.24209378
77FGFR20.24185551
78PRKAA10.23914563
79PTK2B0.23892953
80EPHA40.21456761
81EPHA20.20356193
82MARK30.19815697
83PRKACG0.19588908
84PRKACA0.19343013
85CSNK1A1L0.18738909
86TEC0.18493766
87KIT0.18409532
88PIK3CG0.16793666
89ATM0.16657160
90PKN10.16397181
91CDK10.15143739
92KDR0.14903192
93CSNK1G30.14399865
94AKT20.14389315
95CSNK2A10.13300816
96IKBKB0.12868759
97MAPK100.12800326
98CCNB10.12643836
99SIK20.11740662
100PRKDC0.11663628

Predicted pathways (KEGG)

RankGene SetZ-score
1Dorso-ventral axis formation_Homo sapiens_hsa043203.95529249
2Olfactory transduction_Homo sapiens_hsa047403.84667409
3Cyanoamino acid metabolism_Homo sapiens_hsa004603.29121932
4Steroid hormone biosynthesis_Homo sapiens_hsa001402.76333033
5Phototransduction_Homo sapiens_hsa047442.75226069
6Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.73008457
7Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.71286841
8Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.65198411
9ABC transporters_Homo sapiens_hsa020102.54246176
10Morphine addiction_Homo sapiens_hsa050322.42222418
11Sphingolipid metabolism_Homo sapiens_hsa006002.34426627
12Tryptophan metabolism_Homo sapiens_hsa003802.31425103
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.21409173
14Fanconi anemia pathway_Homo sapiens_hsa034602.21401465
15Glycerolipid metabolism_Homo sapiens_hsa005612.18253374
16Pentose phosphate pathway_Homo sapiens_hsa000301.95281057
17Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.92663780
18Butanoate metabolism_Homo sapiens_hsa006501.86732287
19Taste transduction_Homo sapiens_hsa047421.71525775
20Base excision repair_Homo sapiens_hsa034101.63360812
21Ovarian steroidogenesis_Homo sapiens_hsa049131.60545043
22Linoleic acid metabolism_Homo sapiens_hsa005911.59223176
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.57046849
24Caffeine metabolism_Homo sapiens_hsa002321.51591683
25Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.48155009
26Complement and coagulation cascades_Homo sapiens_hsa046101.45450522
27Arachidonic acid metabolism_Homo sapiens_hsa005901.43987450
28Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.41797508
29Glycosaminoglycan degradation_Homo sapiens_hsa005311.33566962
30Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.33183574
31Fatty acid degradation_Homo sapiens_hsa000711.27391083
32alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.26326121
33Sulfur relay system_Homo sapiens_hsa041221.25556452
34Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.22972272
35Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.22010265
36Retinol metabolism_Homo sapiens_hsa008301.21777703
37Starch and sucrose metabolism_Homo sapiens_hsa005001.19069767
38Mineral absorption_Homo sapiens_hsa049781.13177796
39Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.09316846
40Histidine metabolism_Homo sapiens_hsa003401.04381685
41Calcium signaling pathway_Homo sapiens_hsa040201.04190265
42Arginine and proline metabolism_Homo sapiens_hsa003301.01857149
43Salivary secretion_Homo sapiens_hsa049701.01138583
44Chemical carcinogenesis_Homo sapiens_hsa052040.95058891
45One carbon pool by folate_Homo sapiens_hsa006700.89627072
46Estrogen signaling pathway_Homo sapiens_hsa049150.88643653
47Glycerophospholipid metabolism_Homo sapiens_hsa005640.83960608
48Nicotine addiction_Homo sapiens_hsa050330.83924184
49Homologous recombination_Homo sapiens_hsa034400.82822882
50Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.81722721
51Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.81660509
52Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.79734741
53Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.77032588
54Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.76832883
55Nitrogen metabolism_Homo sapiens_hsa009100.76103210
56Basal transcription factors_Homo sapiens_hsa030220.75867190
57Circadian entrainment_Homo sapiens_hsa047130.71916554
58Selenocompound metabolism_Homo sapiens_hsa004500.69806314
59beta-Alanine metabolism_Homo sapiens_hsa004100.65755494
60Carbohydrate digestion and absorption_Homo sapiens_hsa049730.65669745
61RNA degradation_Homo sapiens_hsa030180.65414545
62Glutamatergic synapse_Homo sapiens_hsa047240.64932218
63Ether lipid metabolism_Homo sapiens_hsa005650.64425867
64Fatty acid biosynthesis_Homo sapiens_hsa000610.59538278
65Metabolic pathways_Homo sapiens_hsa011000.59295051
66Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.55626527
67Purine metabolism_Homo sapiens_hsa002300.55000026
68Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.54081656
69Glutathione metabolism_Homo sapiens_hsa004800.52272016
70Serotonergic synapse_Homo sapiens_hsa047260.50940090
71Arginine biosynthesis_Homo sapiens_hsa002200.49191611
72Cysteine and methionine metabolism_Homo sapiens_hsa002700.49017497
73MicroRNAs in cancer_Homo sapiens_hsa052060.47046086
74Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.45486089
75Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.44677757
76Thyroid hormone signaling pathway_Homo sapiens_hsa049190.42690675
77Hedgehog signaling pathway_Homo sapiens_hsa043400.42420878
78Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.41009443
79Basal cell carcinoma_Homo sapiens_hsa052170.39751835
80Vascular smooth muscle contraction_Homo sapiens_hsa042700.39039264
81Pentose and glucuronate interconversions_Homo sapiens_hsa000400.38260565
82Pancreatic secretion_Homo sapiens_hsa049720.37464963
83Insulin secretion_Homo sapiens_hsa049110.37179183
84Lysine degradation_Homo sapiens_hsa003100.36835452
85ECM-receptor interaction_Homo sapiens_hsa045120.34676922
86Sphingolipid signaling pathway_Homo sapiens_hsa040710.32803604
87Primary bile acid biosynthesis_Homo sapiens_hsa001200.30596211
88Legionellosis_Homo sapiens_hsa051340.30389437
89Cardiac muscle contraction_Homo sapiens_hsa042600.29941458
90Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.28343898
91Staphylococcus aureus infection_Homo sapiens_hsa051500.27840467
92Long-term depression_Homo sapiens_hsa047300.27801324
93Intestinal immune network for IgA production_Homo sapiens_hsa046720.27256767
94Oxytocin signaling pathway_Homo sapiens_hsa049210.26944448
95cAMP signaling pathway_Homo sapiens_hsa040240.25213557
96Non-homologous end-joining_Homo sapiens_hsa034500.24735329
97mRNA surveillance pathway_Homo sapiens_hsa030150.24357508
98Lysosome_Homo sapiens_hsa041420.20753080
99Phosphatidylinositol signaling system_Homo sapiens_hsa040700.20275860
100Renin secretion_Homo sapiens_hsa049240.20268221

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