ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	chaperone-mediated protein transport (GO:0072321)	7.52061572
2	establishment of protein localization to mitochondrial membrane (GO:0090151)	7.33730355
3	ATP synthesis coupled proton transport (GO:0015986)	7.02307711
4	energy coupled proton transport, down electrochemical gradient (GO:0015985)	7.02307711
5	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	6.95581951
6	GTP biosynthetic process (GO:0006183)	6.59934242
7	UTP biosynthetic process (GO:0006228)	5.88258105
8	ribosomal small subunit assembly (GO:0000028)	5.76080771
9	UTP metabolic process (GO:0046051)	5.35523579
10	ribosomal small subunit biogenesis (GO:0042274)	5.22981694
11	regulation of mitochondrial translation (GO:0070129)	5.22543372
12	protein complex biogenesis (GO:0070271)	5.08966875
13	respiratory electron transport chain (GO:0022904)	4.97167590
14	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.94381294
15	NADH dehydrogenase complex assembly (GO:0010257)	4.94381294
16	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.94381294
17	electron transport chain (GO:0022900)	4.91941341
18	CTP metabolic process (GO:0046036)	4.91224901
19	CTP biosynthetic process (GO:0006241)	4.91224901
20	protein neddylation (GO:0045116)	4.87626484
21	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.86464588
22	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	4.83902375
23	mitochondrial respiratory chain complex assembly (GO:0033108)	4.80464169
24	viral transcription (GO:0019083)	4.77168125
25	purine nucleoside triphosphate biosynthetic process (GO:0009145)	4.74397774
26	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	4.73957868
27	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	4.73957868
28	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	4.54375141
29	translational termination (GO:0006415)	4.53663632
30	pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)	4.48831543
31	DNA replication checkpoint (GO:0000076)	4.43001125
32	maturation of SSU-rRNA (GO:0030490)	4.41675907
33	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	4.38322766
34	ribonucleoside triphosphate biosynthetic process (GO:0009201)	4.34908493
35	ATP biosynthetic process (GO:0006754)	4.28313365
36	protein targeting to ER (GO:0045047)	4.24122890
37	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	4.23929276
38	cotranslational protein targeting to membrane (GO:0006613)	4.22410540
39	guanosine-containing compound biosynthetic process (GO:1901070)	4.19671774
40	pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)	4.17312764
41	translational elongation (GO:0006414)	4.07822045
42	establishment of protein localization to endoplasmic reticulum (GO:0072599)	4.07715937
43	protein localization to endoplasmic reticulum (GO:0070972)	4.00366662
44	nucleoside diphosphate phosphorylation (GO:0006165)	4.00191198
45	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.99180679
46	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.88369788
47	nucleoside triphosphate biosynthetic process (GO:0009142)	3.81830410
48	hydrogen ion transmembrane transport (GO:1902600)	3.80562342
49	behavioral response to nicotine (GO:0035095)	3.78271281
50	chromatin remodeling at centromere (GO:0031055)	3.77167271
51	kinetochore assembly (GO:0051382)	3.69212601
52	protein-cofactor linkage (GO:0018065)	3.59928657
53	pyrimidine ribonucleoside biosynthetic process (GO:0046132)	3.52510037
54	CENP-A containing nucleosome assembly (GO:0034080)	3.46767594
55	protein K6-linked ubiquitination (GO:0085020)	3.44194650
56	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.40979842
57	viral life cycle (GO:0019058)	3.39657254
58	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.34813615
59	translation (GO:0006412)	3.33370690
60	regulation of helicase activity (GO:0051095)	3.32734046
61	pyrimidine nucleotide biosynthetic process (GO:0006221)	3.31748348
62	cellular protein complex disassembly (GO:0043624)	3.30480363
63	pyrimidine ribonucleotide biosynthetic process (GO:0009220)	3.29060694
64	cellular component biogenesis (GO:0044085)	3.28638383
65	proton transport (GO:0015992)	3.28368160
66	kinetochore organization (GO:0051383)	3.25488377
67	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.25300410
68	termination of RNA polymerase III transcription (GO:0006386)	3.25300410
69	hydrogen transport (GO:0006818)	3.24653223
70	water-soluble vitamin biosynthetic process (GO:0042364)	3.23131696
71	respiratory chain complex IV assembly (GO:0008535)	3.20523165
72	translational initiation (GO:0006413)	3.19343539
73	DNA deamination (GO:0045006)	3.15991552
74	cytochrome complex assembly (GO:0017004)	3.14812559
75	pyrimidine nucleoside biosynthetic process (GO:0046134)	3.07600935
76	cell proliferation in forebrain (GO:0021846)	3.02844610
77	pyrimidine ribonucleotide metabolic process (GO:0009218)	2.99450988
78	peptidyl-histidine modification (GO:0018202)	2.96942242
79	mannosylation (GO:0097502)	2.96041632
80	pyrimidine nucleotide catabolic process (GO:0006244)	2.95287089
81	establishment of protein localization to mitochondrion (GO:0072655)	2.94232953
82	protein targeting to mitochondrion (GO:0006626)	2.92262531
83	pyrimidine nucleotide metabolic process (GO:0006220)	2.91828070
84	sequestering of actin monomers (GO:0042989)	2.91698277
85	pyrimidine-containing compound biosynthetic process (GO:0072528)	2.86507399
86	intracellular protein transmembrane import (GO:0044743)	2.86197543
87	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	2.78986542
88	protein complex disassembly (GO:0043241)	2.78515404
89	ribonucleoprotein complex biogenesis (GO:0022613)	2.77548846
90	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.76615504
91	nuclear-transcribed mRNA catabolic process (GO:0000956)	2.75831102
92	intraciliary transport (GO:0042073)	2.73629795
93	protein localization to mitochondrion (GO:0070585)	2.72301576
94	purine ribonucleoside monophosphate biosynthetic process (GO:0009168)	2.71815683
95	purine nucleoside monophosphate biosynthetic process (GO:0009127)	2.71815683
96	macromolecular complex disassembly (GO:0032984)	2.71516424
97	pyrimidine ribonucleoside metabolic process (GO:0046131)	2.69830253
98	purine ribonucleoside biosynthetic process (GO:0046129)	2.68434283
99	purine nucleoside biosynthetic process (GO:0042451)	2.68434283
100	histone exchange (GO:0043486)	2.66819298

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	5.03329439
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.48590499
3	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.91033406
4	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.31000347
5	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.29079626
6	CREB1_15753290_ChIP-ChIP_HEK293T_Human	3.24455369
7	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.23065434
8	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.22388632
9	ETS1_20019798_ChIP-Seq_JURKAT_Human	3.04209122
10	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.94417282
11	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.88034472
12	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.87898327
13	ELK1_19687146_ChIP-ChIP_HELA_Human	2.58179550
14	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.54904658
15	VDR_23849224_ChIP-Seq_CD4+_Human	2.52880687
16	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.50690481
17	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.35336747
18	IRF1_19129219_ChIP-ChIP_H3396_Human	2.26157906
19	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.23222126
20	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	2.19783861
21	FOXP3_21729870_ChIP-Seq_TREG_Human	2.15012759
22	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.12777594
23	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.06867014
24	MYC_18940864_ChIP-ChIP_HL60_Human	2.05277097
25	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.99193996
26	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.97010241
27	GABP_19822575_ChIP-Seq_HepG2_Human	1.95772782
28	ZNF274_21170338_ChIP-Seq_K562_Hela	1.92880641
29	TTF2_22483619_ChIP-Seq_HELA_Human	1.88926197
30	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.88221335
31	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.88060209
32	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.75217356
33	XRN2_22483619_ChIP-Seq_HELA_Human	1.73812960
34	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.72205396
35	EZH2_22144423_ChIP-Seq_EOC_Human	1.71062934
36	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.67873835
37	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.65607318
38	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.61914545
39	EWS_26573619_Chip-Seq_HEK293_Human	1.58592791
40	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.53950085
41	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.48893215
42	VDR_22108803_ChIP-Seq_LS180_Human	1.48253982
43	IGF1R_20145208_ChIP-Seq_DFB_Human	1.42810878
44	TP53_22573176_ChIP-Seq_HFKS_Human	1.41927650
45	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.41833264
46	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.41256731
47	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.39154063
48	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.33650643
49	E2F7_22180533_ChIP-Seq_HELA_Human	1.33563264
50	NANOG_16153702_ChIP-ChIP_HESCs_Human	1.33163069
51	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.31839879
52	SOX2_18555785_ChIP-Seq_MESCs_Mouse	1.30411360
53	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.28680268
54	DCP1A_22483619_ChIP-Seq_HELA_Human	1.28299073
55	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.28128656
56	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.27205797
57	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.26675199
58	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.24900520
59	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.23869875
60	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.23841559
61	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.22588244
62	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	1.10028742
63	CIITA_25753668_ChIP-Seq_RAJI_Human	1.09655029
64	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.09629274
65	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.09313904
66	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.09195811
67	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.08885583
68	MYC_19829295_ChIP-Seq_ESCs_Human	1.08528349
69	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.08143743
70	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.05862787
71	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.05578217
72	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.04499476
73	FUS_26573619_Chip-Seq_HEK293_Human	1.02838083
74	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.02643617
75	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.01705599
76	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.00039910
77	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.99881551
78	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	0.97833695
79	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	0.96737722
80	P300_19829295_ChIP-Seq_ESCs_Human	0.96689982
81	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.95641787
82	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.95641787
83	NANOG_20526341_ChIP-Seq_ESCs_Human	0.93069711
84	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	0.92471341
85	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.92365453
86	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.91818593
87	FLI1_27457419_Chip-Seq_LIVER_Mouse	0.89195534
88	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.88585648
89	NCOR_22424771_ChIP-Seq_293T_Human	0.88213134
90	SOX2_19829295_ChIP-Seq_ESCs_Human	0.87891677
91	NANOG_19829295_ChIP-Seq_ESCs_Human	0.87891677
92	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	0.86496562
93	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.86390350
94	ERG_20887958_ChIP-Seq_HPC-7_Mouse	0.85911351
95	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.83757964
96	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.82932435
97	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.82895412
98	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	0.80325797
99	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.79770010
100	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.79581704

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	7.60121106
2	MP0009379_abnormal_foot_pigmentation	3.77347783
3	MP0002163_abnormal_gland_morphology	2.48360485
4	MP0001293_anophthalmia	2.44217420
5	MP0005084_abnormal_gallbladder_morpholo	2.35405438
6	MP0003878_abnormal_ear_physiology	2.28621442
7	MP0005377_hearing/vestibular/ear_phenot	2.28621442
8	MP0008789_abnormal_olfactory_epithelium	2.19728761
9	MP0003283_abnormal_digestive_organ	2.09364571
10	MP0008058_abnormal_DNA_repair	2.04763520
11	MP0003011_delayed_dark_adaptation	1.98285737
12	MP0006072_abnormal_retinal_apoptosis	1.93779949
13	MP0004142_abnormal_muscle_tone	1.89033731
14	MP0002938_white_spotting	1.88534548
15	MP0005499_abnormal_olfactory_system	1.86408723
16	MP0005394_taste/olfaction_phenotype	1.86408723
17	MP0003121_genomic_imprinting	1.85574603
18	MP0004147_increased_porphyrin_level	1.82859114
19	MP0003693_abnormal_embryo_hatching	1.73302771
20	MP0002638_abnormal_pupillary_reflex	1.71788842
21	MP0002736_abnormal_nociception_after	1.69732585
22	MP0010030_abnormal_orbit_morphology	1.66418197
23	MP0003122_maternal_imprinting	1.64325918
24	MP0008877_abnormal_DNA_methylation	1.62625907
25	MP0000566_synostosis	1.60584548
26	MP0003186_abnormal_redox_activity	1.59000281
27	MP0005379_endocrine/exocrine_gland_phen	1.55726915
28	MP0008775_abnormal_heart_ventricle	1.55297153
29	MP0001485_abnormal_pinna_reflex	1.53289452
30	MP0001905_abnormal_dopamine_level	1.50203664
31	MP0002837_dystrophic_cardiac_calcinosis	1.50131418
32	MP0001984_abnormal_olfaction	1.47929573
33	MP0003938_abnormal_ear_development	1.46424889
34	MP0005551_abnormal_eye_electrophysiolog	1.44389392
35	MP0000631_abnormal_neuroendocrine_gland	1.44047109
36	MP0003787_abnormal_imprinting	1.41125735
37	MP0002102_abnormal_ear_morphology	1.40105477
38	MP0004145_abnormal_muscle_electrophysio	1.38790523
39	MP0004133_heterotaxia	1.38424495
40	MP0002233_abnormal_nose_morphology	1.34953205
41	MP0006276_abnormal_autonomic_nervous	1.33991416
42	MP0002653_abnormal_ependyma_morphology	1.32960092
43	MP0004742_abnormal_vestibular_system	1.32661968
44	MP0005646_abnormal_pituitary_gland	1.31283176
45	MP0000049_abnormal_middle_ear	1.29152778
46	MP0010094_abnormal_chromosome_stability	1.28593571
47	MP0009046_muscle_twitch	1.27726934
48	MP0002277_abnormal_respiratory_mucosa	1.26048689
49	MP0008872_abnormal_physiological_respon	1.21570812
50	MP0003646_muscle_fatigue	1.19900247
51	MP0003937_abnormal_limbs/digits/tail_de	1.18134256
52	MP0001529_abnormal_vocalization	1.17619704
53	MP0002282_abnormal_trachea_morphology	1.15431613
54	MP0004957_abnormal_blastocyst_morpholog	1.11755951
55	MP0001440_abnormal_grooming_behavior	1.10987510
56	MP0003567_abnormal_fetal_cardiomyocyte	1.09119069
57	MP0001486_abnormal_startle_reflex	1.08073646
58	MP0003111_abnormal_nucleus_morphology	1.05972928
59	MP0002160_abnormal_reproductive_system	1.05504865
60	MP0003195_calcinosis	1.03687316
61	MP0003880_abnormal_central_pattern	1.03517910
62	MP0008932_abnormal_embryonic_tissue	1.03333221
63	MP0005645_abnormal_hypothalamus_physiol	1.03142753
64	MP0008007_abnormal_cellular_replicative	1.02174945
65	MP0001542_abnormal_bone_strength	0.99733390
66	MP0005389_reproductive_system_phenotype	0.97900211
67	MP0000372_irregular_coat_pigmentation	0.97518210
68	MP0003806_abnormal_nucleotide_metabolis	0.96189906
69	MP0002272_abnormal_nervous_system	0.95791651
70	MP0002557_abnormal_social/conspecific_i	0.94579285
71	MP0005408_hypopigmentation	0.92489667
72	MP0002928_abnormal_bile_duct	0.90710908
73	MP0006036_abnormal_mitochondrial_physio	0.90692669
74	MP0005195_abnormal_posterior_eye	0.89177101
75	MP0005391_vision/eye_phenotype	0.88273223
76	MP0009053_abnormal_anal_canal	0.87661239
77	MP0004885_abnormal_endolymph	0.87659201
78	MP0002752_abnormal_somatic_nervous	0.87054905
79	MP0001968_abnormal_touch/_nociception	0.86600223
80	MP0003123_paternal_imprinting	0.85399784
81	MP0001756_abnormal_urination	0.85189322
82	MP0009745_abnormal_behavioral_response	0.83903153
83	MP0005253_abnormal_eye_physiology	0.82957451
84	MP0002697_abnormal_eye_size	0.82889448
85	MP0002184_abnormal_innervation	0.82594922
86	MP0005332_abnormal_amino_acid	0.82385593
87	MP0002249_abnormal_larynx_morphology	0.81599822
88	MP0003077_abnormal_cell_cycle	0.81252916
89	MP0002210_abnormal_sex_determination	0.80893487
90	MP0003786_premature_aging	0.80445521
91	MP0001919_abnormal_reproductive_system	0.80378841
92	MP0001970_abnormal_pain_threshold	0.80277611
93	MP0002733_abnormal_thermal_nociception	0.79479194
94	MP0003136_yellow_coat_color	0.79239357
95	MP0001963_abnormal_hearing_physiology	0.77429094
96	MP0002735_abnormal_chemical_nociception	0.76557131
97	MP0000026_abnormal_inner_ear	0.76252218
98	MP0002090_abnormal_vision	0.73135826
99	MP0001270_distended_abdomen	0.71788144
100	MP0000762_abnormal_tongue_morphology	0.70500258

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	4.54321684
2	Decreased activity of mitochondrial respiratory chain (HP:0008972)	4.37550933
3	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	4.37550933
4	Acute encephalopathy (HP:0006846)	4.17078569
5	Reticulocytopenia (HP:0001896)	4.14433334
6	Abnormal mitochondria in muscle tissue (HP:0008316)	4.05290159
7	Absent rod-and cone-mediated responses on ERG (HP:0007688)	4.04617509
8	Increased hepatocellular lipid droplets (HP:0006565)	3.92246986
9	Mitochondrial inheritance (HP:0001427)	3.85465870
10	3-Methylglutaconic aciduria (HP:0003535)	3.79739585
11	Progressive macrocephaly (HP:0004481)	3.76842314
12	Renal Fanconi syndrome (HP:0001994)	3.72889476
13	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.58433287
14	Absent/shortened dynein arms (HP:0200106)	3.58433287
15	Increased CSF lactate (HP:0002490)	3.57234451
16	Lipid accumulation in hepatocytes (HP:0006561)	3.56903875
17	Septo-optic dysplasia (HP:0100842)	3.55885838
18	Hyperglycinemia (HP:0002154)	3.38714681
19	Abnormality of cells of the erythroid lineage (HP:0012130)	3.29944735
20	Abnormality of midbrain morphology (HP:0002418)	3.18284763
21	Molar tooth sign on MRI (HP:0002419)	3.18284763
22	Abnormal number of erythroid precursors (HP:0012131)	3.08421078
23	Increased intramyocellular lipid droplets (HP:0012240)	3.07326204
24	Cerebral edema (HP:0002181)	2.97901953
25	Abnormal rod and cone electroretinograms (HP:0008323)	2.91194431
26	Pancreatic cysts (HP:0001737)	2.83512296
27	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.75142417
28	Lactic acidosis (HP:0003128)	2.71652392
29	Macrocytic anemia (HP:0001972)	2.66821132
30	Abnormal ciliary motility (HP:0012262)	2.62844840
31	Partial duplication of thumb phalanx (HP:0009944)	2.58396970
32	Hepatocellular necrosis (HP:0001404)	2.56537428
33	Sclerocornea (HP:0000647)	2.55732272
34	Exertional dyspnea (HP:0002875)	2.55008914
35	Methylmalonic aciduria (HP:0012120)	2.54359754
36	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.52315031
37	Abnormality of the labia minora (HP:0012880)	2.50020475
38	Increased serum lactate (HP:0002151)	2.46397626
39	Increased muscle lipid content (HP:0009058)	2.46036462
40	Abnormal respiratory motile cilium morphology (HP:0005938)	2.44896253
41	Abnormal respiratory epithelium morphology (HP:0012253)	2.44896253
42	Nephronophthisis (HP:0000090)	2.44107173
43	Abnormality of renal resorption (HP:0011038)	2.41017891
44	Rib fusion (HP:0000902)	2.40300227
45	True hermaphroditism (HP:0010459)	2.38982415
46	Respiratory failure (HP:0002878)	2.35663838
47	Absent septum pellucidum (HP:0001331)	2.34288842
48	Hepatic necrosis (HP:0002605)	2.32465848
49	Pancreatic fibrosis (HP:0100732)	2.31208300
50	Partial duplication of the phalanx of hand (HP:0009999)	2.30396927
51	Absent thumb (HP:0009777)	2.29483162
52	Limb hypertonia (HP:0002509)	2.29015472
53	Optic disc pallor (HP:0000543)	2.25125755
54	Colon cancer (HP:0003003)	2.24355115
55	Lethargy (HP:0001254)	2.21905415
56	Abnormal respiratory motile cilium physiology (HP:0012261)	2.21195570
57	Adrenal hypoplasia (HP:0000835)	2.19044278
58	Occipital encephalocele (HP:0002085)	2.15026575
59	Exercise intolerance (HP:0003546)	2.14833092
60	Pancreatic islet-cell hyperplasia (HP:0004510)	2.13266029
61	Pancytopenia (HP:0001876)	2.09589035
62	Triphalangeal thumb (HP:0001199)	2.08452293
63	Optic nerve hypoplasia (HP:0000609)	2.04846604
64	Aplastic anemia (HP:0001915)	2.03872136
65	Postaxial foot polydactyly (HP:0001830)	2.03628155
66	Methylmalonic acidemia (HP:0002912)	2.02887260
67	Constricted visual fields (HP:0001133)	2.01642018
68	Abnormality of the metopic suture (HP:0005556)	1.99025020
69	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.98477940
70	Anophthalmia (HP:0000528)	1.98113891
71	Abnormality of the ileum (HP:0001549)	1.96691314
72	Meckel diverticulum (HP:0002245)	1.96575534
73	Oligodactyly (HP:0012165)	1.96502712
74	Maternal diabetes (HP:0009800)	1.95300207
75	Type II lissencephaly (HP:0007260)	1.94542750
76	Degeneration of anterior horn cells (HP:0002398)	1.93289683
77	Abnormality of the anterior horn cell (HP:0006802)	1.93289683
78	Anencephaly (HP:0002323)	1.92363167
79	Birth length less than 3rd percentile (HP:0003561)	1.92042074
80	Abnormality of the renal medulla (HP:0100957)	1.90860800
81	Aplasia/Hypoplasia of the sacrum (HP:0008517)	1.87615702
82	Opisthotonus (HP:0002179)	1.86338180
83	Leukodystrophy (HP:0002415)	1.86067198
84	Hypoplasia of the radius (HP:0002984)	1.83732348
85	Male pseudohermaphroditism (HP:0000037)	1.83007687
86	Abnormality of the septum pellucidum (HP:0007375)	1.82345260
87	Microretrognathia (HP:0000308)	1.81906960
88	Respiratory difficulties (HP:0002880)	1.81216868
89	Congenital, generalized hypertrichosis (HP:0004540)	1.81057034
90	Hyperglycinuria (HP:0003108)	1.78866641
91	Abnormality of macular pigmentation (HP:0008002)	1.78761398
92	Ectopic kidney (HP:0000086)	1.78648879
93	Median cleft lip (HP:0000161)	1.74835253
94	Pallor (HP:0000980)	1.74433927
95	Bifid tongue (HP:0010297)	1.72567108
96	Pendular nystagmus (HP:0012043)	1.71907866
97	Hyperphosphaturia (HP:0003109)	1.70584520
98	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.70307722
99	Holoprosencephaly (HP:0001360)	1.69433198
100	Growth hormone deficiency (HP:0000824)	1.68770106

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	CDC7	4.24386446
2	VRK2	3.83049757
3	ZAK	3.15957034
4	TIE1	2.88824004
5	EPHA4	2.84138895
6	STK16	2.83695529
7	BCKDK	2.68154360
8	NUAK1	2.61598547
9	NME2	2.47184250
10	VRK1	2.33059161
11	TLK1	2.20683400
12	PLK4	2.16227281
13	FRK	2.04690282
14	WNK3	1.95632061
15	MAP4K2	1.88422006
16	KDR	1.76734089
17	BMPR1B	1.72304736
18	GRK1	1.71091956
19	MAP3K9	1.70896764
20	DYRK2	1.68442484
21	NEK1	1.68331573
22	BUB1	1.62920529
23	DMPK	1.46546906
24	TAF1	1.41052882
25	MAP2K7	1.37978359
26	PIK3CA	1.33483989
27	TNIK	1.33444163
28	AURKA	1.32778114
29	MAP3K13	1.32738424
30	TESK2	1.30013747
31	PLK3	1.26664278
32	ADRBK2	1.24644043
33	WNK4	1.20848566
34	SRPK1	1.17762378
35	ARAF	1.16671243
36	DYRK3	1.10992124
37	LIMK1	1.06550624
38	PLK1	1.01877764
39	PLK2	0.98801259
40	RPS6KA5	0.98154743
41	SCYL2	0.94343247
42	MAP2K2	0.94129528
43	AURKB	0.93610785
44	TXK	0.86831975
45	PBK	0.84260023
46	DAPK3	0.83676221
47	CHEK2	0.83495256
48	MAP3K11	0.80738762
49	PINK1	0.77617248
50	CSNK1G3	0.74151685
51	PDK2	0.71570122
52	PRKD3	0.69612070
53	BRAF	0.68801001
54	CSNK1G1	0.66979426
55	PRKCQ	0.66533238
56	TEC	0.64214000
57	ABL2	0.64198913
58	CSNK1G2	0.63928528
59	MOS	0.63193249
60	CAMK1	0.62363631
61	ILK	0.62044643
62	CSNK2A1	0.61705297
63	INSRR	0.60493114
64	PRKCG	0.60408131
65	CSNK2A2	0.60100600
66	MAPK13	0.58292653
67	NEK2	0.57873788
68	ATR	0.57414272
69	NLK	0.56884366
70	PHKG2	0.54506602
71	PHKG1	0.54506602
72	MAPKAPK5	0.53560668
73	CDK19	0.53046412
74	GRK5	0.49705267
75	PRKCE	0.49678875
76	EIF2AK1	0.48586561
77	ATM	0.47916808
78	ACVR1B	0.46852368
79	NTRK1	0.46140998
80	CSNK1E	0.43602957
81	STK39	0.43539555
82	TTK	0.43262337
83	PIK3CG	0.42316064
84	PAK1	0.40699004
85	CSNK1A1L	0.40373499
86	CHEK1	0.39400987
87	NME1	0.38848388
88	PRKACA	0.38136987
89	RPS6KA4	0.36013828
90	ADRBK1	0.35719637
91	MKNK2	0.34792390
92	IKBKB	0.34578545
93	MATK	0.33053227
94	WEE1	0.32956978
95	CSNK1A1	0.31669352
96	OBSCN	0.31398747
97	GRK7	0.31034211
98	OXSR1	0.31025655
99	PRKACB	0.30254429
100	MYLK	0.30116259

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	4.54256855
2	Ribosome_Homo sapiens_hsa03010	4.36266427
3	Parkinsons disease_Homo sapiens_hsa05012	3.77107253
4	RNA polymerase_Homo sapiens_hsa03020	2.95630202
5	Proteasome_Homo sapiens_hsa03050	2.93132115
6	Huntingtons disease_Homo sapiens_hsa05016	2.83058846
7	Protein export_Homo sapiens_hsa03060	2.73735642
8	Homologous recombination_Homo sapiens_hsa03440	2.69049145
9	Alzheimers disease_Homo sapiens_hsa05010	2.63684045
10	DNA replication_Homo sapiens_hsa03030	2.35596547
11	Cardiac muscle contraction_Homo sapiens_hsa04260	2.23619125
12	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.16842099
13	Fanconi anemia pathway_Homo sapiens_hsa03460	2.15443006
14	Pyrimidine metabolism_Homo sapiens_hsa00240	1.99778479
15	Mismatch repair_Homo sapiens_hsa03430	1.89717357
16	Folate biosynthesis_Homo sapiens_hsa00790	1.89134906
17	Sulfur relay system_Homo sapiens_hsa04122	1.85055476
18	Spliceosome_Homo sapiens_hsa03040	1.79937243
19	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.71620198
20	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.70530498
21	Propanoate metabolism_Homo sapiens_hsa00640	1.64828355
22	Asthma_Homo sapiens_hsa05310	1.63308209
23	RNA degradation_Homo sapiens_hsa03018	1.58386017
24	Nucleotide excision repair_Homo sapiens_hsa03420	1.58092513
25	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.57038124
26	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.56813995
27	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.46924143
28	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.38005675
29	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.30483720
30	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.20109793
31	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.18960815
32	Allograft rejection_Homo sapiens_hsa05330	1.15119218
33	Base excision repair_Homo sapiens_hsa03410	1.13089667
34	Butanoate metabolism_Homo sapiens_hsa00650	1.11440107
35	Type I diabetes mellitus_Homo sapiens_hsa04940	1.10513659
36	Purine metabolism_Homo sapiens_hsa00230	1.09885112
37	Basal transcription factors_Homo sapiens_hsa03022	1.08328042
38	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.07583059
39	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.07389855
40	Graft-versus-host disease_Homo sapiens_hsa05332	1.01438879
41	Glutathione metabolism_Homo sapiens_hsa00480	0.95919038
42	Tryptophan metabolism_Homo sapiens_hsa00380	0.95463824
43	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.93797123
44	One carbon pool by folate_Homo sapiens_hsa00670	0.92505629
45	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.91838719
46	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.90940398
47	Phototransduction_Homo sapiens_hsa04744	0.90886820
48	Rheumatoid arthritis_Homo sapiens_hsa05323	0.88892834
49	Collecting duct acid secretion_Homo sapiens_hsa04966	0.87301815
50	Pyruvate metabolism_Homo sapiens_hsa00620	0.86794803
51	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.84227648
52	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.83883286
53	Metabolic pathways_Homo sapiens_hsa01100	0.81768095
54	Sulfur metabolism_Homo sapiens_hsa00920	0.77817206
55	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.76728921
56	Linoleic acid metabolism_Homo sapiens_hsa00591	0.74094999
57	Fatty acid elongation_Homo sapiens_hsa00062	0.72168490
58	Peroxisome_Homo sapiens_hsa04146	0.69585653
59	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.65681352
60	RNA transport_Homo sapiens_hsa03013	0.64425385
61	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.64228753
62	Arginine and proline metabolism_Homo sapiens_hsa00330	0.61717483
63	beta-Alanine metabolism_Homo sapiens_hsa00410	0.61334196
64	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.58986690
65	Steroid biosynthesis_Homo sapiens_hsa00100	0.58899883
66	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.56926274
67	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.56179191
68	Alcoholism_Homo sapiens_hsa05034	0.54827777
69	Olfactory transduction_Homo sapiens_hsa04740	0.54160635
70	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.53781743
71	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.53084086
72	Antigen processing and presentation_Homo sapiens_hsa04612	0.52624893
73	Fatty acid degradation_Homo sapiens_hsa00071	0.50545843
74	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.49398781
75	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.45731100
76	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.42278218
77	Chemical carcinogenesis_Homo sapiens_hsa05204	0.42275266
78	Fat digestion and absorption_Homo sapiens_hsa04975	0.41611808
79	Selenocompound metabolism_Homo sapiens_hsa00450	0.37436838
80	Retinol metabolism_Homo sapiens_hsa00830	0.36511620
81	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.35405594
82	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.34276800
83	Fatty acid metabolism_Homo sapiens_hsa01212	0.33940371
84	Ether lipid metabolism_Homo sapiens_hsa00565	0.32075709
85	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.30898061
86	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.29546425
87	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.29480882
88	Nicotine addiction_Homo sapiens_hsa05033	0.28792269
89	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.25967597
90	Basal cell carcinoma_Homo sapiens_hsa05217	0.25953600
91	Cell cycle_Homo sapiens_hsa04110	0.24606870
92	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.23343696
93	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.20143516
94	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.19734345
95	Tyrosine metabolism_Homo sapiens_hsa00350	0.18589512
96	Non-homologous end-joining_Homo sapiens_hsa03450	0.17820128
97	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.16929096
98	p53 signaling pathway_Homo sapiens_hsa04115	0.16545018
99	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.16178531
100	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.15989524

LSM3P3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »